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Cognitive dysfunction in cancer patients

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https://www.readbyqxmd.com/read/29785836/facing-death-alone-or-together-investigating-the-interdependence-of-death-anxiety-dysfunctional-attitudes-and-quality-of-life-in-patient-caregiver-dyads-confronting-lung-cancer
#1
Bobo Hi-Po Lau, Daniel F K Wong, Y L Fung, Jillian Zhou, Cecilia L W Chan, Amy Y M Chow
BACKGROUND: Based on the cognitive theory, anxiety arising from the awareness of death and dying may activate dysfunctional attitudes, which may then reduce quality of life. This study examined the interdependence and the mediating role of dysfunctional attitudes on the relationship between death anxiety and quality of life among patients with lung cancer and their caregivers. METHODS: From March 2016 to April 2017, 173 pairs of patients and their caregivers enrolled in a randomized controlled trial of psychosocial support...
May 21, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29779818/fighting-obesity-non-pharmacological-interventions
#2
María Fernanda Higuera-Hernández, Elena Reyes-Cuapio, Marissa Gutiérrez-Mendoza, Nuno Barbosa Rocha, André Barciela Veras, Henning Budde, Johanna Jesse, Jaime Zaldívar-Rae, Carlos Blanco-Centurión, Sérgio Machado, Eric Murillo-Rodríguez
The abnormal or excessive fat accumulation that impairs health is one of the criteria that fulfills obesity. According to epidemiological data, obesity has become a worldwide public health problem that in turn would trigger additional pathologies such as cardiorespiratory dysfunctions, cancer, gastrointestinal disturbances, depression, sleep disorders, just to mention a few. Then, the search for a therapeutical intervention aimed to prevent and manage obesity has been the focus of study during the last years...
June 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29771474/neurocog-fx-study-a-multicenter-cohort-study-on-cognitive-dysfunction-in-patients-with-early-breast-cancer
#3
Oliver Rick, Monika Reuß-Borst, Timm Dauelsberg, Holger Hass, Volker König, Reiner Caspari, Gabriele Götz-Keil, Jürgen Pfitzner, Christa Kerschgens, Klaus Fliessbach, Christian Hoppe
OBJECTIVE: Complaints about cognitive dysfunction (CD) reportedly persist in approximately one third of breast cancer patients but the nature of CD and possible risk factors are unknown. METHODS: A cross-sectional, multicenter study was set-up at 9 German oncological rehabilitation centers. Objective cognitive performance was assessed by the NeuroCog FX test, a short computerized screening (duration <30 min) which assesses working memory, alertness, verbal/figural memory and language/executive...
May 17, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29771439/remifentanil-on-t-lymphocytes-cognitive-function-and-inflammatory-cytokines-of-patients-undergoing-radical-surgery-for-cervical-cancer
#4
X-Y Lu, M Chen, D-H Chen, Y Li, P-T Liu, Y Liu
OBJECTIVE: To explore the effects of remifentanil on cognitive function, T lymphocyte subsets and inflammatory cytokines of patients undergoing radical surgery for cervical cancer. PATIENTS AND METHODS: A total of 70 patients undergoing radical surgery for cervical cancer in our hospital from August 2014 to January 2017 were selected. They were divided into control group (n=35) and experimental group (n=35). The patients in the control group received intravenous drip of fentanyl, while those in the experimental group received intravenous drip of remifentanil in the surgery...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29718081/neuropsychological-practice-in-the-oncology-setting
#5
Kyle R Noll, Mariana E Bradshaw, Jennie Rexer, Jeffrey S Wefel
Oncology has experienced positive shifts in survival curves for many cancers largely due to the development of earlier diagnostics and better therapeutics. This has increased the visibility and need for survivorship services, including clinical neuropsychology. Patients with cancer frequently experience cognitive dysfunction related to the presence of cancer itself and treatment neurotoxicity. These cognitive difficulties can profoundly impact patient functioning and autonomy with accompanying declines in quality of life...
May 1, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29710116/baseline-cognition-assessment-among-patients-with-oropharyngeal-cancer-using-promis-and-nih-toolbox
#6
Parul Sinha, Alex W K Wong, Dorina Kallogjeri, Jay F Piccirillo
Importance: Cognitive dysfunction (CD) is recognized by the American Cancer Society as a treatment effect in head and neck cancer, but the extent of this problem at baseline in oropharyngeal cancer (OPC), the most common subsite in current practice, to our knowledge has never been studied. Objective: To assess the baseline cognition of patients with OPC using National Institutes of Health (NIH)-sponsored instruments of Patient-Reported Outcomes Measurement Information System (PROMIS) and NIH Toolbox Cognitive Battery (NIHTB-CB)...
April 18, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29708996/mild-cognitive-dysfunction-of-caregivers-and-its-association-with-care-recipients-end-of-life-plans-and-preferences
#7
Keiko Kurita, Mark S Lachs, Ronald D Adelman, Eugenia L Siegler, M Cary Reid, Holly G Prigerson
Little is known about the association between cognitive dysfunction among informal caregivers and patients' plans and preferences for patients' end of life care. We report on the frequency of cognitive dysfunction among both patients and caregivers and examine associations between caregivers' cognitive screening scores and end of life plans and preferences of patients with advanced cancer. The current sample was derived from a National Cancer Institute- and National Institute of Mental Health-funded study of patients with distant metastasis who had disease progression on at least first-line chemotherapy, and their informal caregivers (n = 550 pairs)...
2018: PloS One
https://www.readbyqxmd.com/read/29703767/encephalitis-with-mglur5-antibodies-symptoms-and-antibody-effects
#8
Marianna Spatola, Lidia Sabater, Jesús Planagumà, Eugenia Martínez-Hernandez, Thaís Armangué, Harald Prüss, Takahiro Iizuka, Ruben L Caparó Oblitas, Jean-Christophe Antoine, Richard Li, Nicholas Heaney, Niall Tubridy, Elvira Munteis Olivas, Myrna R Rosenfeld, Francesc Graus, Josep Dalmau
OBJECTIVE: To report the clinical features of 11 patients with metabotropic glutamate receptor 5 (mGluR5) antibody-associated encephalitis, immunoglobulin G (IgG) subclass, and effects of the antibodies on neuronal mGluR5 clusters. METHODS: Clinical information was retrospectively obtained from referring physicians. Antibodies to mGluR5 and IgG subclasses were determined with brain immunohistochemistry and cell-based assays. The effects of the antibodies were examined on rat hippocampal neurons with reported techniques...
April 27, 2018: Neurology
https://www.readbyqxmd.com/read/29694607/clinical-and-laboratory-characteristics-associated-with-referral-of-hospitalized-elderly-to-palliative-care
#9
Suelen Pereira Arcanjo, Luis Alberto Saporetti, José Antonio Esper Curiati, Wilson Jacob-Filho, Thiago Junqueira Avelino-Silva
Objective To investigate clinical and laboratory characteristics associated with referral of acutely ill older adults to exclusive palliative care. Methods A retrospective cohort study based on 572 admissions of acutely ill patients aged 60 years or over to a university hospital located in São Paulo, Brazil, from 2009 to 2013. The primary outcome was the clinical indication for exclusive palliative care. Comprehensive geriatric assessments were used to measure target predictors, such as sociodemographic, clinical, cognitive, functional and laboratory data...
2018: Einstein
https://www.readbyqxmd.com/read/29678514/effect-of-neoadjuvant-therapy-and-rectal-surgery-on-health-related-quality-of-life-in-patients-with-rectal-cancer-during-the-first-2-years-after-diagnosis
#10
Alice M Couwenberg, Johannes P M Burbach, Wilhelmina M U van Grevenstein, Anke B Smits, Esther C J Consten, Anandi H W Schiphorst, Niels A T Wijffels, Joost T Heikens, Martijn P W Intven, Helena M Verkooijen
INTRODUCTION: Rectal cancer surgery with neoadjuvant therapy is associated with substantial morbidity. The present study describes the course of quality of life (QOL) in rectal cancer patients in the first 2 years after the start of treatment. PATIENTS AND METHODS: We performed a prospective study within a colorectal cancer cohort including rectal cancer patients who were referred for neoadjuvant chemoradiation or short-course radiotherapy and underwent rectal surgery...
March 21, 2018: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29667262/pretreatment-neurocognitive-function-and-self-reported-symptoms-in-patients-with-newly-diagnosed-head-and-neck-cancer-compared-with-noncancer-cohort
#11
Lori J Bernstein, Gregory R Pond, Hui K Gan, Kattleya Tirona, Kelvin K Chan, Andrew Hope, John Kim, Eric X Chen, Lillian L Siu, Albiruni R Abdul Razak
BACKGROUND: Newly diagnosed patients with head and neck cancer may be at risk for impaired neurocognitive function (NCF) due to disease, treatment, and lifestyle factors. METHODS: Eighty pretreatment patients with head and neck cancer and 40 control patients without cancer completed assessment of NCF and self-reported cognition, fatigue, and mood. Blood samples to evaluate organ reserves, hormones, and cytokines were collected. RESULTS: Patients experienced worse symptoms of cognitive dysfunction, fatigue, and anxiety than controls...
April 17, 2018: Head & Neck
https://www.readbyqxmd.com/read/29578249/preoperative-vitamin-d-deficiency-increases-the-risk-of-postoperative-cognitive-dysfunction-a-predefined-exploratory-sub-analysis
#12
Y Zhang, G-J Shan, Y-X Zhang, S-J Cao, S-N Zhu, H-J Li, D Ma, D-X Wang
BACKGROUND: Vitamin D is important for maintaining physiological functions including cognition and its deficiency is associated with the occurrence of cognitive impairment. This study was to explore the association between preoperative vitamin D status and the occurrence of postoperative cognitive dysfunction (POCD) in elderly patients undergoing major surgery. METHODS: This was a predefined exploratory sub-analysis of one-centre data from a randomized controlled trial...
March 26, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29538418/concordance-networks-and-application-to-clustering-cancer-symptomology
#13
Teague R Henry, Sarah A Marshall, Nancy E Avis, Beverly J Levine, Edward H Ip
Symptoms of complex illnesses such as cancer often present with a high degree of heterogeneity between patients. At the same time, there are often core symptoms that act as common drivers for other symptoms, such as fatigue leading to depression and cognitive dysfunction. These symptoms are termed bridge symptoms and when combined with heterogeneity in symptom presentation, are difficult to detect using traditional unsupervised clustering techniques. This article develops a method for identifying patient communities based on bridge symptoms termed concordance network clustering...
2018: PloS One
https://www.readbyqxmd.com/read/29525841/a-brief-psychoeducational-intervention-improves-memory-contentment-in-breast-cancer-survivors-with-cognitive-concerns-results-of-a-single-arm-prospective-study
#14
Lori J Bernstein, Graham A McCreath, Joyce Nyhof-Young, Dilan Dissanayake, Jill B Rich
PURPOSE: One in three breast cancer survivors experiences persistent cognitive changes that can negatively impact daily functioning and quality of life. In our cancer center, the largest tertiary cancer center in Canada, patients with self-reported cancer-related cognitive dysfunction (CRCD) are offered psychoeducation intended to reduce distress about CRCD symptoms and improve everyday cognitive performance, but evidence regarding this intervention's impact is lacking. Here, we assess whether a 1-hour (h), individual psychoeducational intervention designed to promote self-management of CRCD symptoms can improve attitudes and coping with memory-related difficulties in women with breast cancer...
March 10, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29496229/intravenous-lidocaine-infusion
#15
G Soto, M Naranjo González, F Calero
Systemic lidocaine used in continuous infusion during the peri-operative period has analgesic, anti-hyperalgesic, as well as anti-inflammatory properties. This makes it capable of reducing the use of opioids and inhalational anaesthetics, and the early return of bowel function, and patient hospital stay. The aim of this narrative review was to highlight the pharmacology and indications for clinical application, along with new and interesting research areas. The clinical applications of peri-operative lidocaine infusion have been reviewed in several recent systematic reviews and meta-analyses in patients undergoing open and laparoscopic abdominal procedures, ambulatory procedures, and other types of surgery...
May 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29494732/prevalence-of-cognitive-impairment-and-association-with-survival-among-older-patients-with-hematologic-cancers
#16
Tammy T Hshieh, Wooram F Jung, Laura J Grande, Jiaying Chen, Richard M Stone, Robert J Soiffer, Jane A Driver, Gregory A Abel
Importance: As the population ages, cognitive impairment has promised to become increasingly common among patients with cancer. Little is known about how specific domains of cognitive impairment may be associated with survival among older patients with hematologic cancers. Objective: To determine the prevalence of domain-specific cognitive impairment and its association with overall survival among older patients with blood cancer. Design, Setting, and Participants: This prospective observational cohort study included all patients 75 years and older who presented for initial consultation in the leukemia, myeloma, or lymphoma clinics of a large tertiary hospital in Boston, Massachusetts, from February 1, 2015, to March 31, 2017...
March 1, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29477301/physical-exercise-prevents-cognitive-impairment-by-enhancing-hippocampal-neuroplasticity-and-mitochondrial-function-in-doxorubicin-induced-chemobrain
#17
Hye-Sang Park, Chang-Ju Kim, Hyo-Bum Kwak, Mi-Hyun No, Jun-Won Heo, Tae-Woon Kim
Although chemotherapy increases the survival rate of patients with various cancers, such treatment can induce acute or long-term cognitive dysfunction a phenomenon known as post-chemotherapy cognitive impairment (PCCI) or "chemobrain." Exercise is known to positively affect brain function. Thus, the present study aimed to determine whether symptoms of chemobrain and disruptions in the neuroplasticity and functioning of hippocampal mitochondria can be prevented or relieved by exercise. Wistar rats were separated into the following groups: control, control plus exercise, chemobrain, and chemobrain plus exercise...
May 1, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29468568/cognitive-behavior-therapy-for-fear-of-cancer-recurrence-a-case-study
#18
Marieke van de Wal, Petra Servaes, Rebecca Berry, Belinda Thewes, Judith Prins
This case study describes the course and content of cognitive behavior therapy (CBT) for clinical fear of cancer recurrence (FCR) in a breast cancer survivor. The CBT for clinical FCR consisted of seven face-to-face therapy sessions and one telephone session. The primary treatment goal was to reduce FCR severity by modifying cognitive processes and dysfunctional behavior. Assessments of FCR and quality of life were completed by the breast cancer survivor pre-therapy, post-therapy, and at 6 and 12 months of post-therapy...
February 21, 2018: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/29388925/blood-will-out-vascular-contributions-to-alzheimer-s-disease
#19
REVIEW
Sidney Strickland
The fundamental pathology in Alzheimer's disease (AD) is neuronal dysfunction leading to cognitive impairment. The amyloid-β peptide (Aβ), derived from amyloid precursor protein, is one driver of AD, but how it leads to neuronal dysfunction is not established. In this Review, I discuss the complexity of AD and possible cause-and-effect relationships between Aβ and the vascular and hemostatic systems. AD can be considered a multifactorial syndrome with various contributing pathological mechanisms. Therefore, as is routinely done with cancer, it will be important to classify patients with respect to their disease signature so that specific pathologies, including vascular pathways, can be therapeutically targeted...
February 1, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29387526/performance-monitoring-in-lung-cancer-patients-pre-and-post-chemotherapy-using-fine-grained-electrophysiological-measures
#20
M Simó, A Gurtubay-Antolin, L Vaquero, J Bruna, A Rodríguez-Fornells
No previous event-related potentials (ERPs) study has explored the error-related negativity (ERN) - an ERP component indexing performance monitoring - associated to cancer and chemotherapy-induced cognitive impairment in a lung cancer population. The aim of this study was to examine differences in performance monitoring in a small-cell lung cancer group (SCLC, C +) 1-month following chemotherapy and two control groups: a non-small cell lung cancer patient group (NSCLC, C -) prior to chemotherapy and a healthy control group (HC)...
2018: NeuroImage: Clinical
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