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Ischaemic conditioning

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https://www.readbyqxmd.com/read/29790195/a-licence-to-drive-neurological-illness-loss-and-disruption
#1
Melissa Stepney, Susan Kirkpatrick, Louise Locock, Suman Prinjha, Sara Ryan
The sense of freedom and independence that being able to drive generates may be taken for granted by many until it is threatened by illness. Drawing on the 'mobility turn' in social sciences that emphasises the social and emotional significance of the car (Sheller and Urry , ), this article presents secondary analysis of narratives of driving and its significance across four neurological conditions (epilepsy, Parkinson's disease, transient ischaemic attack and motor neurone disease). Taking an interactionist approach we explore how the withdrawal of a driving licence can represent not just a practical and emotional loss of independence, but also loss of enjoyment; of a sense and feeling of 'normal' adulthood and social participation; and of an identity (in some cases gendered) of strength and power...
May 22, 2018: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29786124/evaluation-of-the-relationship-between-flap-tension-and-tissue-perfusion-in-implant-based-breast-reconstruction-using-laser-assisted-indocyanine-green-angiography
#2
Chae-Eun Yang, Soon Won Chung, Dong Won Lee, Dae Hyun Lew, Seung Yong Song
BACKGROUND: For implant-based breast reconstruction, inadequate tissue perfusion may cause devastating complications. Tissue tension by inadequate implant volume may reduce tissue perfusion by stretching and collapsing the capillaries. The SPY system is used to perform intraoperative fluorescence angiography with indocyanine green to assess visually the blood flow and evaluate tissue perfusion. However, there is no report yet about how mastectomy flap perfusion changes with the expander-filling volume...
May 21, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29783922/lethal-phlegmonous-colitis
#3
John D Gilbert, Roger W Byard
A 52-year-old man died soon after admission to hospital with a severe metabolic acidosis and likely sepsis. He had a past history of alcohol abuse with withdrawal seizures. An abdominal computed tomography scan showed thickened bowel loops but no obvious ischaemic changes, and a blood culture yielded a pure growth of Escherichia coli. At autopsy, the liver showed well-established micro-nodular cirrhosis with steatosis. The peritoneal cavity contained 200 mL of turbid yellow-brown fluid, and the caecum and ascending colon were unusually thickened...
January 1, 2018: Medicine, Science, and the Law
https://www.readbyqxmd.com/read/29766336/ischaemic-preconditioning-protects-cardiomyocytes-from-anthracycline-induced-toxicity-via-the-pi3k-pathway
#4
Angshuman Maulik, Sean M Davidson, Izabela Piotrowska, Malcolm Walker, Derek M Yellon
PURPOSE: Anthracyclines cause chronic irreversible cardiac failure, but the mechanism remains poorly understood. Emerging data indicate that cardiac damage begins early, suggesting protective modalities delivered in the acute stage may confer prolonged benefit. Ischaemic preconditioning (IPC) activates the pro-survival reperfusion injury salvage kinase (RISK) pathway which involves PI3-kinase and MAPK/ERK1/2. METHODS: We investigated whether simulated IPC (sIPC), in the form of a sublethal exposure to a hypoxic buffer simulating ischaemic conditions followed by reoxygenation, protects primary adult rat cardiomyocytes against anthracycline-induced injury...
May 15, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29748743/erythropoietin-and-nrf2-key-factors-in-the-neuroprotection-provided-by-apo-lactoferrin
#5
E T Zakharova, A V Sokolov, N N Pavlichenko, V A Kostevich, I N Abdurasulova, A V Chechushkov, I V Voynova, A Yu Elizarova, N N Kolmakov, M G Bass, I V Semak, A I Budevich, P M Kozhin, N K Zenkov, V M Klimenko, O V Kirik, D E Korzhevskii, E B Menshchikova, V B Vasilyev
Among the properties of lactoferrin (LF) are bactericidal, antianemic, immunomodulatory, antitumour, antiphlogistic effects. Previously we demonstrated its capacity to stabilize in vivo HIF-1-alpha and HIF-2-alpha, which are redox-sensitive multiaimed transcription factors. Various tissues of animals receiving recombinant human LF (rhLF) responded by expressing the HIF-1-alpha target genes, hence such proteins as erythropoietin (EPO), ceruloplasmin, etc. were synthesized in noticeable amounts. Among organs in which EPO synthesis occurred were brain, heart, spleen, liver, kidneys and lungs...
May 10, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29748420/daily-remote-ischaemic-conditioning-following-acute-myocardial-infarction-a-randomised-controlled-trial
#6
Andrew Peter Vanezis, Jayanth Ranjit Arnold, Glenn Rodrigo, Florence Y Lai, Radek Debiec, Sheraz Nazir, Jamal Nasir Khan, Leong L Ng, Kamal Chitkara, John G Coghlan, Simon Lee Hetherington, Gerry P McCann, Nilesh J Samani
BACKGROUND: Remote ischaemic conditioning (rIC) is a cardioprotective tool which has shown promise in preclinical and clinical trials in the context of acute ischaemia. Repeated rIC post myocardial infarction may provide additional benefits which have not previously been tested clinically. METHODS: The trial assessed the role of daily rIC in enhancing left ventricular ejection fraction (LVEF) recovery in patients with impaired LVEF (<45%) after ST segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (P-PCI)...
May 10, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29746622/socioeconomic-factors-and-mortality-in-patients-with-atrial-fibrillation-a-cohort-study-in-swedish-primary-care
#7
Per Wändell, Axel C Carlsson, Danijela Gasevic, Martin J Holzmann, Johan Ärnlöv, Jan Sundquist, Kristina Sundquist
Background: Preventing ischaemic stroke attracts significant focus in atrial fibrillation (AF) cases. Less is known on the association between socioeconomic factors and mortality and cardiovascular outcomes in patients with AF. Methods: Our study population included adults (n=12 283) ≥45 years diagnosed with AF at 75 primary care centres in Sweden 2001-07. Cox regression was used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs) for the association between the exposures educational level, marital status, neighbourhood socioeconomic status and the outcomes all-cause mortality, after adjustment for age, and comorbid cardiovascular conditions...
May 9, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29745965/stroke-distribution-patterns-and-characteristics-in-kenya-s-leading-public-health-tertiary-institutions-kenyatta-national-hospital-and-moi-teaching-and-referral-hospital
#8
Lydia Kaduka, Anne Korir, Chrispine Owuor Oduor, Judith Kwasa, Jane Mbui, Sylvanos Wabwire, Robai Gakunga, Nathan Okerosi, Yvonne Opanga, Isaac Kisiang'ani, Mercy Rotich Chepkurui, Erastus Muniu, Scot C Remick
BACKGROUND: Cardiovascular diseases are the second leading cause of morbidity and mortality in Kenya. However, there is limited clinic-epidemiological data on stroke to inform decision making. This study sought to establish stroke distribution patterns and characteristics in patients seeking care at Kenyatta National Hospital (KNH) and Moi Teaching and Referral Hospital (MTRH), with the ultimate aim of establishing the first national stroke registry in Kenya. METHODS: This was a prospective multicentre cohort study among stroke patients...
March 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29742058/neurological-manifestations-in-autoinflammatory-diseases
#9
REVIEW
Antonio Uccelli, Marco Gattorno
Autoinflammatory diseases (AIDs) are a distinct group of diseases characterised by a dysregulation of the innate immune response leading to systemic inflammation. The clinical spectrum of these conditions is extremely variable and possibly every system and tissue can be involved, including the central nervous system (CNS). Indeed, neurological manifestations may dominate the clinical picture from disease onset in some rare conditions. However, the involvement of the CNS in AIDs is not a disease in itself, but represents a rare complication which is consequent to a systemic or local immune response, mainly involving cells of the innate immunity...
January 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29734900/the-acutely-blue-finger-cause-for-concern
#10
Marc A Seifman, Bruce R Johnstone
An acutely blue finger may cause concern, with both ischaemic and non-ischaemic aetiologies. Achenbach syndrome is a rare condition involving spontaneous haematoma of the finger. We present a case with distinct histological findings and a family history.
June 2018: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29727304/the-frequency-characteristics-and-aetiology-of-stroke-mimic-presentations-a-narrative-review
#11
Graham McClelland, Helen Rodgers, Darren Flynn, Christopher I Price
A significant proportion of patients with acute stroke symptoms have an alternative 'mimic' diagnosis. A narrative review was carried out to explore the frequency, characteristics and aetiology of stroke mimics. Prehospital and thrombolysis-treated patients were described separately. Overall, 9972 studies were identified from the initial search and 79 studies were included with a median stroke mimic rate of 19% (range: 1-64%). The prehospital median was 27% (range: 4-43%) and the thrombolysis median 10% (range: 1-25%)...
May 1, 2018: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/29722092/administration-of-cripto-in-grp78-overexpressed-human-mscs-enhances-stem-cell-viability-and-angiogenesis-during-human-msc-transplantation-therapy
#12
S Kim, Y M Yoon, Y-S Han, J H Lee, J Hur, S H Lee
OBJECTIVES: The purpose of this study was to explore the effectiveness of concurrent GRP78 overexpression combined with Cripto on hMSC proliferation and migration both in vitro and in vivo. Specifically, we explored whether the treatment enhances effectiveness of hMSC transplantation in ischaemic tissue. MATERIALS AND METHODS: Human MSCs obtained from human adipose tissue were cultured in α-minimum essential medium (Hyclone, Logan, UT, USA) supplemented with 10% (v/v) foetal bovine serum (Hyclone), 100 U mL-1 penicillin and 100 μg mL-1 streptomycin...
May 2, 2018: Cell Proliferation
https://www.readbyqxmd.com/read/29719079/effects-of-ipsilateral-and-contralateral-fatigue-and-muscle-blood-flow-occlusion-on-the-complexity-of-knee-extensor-torque-output-in-humans
#13
Jamie Pethick, Samantha L Winter, Mark Burnley
NEW FINDINGS: In this study we show that the fatigue-induced loss of isometric torque complexity does not recover if the fatigued muscle's blood flow is occluded during recovery, suggesting a pivotal role for peripheral mechanisms in this effect. When the contralateral limb is fatigued, the complexity of isometric torque output is unaffected even if the contralateral limb's blood flow is occluded, which suggests neither central fatigue nor afferent feedback from ischaemic muscle influence the complexity of torque output in an otherwise fresh muscle...
May 2, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29703741/hyperpolarised-magnetic-resonance-for-in-vivo-real-time-metabolic-imaging
#14
REVIEW
Andrew Apps, Justin Lau, Mark Peterzan, Stefan Neubauer, Damian Tyler, Oliver Rider
Although non-invasive perfusion and viability imaging often provide the gateway to coronary revascularisation, current non-invasive imaging methods only report the surrogate markers of inducible hypoperfusion and presence or absence of myocardial scar, rather than actually visualising areas of ischaemia and/or viable myocardium. This may lead to suboptimal revascularisation decisions. Normally respiring (viable) cardiomyocytes convert pyruvate to acetyl-CoA and CO2 /bicarbonate (via pyruvate dehydrogenase), but under ischaemic conditions characteristically shift this conversion to lactate (by lactate dehydrogenase)...
April 27, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29697213/diagnosis-and-management-of-patients-with-atrial-fibrillation
#15
Kay Elliott
Atrial fibrillation is a common cardiac arrhythmia and is the most frequent arrhythmia experienced by older people. It is caused by chaotic electrical activity in the atria, leading to an irregular and often rapid heart rate. Atrial fibrillation is associated with an increased risk of ischaemic stroke, resulting from the turbulent blood flow in the atria. This article details the presentation of, and risk factors associated with, developing atrial fibrillation, the importance of reducing the risk of adverse events such as stroke, and the treatment options available...
April 26, 2018: Nursing Standard
https://www.readbyqxmd.com/read/29695236/associations-between-comorbidities-their-treatment-and-survival-in-patients-with-interstitial-lung-diseases-a-claims-data-analysis
#16
Larissa Schwarzkopf, Sabine Witt, Julia Waelscher, Markus Polke, Michael Kreuter
BACKGROUND: Interstitial lung diseases (ILDs) are associated with a high burden of disease. However, data on the prognostic impact of comorbidities and comorbidity-related pharmaceutical treatments in patients with various ILDs remain sparse. METHODS: Using longitudinal claims data from a German Statutory Health Insurance Fund, we assessed comorbidity in ILD subtypes and associated drug treatments. Baseline comorbidity was assessed via the Elixhauser Comorbidity Index that was amended by ILD-relevant conditions...
April 25, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29682860/the-role-of-chronic-kidney-disease-and-atrial-fibrillation-on-outcomes-of-ischaemic-stroke-patients
#17
Ahsan A Khan, Gregory Y H Lip
Stroke is one of the leading causes of morbidity and mortality in the western world. Approximately 85% of strokes are ischaemic, caused by vascular occlusion either due to acute thrombus or emboli often as a result of atrial fibrillation (AF). Other age dependent conditions such as hypertension and diabetes mellitus lead to impairment of renal function and development of chronic kidney disease (CKD). Indeed, CKD is increasingly prevalent in the elderly population and is an independent predictor of stroke recurrence, mortality and poor clinical outcomes after acute ischaemic stroke (1)...
April 23, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29666676/ranolazine-a-true-pluripotent-cardiovascular-drug-or-jack-of-all-trades-master-of-none
#18
REVIEW
Alice Mezincescu, V J Karthikeyan, Sunil K Nadar
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Although the majority of patients with CVD are treated with interventional procedures, a substantial number require medical therapy in terms of both prognosis and symptomatic relief. However, commonly used agents such as β-blockers and calcium channel blockers reduce blood pressure in patients whose resting pressures are often already low. Ranolazine is a promising agent that does not have significant effects on blood pressure or heart rate...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29666179/increasing-trends-in-hospital-care-burden-of-atrial-fibrillation-in-korea-2006-through-2015
#19
Daehoon Kim, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y H Lip
OBJECTIVE: Temporal changes in the healthcare burden of atrial fibrillation (AF) are less well known in rapidly ageing Asian countries. We examined trends in hospitalisations, costs, treatment patterns and outcomes related to AF in Korea. METHODS: Using the National Health Insurance Service (NHIS) database involving the entire adult Korean population (n=41 701 269 in 2015), we analysed a nationwide AF cohort representing 931 138 patients with AF. We studied all hospitalisations due to AF from 2006 to 2015...
April 17, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29659795/managing-uncertainty-a-qualitative-study-of-gps-views-on-the-diagnosis-and-immediate-management-of-transient-ischaemic-attack-and-the-potential-of-a-diagnostic-tool
#20
Priyanka Bose, Carolyn Tarrant, Amit K Mistri, Andrew Wilson
Background: Most patients with transient ischaemic attack (TIA) present to their GP. Early identification and treatment reduces the risk of subsequent stroke and consequent disability and mortality. Objective: To explore GPs' views on the diagnosis and immediate management of suspected TIA, and the potential utility of a diagnostic tool. Methods: This is a qualitative interview study based in Leicestershire, UK. A purposive sample of 10 GPs participated in 30-minute semi-structured telephone interviews...
April 12, 2018: Family Practice
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