Jiayue Hong, Rebekah Garfolo, Sejal Kabre, Christian Humml, Viktorija Velanac, Clémence Roué, Brianna Beck, Haley Jeanette, Sarah Haslam, Martin Bach, Simar Arora, Jenica Acheta, Klaus-Armin Nave, Markus H Schwab, David Jourd'heuil, Yannick Poitelon, Sophie Belin
It is well established that axonal Neuregulin 1 type 3 (NRG1t3) regulates developmental myelin formation as well as EGR2-dependent gene activation and lipid synthesis. However, in peripheral neuropathy disease context, elevated axonal NRG1t3 improves remyelination and myelin sheath thickness without increasing Egr2 expression or activity, and without affecting the transcriptional activity of canonical myelination genes. Surprisingly, Pmp2, encoding for a myelin fatty acid binding protein, is the only gene whose expression increases in Schwann cells following overexpression of axonal NRG1t3...
February 5, 2024: Glia