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https://www.readbyqxmd.com/read/29166752/immunotherapy-treatment-an-issue-for-metabolic-response
#1
Luca Tagliabue, Antonella Capozza, Claudio Maioli, Andrea Luciani, Anna M Ierardi, Gianpaolo Carrafiello
Since the beginning of second decade of this century, when it was introduced in many oncologic scenarios, immunotherapy has become an important tool in the management of a growing number of cancers. Engaging the host immune system in cancer therapy seems to be useful, improving not only progression free survival but also overall survival, until the achieving the goal that many advanced cancers, previously considered without effective treatment options, have now become successfully treatable. Moreover, considering the relatively recent introduction of these drugs in clinical scenarios and the continuous releasing of new drugs, large validated clinical experiences are lacking and many issues are today debated; by the way, the evaluation of the response to immune-therapy poses major concerns...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166665/meditation-experts-try-virtual-reality-mindfulness-a-pilot-study-evaluation-of-the-feasibility-and-acceptability-of-virtual-reality-to-facilitate-mindfulness-practice-in-people-attending-a-mindfulness-conference
#2
María V Navarro-Haro, Yolanda López-Del-Hoyo, Daniel Campos, Marsha M Linehan, Hunter G Hoffman, Azucena García-Palacios, Marta Modrego-Alarcón, Luis Borao, Javier García-Campayo
Regular mindfulness practice benefits people both mentally and physically, but many populations who could benefit do not practice mindfulness. Virtual Reality (VR) is a new technology that helps capture participants' attention and gives users the illusion of "being there" in the 3D computer generated environment, facilitating sense of presence. By limiting distractions from the real world, increasing sense of presence and giving people an interesting place to go to practice mindfulness, Virtual Reality may facilitate mindfulness practice...
2017: PloS One
https://www.readbyqxmd.com/read/29166593/neural-correlates-of-improvements-in-personality-and-behavior-following-a-neurological-event
#3
Marcie L King, Kenneth Manzel, Joel Bruss, Daniel Tranel
Research on changes in personality and behavior following brain damage has focused largely on negative outcomes, such as increased irritability, moodiness, and social inappropriateness. However, clinical observations suggest that some patients may actually show positive personality and behavioral changes following a neurological event. In the current work, we investigated neuroanatomical correlates of positive personality and behavioral changes following a discrete neurological event (e.g., stroke, benign tumor resection)...
November 19, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29166504/moderate-to-severe-psoriasis-treatment-challenges-through-the-era-of-biological-drugs
#4
Júlia Vide, Sofia Magina
Biological therapy has revolutionized moderate to severe psoriasis treatment. However, despite being more effective than conventional systemic treatments, some patients do not respond or lose response to biotechnological treatments or develop drug-antibodies, interfering with its safety and efficacy. There are also clinical forms of the disease and patient profiles for which is pending further scientific evidence for more sustained therapeutic interventions. The continuous and more detailed knowledge of psoriasis pathophysiology has allowed identifying new therapeutic targets, which is expected to help overcome the challenges of individualized psoriasis treatment...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166311/the-use-and-delivery-of-stem-cells-in-nerve-regeneration-preclinical-evidence-and-regulatory-considerations
#5
Abdel Armaiz Flores, Huan Wang
Outcomes following peripheral nerve injury remain poor despite the regenerative capacity displayed by the peripheral nervous system. Current therapies are limited and do not provide satisfactory functional recovery in a multitude of cases. Biomaterials have decreased the need for nerve autograft across small nerve gaps in small-caliber nerves, but the lack of a cellular substrate presents a limiting factor to the effectiveness of this therapy. Schwann cells are the supportive cells in the peripheral nervous system and play an integral role in the physiological response and regeneration following nerve injury...
November 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29166260/the-development-and-content-validation-of-a-multidisciplinary-evidence-based-wound-infection-prevention-and-treatment-guideline
#6
Sammy A Zakhary, Chris Davey, Rebecca Bari, Jordan Bean, Tyler Reber, Kathy Gallagher, Kara Couch, Jennifer Hurlow, Karen Laforet, Corrine McIssac, Karen Napier, Diana Vilar-Compte, Emily Zakhary, Michel Hermans, Laura Bolton
Acute and chronic wound infections create clinical, economic, and patient-centered challenges best met by multidisciplinary wound care teams providing consistent, valid, clinically relevant, safe, evidence-based management across settings. To develop an evidence-based wound infection guideline, PubMed, Cochrane Library, and Cumulative Index to Nursing and Allied Health Literature databases were searched from inception through August 1, 2017 using the terms (or synonyms) wound infection and risk factor, significant, diagnosis, prevention, treatment, or surveillance...
November 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/29166205/pregnant-women-with-heart-disease-placental-characteristics-and-their-association-with-fetal-adverse-events
#7
Fabio V Lima, Paraskevi Koutrolou-Sotiropoulou, Puja B Parikh, Cecilia Avila, Javed Butler, Kathleen Stergiopoulos
BACKGROUND: Pregnant women with heart disease (HD) have higher rates of adverse fetal outcomes. We describe placental pathologic characteristics and their association with fetal events. METHODS: In pregnant women, known HD were categorized into: (1) cardiomyopathy (CM) or (2) other HD (congenital, coronary, arrhythmia, or valvular). Outcomes were maternal major adverse cardiac events (MACE), fetal adverse clinical events (FACE), a composite of infant death, prematurity, underweight status, intracranial hemorrhage, and respiratory distress...
November 22, 2017: Acute Cardiac Care
https://www.readbyqxmd.com/read/29165964/preventing-intradialytic-hypotension-translating-evidence-into-practice
#8
Wendi Bradshaw, Paul N Bennett, Cherene Ockerby, Alison M Hutchinson, Peter G Kerr
Intradialytic hypotension (IDH) remains the most frequent severe side effect of hemodialysis. This prospective, exploratory study aimed to measure the compliance of an IDH prevention pathway and to identify the effects of pathway use on hypotension incidence. Additionally, the study explored barriers and facilitators to pathway implementation in five hemodialysis centers. Instituting an ultrafiltration pause decreased the odds of hypotensive episodes by 44% (OR = 0.56, 95% CI = 0.20 to 1.56, χ2 1 = 1.25, p = 0...
March 2017: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/29165963/post-transfer-predictors-of-poor-outcomes-in-pediatric-renal-transplant-recipients
#9
Bethany Coyne, Patricia J Hollen, Guofen Yan, John Barcia, Kenneth Brayman
The aims of this study were twofold: 1) to describe the post-transfer (defined as from pediatric to adult providers) incidence of predictors (medication nonadherence, acute rejection, and change in kidney function), as well as outcomes (graft loss) for adolescent and young adult kidney transplant recipients during a three-year post-transfer follow-up period; and 2) to identify variables to monitor these predictors, in the form of a clinical profile, so providers can promote early intervention for these medically at-risk adolescents...
March 2017: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/29165952/identifying-and-eliminating-the-barriers-to-patient-education-for-patients-in-the-early-stages-of-chronic-kidney-disease
#10
Sherry Rivera
Patients with chronic kidney disease (CKD) often do not have the knowledge they need to adequately manage their disease and prevent progression. Educating patients with the early stages of CKD is warranted and may assist in delaying progression of disease, improving outcomes, and reducing health expenditures. However, evidence is currently lacking regarding the best methods and approach to educating patients in the early stages of CKD. Multiple patient, provider, and system barriers can interfere with the delivery of patient education in the early stages of CKD...
May 2017: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/29165784/interventions-for-managing-skeletal-muscle-spasticity-following-traumatic-brain-injury
#11
REVIEW
Anneliese Synnot, Marisa Chau, Veronica Pitt, Denise O'Connor, Russell L Gruen, Jason Wasiak, Ornella Clavisi, Loyal Pattuwage, Kate Phillips
BACKGROUND: Skeletal muscle spasticity is a major physical complication resulting from traumatic brain injury (TBI), which can lead to muscle contracture, joint stiffness, reduced range of movement, broken skin and pain. Treatments for spasticity include a range of pharmacological and non-pharmacological interventions, often used in combination. Management of spasticity following TBI varies from other clinical populations because of the added complexity of behavioural and cognitive issues associated with TBI...
November 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29165777/the-use-of-crystalloids-in-traumatic-brain-injury
#12
Wojciech Dąbrowski, Tom Woodcock, Ziemowit Rzecki, Manu L N G Malbrain
Fluid therapy is one of the most important treatments in patients with traumatic brain injury (TBI) as both hypo- and hypervolaemia can cause harm. The main goals of fluid therapy for patients with TBI are to optimize cerebral perfusion and to maintain adequate cerebral oxygenation. The avoidance of cerebral oedema is clearly essential. The current weight of evidence in the published literature suggests that albumin therapy is harmful and plasma substitutes have failed to demonstrate superiority over crystalloids solutions...
November 22, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/29165669/clinvar-improving-access-to-variant-interpretations-and-supporting-evidence
#13
Melissa J Landrum, Jennifer M Lee, Mark Benson, Garth R Brown, Chen Chao, Shanmuga Chitipiralla, Baoshan Gu, Jennifer Hart, Douglas Hoffman, Wonhee Jang, Karen Karapetyan, Kenneth Katz, Chunlei Liu, Zenith Maddipatla, Adriana Malheiro, Kurt McDaniel, Michael Ovetsky, George Riley, George Zhou, J Bradley Holmes, Brandi L Kattman, Donna R Maglott
ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/) is a freely available, public archive of human genetic variants and interpretations of their significance to disease, maintained at the National Institutes of Health. Interpretations of the clinical significance of variants are submitted by clinical testing laboratories, research laboratories, expert panels and other groups. ClinVar aggregates data by variant-disease pairs, and by variant (or set of variants). Data aggregated by variant are accessible on the website, in an improved set of variant call format files and as a new comprehensive XML report...
November 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29165627/health-literacy-and-patient-outcomes-in-chronic-kidney-disease-a-systematic-review
#14
Dominic M Taylor, Simon Fraser, Chris Dudley, Gabriel C Oniscu, Charles Tomson, Rommel Ravanan, Paul Roderick
Background: Limited health literacy affects 25% of people with chronic kidney disease (CKD), and may reduce self-management skills resulting in poorer clinical outcomes. By disproportionately affecting people with low socio-economic status and non-white ethnicity, limited health literacy may promote health inequity. Methods: We performed a systematic review of quantitative studies of health literacy and clinical outcomes among adults with CKD. Results: A total of 29 studies (13 articles; 16 conference abstracts) were included...
November 20, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29165596/molecular-relatedness-of-esbl-ampc-producing-escherichia-coli-from-humans-animals-food-and-the-environment-a-pooled-analysis
#15
Alejandro Dorado-García, Joost H Smid, Wilfrid van Pelt, Marc J M Bonten, Ad C Fluit, Gerrita van den Bunt, Jaap A Wagenaar, Joost Hordijk, Cindy M Dierikx, Kees T Veldman, Aline de Koeijer, Wietske Dohmen, Heike Schmitt, Apostolos Liakopoulos, Ewa Pacholewicz, Theo J G M Lam, Annet G Velthuis, Annet Heuvelink, Maaike A Gonggrijp, Engeline van Duijkeren, Angela H A M van Hoek, Ana Maria de Roda Husman, Hetty Blaak, Arie H Havelaar, Dik J Mevius, Dick J J Heederik
Background: In recent years, ESBL/AmpC-producing Escherichia coli (ESBL/AmpC-EC) have been isolated with increasing frequency from animals, food, environmental sources and humans. With incomplete and scattered evidence, the contribution to the human carriage burden from these reservoirs remains unclear. Objectives: To quantify molecular similarities between different reservoirs as a first step towards risk attribution. Methods: Pooled data on ESBL/AmpC-EC isolates were recovered from 35 studies in the Netherlands comprising >27 000 samples, mostly obtained between 2005 and 2015...
November 18, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29165595/con-the-role-of-diet-for-people-with-advanced-stage-5-ckd
#16
Graham Woodrow
Restriction of dietary protein intake has been used in the management of chronic kidney disease (CKD) for many decades, yet remains controversial, with marked variations in its application in clinical practice. There is extensive literature on the subject, with some expert opinion advocating the use of protein restriction based on the balance of the available evidence. The largest randomized trial of low-protein diets is the Modification of Diet in Renal Disease study. Despite multiple secondary analyses, the essential intention-to-treat analysis failed to demonstrate a benefit in the primary outcome of rate of decline of glomerular filtration rate...
November 17, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29165579/investigating-mediators-of-the-poor-pneumonia-outcomes-of-human-immunodeficiency-virus-exposed-but-uninfected-children
#17
Matthew S Kelly, Jiayin Zheng, Sefelani Boiditswe, Andrew P Steenhoff, Kristen A Feemster, Tonya Arscott-Mills, Boitshepe Seme, Bakgaki Ratshaa, Ikanyeng Rulaganyang, Mohamed Z Patel, Savarra Mantzor, Samir S Shah, Coleen K Cunningham
Background: Human immunodeficiency virus-exposed but uninfected (HIV-EU) children have a higher mortality rate than the children of HIV-negative mothers (HIV-unexposed). Causal mediators of the poor health outcomes of HIV-EU children remain poorly defined. Methods: We conducted a hospital-based prospective cohort study of children aged 1 to 23 months with clinically defined pneumonia. The children were recruited at a referral hospital in Gaborone, Botswana, between April 2012 and June 2016...
November 20, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29165416/-a-case-of-progressive-glaucoma-against-the-background-of-chronic-constipation
#18
A E Vasil'eva, N V Makashova, I A Ronzina, O Yu Kolosova, K V Goncharenko
The authors describe a case of severe glaucoma in the only seeing eye of a patient with venous circulation disturbance resulting from a chronic anal fissure complicated with progressive anal stenosis, severe sphincter spasm, and pain syndrome. The article presents the results of multiple clinical ophthalmological tests and instrumental examinations performed before and after surgical intervention that evidence the importance of venous circulation disturbances for glaucoma development.
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29165401/systematic-overview-of-bacopa-monnieri-l-wettst-dominant-poly-herbal-formulas-in-children-and-adolescents
#19
REVIEW
James D Kean, Luke A Downey, Con Stough
Background: The Ayurvedic medicinal system employs a holistic approach to health, utilising the synergistic properties of organic resources. Research into the Ayurvedic herb Bacopa monnieri (L.) Wettst. (B.monnieri) has reported improvements in cognitive outcomes in child and adult populations. The aim of current review is to systematically assess and critically summarize clinical trials investigating B.monnieri-dominant poly-herbal formulas and their effects on the cognition, memory, learning, and behaviour in children and adolescents...
November 22, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29165371/veterinarian-nominated-common-conditions-of-rabbits-and-guinea-pigs-compared-with-published-literature
#20
Natalie J Robinson, Emma Lyons, Douglas Grindlay, Marnie L Brennan
Rabbits and guinea pigs are increasingly popular pets in the UK, yet little is known about their common ailments, or how these relate to what appears in the published literature. The aim of this study was to characterise the common conditions of rabbits and guinea pigs, and to compare these with the topics found in the published literature. Information about the common conditions seen in rabbits and guinea pigs in clinical practice was obtained from a survey of UK veterinarians. The common conditions seen were compared with results from a structured literature search...
November 22, 2017: Veterinary Sciences
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