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https://www.readbyqxmd.com/read/28817781/availability-and-variation-of-publicly-reported-prescription-drug-prices
#1
Jeffrey T Kullgren, Joel E Segel, Timothy A Peterson, A Mark Fendrick, Simone Singh
OBJECTIVES: To examine how often retail prices for prescription drugs are available on state public reporting websites, the variability of these reported prices, and zip code characteristics associated with greater price variation. STUDY DESIGN: Searches of state government-operated websites in Michigan, Missouri, New York, and Pennsylvania for retail prices for Advair Diskus (250/50 fluticasone propionate/salmeterol), Lyrica (pregabalin 50 mg), Nasonex (mometasone 50 mcg nasal spray), Spiriva (tiotropium 18 mcg cp-handihaler), Zetia (ezetimibe 10 mg), atorvastatin 20 mg, and metoprolol 50 mg...
July 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28817779/the-price-may-not-be-right-the-value-of-comparison-shopping-for-prescription-drugs
#2
Sanjay Arora, Neeraj Sood, Sophie Terp, Geoffrey Joyce
OBJECTIVES: To measure variations in drug prices across and within zip codes that may reveal simple strategies to improve patients' access to prescribed medications. STUDY DESIGN: We compared drug prices at different types of pharmacies across and within local markets. In-store prices were compared with a Web-based service providing discount coupons for prescription medications. Prices were collected for 2 generic antibiotics because most patients have limited experience with them and are less likely to know the price ranges for them...
July 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28815148/spatio-temporal-analysis-for-new-york-state-sparcs-data
#3
Xin Chen, Yu Wang, Elinor Schoenfeld, Mary Saltz, Joel Saltz, Fusheng Wang
Increased accessibility of health data provides unique opportunities to discover spatio-temporal patterns of diseases. For example, New York State SPARCS (Statewide Planning and Research Cooperative System) data collects patient level detail on patient demographics, diagnoses, services, and charges for each hospital inpatient stay and outpatient visit. Such data also provides home addresses for each patient. This paper presents our preliminary work on spatial, temporal, and spatial-temporal analysis of disease patterns for New York State using SPARCS data...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28813753/pre-guideline-trends-associated-with-chest-radiograph-usage-for-pediatric-community-acquired-pneumonia-in-emergency-department-settings
#4
Eric W Jones, Benjamin Meyer, Aaron M Berg, Benson S Hsu
BACKGROUND: Health care spending in the U.S. totaled $3 trillion in 2014 and continues to increase rapidly. Minimizing waste through clinical guidelines is a promising strategy to reduce spending without compromising patient care. In 2011, clinical guidelines recommended against the use of chest X-ray (CXR) for diagnosis of community-acquired pneumonia (CAP) in pediatric ambulatory settings. However, use of CXR has not changed post-guideline. Thus, understanding the drivers of CXR utilization prior to guideline implementation could improve guideline adherence...
May 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28810077/synthesis-of-ladder-polymers-developments-challenges-and-opportunities
#5
Yew Chin Teo, Holden W H Lai, Yan Xia
Ladder polymers are unique in that their backbones consist of fused rings with adjacent rings having two or more atoms in common. The restriction of bond rotations in rigid ladder polymers greatly limits their conformational freedom, leading to many intriguing and unique properties. As a non-traditional type of polymers, rigid ladder polymers are of great fundamental interest and technical importance as advanced materials for applications such as membrane gas separation and organic electronics. Ladder polymers can be divided into non-conjugated (with kinked conformations) and conjugated (with planar conformations) structures...
August 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28808127/the-components-of-the-unique-zur-regulon-of-cupriavidus-metallidurans-mediate-cytoplasmic-zinc-handling
#6
Lucy Bütof, Christopher Schmidt-Vogler, Martin Herzberg, Cornelia Große, Dietrich H Nies
Zinc is an essential trace element and at the same time it is toxic at high concentrations. In the beta-proteobacterium Cupriavidus metallidurans the highly efficient removal of surplus zinc from the periplasm is responsible for its outstanding metal resistance. Rather than having a typical Zur-dependent, high-affinity ATP-binding cassette transporter of the ABC protein superfamily for zinc uptake at low concentrations, C. metallidurans instead has the secondary zinc importer ZupT of the ZRT/IRT (ZIP) family...
August 14, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28806232/assessment-of-medical-surgical-patients-perception-of-hospital-noises-and-reported-ability-to-rest
#7
Christine L Locke, Diana S Pope
OBJECTIVES: The purpose was to determine if an enhanced privacy curtain (1) impacted ability to rest while hospitalized in the acute care setting and (2) improved patient satisfaction associated with environmental noise. METHODS: The project evaluated a privacy curtain designed to increase speech privacy and intelligibility and reduce reverberation time (echo). The curtain was similar to the existing privacy curtain with 2 exceptions: the curtain panel had pocket inserts that absorbed sound, and curtain panels could be zipped together to reduce sound transmission through gaps...
September 2017: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/28805249/a-non-dna-binding-activity-for-the-athb4-transcription-factor-in-the-control-of-vegetation-proximity
#8
Marçal Gallemí, Maria Jose Molina-Contreras, Sandi Paulišić, Mercè Salla-Martret, Céline Sorin, Marta Godoy, Jose Manuel Franco-Zorrilla, Roberto Solano, Jaime F Martínez-García
In plants, perception of vegetation proximity by phytochrome photoreceptors activates a transcriptional network that implements a set of responses to adapt to plant competition, including elongation of stems or hypocotyls. In Arabidopsis thaliana, the homeodomain-leucine zipper (HD-Zip) transcription factor ARABIDOPSIS THALIANA HOMEOBOX 4 (ATHB4) regulates this and other responses, such as leaf polarity. To better understand the shade regulatory transcriptional network, we have carried out structure-function analyses of ATHB4 by overexpressing a series of truncated and mutated forms and analyzing three different responses: hypocotyl response to shade, transcriptional activity and leaf polarity...
August 14, 2017: New Phytologist
https://www.readbyqxmd.com/read/28802746/is-it-who-you-are-or-where-you-live-residential-segregation-and-racial-gaps-in-childhood-asthma
#9
Diane Alexander, Janet Currie
Higher asthma rates are one of the more obvious ways that health inequalities between African American and other children are manifested beginning in early childhood. In 2010, black asthma rates were double non-black rates. Some but not all of this difference can be explained by factors such as a higher incidence of low birth weight (LBW) among blacks; however, even conditional on LBW, blacks have a higher incidence of asthma than others. Using a unique data set based on the health records of all children born in New Jersey between 2006 and 2010, we show that when we split the data by whether or not children live in a "black" zip code, this racial difference in the incidence of asthma among LBW children entirely disappears...
July 25, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/28802410/evaluation-of-24-locus-miru-vntr-genotyping-in-mycobacterium-tuberculosis-cluster-investigations-in-four-jurisdictions-in-the-united-states-2006-2010
#10
Larry D Teeter, J Steven Kammerer, Smita Ghosh, Duc T M Nguyen, Padmaja Vempaty, Jane Tapia, Roque Miramontes, Wendy A Cronin, Edward A Graviss
The U.S. Centers for Disease Control and Prevention (CDC) uses a combination of spacer oligonucleotide typing (spoligotyping) and mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR) analyses as part of the National TB Genotyping Service (NTGS). The NTGS expansion from 12-locus MIRU-VNTR (MIRU12) to 24-locus MIRU-VNTR (MIRU24) in 2009 enhanced the ability to discriminate Mycobacterium tuberculosis strains. In the current study, we investigated the MIRU24 concordance among epidemiologic-linked tuberculosis (TB) patients in four U...
September 2017: Tuberculosis
https://www.readbyqxmd.com/read/28801619/repetitive-motor-cortex-stimulation-reinforces-the-pain-modulation-circuits-of-peripheral-neuropathic-pain
#11
Myeounghoon Cha, Sun Woo Um, Minjee Kwon, Taick Sang Nam, Bae Hwan Lee
Recent evidence indicates that motor cortex stimulation (MCS) is a potentially effective treatment for chronic neuropathic pain. However, the neural mechanisms underlying the attenuated hyperalgesia after MCS are not completely understood. In this study, we investigated the neural mechanism of the effects of MCS using an animal model of neuropathic pain. After 10 daily sessions of MCS, repetitive MCS reduced mechanical allodynia and contributed to neuronal changes in the anterior cingulate cortex (ACC). Interestingly, inhibition of protein kinase M zeta (PKMζ), a regulator of synaptic plasticity, in the ACC blocked the effects of repetitive MCS...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801304/how-accurate-is-your-activity-tracker-a-comparative-study-of-step-counts-in-low-intensity-physical-activities
#12
Parastoo Alinia, Chris Cain, Ramin Fallahzadeh, Armin Shahrokni, Diane Cook, Hassan Ghasemzadeh
BACKGROUND: As commercially available activity trackers are being utilized in clinical trials, the research community remains uncertain about reliability of the trackers, particularly in studies that involve walking aids and low-intensity activities. While these trackers have been tested for reliability during walking and running activities, there has been limited research on validating them during low-intensity activities and walking with assistive tools. OBJECTIVE: The aim of this study was to (1) determine the accuracy of 3 Fitbit devices (ie, Zip, One, and Flex) at different wearing positions (ie, pants pocket, chest, and wrist) during walking at 3 different speeds, 2...
August 11, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28797879/using-a-non-invasive-secure-skin-closure-following-total-knee-arthroplasty-leads-to-fewer-wound-complications-and-no-patient-home-care-visits-compared-to-surgical-staples
#13
Alberto V Carli, Sara Spiro, Brian T Barlow, Steven B Haas
BACKGROUND: Superficial wound complications occur in up to 10% of total knee arthroplasty (TKA) procedures and have been associated with periprosthetic joint infection. The ideal material for TKA closure should offer: 1) fast intraoperative application, 2) minimal wound complications and 3) removable by patients without assistance. We evaluated a novel, non-invasive, removable skin closure system for TKA to determine its effect on wound complications. METHODS: We prospectively evaluated 221 consecutive TKA patients who received skin closure using a non-invasive zipper-like system ('Zip'; Zip 16 Surgical Skin Closure System; Zipline Medical)...
August 7, 2017: Knee
https://www.readbyqxmd.com/read/28795096/dataset-of-anomalies-and-malicious-acts-in-a-cyber-physical-subsystem
#14
Pedro Merino Laso, David Brosset, John Puentes
This article presents a dataset produced to investigate how data and information quality estimations enable to detect aNomalies and malicious acts in cyber-physical systems. Data were acquired making use of a cyber-physical subsystem consisting of liquid containers for fuel or water, along with its automated control and data acquisition infrastructure. Described data consist of temporal series representing five operational scenarios - Normal, aNomalies, breakdown, sabotages, and cyber-attacks - corresponding to 15 different real situations...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28792886/mediating-effects-of-social-support-and-internalized-homonegativity-on-the-association-between-population-density-and-mental-health-among-gay-and-bisexual-men
#15
Demetria N Cain, Chloe Mirzayi, H Jonathon Rendina, Ana Ventuneac, Christian Grov, Jeffrey T Parsons
PURPOSE: Depression negatively impacts the health and well-being of gay and bisexual men (GBM). However, little is known about the contexts in which rural GBM live relative to those living in urban areas and their overall mental health. The aim of this study was to examine associations between population density and depressive symptoms and the role of internalized homonegativity and social support as potential mediators. METHODS: A nationally representative sample of 1071 GBM (mean age = 40...
August 9, 2017: LGBT Health
https://www.readbyqxmd.com/read/28789804/all-cause-hospital-admissions-among-older-adults-after-a-natural-disaster
#16
Sue Anne Bell, Mahshid Abir, HwaJung Choi, Colin Cooke, Theodore Iwashyna
STUDY OBJECTIVE: We characterize hospital admissions among older adults for any cause in the 30 days after a significant natural disaster in the United States. The main outcome was all-cause hospital admissions in the 30 days after natural disaster. Separate analyses were conducted to examine all-cause hospital admissions excluding the 72 hours after the disaster, ICU admissions, all-cause inhospital mortality, and admissions by state. METHODS: A self-controlled case series analysis using the 2011 Medicare Provider and Analysis Review was conducted to examine exposure to natural disaster by elderly adults located in zip codes affected by tornadoes during the 2011 southeastern superstorm...
August 5, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28789614/comparative-transcriptome-analysis-reveals-key-cadmium-transport-related-genes-in-roots-of-two-pak-choi-brassica-rapa-l-ssp-chinensis-cultivars
#17
Rugang Yu, Dan Li, Xueling Du, Shenglan Xia, Caifeng Liu, Gangrong Shi
BACKGROUND: Cadmium translocation from roots to shoots is a complex biological process that is controlled by gene regulatory networks. Pak choi exhibits wide cultivar variations in Cd accumulation. However, the molecular mechanism involved in cadmium translocation and accumulation is still unclear. To isolate differentially expressed genes (DEGs) involved in transporter-mediated regulatory mechanisms of Cd translocation in two contrasting pak choi cultivars, Baiyewuyueman (B, high Cd accumulator) and Kuishan'aijiaoheiye (K, low Cd accumulator), eight cDNA libraries from the roots of two cultivars were constructed and sequenced by RNA-sequencing...
August 8, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28780137/the-effect-of-drinking-water-contaminated-with-perfluoroalkyl-substances-on-a-10-year-longitudinal-trend-of-plasma-levels-in-an-elderly-uppsala-cohort
#18
Jordan Stubleski, Samira Salihovic, P Monica Lind, Lars Lind, Linda Dunder, Philip McCleaf, Karin Eurén, Lutz Ahrens, Magnus Svartengren, Bert van Bavel, Anna Kärrman
BACKGROUND: In 2012, drinking water contaminated with per- and polyfluoroalkyl substances (PFASs), foremost perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) at levels over 20ng/L and 40ng/L, respectively, was confirmed in Uppsala, Sweden. OBJECTIVES: We assessed how a longitudinally sampled cohort's temporal trend in PFAS plasma concentration was influenced by their residential location and determined the plausible association or disparity between the PFASs detected in the drinking water and the trend in the study cohort...
August 3, 2017: Environmental Research
https://www.readbyqxmd.com/read/28780100/technical-note-pagell-v-1-5-a-flexible-parametric-program-for-the-bayesian-analysis-of-longevity-data-within-the-context-of-animal-breeding
#19
J Casellas, L C Brito
This technical note presents the program PaGELL v.1.5 (Parametric Genetic Evaluation of Lifespan in Livestock), a flexible software program to analyze (right-censored) longevity data in livestock populations, with a special emphasis on the genetic evaluation of the breeding stock. This software relies on a parametric generalization of the proportional hazard model; more specifically, the baseline hazard function follows a Weibull process and flexibility is gained by including an additional time-dependent effect with the number of change points defined by the user...
August 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28777710/step-count-accuracy-and-reliability-of-two-activity-tracking-devices-in-people-after-stroke
#20
Samuel D Schaffer, Simon D Holzapfel, George Fulk, Pamela Rogers Bosch
BACKGROUND/PURPOSE: The increasing popularity of activity tracking devices presents an opportunity to monitor physical activity in patients after stroke. We sought to determine the reliability and accuracy of the Garmin Vivofit and Fitbit Zip for adults after stroke. METHODS: Twenty-four participants with stroke-induced hemiparesis wore a Fitbit Zip on the nonparetic hip and Garmin Vivofits on both wrists during a 6-minute walk test to determine the accuracy of the devices against video-determined step counts...
August 4, 2017: Physiotherapy Theory and Practice
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