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https://www.readbyqxmd.com/read/29779738/culture-and-art-importance-of-art-practice-not-aesthetics-to-early-human-culture
#1
Dahlia W Zaidel
Art is expressed in multiple formats in today's human cultures. Physical traces of stone tools and other archaeological landmarks suggest early nonart cultural behavior and symbolic cognition in the early Homo sapiens (HS) who emerged ~300,000-200,000 years ago in Africa. Fundamental to art expression is the neural underpinning for symbolic cognition, and material art is considered its prime example. However, prior to producing material art, HS could have exploited symbolically through art-rooted biological neural pathways for social purpose, namely, those controlling interpersonal motoric coordination and sound codependence...
2018: Progress in Brain Research
https://www.readbyqxmd.com/read/29774980/edwards-sapien-xt%C3%A2-pulmonic-valve-compression-after-resuscitation-and-successful-redilatation
#2
Anja Lehner, Marinos Kantzis, Nikolaus A Haas
Despite the increasing use of percutaenous valves, little is known about valve performance after external chest compression. We report a case of a compressed pulmonary Edwards Sapien® XT valve after resuscitation. With the patient on ECMO, successful redilatation was performed with unimpaired postprocedural valve function. We aim to increase the awareness for valve distortion after external chest compression with increasing numbers of transcatheter valvulations. We suggest that immediate re-evaluation of the implanted device via biplane fluoroscopy is mandatory after resuscitation in such cases...
May 18, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29767663/cox-2-gene-expression-and-methylation-profile-in-sapajus-apella-as-an-experimental-model-for-gastric-adenocarcinoma
#3
Danilo do Rosário Pinheiro, Maria Lucia Harada, Rommel Mario Rodriguez Burbano, Barbara do Nascimento Borges
Gastric cancer (GC) remains one of the main causes of cancer-related death worldwide. There are two distinct histological types of GC: diffuse and intestinal. The latter is characterized by the presence of pre-neoplastic lesions. One of the most frequently altered enzymes in intestinal GC is COX-2, an important lesion marker. This work aimed to study COX-2 methylation and expression in N-methyl-N-Nitrosurea (MNU)-induced intestinal GC in six Sapajus apella animals. The partial promoter sequence of S. apella COX-2 gene was obtained and used to identify transcription factors and cis-regulatory element binding sites...
May 14, 2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29765111/new-insights-into-apoptosome-structure-and-function
#4
REVIEW
Loretta Dorstyn, Christopher W Akey, Sharad Kumar
The apoptosome is a platform that activates apical procaspases in response to intrinsic cell death signals. Biochemical and structural studies in the past two decades have extended our understanding of apoptosome composition and structure, while illuminating the requirements for initiator procaspase activation. A number of studies have now provided high-resolution structures for apoptosomes from C. elegans (CED-4), D. melanogaster (Dark), and H. sapiens (Apaf-1), which define critical protein interfaces, including intra and interdomain interactions...
May 15, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29763729/in-silico-identification-of-molecular-mimics-involved-in-the-pathogenesis-of-clostridium-botulinum-atcc-3502-strain
#5
Tulika Bhardwaj, Shafiul Haque, Pallavi Somvanshi
Bacterial pathogens invade and disrupt the host defense system by means of protein sequences structurally similar at global and local level both. The sharing of homologous sequences between the host and the pathogenic bacteria mediates the infection and defines the concept of molecular mimicry. In this study, various computational approaches were employed to elucidate the pathogenicity of Clostridium at genome-wide level. Genome-wide study revealed that the pathogen mimics the host (Homo sapiens) and unraveled the complex pathogenic pathway of causing infections...
May 12, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29762934/rescue-tavi-for-aortic-regurgitation-after-left-ventricular-assist-device-implantation-following-preoperative-impella%C3%A2-support
#6
Florian E M Herrmann, Petra Wellmann, Vera von Dossow, Steffen Massberg, Christian Hagl, René Schramm, Maximilian Pichlmaier
A patient presented with a decompensated cardiomyopathy requiring invasive hemodynamic support with an Impella® heart pump. Extracorporeal life support (ECLS) became necessary during the further course and the patient was bridged to left ventricular assist device (LVAD) implantation. Postoperatively, the patient did not improve as expected due to new aortic regurgitation (AR) that was most likely caused by the previously placed Impella. A SAPIEN 3 transcatheter aortic valve was implanted as a bail-out strategy; an additional valve-in-valve rescue was required due to paravalvular regurgitation...
September 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29761520/predicting-lysine-malonylation-sites-of-proteins-using-sequence-and-predicted-structural-features
#7
Ghazaleh Taherzadeh, Yuedong Yang, Haodong Xu, Yu Xue, Alan Wee-Chung Liew, Yaoqi Zhou
Malonylation is a recently discovered post-translational modification (PTM) in which a malonyl group attaches to a lysine (K) amino acid residue of a protein. In this work, a novel machine learning model, SPRINT-Mal, is developed to predict malonylation sites by employing sequence and predicted structural features. Evolutionary information and physicochemical properties are found to be the two most discriminative features whereas a structural feature called half-sphere exposure provides additional improvement to the prediction performance...
May 14, 2018: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29753441/a-new-tephrochronology-for-early-diverse-stone-tool-technologies-and-long-distance-raw-material-transport-in-the-middle-to-late-pleistocene-kapthurin-formation-east-africa
#8
Nick Blegen, Brian R Jicha, Sally McBrearty
The Middle to Late Pleistocene (780-10 ka) of East Africa records evidence of significant behavioral change, early fossils of Homo sapiens, and the dispersals of our species across and out of Africa. Studying human evolution in this time period thus requires an extensive and precise chronology relating behavioral evidence from archaeological sequences to aspects of hominin biology and evidence of past environments from fossils and geological sequences. Tephrochronology provides the chronostratigraphic resolution to achieve this through correlation and dating of volcanic ashes...
May 9, 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29750793/correction-self-domestication-in-homo-sapiens-insights-from-comparative-genomics
#9
Constantina Theofanopoulou, Simone Gastaldon, Thomas O'Rourke, Bridget D Samuels, Pedro Tiago Martins, Francesco Delogu, Saleh Alamri, Cedric Boeckx
[This corrects the article DOI: 10.1371/journal.pone.0185306.].
2018: PloS One
https://www.readbyqxmd.com/read/29748625/sea-lions-develop-human-like-vernix-caseosa-delivering-branched-fats-and-squalene-to-the-gi-tract
#10
Dong Hao Wang, Rinat Ran-Ressler, Judy St Leger, Erika Nilson, Lauren Palmer, Richard Collins, J Thomas Brenna
Vernix caseosa, the white waxy coating found on newborn human skin, is thought to be a uniquely human substance. Its signature characteristic is exceptional richness in saturated branched chain fatty acids (BCFA) and squalene. Vernix particles sloughed from the skin suspended in amniotic fluid are swallowed by the human fetus, depositing BCFA/squalene throughout the gastrointestinal (GI) tract, thereby establishing a unique microbial niche that influences development of nascent microbiota. Here we show that late-term California sea lion (Zalophus californianus) fetuses have true vernix caseosa, delivering BCFA and squalene to the fetal GI tract thereby recapitulating the human fetal gut microbial niche...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29745681/first-comparative-approach-to-touchscreen-based-visual-object-location-paired-associates-learning-in-humans-homo-sapiens-and-a-nonhuman-primate-microcebus-murinus
#11
Daniel Schmidtke, Sandra Ammersdörfer, Marine Joly, Elke Zimmermann
A recent study suggests that a specific, touchscreen-based task on visual object-location paired-associates learning (PAL), the so-called Different PAL (dPAL) task, allows effective translation from animal models to humans. Here, we adapted the task to a nonhuman primate (NHP), the gray mouse lemur, and provide first evidence for the successful comparative application of the task to humans and NHPs. Young human adults reach the learning criterion after considerably less sessions (one order of magnitude) than young, adult NHPs, which is likely due to faster and voluntary rejection of ineffective learning strategies in humans and almost immediate rule generalization...
May 10, 2018: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/29740057/mechanical-adaptation-of-trabecular-bone-morphology-in-the-mammalian-mandible
#12
Peter J Watson, Laura C Fitton, Carlo Meloro, Michael J Fagan, Flora Gröning
Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this structural support and is a major cause of tooth loss. However, the functional relationship between alveolar bone remodelling within the molar region and masticatory forces is not well understood. This study investigated this relationship by comparing mammalian species with different diets and functional loading (Felis catus, Cercocebus atys, Homo sapiens, Sus scrofa, Oryctolagus cuniculus, Ovis aries)...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29739020/how-do-transcatheter-heart-valves-fit-in-mitral-annuloplasty-rings-and-which-combination-can-be-recommended
#13
Roya Ostovar, Ralf-Uwe Kuehnel, Michael Erb, Martin Hartrumpf, Thomas Claus, Robert Haase, Johannes M Albes
BACKGROUND:  Transcatheter heart valve (THV) as valve-in-ring is increasingly used in the mitral position. Semi-rigid rings may serve as a more appropriate scaffold for proper anchoring of a THV as they may change from their oval to a round shape thereby fitting to the implanted THV. METHODS:  One rigid and five semi-rigid rings of four manufacturers, Edwards Physio I and II, Sorin 3D Memo, Medtronic Simulus, and St. Jude Medical (SJM) Saddle and SJM Sequin, with sizes 28 to 36 mm and Edwards Sapien III THV 23, 26, and 29 mm were used...
May 8, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29737552/competing-endogenous-rna-network-crosstalk-reveals-novel-molecular-markers-in-colorectal-cancer
#14
Nehal Samir, Marwa Matboli, Hanaa El-Tayeb, Ahmed El-Tawdi, Mohmed K Hassan, Sherif El-Khamisy, Hesham A E El-Akkad, Mohamed G Ramadan, Tarek N Al-Belkini, Farid El-Asmar
The competing endogenous RNA networks play a pivotal role in cancer diagnosis and progression. Novel properstrategies for early detection of colorectal cancer (CRC) are strongly needed. We investigated a novel CRC-specific RNA-based integrated competing endogenous network composed of lethal3 malignant brain tumor like1 (L3MBTL1) gene, long non-coding intergenic RNA- (lncRNA RP11-909B2.1) and homo sapiens microRNA-595 (hsa-miRNA-595) using in silico data analysis. RT-qPCR-based validation of the network was achieved in serum of 70 patients with CRC, 40 patients with benign colorectal neoplasm, and 20 healthy controls...
May 8, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29735900/synthesis-biological-evaluation-and-docking-studies-of-novel-bisquaternary-aldoxime-reactivators-on-acetylcholinesterase-and-butyrylcholinesterase-inhibited-by-paraoxon
#15
Kamil Kuca, Daniel Jun, Lucie Junova, Kamil Musilek, Martina Hrabinova, Jorge Alberto Valle da Silva, Teodorico Castro Ramalho, Marian Valko, Qinghua Wu, Eugenie Nepovimova, Tanos Celmar Costa França
Nerve agents and oxon forms of organophosphorus pesticides act as strong irreversible inhibitors of two cholinesterases in the human body: acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BChE; EC 3.1.1.8), and are therefore highly toxic compounds. For the recovery of inhibited AChE, antidotes from the group of pyridinium or bispyridinium aldoxime reactivators (pralidoxime, obidoxime, HI-6) are used in combination with anticholinergics and anticonvulsives. Therapeutic efficacy of reactivators (called “oximes”) depends on their chemical structure and also the type of organophosphorus inhibitor...
May 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29735829/nonspecific-amplification-of-human-dna-by-streptococcus-pneumoniae-lyta-primer
#16
Helen Hencida Thangamony, Ravindran Kumar, Chinnappan Palaniappan Thangavelu, Mani Mariappa, Berlin Grace Viswanathan Mariammal, Kootallur Narayanan Brahmadathan
Background: Determination of various analytical parameters is essential for the validation of primers used for in-house nucleic acid amplification tests. While standardising a high-resolution melt analysis (HRMA) for detection of Streptococcus pneumoniae in acute pyogenic meningitis, we encountered non-specific amplification of certain base pair sequences of human DNA by Centers for Disease Control & Prevention, USA recommended S. pneumoniae LytA primer. Materials and Methods: HRMA was standardised using DNA extracted from an ATCC strain of S...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29728786/spatial-representation-of-magnitude-in-humans-homo-sapiens-western-lowland-gorillas-gorilla-gorilla-gorilla-and-american-black-bears-ursus-americanus
#17
Zoe Johnson-Ulrich, Jennifer Vonk
The spatial-numerical association of response codes (SNARC) effect is the tendency for humans to respond faster to relatively larger numbers on the left or right (or with the left or right hand) and faster to relatively smaller numbers on the other side. This effect seems to occur due to a spatial representation of magnitude either in occurrence with a number line (wherein participants respond to relatively larger numbers faster on the right), other representations such as clock faces (responses are reversed from number lines), or culturally specific reading directions, begging the question as to whether the effect may be limited to humans...
May 4, 2018: Animal Cognition
https://www.readbyqxmd.com/read/29727052/bacteria-in-the-ageing-gut-did-the-taming-of-fire-promote-a-long-human-lifespan
#18
EDITORIAL
Antoine Danchin
Unique among animals as they evolved towards Homo sapiens, hominins progressively cooked their food on a routine basis. Cooked products are characterised by singular chemical compounds, derived from the pervasive Maillard reaction. This same reaction is omnipresent in normal metabolism involving carbonyls and amines, and its products accumulate with age. The gut microbiota acts as a first line of defence against the toxicity of cooked Maillard compounds, that also selectively shape the microbial flora, letting specific metabolites to reach the blood stream...
May 4, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29726601/comparison-of-paravalvular-aortic-leak-characteristics-in-the-medtronic-corevalve-versus-edwards-sapien-valve-paravalvular-aortic-leak-characteristics
#19
Olivia N Gilbert, Charles H Choi, Jodie L Franzil, Melissa Caughey, Waqas Qureshi, R Brandon Stacey, Min Pu, Robert J Applegate, Sanjay K Gandhi, David X M Zhao
OBJECTIVES: Temporally quantify and localize paravalvular aortic leak (PVL) after transcatheter aortic valve replacement (TAVR) in the Medtronic CoreValve (MCV) versus the Edwards Sapien Valve (ESV). BACKGROUND: In order to increase the precision of THV selection and PVL intervention, an understanding of PVL characteristics is essential. METHODS: The frequency, severity, and location of post-TAVR PVL were evaluated with transthoracic echocardiography pre-discharge, one month, and one-year post-procedure in 202 patients receiving a MCV (N = 120) or ESV (N = 81)...
May 4, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29723629/oil-from-the-fruits-of-pterodon-emarginatus-vog-a-traditional-anti-inflammatory-study-combining-in-vivo-and-in-silico
#20
Cleydson Breno Rodrigues Dos Santos, Ryan da Silva Ramos, Brenda Lorena Sánchez Ortiz, Gabriel Monteiro da Silva, Silvana Giuliatti, José Luis Balderas-Lopez, Andrés Navarrete, José Carlos Tavares Carvalho
ETHNOBOTANICAL RELEVANCE: The oil obtained from the fruits of Pterodon emarginatus Vog. (OPe) is used orally and topically, in traditional medicine for some purposes, such as acute and chronic inflammatory states as rheumatoid arthritis. MATERIALS AND METHODS: In this work, the anti-inflammatory activity of the OPe was demonstrated based on several animal models and presented an in silico study based on the 6α,7β-dihydroxy-vouacapan-17β-oic acid (DHVA) majority compound of the OPe to evaluate the interaction this compound, with cyclooxygenase-2 (COX-2) in 4COX (Mus musculus) and 5KIR (Homo sapiens) and molecular dynamics simulation...
April 30, 2018: Journal of Ethnopharmacology
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