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https://www.readbyqxmd.com/read/28630892/disruption-of-the-axonal-trafficking-of-tyrosine-hydroxylase-mrna-impairs-catecholamine-biosynthesis-in-the-axons-of-sympathetic-neurons
#1
Armaz Aschrafi, Anthony E Gioio, Lijin Dong, Barry B Kaplan
Tyrosine hydroxylase (TH) is the enzyme that catalyzes the rate-limiting step in the biosynthesis of the catecholamine neurotransmitters. In a previous communication, evidence was provided that TH mRNA is trafficked to the axon, where it is locally translated. In addition, a 50-bp sequence element in the 3'untranslated region (3'UTR) of TH mRNA was identified that directs TH mRNA to distal axons (i.e., zip-code). In the present study, the hypothesis was tested that local translation of TH plays an important role in the biosynthesis of the catecholamine neurotransmitters in the axon and/or presynaptic nerve terminal...
May 2017: ENeuro
https://www.readbyqxmd.com/read/28630437/phylogenetic-analysis-of-f-bzip-transcription-factors-indicates-conservation-of-the-zinc-deficiency-response-across-land-plants
#2
Pedro Humberto Castro, Grmay H Lilay, Antonio Muñoz-Mérida, Jan K Schjoerring, Herlânder Azevedo, Ana G L Assunção
Basic leucine zipper (bZIP) transcription factors control important developmental and physiological processes in plants. In Arabidopsis thaliana, the three gene F-bZIP subfamily has been associated with zinc deficiency and salt stress response. Benefiting from the present abundance of plant genomic data, we performed an evolutionary and structural characterization of plant F-bZIPs. We observed divergence during seed plant evolution, into two groups and inferred different selective pressures for each. Group 1 contains AtbZIP19 and AtbZIP23 and appears more conserved, whereas Group 2, containing AtbZIP24, is more prone to gene loss and expansion events...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28626466/identification-characterization-and-functional-validation-of-drought-responsive-micrornas-in-subtropical-maize-inbreds
#3
Jayaraman Aravind, Sharma Rinku, Banduni Pooja, Mittal Shikha, Shiriga Kaliyugam, Mallana Gowdra Mallikarjuna, Arun Kumar, Atmakuri Ramakrishna Rao, Thirunavukkarasu Nepolean
MicroRNA-mediated gene regulation plays a crucial role in controlling drought tolerance. In the present investigation, 13 drought-associated miRNA families consisting of 65 members and regulating 42 unique target mRNAs were identified from drought-associated microarray expression data in maize and were subjected to structural and functional characterization. The largest number of members (14) was found in the zma-miR166 and zma-miR395 families, with several targets. However, zma-miR160, zma-miR390, zma-miR393, and zma-miR2275 each showed a single target...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28623074/geographic-variability-in-gestational-weight-gain-a-multilevel-population-based-study-of-women-having-term-births-in-florida-2005-2012
#4
Maya Tabet, Erik Nelson, Mario Schootman, Lung-Chang Chien, Jen Jen Chang
PURPOSE: We examined the extent of geographic variability in gestational weight gain (GWG), identified areas where women have suboptimal GWG, and evaluated whether individual- and area-level factors account for such variability. METHODS: We conducted a population-based cohort study including 1,385,574 women delivering term, singleton, and live births in Florida. We used a Bayesian, structured additive regression with a spatial function to analyze data from Florida's birth certificates (2005-2012) and ZIP code tabulation areas (ZCTAs; 2010 Census)...
June 1, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28613173/large-scale-crowdsourced-study-for-tone-mapped-hdr-pictures
#5
Debarati Kundu, Deepti Ghadiyaram, Alan Bovik, Brian Evans
Measuring digital picture quality, as perceived by human observers, is increasingly important in many applications in which humans are the ultimate consumers of visual information. Standard dynamic range (SDR) images provide 8 bits/color/pixel. High dynamic range (HDR) images, usually created from multiple exposures of the same scene, can provide 16 or 32 bits/color/pixel, but need to be tonemapped to SDR for display on standard monitors. Multi-exposure fusion (MEF) techniques bypass HDR creation by fusing an exposure stack directly to SDR images to achieve aesthetically pleasing luminance and color distributions...
June 8, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28611467/phytohormonal-crosstalk-modulates-the-expression-of-mir166-165s-target-class-iii-hd-zips-and-kanadi-genes-during-root-growth-in-arabidopsis-thaliana
#6
Archita Singh, Shradha Roy, Sharmila Singh, Shabari Sarkar Das, Vibhav Gautam, Sandeep Yadav, Ashutosh Kumar, Alka Singh, Sukanya Samantha, Ananda K Sarkar
Both phytohormones and non-coding microRNAs (miRNAs) play important role in root development in Arabidopsis thaliana. Mature miR166/165 s, which are derived from precursor transcripts of concerned genes, regulate developmental processes, including leaf and root patterning, by targeting Class III HOMEODOMAIN LEUCINE-ZIPPER (HD-ZIP III) transcription factors (TFs). However, their regulation through hormones remained poorly understood. Here, we show that several phytohormones dynamically regulate the spatio-temporal expression pattern of miR166/165 and target HD-ZIP IIIs in developing roots...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28610778/a-comparison-between-non-powder-gun-and-powder-gun-injuries-in-a-young-pediatric-population
#7
Jennifer J Freeman, Marielena Bachier-Rodriguez, Jessica Staszak, Alexander Feliz
INTRODUCTION: Non-powder guns (NPG) are viewed as toys for children by the general public. Literature on firearm injuries in the pediatric population is increasing, however there are still large gaps in the published literature regarding NPG. We intended to identify and compare the epidemiology, circumstances of injury and outcomes of children with NPG versus powder-gun injuries (GSW). PATIENTS AND METHODS: We performed a 6-year retrospective analysis of children 0-14 years old treated for NPG and GSW injuries at our level one pediatric trauma center...
May 29, 2017: Injury
https://www.readbyqxmd.com/read/28598574/socioeconomic-status-and-the-development-of-atrial-fibrillation-in-hispanics-african-americans-and-non-hispanic-whites
#8
Eric Shulman, Faraj Kargoli, Philip Aagaard, Ethan Hoch, Luigi Di Biase, John Fisher, Jay Gross, Soo Kim, Kevin J Ferrick, Andrew Krumerman
BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia and is associated with significant morbidity and mortality. Despite having a higher burden of traditional AF risk factors, African American and Hispanic minorities have a lower incidence of AF when compared to non-Hispanic whites, referred to as the "racial paradox." HYPOTHESIS: Lower SES among Hispanics and African Americans may help to explain the lower incidence rates of AF compared to non-Hispanic whites...
June 9, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28596952/neurodevelopmental-delay-diagnosis-rates-are-increased-in-a-region-with-aerial-pesticide-application
#9
Steven D Hicks, Ming Wang, Katherine Fry, Vignesh Doraiswamy, Eric M Wohlford
A number of studies have implicated pesticides in childhood developmental delay (DD) and autism spectrum disorder (ASD). The influence of the route of pesticide exposure on neurodevelopmental delay is not well defined. To study this factor, we examined ASD/DD diagnoses rates in an area near our regional medical center that employs yearly aerial pyrethroid pesticide applications to combat mosquito-borne encephalitis. The aim of this study was to determine if areas with aerial pesticide exposure had higher rates of ASD/DD diagnoses...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28594574/a-geospatial-epidemiologic-analysis-of-nontuberculous-mycobacterial-infection-an-ecological-study-in-colorado
#10
Ettie M Lipner, David Knox, Joshua French, Jordan Rudman, Michael Strong, James L Crooks
RATIONALE: Nontuberculous mycobacteria (NTM) are ubiquitous environmental microorganisms. Infection is thought to result primarily from exposure to soil and/or water sources. NTM disease prevalence varies greatly by geographic region, but the geospatial factors influencing this variation remain unclear. OBJECTIVES: To identify socio-demographic and environmental ecologic risk factors associated with NTM infection and disease in Colorado. METHODS: We conducted an ecological study combining data from patients with a diagnosis of NTM disease from National Jewish Health's Electronic Medical Record database and zip code-level socio-demographic and environmental exposure data obtained from the U...
June 8, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28593793/erratum
#11
(no author information available yet)
Yuka A, Tan J, Baibergenova A, Barankin B, Cochrane CL, Humphrey S, Lynde CW, Marcoux D, Poulin Y, Rivers JK, Sapijaszko M, Sibbald RG, Toole J, Ulmer M, Zip C. Canadian Clinical Practice Guidelines for Rosacea. J Cutan Med Surg. 2016;20(5):432-445. Original DOI: 10.1177/1203475416650427 In the above article, the author affiliation for Ulmer M should have been listed as Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada and Carruthers & Humphrey, Vancouver, BC, Canada...
June 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28590991/risk-factors-associated-with-emergency-department-return-visits-following-trauma-system-discharge
#12
Timothy Ruttan, Karla A Lawson, Karen Piper, Matthew Wilkinson
OBJECTIVES: Little evidence exists in the pediatric trauma literature regarding what factors are associated with re-presentation to the hospital for patients discharged from the emergency department (ED). METHODS: This was a retrospective cohort study of trauma system activations at a pediatric trauma center from June 30, 2007, through June 30, 2013, who were subsequently discharged from the ED or after a brief inpatient stay. Returns within 30 days were reviewed...
June 6, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28590351/a-novel-approach-to-optimal-placement-of-new-trauma-centers-within-an-existing-trauma-system-using-geospatial-mapping
#13
Michael A Horst, Frederick B Rogers, Brian W Gross, Alan D Cook, Turner M Osler, Eric H Bradburn
BACKGROUND: Trauma system expansion is a complex process often governed by financial and health care system imperatives. We sought to propose a new, informed approach to trauma system expansion through the use of geospatial mapping. We hypothesized that geospatial mapping set to specific parameters could effectively identify optimal placement of new trauma centers (TC) within an existing trauma system. METHODS: We used Pennsylvania Trauma Systems Foundation (PTSF) registry data of adult (age ≥ 15) trauma for calendar years 2003-2015 (n=408,432), hospital demographics, road networks, and US Census data files...
June 6, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28585621/specific-dsdna-recognition-by-a-mimic-of-the-dna-binding-domain-of-the-c-myc-max-transcription-factor
#14
Yara Ruiz García, Y Vladimir Pabon-Martinez, C I Edvard Smith, Annemieke Madder
We here report on the synthesis of the first mimic of the DNA binding domain of the c-Myc/Max-bHLH-ZIP transcription factor able to selectively recognize its cognate E-box sequence 5'-CACGTG-3' through the major groove of the double-stranded DNA. The designed peptidosteroid conjugate was shown to be effective as DNA binder in the presence of excess competitor DNA.
June 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28573469/geographic-epidemiology-of-hepatocellular-carcinoma-viral-hepatitis-and-socioeconomic-position-in-new-york-city
#15
Mary M Ford, Elena Ivanina, Payal Desai, Linda Highfield, Baozhen Qiao, Maria J Schymura, Fabienne Laraque
PURPOSE: Liver cancer (hepatocellular carcinoma (HCC)) incidence and mortality rates are increasing in the United States. New York City (NYC) has a high burden of liver cancer risk factors, including hepatitis C (HCV) and hepatitis B (HBV) infection, which disproportionately affect persons of low socioeconomic position. Identifying neighborhoods with HCC disparities is essential to effectively define targeted cancer control strategies. METHODS: New York State Cancer Registry data from 1 January 2001 through 31 December 2012 were matched with NYC HCV and HBV surveillance data...
June 1, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28569115/associations-between-bicycling-for-transportation-and-cardiometabolic-risk-factors-among-minneapolis-saint-paul-area-commuters-a-cross-sectional-study-in-working-age-adults
#16
Aaron T Berger, Xinyi Lisa Qian, Mark A Pereira
PURPOSE: This study describes the association between frequency of bicycling for active transportation and modifiable cardiometabolic risk factors in the Minneapolis-Saint Paul (MSP) metropolitan area. DESIGN: We conducted an online survey from a convenience sample of likely bicycle commuters. SETTING: Participants were e-mailed invitations including a link to the online survey. PARTICIPANTS: Participants (n = 1450, 15...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28556761/accuracy-of-the-fitbit-zip-for-measuring-steps-for-adolescents-with-visual-impairments
#17
Justin A Haegele, Ali S Brian, Donna Wolf
Our purpose in this study was to document the criterion validity of the Fitbit Zip for measuring steps taken by youth with visual impairments (VI). A secondary purpose was to determine whether walking pace, mounting position, or relative position to the user's mobility device impacted the criterion validity of the device. Fourteen adolescent-aged individuals (Mage = 15.4; 13 male and 1 female) with VI participated in this study. Participants wore four Fitbit Zips at different mounting positions and completed two, 2-min walking trials while the lead investigator hand tallied steps...
April 2017: Adapted Physical Activity Quarterly: APAQ
https://www.readbyqxmd.com/read/28555148/genome-wide-identification-of-orthologous-zip-genes-associated-with-zinc-and-iron-translocation-in-setaria-italica
#18
Ganesh Alagarasan, Mahima Dubey, Kumar S Aswathy, Girish Chandel
Genes in the ZIP family encode transcripts to store and transport bivalent metal micronutrient, particularly iron (Fe) and or zinc (Zn). These transcripts are important for a variety of functions involved in the developmental and physiological processes in many plant species, including most, if not all, Poaceae plant species and the model species Arabidopsis. Here, we present the report of a genome wide investigation of orthologous ZIP genes in Setaria italica and the identification of 7 single copy genes. RT-PCR shows 4 of them could be used to increase the bio-availability of zinc and iron content in grains...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28551861/determinants-of-clinic-absenteeism-a-novel-method-of-examining-distance-from-clinic-and-transportation
#19
Ryan W Dobbs, Neha R Malhotra, Brandon M Caldwell, Raymond Rojas, Daniel M Moreira, Michael R Abern
Delayed treatment and non-adherence are associated with inferior prostate cancer (CaP) outcomes. Missed clinic appointments (MA) are one form of non-adherence that may be preventable. We conducted a retrospective cohort study of 1341 scheduled clinic encounters for men referred to an academic urology clinic for evaluation of known or suspected CaP. Driving distance and public transit times were calculated using a Google Distance Matrix API algorithm. Zip code level data regarding socioeconomic status was obtained from the 2013 American Community Survey...
May 27, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28550998/anticipating-anonymity-in-screening-program-databases
#20
Rafael Caballero, Sagar Sen, Jan F Nygård
In this paper, we propose a technique for improving anonymity in screening program databases to increase the privacy for the participants in these programs. The data generated by the invitation process (screening centre, appointment date) is often made available to researchers for medical research and for evaluation and improvement of the screening program. This information, combined with other personal quasi-identifiers such as the ZIP code, gender or age, can pose a risk of disclosing the identity of the individuals participating in the program, and eventually their test results...
July 2017: International Journal of Medical Informatics
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