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https://www.readbyqxmd.com/read/29355928/physician-market-structure-patient-outcomes-and-spending-an-examination-of-medicare-beneficiaries
#1
Thomas Koch, Brett Wendling, Nathan E Wilson
OBJECTIVE: To understand the impact of changes in physician market structure on clinical outcomes and health care utilization. DATA SOURCES: 2005-2012 Medicare fee-for-service claims and enrollment data. STUDY DESIGN: We consider the effect of cardiology market structure on utilization and health outcomes for four patient populations. We estimate the risk-adjusted impact of competition using multivariate regression models. PRINCIPAL FINDINGS: The study finds that an increase in consolidation leads to statistically and economically significant increases in negative health outcomes...
January 22, 2018: Health Services Research
https://www.readbyqxmd.com/read/29350592/geographic-proximity-to-specialized-pediatric-neurosurgical-care-in-the-contiguous-united-states
#2
Abdul-Kareem Ahmed, Ann-Christine Duhaime, Timothy R Smith
OBJECTIVE Absent from an analysis of supply is consideration of the geographic distribution of pediatric neurosurgeons. Several patient socioeconomic metrics are known to be associated with outcome in pediatric neurosurgical diseases, such as hydrocephalus. The purpose of this study was to determine current geographic proximity to pediatric neurosurgical care using professional society databases. This study also sought to establish how socioeconomic factors are related to distance to care, using federal government-collected data...
January 19, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29342185/nanocarrier-mediated-foliar-zinc-fertilization-influences-expression-of-metal-homeostasis-related-genes-in-flag-leaves-and-enhances-gluten-content-in-durum-wheat
#3
Paresh Deshpande, Ashwin Dapkekar, Manoj Oak, Kishore Paknikar, Jyutika Rajwade
BACKGROUND: Wheat is the staple food for most of the world's population; however, it is a poor source of zinc. Foliar fertilization of zinc via zinc loaded chitosan nanocarriers (Zn-CNP) post-anthesis has proved to be a promising approach for grain zinc enhancement in durum wheat as evidenced in our earlier study. However, the molecular mechanism of uptake of zinc via Zn-CNP remains unclear. METHODS/PRINCIPLE FINDINGS: Foliar application of Zn-CNP was performed at post anthesis stages in two durum wheat cultivars (MACS 3125 and UC1114, containing the Gpc-B1 gene), and expression levels of several metal-related genes were analyzed during early senescence...
2018: PloS One
https://www.readbyqxmd.com/read/29342135/structures-of-%C3%AE-klotho-reveal-a-zip-code-like-mechanism-for-endocrine-fgf-signalling
#4
Sangwon Lee, Jungyuen Choi, Jyotidarsini Mohanty, Leiliane P Sousa, Francisco Tome, Els Pardon, Jan Steyaert, Mark A Lemmon, Irit Lax, Joseph Schlessinger
Canonical fibroblast growth factors (FGFs) activate FGF receptors (FGFRs) through paracrine or autocrine mechanisms in a process that requires cooperation with heparan sulfate proteoglycans, which function as co-receptors for FGFR activation. By contrast, endocrine FGFs (FGF19, FGF21 and FGF23) are circulating hormones that regulate critical metabolic processes in a variety of tissues. FGF19 regulates bile acid synthesis and lipogenesis, whereas FGF21 stimulates insulin sensitivity, energy expenditure and weight loss...
January 17, 2018: Nature
https://www.readbyqxmd.com/read/29336799/access-to-high-pediatric-readiness-emergency-care-in-the-united-states
#5
Kristin N Ray, Lenora M Olson, Elizabeth A Edgerton, Michael Ely, Marianne Gausche-Hill, Patricia Schmuhl, David J Wallace, Jeremy M Kahn
OBJECTIVE: To determine the geographic accessibility of emergency departments (EDs) with high pediatric readiness by assessing the percentage of US children living within a 30-minute drive time of an ED with high pediatric readiness, as defined by collaboratively developed published guidelines. STUDY DESIGN: In this cross-sectional analysis, we examined geographic access to an ED with high pediatric readiness among US children. Pediatric readiness was assessed using the weighted pediatric readiness score (WPRS) of US hospitals based on the 2013 National Pediatric Readiness Project (NPRP) survey...
January 12, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29336697/understanding-knowledge-attitudes-and-behaviors-toward-west-nile-virus-prevention-a-survey-of-high-risk-adults-in-maryland
#6
Kimberly C Mitchell, Patricia Ryan, Donna E Howard, Katherine A Feldman
OBJECTIVE: To assess knowledge, attitudes, and behaviors toward West Nile virus (WNV) prevention among Maryland adults ≥60 years old who are at increased risk of severe WNV disease utilizing the health belief model. METHODS: Using a stratified random sample of households from zip codes with ≥2 human WNV cases, we conducted a telephone survey of 211 Maryland adults ≥60 years old between October and December 2012. RESULTS: Participants expressing worry about WNV were over thrice more likely to use insect repellent in the prior 90 days (adjusted odds ratio [aOR] = 3...
January 16, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29335856/abscopal-effects-of-radiotherapy-and-combined-mrna-based-immunotherapy-in-a-syngeneic-ova-expressing-thymoma-mouse-model
#7
Lucas Basler, Aleksandra Kowalczyk, Regina Heidenreich, Mariola Fotin-Mleczek, Savas Tsitsekidis, Daniel Zips, Franziska Eckert, Stephan M Huber
BACKGROUND: Tumor metastasis and immune evasion present major challenges of cancer treatment. Radiotherapy can overcome immunosuppressive tumor microenvironments. Anecdotal reports suggest abscopal anti-tumor immune responses. This study assesses abscopal effects of radiotherapy in combination with mRNA-based cancer vaccination (RNActive®). METHODS: C57BL/6 mice were injected with ovalbumin-expressing thymoma cells into the right hind leg (primary tumor) and left flank (secondary tumor) with a delay of 4 days...
January 16, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29335255/neighbourhood-looking-glass-360%C3%A2%C2%BA-automated-characterisation-of-the-built-environment-for-neighbourhood-effects-research
#8
Quynh C Nguyen, Mehdi Sajjadi, Matt McCullough, Minh Pham, Thu T Nguyen, Weijun Yu, Hsien-Wen Meng, Ming Wen, Feifei Li, Ken R Smith, Kim Brunisholz, Tolga Tasdizen
BACKGROUND: Neighbourhood quality has been connected with an array of health issues, but neighbourhood research has been limited by the lack of methods to characterise large geographical areas. This study uses innovative computer vision methods and a new big data source of street view images to automatically characterise neighbourhood built environments. METHODS: A total of 430 000 images were obtained using Google's Street View Image API for Salt Lake City, Chicago and Charleston...
January 15, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29330260/race-and-socioeconomic-status-independently-affect-risk-of-major-amputation-in-peripheral-artery-disease
#9
Shipra Arya, Zachary Binney, Anjali Khakharia, Luke P Brewster, Phil Goodney, Rachel Patzer, Jason Hockenberry, Peter W F Wilson
BACKGROUND: Black race has been shown to be a risk factor for amputation in peripheral artery disease (PAD); however, race has been argued to be a marker for socioeconomic status (SES) rather than true disparity. The aim of this study is to study the impact of race and SES on amputation risk in PAD patients. METHODS AND RESULTS: Patients with incident PAD in the national Veterans Affairs Corporate Data Warehouse were identified from 2003 to 2014 (N=155 647). The exposures were race and SES (measured by median income in residential ZIP codes)...
January 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29322555/evaluating-factors-impacting-medication-adherence-among-rural-urban-and-suburban-populations
#10
Cody Arbuckle, Daniel Tomaszewski, Benjamin D Aronson, Lawrence Brown, Jon Schommer, Donald Morisky, Erik Linstead
PURPOSE: To evaluate differences in prescription medication adherence rates, as well as influencing factors, in rural and urban adults. METHODS: This is a retrospective analysis of the 2015 National Consumer Survey on the Medication Experience and Pharmacists' Role. A total of 26,173 participants completed the survey and provided usable data. Participants using between 1 and 30 prescription medications and living more than 0 miles and up to 200 miles from their nearest pharmacy were selected for the study, resulting in a total of 15,933 participants...
January 10, 2018: Journal of Rural Health
https://www.readbyqxmd.com/read/29321307/kaposi-s-sarcoma-associated-herpesvirus-k8-is-an-rna-binding-protein-that-regulates-viral-dna-replication-in-coordination-with-a-noncoding-rna
#11
Dongcheng Liu, Yan Wang, Yan Yuan
KSHV lytic replication and constant primary infection of fresh cells are crucial for viral tumorigenicity. Virus-encoded b-Zip family protein K8 plays an important role in viral DNA replication in both viral reactivation and de novo infection. The mechanism underlying the functional role of K8 in the viral life cycle is elusive. Here we report that K8 is a RNA binding protein, which also associates with many proteins including other RNA binding proteins. Many K8-involved protein-protein interactions are mediated by RNA...
January 10, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29306919/zero-inflated-conway-maxwell-poisson-distribution-to-analyze-discrete-data
#12
Shin Zhu Sim, Ramesh C Gupta, Seng Huat Ong
In this paper, we study the zero-inflated Conway-Maxwell Poisson (ZICMP) distribution and develop a regression model. Score and likelihood ratio tests are also implemented for testing the inflation/deflation parameter. Simulation studies are carried out to examine the performance of these tests. A data example is presented to illustrate the concepts. In this example, the proposed model is compared to the well-known zero-inflated Poisson (ZIP) and the zero- inflated generalized Poisson (ZIGP) regression models...
January 9, 2018: International Journal of Biostatistics
https://www.readbyqxmd.com/read/29301596/study-of-zero-inflated-regression-models-in-a-large-scale-population-survey-of-sub-health-status-and-its-influencing-factors
#13
Tao Xu, Guang-Jin Zhu, Shao-Mei Han
Objective Sub-health status has progressively gained more attention from both medical professionals and the publics. Treating the number of sub-health symptoms as count data rather than dichotomous data helps to completely and accurately analyze findings in sub-healthy population. This study aims to compare the goodness of fit for count outcome models to identify the optimum model for sub-health study. Methods The sample of the study derived from a large-scale population survey on physiological and psychological constants from 2007 to 2011 in 4 provinces and 2 autonomous regions in China...
December 30, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/29301546/spatial-and-temporal-patterns-of-dengue-infections-in-timor-leste-2005-2013
#14
Kinley Wangdi, Archie C A Clements, Tai Du, Susana Vaz Nery
BACKGROUND: Dengue remains an important public health problem in Timor-Leste, with several major epidemics occurring over the last 10 years. The aim of this study was to identify dengue clusters at high geographical resolution and to determine the association between local environmental characteristics and the distribution and transmission of the disease. METHODS: Notifications of dengue cases that occurred from January 2005 to December 2013 were obtained from the Ministry of Health, Timor-Leste...
January 4, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29298797/development-and-validation-of-a-gene-signature-for-patients-with-head-and-neck-squamous-cell-carcinomas-treated-by-postoperative-radio-chemo-therapy
#15
Stefan Schmidt, Annett Linge, Alex Zwanenburg, Stefan Leger, Fabian Lohaus, Constanze Krenn, Steffen Appold, Volker Gudziol, Alexander Nowak, Clare von Neubeck, Ingeborg Tinhofer, Volker Budach, Ali Sak, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Hatice Bunea, Anca Ligia Grosu, Amir Abdollahi, Juergen Debus, Ute Ganswindt, Claus Belka, Steffi U Pigorsch, Stephanie Elisabeth Combs, David Mönnich, Daniel Zips, Gustavo B Baretton, Frank Buchholz, Michael Baumann, Mechthild Krause, Steffen Löck
PURPOSE: The aim of this study was to identify and independently validate a novel gene signature predicting loco-regional tumor control (LRC) for treatment individualization of patients with locally advanced HPV-negative head and neck squamous cell carcinomas (HNSCC) who are treated with postoperative radio(chemo)therapy (PORT-C). EXPERIMENTAL DESIGN: Gene expression analyses were performed using nanoString technology on a multicenter training cohort of 130 patients and an independent validation cohort of 121 patients...
January 3, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29296905/sociodemographic-factors-in-patients-continuing-warfarin-vs-those-transitioning-to-direct-oral-anticoagulants
#16
Jordan K Schaefer, Suman L Sood, Brian Haymart, Xiaokui Gu, Xiaowen Kong, Eva Kline-Rogers, Steven Almany, Jay Kozlowski, Gregory D Krol, Scott Kaatz, James B Froehlich, Geoffrey D Barnes
Clinical factors and patient preferences are important for selecting oral anticoagulants for venous thromboembolism (VTE) and atrial fibrillation (AF). The relative association of sociodemographic factors with anticoagulant use is unknown. We evaluated a prospective cohort to compare sociodemographic variables in patients who continued on warfarin for AF or VTE to those who transitioned to 1 of the direct oral anticoagulants (DOACs). Adult patients, newly started on warfarin, were enrolled through 6 anticoagulation clinics across Michigan...
December 12, 2017: Blood Advances
https://www.readbyqxmd.com/read/29295747/comparison-of-detection-methods-for-hpv-status-as-a-prognostic-marker-for-loco-regional-control-after-radiochemotherapy-in-patients-with-hnscc
#17
Annett Linge, Ulrike Schötz, Steffen Löck, Fabian Lohaus, Cläre von Neubeck, Volker Gudziol, Alexander Nowak, Inge Tinhofer, Volker Budach, Ali Sak, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Hatice Bunea, Anca-Ligia Grosu, Amir Abdollahi, Jürgen Debus, Ute Ganswindt, Kirsten Lauber, Steffi Pigorsch, Stephanie E Combs, David Mönnich, Daniel Zips, Gustavo B Baretton, Frank Buchholz, Mechthild Krause, Claus Belka, Michael Baumann
OBJECTIVE: To compare six HPV detection methods in pre-treatment FFPE tumour samples from patients with locally advanced head and neck squamous cell carcinoma (HNSCC) who received postoperative (N = 175) or primary (N = 90) radiochemotherapy. MATERIALS AND METHODS: HPV analyses included detection of (i) HPV16 E6/E7 RNA, (ii) HPV16 DNA (PCR-based arrays, A-PCR), (iii) HPV DNA (GP5+/GP6+ qPCR, (GP-PCR)), (iv) p16 (immunohistochemistry, p16 IHC), (v) combining p16 IHC and the A-PCR result and (vi) combining p16 IHC and the GP-PCR result...
December 30, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29290514/living-in-lower-income-zip-codes-is-associated-with-more-severe-chronic-rhinosinusitis
#18
Christopher D Codispoti, David E Tapke, Phillip S LoSavio, Pete S Batra, Mahboobeh Mahdavinia
No abstract text is available yet for this article.
December 28, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29290403/zipping-and-unzipping-protein-modifications-regulating-synaptonemal-complex-dynamics
#19
REVIEW
Jinmin Gao, Monica P Colaiácovo
The proteinaceous zipper-like structure known as the synaptonemal complex (SC), which forms between pairs of homologous chromosomes during meiosis from yeast to humans, plays important roles in promoting interhomolog crossover formation, regulating cessation of DNA double-strand break (DSB) formation following crossover designation, and ensuring accurate meiotic chromosome segregation. Recent studies are starting to reveal critical roles for different protein modifications in regulating SC dynamics. Protein SUMOylation, N-terminal acetylation, and phosphorylation have been shown to be essential for the regulated assembly and disassembly of the SC...
December 28, 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/29290019/trends-in-racial-and-ethnic-disparities-in-childhood-asthma-in-miami-florida-2005-2013
#20
Consuelo M Beck-Sague, Alejandro Arrieta, M Claudia Pinzon-Iregui, Benjamin Ortiz, Andrew G Dean, Andrew Cuddihy, Janvier Gasana
Nationally, racial and ethnic disparities in childhood asthma plateaued from 2005 to 2013. We assessed trends in childhood asthma in Miami, Florida using Youth Risk Behavior Surveillance System (YRBSS) data and emergency department (ED) utilization and hospitalization rates by zip code population characteristics. Asthma prevalence in Miami did not vary significantly by race/ethnicity in YRBSS respondents in 2005 (16.2-17.2%, all groups), but rose in African-Americans and Hispanics and declined in Whites by 2013 to 27...
December 30, 2017: Journal of Immigrant and Minority Health
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