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JOURNAL ARTICLE
Jayashree P Gadade, Swaroopa A Patil
INTRODUCTION: Rotheca serrata (Lamiaceae), a highly medicinal plant is used as an antidote for snakebite and the plant possesses medicinal properties like hepatoprotective, antitussive, antioxidant, anticancer, neuro-protective, used in rheumatoid arthritis and is also a α-glucoside inhibitor. AIM OF THE STUDY: This work aimed to study the anticancerous effect of Rotheca serrata (root and leaf) on cancer cell lines MCF-7 (breast cancer cell line) and Neuroblastoma SH-SY5Y. MATERIALS AND METHODS: This investigation was a preliminary one which supported the retrospective and safe use of plants as described in Ayurveda...
January 1, 2024: Journal of Cancer Research and Therapeutics
#22
JOURNAL ARTICLE
Mahmoud Baraka, Diaa Kamal, Ahmad E Mostafa
BACKGROUND: Conduction disturbances remain one of the most common complications occurring post TAVI. We aim to determine the predictors of cardiac conduction disturbances after Transcatheter Aortic Valve Implantation (TAVI) and propose a relevant predictive model. We included 70 consecutive patients with severe symptomatic AS who underwent TAVI using the self-expanding valve Evolut R or the balloon expandable Sapien XT valve. All patients were subjected to electrocardiographic evaluation pre- and post-TAVI and at 30 days...
March 26, 2024: Indian Pacing and Electrophysiology Journal
#23
JOURNAL ARTICLE
M Salagnon, F d'Errico, S Rigaud, E Mellet
For at least 150,000 years, the human body has been culturally modified by the wearing of personal ornaments and probably by painting with red pigment. The present study used functional magnetic resonance imaging to explore the brain networks involved in attributing social status from face decorations. Results showed the fusiform gyrus, orbitofrontal cortex, and salience network were involved in social encoding, categorization, and evaluation. The hippocampus and parahippocampus were activated due to the memory and associative skills required for the task, while the inferior frontal gyrus likely interpreted face ornaments as symbols...
March 28, 2024: Brain Structure & Function
#24
REVIEW
Craig Basman, David Landers, Chad Kliger, Karla Rodriguez-Barragan, Sung-Han Yoon, Haroon Faraz, Ankitkumar Patel, Yuriy Dudiy, Mark Anderson, Ryan Kaple
A distinctive complication with balloon-expandable (BE) THV platforms such as the Edwards Sapien (Edwards Lifescience) is the possibility of balloon rupture during THV deployment. Balloon rupture is a rare occurrence that can result in stroke due to fragment embolism, incomplete THV expansion, and/or vascular injury upon retrieval of the balloon. Careful evaluation of preoperative computed tomography is essential to identify high-risk cases. While annular and left ventricular outflow tract (LVOT) calcification are widely acknowledged as common risks for balloon injury, it's essential to note that balloon injury can manifest at various anatomical sites...
March 28, 2024: Catheterization and Cardiovascular Interventions
#25
JOURNAL ARTICLE
Alessia Cavallo, Emanuela Camera, Grazia Bottillo, Miriam Maiellaro, Mauro Truglio, Federico Marini, Marlène Chavagnac-Bonneville, Aurélie Fauger, Eric Perrier, Flavia Pigliacelli, Mauro Picardo, Antonio Cristaudo, Maria Mariano
Atopic dermatitis (AD) is a composite disease presenting disruption of the skin permeability barrier (SPB) in the stratum corneum (SC). Recent evidence supports derangement of the sebaceous gland (SG) activity in the AD pathomechanisms. The objective of this study was to delineate profiles of both sebaceous and epidermal lipids and of aminoacids from SG-rich (SGR) and SG-poor (SGP) areas in AD. Both sebum and SC were sampled from SGR areas, while SC was sampled also from SGP areas in 54 adult patients with AD, consisting of 34 and 20 subjects, respectively with and without clinical involvement of face, and in 44 age and sex-matched controls...
March 2024: Experimental Dermatology
#26
JOURNAL ARTICLE
Clemens Eckel, Won-Keun Kim, Dagmar Sötemann, Christina Grothusen, Vedat Tiyerili, Guido Dohmen, Matthias Renker, Efstratios I Charitos, Christian W Hamm, Yeong-Hoon Choi, Albrecht Elsässer, Helge Möllmann, Johannes Blumenstein
BACKGROUND: Comparative data on transcatheter self-expanding ACURATE neo2 (NEO2) and balloon-expandable SAPIEN 3 Ultra prostheses in technically challenging anatomy of severe aortic valve calcified aortic annuli are scarce. METHODS: A total of 1987 patients with severe native aortic stenosis treated with the self-expanding NEO2 (n=1457) or balloon-expandable SAPIEN 3 Ultra (n=530) from January 2017 to April 2023 were evaluated. The primary end point was procedural outcome according to the Valve Academic Research Consortium 3 definitions...
March 26, 2024: Circulation. Cardiovascular Interventions
#27
JOURNAL ARTICLE
Andra Meneganzin, Grant Ramsey, James DiFrisco
The chin, a distinguishing feature of Homo sapiens, has sparked ongoing debates regarding its evolutionary origins and adaptive significance. We contend that these controversies stem from a fundamental disagreement about what constitutes a well-defined biological trait, a problem that has received insufficient attention despite its recognized importance in biology. In this paper, we leverage paleoanthropological research on the human chin to investigate the general issue of character or trait identification...
March 2024: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
#28
JOURNAL ARTICLE
Rob Eerdekens, Suzanne Kats, Janneke Pc Grutters, Michelle Green, Judith Shore, Pascal Candolfi, Wija Oortwijn, Pim Van Der Harst, Pim Tonino
BACKGROUND: There is growing evidence to support the benefits of transcatheter aortic valve implantation (TAVI) over surgical aortic valve replacement (SAVR) in patients with symptomatic severe aortic stenosis (sSAS) who are at high- or intermediate-risk of surgical mortality. The PARTNER 3 trial showed clinical benefits with SAPIEN 3 TAVI compared with SAVR in patients at low risk of surgical mortality. Whether TAVI is also cost-effective compared with SAVR for low-risk patients in the Dutch healthcare system remains uncertain...
March 26, 2024: Cost Effectiveness and Resource Allocation: C/E
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JOURNAL ARTICLE
Leonardo Vallini, Carlo Zampieri, Mohamed Javad Shoaee, Eugenio Bortolini, Giulia Marciani, Serena Aneli, Telmo Pievani, Stefano Benazzi, Alberto Barausse, Massimo Mezzavilla, Michael D Petraglia, Luca Pagani
A combination of evidence, based on genetic, fossil and archaeological findings, indicates that Homo sapiens spread out of Africa between ~70-60 thousand years ago (kya). However, it appears that once outside of Africa, human populations did not expand across all of Eurasia until ~45 kya. The geographic whereabouts of these early settlers in the timeframe between ~70-60 to 45 kya has been difficult to reconcile. Here we combine genetic evidence and palaeoecological models to infer the geographic location that acted as the Hub for our species during the early phases of colonisation of Eurasia...
March 25, 2024: Nature Communications
#30
JOURNAL ARTICLE
Georgios Chalikias, Soultana Foutzitzi, Dimitrios Stakos, Dimitrios Tziakas
An 83-year-old man with severe aortic stenosis underwent implantation of a 29-mm SAPIEN-3 (Edwards Lifesciences) transcatheter aortic valve (TAV) appropriately sized for an aortic annulus area of 543.6 mm2.
March 19, 2024: Journal of Invasive Cardiology
#31
Kazuki Mizutani, Masafumi Ueno, Genichi Sakaguchi, Gaku Nakazawa
BACKGROUND: There are a few case reports regarding transcatheter aortic valve implantation (TAVI) for deteriorated surgical homograft. CASE SUMMARY: We present a case of severe structural valve deterioration (SVD) of homograft surgical aortic valve presenting severe aortic regurgitation in an 84-year-old man with decompensated heart failure. We performed TAVI in homograft valve using 23 mm SAPIEN3 Ultra RESILIA. The resulting grade of paravalvular regurgitation was trace, the post-operative effective orifice area (EOA) was 1...
March 2024: European Heart Journal. Case Reports
#32
REVIEW
Héctor Marín Manrique, Karl John Friston, Michael John Walker
A paradigmatic account may suffice to explain behavioral evolution in early Homo. We propose a parsimonious account that (1) could explain a particular, frequently-encountered, archeological outcome of behavior in early Homo - namely, the fashioning of a Paleolithic stone 'handaxe' - from a biological theoretic perspective informed by the free energy principle (FEP); and that (2) regards instances of the outcome as postdictive or retrodictive, circumstantial corroboration. Our proposal considers humankind evolving as a self-organizing biological ecosystem at a geological time-scale...
January 21, 2024: Physics of Life Reviews
#33
JOURNAL ARTICLE
Sabina Yasmin, Mohmmad Yousuf Ansari, Krishna Pandey, Manas Ranjan Dikhit
The COVID-19 pandemic has emerged as a critical global health crisis, demanding urgent and effective strategies for containment. While some knowledge exists about epitope sequences recognized by human immune cells and their activation of CD8+ T cells within the HLA context, comprehensive information remains limited. This study employs reverse vaccinology to explore antigenic HLA-restricted T-cell epitopes capable of eliciting durable immunity. Screening reveals 187 consensus epitopes, with 23 offering broad population coverage worldwide, spanning over 5000 HLA alleles...
March 18, 2024: International Journal of Biological Macromolecules
#34
JOURNAL ARTICLE
David Meier, Daire Grant, Chris Frawley, Mariama Akodad, Uri Landes, Arif A Kokhar, Dariusz Dudek, Isaac George, Michael J Rinaldi, Won-Keun Kim, Steven J Yakubov, Paul Sorajja, Giuseppe Tarantini, David A Wood, John G Webb, Stephanie L Sellers, Janarthanan Sathananthan
BACKGROUND: There are limited data regarding treatment for failed balloon-expandable transcatheter heart valves (THVs) in redo-transcatheter aortic valve implantation (TAVI). AIMS: We aimed to assess THV performance, neoskirt height and expansion when performing redo-TAVI with the ACURATE platform inside a SAPIEN 3 (S3) compared to redo-TAVI with an S3 in an S3. METHODS: Redo-TAVI was performed on the bench using each available size of the S3, the ACURATE neo2 (ACn2) and the next-generation ACURATE Prime XL (AC XL) implanted at 2 different depths within 20 mm/23 mm/26 mm/29 mm S3s serving as the "failed" index THV...
March 18, 2024: EuroIntervention
#35
JOURNAL ARTICLE
Anoop N Koshy, Gilbert H L Tang, Sahil Khera, Manish Vinayak, Megan Berdan, Sneha Gudibendi, Amit Hooda, Lucy Safi, Stamatios Lerakis, George D Dangas, Samin K Sharma, Annapoorna S Kini, Parasuram Krishnamoorthy
BACKGROUND: Redo-transcatheter aortic valve replacement (TAVR) can pin the index transcatheter heart valve leaflets open leading to sinus sequestration and restricting coronary access. The impact of initial implant depth and commissural alignment on redo-TAVR feasibility is unclear. We sought to determine the feasibility of redo-TAVR and coronary access after SAPIEN 3 (S3) TAVR stratified by implant depth and commissural alignment. METHODS: Consecutive patients with native valve aortic stenosis were evaluated using multidetector computed tomography...
March 2024: Circulation. Cardiovascular Interventions
#36
Victor H Molina-Lopez, Eduardo Partida-Rodriguez, Jaime Rivera-Babilonia, Luis Rodriguez-Ospina
This study examines a complex scenario of structural valve degeneration (SVD) in a high surgical-risk patient with a previously implanted 25 mm Carpentier-Edwards (CE) Perimount Magna Ease 3300 (Irvine, CA: Edwards Lifesciences) surgical bioprosthetic valve (SAV), the patient presented with both paravalvular leak (PVL) and central prosthetic valve insufficiency (PVI). The patient was considered for a transaortic valve-in-valve (ViV) intervention with a self-expanding 29 mm Evolut R valve (Minneapolis, MN: Medtronic)...
February 2024: Curēus
#37
REVIEW
Paul M Wassarman, Eveline S Litscher
All mammalian eggs are surrounded by a relatively thick extracellular matrix (ECM) or zona pellucida (ZP) to which free-swimming sperm bind in a species-restricted manner during fertilization. The ZP consists of either three (e.g., Mus musculus ) or four (e.g., Homo sapiens ) glycosylated proteins, called ZP1-4. These proteins are unlike those found in somatic cell ECM, are encoded by single-copy genes on different chromosomes, and are well conserved among different mammals. Mammalian ZP proteins are synthesized as polypeptide precursors by growing oocytes that will become ovulated, unfertilized eggs...
March 4, 2024: Histology and Histopathology
#38
JOURNAL ARTICLE
Yang Li, Yizhong Wang, Cankun Wang, Anjun Ma, Qin Ma, Bingqiang Liu
In this study, we introduce TESA (weighted two-stage alignment), an innovative motif prediction tool that refines the identification of DNA-binding protein motifs, essential for deciphering transcriptional regulatory mechanisms. Unlike traditional algorithms that rely solely on sequence data, TESA integrates the high-resolution chromatin immunoprecipitation (ChIP) signal, specifically from ChIP-exonuclease (ChIP-exo), by assigning weights to sequence positions, thereby enhancing motif discovery. TESA employs a nuanced approach combining a binomial distribution model with a graph model, further supported by a "bookend" model, to improve the accuracy of predicting motifs of varying lengths...
March 8, 2024: Patterns
#39
JOURNAL ARTICLE
Viktória Stanová, Régis Rieu, Lionel Thollon, Erwan Salaun, Josep Rodés-Cabau, Nancy Côté, Diego Mantovani, Philippe Pibarot
BACKGROUND: It is unknown whether bioprostheses used for transcatheter aortic valve implantation will have similar long-term durability as those used for surgical aortic valve replacement. Repetitive mechanical stress applied to the valve leaflets, particularly during diastole, is the main determinant of structural valve deterioration. Leaflet mechanical stress cannot be measured in vivo. The objective of this in vitro/in silico study was thus to compare the magnitude and regional distribution of leaflet mechanical stress in old vs new generations of self-expanding (SE) vs balloon expandable (BE) transcatheter heart valves (THVs)...
March 2024: Structural heart: the journal of the Heart Team
#40
JOURNAL ARTICLE
Andrea Scotti, Matteo Sturla, Giuliano Costa, Francesco Saia, Thomas Pilgrim, Mohamed Abdel-Wahab, Philippe Garot, Caterina Gandolfo, Luca Branca, Ignacio Amat Santos, Darren Mylotte, Francesco Bedogni, Ole De Backer, Luis Nombela Franco, John Webb, Flavio Luciano Ribichini, Andrea Mainardi, Stefano Andreaggi, Alessandro Mazzapicchi, Daijiro Tomii, Pietro Laforgia, Stefano Cannata, Claudia Fiorina, Simone Fezzi, Enrico Criscione, Mattia Lunardi, Enrico Poletti, Mattia Mazzucca, Angelo Quagliana, Nicholas Montarello, Breda Hennessey, Matias Mon-Noboa, Myriam Akodad, David Meier, Federico De Marco, Marianna Adamo, Carmelo Sgroi, Claudia Maria Reddavid, Roberto Valvo, Orazio Strazzieri, Silvia Crescenzia Motta, Valentina Frittitta, Elena Dipietro, Alessandro Comis, Chiara Melfa, Mariachiara Calì, Sofia Sammartino, Giulia Laterra, Holger Thiele, Lars Sondergaard, Corrado Tamburino, Marco Barbanti, Azeem Latib
BACKGROUND: The performance of latest iteration transcatheter aortic valve replacement platforms in patients with small aortic anatomy remains underexplored. OBJECTIVES: The aim of this study was to evaluate effectiveness and performance between the self-expanding (SE) Evolut PRO and PRO+ and the balloon-expandable (BE) SAPIEN ULTRA in patients with small aortic annuli. METHODS: Data from the OPERA-TAVI (Comparative Analysis of Evolut PRO vs...
March 11, 2024: JACC. Cardiovascular Interventions
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