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Cognitive dysfunction in cancer patients

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https://www.readbyqxmd.com/read/28080264/convergent-and-criterion-validity-of-the-cogstate-computerized-brief-battery-cognitive-assessment-in-women-with-and-without-breast-cancer
#1
Sunita K Patel, Adrienne M Meier, Nathaniel Fernandez, Tracy T Y Lo, Colleen Moore, Nicole Delgado
OBJECTIVE: Computerized tests have increasingly garnered interest for assessing cognitive functioning due to their potential logistical and financial advantages over traditional 'pencil and-paper' neuropsychological tests. However, psychometric information is necessary to guide decisions about their clinical and research utility with varied populations. We explored the convergent construct validity and criterion validity of the CogState computerized tests in breast cancer survivors, a group known to present with mostly mild, subtle cognitive dysfunction...
January 12, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28060691/sexual-dysfunction-in-breast-cancer-survivors-cross-cultural-adaptation-of-the-sexual-activity-questionnaire-for-use-in-portugal
#2
Filipa Alves da Costa, Manuel Castro Ribeiro, Sofia Braga, Elisabete Carvalho, Fátima Francisco, Ana Costa Miranda, António Moreira, Lesley Fallowfield
INTRODUCTION: The increasing survivor population of breast cancer has shifted research and practice interests into the impacts of the disease and treatment in quality of life aspects. The lack of tools available in Portuguese to objectively evaluate sexual function led to the development of this study, which aimed to cross-culturally adapt and validate the Sexual Activity Questionnaire for use in Portugal. MATERIAL AND METHODS: The questionnaire was translated and back-translated, refined following face-to-face interviews with seven breast cancer survivors, and then self-administered by a larger sample at baseline and a fortnight later to test validity and reliability...
September 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28055110/survivorship-after-lower-gastrointestinal-cancer-patient-reported-outcomes-and-planning-for-care
#3
Melissa A Frick, Carolyn C Vachani, Margaret K Hampshire, Christina Bach, Karen Arnold-Korzeniowski, James M Metz, Christine E Hill-Kayser
BACKGROUND: There is significant need for quality follow-up care to optimize long-term outcomes for the growing population of lower gastrointestinal (GI) cancer survivors. Patient-reported outcomes (PROs) provide valuable information regarding late and long-term effects (LLTEs). METHODS: A convenience sample from 1129 colon, rectal, and anal cancer survivors (n = 792; 218, and 119, respectively) who participated in an Internet-based survivorship care plan (SCP) tool between May 2010 and October 2014 was used to examine patient-reported demographics, treatment, and toxicity data...
January 5, 2017: Cancer
https://www.readbyqxmd.com/read/28039595/the-sexual-adjustment-process-of-cancer-patients-and-their-partners-a-qualitative-evidence-synthesis
#4
Charlotte Benoot, Marlies Saelaert, Karin Hannes, Johan Bilsen
When confronted with cancer, a prominent challenge for patients and their partners is their changed sexual relationship. An empirically based theoretical model of the sexual adaptation process during cancer might be helpful in guiding the development of adequate interventions for couples who struggle with their sexual relationship. Therefore, the purpose of this study was to synthesize evidence from primary qualitative research studies and to arrive at a detailed description of the process of sexual adjustment during cancer...
December 30, 2016: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/27960229/automated-telephone-communication-systems-for-preventive-healthcare-and-management-of-long-term-conditions
#5
REVIEW
Pawel Posadzki, Nikolaos Mastellos, Rebecca Ryan, Laura H Gunn, Lambert M Felix, Yannis Pappas, Marie-Pierre Gagnon, Steven A Julious, Liming Xiang, Brian Oldenburg, Josip Car
BACKGROUND: Automated telephone communication systems (ATCS) can deliver voice messages and collect health-related information from patients using either their telephone's touch-tone keypad or voice recognition software. ATCS can supplement or replace telephone contact between health professionals and patients. There are four different types of ATCS: unidirectional (one-way, non-interactive voice communication), interactive voice response (IVR) systems, ATCS with additional functions such as access to an expert to request advice (ATCS Plus) and multimodal ATCS, where the calls are delivered as part of a multicomponent intervention...
14, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27936410/body-image-and-emotional-distress-in-newly-diagnosed-cancer-patients-the-mediating-role-of-dysfunctional-attitudes-and-rumination
#6
Jianlin Liu, Chao Xu Peh, Rathi Mahendran
Body image concerns (BIC) has been reported to be associated with emotional distress for cancers across various sites. This study sought to examine two cognitive vulnerability mechanisms: dysfunctional attitudes and rumination, and their combined effects on the relationship between BIC and emotional distress in newly diagnosed Asian cancer patients. Participants were 221 newly diagnosed adult cancer patients who were assessed on BIC, rumination, dysfunctional attitudes, and emotional distress. Path analysis was used to examine the hypothesized mediation model...
December 6, 2016: Body Image
https://www.readbyqxmd.com/read/27921222/cognitive-dysfunction-in-patients-with-brain-metastases-influences-on-caregiver-resilience-and-coping
#7
Marlon Garzo Saria, Natasia Courchesne, Lorraine Evangelista, Joshua Carter, Daniel A MacManus, Mary Kay Gorman, Adeline M Nyamathi, Linda R Phillips, David Piccioni, Santosh Kesari, Sally Maliski
PURPOSE: Neurologic deficits that may be manifested as cognitive impairment contribute to the challenges faced by caregivers of patients with brain metastases. To better address their needs, we examined how caregivers respond to these challenges and explore the relationship between the patient's cognitive impairment and caregiver resilience and coping. METHODS: We conducted a descriptive, cross-sectional study using self-reported data from 56 caregivers of patients with brain metastases...
December 5, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27894012/depression-in-cancer-the-many-biobehavioral-pathways-driving-tumor-progression
#8
REVIEW
Beatrice Bortolato, Thomas N Hyphantis, Sara Valpione, Giulia Perini, Michael Maes, Gerwyn Morris, Marta Kubera, Cristiano A Köhler, Brisa S Fernandes, Brendon Stubbs, Nicholas Pavlidis, André F Carvalho
Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased mortality in the oncology setting. Advances in the understanding of neurobiological underpinnings of depression have revealed shared biobehavioral mechanisms may contribute to cancer progression. Moreover, psychosocial stressors in cancer promote: (1) inflammation and oxidative/nitrosative stress; (2) a decreased immunosurveillance; and (3) a dysfunctional activation of the autonomic nervous system and of the hypothalamic-pituitaryadrenal axis...
January 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27893174/is-there-a-relationship-between-objectively-measured-cognitive-changes-in-patients-with-solid-tumours-undergoing-chemotherapy-treatment-and-their-health-related-quality-of-life-outcomes-a-systematic-review
#9
REVIEW
Marie-Rose Dwek, Lorna Rixon, Catherine Hurt, Alice Simon, Stanton Newman
OBJECTIVE: This systematic review examines whether there is a relationship between objective measures of chemotherapy-related cognitive impairment in patients with solid cancer tumours and health related quality of life (HRQoL). METHODS: Multiple online databases were searched (including Ovid MEDLINE, EMBASE, PsycINFO, PsycARTICLES, CINAHL, PubMed and Web of Science) in order to identify articles published between 1980 and 2016 examining the extent of chemotherapy-related cognitive deficit and its relationship with HRQoL in cancer patients...
November 28, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27872469/preoperative-serum-microrna-155-expression-independently-predicts-postoperative-cognitive-dysfunction-after-laparoscopic-surgery-for-colon-cancer
#10
Chaoshuang Wu, Ruichun Wang, Xiaoyu Li, Junping Chen
BACKGROUND The aim of this study was to examine the association between serum expression of miRNA-155 and postoperative cognitive dysfunction (POCD) after laparoscopic surgery for colon cancer. MATERIAL AND METHODS We enrolled 110 patients scheduled to undergo colon tumor resection via laparotomy in Ningbo No. 2 Hospital from July 2013 to November 2015. The blood samples were collected from the participants 1 day before surgery. Multiple logistic regression analysis was used for the analysis of independent predictive biomarkers for POCD...
November 22, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27851909/systemic-cisplatin-exposure-during-infancy-and-adolescence-causes-impaired-cognitive-function-in-adulthood
#11
Tami John, Naomi Lomeli, Daniela A Bota
Cancer survivors diagnosed during infancy and adolescence may be at risk for chemotherapy-related cognitive impairments (CRCI), however the effects of pediatric chemotherapy treatment on adulthood cognitive function are not well understood. Impairments in memory, attention and executive function affect 15-50% of childhood leukemia survivors related to methotrexate exposure. Systemic cisplatin is used to treat a variety of childhood and adult cancers, yet the risk and extent of cognitive impairment due to platinum-based chemotherapy in pediatric patients is unknown...
February 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/27834803/advance-care-planning-in-glioblastoma-patients
#12
REVIEW
Lara Fritz, Linda Dirven, Jaap C Reijneveld, Johan A F Koekkoek, Anne M Stiggelbout, H Roeline W Pasman, Martin J B Taphoorn
Despite multimodal treatment with surgery, radiotherapy and chemotherapy, glioblastoma is an incurable disease with a poor prognosis. During the disease course, glioblastoma patients may experience progressive neurological deficits, symptoms of increased intracranial pressure such as drowsiness and headache, incontinence, seizures and progressive cognitive dysfunction. These patients not only have cancer, but also a progressive brain disease. This may seriously interfere with their ability to make their own decisions regarding treatment...
November 8, 2016: Cancers
https://www.readbyqxmd.com/read/27830477/association-of-thyroid-hormone-concentrations-with-quality-of-life-of-primary-brain-tumor-patients-a-pilot-study
#13
Adomas Bunevicius, Edward R Laws, Vytenis Deltuva, Arimantas Tamasauskas
Reduced triiodothyronine (T3) concentrations were implicated in worse prognosis of brain tumor patients. In this study we investigated the association of normal and abnormal thyroid hormone concentrations with health-related quality of life (HRQoL) of patients with primary brain tumors. Sixty-three patients (67% women and a mean age of 55.5 ± 13.8 years) before brain tumor surgery were evaluated for: (1) HRQoL using the EORTC questionnaire for cancer patients (QLQ-C30) and the Brain Cancer-Specific Quality of Life Questionnaire (QLQ-BN20); (2) functional status (Barthel Index); and (3) clinical disease severity...
November 9, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27816835/severe-fatigue-after-treatment-of-ductal-carcinoma-in-situ-a-comparison-with-age-matched-breast-cancer-survivors-and-healthy-controls
#14
H J G Abrahams, L Smits, M de Lugt, W K de Roos, Y Kamm, M J Heins, C A H H V M Verhagen, M F M Gielissen, H Knoop
PURPOSE: Severe fatigue after treatment of ductal carcinoma in situ (DCIS) has not been studied before. The current study examined (i) the prevalence of severe fatigue in DCIS patients versus breast cancer survivors (BCS) and healthy controls (HC), (ii) quality of life and functioning of severely versus non-severely fatigued DCIS patients and BCS, and (iii) the association of fatigue with psychosocial and behavioral factors in DCIS patients. METHODS: 89 patients treated for DCIS were matched on age and gender to 67 BCS and 178 HC (ratio 1:1:2)...
February 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27815995/impairment-of-the-executive-attention-network-in-premenopausal-women-with-hormone-receptor-positive-breast-cancer-treated-with-tamoxifen
#15
Xingui Chen, Jingjing Li, Jingjie Zhang, Xiaoxuan He, Chunyan Zhu, Lei Zhang, Xinglong Hu, Kai Wang
Tamoxifen (TAM) is most commonly prescribed for patients with hormone-sensitive breast cancer and exerts agonistic/antagonistic effects on estrogen receptors throughout the body. Accumulating evidence has revealed that breast cancer patients receiving TAM manifest cognitive dysfunction. However, whether these patients have a global attention deficit or a more selective impairment of specific attention networks remains unknown. In the present study, we sought to explore the attention function of premenopausal women with hormone receptor-positive breast cancer treated with TAM using the attention network test (ANT)...
January 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27737437/association-between-androgen-deprivation-therapy-and-risk-of-dementia
#16
Kevin T Nead, Greg Gaskin, Cariad Chester, Samuel Swisher-McClure, Nicholas J Leeper, Nigam H Shah
Importance: A growing body of evidence supports a link between androgen deprivation therapy (ADT) and cognitive dysfunction, including Alzheimer disease. However, it is currently unknown whether ADT may contribute to the risk of dementia more broadly. Objective: To use an informatics approach to examine the association of ADT as a treatment for prostate cancer with the subsequent development of dementia (eg, senile dementia, vascular dementia, frontotemporal dementia, and Alzheimer dementia)...
January 1, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/27708377/postoperative-hormonal-therapy-prevents-recovery-of-neurological-damage-after-surgery-in-patients-with-breast-cancer
#17
Atsushi Sekiguchi, Chiho Sato, Izumi Matsudaira, Yuka Kotozaki, Rui Nouchi, Hikaru Takeuchi, Masaaki Kawai, Hiroshi Tada, Takanori Ishida, Yasuyuki Taki, Noriaki Ohuchi, Ryuta Kawashima
Cancer survivors are exposed to several risk factors for cognitive dysfunction, such as general anesthesia, surgical trauma, and adjuvant therapies. In our recent study we showed that thalamic volume reduction and attentional dysfunction occurred shortly after surgery. Here, we examined the 6-month prognosis of the 20 patients with breast cancer who underwent surgery. Seven patients did not receive any adjuvant therapy after the surgery and 13 patients received a hormonal therapy after the surgery. We assessed their attentional functions, and thalamic volumes shortly after and 6 months after surgery...
October 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27690377/central-nervous-system-injury-a-newly-observed-bystander-effect-of-radiation
#18
Caitlin Feiock, Masashi Yagi, Adam Maidman, Aaron Rendahl, Susanta Hui, Davis Seelig
The unintended side effects of cancer treatment are increasing recognized. Among these is a syndrome of long-term neurocognitive dysfunction called cancer/chemotherapy related cognitive impairment. To date, all studies examining the cognitive impact of cancer treatment have emphasized chemotherapy. Radiation-induced bystander effects have been described in cell culture and, to a limited extent, in rodent model systems. The purpose of this study was to examine, for the first time, the impact of non-brain directed radiation therapy on the brain in order to elucidate its potential relationship with cancer/chemotherapy related cognitive impairment...
2016: PloS One
https://www.readbyqxmd.com/read/27637965/neuroepidemiology-of-cancer-and-treatment-related-neurocognitive-dysfunction-in-adult-onset-cancer-patients-and-survivors
#19
P Jean-Pierre, B C McDonald
Cancer and treatment-related neurocognitive dysfunction (CRND) - impairments in aspects of cognition commonly including attention and memory, information-processing speed, and executive functioning - can negatively affect patients' and survivors' participation in routine activities of daily living and overall quality of life. CRND can be enduring, and varies in severity level. The epidemiology of CRND is not yet clearly established; reported incidence has ranged from 17% to 75% among patients and survivors of noncentral nervous system malignancies, including breast, prostate, cervical, and colorectal cancers...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27629954/paraneoplastic-limbic-encephalitis-in-a-human-epidermal-growth-factor-receptor-2-positive-gastric-cancer-patient-treated-with-trastuzumab-combined-chemotherapy-a-case-report-and-literature-review
#20
Yu Uneno, Akira Yokoyama, Yoshitaka Nishikawa, Taro Funakoshi, Yoshinao Ozaki, Ikuo Aoyama, Kiichiro Baba, Daisuke Yamaguchi, Shuko Morita, Yukiko Mori, Masashi Kanai, Hisanori Kinoshita, Takeshi Inoue, Nobukatsu Sawamoto, Riki Matsumoto, Shigemi Matsumoto, Manabu Muto
Paraneoplastic neurological syndromes (PNSs) are rare nervous system dysfunctions in cancer patients, which are primarily observed with small-cell lung cancer, gynecological cancer, and thymoma. We herein present an uncommon case of PNS in an anti-Hu antibody-positive patient with human epidermal growth factor receptor (HER)-2-positive gastric cancer (GC), who developed limbic encephalitis and a worsening cognitive function. Trastuzumab-combined chemotherapy was initiated and appeared to be partially effective for controlling the neurological symptoms and tumor volume...
2016: Internal Medicine
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