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https://www.readbyqxmd.com/read/28722536/travel-burden-associated-with-granulocyte-colony-stimulating-factor-administration-in-a-medicare-aged-population-a-geospatial-analysis
#1
J Mark Stephens, Mark Bensink, Charles Bowers, Christopher S Hollenbeak
OBJECTIVE: Prophylaxis with granulocyte colony-stimulating factors (G-CSFs) is recommended for patients receiving myelosuppressive chemotherapy regimens with a high risk of febrile neutropenia (FN). G-CSFs should be administered starting the day after chemotherapy, necessitating return trips to the oncology clinic at the end of each cycle. We examined the travel burden related to prophylactic G-CSF injections after chemotherapy in the United States (US). METHODS: We used 2012-2014 Medicare claims data to identify a national cohort of beneficiaries age 65+ with non-myeloid cancers who received both chemotherapy and prophylactic G-CSFs...
July 19, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28717638/spatial-patterns-and-impacts-of-environmental-and-climatic-factors-on-canine-sinonasal-aspergillosis-in-northern-california
#2
Monise Magro, Jane Sykes, Polina Vishkautsan, Beatriz Martínez-López
Sinonasal aspergillosis (SNA) causes chronic nasal discharge in dogs and has a worldwide distribution, although most reports of SNA in North America originate from the western USA. SNA is mainly caused by Aspergillus fumigatus, a ubiquitous saprophytic filamentous fungus. Infection is thought to follow inhalation of spores. SNA is a disease of the nasal cavity and/or sinuses with variable degrees of local invasion and destruction. While some host factors appear to predispose to SNA (such as belonging to a dolichocephalic breed), environmental risk factors have been scarcely studied...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28716771/an-intervention-using-gamification-to-increase-human-immunodeficiency-virus-and-sexually-transmitted-infection-screening-among-young-men-who-have-sex-with-men-in-california-rationale-and-design-of-stick-to-it
#3
Christopher M Mejia, Daniel Acland, Raluca Buzdugan, Reva Grimball, Lauren Natoli, Mark R McGrath, Jeffrey D Klausner, Sandra I McCoy
BACKGROUND: In the United States, young men who have sex with men (YMSM) remain disproportionately affected by human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs). Although routine HIV/STI screening is pivotal to the timely diagnosis of HIV and STIs, initiation of appropriate treatment, and reduced onward disease transmission, repeat screening is underused. Novel interventions that incorporate elements of games, an approach known as gamification, have the potential to increase routinization of HIV/STI screening among YMSM...
July 17, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28714970/bone-marrow-adipocytes-promote-the-regeneration-of-stem-cells-and-haematopoiesis-by-secreting-scf
#4
Bo O Zhou, Hua Yu, Rui Yue, Zhiyu Zhao, Jonathan J Rios, Olaia Naveiras, Sean J Morrison
Endothelial cells and leptin receptor(+) (LepR(+)) stromal cells are critical sources of haematopoietic stem cell (HSC) niche factors, including stem cell factor (SCF), in bone marrow. After irradiation or chemotherapy, these cells are depleted while adipocytes become abundant. We discovered that bone marrow adipocytes synthesize SCF. They arise from Adipoq-Cre/ER(+) progenitors, which represent ∼5% of LepR(+) cells, and proliferate after irradiation. Scf deletion using Adipoq-Cre/ER inhibited haematopoietic regeneration after irradiation or 5-fluorouracil treatment, depleting HSCs and reducing mouse survival...
July 17, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28710221/trends-in-readmission-rates-for-safety-net-hospitals-and-non-safety-net-hospitals-in-the-era-of-the-us-hospital-readmission-reduction-program-a-retrospective-time-series-analysis-using-medicare-administrative-claims-data-from-2008-to-2015
#5
Amy M Salerno, Leora I Horwitz, Ji Young Kwon, Jeph Herrin, Jacqueline N Grady, Zhenqiu Lin, Joseph S Ross, Susannah M Bernheim
OBJECTIVE: To compare trends in readmission rates among safety net and non-safety net hospitals under the US Hospital Readmission Reduction Program (HRRP). DESIGN: A retrospective time series analysis using Medicare administrative claims data from January 2008 to June 2015. SETTING: We examined 3254 US hospitals eligible for penalties under the HRRP, categorised as safety net or non-safety net hospitals based on the hospital's proportion of patients with low socioeconomic status...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28709420/area-based-socioeconomic-factors-and-human-papillomavirus-hpv-vaccination-among-teen-boys-in-the-united-states
#6
Kevin A Henry, Allison L Swiecki-Sikora, Antoinette M Stroup, Echo L Warner, Deanna Kepka
BACKGROUND: This study is the first to examine associations between several area-based socioeconomic factors and human papillomavirus (HPV) vaccine uptake among boys in the United States (U.S.). METHODS: Data from the 2012-2013 National Immunization Survey-Teen restricted-use data were analyzed to examine associations of HPV vaccination initiation (receipt of ≥1 dose) and series completion (receipt of three doses) among boys aged 13-17 years (N = 19,518) with several individual-level and ZIP Code Tabulation Area (ZCTA) census measures...
July 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28704512/a-role-for-the-drosophila-zinc-transporter-zip88e-in-protecting-against-dietary-zinc-toxicity
#7
Christopher D Richards, Coral G Warr, Richard Burke
Zinc absorption in animals is thought to be regulated in a local, cell autonomous manner with intestinal cells responding to dietary zinc content. The Drosophila zinc transporter Zip88E shows strong sequence similarity to Zips 42C.1, 42C.2 and 89B as well as mammalian Zips 1, 2 and 3, suggesting that it may act in concert with the apically-localised Drosophila zinc uptake transporters to facilitate dietary zinc absorption by importing ions into the midgut enterocytes. However, the functional characterisation of Zip88E presented here indicates that Zip88E may instead play a role in detecting and responding to zinc toxicity...
2017: PloS One
https://www.readbyqxmd.com/read/28693838/socioeconomic-status-gender-and-burn-injury-a-retrospective-review
#8
Sharmila Dissanaike, Daniel Ha, Diana Mitchell, Eneko Larumbe
Burn injury rates appear to be influenced by socioeconomic status (SES) and gender globally, but the impact of poverty and gender on burn injury has not been studied in a developed country. This study was a retrospective chart review conducted at a regional burn center in the Southwest US that included 340 patients with TBSA burns >15%. SES was determined using zip code and US census data. The distribution of mechanism of injury was significantly different by gender (χ(2)(6) = 36.14, p < 0001), but not significantly different by SES (χ(2)(12) = 19...
June 30, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28692400/developing-syndromic-surveillance-to-monitor-and-respond-to-adverse-health-events-related-to-psychoactive-substance-use-methods-and-applications
#9
Michelle L Nolan, Hillary V Kunins, Ramona Lall, Denise Paone
INTRODUCTION: Recent increases in drug overdose deaths, both in New York City and nationally, highlight the need for timely data on psychoactive drug-related morbidity. We developed drug syndrome definitions for syndromic surveillance to monitor drug-related emergency department (ED) visits in real time. MATERIALS AND METHODS: We used 2012 archived syndromic surveillance data from New York City hospitals to develop definitions for psychoactive drug-related syndromes...
July 2017: Public Health Reports
https://www.readbyqxmd.com/read/28689925/a-geographical-workforce-analysis-of-hand-therapy-services-in-relation-to-us-population-characteristics
#10
Caroline W Stegink-Jansen, Prisca M Collins, Ronald W Lindsey, James L Wilson
INTRODUCTION: A paucity of work force planning literature exists for hand therapy services. PURPOSE: This descriptive study aimed to map the geographical distribution of US Certified Hand Therapists (CHT) and describe characteristics of US populations living in respective CHT workplace areas. METHODS: A de-identified Zip Code list of all active CHTs through April 2016 from the Hand Therapy Certification Commission, included 5572 CHTs with US Census Zip Code Tabulation Areas (ZCTA)...
July 6, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28688994/comparison-of-30-day-emergency-department-bouncebacks-after-pediatric-versus-adult-urologic-surgery
#11
Courtney L Shepard, Julian Wan
INTRODUCTION: More pediatric patients seem to present to the emergency department (ED) for non-urgent matters after urologic procedures than adult patients. Under new and expanding healthcare reform, pediatric urologists may be penalized for these visits. We compare our 30-day postoperative bounceback rates to the ED and the acuity of the concerns in these populations. MATERIALS AND METHODS: All urology consults at our institution are maintained on a prospectively tracked database...
June 20, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28685864/rural-and-appalachian-disparities-in-neonatal-abstinence-syndrome-incidence-and-access-to-opioid-abuse-treatment
#12
Joshua D Brown, Amie J Goodin, Jeffery C Talbert
OBJECTIVE: Incidence of neonatal abstinence syndrome (NAS) is increasing due to the rise in opioid use. Rural states like Kentucky have been disproportionally impacted by opioid abuse, and this study determines NAS burden nationally and in Kentucky while quantifying differences in access to care between Appalachian and non-Appalachian counties. METHODS: NAS rates were calculated using National (2013) and Kentucky (2008-2014) National Inpatient Sample discharge data...
July 7, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/28680762/tumor-targeted-il-12-combined-with-local-irradiation-leads-to-systemic-tumor-control-via-abscopal-effects-in-vivo
#13
Franziska Eckert, Ivan Jelas, Moritz Oehme, Stephan M Huber, Katja Sonntag, Christian Welker, Stephen D Gillies, Wolfgang Strittmatter, Daniel Zips, Rupert Handgretinger, Karin Schilbach
NHS-IL12 is an immunocytokine, a fusion protein of IL12's functional domains and a necrosis-targeting antibody, which has shown significant effects against human rhabdomyosarcoma xenografts in a humanized tumor model, including terminal growth arrest and differentiation of the tumor cells. Here, we locally irradiated the tumors, increasing necrosis and consequently intratumoral immune cytokine availability, and asked whether this effect may surmount efficacy of single treatment modality. Humanized mice bearing bilateral rhabdomyosarcoma xenografts were evaluated for tumor burden and survival after irradiation, systemic NHS-IL12 therapy or a combination of both...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28678097/the-effect-of-a-community-based-medical-school-on-the-state-and-local-physician-workforce
#14
Julie P Phillips, Andrea L Wendling, Carolyn A Fahey, Brian E Mavis
PURPOSE: To assess the effect of community-based medical education as implemented by Michigan State University College of Human Medicine (MSU-CHM), which has immersed students in diverse communities across Michigan since its founding, on the physician workforce in the six communities in which clinical campuses were initially established. METHOD: The authors used American Medical Association Masterfile data from 2011 to obtain practice locations and specialty data for all MSU-CHM graduates from 1972 through 2006...
July 3, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28676305/socioeconomic-and-demographic-predictors-of-missed-opportunities-to-provide-advanced-imaging-services
#15
McKinley Glover, Dania Daye, Omid Khalilzadeh, Oleg Pianykh, Daniel I Rosenthal, James A Brink, Efrén J Flores
PURPOSE: The extent to which racial and socioeconomic disparities exist in accessing clinically appropriate, advanced diagnostic imaging has not been well studied. This study assesses the relationship between demographic and socioeconomic factors and the incidence of imaging missed care opportunities (IMCOs). METHODS: We performed a retrospective review of outpatient CT and MRI appointments at a quaternary academic medical center and affiliated outpatient facilities during a 12-month period...
July 1, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28675874/source-apportionment-of-fine-particulate-matter-and-risk-of-term-low-birth-weight-in-california-exploring-modification-by-region-and-maternal-characteristics
#16
Connie Ng, Brian Malig, Sina Hasheminassab, Constantinos Sioutas, Rupa Basu, Keita Ebisu
Previous studies have demonstrated associations between fine particulate matter (PM2.5) and risk of term low birth weight (TLBW; birth weight<2500g and gestational weeks≥37weeks). However, it remains unclear which PM2.5 sources mainly contribute to these associations, and which subgroups (e.g. by residential region and maternal characteristics) may be more susceptible to these exposures. Using California birth records and PM2.5 data from eight monitoring sites from 2002 to 2009, we examined the relationship between exposures to total PM2...
July 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28662060/a-conserved-mitochondrial-surveillance-pathway-is-required-for-defense-against-pseudomonas-aeruginosa
#17
Elissa Tjahjono, Natalia V Kirienko
All living organisms exist in a precarious state of homeostasis that requires constant maintenance. A wide variety of stresses, including hypoxia, heat, and infection by pathogens perpetually threaten to imbalance this state. Organisms use a battery of defenses to mitigate damage and restore normal function. Previously, we described a Caenorhabditis elegans-Pseudomonas aeruginosa assay (Liquid Killing) in which toxicity to the host is dependent upon the secreted bacterial siderophore pyoverdine. Although pyoverdine is also indispensable for virulence in mammals, its cytological effects are unclear...
June 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28660679/do-avoidable-hospitalization-rates-among-older-adults-differ-by-geographic-access-to-primary-care-physicians
#18
Michael R Daly, Jennifer M Mellor, Marco Millones
OBJECTIVE: To investigate the association between older adults' potentially avoidable hospitalization rates and both a geographic measure of primary care physician (PCP) access and a standard bounded-area measure of PCP access. DATA SOURCES: State physician licensure data from the Virginia Board of Medicine. Patient-level hospital discharge data from Virginia Health Information. Area-level data from the American Community Survey and the Area Health Resources Files...
June 28, 2017: Health Services Research
https://www.readbyqxmd.com/read/28657878/air-pollution-and-mortality-in-the-medicare-population
#19
Qian Di, Yan Wang, Antonella Zanobetti, Yun Wang, Petros Koutrakis, Christine Choirat, Francesca Dominici, Joel D Schwartz
BACKGROUND: Studies have shown that long-term exposure to air pollution increases mortality. However, evidence is limited for air-pollution levels below the most recent National Ambient Air Quality Standards. Previous studies involved predominantly urban populations and did not have the statistical power to estimate the health effects in underrepresented groups. METHODS: We constructed an open cohort of all Medicare beneficiaries (60,925,443 persons) in the continental United States from the years 2000 through 2012, with 460,310,521 person-years of follow-up...
June 29, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28655815/geographic-variation-in-the-use-of-oral-anticoagulation-therapy-in-stroke-prevention-in-atrial-fibrillation
#20
Inmaculada Hernandez, Samir Saba, Yuting Zhang
BACKGROUND AND PURPOSE: Underuse of oral anticoagulation in stroke prevention in atrial fibrillation is common; however, it remains unknown how it varies geographically. The objective of this study was to evaluate geographic variation in oral anticoagulation use and in the initiation of new oral anticoagulants (NOACs). METHODS: Using 2013 to 2014 claims data from a 5% random sample of Medicare beneficiaries, we identified patients newly diagnosed with atrial fibrillation who initiated NOACs (n=8659), warfarin (n=11 771) or no oral anticoagulation therapy (n=18 226) in 2013 to 2014...
June 27, 2017: Stroke; a Journal of Cerebral Circulation
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