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https://www.readbyqxmd.com/read/29138931/rna-seq-analysis-reveals-the-distinctive-adaxial-abaxial-polarity-in-the-asymmetric-one-theca-stamen-of-canna-indica
#1
Xueyi Tian, Pu Zou, Mingzhi Miao, Zulin Ning, Jingping Liao
Proper establishment of adaxial-abaxial polarity is essential for the development of lateral organs, while former researches were mostly focused on the polarity regulation in leaves, and little is known in stamens, especially in the asymmetric ones. Canna indica (Zingiberales: Cannaceae) is a widely cultivated ornamental plant and the representative species to study the evolutionary development of Zingiberales. The androecium of Canna indica comprises 3-4 petaloid staminodes and a fertile stamen (FS), which consists of a one-theca anther and a petaloid appendage...
November 14, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29138296/the-genetics-of-pkm%C3%AE-and-memory-maintenance
#2
REVIEW
Todd Charlton Sacktor, Johannes W Hell
Elucidating the molecular mechanisms that maintain long-term memory is a fundamental goal of neuroscience. Accumulating evidence suggests that persistent signaling by the atypical protein kinase C (PKC) isoform protein kinase Mζ (PKMζ) might maintain synaptic long-term potentiation (LTP) and long-term memory. However, the role of PKMζ has been challenged by genetic data from PKMζ-knockout mice showing intact LTP and long-term memory. Moreover, the PKMζ inhibitor peptide ζ inhibitory peptide (ZIP) reverses LTP and erases memory in both wild-type and knockout mice...
November 14, 2017: Science Signaling
https://www.readbyqxmd.com/read/29132647/normative-data-for-the-patient-rated-wrist-evaluation-questionnaire
#3
Marjolein A M Mulders, Suzanne C Kleipool, Siem A Dingemans, Percy V van Eerten, Tim Schepers, J Carel Goslings, Niels W L Schep
STUDY DESIGN: Cross-sectional study. INTRODUCTION: The Patient-Rated Wrist Evaluation (PRWE) questionnaire is used to evaluate functional outcomes after treatment of wrist and hand injuries and nontraumatic conditions. Since patients commonly present with an injury, it is impossible to assess preinjury physical functioning. Therefore, it is important to be aware of the population-based normative data. PURPOSE OF THE STUDY: The aim of this study was to determine the normative data for the PRWE questionnaire...
November 10, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29130001/are-patients-traveling-for-intraoperative-radiation-therapy
#4
Kelsey E Larson, Stephanie A Valente, Chirag Shah, Rahul D Tendulkar, Sheen Cherian, Courtney Yanda, Chao Tu, Jessica Echle, Stephen R Grobmyer
Purpose: One benefit of intraoperative radiation therapy (IORT) is that it usually requires a single treatment, thus potentially eliminating distance as a barrier to receipt of whole breast irradiation. The aim of this study was to evaluate the distance traveled by IORT patients at our institution. Methods: Our institutional prospective registry was used to identify IORT patients from 10/2011 to 2/2017. Patient's home zip code was compared to institution zip code to determine travel distance...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29122082/the-relationship-between-social-determinants-of-health-and-utilization-of-tertiary-rhinology-care
#5
Madeleine B Samuelson, Rakesh K Chandra, Justin H Turner, Paul T Russell, David O Francis
BACKGROUND: Chronic rhinosinusitis (CRS) has a high prevalence and significant cost and quality of life implications. Many types of practitioners care for patients with rhinosinusitis; however, patients with chronic or complicated conditions are often referred for tertiary rhinology services. It is unclear how social determinants of health affect access and utilization of these services. A better understanding of social barriers to tertiary rhinology care is needed to reduce health care disparities and improve health outcomes...
November 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29121561/flip-an-assisting-software-in-structure-based-drug-design-using-fingerprint-of-protein-ligand-interaction-profiles
#6
Ali Hajiebrahimi, Younes Ghasemi, Amirhossein Sakhteman
With the growing number of labor-intensive data in the pharmaceutical industries and public domain for protein-ligand complexes, a significant challenge is still remaining in managing and leveraging this vast information. Here, a standalone application is presented for analysis, organization, and illustration of structural data and molecular interactions for exploiting 3D-structures into simple 1D fingerprints. The utility of the approach was shown in unraveling a feasible solution for post-processing of docking results in parallel with providing fruitful analysis for users in order to investigate molecular interactions...
November 1, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29120360/elemental-ingredients-in-the-macrophage-cocktail-role-of-zip8-in-host-response-to-mycobacterium-tuberculosis
#7
REVIEW
Charlie J Pyle, Abul K Azad, Audrey C Papp, Wolfgang Sadee, Daren L Knoell, Larry S Schlesinger
Tuberculosis (TB) is a global epidemic caused by the infection of human macrophages with the world's most deadly single bacterial pathogen, Mycobacterium tuberculosis (M.tb). M.tb resides in a phagosomal niche within macrophages, where trace element concentrations impact the immune response, bacterial metal metabolism, and bacterial survival. The manipulation of micronutrients is a critical mechanism of host defense against infection. In particular, the human zinc transporter Zrt-/Irt-like protein 8 (ZIP8), one of 14 ZIP family members, is important in the flux of divalent cations, including zinc, into the cytoplasm of macrophages...
November 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29119681/weight-loss-success-of-participants-residing-in-rural-and-urban-areas
#8
Elise Mench, Delia West, Rebecca Krukowski, Jean Harvey
PURPOSE: Rural residents are significantly more likely to be overweight and obese than are urban residents. However, few data have compared weight control program responses in these population groups. Therefore, the primary aim of this study was to evaluate the weight loss outcomes of participants in a multisite, online behavioral intervention by residential location (rural vs urban) and, second, assess any possible differences in adherence to treatment goals. METHODS: A total of 492 adult participants (mean BMI = 35...
November 9, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/29118034/cardiovascular-effects-of-long-term-exposure-to-air-pollution-a-population-based-study-with-900%C3%A2-845%C3%A2-person-years-of-follow-up
#9
Hyeanji Kim, Joonghee Kim, Sunhwa Kim, Si-Hyuck Kang, Hee-Jun Kim, Ho Kim, Jongbae Heo, Seung-Muk Yi, Kyuseok Kim, Tae-Jin Youn, In-Ho Chae
BACKGROUND: Studies have shown that long-term exposure to air pollution such as fine particulate matter (≤2.5 μm in aerodynamic diameter [PM2.5]) increases the risk of all-cause and cardiovascular mortality. To date, however, there are limited data on the impact of air pollution on specific cardiovascular diseases. This study aimed to evaluate cardiovascular effects of long-term exposure to air pollution among residents of Seoul, Korea. METHODS AND RESULTS: Healthy participants with no previous history of cardiovascular disease were evaluated between 2007 and 2013...
November 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29117247/a-mobile-loop-near-the-active-site-acts-as-a-switch-between-the-dual-activities-of-a-viral-protease-deubiquitinase
#10
Isabelle Jupin, Maya Ayach, Lucile Jomat, Sonia Fieulaine, Stéphane Bressanelli
The positive-strand RNA virus Turnip yellow mosaic virus (TYMV) encodes an ovarian tumor (OTU)-like protease/deubiquitinase (PRO/DUB) protein domain involved both in proteolytic processing of the viral polyprotein through its PRO activity, and in removal of ubiquitin chains from ubiquitylated substrates through its DUB activity. Here, the crystal structures of TYMV PRO/DUB mutants and molecular dynamics simulations reveal that an idiosyncratic mobile loop participates in reversibly constricting its unusual catalytic site by adopting "open", "intermediate" or "closed" conformations...
November 8, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29117042/impact-of-patient-distance-from-ventricular-assist-device-implanting-center-on-short-and-long-term-outcomes
#11
Ashwin K Ravichandran, Palak Shah, Ramesh Singh, Keith D Aaronson, Francis D Pagani, John Stulak, Shannon M Dunlay, Todd F Dardas, Nahush A Mokadam, Christopher T Salerno, Jennifer A Cowger
Highly specialized left ventricular assist device care is not readily available in many areas, potentially limiting access to therapy. This retrospective analysis examines the relationship of outcomes by patient distance from implanting left ventricular assist device center within the Mechanical Circulatory Support Research Network. Zip codes were used to calculate patient distance, with the primary outcome of interest being 3-year survival by distance from the surgical center. Secondary outcomes included 90-day survival and incident event rates for the following: gastrointestinal bleeding, infection, cerebral event, and pump thrombosis...
November 7, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29116968/antiemetic-prophylaxis-as-a-marker-of-health-care-disparities-in-the-national-anesthesia-clinical-outcomes-registry
#12
Michael H Andreae, Jonah S Gabry, Ben Goodrich, Robert S White, Charles Hall
BACKGROUND: US health care disparities persist despite repeated countermeasures. Research identified race, ethnicity, gender, and socioeconomic status as factors, mediated through individual provider and/or systemic biases; little research exists in anesthesiology. We investigated antiemetic prophylaxis as a surrogate marker for anesthesia quality by individual providers because antiemetics are universally available, indicated contingent on patient characteristics (gender, age, etc), but independent of comorbidities and not yet impacted by regulatory or financial constraints...
November 7, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29115926/co-expression-network-analysis-of-the-transcriptomes-of-rice-roots-exposed-to-various-cadmium-stresses-reveals-universal-cadmium-responsive-genes
#13
Mingpu Tan, Dan Cheng, Yuening Yang, Guoqiang Zhang, Mengjie Qin, Jun Chen, Yahua Chen, Mingyi Jiang
BACKGROUND: The migration of cadmium (Cd) from contaminated soil to rice is a cause for concern. However, the molecular mechanism underlying the response of rice roots to various Cd stresses remains to be clarified from the viewpoint of the co-expression network at a system-wide scale. RESULTS: We employed a comparative RNAseq-based approach to identify early Cd-responsive differentially expressed genes (DEGs) in rice 'Nipponbare' seedling roots after 1 h of high-Cd treatment...
November 7, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29113508/outcomes-of-children-with-critical-bronchiolitis-living-in-poor-communities
#14
Katherine N Slain, Steven L Shein, Anne G Stormorken, Meredith C G Broberg, Alexandre T Rotta
There are established associations between adverse health outcomes and poverty, but little is known regarding these associations in critically ill children. We hypothesized that living in poorer communities would be associated with unfavorable outcomes in children with critical bronchiolitis. This retrospective study included children with bronchiolitis admitted to a pediatric intensive care unit (PICU) over a 2-year period. Median household income was estimated from patient ZIP codes and 2014 US Census Bureau data...
November 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/29112197/association-of-genetic-ancestry-with-striatal-dopamine-d2-d3-receptor-availability
#15
C E Wiers, P C Towb, C A Hodgkinson, P-H Shen, C Freeman, G Miller, E Lindgren, E Shokri-Kojori, Ş B Demiral, S W Kim, D Tomasi, H Sun, G-J Wang, D Goldman, N D Volkow
Despite ethnic differences in allele frequencies of variants in dopaminergic genes associated with dopamine D2/D3 receptor availability (D2R), no study to date has investigated the relationship between genetic ancestry and striatal D2R. Here, we show that ancestry-informative markers significantly predict dorsal striatal D2R in 117 healthy ethnically diverse residents of the New York metropolitan area using Positron Emission Tomography (PET) with [(11)C]raclopride (P<0.0001), while correcting for age, sex, BMI, education, smoking status, and estimated socioeconomic status (ZIP codes)...
November 7, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29108681/legionella-contamination-in-warm-water-systems-a-species-level-survey
#16
Thorsten Dilger, Holger Melzl, André Gessner
Legionellae constitute a frequent contamination of warm water systems and can lead to serious infections. Therefore, in many countries it is mandatory to monitor warm water systems for their presence. The method of examination in Germany is regulated by guideline ISO 11731 and DIN EN ISO 11731-2, and the results are reported as concentration of Legionella spp. Only limited information is available on the presence of individual species of Legionellae in the examined systems, since most investigations and research focus solely on Legionella pneumophila as the most important human pathogen...
November 3, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29107961/national-substance-use-patterns-on-twitter
#17
Hsien-Wen Meng, Suraj Kath, Dapeng Li, Quynh C Nguyen
PURPOSE: We examined openly shared substance-related tweets to estimate prevalent sentiment around substance use and identify popular substance use activities. Additionally, we investigated associations between substance-related tweets and business characteristics and demographics at the zip code level. METHODS: A total of 79,848,992 tweets were collected from 48 states in the continental United States from April 2015-March 2016 through the Twitter API, of which 688,757 were identified as being related to substance use...
2017: PloS One
https://www.readbyqxmd.com/read/29106914/geographic-and-demographic-variation-in-use-of-ranibizumab-versus-bevacizumab-for-neovascular-age-related-macular-degeneration-in-the-united-states
#18
Emily W Gower, Joshua D Stein, Nakul S Shekhawat, Shravani Mikkilineni, Taylor S Blachley, Nicholas M Pajewski
PURPOSE: To examine demographic and geographic variation in the use of ranibizumab and bevacizumab for the treatment of neovascular age-related macular degeneration (AMD) among Medicare beneficiaries. DESIGN: Retrospective cohort study. METHODS: Using a 100% sample of Medicare claims data, we evaluated Medicare beneficiaries (N = 195 812) with an index claim for neovascular AMD between July 1, 2006, and June 30, 2009, to determine whether beneficiaries first received ranibizumab or bevacizumab following initial diagnosis...
October 26, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29105867/structural-destabilization-of-tropomyosin-induced-by-the-cardiomyopathy-linked-mutation-r21h
#19
Thu Ly, Inna Krieger, Dmitri Tolkatchev, Cheyenna Krone, Timothy Moural, Fadel A Samatey, ChulHee Kang, Alla S Kostyukova
The missense mutation R21H in striated muscle tropomyosin is associated with hypertrophic cardiomyopathy, a genetic cardiac disease and a leading cause of sudden cardiac death in young people. Tropomyosin adopts conformation of a coiled-coil that is critical for regulation of muscle contraction. In this study, we investigated the effects of the R21H mutation on the coiled-coil structure of tropomyosin and its interactions with its binding partners, tropomodulin and leiomodin. Using circular dichroism and isothermal titration calorimetry, we found that the mutation profoundly destabilized the structural integrity of αTM1a1-28 Zip, a chimeric peptide containing the first 28 residues of tropomyosin...
November 6, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29104296/efficient-computation-of-reduced-regression-models
#20
Stuart R Lipsitz, Garrett M Fitzmaurice, Debajyoti Sinha, Nathanael Hevelone, Edward Giovannucci, Quoc-Dien Trinh, Jim C Hu
We consider settings where it is of interest to fit and assess regression submodels that arise as various explanatory variables are excluded from a larger regression model. The larger model is referred to as the full model; the submodels are the reduced models. We show that a computationally efficient approximation to the regression estimates under any reduced model can be obtained from a simple weighted least squares (WLS) approach based on the estimated regression parameters and covariance matrix from the full model...
2017: American Statistician
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