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https://www.readbyqxmd.com/read/28098160/a-zip6-zip10-heteromer-controls-ncam1-phosphorylation-and-integration-into-focal-adhesion-complexes-during-epithelial-to-mesenchymal-transition
#1
Dylan Brethour, Mohadeseh Mehrabian, Declan Williams, Xinzhu Wang, Farinaz Ghodrati, Sepehr Ehsani, Elizabeth A Rubie, James R Woodgett, Jean Sevalle, Zhengrui Xi, Ekaterina Rogaeva, Gerold Schmitt-Ulms
The prion protein (PrP) evolved from the subbranch of ZIP metal ion transporters comprising ZIPs 5, 6 and 10, raising the prospect that the study of these ZIPs may reveal insights relevant for understanding the function of PrP. Building on data which suggested PrP and ZIP6 are critical during epithelial-to-mesenchymal transition (EMT), we investigated ZIP6 in an EMT paradigm using ZIP6 knockout cells, mass spectrometry and bioinformatic methods. Reminiscent of PrP, ZIP6 levels are five-fold upregulated during EMT and the protein forms a complex with NCAM1...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28096744/measuring-the-health-literacy-of-the-upper-midwest
#2
Caitlin J Bakker, Jonathan B Koffel, Nicole R Theis-Mahon
OBJECTIVES: Health literacy-the ability to obtain, process, and understand basic health information-is a major determinant of an individual's overall health and health care utilization. In this project, the authors examined predictors of health literacy levels, including numeracy and graphic literacy, among an adult population in the Upper Midwest. METHODS: The research was conducted at the Minnesota State Fair. Three previously validated scales were used to assess health literacy: Newest Vital Sign, the General Health Numeracy Test, and questions from Galesic and Garcia-Retamero's Graph Literacy Scale...
January 2017: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/28088399/the-timing-of-pertussis-cases-in-unvaccinated-children-in-an-outbreak-year-oregon-2012
#3
Steve G Robison, Juventila Liko
OBJECTIVE: To assess whether, during a 2012 pertussis outbreak, unvaccinated and poorly vaccinated cases occurred earlier on a community level. STUDY DESIGN: Pediatric pertussis among children 2 months to 10 years of age in the Oregon Sentinel Surveillance region during an epidemic starting at the beginning of 2012 were stratified by immunization status, age, zip code, and calendar date of disease onset. Differences in median onset as days between fully or mostly vaccinated, poorly vaccinated, and unvaccinated cases were examined overall and within local zip code areas...
January 11, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28087435/postmyelotomy-closure-of-spinal-cord-zip-lock-technique-an-initial-experience
#4
Daljit Singh, Shaam Bodeliwala, Hukum Singh, Anita Jagetia, Amit Mittal
Proper closure of the pia matter is necessary to restore the normal anatomy and prevent postoperative painful dysesthesia after excision of intramedullary spinal cord tumor. Two methods of closure of the pia have been described: welding technique and conventional suturing. Here, we report our initial experience with a new "pial press" or "zip-lock" technique for pial closure where pial layers are simply held together and plunged into each other with small micro tooth forceps. Advantages of the technique over other techniques are its less chances of suture related complications or trauma to the posterior column and simplicity of the technique...
January 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28077304/drosophila-dorsal-closure-an-orchestra-of-forces-to-zip-shut-the-embryo
#5
REVIEW
Peran Hayes, Jérôme Solon
Dorsal closure, a late-embryogenesis process, consists in the sealing of an epidermal gap on the dorsal side of the Drosophila embryo. Because of its similarities with wound healing and neural tube closure in humans, it has been extensively studied in the last twenty years. The process requires the coordination of several force generating mechanisms, that together will zip shut the epidermis. Recent works have provided a precise description of the cellular behavior at the origin of these forces and proposed quantitative models of the process...
January 7, 2017: Mechanisms of Development
https://www.readbyqxmd.com/read/28073490/mapping-pediatric-injuries-to-target-prevention-education-and-outreach
#6
Camille L Stewart, Shannon N Acker, Laura Pyle, Dwayne S Smith, Denis D Bensard, Steven L Moulton
BACKGROUND: Initiatives exist to prevent pediatric injuries, but targeting these interventions to specific populations is challenging. We hypothesized that mapping pediatric injuries by zip code could be used to identify regions requiring more interventions and resources. METHODS: We queried the trauma registries of two level I trauma centers for children 0-17years of age injured between 2009 and 2013 with home zip codes in our state. Maps were created to identify outlier zip codes...
December 30, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28062037/single-molecule-insight-into-target-recognition-by-crispr-cas-complexes
#7
M Rutkauskas, A Krivoy, M D Szczelkun, C Rouillon, R Seidel
Ribonucleoprotein (RNP) complexes from CRISPR-Cas systems have attracted enormous interest since they can be easily and flexibly reprogrammed to target any desired locus for genome engineering and gene regulation applications. Basis for the programmability is a short RNA (crRNA) inside these complexes that recognizes the target nucleic acid by base pairing. For CRISPR-Cas systems that target double-stranded DNA this results in local DNA unwinding and formation of a so-called R-loop structure. Here we provide an overview how this target recognition mechanism can be dissected in great detail at the level of a single molecule...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28058288/variations-in-weight-stigma-concerns
#8
Jessica E Cornick, Cambridge Teter, Andrew K Thaw
Over the past 40 years, obesity rates in the United States have grown significantly; these rates have not grown uniformly across the United States (18 of the 20 counties with the highest obesity rates are located in the South). Obesity increases cardiovascular disease risk factors and new research has highlighted the negative psychological effects of obesity, known as weight stigma, including decreased selfcontrol resources, over eating, and exercise avoidance. The primary objective of this study was to determine if weight stigma concerns varied regionally and if social behaviors influenced this variation...
December 9, 2016: Health Psychology Research
https://www.readbyqxmd.com/read/28057687/afresh-an-adaptive-framework-for-compression-of-reads-and-assembled-sequences-with-random-access-functionality
#9
Tom Paridaens, Glenn Van Wallendael, Wesley De Neve, Peter Lambert
MOTIVATION: The past decade has seen the introduction of new technologies that lowered the cost of genomic sequencing increasingly. We can even observe that the cost of sequencing is dropping significantly faster than the cost of storage and transmission. The latter motivates a need for continuous improvements in the area of genomic data compression, not only at the level of effectiveness (compression rate), but also at the level of functionality (e.g., random access), configurability (effectiveness vs complexity, coding tool set…), and versatility (support for both sequenced reads and assembled sequences)...
January 5, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28057442/iron-importers-zip8-and-zip14-are-expressed-in-retina-and-regulated-by-retinal-iron-levels
#10
Jacob Sterling, Samyuktha Guttha, Ying Song, Delu Song, Majda Hadziahmetovic, Joshua L Dunaief
Intracellular retinal iron accumulation has been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of irreversible blindness among individuals over the age of 50. Ceruloplasmin/hephaestin double knockout mice (Cp/Heph DKO) and hepcidin knockout mice (Hepc KO) accumulate retinal iron and model some features of AMD. Two canonical pathways govern cellular iron import - transferrin-bound iron import and non-transferrin bound iron import. In Cp/Heph DKO and Hepc KO iron-loaded retinas, transferrin-bound iron import is downregulated...
January 2, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28056406/the-impact-of-maternal-factors-on-the-association-between-temperature-and-preterm-delivery
#11
Rupa Basu, Hong Chen, De-Kun Li, Lyndsay A Avalos
BACKGROUND: Few studies have examined maternal modifiers of temperature and adverse birth outcomes because of lack of data. We assessed the relationship between apparent temperature, preterm delivery (PTD) and maternal demographics, medical and mental health conditions, and behaviors. METHODS: A time-stratified case-crossover analysis was conducted using 14,466 women who had a PTD (20 to less than 37 gestational weeks) from 1995 to 2009 using medical records from a large health maintenance organization in Northern California...
January 2, 2017: Environmental Research
https://www.readbyqxmd.com/read/28052867/how-consumer-physical-activity-monitors-could-transform-human-physiology-research
#12
Stephen P Wright, Tyish S Hall Brown, Scott R Collier, Kathryn Sandberg
Sedentary lifestyle and lack of physical activity are well-established risk factors for chronic disease and adverse health outcomes. Thus there is enormous interest in measuring physical activity in biomedical research. Many consumer physical activity monitors, including Basis® Health Tracker, BodyMedia® Fit, DirectLife®, Fitbit® Flex, Fitbit One, Fitbit Zip, Garmin® Vivofit, Jawbone® UP, MisFit® Shine, Nike® FuelBand, Polar® Loop, Withings® Pulse O2, and others have accuracies similar to that of research-grade physical activity monitors for measuring steps...
January 4, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28045337/transcript-analysis-in-two-alfalfa-salt-tolerance-selected-breeding-populations-relative-to-a-non-tolerant-population
#13
M Y Gruber, J Xia, M Yu, H Steppuhn, K Wall, D Messer, A G Sharpe, S N Acharya, D S Wishart, D Johnson, D R Miller, A Taheri
With the growing limitations on arable land, alfalfa (a widely cultivated, low-input forage) is now being selected to extend cultivation into saline lands for low-cost biofeedstock purposes. Here, minerals and transcriptome profiles were compared between two new salinity-tolerant North American alfalfa breeding populations and a more salinity-sensitive western Canadian alfalfa population grown under hydroponic saline conditions. All three populations accumulated two-fold higher sodium in roots than shoots as a function of increased electrical conductivity...
October 7, 2016: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28039114/model-based-calculating-tool-for-pollen-mediated-gene-flow-frequencies-in-plants
#14
Wang Lei, Lu Bao-Rong
The potential social-economic and environmental impacts caused by transgene flow from genetically engineered (GE) crops have stimulated worldwide biosafety concerns. To determine transgene flow frequencies resulted from pollination is the first critical step for assessing such impacts, in addition to the determination of transgene expression and fitness in crop-wild hybrid descendants. Two methods are commonly used to estimate pollen-mediated gene flow (PMGF) frequencies: field experimenting and mathematical modeling...
December 30, 2016: AoB Plants
https://www.readbyqxmd.com/read/28038389/adherence-to-antiepileptic-drugs-among-diverse-older-americans-on-part-d-medicare
#15
Kendra Piper, Joshua Richman, Edward Faught, Roy Martin, Ellen Funkhouser, Jerzy P Szaflarski, Chen Dai, Lucia Juarez, Maria Pisu
INTRODUCTION: Older minority groups are more likely to have poor AED adherence. We describe adherence to antiepileptic drugs (AEDs) among older Americans with epilepsy. METHODS: In retrospective analyses of 2008-2010 Medicare claims for a 5% random sample of beneficiaries augmented by minority representation, epilepsy cases in 2009 were those with ≥1 claim with ICD-9345.x or ≥2 with 780.3x, and ≥1 AED. New-onset cases had no such claims or AEDs in the year before the 2009 index event...
December 27, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28030476/socioeconomic-disparities-in-mortality-among-women-with-incident-breast-cancer-before-and-after-implementation-of-medicare-part-d
#16
Ann B Nattinger, Erica M Wozniak, Emily L McGinley, Jianing Li, Purushottam Laud, Liliana E Pezzin
BACKGROUND: Breast cancer patients exhibit survival disparities based on socioeconomic status (SES). Disparities may be attributable to access to expensive oral endocrine agents. OBJECTIVES: Define recent socioeconomic disparities in breast cancer survival and determine whether these improved after implementation of the Medicare Part D program. DESIGN: Difference-in-difference natural experiment of women diagnosed and treated before or after implementation of Medicare Part D...
December 27, 2016: Medical Care
https://www.readbyqxmd.com/read/28028241/abscisic-acid-signaling-is-controlled-by-a-branched1-hd-zip-i-cascade-in-arabidopsis-axillary-buds
#17
Eduardo González-Grandío, Alice Pajoro, José M Franco-Zorrilla, Carlos Tarancón, Richard G H Immink, Pilar Cubas
Shoot-branching patterns determine key aspects of plant life and are important targets for crop breeding. However, we are still largely ignorant of the genetic networks controlling locally the most important decision during branch development: whether the axillary bud, or branch primordium, grows out to give a lateral shoot or remains dormant. Here we show that, inside the buds, the TEOSINTE BRANCHED1, CYCLOIDEA, PCF (TCP) transcription factor BRANCHED1 (BRC1) binds to and positively regulates the transcription of three related Homeodomain leucine zipper protein (HD-ZIP)-encoding genes: HOMEOBOX PROTEIN 21 (HB21), HOMEOBOX PROTEIN 40 (HB40), and HOMEOBOX PROTEIN 53 (HB53)...
December 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28025828/prognostic-parameters-and-outcome-after-re-irradiation-for-progressive-glioblastoma
#18
K Zwirner, F Paulsen, J Schittenhelm, C Borchers, M Skardelly, D Zips, F Eckert
OBJECTIVES: In progressive glioblastoma, salvage treatment remains unstandardized, response is highly variable, and detailed analysis of individual approaches is mandatory. Re-irradiation is an established option in the therapy of progressive glioblastoma. Thus, we analysed outcome and prognostic parameters of patients with re-irradiated glioblastoma treated at our institution since 1998. MATERIALS AND METHODS: In a total of 51 patients, clinical and treatment parameters were collected and analysed retrospectively...
December 26, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28024420/assessing-the-correlation-between-physical-activity-and-quality-of-life-in-advanced-lung-cancer
#19
Brett C Bade, Mary C Brooks, Sloan B Nietert, Ansley Ulmer, D David Thomas, Paul J Nietert, JoAnn B Scott, Gerard A Silvestri
BACKGROUND AND OBJECTIVE: Increasing physical activity (PA) is safe and beneficial in lung cancer (LC) patients. Advanced-stage LC patients are under-studied and have worse symptoms and quality of life (QoL). We evaluated the feasibility of monitoring step count in advanced LC as well as potential correlations between PA and QoL. METHODS: This is a prospective, observational study of 39 consecutive patients with advanced-stage LC. Daily step count over 1 week (via Fitbit Zip), QoL, dyspnea, and depression scores were collected...
December 1, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28017810/access-to-quaternary-care-surgery-implications-for-accountable-care-organizations
#20
J Hunter Mehaffey, Robert B Hawkins, Matthew G Mullen, Max O Meneveau, Bruce Schirmer, Irving L Kron, R Scott Jones, Peter T Hallowell
BACKGROUND: Accountable Care Organizations (ACO) attempt to provide the most efficient and effective care to patients within a region. We hypothesize that patients who undergo surgery closer to home have improved survival due to proximity of preoperative and post-discharge care. STUDY DESIGN: All (17,582) institutional American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) patients with a documented zip code and predicted risk who underwent surgery at our institution (2005-2014) were evaluated...
December 22, 2016: Journal of the American College of Surgeons
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