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Cognitive dysfunction in cancer patients

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https://www.readbyqxmd.com/read/28917271/cognitive-impairment-and-chemotherapy-a-brief-overview
#1
REVIEW
Milena Vitali, Carla Ida Ripamonti, Fausto Roila, Claudia Proto, Diego Signorelli, Martina Imbimbo, Giulia Corrao, Angela Brissa, Gallucci Rosaria, Filippo de Braud, Marina Chiara Garassino, Giuseppe Lo Russo
Patients with cancer are experiencing long-term survival following chemotherapy, but the treatment may also be associated with short and long-term toxicity, including the possibility of cognitive dysfunction. A literature overview indicated a significant association between chemotherapy and cognitive impairment but prospective longitudinal research is warranted to examine the degree and persisting nature of this decline. Although chemotherapeutic agents are unlikely to cross the blood-brain barrier, it has been alleged that the occurrence of neurotoxicity is linked to the pro-inflammatory cytokine pathways...
October 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28900743/catechin-ameliorates-doxorubicin-induced-neuronal-cytotoxicity-in-in-vitro-and-episodic-memory-deficit-in-in-vivo-in-wistar-rats
#2
Sri Pragnya Cheruku, Grandhi Venkata Ramalingayya, Mallikarjuna Rao Chamallamudi, Subhankar Biswas, Krishnadas Nandakumar, Madhavan Nampoothiri, Karthik Gourishetti, Nitesh Kumar
Cognitive dysfunction by chemotherapy compromises the quality of life in cancer patients. Tea polyphenols are known chemopreventive agents. The present study was designed to evaluate the neuroprotective potential of (+) catechin hydrate (catechin), a tea polyphenol, in IMR-32 neuroblastoma cells in vitro and alleviation of episodic memory deficit in Wistar rats in vivo against a widely used chemotherapeutic agent, Doxorubicin (DOX). In vitro, neuroprotective studies were assessed in undifferentiated IMR-32 cells using percentage viability and in differentiated cells by neurite length...
September 13, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28891846/quality-of-life-in-rectal-cancer-patients-after-chemoradiation-watch-and-wait-policy-versus-standard-resection-a-matched-controlled-study
#3
Britt J P Hupkens, Milou H Martens, Jan H Stoot, Maaike Berbee, Jarno Melenhorst, Regina G Beets-Tan, Geerard L Beets, Stéphanie O Breukink
BACKGROUND: Fifteen to twenty percent of patients with locally advanced rectal cancer have a clinical complete response after chemoradiation therapy. These patients can be offered nonoperative organ-preserving treatment, the so-called watch-and-wait policy. The main goal of this watch-and-wait policy is an anticipated improved quality of life and functional outcome in comparison with a total mesorectal excision, while maintaining a good oncological outcome. OBJECTIVE: The aim of this study was to compare the quality of life of watch-and-wait patients with a matched-controlled group of patients who underwent chemoradiation and surgery (total mesorectal excision group)...
October 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28861706/xerostomia-quality-of-life-scale-xeqols-questionnaire-validation-of-italian-version-in-head-and-neck-cancer-patients
#4
Luciana Lastrucci, Silvia Bertocci, Vittorio Bini, Simona Borghesi, Roberta De Majo, Andrea Rampini, Pietro Giovanni Gennari, Paola Pernici
AIM: To translate the Xerostomia Quality-of-Life Scale (XeQoLS) into Italian language (XeQoLS-IT). Xerostomia is the most relevant acute and late toxicity in patients with head and neck cancer treated with radiotherapy (RT). Patient-reported outcome (PRO) instruments are subjective report on patient perception of health status. The XeQoLS consists of 15 items and measures the impact of salivary gland dysfunction and xerostomia on the four major domains of oral health-related QoL. METHODS: The XeQoLS-IT was created through a linguistic validation multi-step process: forward translation (TF), backward translation (TB) and administration of the questionnaire to 35 Italian patients with head and neck cancer...
August 31, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28860940/limbic-encephalitis-a%C3%A2-report-of-four-cases
#5
Żanna Pastuszak, Adam Stępień, Kazimierz Tomczykiewicz, Renata Piusińska-Macoch, Joanna Kordowska, Dariusz Galbarczyk, Jarosław Świstak
Usually limbic encephalitis (LE) is a paraneoplastic neurologic syndrome. LE symptoms can precede cancer even by a few years. Almost 50% of LE cases are connected with small cell lung carcinoma. Testis and breast cancers, granulomatous disease, thymoma, and teratomas are also often connected with LE. Other cases have infectious and autoimmunological aetiology. In LE limbic system dysfunction is observed, and it is accompanied by cerebellum and brain stem abnormalities as well as polyneuropathy. Paraneoplastic limbic encephalitis is sometimes a part of larger syndrome in which brain stem and spinal cord are involved in an inflammatory process called paraneoplastic encephalomyelitis...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28763137/cognitive-function-and-patient-reported-memory-problems-after-radiotherapy-for-cancers-at-the-skull-base-a-cross-sectional-survivorship-study-using-the-telephone-interview-for-cognitive-status-and-the-md-anderson-symptom-inventory-head-and-neck-module
#6
Chase C Hansen, Joshua B Smith, Abdallah S R Mohamed, Collin F Mulcahy, Jeffrey S Wefel, Katherine A Hutcheson, Kelsey Chrane, Jack Phan, Steven J Frank, Adam S Garden, Blaine D Smith, Hillary Eichelberger, Carthal Anderson, Colton McCoy, Marina Horiates, Conner Patrick, Sarah Floris, Chloe French, Beth M Beadle, William H Morrison, Shirley Y Su, Carol M Lewis, Michael E Kupferman, Jason M Johnson, Heath D Skinner, Stephen Y Lai, Ehab Y Hanna, David I Rosenthal, Clifton D Fuller, G Brandon Gunn
BACKGROUND: Using patient-reported and objective assessment tools, we sought to quantify cognitive symptoms and objective cognitive dysfunction in patients irradiated for skull base cancer. METHODS: Participants were assessed using the Telephone Interview for Cognitive Status (TICS) and the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN), with subsequent analysis. RESULTS: Of the 122 participants analyzed, the majority (63%) had no frank detectable cognitive impairment by TICS, with frank impairment in 6%...
August 1, 2017: Head & Neck
https://www.readbyqxmd.com/read/28721126/the-thyroid-gland-in-postmenopausal-women-physiology-and-diseases
#7
REVIEW
Małgorzata Gietka-Czernel
The incidence of most thyroid diseases: hypothyroidism, nodular goitre, and cancer is highest among postmenopausal and elderly women. The diagnosis of thyroid dysfunction in this group of patients is difficult because the symptoms can be nonspecific or common with menopausal and ageing complaints. In the interpretation of thyroid function tests the physiological changes in secretion and metabolism of thyrotropin (TSH) and thyroid hormones must be considered, as well as the influence of comorbidities. Unrecognised thyroid dysfunction leads to increased: cardiovascular risk, bone fractures, cognitive impairment, depression, and mortality...
June 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28718864/-cognitive-behavioral-group-therapy-addressing-fear-of-progression-in-cancer-out-patients
#8
Bärbel Rudolph, Alexander Wünsch, Peter Herschbach, Andreas Dinkel
Fear of progression (FoP) is an appropriate, rational response to the real threat of cancer and its treatments. However, patients experiencing elevated, dysfunctional levels of FoP often feel severely distressed and are in need of treatment. We previously conducted a (partly-)randomized controlled study with cancer patients undergoing in-patient rehabilitation and showed that a brief, four-session cognitive-behavioral group therapy significantly reduced dysfunctional FoP. In this report, we describe the adaption of the cognitive-behavioral group therapy program for use with cancer out-patients...
June 29, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28680394/abnormal-development-of-dendrites-in-adult-born-rat-hippocampal-granule-cells-induced-by-cyclophosphamide
#9
Lin Wu, Dandan Guo, Qi Liu, Fei Gao, Xiaochen Wang, Xueying Song, Fuwu Wang, Ren-Zhi Zhan
Although development of cognitive decline in cancer patients who receive chemotherapy is common, the underlying mechanism(s) remains to be identified. As abnormalities in adult hippocampal neurogenesis may serve as substrate for cognitive dysfunction, the present study examines the effect of cyclophosphamide (CPP), a widely prescribed chemotherapeutic agent, on dendritic development of adult-born hippocampal granule cells in the rat. CPP was intraperitoneally injected into male Sprague-Dawley rats once a week for four consecutive weeks...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28654153/survivorship-and-the-chronic-cancer-patient-patterns-in-treatment-related-effects-follow-up-care-and-use-of-survivorship-care-plans
#10
Melissa A Frick, Carolyn C Vachani, Christina Bach, Margaret K Hampshire, Karen Arnold-Korzeniowski, James M Metz, Christine E Hill-Kayser
BACKGROUND: The survivorship needs of patients living with chronic cancer (CC) and their use of survivorship care plans (SCPs) have been overlooked and underappreciated. METHODS: A convenience sample of 39,088 SCPs completed for cancer survivors with an Internet-based SCP tool was examined; it included 5847 CC survivors (15%; CC was defined as chronic leukemia and/or recurrent/metastatic cancer of another nature). Patient-reported treatment effects and follow-up care patterns were compared between CC survivors and survivors treated with curative intent (CI)...
June 27, 2017: Cancer
https://www.readbyqxmd.com/read/28636296/-follow-up-of-the-long-term-cancer-survivor
#11
Francesco Sciotto, Céline Py, Petros Tsantoulis
Improvements in diagnosis and treatments explain the notable increase in patients chronically affected or recovering from cancer. This is a fragile population, who is physically, psychologically and socially affected by the consequences of the disease and the associated treatments. In addition to detecting a possible relapse, oncologists and primary care physicians have to deal with a variety of issues like psychological distress, sexual dysfunction, cardiotoxicity, cognitive impairment, fatigue and, in some cases, a second primary cancer...
May 17, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28616125/mechanisms-of-neurotoxic-symptoms-as-a-result-of-breast-cancer-and-its-treatment-considerations-on-the-contribution-of-stress-inflammation-and-cellular-bioenergetics
#12
REVIEW
Tamara E Lacourt, Cobi J Heijnen
PURPOSE OF REVIEW: Breast cancer and its treatment are associated with a range of neurotoxic symptoms, such as fatigue, cognitive impairment, and pain. Although these symptoms generally subside after treatment completion, they become chronic in a significant subset of patients. We here summarize recent findings on neuroinflammation, stress, and mitochondrial dysfunction as mechanistic pathways leading to neurotoxic symptom experience in breast cancer patients and survivors. RECENT FINDINGS: Neuroinflammation related to stress or cancer treatment and stress resulting from diagnosis, treatment, or (cancer-related) worrying are important predictors of a neurotoxic symptom experience, both during and after treatment for breast cancer...
2017: Current Breast Cancer Reports
https://www.readbyqxmd.com/read/28566124/melatonin-for-prevention-of-erythema-and-oxidative-stress-in-response-to-ultraviolet-radiation
#13
Cecilie Scheuer
Skin damage induced by UVR is an escalating problem in dermatology, and increasing incidence of skin cancer, especially for non-melanoma skin cancer, has been reported worldwide. UVR from sun exposure and the production of reactive oxygen species (ROS) is known to be a pivotal factor in the aetiology of skin cancer. The pineal hormone melatonin is recognized as the most potent endogenous antioxidant. Melatonin conducts its antioxidant effects acting directly as a radical scavenger and indirectly by up regulation of antioxidant enzymes...
June 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28521365/cognitive-dysfunction-in-cancer-patients-likely-not-all-due-to-chemotherapy
#14
(no author information available yet)
No abstract text is available yet for this article.
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28521364/chemotherapy-and-post-traumatic-stress-in-the-causation-of-cognitive-dysfunction-in-breast-cancer-patients
#15
Kerstin Hermelink, Markus Bühner, Philipp Sckopke, Franziska Neufeld, Judith Kaste, Varinka Voigt, Karin Münzel, Rachel Wuerstlein, Nina Ditsch, Karin Hellerhoff, Dorothea Rjosk-Dendorfer, Michael Braun, Franz Edler von Koch, Kristin Härtl, Stephan Hasmüller, Ingo Bauerfeind, Gerlinde Debus, Peter Herschbach, Sven Mahner, Nadia Harbeck
Background: Cancer-related cognitive dysfunction has mostly been attributed to chemotherapy; this explanation, however, fails to account for cognitive dysfunction observed in chemotherapy-naïve patients. In a controlled, longitudinal, multisite study, we tested the hypothesis that cognitive function in breast cancer patients is affected by cancer-related post-traumatic stress. Methods: Newly diagnosed breast cancer patients and healthy control subjects, age 65 or younger, underwent three assessments within one year, including paper-and-pencil and computerized neuropsychological tests, clinical diagnostics of post-traumatic stress disorder (PTSD), and self-reported cognitive function...
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28504118/direct-evidence-of-central-nervous-system-axonal-damage-in-patients-with-postoperative-delirium-a-preliminary-study-of-pnf-h-as-a-promising-serum-biomarker
#16
Reo Inoue, Masahiko Sumitani, Toru Ogata, Hirotaka Chikuda, Takehiro Matsubara, So Kato, Nobutake Shimojo, Kanji Uchida, Yoshitsugu Yamada
INTRODUCTION: Approximately 50-80% patients experience postoperative delirium, an acute cognitive dysfunction associated with prolonged hospitalization, increased mortality, excess healthcare costs, and persistent cognitive impairment. Elucidation of the mechanism of delirium and associated diagnostic and therapeutic measures are urgently required. Here we investigated the role of phosphorylated neurofilament heavy subunit (pNF-H), a major structural protein in axons, as a predictive maker of postoperative delirium...
July 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28503254/management-of-potential-long-term-toxicities-in-breast-cancer-patients
#17
C C O'Sullivan, K J Ruddy
Breast cancer is the most common non-cutaneous malignancy among women, and there are over 3 million breast cancer survivors living in the United States today. Excellent cure rates with modern therapies are associated with substantial toxicities for many women; it is important that health care providers attend to the resulting symptoms and issues to optimize quality of life in this population. In this article, we review management options for potential long term toxicities in breast cancer survivors, with a particular focus on bone health, fertility preservation, premature menopause, cardiac dysfunction, and cognitive impairment...
December 2016: Current Breast Cancer Reports
https://www.readbyqxmd.com/read/28413671/paraneoplastic-limbic-encephalitis-in-a-patient-with-extensive-disease-small-cell-lung-cancer
#18
Sebastian Ochenduszko, Bartosz Wilk, Joanna Dabrowska, Izabela Herman-Sucharska, Anna Dubis, Miroslawa Puskulluoglu
Paraneoplastic limbic encephalitis (PLE) is a rare disorder infrequently accompanying malignancy, coexisting in ~50% of the cases with small-cell lung cancer (SCLC). The pathomechanism of PLE is considered to be immune-mediated, with production of specific anti-Hu antibodies and activation of T-cells directed against onconeural antigens present on both tumor cells and neurons. We herein report the case of a 50-year-old male patient who, prior to being diagnosed with SCLC, presented with typical symptoms of PLE (seizures, subacute cognitive dysfunction with severe memory impairment, anxiety and hallucinations)...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28408800/rutin-protects-against-neuronal-damage-in-vitro-and-ameliorates-doxorubicin-induced-memory-deficits-in-vivo-in-wistar-rats
#19
Grandhi Venkata Ramalingayya, Sri Pragnya Cheruku, Pawan G Nayak, Anoop Kishore, Rekha Shenoy, Chamallamudi Mallikarjuna Rao, Nandakumar Krishnadas
Doxorubicin (DOX) is the most widely used broad-spectrum anticancer agent, either alone or in combination, for most cancers including breast cancer. Long-term use of chemotherapeutic agents to treat breast cancer patients results in cognitive complications with a negative impact on survivors' quality of life. The study objective was to evaluate rutin (RUT) for its neuroprotective effect against DOX in human neuroblastoma (IMR32) cells in vitro and study its potential to ameliorate DOX-induced cognitive dysfunction in Wistar rats...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28377717/biomarkers-associated-with-cognitive-impairment-in-treated-cancer-patients-potential-predisposition-and-risk-factors
#20
REVIEW
Hélène Castel, Angeline Denouel, Marie Lange, Marie-Christine Tonon, Martine Dubois, Florence Joly
Purpose: Cognitive impairment in cancer patients induced, at least in part, by treatment are frequently observed and likely have negative impacts on patient quality of life. Such cognitive dysfunctions can affect attention, executive functions, and memory and processing speed, can persist after treatment, and their exact causes remain unclear. The aim of this review was to create an inventory and analysis of clinical studies evaluating biological markers and risk factors for cognitive decline in cancer patients before, during, or after therapy...
2017: Frontiers in Pharmacology
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