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https://www.readbyqxmd.com/read/28221376/cell-biology-zipping-the-casparian-strip
#1
Silvia Melina Velasquez, Jürgen Kleine-Vehn
No abstract text is available yet for this article.
August 2, 2016: Nature Plants
https://www.readbyqxmd.com/read/28215533/plastid-protein-targeting-preprotein-recognition-and-translocation
#2
P Chotewutmontri, K Holbrook, B D Bruce
Eukaryotic organisms are defined by their endomembrane system and various organelles. The membranes that define these organelles require complex protein sorting and molecular machines that selectively mediate the import of proteins from the cytosol to their functional location inside the organelle. The plastid possibly represents the most complex system of protein sorting, requiring many different translocons located in the three membranes found in this organelle. Despite having a small genome of its own, the vast majority of plastid-localized proteins is nuclear encoded and must be posttranslationally imported from the cytosol...
2017: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/28205653/phosphorylation-of-zinc-channel-zip7-drives-mapk-pi3k-and-mtor-growth-and-proliferation-signalling
#3
T Nimmanon, S Ziliotto, S Morris, L Flanagan, K M Taylor
Zinc is an essential trace element participating in diverse biological processes. Cellular zinc levels are strictly controlled by two families of transport proteins: ZIP channels (SLC39A) and ZnT transporters (SLC30A). ZIP channels increase cytosolic zinc levels by importing zinc into cells or releasing zinc from intracellular stores such as the ER. Among all the 14 human members of the ZIP family, ZIP7 is a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation on residues S275 and S276, resulting in activation of multiple downstream pathways...
February 16, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28196847/housing-discrimination-residential-racial-segregation-and-colorectal-cancer-survival-in-southeastern-wisconsin
#4
Yuhong Zhou, Amin Bemanian, Kirsten M M Beyer
BACKGROUND: Residential racial segregation is still neglected in contemporary examinations of racial health disparities, including studies of cancer. Even fewer studies examine the processes by which segregation occurs, such as through housing discrimination. This study aims to examine relationships among housing discrimination, segregation, and colorectal cancer survival in southeastern Wisconsin. METHODS: Cancer incidence data were obtained from the Wisconsin Cancer Reporting System for two southeastern Wisconsin metropolitan areas...
February 14, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28196538/functional-studies-of-drosophila-zinc-transporters-reveal-the-mechanism-for-zinc-excretion-in-malpighian-tubules
#5
Sai Yin, Qiuhong Qin, Bing Zhou
BACKGROUND: Zinc is an essential metal involved in many physiological processes. Previous work has identified a set of zinc transporters involved in Drosophila dietary zinc absorption. However, zinc excretion and reabsorption, the other two important processes to maintain zinc homeostasis, are not as well understood. In this work, we screened all the potential zinc transporter Zip (SLC39) and ZnT (SLC30) members for their likely roles in zinc excretion in Malpighian tubules, an insect organ functionally analogous to mammalian kidneys...
February 14, 2017: BMC Biology
https://www.readbyqxmd.com/read/28191617/impacts-of-extremely-high-temperature-and-heatwave-on-heatstroke-in-chongqing-china
#6
Yonghong Li, Chengcheng Li, Shuquan Luo, Jinyu He, Yibin Cheng, Yinlong Jin
Few studies have reported the quantitative association between heat and heatstroke (HS) occurrence, particularly in China. The aim of this study was to quantitatively assess the association between high temperature/heatwave and HS occurrence in Chongqing. The daily HS data from 2009 to 2013 of Chongqing were extracted from Chongqing Center for Disease Control and Prevention. A Zero-inflated Poisson regression model (ZIP) with a logistic distribution was used to quantitatively analyze the impacts of the daily maximum temperature (Tmax) over the threshold on HS occurrence by gender, age, and severity of HS, after controlling for covariates including day of the week (DOW), relative humidity, and daily temperature range...
February 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28187763/the-method-of-attachment-influences-accelerometer-based-activity-data-in-dogs
#7
Kyle W Martin, Anastasia M Olsen, Colleen G Duncan, Felix M Duerr
BACKGROUND: Accelerometer-based activity monitoring is a promising new tool in veterinary medicine used to objectively assess activity levels in dogs. To date, it is unknown how device orientation, attachment method, and attachment of a leash to the collar holding an accelerometer affect canine activity data. It was our goal to evaluate whether attachment methods of accelerometers affect activity counts. Eight healthy, client-owned dogs were fitted with two identical neck collars to which two identical activity monitors were attached using six different methods of attachment...
February 10, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28187730/adherence-to-treatment-guidelines-the-association-between-stroke-risk-stratified-comparing-chads2-and-cha2ds2-vasc-score-levels-and-warfarin-prescription-for-adult-patients-with-atrial-fibrillation
#8
Scott A Chapman, Catherine A St Hill, Meg M Little, Michael T Swanoski, Shellina R Scheiner, Kenric B Ware, M Nawal Lutfiyya
BACKGROUND: Ischemic stroke is a risk associated with atrial fibrillation (AF) and is estimated to occur five times more often in afflicted patients than in those without AF. Anti-thrombotic therapy is recommended for the prevention of ischemic stroke. Risk stratification tools, such as the CHADS2, and more recently the CHA2DS2-VASc, for predicting stroke in patients with AF have been developed to determine the level of stroke risk and assist clinicians in the selection of antithrombotic therapy...
February 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28187161/modeling-hormonal-control-of-cambium-proliferation
#9
Vladyslav Oles, Alexander Panchenko, Andrei Smertenko
Rise of atmospheric CO2 is one of the main causes of global warming. Catastrophic climate change can be avoided by reducing emissions and increasing sequestration of CO2. Trees are known to sequester CO2 during photosynthesis, and then store it as wood biomass. Thus, breeding of trees with higher wood yield would mitigate global warming as well as augment production of renewable construction materials, energy, and industrial feedstock. Wood is made of cellulose-rich xylem cells produced through proliferation of a specialized stem cell niche called cambium...
2017: PloS One
https://www.readbyqxmd.com/read/28183854/linguistic-isolation-and-access-to-the-active-kidney-transplant-waiting-list-in-the-united-states
#10
Efrain Talamantes, Keith C Norris, Carol M Mangione, Gerardo Moreno, Amy D Waterman, John D Peipert, Suphamai Bunnapradist, Edmund Huang
BACKGROUND AND OBJECTIVES: Waitlist inactivity is a barrier to transplantation, because inactive candidates cannot receive deceased donor organ offers. We hypothesized that temporarily inactive kidney transplant candidates living in linguistically isolated communities would be less likely to achieve active waitlist status. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We merged Organ Procurement and Transplantation Network/United Network for Organ Sharing data with five-digit zip code socioeconomic data from the 2000 US Census...
February 9, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28182024/impact-of-hospital-and-sociodemographic-factors-on-utilization-of-drug-eluting-stents-in-2011-2012-medicare-cohort
#11
Tushar A Tuliani, Maithili Shenoy, Milind Parikh, Mauricio G Cohen, Cindy Grines, Kenneth Jutzy, Anthony Hilliard
OBJECTIVE: Insurance status is a predictor of drug-eluting stent (DES) usage. Our study sought to determine the effect of hospital and sociodemographic characteristics on utilization of DES in nationwide inpatient discharges with uniform insurance (Medicare). METHODS: We linked data from the 2011 to 2012 Medicare discharges, 2011 Medicare hospital referral region (HRR) report (racial composition of each HRR), American Hospital Association (number of beds, rural/urban location, public/private status, and academic affiliation of hospitals), and American Community Survey 2011 (median income using zip code)...
January 2017: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/28181174/zinc-dyshomeostasis-in-cardiomyocytes-after-acute-hypoxia-reoxygenation
#12
Vijaya Lakshmi Bodiga, Sandhya Thokala, Sita Mahalaxmi Kovur, Sreedhar Bodiga
Zinc dyshomeostasis may play a role in the pathogenesis of myocardial ischemia/reperfusion injury. The objective of this study was to investigate the expression profile of zinc regulated transporter like- and iron-regulated transporter-like proteins (ZIPs) and zinc transporter proteins (ZnTs) in cardiomyocytes and their modulation in response to hypoxia and reoxygenation. Adult rat ventricular myocytes (ARVMs) were subjected to 6 h of hypoxia, followed by 18 h of reoxygenation. Intracellular and extracellular zinc concentrations were determined using Fluozin-3 and Newport Green fluorescence, respectively...
February 8, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28180146/-i-think-we-ve-got-too-many-tests-prenatal-providers-reflections-on-ethical-and-clinical-challenges-in-the-practice-integration-of-cell-free-dna-screening
#13
B L Gammon, S A Kraft, M Michie, M Allyse
BACKGROUND: The recent introduction of cell-free DNA-based non-invasive prenatal screening (cfDNA screening) into clinical practice was expected to revolutionize prenatal testing. cfDNA screening for fetal aneuploidy has demonstrated higher test sensitivity and specificity for some conditions than conventional serum screening and can be conducted early in the pregnancy. However, it is not clear whether and how clinical practices are assimilating this new type of testing into their informed consent and counselling processes...
July 2016: Ethics, Medicine, and Public Health
https://www.readbyqxmd.com/read/28176298/what-does-the-u-s-medicare-administrative-claims-database-tell-us-about-initial-antiepileptic-drug-treatment-for-older-adults-with-new-onset-epilepsy
#14
Roy C Martin, Edward Faught, Jerzy P Szaflarski, Joshua Richman, Ellen Funkhouser, Kendra Piper, Lucia Juarez, Chen Dai, Maria Pisu
OBJECTIVE: Disparities in epilepsy treatment are not uncommon; therefore, we examined population-based estimates of initial antiepileptic drugs (AEDs) in new-onset epilepsy among racial/ethnic minority groups of older US Medicare beneficiaries. METHODS: We conducted retrospective analyses of 2008-2010 Medicare administrative claims for a 5% random sample of beneficiaries augmented for minority representation. New-onset epilepsy cases in 2009 had ≥1 International Classification of Diseases, Ninth Revision (ICD-9) 345...
February 7, 2017: Epilepsia
https://www.readbyqxmd.com/read/28171749/a-molecular-framework-for-the-embryonic-initiation-of-shoot-meristem-stem-cells
#15
Zhongjuan Zhang, Elise Tucker, Marita Hermann, Thomas Laux
The establishment of pluripotent stem cells is a key event during plant and animal embryogenesis, but the underlying mechanisms remain enigmatic. We show that in the flowering plant Arabidopsis thaliana, expression of the shoot meristem stem cell marker CLV3 becomes detectable in transition stage embryos. Surprisingly, the key regulator of stem cell homeostasis WUSCHEL (WUS) is expressed but dispensable for stem cell initiation. Rather, the WUS paralog WOX2, a regulator of embryo patterning initiated in the zygote, functions in this process by shielding stem cell progenitors from differentiation...
February 6, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28168891/ankyloglossia-and-lingual-frenotomy
#16
Jonathan Walsh, Anne Links, Emily Boss, David Tunkel
Objectives (1) Describe trends in the diagnosis of ankyloglossia and the use of lingual frenotomy and (2) analyze patient- and hospital-level factors as compared with the total pediatric discharge population. Study Design National database analysis. Methods We reviewed available data from 1997 to 2012 using the Kids' Inpatient Database, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality. All weighted pediatric discharges with ankyloglossia, newborn feeding difficulty, or lingual frenotomy were analyzed for variables of sex, payer, zip code median income, hospital ownership, location/teaching status, bed size, region, and children's hospital status...
February 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28168593/a-community-needs-index-for-adolescent-pregnancy-prevention-program-planning-application-of-spatial-generalized-linear-mixed-models
#17
Glen D Johnson, Kristine Mesler, Marilyn A Kacica
Objective The objective is to estimate community needs with respect to risky adolescent sexual behavior in a way that is risk-adjusted for multiple community factors. Methods Generalized linear mixed modeling was applied for estimating teen pregnancy and sexually transmitted disease (STD) incidence by postal ZIP code in New York State, in a way that adjusts for other community covariables and residual spatial autocorrelation. A community needs index was then obtained by summing the risk-adjusted estimates of pregnancy and STD cases...
February 6, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28156577/use-of-an-emr-online-portal-for-communication-with-cancer-patients
#18
Vicky Spies, Miriam B Rodin, Yifan Tu
: 147 Background: Communication with patients about their health care is vital to the physician-patient relationship. This is especially true in oncology where patients receive frequent diagnostic evaluations and their diseases are often active and evolving. In 2009, as part of "meaningful use", Congress mandated the need to establish an electronic portal for patient communication. We studied factors associated with the use of our online patient portal. METHODS: We performed a retrospective chart review of the use of our EMR online portal, MyChart...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28154106/visualizing-the-diffusion-of-digital-mammography-in-new-york-state
#19
Francis P Boscoe, Xiuling Zhang
BACKGROUND: Digital mammography saw rapid adoption during the first decade of the 2000s. We were interested in identifying the times and locations where the technology was introduced within the state of New York as a way of illustrating the uneven introduction of this technology. METHODS: Using a sample of Medicare claims data from the period 2004-2012 from women aged 65 and over without cancer, we calculated the percentage of mammograms which were digital by zip code of residence and illustrated these with a series of smoothed maps...
February 2, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28150176/health-hazards-in-the-home-an-assessment-of-a-southern-nevada-community
#20
Amanda Sokolowsky, Erika Marquez, Erin Sheehy, Casey Barber, Shawn Gerstenberger
As a sub-grantee of a Department of Housing and Urban Development (HUD) Lead Hazard Control and Healthy Homes Program, the University of Nevada, Las Vegas' Department of Environmental and Occupational Health performed lead and Healthy Homes investigations and collected data regarding conditions in the home environment in Henderson, Nevada. The purpose of this research is to characterize housing conditions in southern Nevada, compare data to census data, and to highlight the health outcomes associated with adverse housing conditions...
February 1, 2017: Journal of Community Health
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