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https://www.readbyqxmd.com/read/27925140/tea-consumption-reduces-the-incidence-of-neurocognitive-disorders-findings-from-the-singapore-longitudinal-aging-study
#1
L Feng, M-S Chong, W-S Lim, Q Gao, M S Nyunt, T-S Lee, S L Collinson, T Tsoi, E-H Kua, T-P Ng
OBJECTIVES: To examine the relationships between tea consumption habits and incident neurocognitive disorders (NCD) and explore potential effect modification by gender and the apolipoprotein E (APOE) genotype. DESIGN: Population-based longitudinal study. SETTING: The Singapore Longitudinal Aging Study (SLAS). PARTICIPANTS: 957 community-living Chinese elderly who were cognitively intact at baseline. MEASUREMENTS: We collected tea consumption information at baseline from 2003 to 2005 and ascertained incident cases of neurocognitive disorders (NCD) from 2006 to 2010...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27908295/dopamine-2-receptor-extracellular-n-terminus-regulates-receptor-surface-availability-and-is-the-target-of-human-pathogenic-antibodies-from-children-with-movement-and-psychiatric-disorders
#2
Nese Sinmaz, Fiona Tea, Deepti Pilli, Alicia Zou, Mazen Amatoury, Tina Nguyen, Vera Merheb, Sudarshini Ramanathan, Sandra T Cooper, Russell C Dale, Fabienne Brilot
Anti-Dopamine-2 receptor (D2R) antibodies have been recently identified in a subgroup of children with autoimmune movement and psychiatric disorders, however the epitope(s) and mechanism of pathogenicity remain unknown. Here we report a major biological role for D2R extracellular N-terminus as a regulator of receptor surface availability, and as a major epitope targeted and impaired in brain autoimmunity. In transfected human cells, purified anti-D2R antibody from patients specifically and significantly reduced human D2R surface levels...
December 1, 2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/27905221/antioxidant-potentiality-of-three-herbal-teas-consumed-in-bandundu-rural-areas-of-congo
#3
Paulin Mutwale Kapepula, Patricia Mbombo Mungitshi, Thierry Franck, Ange Mouithys-Mickalad, Dieudonné Mumba Ngoyi, Pascal Dibungi T Kalenda, Nadege Kabamba Ngombe, Didier Serteyn, Monique Tits, Michel Frédérich, Jean-Jacques Tamfum Muyembe
The aim of this study was to evaluate and compare the cellular antioxidant activities of Lantana montevidensis, Lippia multiflora, and Ocimum gratissimum leaves often consumed as herbal teas in a rural area of Bandundu severely affected by konzo, which is related to oxidative damage. Consequently, dietary supplements with proven antioxidant potentialities could be of real interest to promote in this area. Phytochemical screening by TLC and HPLC-DAD of extracts revealed the presence of verbascoside as a major phenolic compound...
December 1, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27866076/antioxidant-properties-of-tea-blunt-ros-dependent-lipogenesis-beneficial-effect-on-hepatic-steatosis-in-a-high-fat-high-sucrose-diet-nafld-obese-rat-model
#4
Laura Braud, Sylvain Battault, Grégory Meyer, Alessandro Nascimento, Sandrine Gaillard, Georges de Sousa, Roger Rahmani, Catherine Riva, Martine Armand, Jean-Michel Maixent, Cyril Reboul
Oxidative stress could trigger lipid accumulation in liver and thus hepatic steatosis. Tea is able to prevent liver disorders, but a direct link between antioxidant capacities and prevention of steatosis has not been reported yet. We aimed to investigate such relationship in a rat model of high fat-high sucrose diet (HFS)-induced obesity and to explore more deeply the mechanisms in isolated hepatocytes. Wistar rats were divided into a control group (standard diet), an HFS group (high fat-sucrose diet) and an HFS+tea group (HFS diet with ad-libitum access to tea drink)...
October 29, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27855324/green-tea-polyphenol-epigallocatechin-3-gallate-differentially-induces-apoptosis-in-cll-b-and-t-cells-but-not-in-healthy-b-and-t-cells-in-a-dose-dependant-manner
#5
Scott Cornwall, Gavin Cull, David Joske, Reza Ghassemifar
B-cell chronic lymphocytic leukaemia (CLL) is characterized by an accumulation of CD5-positive monoclonal B-cells due in large part to a failure of apoptosis. The ability to study CLL B-cells in vitro has always been a challenge and hampered by the low viability of the CLL B-cells in cell culture systems. In this study, we present a multicellular cell culture system to maintain CLL B-cells viable in culture for 60h in the presence of a stromal cell feeder layer in combination with a whole white blood cell preparation...
November 2, 2016: Leukemia Research
https://www.readbyqxmd.com/read/27853259/comparative-transcriptome-analysis-of-chinary-assamica-and-cambod-tea-camellia-sinensis-types-during-development-and-seasonal-variation-using-rna-seq-technology
#6
Ajay Kumar, Vandna Chawla, Eshita Sharma, Pallavi Mahajan, Ravi Shankar, Sudesh Kumar Yadav
Tea quality and yield is influenced by various factors including developmental tissue, seasonal variation and cultivar type. Here, the molecular basis of these factors was investigated in three tea cultivars namely, Him Sphurti (H), TV23 (T), and UPASI-9 (U) using RNA-seq. Seasonal variation in these cultivars was studied during active (A), mid-dormant (MD), dormant (D) and mid-active (MA) stages in two developmental tissues viz. young and old leaf. Development appears to affect gene expression more than the seasonal variation and cultivar types...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27824754/raspberry-leaf-and-hypoglycemia-in-gestational-diabetes-mellitus
#7
Kai I Cheang, Thanh T Nguyen, Nicole W Karjane, Kelsey E S Salley
BACKGROUND: Raspberry leaf is commonly consumed by pregnant women. Hypoglycemic effects have been documented with other species within the plant family. Whether raspberry leaf affects glycemic control in gestational diabetes mellitus (GDM) is unknown. CASE: A 38-year-old nulliparous woman with GDM developed hypoglycemia requiring lowered insulin dose after consuming raspberry leaf tea at 32 weeks of gestation. The temporal relationship was confirmed by the patient's self-withdrawal and reintroduction of the herb...
December 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27805619/liver-related-safety-assessment-of-green-tea-extracts-in-humans-a-systematic-review-of-randomized-controlled-trials
#8
T Isomura, S Suzuki, H Origasa, A Hosono, M Suzuki, T Sawada, S Terao, Y Muto, T Koga
No abstract text is available yet for this article.
November 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27797683/short-term-effects-of-green-tea-on-blood-pressure-endothelial-function-and-metabolic-profile-in-obese-prehypertensive-women-a-crossover-randomized-clinical-trial
#9
Lívia de P Nogueira, José Firmino Nogueira Neto, Márcia R S T Klein, Antonio F Sanjuliani
BACKGROUND: Green tea consumption has been inversely associated with cardiovascular disease (CVD) in epidemiological studies. Although some interventional trials suggest that green tea has beneficial effects on CVD risk factors, such as hypertension and obesity, others have failed to show such benefits. AIMS: To evaluate the short-term effects of green tea on blood pressure, endothelial function, metabolic profile, and inflammatory activity in obese prehypertensive women...
October 31, 2016: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/27796716/association-of-breast-cancer-risk-in-brca1-and-brca2-mutation-carriers-with-genetic-variants-showing-differential-allelic-expression-identification-of-a-modifier-of-breast-cancer-risk-at-locus-11q22-3
#10
Yosr Hamdi, Penny Soucy, Karoline B Kuchenbaeker, Tomi Pastinen, Arnaud Droit, Audrey Lemaçon, Julian Adlard, Kristiina Aittomäki, Irene L Andrulis, Adalgeir Arason, Norbert Arnold, Banu K Arun, Jacopo Azzollini, Anita Bane, Laure Barjhoux, Daniel Barrowdale, Javier Benitez, Pascaline Berthet, Marinus J Blok, Kristie Bobolis, Valérie Bonadona, Bernardo Bonanni, Angela R Bradbury, Carole Brewer, Bruno Buecher, Saundra S Buys, Maria A Caligo, Jocelyne Chiquette, Wendy K Chung, Kathleen B M Claes, Mary B Daly, Francesca Damiola, Rosemarie Davidson, Miguel De la Hoya, Kim De Leeneer, Orland Diez, Yuan Chun Ding, Riccardo Dolcetti, Susan M Domchek, Cecilia M Dorfling, Diana Eccles, Ros Eeles, Zakaria Einbeigi, Bent Ejlertsen, Christoph Engel, D Gareth Evans, Lidia Feliubadalo, Lenka Foretova, Florentia Fostira, William D Foulkes, George Fountzilas, Eitan Friedman, Debra Frost, Pamela Ganschow, Patricia A Ganz, Judy Garber, Simon A Gayther, Anne-Marie Gerdes, Gord Glendon, Andrew K Godwin, David E Goldgar, Mark H Greene, Jacek Gronwald, Eric Hahnen, Ute Hamann, Thomas V O Hansen, Steven Hart, John L Hays, Frans B L Hogervorst, Peter J Hulick, Evgeny N Imyanitov, Claudine Isaacs, Louise Izatt, Anna Jakubowska, Paul James, Ramunas Janavicius, Uffe Birk Jensen, Esther M John, Vijai Joseph, Walter Just, Katarzyna Kaczmarek, Beth Y Karlan, Carolien M Kets, Judy Kirk, Mieke Kriege, Yael Laitman, Maïté Laurent, Conxi Lazaro, Goska Leslie, Jenny Lester, Fabienne Lesueur, Annelie Liljegren, Niklas Loman, Jennifer T Loud, Siranoush Manoukian, Milena Mariani, Sylvie Mazoyer, Lesley McGuffog, Hanne E J Meijers-Heijboer, Alfons Meindl, Austin Miller, Marco Montagna, Anna Marie Mulligan, Katherine L Nathanson, Susan L Neuhausen, Heli Nevanlinna, Robert L Nussbaum, Edith Olah, Olufunmilayo I Olopade, Kai-Ren Ong, Jan C Oosterwijk, Ana Osorio, Laura Papi, Sue Kyung Park, Inge Sokilde Pedersen, Bernard Peissel, Pedro Perez Segura, Paolo Peterlongo, Catherine M Phelan, Paolo Radice, Johanna Rantala, Christine Rappaport-Fuerhauser, Gad Rennert, Andrea Richardson, Mark Robson, Gustavo C Rodriguez, Matti A Rookus, Rita Katharina Schmutzler, Nicolas Sevenet, Payal D Shah, Christian F Singer, Thomas P Slavin, Katie Snape, Johanna Sokolowska, Ida Marie Heeholm Sønderstrup, Melissa Southey, Amanda B Spurdle, Zsofia Stadler, Dominique Stoppa-Lyonnet, Grzegorz Sukiennicki, Christian Sutter, Yen Tan, Muy-Kheng Tea, Manuel R Teixeira, Alex Teulé, Soo-Hwang Teo, Mary Beth Terry, Mads Thomassen, Laima Tihomirova, Marc Tischkowitz, Silvia Tognazzo, Amanda Ewart Toland, Nadine Tung, Ans M W van den Ouweland, Rob B van der Luijt, Klaartje van Engelen, Elizabeth J van Rensburg, Raymonda Varon-Mateeva, Barbara Wappenschmidt, Juul T Wijnen, Timothy Rebbeck, Georgia Chenevix-Trench, Kenneth Offit, Fergus J Couch, Silje Nord, Douglas F Easton, Antonis C Antoniou, Jacques Simard
PURPOSE: Cis-acting regulatory SNPs resulting in differential allelic expression (DAE) may, in part, explain the underlying phenotypic variation associated with many complex diseases. To investigate whether common variants associated with DAE were involved in breast cancer susceptibility among BRCA1 and BRCA2 mutation carriers, a list of 175 genes was developed based of their involvement in cancer-related pathways. METHODS: Using data from a genome-wide map of SNPs associated with allelic expression, we assessed the association of ~320 SNPs located in the vicinity of these genes with breast and ovarian cancer risks in 15,252 BRCA1 and 8211 BRCA2 mutation carriers ascertained from 54 studies participating in the Consortium of Investigators of Modifiers of BRCA1/2...
October 28, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27794395/arginine-kinase-in-toxocara-canis-exon-intron-organization-functional-analysis-of-site-directed-mutants-and-evaluation-of-putative-enzyme-inhibitors
#11
Susiji Wickramasinghe, Lalani Yatawara, Mitsuru Nagataki, Takeshi Agatsuma
OBJECTIVES: To determine exon/intron organization of the Toxocara canis (T. canis) AK (TCAK) and to test green and black tea and several other chemicals against the activity of recombinant TCAK in the guanidino-specific region by site-directed mutants. METHODS: Amplification of genomic DNA fragments containing introns was carried out by PCRs. The open-reading frame (1200 bp) of TCAK (wild type) was cloned into the BamH1/SalI site of pMAL-c2X. The maltose-binding protein-TCAK fusion protein was expressed in Escherichia coli TB1 cells...
October 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27784921/protein-rich-beverage-developed-using-non-gm-soybean-r08-4004-and-evaluated-for-sensory-acceptance-and-shelf-life
#12
Quyen Nguyen, Navam Hettiarachchy, Srinivas Rayaprolu, Han-Seok Seo, Ronny Horax, Pengyin Chen, Thallapuranam K Suresh Kumar
Protein beverages have been in demand due to an increasing consumers' interest in healthy eating habit. However, there is an increased concern on the use of genetic modified (GM) ingredient in the food product. This study aimed to develop protein hydrolysate beverages using a non-GM soybean (R08-4004/high protein line) grown in Arkansas. Protein isolate was prepared from the soybean using alkaline method (pH 9.5). Due to its poor solubility in acidic condition, alcalase 2.4 L (food grade protease) hydrolyzed soy protein was used to develop a beverage containing 20 g protein per serving (500 mL)...
August 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27784919/bioassay-guided-screening-optimization-and-characterization-of-antioxidant-compounds-from-high-altitude-wild-edible-plants-of-ladakh
#13
Anupama Sharma Avasthi, Manisha Bhatnagar, Nandan Sarkar, Surinder Kitchlu, Sabari Ghosal
Seven edible plants including three unexplored species of high altitude (Ladakh) region were screened for antioxidant activity by bioassay guided fractionation method. The objective of the study was to dereplicate the complex phytochemical matrix of a plant in reference to antioxidant activity in vitro. The screening result showed that ethylacetate fraction of Nepeta longibracteata possesses maximum antioxidant activity, comparable to that of green tea. It also exhibited significant protecting effect against oxidative stress induced by t-BHP in human RBCs...
August 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27784787/epigallocatechin-gallate-remodels-overexpressed-functional-amyloids-in-pseudomonas-aeruginosa-and-increases-biofilm-susceptibility-to-antibiotic-treatment
#14
Marcel Stenvang, Morten S Dueholm, Brian S Vad, Thomas W Seviour, Guanghong Zeng, Susana Geifman-Shochat, Mads T Søndergaard, Gunna Christiansen, Rikke Louise Meyer, Staffan Kjelleberg, Per Halkjær Nielsen, Daniel E Otzen
Epigallocatechin-3-gallate (EGCG) is the major polyphenol in green tea. It has anti-microbial properties and disrupts the ordered structure of amyloid fibrils involved in human disease. The anti-microbial effect of EGCG against the opportunistic pathogen Pseudomonas aeruginosa has been shown to involve disruption of quorum sensing (QS). Functional amyloid fibrils in P. aeruginosa (Fap) are able to bind and retain quorum sensing molecules, suggesting that EGCG interferes with QS through structural remodeling of amyloid fibrils...
October 26, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27774417/green-tea-catechin-inhibits-the-activity-and-neutrophil-release-of%C3%A2-matrix-metalloproteinase-9
#15
Wan K Kim-Park, Eman S Allam, Jadesada Palasuk, Michael Kowolik, Kichuel K Park, L Jack Windsor
Green tea (Camellia sinensis; lǜ chá) extracts have been shown to possess anti-oxidant and anti-inflammatory effects in various cell types. Green tea extract (GTX) has been shown to significantly inhibit the activity of collagenase-3 (matrix metalloproteinase-13 (MMP-13)) in vitro. MMPs, such as MMP-9, are known to be involved in many inflammatory diseases including periodontal disease. GTX and a major catechin, epigallocatechin-gallate (EGCG), were examined for their ability to inhibit purified MMP-9 activity and its release from stimulated neutrophils...
October 2016: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27760989/mechanisms-underlying-the-endogenous-dopaminergic-inhibition-of-spinal-locomotor-circuit-function-in-xenopus-tadpoles
#16
Laurence D Picton, Keith T Sillar
Dopamine plays important roles in the development and modulation of motor control circuits. Here we show that dopamine exerts potent effects on the central pattern generator circuit controlling locomotory swimming in post-embryonic Xenopus tadpoles. Dopamine (0.5-100 μM) reduced fictive swim bout occurrence and caused both spontaneous and evoked episodes to become shorter, slower and weaker. The D2-like receptor agonist quinpirole mimicked this repertoire of inhibitory effects on swimming, whilst the D4 receptor antagonist, L745,870, had the opposite effects...
October 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27748172/herb-drug-interactions-an-insight-into-cardiovascular-diseases-based-on-case-reports
#17
Maria Campos, C Batista, N R Jesus, C M Silva, T P Silva
Cardiovascular patients frequently use herbal medicinal products, in order to contribute to the improvement of their chronic condition without medical intervention. However, they are likely to suffer from adverse effects from natural products and herb-drug interactions. This work aimed to alert cardiovascular patients and healthcare providers of the potential of occurrence of herb-drug interactions with cardiovascular therapy. Information obtained from the campaign "Aprender Saúde Entre as Plantas e os Medicamentos", carried out by the Observatory of Herb-Drug Interactions (www...
October 7, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27733975/might-e-cadherin-promoter-polymorphisms-of-rs16260-and-rs5030625-associate-with-the-risk-of-nephrolithiasis
#18
Cigdem Donmez, Ece Konac, Batuhan T Aydogan, Cenk Y Bilen
PURPOSE: To study whether -160 C > A (rs16260) and -347 G > GA (rs5030625) single nucleotide polymorphisms of the regulatory region (rSNPs) of CDH1 gene modulate the risk of nephrolithiasis. METHODS: Genomic DNA of 101 patients with calcium oxalate nephrolithiasis and 114 healthy controls were screened for both polymorphisms, using polymerase chain reaction-restriction fragments length polymorphism method (PCR-RLFP). Haplotype frequencies were also analyzed...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27717663/fuzhuan-tea-reverses-arterial-stiffening-after-modest-weight-gain-in-mice
#19
Dustin M Lee, Micah L Battson, Dillon K Jarrell, Kimberly Cox-York, Michelle T Foster, Tiffany L Weir, Christopher L Gentile
OBJECTIVES: The aim of this study was to examine the effects of a Western diet (WD) and supplementation with Fuzhuan tea on large artery stiffness, as determined by aortic pulse wave velocity (aPWV). METHODS: Mice were subjected to a standard diet (SD; n = 12) or WD (n = 10) for 7 mo, and were then separated to receive nonsupplemented drinking water (SD-W and WD-W) or water supplemented with Fuzhuan tea (SD-T and WD-T) (200 mg/kg daily); mice were then maintained on their respective diets for an additional 2 mo...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27711889/probing-the-excited-state-relaxation-dynamics-of-pyrimidine-nucleosides-in-chloroform-solution
#20
Katharina Röttger, Hugo J B Marroux, Hendrik Böhnke, David T J Morris, Angus T Voice, Friedrich Temps, Gareth M Roberts, Andrew J Orr-Ewing
Ultrafast transient electronic and vibrational absorption spectroscopy (TEAS and TVAS) of 2'-deoxy-cytidine (dC) and 2'-deoxy-thymidine (dT) dissolved in chloroform examines their excited-state dynamics and the recovery of ground electronic state molecules following absorption of ultraviolet light. The chloroform serves as a weakly interacting solvent, allowing comparisons to be drawn with prior experimental studies of the photodynamics of these nucleosides in the gas phase and in polar solvents such as water...
September 16, 2016: Faraday Discussions
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