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https://www.readbyqxmd.com/read/28916901/pulmonic-valve-disease-review-of-pathology-and-current-treatment-options
#1
REVIEW
Mouhammad Fathallah, Richard A Krasuski
PURPOSE OF REVIEW: Our review is intended to provide readers with an overview of disease processes involving the pulmonic valve, highlighting recent outcome studies and guideline-based recommendations; with focus on the two most common interventions for treating pulmonic valve disease, balloon pulmonary valvuloplasty and pulmonic valve replacement. RECENT FINDINGS: The main long-term sequelae of balloon pulmonary valvuloplasty, the gold standard treatment for pulmonic stenosis, remain pulmonic regurgitation and valvular restenosis...
September 16, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28902917/hsp70-j-protein-machinery-from-glossina-morsitans-morsitans-vector-of-african-trypanosomiasis
#2
Stephen J Bentley, Aileen Boshoff
Tsetse flies (Glossina spp.) are the sole vectors of the protozoan parasites of the genus Trypanosoma, the causative agents of African Trypanosomiasis. Species of Glossina differ in vector competence and Glossina morsitans morsitans is associated with transmission of Trypanosoma brucei rhodesiense, which causes an acute and often fatal form of African Trypanosomiasis. Heat shock proteins are evolutionarily conserved proteins that play critical roles in proteostasis. The activity of heat shock protein 70 (Hsp70) is regulated by interactions with its J-protein (Hsp40) co-chaperones...
2017: PloS One
https://www.readbyqxmd.com/read/28902417/genetic-variants-related-to-disease-susceptibility-and-immunotolerance-in-the-duffy-antigen-receptor-for-chemokines-darc-fy-gene-in-the-black-lion-tamarin-leontopithecus-chrysopygus-primates
#3
Ashley Ansel, James D Lewis, Don J Melnick, Cristiana Martins, Claudio Valladares-Padua, Beatriz Perez-Sweeney
The DARC (Duffy antigen receptor for chemokines) gene encodes the DARC protein, which serves multiple roles in the immune system, as a binding site for the malarial parasites Plasmodium vivax and Plasmodium knowlesi, a promiscuous chemokine receptor and a blood group antigen. Variation in DARC may play particularly significant roles in innate immunity, immunotolerance and pathogen entry in callitrichines, such as the black lion tamarin (Leontopithecus chrysopygus). We compared amino acid sequences of DARC in the black lion tamarin (BLT) to non-human Haplorhine primates and Homo sapiens...
September 13, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28895301/early-leaflet-thrombosis-complicating-transcatheter-implantation-of-a-sapien-3-valve-in-a-native-right-ventricular-outflow-tract
#4
Mounir Riahi, Philipp Blanke, John Webb, Ronald G Carere
A 59-year-old female with Tetralogy of Fallot had a previous complete repair with RVOT patch enlargement. She developed subsequent severe symptomatic (NYHA III) pulmonary regurgitation with severe RV dilatation. She had a concomitant interstitial lung disease secondary to hypersensitivity pneumonitis that precluded her from cardiac surgery. After preprocedural assessment using computed tomography, echocardiography and invasive angiography we decided to implant a 29 mm Edwards Sapien 3 valve without pre-stenting...
September 12, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28895283/right-ventricle-outflow-tract-prestenting-in-vitro-testing-of-rigidity-and-corrosion-properties
#5
Bjorn Cools, Stephen Brown, Martine Wevers, Jan Van Humbeeck, Derize Boshoff, Cis Verdonckt, Marc Gewillig
BACKGROUND: The aim of this study was to assess the resistance to compression (stiffness) of frequently used stents for right ventricular outflow tract prestenting. In addition, to assess the corrosion potential when different types of stent alloys come into contact with each other. METHOD: Different stents were tested in vitro in various combinations at specialized metallurgic laboratories. A bench compression test was used to assess resistance to compression of singular and joined combinations of stents...
September 12, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28893204/predicted-networks-of-protein-protein-interactions-in-stegodyphus-mimosarum-by-cross-species-comparisons
#6
Xiu Wang, Yongfeng Jin
BACKGROUND: Stegodyphus mimosarum is a candidate model organism belonging to the class Arachnida in the phylum Arthropoda. Studies on the biology of S. mimosarum over the past several decades have consisted of behavioral research and comparison of gene sequences based on the assembled genome sequence. Given the lack of systematic protein analyses and the rich source of information in the genome, we predicted the relationships of proteins in S. mimosarum by bioinformatics comparison with genome-wide proteins from select model organisms using gene mapping...
September 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28886064/sexcmd-development-and-validation-of-sex-marker-sequences-for-whole-exome-genome-and-rna-sequencing
#7
Seongmun Jeong, Jiwoong Kim, Won Park, Hongmin Jeon, Namshin Kim
Over the last decade, a large number of nucleotide sequences have been generated by next-generation sequencing technologies and deposited to public databases. However, most of these datasets do not specify the sex of individuals sampled because researchers typically ignore or hide this information. Male and female genomes in many species have distinctive sex chromosomes, XX/XY and ZW/ZZ, and expression levels of many sex-related genes differ between the sexes. Herein, we describe how to develop sex marker sequences from syntenic regions of sex chromosomes and use them to quickly identify the sex of individuals being analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28885378/radial-force-an-underestimated-parameter-in-oversizing-transcatheter-aortic-valve-replacement-prostheses-in-vitro-analysis-with-five-commercialized-valves
#8
Sandrine Egron, Buntaro Fujita, Lucía Gullón, Pott Désirée, Thomas Schmitz-Rode, Stephan Ensminger, Ulrich Steinseifer
The goal is to inform in depth on transcatheter aortic valve replacement (TAVR) prosthesis mechanical behavior, depending on frame type, design, and size, and how it crucially impacts the oversizing issue in clinical use, and ultimately the procedure outcome. Transcatheter aortic valve replacement is an established therapy for high-risk patients suffering from aortic stenosis, and the indication for TAVR is progressively expanding to intermediate-risk patients. Choosing the optimal oversizing degree is crucial to safely anchor the TAVR valve-which involves limiting the risks for embolism, aortic regurgitation, conductance disturbance, or annulus rupture-and to increase the valve prosthesis performance...
September 5, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28879580/plant-and-animal-micrornas-mirnas-and-their-potential-for-inter-kingdom-communication
#9
REVIEW
Yuhai Zhao, Lin Cong, Walter J Lukiw
microRNAs (miRNAs) comprise a class of ~18-25 nucleotide (nt) single-stranded non-coding RNAs (sncRNAs) that are the smallest known carriers of gene-encoded, post-transcriptional regulatory information in both plants and animals. There are many fundamental similarities between plant and animal miRNAs-the miRNAs of both kingdoms play essential roles in development, aging and disease, and the shaping of the transcriptome of many cell types. Both plant and animal miRNAs appear to predominantly exert their genetic and transcriptomic influences by regulating gene expression at the level of messenger RNA (mRNA) stability and/or translational inhibition...
September 6, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28878583/balloon-repositioning-of-transcatheter-aortic-valve-after-migration-into-the-left-ventricular-outflow-tract-followed-by-valve-in-valve-procedure
#10
Masaki Ito, Norio Tada, Masaki Hata
Transcatheter aortic valve replacement is an established option for treating patients with symptomatic aortic stenosis; however, severe, life-threatening complications, such as valve migration, are possible. We report the case of an 82-year-old woman whose Edwards Sapien XT valve migrated into the left ventricular outflow tract one day after transcatheter aortic valve replacement. We used an inflated balloon to adjust the position of the migrated valve before performing a valve-in-valve procedure via a transapical approach, which resulted in a good valve implantation...
August 2017: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/28878582/transcatheter-mitral-valve-replacement-with-the-edwards-sapien-3-valve
#11
Biswajit Kar, Angelo Nascimbene, Igor D Gregoric, Manish Patel, Pranav Loyalka
We describe the case of a 57-year-old man who had severe mitral valve stenosis and regurgitation without significant annular calcification. He was not a candidate for surgical valve replacement or repair because of his substantial comorbid conditions, overall frailty, and elevated surgical risk. He underwent successful transcatheter mitral valve replacement of his native mitral valve with compassionate, off-label use of an Edwards Sapien 3 valve. A search of the literature produced no other cases like ours, which represents a further evolution of the transcatheter valve implantation concept...
August 2017: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/28865772/expression-of-myosin-heavy-chain-isoforms-mrna-transcripts-in-the-temporalis-muscle-of-common-chimpanzees-pan-troglodytes
#12
Neus Ciurana, Rosa Artells, Carmen Muñoz, Júlia Arias-Martorell, Gaëlle Bello-Hellegouarch, Aroa Casado, Elisabeth Cuesta, Alejandro Pérez-Pérez, Juan Francisco Pastor, Josep Maria Potau
PURPOSE: The common chimpanzee (Pan troglodytes) is the primate that is phylogenetically most closely related to humans (Homo sapiens). In order to shed light on the anatomy and function of the temporalis muscle in the chimpanzee, we have analyzed the expression patterns of the mRNA transcripts of the myosin heavy chain (MyHC) isoforms in different parts of the muscle. BASIC PROCEDURES: We dissected the superficial, deep and sphenomandibularis portions of the temporalis muscle in five adult P...
August 30, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28864021/the-core-transcriptome-of-mammalian-placentas-and-the-divergence-of-expression-with-placental-shape
#13
Don L Armstrong, Michael R McGowen, Amy Weckle, Priyadarshini Pantham, Jason Caravas, Dalen Agnew, Kurt Benirschke, Sue Savage-Rumbaugh, Eviatar Nevo, Chong J Kim, Günter P Wagner, Roberto Romero, Derek E Wildman
INTRODUCTION: The placenta is arguably the most anatomically variable organ in mammals even though its primary function is conserved. METHOD: Using RNA-Seq, we measured the expression profiles of 55 term placentas of 14 species of mammals representing all major eutherian superordinal clades and marsupials, and compared the evolution of expression across clades. RESULTS: We identified a set of 115 core genes which is expressed (FPKM ≥10) in all eutherian placentas, including genes with immune-modulating properties (ANXA2, ANXA1, S100A11, S100A10, and LGALS1), cell-cell interactions (LAMC1, LUM, and LGALS1), invasion (GRB2 and RALB) and syncytialization (ANXA5 and ANXA1)...
September 2017: Placenta
https://www.readbyqxmd.com/read/28860640/free-mate-choice-does-not-influence-reproductive-success-in-humans
#14
Piotr Sorokowski, Agata Groyecka, Maciej Karwowski, Upma Manral, Amit Kumar, Agnieszka Niemczyk, Michalina Marczak, Michał Misiak, Agnieszka Sorokowska, Thomas Huanca, Esther Conde, Bogdan Wojciszke, Bogusław Pawłowski
The effect of free mate choice on the relative magnitude of fitness benefits has been examined among various species. The majority of the data show significant fitness benefits of mating with partners of an individual's own choice, highlighting elevated behavioral compatibility between partners with free mate choice. Similarities between humans and other species that benefit from free mate choice led us to hypothesize that it also confers reproductive benefits in Homo sapiens. To test this hypothesis, we conducted a study among three indigenous societies-the Tsimane', Yali, and Bhotiya-who employ natural birth control...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28860004/lox-1-a-potential-target-for-therapy-in-atherosclerosis-an-in-vitro-study
#15
Albina Arjuman, Nimai C Chandra
Pro-inflammatory signal generated from the interaction of oxLDL with its cognate receptor LOX-1 has been attenuated successfully by a novel combination siRNA (siLOX-1(Ω)) targeting unique regions of Homo sapien LOX-1 mRNA. Signalling via LOX-1R was studied in a potentially pro-atherogenic arena recreated in a metabolic, pulse-chase set up. An initial pulse of oxLDL (20μg/mL;5h) was chased (without oxLDL) on a temporal scale upto 72h. Our study shows that the pro-inflammatory signal generated via oxLDL-LOX-1R interaction was mediated in two rungs, an initial sustained increase in LOX-1R expression up to 12h, and a renewal after 48h...
August 30, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28854258/temporal-variation-in-black-caiman-nest-predation-in-varzea-of-central-brazilian-amazonia
#16
Kelly Torralvo, Robinson Botero-Arias, William E Magnusson
On the Amazon floodplain, the main predators of black caiman (Melanosuchus niger) eggs are jaguars (Panthera onca), tegu lizards (Tupinambis teguixim), capuchin monkeys (Sapajus macrocephalus) and humans (Homo sapiens). In this study, we investigated the relationship between predator attacks on nests and incubation period, and evaluated the influence of initial predation on subsequent predation in the Mamirauá Sustainable Development Reserve. We also evaluated the influence of presence of females near the nests and manipulation of nests on the occurrence of attacks...
2017: PloS One
https://www.readbyqxmd.com/read/28840376/molecular-characterization-of-transport-lectin-vesicular-integral-membrane-protein-36%C3%A2-kda-vip36-in-the-life-cycle-of-schistosoma-mansoni
#17
Alice Maria de M Ornelas, Renato G de Paula, Enyara R Morais, Lizandra G Magalhães, Annielle M B da Silva, Matheus S Gomes, William de Castro-Borges, Vanderlei Rodrigues
VIP36 is a protein described as an L-type lectin in animals, responsible for the intracellular transport of glycoproteins within the secretory pathway, and also localized on the plasma membrane. Schistosoma mansoni has a complex system of vesicles and protein transport machinery to the cell surface. The excreted/secreted products of the larvae and eggs are known to be exposed to the host immune system. Hence, characterizing the role and action of SmVIP36 in the S. mansoni life cycle is important for a better understanding of the parasite-host relationship...
August 24, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28839917/human-niche-human-behaviour-human-nature
#18
REVIEW
Agustin Fuentes
The concept of a 'human nature' or 'human natures' retains a central role in theorizing about the human experience. In Homo sapiens it is clear that we have a suite of capacities generated via our evolutionary past, and present, and a flexible capacity to create and sustain particular kinds of cultures and to be shaped by them. Regardless of whether we label these capacities 'human natures' or not, humans occupy a distinctive niche and an evolutionary approach to examining it is critical. At present we are faced with a few different narratives as to exactly what such an evolutionary approach entails...
October 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28836337/overexpansion-of-the-29-mm-sapien-3-transcatheter-heart-valve-in-patients-with-large-aortic-annuli-area-%C3%A2-683-mm-2-a-case-series
#19
Moses Mathur, James M McCabe, Gabriel Aldea, Jay Pal, Creighton W Don
OBJECTIVES: To evaluate overexpanded 29 mm SAPIEN (S3) transcatheter heart valves in patients with aortic annuli area >683 mm(2) . BACKGROUND: The largest valve area the 29 mm S3 is specified for is 683 mm(2) . Valve overexpansion has been performed in patients with larger aortic annuli, but data are limited. Moreover, feasibility in areas >740 mm(2) is unknown. METHODS: All 29 mm S3 transcatheter aortic valve replacements (TAVR) at a single center over 23-months were retrospectively reviewed...
August 24, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28832938/energetic-cost-of-walking-in-fossil-hominins
#20
M Vidal-Cordasco, A Mateos, G Zorrilla-Revilla, O Prado-Nóvoa, J Rodríguez
OBJECTIVE: Many biomechanical studies consistently show that a broader pelvis increases the reaction forces and bending moments across the femoral shaft, increasing the energetic costs of unloaded locomotion. However, a biomechanical model does not provide the real amount of metabolic energy expended in walking. The aim of this study is to test the influence of pelvis breadth on locomotion cost and to evaluate the locomotion efficiency of extinct Pleistocene hominins. MATERIAL AND METHODS: The current study measures in vivo the influence of pelvis width on the caloric cost of locomotion, integrating anthropometry, body composition and indirect calorimetry protocols in a sample of 46 subjects of both sexes...
August 19, 2017: American Journal of Physical Anthropology
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