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https://www.readbyqxmd.com/read/27891602/cannabimimetic-phytochemicals-in-the-diet-an-evolutionary-link-to-food-selection-and-metabolic-stress-adaptation
#1
REVIEW
Jürg Gertsch
The endocannabinoid system (ECS) is a major lipid signaling network that plays important pro-homeostatic (allostatic) roles not only in the nervous system but in peripheral organs. Increasing evidence points towards a dietary component in the modulation of the ECS. Cannabinoid receptors in hominids co-evolved with diet and the ECS constitutes a feedback loop for food selection and energy metabolism. Here it is postulated that the mismatch of ancient lipid genes of hunter-gatheres and pastoralists with the high carbohydrate diet introduced by agriculture could be compensated via dietary modulation of the ECS...
November 27, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27876694/hypersuccinylacetonaemia-and-normal-liver-function-in-maleylacetoacetate-isomerase-deficiency
#2
Hao Yang, Walla Al-Hertani, Denis Cyr, Rachel Laframboise, Guy Parizeault, Shu Pei Wang, Francis Rossignol, Marie-Thérèse Berthier, Yves Giguère, Paula J Waters, Grant A Mitchell
BACKGROUND: A high level of succinylacetone (SA) in blood is a sensitive, specific newborn screening marker for hepatorenal tyrosinemia type 1 (HT1, MIM 276700) caused by deficiency of fumarylacetoacetate hydrolase (FAH). Newborns with HT1 are usually clinically asymptomatic but show liver dysfunction with coagulation abnormalities (prolonged prothrombin time and/or high international normalised ratio). Early treatment with nitisinone (NTBC) plus dietary restriction of tyrosine and phenylalanine prevents the complications of severe liver disease and neurological crises...
November 22, 2016: Journal of Medical Genetics
https://www.readbyqxmd.com/read/27876501/serum-and-urinary-biomarkers-that-predict-hepatorenal-syndrome-in-patients-with-advanced-cirrhosis
#3
Desmond Y H Yap, Wai Kay Seto, James Fung, Siu Ho Chok, See Ching Chan, Gary C W Chan, Man Fung Yuen, Tak Mao Chan
BACKGROUND: Prediction of hepatorenal syndrome (HRS) remains difficult in advanced cirrhotic patients. AIMS: To evaluate use of serum and urine biomarkers to predict HRS. METHODS: We prospectively recruited Child's B or C cirrhotic patients with normal serum creatinine, and followed them for 12 weeks for the development of HRS. Serum Cystatin C (CysC), serum and urine Neutrophil Gelatinase-Associated Lipocalin (NGAL), serum and urine IL-18, serum N-acetyl-β-d glucosaminidase (NAG), urine kidney injury molecule-1 (KIM-1) and urine liver-type fatty acid binding protein (LFABP) were measured at recruitment (baseline), and their relationship with subsequent HRS investigated...
November 10, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27871159/-acute-kidney-injury-in-cirrhotic-patients-with-portal-hypertension
#4
REVIEW
So Mi Kim, Il Han Song
Acute kidney injury (AKI) is one of the most common manifestations encountered in clinical practice. It is associated with high morbidity and mortality in cirrhotic pre- and post-transplantation patients. Hepatorenal syndrome (HRS), a special form of AKI in cirrhotic patients, was recognized as a consequence of renal vasoconstriction from systemic/renal hemodynamic alterations developed in advanced cirrhosis with portal hypertension. Recently, multiple factors-such as infection/inflammation, underlying glomerulonephritis, bile cast, or increased abdominal pressure-have been considered to contribute to renal dysfunction in cirrhotic patients, which were presumed to induce HRS...
November 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/27867167/evaluation-of-fat-quantification-in-the-liver-using-dual-energy-ct
#5
Shunsuke Itaya, Takeshi Matsui, Tetsuya Kamiyama, Hiroyuki Yoshino
BACKGROUND AND PURPOSE: Recently, the number of patients with nonalcoholic fatty liver disease (NAFLD) has been increasing, and some of them progresses to cirrhosis and hepatocellular carcinoma. Dual energy CT allows the discrimination of substance using monochromatic image (MI), and steatosis exhibit specifically the CT value of each energy level. The purpose is to evaluate the fat quantification in the liver using spectral HU curve and CT value compare to a conventional image diagnosis...
2016: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/27865795/hepatic-angiomyolipomas-may-overexpress-tfe3-but-have-no-relevant-genetic-alterations
#6
Naoe Jimbo, Takashi Nishigami, Masayuki Noguchi, Hiroko Iijima, Seiichi Hirota, Takuma Tajiri, Takeshi Inoue, Takanori Hirose, Tomoo Itoh, Yoh Zen
The fusion or amplification of TFE3 has been identified as one of the molecular events underlying tumorigenesis in perivascular epithelioid cell tumors (PEComas). TFE3 rearrangements in PEComas are related to the morphological features of the epithelioid appearance and weaker expression of immunohistochemical muscular markers. This study aimed to clarify whether these genetic alterations are involved in hepatic angiomyolipomas (AMLs), which are a member of the PEComa tumor family. We examined 28 liver specimens (15 biopsies and 13 surgical specimens) of hepatic AMLs obtained from 26 patients...
November 16, 2016: Human Pathology
https://www.readbyqxmd.com/read/27850217/577-impact-of-hepatorenal-syndrome-reversal-on-clinical-outcomes-beyond-survival
#7
Khurram Jamil, Ram Subramanian, Stephen Pappas, Stevan Gonzalez, Shannon Escalante
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27847526/natural-products-improving-hyperuricemia-with-hepatorenal-dual-effects
#8
REVIEW
Shijun Hao, Chunlei Zhang, Haiyan Song
This review aims to put forth an overview of natural products reducing uric acid level with hepatorenal dual effects. The prevalence of hyperuricemia increased rapidly in recent years and has closely interdependent relationship with other metabolic disorders. Current therapeutically used drugs including a few uricostatic and uricosuric chemical drugs are proved efficient to control serum uric acid level. However, their side effects as well as contraindication in some cases with liver, kidney injury, or other conditions frequently limit their clinic application...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27843430/cirrhotic-cardiomyopathy-another-case-of-a-successful-approach-to-treatment-of-hepatorenal-syndrome
#9
Luis Otávio Mocarzel, Jessica Bicca, Luiza Jarske, Thamires Oliveira, Pedro Lanzieri, Ronaldo Gismondi, Mario Luiz Ribeiro
Hepatorenal syndrome (HRS) is defined as a failure of renal function, potentially reversible, in patients with liver cirrhosis and ascites. Recently, a component of cardiomyopathy associated with HRS was described, but the use of positive inotropic medicine as part of the treatment of the acute phase has not been extensively evaluated. We report a second case in our hospital of a patient with HRS type I without previous heart disease, with secondary hemodynamic decompensation due to liver disease, in which the abnormalities in systolic function by speckle-tracking echocardiography were observed and could be reversed by the use of inotropes...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27813334/the-model-for-end-stage-liver-disease-score-in%C3%A2-acute-heart-failure-hepatorenal-dysfunction-hides-behind
#10
EDITORIAL
John Parissis, Maria Nikolaou, Alexandre Mebazaa
No abstract text is available yet for this article.
December 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27801493/hyponatremia-in-cirrhosis-risk-factors-and-prognostic-value
#11
Rym Ennaifer, Myriam Cheikh, Hayfa Romdhane, Rafika El Elj, Houda Ben Nejma, Wassila Bougassas, Najet Bel Hadj
Background Hyponatremia is the most common electrolyte abnormality encountered in cirrhotic patients. Recent studies have shown that hyponatremia was correlated with severity of cirrhosis and associated with increased risk of complications and mortality. However this relationship is still unclear. The aims of the present study were to search predictive factors for hyponatremia in cirrhosis and to assess its prognostic value. Methods We performed a retrospective study, including consecutive cirrhotic patients admitted to our department between January 2011 and April 2014...
May 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/27788560/increased-brain-cortical-thickness-associated-with-visceral-fat-in-adolescents
#12
R L Saute, R B Soder, J O Alves Filho, M Baldisserotto, A R Franco
BACKGROUND: There has been a growing amount of evidence indicating that excess visceral fat is associated with alterations in brain structure and function, including brain cortical thinning in adults. OBJECTIVES: This study aims to investigate the relationship between brain cortical thickness with obesity assessments, in adolescents. METHODS: In this study, we measured three different obesity assessments within an adolescent population (aged 15 - 18 years): body mass index (BMI), visceral fat ratio measured with an MRI and hepatorenal gradient measured with an ultrasound...
October 27, 2016: Pediatric Obesity
https://www.readbyqxmd.com/read/27784430/-prognostic-value-of-a-logistic-regression-model-based-on-keratin-18-in-patients-with-hbv-related-liver-failure
#13
Q R Gan, X Y Jiang, X Zhang, M S Chen, C Pan
Objective: To investigate the association between serum keratin 18 (K18) level and prognosis in patients with HBV-related acute-on-chronic liver failure (ACLF). Methods: A total of 120 patients who visited Department of Hepatology in Fuzhou Infectious Disease Hospital and were diagnosed with HBV-related ACLF from December 2012 to March 2014 were enrolled and followed up for 3 months. The patients were divided into death group and survival group. The serum levels of K18 fragments (M30 and M65) were measured and related laboratory data were collected to analyze the differences in M30, M65, M30/M65, and other laboratory markers...
July 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/27784429/-clinical-features-of-liver-cirrhosis-complicated-by-portal-vein-thrombosis-and-related-risk-factors
#14
G S Lin, Q Xu, S Y Zhao, Y X Zhang
Objective: To investigate the clinical features of patients with liver cirrhosis complicated by portal vein thrombosis (PVT) and related risk factors. Methods: A total of 65 patients with liver cirrhosis complicated by PVT who were diagnosed and treated from June 2013 to June 2015 were enrolled as PVT group, and 70 cirrhotic patients without PVT were enrolled as controls (non-PVT group). The data collected included general information, results of laboratory examination, imaging findings, clinical manifestations, and complications...
July 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/27780576/bile-cast-nephropathy-caused-by-obstructive-cholestasis
#15
Julien Aniort, Anaïs Poyet, Jean-Louis Kemeny, Carole Philipponnet, Anne-Elisabeth Heng
Acute kidney injury (AKI) is a major complication in patients with liver disease. Although hepatorenal syndrome is frequently involved, bile cast nephropathy, characterized by tubular bile cast formation, has been scarcely described in the setting of severe liver failure. Few renal histology studies are available in these patients. We describe a case of bile cast nephropathy in a patient with obstructive cholestasis caused by stones in the common bile duct. The kidney biopsy confirmed this diagnosis, with several green casts in tubular lumens, tubular injury, and bilirubin composition of the tubular casts with Hall stain...
October 22, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27763922/why-are-patients-still-getting-and-dying-from-acute-kidney-injury
#16
John A Kellum
PURPOSE OF REVIEW: Acute kidney injury is common and is associated with increased morbidity and mortality. Rates of acute kidney injury in most settings remain high and in some settings are increasing. Moreover, outcomes associated with acute kidney injury remain relatively poor. This review focuses on recent advances in understanding of acute kidney injury and discusses possible interventions based on these advances. RECENT FINDINGS: Acute kidney injury is not a disease with a single etiology and clinical course but rather a loose collection of syndromes whose unifying phenotype is an acute loss of glomerular filtration...
December 2016: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/27762512/noradrenaline-is-as-effective-as-terlipressin-in-hepatorenal-syndrome-type-1-a-prospective-randomized-trial
#17
Omesh Goyal, Sandeep Singh Sidhu, Natasha Sehgal, Sandeep Puri
OBJECTIVES: Hepatorenal syndrome (HRS) is a functional renal failure occurring in end stage liver disease, which is associated with poor prognosis. Terlipressin has been shown to be effective in treatment of HRS. More recently, it was suggested that noradrenaline, an alpha-adrenergic drug may be also effective in HRS. We aimed to compare the efficacy of noradrenaline versus terlipressin in treatment of HRS type 1. METHODS: Consecutive patients with cirrhosis and HRS type 1 were enrolled and randomised into 2 groups- Group A received intravenous noradrenaline infusion (0...
September 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27747278/efficacy-of-argon-plasma-coagulation-in-the-management-of-portal-hypertensive-gastropathy
#18
Amr Shaaban Hanafy, Amr Talaat El Hawary
Objectives: Evaluation of the outcome and experience in 2 years of management of portal hypertensive gastropathy (PHG) by argon plasma coagulation (APC) in a cohort of Egyptian cirrhotic patients. Methods: This study was conducted over a 2-year period from January 2011 to February 2013. Upper gastrointestinal endoscopy was performed to evaluate the degree and site of PHG. APC was applied to areas with mucosal vascular lesions. Results: In total, 200 cirrhotic patients were enrolled; 12 patients were excluded due to death (n = 6) caused by hepatic encephalopathy (n = 3), hepatorenal syndrome (n = 2), or chronic lymphatic leukemia (n = 1), or did not complete the treatment sessions (n = 6), so 188 patients completed the study...
October 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27727684/acute-kidney-injury-in-cirrhosis-besides-hepatorenal-syndrome
#19
Niranjan Gogoi, Sangitanjan Dutta, Chiranjita Phukan
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27721921/is-meld-score-failing-patients-with-liver-disease-and-hepatorenal-syndrome
#20
Lena Sibulesky, Nicolae Leca, Christopher Blosser, Amir A Rahnemai-Azar, Renuka Bhattacharya, Jorge Reyes
There is a need to reassess the application of MELD and the impact of renal insufficiency with consideration for developing an algorithm with exception points that would lead to timely allocation of livers to patients with hepatorenal syndrome prior to occurrence of permanent renal damage without jeopardizing post-transplant survival.
September 28, 2016: World Journal of Hepatology
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