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https://www.readbyqxmd.com/read/28918547/adaptive-step-goals-and-rewards-a-longitudinal-growth-model-of-daily-steps-for-a-smartphone-based-walking-intervention
#1
Elizabeth V Korinek, Sayali S Phatak, Cesar A Martin, Mohammad T Freigoun, Daniel E Rivera, Marc A Adams, Pedja Klasnja, Matthew P Buman, Eric B Hekler
Adaptive interventions are an emerging class of behavioral interventions that allow for individualized tailoring of intervention components over time to a person's evolving needs. The purpose of this study was to evaluate an adaptive step goal + reward intervention, grounded in Social Cognitive Theory delivered via a smartphone application (Just Walk), using a mixed modeling approach. Participants (N = 20) were overweight (mean BMI = 33.8 ± 6.82 kg/m(2)), sedentary adults (90% female) interested in participating in a 14-week walking intervention...
September 16, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28918286/identifying-combinatorial-biomarkers-by-association-rule-mining-in-the-camd-alzheimer-s-database
#2
Balázs Szalkai, Vince K Grolmusz, Vince I Grolmusz
The concept of combinatorial biomarkers was conceived when it was noticed that simple biomarkers are often inadequate for recognizing and characterizing complex diseases. Here we present an algorithmic search method for complex biomarkers which may predict or indicate Alzheimer's disease (AD) and other kinds of dementia. We show that our method is universal since it can describe any Boolean function for biomarker discovery. We applied data mining techniques that are capable to uncover implication-like logical schemes with detailed quality scoring...
August 17, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28917951/a-spatial-analysis-of-race-local-health-promoting-resources-and-preventable-hospitalizations
#3
Caryn N Bell, Janice V Bowie, Roland J Thorpe, David M Levine
INTRODUCTION: Preventable hospitalizations (PHs) for chronic conditions could have been avoided if treated with primary healthcare. PH rates are higher among African Americans, and in areas with less healthcare. Little is known about the effects of non-healthcare local health-promoting resources (LHPRs). The objective of this study is to determine associations between LHPRs and chronic PH rates in Maryland, and to assess spatial clustering of areas with high PH rates. METHODS: Hospitalizations in 2010 were obtained from the Maryland Health Services Cost Review Commission by zip code of residence...
September 13, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28916294/characteristics-of-older-adults-in-primary-care-who-may-benefit-from-primary-palliative-care-in-the-united-states
#4
Nancy Dudley, Christine S Ritchie, Margaret I Wallhagen, Kenneth E Covinsky, Bruce A Cooper, Kanan Patel, Irena Stijacic-Cenzer, Susan A Chapman
CONTEXT: Older adults with advanced illness and associated symptoms may benefit from primary palliative care, but limited data exist to identify older adults in U.S. primary care to benefit from this care. OBJECTIVES: To describe U.S. primary care visits among adults 65 years and older with advanced illness. METHODS: Cross-sectional analysis of the National Ambulatory and Hospital Ambulatory Medical Care Surveys (2009-2011) was conducted using chi-square tests to compare visits without and with advanced illness to U...
September 12, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28912786/co-infection-of-sweet-orange-with-severe-and-mild-strains-of-citrus-tristeza-virus-is-overwhelmingly-dominated-by-the-severe-strain-on-both-the-transcriptional-and-biological-levels
#5
Shimin Fu, Jonathan Shao, Changyong Zhou, John S Hartung
Citrus tristeza is one of the most destructive citrus diseases and is caused by the phloem-restricted Closterovirus, Citrus tristeza virus. Mild strain CTV-B2 does not cause obvious symptoms on indicators whereas severe strain CTV-B6 causes symptoms, including stem pitting, cupping, yellowing, and stiffening of leaves, and vein corking. Our laboratory has previously characterized changes in transcription in sweet orange separately infected with CTV-B2 and CTV-B6. In the present study, transcriptome analysis of Citrus sinensis in response to double infection by CTV-B2 and CTV-B6 was carried out...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28905477/a-hd-zip-iii-gene-ptrhb4-is-required-for-interfascicular-cambium-development-in-populus
#6
Yingying Zhu, Dongliang Song, Peng Xu, Jiayan Sun, Laigeng Li
Wood production is dependent on the activity of the vascular cambium which develops from the fascicular and interfascicular cambium. However, little is known about the mechanisms controlling how the vascular cambium is developed in woody species. Here we show that PtrHB4, belonging to the Populus HD-ZIP III family, plays a critical role in the process of vascular cambium development. PtrHB4 was specifically expressed in shoot tip and stem vascular tissue at an early developmental stage. Repression of PtrHB4 caused defects in the development of the secondary vascular system due to failures in interfascicular cambium formation...
September 14, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28904075/association-between-living-in-food-deserts-and-cardiovascular-risk
#7
Heval M Kelli, Muhammad Hammadah, Hina Ahmed, Yi-An Ko, Matthew Topel, Ayman Samman-Tahhan, Mossab Awad, Keyur Patel, Kareem Mohammed, Laurence S Sperling, Priscilla Pemu, Viola Vaccarino, Tene Lewis, Herman Taylor, Greg Martin, Gary H Gibbons, Arshed A Quyyumi
BACKGROUND: Food deserts (FD), neighborhoods defined as low-income areas with low access to healthy food, are a public health concern. We evaluated the impact of living in FD on cardiovascular risk factors and subclinical cardiovascular disease (CVD) with the hypothesis that people living in FD will have an unfavorable CVD risk profile. We further assessed whether the impact of FD on these measures is driven by area income, individual household income, or area access to healthy food. METHODS AND RESULTS: We studied 1421 subjects residing in the Atlanta metropolitan area who participated in the META-Health study (Morehouse and Emory Team up to Eliminate Health Disparities; n=712) and the Predictive Health study (n=709)...
September 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28900506/combination-of-aav-trail-with-mir-221-zip-therapeutic-strategy-overcomes-the-resistance-to-trail-induced-apoptosis-in-liver-cancer
#8
Sisi Ma, Jiazeng Sun, Yabin Guo, Peng Zhang, Yanxin Liu, Dexian Zheng, Juan Shi
TNF-related apoptosis-inducing ligand (TRAIL) possesses the capacity to induce apoptosis in a wide variety of tumor cells without affecting most normal cells. However, it has now emerged that many primary cancer cells are resistant to TRAIL monotherapy. Overcoming the intrinsic or acquired TRAIL resistance is desirable for TRAIL-mediated cancer therapy. In this study, we found that the miR-221/222 cluster was up-regulated in TRAIL-resistant liver cancer cells. Specific inhibitors of miR-221 and/or miR-222, called sponge, TuD and miR-Zip were constructed, and their ability to overcome TRAIL resistance was compared...
2017: Theranostics
https://www.readbyqxmd.com/read/28899565/local-neighbors-as-positives-regional-neighbors-as-negatives-competing-channels-in-the-relationship-between-others-income-health-and-happiness
#9
John Ifcher, Homa Zarghamee, Carol Graham
That well-being is decreasing in others' income is termed the "relative income hypothesis" (RIH) by scholars of subjective well-being (SWB) and has substantial empirical support. Some studies, however, present evidence of both positive and negative explanatory channels in the relationship between others' income and SWB. We develop a theoretical framework integrating four distinct channels through which neighbors' income can affect utility: public goods, cost of living, expectations of future income, and direct effects (RIH or altruism)...
August 22, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/28893192/expression-of-the-zip-slc39a-transporters-in-%C3%AE-cells-a-systematic-review-and-integration-of-multiple-datasets
#10
Rebecca Lawson, Wolfgang Maret, Christer Hogstrand
BACKGROUND: Pancreatic β-cells require a constant supply of zinc to maintain normal insulin secretory function. Following co-exocytosis with insulin, zinc is replenished via the Zrt- and Irt-like (ZIP; SLC39A) family of transporters. However the ZIP paralogues of particular importance for zinc uptake, and associations with β-cell function and Type 2 Diabetes remain largely unexplored. We retrieved and statistically analysed publically available microarray and RNA-seq datasets to perform a systematic review on the expression of β-cell SLC39A paralogues...
September 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28892082/myofibril-contraction-and-crosslinking-drive-nuclear-movement-to-the-periphery-of-skeletal-muscle
#11
William Roman, João P Martins, Filomena A Carvalho, Raphael Voituriez, Jasmine V G Abella, Nuno C Santos, Bruno Cadot, Michael Way, Edgar R Gomes
Nuclear movements are important for multiple cellular functions, and are driven by polarized forces generated by motor proteins and the cytoskeleton. During skeletal myofibre formation or regeneration, nuclei move from the centre to the periphery of the myofibre for proper muscle function. Centrally located nuclei are also found in different muscle disorders. Using theoretical and experimental approaches, we demonstrate that nuclear movement to the periphery of myofibres is mediated by centripetal forces around the nucleus...
September 11, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28891398/geometric-analysis-of-loco-regional-recurrences-in-relation-to-pre-treatment-hypoxia-in-patients-with-head-and-neck-cancer
#12
Simon Boeke, Daniela Thorwarth, David Mönnich, Christina Pfannenberg, Gerald Reischl, Christian La Fougère, Konstantin Nikolaou, Paul-Stefan Mauz, Frank Paulsen, Daniel Zips, Stefan Welz
INTRODUCTION: A previous pattern-of-failure study has suggested that up to 50% of the loco-regional failures (LRF) in head and neck squamous cell carcinoma (HNSCC) occur outside the initial hypoxic volume determined by [(18)F]-fluoromisonidazole-PET ([(18)F]-FMISO-PET). The aim of the present analysis was to correlate spatial patterns of failure with respect to the pretherapeutic dynamic [(18)F]-FMISO-PET/CT in HNSCC after radiochemotherapy (RCT). MATERIAL AND METHODS: Within a running phase 2 trial using [(18)F]-FMISO-PET imaging prior to RCT in HNSCC patients (n = 54), we have observed so far 11 LRF with a minimum follow-up of 12 months...
September 11, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28881993/genomes-as-documents-of-evolutionary-history-a-probabilistic-macrosynteny-model-for-the-reconstruction-of-ancestral-genomes
#13
Yoichiro Nakatani, Aoife McLysaght
Motivation: It has been argued that whole-genome duplication (WGD) exerted a profound influence on the course of evolution. For the purpose of fully understanding the impact of WGD, several formal algorithms have been developed for reconstructing pre-WGD gene order in yeast and plant. However, to the best of our knowledge, those algorithms have never been successfully applied to WGD events in teleost and vertebrate, impeded by extensive gene shuffling and gene losses. Results: Here, we present a probabilistic model of macrosynteny (i...
July 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28878014/identification-of-a-35s-u4-u6-u5-tri-snrnp-complex-intermediate-in-spliceosome-assembly
#14
Zhe Chen, Bin Gui, Yu Zhang, Guojia Xie, Wanjin Li, Shumeng Liu, Bosen Xu, Chongyang Wu, Lin He, Jianguo Yang, Xia Yi, Xiaohan Yang, Luyang Sun, Jing Liang, Yongfeng Shang
The de novo assembly and post-splicing reassembly of the U4/U6.U5 tri-snRNP remain to be investigated. We report here that ZIP, a protein containing a CCCH type of zinc finger and a G-patch domain as we characterized previously, regulates pre-mRNA splicing in a RNA binding-independent manner. We found that ZIP is physically associated with the U4/U6.U5 tri-snRNP. Remarkably, ZIP-containing tri-snRNP has a sedimentation coefficient ~35S, a tri-snRNP that has not been described before. We showed that the 35S tri-snRNP contains hPrp24, indicative of a state when the U4/U6 di-snRNP is just integrating with the U5 snRNP...
September 6, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28875539/ago18b-negatively-regulates-determinacy-of-spikelet-meristems-on-the-tassel-central-spike-in-maize
#15
Wei Sun, Xiaoli Xiang, Lihong Zhai, Dan Zhang, Zheng Cao, Lei Liu, Zuxin Zhang
The maize tassel represents an indeterminate male inflorescence. The number of primordia that a given inflorescence meristem produces is related to its determinacy, i.e., capacity for continued meristem activity. Transcription factors (TFs) controlling determinacy in tassel axillary meristems are well studied in maize, and small RNAs are known to influence tassel development by repressing targets including tassel-related TFs. As core components of the RNA-inducible silence complex (RISC), Argonaute (AGO) proteins are required for small RNA-mediated repression...
September 6, 2017: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/28875161/crystal-structures-of-a-zip-zinc-transporter-reveal-a-binuclear-metal-center-in-the-transport-pathway
#16
Tuo Zhang, Jian Liu, Matthias Fellner, Chi Zhang, Dexin Sui, Jian Hu
Zrt/Irt-like proteins (ZIPs) play fundamental roles in metal metabolism/homeostasis and are broadly involved in numerous physiological and pathological processes. The lack of high-resolution structure of the ZIPs hinders understanding of the metal transport mechanism. We report two crystal structures of a prokaryotic ZIP in lipidic cubic phase with bound metal substrates (Cd(2+) at 2.7 Å and Zn(2+) at 2.4 Å). The structures revealed a novel 3+2+3TM architecture and an inward-open conformation occluded at the extracellular side...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28874944/using-geospatial-mapping-to-determine-the-impact-of-all-terrain-vehicle-crashes-on-both-rural-and-urban-communities
#17
Evelyn S Qin, Charles A Jennissen, Caroline A Wadman, Gerene M Denning
INTRODUCTION: Deaths and injuries from all-terrain vehicle (ATV) crashes result in approximately 700 deaths each year and more than 100,000 emergency department (ED) visits. Common misconceptions about ATV crashes are a significant barrier to injury prevention efforts, as is the lack of key information about where and how crashes occur. The purpose of this study was to determine ATV crash patterns within a state, and to compare and contrast characteristics of these crashes as a function of crash-site rurality...
August 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28874932/emergency-department-use-across-88-small-areas-after-affordable-care-act-implementation-in-illinois
#18
Joe Feinglass, Andrew J Cooper, Kelsey Rydland, Emilie S Powell, Megan McHugh, Raymond Kang, Scott M Dresden
INTRODUCTION: This study analyzes changes in hospital emergency department (ED) visit rates before and after the 2014 Affordable Care Act (ACA) insurance expansions in Illinois. We compare the association between population insurance status change and ED visit rate change between a 24-month (2012-2013) pre-ACA period and a 24-month post-ACA (2014-2015) period across 88 socioeconomically diverse areas of Illinois. METHODS: We used annual American Community Survey estimates for 2012-2015 to obtain insurance status changes for uninsured, private, Medicaid, and Medicare (disability) populations of 88 Illinois Public Use Micro Areas (PUMAs), areas with a mean of about 90,000 age 18-64 residents...
August 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28868612/the-volume-outcome-relationship-revisited-practice-indeed-makes-perfect
#19
Corinna Hentschker, Roman Mennicken
OBJECTIVE: To examine the causal effect of a hospital's experience with treating hip fractures (volume) on patient treatment outcomes. DATA SOURCES: We use a full sample of administrative data from German hospitals for 2007. The data provide detailed information on patients and hospitals. We also reference the hospitals' addresses and the zip codes of patients' place of residence. STUDY DESIGN: We apply an instrumental variable approach to address endogeneity concerns due to reverse causality and unobserved patient heterogeneity...
September 4, 2017: Health Services Research
https://www.readbyqxmd.com/read/28868515/comparison-of-wildfire-smoke-estimation-methods-and-associations-with-cardiopulmonary-related-hospital-admissions
#20
Ryan W Gan, Bonne Ford, William Lassman, Gabriele Pfister, Ambarish Vaidyanathan, Emily Fischer, John Volckens, Jeffrey R Pierce, Sheryl Magzamen
Climate forecasts predict an increase in frequency and intensity of wildfires. Associations between health outcomes and population exposure to smoke from Washington 2012 wildfires were compared using surface monitors, chemical-weather models, and a novel method blending three exposure information sources. The association between smoke particulate matter ≤2.5 μm in diameter (PM2.5) and cardiopulmonary hospital admissions occurring in Washington from 1 July to 31 October 2012 was evaluated using a time-stratified case-crossover design...
March 2017: Geohealth
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