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JOURNAL ARTICLE
Meixiang Xue, Shuangxi Cai, Ye Deng, Fang Luo, Jianhui Huang, Zhenyu Lin
T-2 toxin, a hazardous mycotoxin often present in cereals and products based on cereals, poses a substantial risk to humans and animals due to its high toxicity. The development of uncomplicated, quick and highly sensitive methods for detecting T-2 toxin is imperative. In this work, a portable sensing system was constructed using water column height as a readout device in combination with a controlled release system, which allows for an accurate quantitative analysis of T-2 toxin without the need for expensive instrumentation or skilled technicians...
May 4, 2024: Talanta
#2
JOURNAL ARTICLE
Judith M Sarneel, Mariet M Hefting, Taru Sandén, Johan van den Hoogen, Devin Routh, Bhupendra S Adhikari, Juha M Alatalo, Alla Aleksanyan, Inge H J Althuizen, Mohammed H S A Alsafran, Jeff W Atkins, Laurent Augusto, Mika Aurela, Aleksej V Azarov, Isabel C Barrio, Claus Beier, María D Bejarano, Sue E Benham, Björn Berg, Nadezhda V Bezler, Katrín Björnsdóttir, Martin A Bolinder, Michele Carbognani, Roberto Cazzolla Gatti, Stefano Chelli, Maxim V Chistotin, Casper T Christiansen, Pascal Courtois, Thomas W Crowther, Michele S Dechoum, Ika Djukic, Sarah Duddigan, Louise M Egerton-Warburton, Nicolas Fanin, Maria Fantappiè, Silvano Fares, Geraldo W Fernandes, Nina V Filippova, Andreas Fliessbach, David Fuentes, Roberto Godoy, Thomas Grünwald, Gema Guzmán, Joseph E Hawes, Yue He, Jean-Marc Hero, Laura L Hess, Katja Hogendoorn, Toke T Høye, Wilma W P Jans, Ingibjörg S Jónsdóttir, Sabina Keller, Sebastian Kepfer-Rojas, Natalya N Kuz'menko, Klaus S Larsen, Hjalmar Laudon, Jonas J Lembrechts, Junhui Li, Jean-Marc Limousin, Sergey M Lukin, Renato Marques, César Marín, Marshall D McDaniel, Qi Meek, Genrietta E Merzlaya, Anders Michelsen, Leonardo Montagnani, Peter Mueller, Rajasekaran Murugan, Isla H Myers-Smith, Stefanie Nolte, Raúl Ochoa-Hueso, Bernard N Okafor, Vladimir V Okorkov, Vladimir G Onipchenko, María C Orozco, Tina Parkhurst, Carlos A Peres, Matteo Petit Bon, Alessandro Petraglia, Martin Pingel, Corinna Rebmann, Brett R Scheffers, Inger Schmidt, Mary C Scholes, Efrat Sheffer, Lyudmila K Shevtsova, Stuart W Smith, Adriano Sofo, Pablo R Stevenson, Barbora Strouhalová, Anders Sundsdal, Rafael B Sühs, Gebretsadik Tamene, Haydn J D Thomas, Duygu Tolunay, Marcello Tomaselli, Simon Tresch, Dominique L Tucker, Michael D Ulyshen, Alejandro Valdecantos, Vigdis Vandvik, Elena I Vanguelova, Kris Verheyen, Xuhui Wang, Laura Yahdjian, Xaris S Yumashev, Joost A Keuskamp
The breakdown of plant material fuels soil functioning and biodiversity. Currently, process understanding of global decomposition patterns and the drivers of such patterns are hampered by the lack of coherent large-scale datasets. We buried 36,000 individual litterbags (tea bags) worldwide and found an overall negative correlation between initial mass-loss rates and stabilization factors of plant-derived carbon, using the Tea Bag Index (TBI). The stabilization factor quantifies the degree to which easy-to-degrade components accumulate during early-stage decomposition (e...
May 2024: Ecology Letters
#3
JOURNAL ARTICLE
Fangxuan Yi, Xiuxiu Chen, Fanyun Hou, Lisha Song, Shouqing Zhan, Xiaomin Wang, Rongfei Zhang, Qingqing Yang, Xiangyou Wang, Zhanli Liu
This study investigated the properties of chitosan/zein/tea polyphenols (C/Z/T) films and analyzed the release kinetics of tea polyphenols (TP) in various food simulants to enhance the sustainability and functionality of food packaging. The results revealed that TP addition enhanced the hydrophilicity, opacity and mechanical properties of film, and improved the compatibility between film matrix. 1.5 % TP film showed the lowest lightness (76.4) and the highest chroma (29.1), while 2 % TP film had the highest hue angle (1...
April 30, 2024: International Journal of Biological Macromolecules
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JOURNAL ARTICLE
Chen Chen, Yangfeng Peng, Yongming Wei, Mengyuan Liu, Yu Wang, Siqi Xiong, Huiyi Li, Quan He
Hydroxychloroquine (HCQ), 2-([4-([7-Chloro-4-quinolyl]amino)pentyl]ethylamino)ethanol, exhibited significant biological activity, while its side effects cannot be overlooked. The RP-HPLC enantio-separation was investigated for cost-effective and convenient optical purity analysis of HCQ. The thermodynamic resolution of Rac-HCQ, driven by enthalpy and entropy, was achieved on the C18 column using Carboxymethyl-β-cyclodextrin (CM-β-CD) as the chiral mobile phase agent (CMPA). The effects of CCM-β-CD , pH, and triethylamine (TEA) V% on the enantio-separation process were explored...
May 2024: Chirality
#5
JOURNAL ARTICLE
Structural investigation of Trypanosoma cruzi Akt-like kinase as drug target against Chagas disease.
Karina A Stadler, Lesly J Ortiz-Joya, Amit Singh Sahrawat, Christoph Buhlheller, Karl Gruber, Tea Pavkov-Keller, Treasa B O'Hagan, Alba Guarné, Sergio Pulido, Marcel Marín-Villa, Klaus Zangger, Nina Gubensäk
According to the World Health Organization, Chagas disease (CD) is the most prevalent poverty-promoting neglected tropical disease. Alarmingly, climate change is accelerating the geographical spreading of CD causative parasite, Trypanosoma cruzi, which additionally increases infection rates. Still, CD treatment remains challenging due to a lack of safe and efficient drugs. In this work, we analyze the viability of T. cruzi Akt-like kinase (TcAkt) as drug target against CD including primary structural and functional information about a parasitic Akt protein...
May 2, 2024: Scientific Reports
#6
JOURNAL ARTICLE
Lawrence Wengle, Chris Frampton, Peter C Poon
BACKGROUND: Total elbow arthroplasty (TEA) is an appropriate surgical treatment option for a variety of conditions ranging from inflammatory arthritis to trauma. Due to a high complication profile, implant companies have attempted to improve patient outcomes with evolving design mechanics and philosophy. However, the Nexel TEA prosthesis has been criticized for its unacceptably high revision rate by other research groups in the literature. The purpose of this study was to evaluate the survivorship and revision rates of the Nexel and Coonrad-Morrey total elbow arthroplasty implant systems in New Zealand...
April 26, 2024: Journal of Shoulder and Elbow Surgery
#7
REVIEW
Einar Stefan Björnsson
The incidence and prevalence of drug-induced liver injury appear to be increasing globally, for example, with the introduction of checkpoint inhibitors. Several reviews have been published in the last decade on the epidemiology of DILI, both among hospitalized patients and in the general population, as well as from retrospective and prospective studies on DILI. Most of these reviews have not focused on newly recognized agents that have recently changed the landscape of DILI. Apart from liver injury associated with antibiotics, oncological agents, particularly checkpoint inhibitors, are increasingly being recognized as causing liver injury...
April 18, 2024: Pharmaceuticals
#8
JOURNAL ARTICLE
Katherine G Holderby, J Ashot Kozak
Tetraethylammonium (TEA), a quaternary ammonium compound, is a well-known blocker of potassium channels belonging to various subfamilies, such as KV 1-3, KCa 1, 2 and prokaryotic KcsA. In many cases, TEA acts from the extracellular side by open pore blockade. TEA can also block transient receptor potential (TRP) cation channels, such as TRPM7, in a voltage-dependent manner. In human T lymphocytes, intracellular (cytosolic) TEA and its analog TMA (tetramethylammonium) inhibit TRPM7 channel currents in the outward but not inward direction...
2024: Frontiers in Pharmacology
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REVIEW
Michael T Stoddart, Georgios N Panagopoulos, Richard S Craig, Mark Falworth, David Butt, Will Rudge, Deborah Higgs, Addie Majed
BACKGROUND: Fractures of the distal humerus are a common fragility fracture in older adults. The purpose of this study was to systematically review the literature to produce pooled estimates of the outcomes of treatment using total elbow arthroplasty (TEA), open reduction and locking plate fixation (ORIF), hemiarthroplasty or with conservative management. METHODS: A systematic review of PUBMED and EMBASE databases was conducted for studies reporting outcomes of intra-articular fractures in older adults...
April 2024: Shoulder & Elbow
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JOURNAL ARTICLE
Chien-Hao Wang, Jai-Sing Yang, Chao-Jung Chen, San-Hua Su, Hsin-Yuan Yu, Yu-Ning Juan, Yu-Jen Chiu, Tsung-Jung Ho
OBJECTIVES: The protective effects and related mechanisms of Jing-Si herbal tea (JSHT) were investigated in cellular damage mediated by pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, on normal human lung fibroblast by multiomic platform analysis. MATERIALS AND METHODS: The in silico high-throughput target was analyzed using pharmacophore models by BIOVIA Discovery Studio 2022 with ingenuity pathway analysis software...
2024: Tzu chi medical journal
#11
JOURNAL ARTICLE
Zhong-Da Li, Fangfang Liu, Yanqiao Zeng, Yingnan Liu, Wenhe Luo, Feng Yuan, Su Li, Qi Li, Jiaxin Chen, Mayumi Fujita, Guofang Zhang, Yang Li
Epigallocatechin-3-gallate (EGCG) is an important tea polyphenol with anti-tumor potential. Our previous studies revealed that EGCG was a promising immune checkpoint inhibitor (ICI) as it could downregulate expression of programmed cell death 1 ligand 1 (PD-L1) in tumor cells, thereby resulting tumor killing effect. In particular, EGCG can effectively avoid the inflammatory storm caused by anti-tumor therapy, which is a healthy green capacity absent from many ICIs. However, the relationship between EGCG and programmed cell death 1 (PD-1) of T cells remains unclear...
April 20, 2024: International Immunopharmacology
#12
JOURNAL ARTICLE
Shengyang Zhou, Xiaojun Zhu, Shanshan Song, Maozhong Sun, Hua Kuang, Chuanlai Xu, Lingling Guo
Mycotoxins, as secondary metabolites produced by fungi, have been the focus of researchers in various countries and are considered to be one of the major risk factors in agricultural products. There is an urgent need for a rapid, simple and high-performance method to detect residues of harmful mycotoxins in agricultural foods. We have developed a gold nanoparticle-based multiplexed immunochromatographic strip biosensor that can simultaneously detect fifteen mycotoxins in cereal samples. With this optimized procedure, five representative mycotoxins, deoxynivalenol (DON), zearalenone (ZEN), T-2 toxin (T-2), tenuazonic acid (TEA) and alternariol (AOH) were detected in the range of 0...
August 2024: Food Microbiology
#13
JOURNAL ARTICLE
Wafaa A Shehata, Mostafa A Hammam, Amani R Elbakly, Noha Elkady
BACKGROUND: Psoriasis is an immune-mediated inflammatory skin disorder with a multifaceted pathogenesis. Immune dysregulation and immune cell dysfunction are among the mechanisms involved. TEA domain family member 4 (TEAD4) is suggested to play a role in psoriasis development. TEAD4 expression in keratinocytes may have a chemotactic effect and could disturb the function of FOXP3-positive T lymphocytes. This study aimed to evaluate the expressions of TEAD4 and FOXP3 in lesional, nonlesional psoriatic, and healthy skin and assess the clinical impact of their expression...
April 18, 2024: International Journal of Dermatology
#14
JOURNAL ARTICLE
Yen Vy Do, Quynh Nhu Thi Le, Nguyen Huu Nghia, Ngoc Duc Vu, Nhi Thi Yen Tran, N T Bay, Thi Tuu Tran, Long Giang Bach, Tan Phat Dao
Soursop ( Annona muricata L.) fruit tea is a health-beneficial product that promotes economic development and addresses the issue of excessive agricultural waste. Prolonging the shelf-life of soursop fruit tea has been of scientific interest currently. This study evaluated the effects of three types of packaging materials of soursop fruit tea (e.g., paper, paper-combined Polyetylen (PE), and aluminum-combined PE) and different storage temperatures (5, 15, 30, and 45°C) on various product characteristics, total polyphenol content (TPC), total flavonoid content (TFC), total ascorbic acid (TAA), and 2,2-diphenyl-1-picryl hydrazyl (DPPH)/2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical scavenging capacity during 4 weeks of storage...
April 2024: Food Science & Nutrition
#15
JOURNAL ARTICLE
Cian-Fen Jhuo, Chun-Jung Chen, Jason T C Tzen, Wen-Ying Chen
Mitochondrial dysfunction, a common cellular hallmark in both familial and sporadic forms of Parkinson's disease (PD), is assumed to play a significant role in pathologic development and progression of the disease. Teaghrelin, a unique bioactive compound in some oolong tea varieties, has been demonstrated to protect SH-SY5Y cells against 1-methyl-4-phenylpyridinium induced neurotoxicity by binding to the ghrelin receptor to activate the AMPK/SIRT1/PGC-1α pathway. In this study, an animal model was established using a neurotoxin, 1-methyl-4phenyl-1,2,3,6-tetrahydropyridine (MPTP), a byproduct of a prohibited drug, to evaluate the oral efficacy of teaghrelin on PD by monitoring motor dysfunction of mice in open field, pole, and bean walking tests...
April 15, 2024: Environmental Toxicology
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JOURNAL ARTICLE
Tobias Suske, Helena Sorger, Gabriele Manhart, Frank Ruge, Nicole Prutsch, Mark W Zimmerman, Thomas Eder, Diaaeldin I Abdallah, Barbara Maurer, Christina Wagner, Susann Schönefeldt, Katrin Spirk, Alexander Pichler, Tea Pemovska, Carmen Schweicker, Daniel Pölöske, Emina Hubanic, Dennis Jungherz, Tony Andreas Müller, Myint Myat Khine Aung, Anna Orlova, Ha Thi Thanh Pham, Kerstin Zimmel, Thomas Krausgruber, Christoph Bock, Mathias Müller, Maik Dahlhoff, Auke Boersma, Thomas Rülicke, Roman Fleck, Elvin Dominic de Araujo, Patrick Thomas Gunning, Tero Aittokallio, Satu Mustjoki, Takaomi Sanda, Sylvia Hartmann, Florian Grebien, Gregor Hoermann, Torsten Haferlach, Philipp Bernhard Staber, Heidi Anne Neubauer, Alfred Thomas Look, Marco Herling, Richard Moriggl
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive immature T cell cancer. Mutations in IL7R have been analyzed genetically, but downstream effector functions such as STAT5A and STAT5B hyperactivation are poorly understood. Here, we studied the most frequent and clinically challenging STAT5BN642H driver in T cell development and immature T cell cancer onset and compared it with STAT5A hyperactive variants in transgenic mice. Enhanced STAT5 activity caused disrupted T cell development and promoted an early T cell progenitor-ALL phenotype, with upregulation of genes involved in T cell receptor (TCR) signaling, even in absence of surface TCR...
April 15, 2024: Journal of Clinical Investigation
#17
JOURNAL ARTICLE
Tea Duvančić, Andreja Vukasović Barišić, Ana Čizmić, Mihovil Plečko, Ivan Bohaček, Domagoj Delimar
Developmental dysplasia of the hip (DDH) presents varying degrees of femoral head dislocation, with severe cases leading to the formation of a new articular surface on the external side of the iliac bone-the neoacetabulum. Despite conventional understanding suggesting otherwise, a tissue resembling hyaline cartilage is found in the neoacetabulum and acetabulum of Crowe III and IV patients, indicating a potential for hyaline cartilage development without mechanical pressure. To test this theory, acetabular and femoral head cartilage obtained from patients with DDH was stained with hematoxylin-eosin and toluidine blue...
April 8, 2024: Diagnostics
#18
JOURNAL ARTICLE
Yuan He, Shuang Zhu, Yu Zhang, Chin Ping Tan, Jianbin Zhang, Yuanfa Liu, Yong-Jiang Xu
BACKGROUND: Despite the abundance of research examining the effects of coffee, tea, and alcohol on inflammatory diseases, there is a notable absence of conclusive evidence regarding their direct causal influence on circulating inflammatory cytokines. Previous studies have primarily concentrated on established cytokines, neglecting the potential impact of beverage consumption on lesser-studied but equally important cytokines. METHODS: Information regarding the consumption of coffee, tea, and alcohol was collected from the UK Biobank, with sample sizes of 428,860, 447,485, and 462,346 individuals, respectively...
April 12, 2024: European Journal of Clinical Nutrition
#19
JOURNAL ARTICLE
Pasupathi M, Natarajan B, Kumar T
The overexposure of human skin to ultraviolet radiation (UVR) can trigger photodamage, UV burn, pigmentation, erythema, and enhance the chance of dermal carcinoma. UVR causes DNA damage, leading to dermal cancer. Daily sunscreen application protects the skin from the adverse effects of sun rays, particularly UVB (290-320 nm) and UVA (320-400 nm). The ozone layer filters UVC (200-290 nm) radiation upon entry into the Earth's atmosphere. UVB causes sunburn, photo damage, and induces mutagenic changes in nucleic acids...
April 12, 2024: Cutaneous and Ocular Toxicology
#20
JOURNAL ARTICLE
Reem Mahamoud, David T Bowman, Wendy E Ward, Vaughn Mangal
Preclinical rodent models are used to examine the relationship between tea consumption and bone health, where tea is available for rodents and typically replaced weekly. However, the extent to which the tea polyphenols change over time remains uncertain, despite its importance in preparing tea during preclinical rodent trials. Using an untargeted molecular approach, we applied a liquid chromatography quadrupole-time-of-flight mass spectrometry (LC-QTOFMS) system to assess the molecular profile of red rooibos teas throughout a 6-day aging period...
March 20, 2024: Food Chemistry
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