keyword
MENU ▼
Read by QxMD icon Read
search

Neuroglia

keyword
https://www.readbyqxmd.com/read/29411894/melatonin-attenuated-retinal-neovascularization-and-neuroglial-dysfunction-by-inhibition-of-hif-1%C3%AE-vegf-pathway-in-oxygen-induced-retinopathy-mice
#1
REVIEW
Yue Xu, Xi Lu, Yaguang Hu, Boyu Yang, Ching-Kit Tsui, Shanshan Yu, Lin Lu, Xiaoling Liang
Retinopathy of prematurity (ROP) is a retinopathy characterized by retinal neovascularization (RNV) occurring in preterm infants treated with high concentrations of oxygen and may lead to blindness in severe cases. Currently, anti-VEGF therapy is a major treatment for ROP, but it is costly and may cause serious complications. The previous study has demonstrated that melatonin exerted neuroprotective effect against retinal ganglion cell death induced by hypoxia in neonatal rats. However, whether melatonin is anti-angiogenic and neuroglial protective in the progression of ROP remains unknown...
February 7, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29407440/thyroid-hormone-in-the-cns-contribution-of-neuron-glia-interaction
#2
Mami Noda
The endocrine system and the central nervous system (CNS) are intimately linked. Among hormones closely related to the nervous system, thyroid hormones (THs) are critical for the regulation of development and differentiation of neurons and neuroglia and hence for development and function of the CNS. T3 (3,3',5-triiodothyronine), an active form of TH, is important not only for neuronal development but also for differentiation of astrocytes and oligodendrocytes, and for microglial development. In adult brain, T3 affects glial morphology with sex- and age-dependent manner and therefore may affect their function, leading to influence on neuron-glia interaction...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29407366/low-but-not-high-dose-triptolide-controls-neuroinflammation-and-improves-behavioral-deficits-in-toxic-model-of-multiple-sclerosis-by-dampening-of-nf-%C3%AE%C2%BAb-activation-and-acceleration-of-intrinsic-myelin-repair
#3
Nima Sanadgol, Fereshteh Golab, Ali Mostafaie, Mehdi Mehdizadeh, Roghayeh Khalseh, Morteza Mahmoudi, Mohammad Abdollahi, Gelareh Vakilzadeh, Ghorban Taghizadeh, Mohammad Sharifzadeh
Cuprizone (Cup) is a copper chelating agent frequently used to study factors that affect oligodendrocytes (OLGs) death and acute demyelination. Triptolide (TP), a nuclear factor-kappaB (NF-κB) blocker, is a major bioactive component of Tripterygium wilfordii Hook f. (TWHf) with various therapeutic activities. In this study, we examined the effects of TP on neuroglia activation, inflammation, apoptosis, demyelination, and behavioral deficits in the Cup-induced toxic model of multiple sclerosis (MS). C57BL/6 J mice were fed with chow containing 0...
January 31, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29334986/bridging-pro-inflammatory-signals-synaptic-transmission-and-protection-in-spinal-explants-in-vitro
#4
M Medelin, V Giacco, A Aldinucci, G Castronovo, E Bonechi, A Sibilla, M Tanturli, M Torcia, L Ballerini, F Cozzolino, C Ballerini
Multiple sclerosis is characterized by tissue atrophy involving the brain and the spinal cord, where reactive inflammation contributes to the neurodegenerative processes. Recently, the presence of synapse alterations induced by the inflammatory responses was suggested by experimental and clinical observations, in experimental autoimmune encephalomyelitis mouse model and in patients, respectively. Further knowledge on the interplay between pro-inflammatory agents, neuroglia and synaptic dysfunction is crucial to the design of unconventional protective molecules...
January 15, 2018: Molecular Brain
https://www.readbyqxmd.com/read/29273287/rat-spinal-ganglia-in-assessment-of-protective-action-of-antioxidants-a-morphological-study
#5
Liudmyla M Sokurenko, M O Savchyna, V I Litus, R F Kaminsky, Yurii B Сhaikovsky
BACKGROUND AND OBJECTIVE: Mercury pollution is one of the most pressing environmental problems. Therefore, the impact of mercury on human body, the nervous system in particular, remains topical. The aim of the study was to identify the morphological characteristics of neurons and neuroglia in spinal ganglia of rats receiving antioxidants in the presence of small doses of mercury (II) chloride. MATERIALS AND METHODS: A total of 100 white Wistar rats were divided into 5 series (10 groups), with 10 animals in each group...
November 29, 2017: Medicina
https://www.readbyqxmd.com/read/29235729/conductive-tough-hydrogel-for-bioapplications
#6
Mohammad Javadi, Qi Gu, Sina Naficy, Syamak Farajikhah, Jeremy M Crook, Gordon G Wallace, Stephen Beirne, Simon E Moulton
Biocompatible conductive tough hydrogels represent a new class of advanced materials combining the properties of tough hydrogels and biocompatible conductors. Here, a simple method, to achieve a self-assembled tough elastomeric composite structure that is biocompatible, conductive, and with high flexibility, is reported. The hydrogel comprises polyether-based liner polyurethane (PU), poly(3,4-ethylenedioxythiophene) (PEDOT) doped with poly(4-styrenesulfonate) (PSS), and liquid crystal graphene oxide (LCGO)...
December 13, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29078046/dendritic-polyglycerol-sulfates-in-the-prevention-of-synaptic-loss-and-mechanism-of-action-on-glia
#7
Dusica Maysinger, Jeff Ji, Alexandre Moquin, Shireen Hossain, Mark A Hancock, Issan Zhang, Philip K Y Chang, Matthew Rigby, Madeleine Anthonisen, Peter Grutter, John C S Breitner, R Anne McKinney, Sabine Reimann, Rainer Haag, Gerhard Multhaup
Dendritic polyglycerols (dPG), particularly dendritic polyglycerol sulfates (dPGS), have been intensively studied due to their intrinsic anti-inflammatory activity. As related to brain pathologies involving neuroinflammation, the current study examined if dPG and dPGS can (i) regulate neuroglial activation, and (ii) normalize the morphology and function of excitatory postsynaptic dendritic spines adversely affected by the neurotoxic 42 amino acid amyloid-β (Aβ42) peptide of Alzheimer disease (AD). The exact role of neuroglia, such as microglia and astrocytes, remains controversial especially their positive and negative impact on inflammatory processes in AD...
October 27, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29046627/mecp2-deficiency-in-neuroglia-new-progress-in-the-pathogenesis-of-rett-syndrome
#8
REVIEW
Xu-Rui Jin, Xing-Shu Chen, Lan Xiao
Rett syndrome (RTT) is an X-linked neurodevelopmental disease predominantly caused by mutations of the methyl-CpG-binding protein 2 (MeCP2) gene. Generally, RTT has been attributed to neuron-centric dysfunction. However, increasing evidence has shown that glial abnormalities are also involved in the pathogenesis of RTT. Mice that are MeCP2-null specifically in glial cells showed similar behavioral and/or neuronal abnormalities as those found in MeCP2-null mice, a mouse model of RTT. MeCP2 deficiency in astrocytes impacts the expression of glial intermediate filament proteins such as fibrillary acidic protein (GFAP) and S100 and induces neuron toxicity by disturbing glutamate metabolism or enhancing microtubule instability...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28992428/inflammatory-mediators-in-mood-disorders-therapeutic-opportunities
#9
Madeline L Pfau, Caroline Ménard, Scott J Russo
Mood disorders such as depression are among the most prevalent psychiatric disorders in the United States, but they are inadequately treated in a substantial proportion of patients. Accordingly, neuropsychiatric research has pivoted from investigation of monoaminergic mechanisms to exploration of novel mediators, including the role of inflammatory processes. Subsets of mood disorder patients exhibit immune-related abnormalities, including elevated levels of proinflammatory cytokines, monocytes, and neutrophils in the peripheral circulation; dysregulation of neuroglia and blood-brain barrier function; and disruption of gut microbiota...
January 6, 2018: Annual Review of Pharmacology and Toxicology
https://www.readbyqxmd.com/read/28986877/analysis-of-functional-nmda-receptors-in-astrocytes
#10
Frank Kirchhoff
Neuronal N-methyl-D-aspartate (NMDA) receptors are well known for their pivotal role in memory formation. Originally, they were thought to be exclusive to neurons. However, numerous studies revealed their functional expression also on various types of glial cells in the nervous system. Here, the methodology how to study the physiology of NMDA receptors selectively on astrocytes will be described in detail. Astrocytes are the main class of neuroglia that control transmitter and ion homeostasis, which link cerebral blood flow and neuronal energy demands, but also affect synaptic transmission directly...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28973338/histologic-characterization-of-retina-neuroglia-modifications-in-diabetic-zucker-diabetic-fatty-rats
#11
Ivan Fernandez-Bueno, Robert Jones, Laura Soriano-Romaní, Antonio López-García, Orla Galvin, Sharon Cheetham, Yolanda Diebold
Purpose: The purpose of this study was to characterize retinal degenerative morphologic modifications in Zucker Diabetic Fatty (ZDF) rats, a genetic model of type 2 diabetes, by histologic and immunohistochemical evaluation. Methods: Male lean (?/+; n = 10) and ZDF (fa/fa; n = 20) rats were used. At 24 weeks of age, body weights and blood glucose levels were determined. Eyes were removed and processed for paraffin wax embedding. Sections through the optic disc were stained for hematoxylin and eosin or immunostained for TUNEL, advanced glycation end products (AGEs), glial fibrillary acidic protein (GFAP), glutamate/aspartate transporter (GLAST), isolectin B4, recoverin, retinal pigment epithelium-specific 65-kDa protein, rhodopsin, vimentin, and zonula occludens protein 1...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28895591/development-of-drug-loaded-polymer-microcapsules-for-treatment-of-epilepsy
#12
Yu Chen, Qi Gu, Zhilian Yue, Jeremy M Crook, Simon E Moulton, Mark J Cook, Gordon G Wallace
Despite significant progress in developing new drugs for seizure control, epilepsy still affects 1% of the global population and is drug-resistant in more than 30% of cases. To improve the therapeutic efficacy of epilepsy medication, a promising approach is to deliver anti-epilepsy drugs directly to affected brain areas using local drug delivery systems. The drug delivery systems must meet a number of criteria, including high drug loading efficiency, biodegradability, neuro-cytocompatibility and predictable drug release profiles...
September 26, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28883484/astrocytes-and-oligodendrocytes-in-grey-and-white-matter-regions-of-the-brain-metabolize-fatty-acids
#13
Kristina Hofmann, Rosalia Rodriguez-Rodriguez, Anne Gaebler, Núria Casals, Anja Scheller, Lars Kuerschner
The grey and white matter regions of the mammalian brain consist of both neurons and neuroglial cells. Among the neuroglia, the two macroglia oligodendrocytes and astrocytes are the most abundant cell types. While the major function of oligodendrocytes is the formation of the lipid-rich myelin structure, the heterogeneous group of astrocytes fulfils a multitude of important roles in cerebral development and homeostasis. Brain lipid homeostasis involves the synthesis of a specific cerebral lipidome by local lipid metabolism...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28861932/ion-mobility-enhanced-data-independent-acquisitions-enable-a-deep-proteomic-landscape-of-oligodendrocytes
#14
Juliana S Cassoli, Caroline Brandão-Teles, Aline G Santana, Gustavo H M F Souza, Daniel Martins-de-Souza
Oligodendrocytes are a type of neuroglia that provide trophic support and insulation to axons in the central nervous system. The genesis and maturation of oligodendrocytes are essential processes for myelination and the course of CNS development. Using ion mobility-enhanced, data-independent acquisitions and 2D-nanoUPLC fractionation operating at nanoscale flow rates, we established a comprehensive data set of proteins expressed by the human oligodendroglia cell line MO3.13. The final dataset incorporating all fractions comprised 223 531 identified peptides assigned to 10 390 protein hits, an improvement of 4...
September 1, 2017: Proteomics
https://www.readbyqxmd.com/read/28833751/a-proteomic-analysis-of-contextual-fear-conditioned-rats-reveals-dynamic-modifications-in-neuron-and-oligodendrocyte-protein-expression-in-the-dentate-gyrus
#15
Nicolas Houyoux, Ruddy Wattiez, Laurence Ris
Contextual memory is an intricate process involving synaptic plasticity and network rearrangement. Both are governed by many molecular processes including phosphorylation and modulation of protein expression. However, little is known about the molecules involved in it. Here, we exploited the advantages of a quantitative proteomic approach to identify a great number of molecules in the rat dentate gyrus after a contextual fear conditioning session. Our results allowed us to highlight protein expression patterns, not only related to neuroplasticity, but also to myelin structure, such as myelin basic protein and myelin proteolipid protein showing a decrease in expression...
August 22, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28814236/neuroglial-cell-cryopreservation-in-appropriate-inductive-conditions
#16
Rosa M Gomez, Maria Andrea Dominguez-Sanchez, Magdy M Sanchez, George E Barreto
An ability to store cells (if they cannot be used fresh) reduces cell wastage, thereby increasing the supply of transplantable material. Cell storage is also valuable in scientific research, allowing material to be archived and experiments to be repeated from the same tissue source and facilitating research collaboration by allowing stored samples to be distributed. Cryopreservation is currently considered the most promising and successful, long-term biological conservation method. Its use has led to optimizing survival, improving protocols and stem cell and neuroglia viability, thereby assuring its future use in neuroregeneration and restoration regarding cell therapy...
August 16, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28757154/the-central-serotonin2b-receptor-as-a-new-pharmacological-target-for-the-treatment-of-dopamine-related-neuropsychiatric-disorders-rationale-and-current-status-of-research
#17
REVIEW
Céline Devroye, Adeline Cathala, Pier Vincenzo Piazza, Umberto Spampinato
The serotonin2B receptor (5-HT2BR), which was first cloned and characterized in the rat stomach fundus, is the most recent addition to the 5-HT2R family. While its involvement in the regulation of gastrointestinal, vascular, pulmonary and cardiac physiology has been widely investigated, its functional role within the central nervous system (CNS) has received much less attention. Nevertheless, when considering the data available in the literature with regards to the regulatory control exerted by the central 5-HT2BR on dopamine (DA) and serotonin (5-HT) neuron activity, a very interesting picture emerges and highlights the key role of these receptors for future therapeutic strategies of DA-related neuropsychiatric disorders...
July 27, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28713614/condition-medium-of-cerebrospinal-fluid-and-retinoic-acid-induces-the-transdifferentiation-of-human-dental-pulp-stem-cells-into-neuroglia-and-neural-like-cells
#18
Sara Haratizadeh, Maryam Nazm Bojnordi, Shahram Darabi, Narges Karimi, Mehrdad Naghikhani, Hatef Ghasemi Hamidabadi, Morteza Seifi
Cerebrospinal fluid (CSF) contains several molecules which are essential for neurogenesis. Human dental pulp stem cells (hDPSCs) are putatively neural crest cell-derived that can differentiate into neurons and glial cells under appropriate neurotrophic factors. The aim of this study was to induce differentiation of hDPSCs into neuroglial phenotypes using retinoic acid (RA) and CSF. The hDPSCs from an impacted third molar were isolated by mechanical and digestion and cultured. The cells have treated by 10(-7) µM RA (RA group) for 8 days, 10% CSF (CSF group) for 8 days and RA with CSF for 8 days (RA/CSF group)...
June 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/28674992/neuroglia-functional-paralysis-and-reactivity-in-alzheimer-s-disease-and-other-neurodegenerative-pathologies
#19
Alexei Verkhratsky, Robert Zorec, J J Rodriguez, Vladimir Parpura
The most notable finding in neurodegenerative diseases is the progressive death of neurones cells. Yet, neuroglial changes can precede and facilitate neuronal loss. This is perhaps expected because astroglial cells maintain the brain homoeostasis, and are responsible for defence and regeneration, so that their malfunction manifested as degeneration or asthenia together with reactivity contribute to pathophysiology. Neuroglia may represent a novel target for therapeutic intervention, be that prevention, slowing progression of or possibly curing neurodegenerative diseases...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28570738/cellular-senescence-is-associated-with-human-retinal-microaneurysm-formation-during-aging
#20
Mariana López-Luppo, Joana Catita, David Ramos, Marc Navarro, Ana Carretero, Luísa Mendes-Jorge, Pura Muñoz-Cánoves, Alfonso Rodriguez-Baeza, Victor Nacher, Jesus Ruberte
Purpose: Microaneurysms are present in healthy old-age human retinas. However, to date, no age-related pathogenic mechanism has been implicated in their formation. Here, cellular senescence, a hallmark of aging and several age-related diseases, has been analyzed in the old-age human retina and in the retina of a progeric mouse. Methods: Retinas were obtained from 17 nondiabetic donors and from mice deficient in Bmi1. Cellular senescence was analyzed by immunohistochemistry, senescent-associated β-galactosidase activity assay, Sudan black B staining, conventional transmission electron microscopy, and immunoelectronmicroscopy...
June 1, 2017: Investigative Ophthalmology & Visual Science
keyword
keyword
61281
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"