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https://www.readbyqxmd.com/read/28528463/facebook-advertising-to-recruit-young-urban-women-into-an-hiv-prevention-clinical-trial
#1
Rachel Jones, Lorraine J Lacroix, Eloni Porcher
Advertising via Facebook to elicit involvement in clinical trials has demonstrated promise in expanding geographic reach while maintaining confidentiality. The purpose of this study is to evaluate Facebook advertising to reach at-risk, predominately African American or Black women in higher HIV prevalence communities for an HIV prevention clinical trial, and to compare baseline characteristics to those recruited on-the-ground. Maintaining confidentiality and the practical aspects of creating and posting ads on Facebook are described...
May 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28527331/analysis-of-zip-zrt-irt-related-protein-transporter-gene-expression-in-murine-neural-stem-progenitor-cells
#2
Mayu Nishikawa, Hideki Mori, Masayuki Hara
Zinc plays important roles for brain development. Zrt-, Irt-related protein (ZIP) is a major transporter family to regulate the intracellular zinc levels. Neural stem/progenitor cells (NSPCs) are more sensitive than their differentiated progeny (neural/glial cells) to zinc in vitro (Nishikawa et al., 2015). We analyzed relative gene expression of 14 different ZIPs in murine NSPCs and differentiated cells by real-time polymerase chain reaction technique. Expression of Zip4 and that of Zip12 drastically increased, while that of Zip8 clearly decreased after differentiation of NSPCs...
May 11, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28521576/rethinking-the-foam-cosmesis-for-people-with-lower-limb-absence
#3
Nicola Cairns, Jonathan Corney, Kevin Murray, Karena Moore-Millar, Gillian D Hatcher, Saeed Zahedi, Richard Bradbury, Joe McCarthy
BACKGROUND AND AIM: A recent survey of people with lower limb absence revealed that patients' satisfaction with their foam cosmesis is lower than desired. The aim of this project was to improve the lifelike appearance, functionality and durability of the cosmesis through a user-centred design methodology. TECHNIQUE: Concept development and prototyping led to a new cosmesis design which features a cut-out located at the knee, inserted with an artificial patella made of a more rigid foam...
May 1, 2017: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/28520876/geographic-information-systems-mapping-of-diabetic-retinopathy-in-an-ocular-telemedicine-network
#4
Pooja D Jani, Lauren Forbes, Philip McDaniel, Anthony Viera, Seema Garg
Importance: Minimal information exists on the use of geographic information systems mapping for visualizing access barriers to eye care for patients with diabetes. Objective: To use geographic information systems mapping techniques to visualize (1) the locations of patients participating in the North Carolina Diabetic Retinopathy Telemedicine Network, (2) the locations of primary care clinicians and ophthalmologists across the state, and (3) the travel times associated with traveling to the 5 primary care clinics in our study...
May 18, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28520589/distance-to-specialist-care-and-disease-outcomes-in-inflammatory-bowel-disease
#5
Nienke Z Borren, Grace Conway, William Tan, Elizabeth Andrews, John J Garber, Vijay Yajnik, Ashwin N Ananthakrishnan
BACKGROUND: Optimal treatment of inflammatory bowel disease (IBD) requires specialized health care. Patients frequently travel long distances to obtain care for IBD, which may hinder regular care and affect outcomes adversely. METHODS: This study included patients with established Crohn's disease or ulcerative colitis receiving care at a single referral center between January 2005 and August 2016. Distance to our health care center from the zip code of residence was determined for each patient and classified into quartiles...
May 16, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28515164/mrna-levels-of-placental-iron-and-zinc-transporter-genes-are-upregulated-in-gambian-women-with-low-iron-and-zinc-status
#6
Modou Lamin Jobarteh, Harry J McArdle, Grietje Holtrop, Ebrima A Sise, Andrew M Prentice, Sophie E Moore
Background: The role of the placenta in regulating micronutrient transport in response to maternal status is poorly understood.Objective: We investigated the effect of prenatal nutritional supplementation on the regulation of placental iron and zinc transport.Methods: In a randomized trial in rural Gambia [ENID (Early Nutrition and Immune Development)], pregnant women were allocated to 1 of 4 nutritional intervention arms: 1) iron and folic acid (FeFol) tablets (FeFol group); 2) multiple micronutrient (MMN) tablets (MMN group); 3) protein energy (PE) as a lipid-based nutrient supplement (LNS; PE group); and 4) PE and MMN (PE+MMN group) as LNS...
May 17, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28507755/ethnic-variations-in-the-occurrence-of-colonic-neoplasms
#7
Amnon Sonnenberg, Kevin O Turner, Robert M Genta
BACKGROUND AND AIMS: With the exception of African Americans and Hispanics, few studies have dealt with the influence of other types of ethnicity on the prevalence of colon polyps and colorectal cancer. The present study was undertaken to compare the ethnic and socioeconomic distributions of colonic neoplasms among different ethnic groups in the United States. METHODS: A total of 813,057 patients, who underwent colonoscopy during 2008-2014, were recruited from an electronic database of histopathology reports (Miraca Life Sciences) for a cross-sectional study...
April 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28506545/travel-for-abortion-services-in-alabama-and-delays-obtaining-care
#8
Kari White, Janet M Turan, Daniel Grossman
BACKGROUND: In 2013, Alabama required women seeking abortion to have a consultation visit followed by a 24-hour waiting period. These requirements may adversely affect return for timely care among those traveling long distances for services. METHODS: Using de-identified billing data from two Alabama clinics for all abortion encounters in 2013, we calculated the distance traveled from women's residential zip code and the number of days between their in-person consultation and procedure visits...
May 12, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28498500/socioeconomic-disparities-and-comorbidities-not-race-affect-salivary-gland-malignancy-survival-outcomes
#9
Ayaka J Iwata, Amy M Williams, Andrew R Taylor, Steven S Chang
OBJECTIVES/HYPOTHESIS: This study sought to determine whether comorbidities, race, and socioeconomic factors affect 5- and 10-year survival outcomes for patients with salivary gland malignancies treated at a single large academic institution with a large African American population. STUDY DESIGN: A retrospective cohort study was performed of all patients with salivary gland malignancies, from 1990 to 2015, at a large academic medical center. METHODS: Standard statistical analysis was performed using Kaplan-Meier survival curve analysis and Cox proportional hazard models...
May 12, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28492949/the-role-of-skin-care-in-optimizing-treatment-of-acne-and-rosacea
#10
C Zip
A triad approach to the treatment of acne and rosacea has been recommended. This integrated management approach includes patient education, selection of therapeutic agents, and initiation of an appropriate skin care regime. Proper skin care in patients undergoing treatment of both acne and rosacea includes use of products formulated for sensitive skin that cleanse, moisturize and photoprotect the skin. Both acne and rosacea are associated with epidermal barrier dysfunction, which can be mitigated by suitable skin care practices...
May 2017: Skin Therapy Letter
https://www.readbyqxmd.com/read/28492449/measuring-subcounty-differences-in-population-health-using-hospital-and-census-derived-data-sets-the-missouri-zip-health-rankings-project
#11
Elna Nagasako, Brian Waterman, Mathew Reidhead, Min Lian, Sarah Gehlert
CONTEXT: Measures of population health at the subcounty level are needed to identify areas for focused interventions and to support local health improvement activities. OBJECTIVE: To extend the County Health Rankings population health measurement model to the ZIP code level using widely available hospital and census-derived data sources. DESIGN: Retrospective administrative data study. SETTING: Missouri. POPULATION: Missouri FY 2012-2014 hospital inpatient, outpatient, and emergency department discharge encounters (N = 36 176 377) and 2015 Nielsen data...
May 10, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28490521/survival-in-women-versus-men-following-implantation-of-pacemakers-defibrillators-and-cardiac-resynchronization-therapy-devices-in-a-large-nationwide-cohort
#12
Niraj Varma, Suneet Mittal, Julie B Prillinger, Jeff Snell, Nirav Dalal, Jonathan P Piccini
BACKGROUND: Whether outcomes differ between sexes following treatment with pacemakers (PM), implantable cardioverter defibrillators, and cardiac resynchronization therapy (CRT) devices is unclear. METHODS AND RESULTS: Consecutive US patients with newly implanted PM, implantable cardioverter defibrillators, and CRT devices from a large remote monitoring database between 2008 and 2011 were included in this observational cohort study. Sex-specific all-cause survival postimplant was compared within each device type using a multivariable Cox proportional hazards model, stratified on age and adjusted for remote monitoring utilization and ZIP-based socioeconomic variables...
May 10, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28486687/analysis-of-national-rates-cost-and-sources-of-cost-variation-in-adult-spinal-deformity
#13
Corinna C Zygourakis, Caterina Y Liu, Malla Keefe, Christopher Moriates, John Ratliff, R Adams Dudley, Ralph Gonzales, Praveen V Mummaneni, Christopher P Ames
BACKGROUND: Several studies suggest significant variation in cost for spine surgery, but there has been little research in this area for spinal deformity. OBJECTIVE: To determine the utilization, cost, and factors contributing to cost for spinal deformity surgery. METHODS: The cohort comprised 55 599 adults who underwent spinal deformity fusion in the 2001 to 2013 National Inpatient Sample database. Patient variables included age, gender, insurance, median income of zip code, county population, severity of illness, mortality risk, number of comorbidities, length of stay, elective vs nonelective case...
May 9, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28483930/comparison-of-four-fitbit-and-jawbone-activity-monitors-with-a-research-grade-actigraph-accelerometer-for-estimating-physical-activity-and-energy-expenditure
#14
Mary T Imboden, Michael B Nelson, Leonard A Kaminsky, Alexander Hk Montoye
BACKGROUND/AIM: Consumer-based physical activity (PA) monitors have become popular tools to track PA behaviours. Currently, little is known about the validity of the measurements provided by consumer monitors. We aimed to compare measures of steps, energy expenditure (EE) and active minutes of four consumer monitors with one research-grade accelerometer within a semistructured protocol. METHODS: Thirty men and women (18-80 years old) wore Fitbit One (worn at the waist), Fitbit Zip (waist), Fitbit Flex (wrist), Jawbone UP24 (wrist) and one waist-worn research-grade accelerometer (ActiGraph) while participating in an 80 min protocol...
May 8, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28481298/vulnerability-and-diversity-aware-anonymization-of-personally-identifiable-information-for-improving-user-privacy-and-utility-of-publishing-data
#15
Abdul Majeed, Farman Ullah, Sungchang Lee
Personally identifiable information (PII) affects individual privacy because PII combinations may yield unique identifications in published data. User PII such as age, race, gender, and zip code contain private information that may assist an adversary in determining the user to whom such information relates. Each item of user PII reveals identity differently, and some types of PII are highly identity vulnerable. More vulnerable types of PII enable unique identification more easily, and their presence in published data increases privacy risks...
May 8, 2017: Sensors
https://www.readbyqxmd.com/read/28480996/the-pd-1-pd-l1-axis-and-human-papilloma-virus-in-patients-with-head-and-neck-cancer-after-adjuvant-chemoradiotherapy-a-multicentre-study-of-the-german-cancer-consortium-radiation-oncology-group-dktk-rog
#16
Panagiotis Balermpas, Franz Rödel, Mechthild Krause, Annett Linge, Fabian Lohaus, Michael Baumann, Inge Tinhofer, Volker Budach, Ali Sak, Martin Stuschke, Eleni Gkika, Anca-Ligia Grosu, Amir Abdollahi, Jürgen Debus, Stefan Stangl, Ute Ganswindt, Claus Belka, Steffi Pigorsch, Gabriele Multhoff, Stephanie E Combs, Stefan Welz, Daniel Zips, Su Yin Lim, Claus Rödel, Emmanouil Fokas
We examined the prognostic role of PD-1+ and CD8+ tumor infiltrating lymphocytes (TILs), and PD-L1+ cells in patients with squamous cell carcinoma of the head and neck (SCCHN) treated with surgery and postoperative chemoradiotherapy (CRT). FFPE samples from 161 patients were immunohistochemically stained for PD-1, CD8 and PD-L1. The immune marker expression was correlated with clinicopathologic characteristics, and overall survival (OS), local progression-free survival (LPFS) and distant metastases free-survival (DMFS), also in the context of HPV16 DNA/p16 status...
May 8, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28479192/predictors-of-emergency-department-use-in-children-with-persistent-asthma-in-metropolitan-atlanta-georgia
#17
Jeffery M Franklin, Jocelyn R Grunwell, Alice C Bruce, Robin C Smith, Anne M Fitzpatrick
BACKGROUND: Racial disparities are evident among children with asthma in the United States, with non-Hispanic black children at particularly high risk for poor asthma outcomes, including frequent emergency department (ED) use for asthma exacerbations. OBJECTIVE: To compare asthma features in non-Hispanic black vs white children in Atlanta, Georgia, and determine what clinical features predict future ED use for asthma. METHODS: Self-reported black and white children 6 to 17 years of age with persistent asthma treated with controller medications completed medical history questionnaires, lung function testing, aeroallergen sensitization testing, and venipuncture...
May 4, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28479083/zip9-a-novel-membrane-androgen-receptor-and-zinc-transporter-protein
#18
Peter Thomas, Aubrey Converse, Håkan A Berg
Rapid, androgen actions initiated at the cell surface have been reported in a variety of vertebrate cells, including several macrophage and prostate cancer cell lines that lack the nuclear androgen receptor. However, until recently the identity of the novel membrane androgen receptor (mAR) mediating these nonclassical androgen actions remained unknown. In 2014, a novel mAR unrelated to nuclear androgen receptors was identified in Atlantic croaker ovaries as the zinc transporter protein, ZIP9. ZIP9 is one of the 14 members of the ZIP (ZRT-and Irt-like Protein, SLC39A) family that regulates zinc homeostasis by transporting zinc across cell and organelle membranes into the cytoplasm...
May 4, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28476461/adding-social-determinant-data-changes-children-s-hospitals-readmissions-performance
#19
Marion R Sills, Matthew Hall, Gretchen J Cutler, Jeffrey D Colvin, Laura M Gottlieb, Michelle L Macy, Jessica L Bettenhausen, Rustin B Morse, Evan S Fieldston, Jean L Raphael, Katherine A Auger, Samir S Shah
OBJECTIVES: To determine whether social determinants of health (SDH) risk adjustment changes hospital-level performance on the 30-day Pediatric All-Condition Readmission (PACR) measure and improves fit and accuracy of discharge-level models. STUDY DESIGN: We performed a retrospective cohort study of all hospital discharges meeting criteria for the PACR from 47 hospitals in the Pediatric Health Information database from January to December 2014. We built four nested regression models by sequentially adding risk adjustment factors as follows: chronic condition indicators (CCIs); PACR patient factors (age and sex); electronic health record-derived SDH (race, ethnicity, payer), and zip code-linked SDH (families below poverty level, vacant housing units, adults without a high school diploma, single-parent households, median household income, unemployment rate)...
May 2, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28473189/a-tale-of-two-cancers-traveling-to-treat-pancreatic-and-thyroid-cancer
#20
Michael G White, Megan K Applewhite, Edwin L Kaplan, Peter Angelos, Dezheng Huo, Raymon H Grogan
BACKGROUND: Patients diagnosed with a malignancy must decide whether to travel for care at an academic center or receive treatment at a nearby hospital. Here we examine differences in demographics, treatment, and outcomes of those traveling to academic centers for their care vs those not traveling, as well as compare travel for an aggressive vs indolent malignancy. STUDY DESIGN: All patients with papillary thyroid carcinoma (PTC) or pancreatic ductal adenocarcinoma (PDAC) undergoing surgical resection and in the National Cancer Database were examined...
March 25, 2017: Journal of the American College of Surgeons
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