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Clomipramine

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https://www.readbyqxmd.com/read/29752209/blockade-of-voltage-dependent-k-current-in-rabbit-coronary-arterial-smooth-muscle-cells-by-the-tricyclic-antidepressant-clomipramine
#1
Hongliang Li, Sung Eun Shin, Jin Ryeol An, Mi Seon Seo, Kwon-Soo Ha, Eun-Taek Han, Seok-Ho Hong, Amy L Firth, Dae-Sung Lee, Mi-Jin Yim, Jeong Min Lee, Grace Choi, Il-Whan Choi, Won Sun Park
We investigated the effect of the tricyclic antidepressant clomipramine on voltage-dependent K+ (Kv) channels in native rabbit coronary arterial smooth muscle cells. Our results showed that clomipramine inhibited vascular Kv channels in a concentration-dependent manner, with an IC50 value of 8.61 ± 4.86 μM and a Hill coefficient (n) of 0.58 ± 0.07. The application of 10 μM clomipramine did not affect the activation curves of the Kv channels; however, the inactivation curves of the Kv channels were shifted toward a more negative potential...
April 27, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29745454/effects-of-short-term-clomipramine-on-anxiety-like-behavior-cellular-metabolism-and-oxidative-stress-in-primary-fibroblast-cells-of-male-and-female-rats
#2
Ana G Jimenez, Joshua D Winward, Dana M Smith, Christina M Ragan
Anxiety is the most prevalent mental disorder among adults in the United States and females tend to have significantly higher rates of anxiety compared with men. Common treatments for anxiety include usage of selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants, however, sex differences in the efficacy of these drugs exist. In this study, we were interested in determining if acutely manipulating serotonin mechanisms at the whole-animal level affects cellular metabolism and oxidative stress in primary fibroblast cells from clomipramine-treated Sprague-Dawley rats...
May 2018: Physiological Reports
https://www.readbyqxmd.com/read/29741917/a-systematic-review-of-pharmacologic-treatments-for-school-refusal-behavior
#3
Amalia Londono Tobon, Margot O Reed, Jerome H Taylor, Michael H Bloch
OBJECTIVE: School refusal is an important pediatric problem with significant negative short- and long-term outcomes. Specific psychosocial treatments appear effective in reducing school refusal, but many children do not respond to these treatments. Although systematic reviews have examined the efficacy of psychological interventions for school refusal, no systematic reviews on pharmacological interventions exist. METHODS: We conducted a comprehensive literature search of MEDLINE, PsycINFO, Scopus, and Embase for randomized controlled trials (RCTs) or quasi-experimental pharmacologic trials in children and adolescents with school refusal reported in English or Spanish until July 1, 2017...
May 9, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29741894/structures-of-ebolavirus-glycoprotein-complexes-with-tricyclic-antidepressant-and-antipsychotic-drugs
#4
Yuguang Zhao, Jingshan Ren, Elizabeth Evelyn Fry, Julia Xiao, Alain R Townsend, David I Stuart
A large number of Food and Drug Administration (FDA) approved drugs have been found to inhibit cell entry of Ebola virus (EBOV). However, since these drugs have various primary pharmacological targets their mechanisms of action against EBOV remain largely unknown. We have previously shown that six FDA approved drugs inhibit EBOV infection by interacting with and destabilizing the viral glycoprotein (GP). Here we show that the antidepressants imipramine and clomipramine, and antipsychotic drug thioridazine also directly interact with EBOV GP, and determine the mode of interaction by crystallographic analysis of the complexes...
May 9, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29726395/in-vitro-and-in-vivo-drug-combination-for-the-treatment-of-trypanosoma-cruzi-infection-a-multivariate-approach
#5
Mariana Strauss, Jean Henrique S Rodrigues, María Silvina Lo Presti, Paola Carolina Bazán, Alejandra Lidia Báez, Patricia Paglini-Oliva, Celso Vataru Nakamura, Juan Manuel Bustamante, Héctor Walter Rivarola
Combination therapies based on the available drugs have been proposed as promising therapeutic alternatives for many diseases. Clomipramine (CLO) has been found to modify the evolution of the experimental infection. The objective of this study was to evaluate the combined effect of benznidazole (BZ) and clomipramine (CLO) against different life-stages of Trypanosoma cruzi in vitro and their efficacy in a murine model. Life-stages of T. cruzi, BZ-partially-resistant (Y) strain, were incubated with BZ and CLO and isobolograms and combination index (CI) were obtained...
April 18, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29718600/relative-efficacy-and-acceptability-of-antidepressant-drugs-in-adults-with-major-depressive-disorder-commentary-on-a-network-meta-analysis
#6
Chittaranjan Andrade
A large number of antidepressant drugs are available across the world. All have been compared against placebo, and many have been compared with some but not all other antidepressants. There is therefore little information about a hierarchy of the efficacy and acceptability of these drugs. About 9 years ago, a network meta-analysis attempted to rank the efficacy and acceptability of 12 newer antidepressant drugs in adults with major depressive disorder. Very recently, this network meta-analysis was updated to include 21 antidepressant drugs, most of which were introduced during the 1980s and afterward...
March 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29682419/inducible-nitric-oxide-synthase-nos2-knockout-mice-as-a-model-of-trichotillomania
#7
Plinio C Casarotto, Caroline Biojone, Karina Montezuma, Fernando Q Cunha, Samia R L Joca, Eero Castren, Francisco S Guimaraes
Background: Trichotillomania (TTM) is an impulse control disorder characterized by repetitive hair pulling/trimming. Barbering behavior (BB) observed in laboratory animals is proposed as a model of TTM. The neurobiological basis of TTM is unclear, but involves striatal hyperactivity and hypoactivation of the prefrontal cortex. Methods: In this study, we evaluated the BB in knockout mice for the inducible isoform of nitric oxide synthase (NOS2KO) and the consequences of silencing this enzyme in PC12 cell differentiation...
2018: PeerJ
https://www.readbyqxmd.com/read/29626770/estimating-environmental-fate-of-tricyclic-antidepressants-in-wastewater-treatment-plant
#8
Jong-Won Choi, Yufeng Zhao, John Kwame Bediako, Chul-Woong Cho, Yeoung-Sang Yun
TCAs are known to be toxicants and endocrine disrupting agents. Generally, after being used, TCAs are passed through wastewater treatment plants (WWTPs) to be treated. However, still trace amounts (ng/L to μg/L) of TCAs have been founded even in the treated water. Therefore, the aim of this study is to elucidate the environmental behaviors of TCAs in the sewage water from WWTPs (Jeonju, Korea). For the experiments, seven TCAs (amitriptyline, imipramine, clomipramine, desipramine, protriptyline, nortriptyline, and doxepin) were selected...
April 4, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29621962/maternal-hair-and-neonatal-meconium-to-assess-gestational-consumption-and-prenatal-exposure-to-drugs-of-abuse-and-psychoactive-drugs
#9
Francesco Paolo Busardo, Laura Almeida, Laura Cortes, Sally Sabraa, Marta Muniesaa, Oscar Garcia-Algara, Maria Dolores Gomez-Roiga
BACKGROUND: In the last two decades, the consumption of drugs of abuse among women of childbearing age has experienced a significant increase and results from analyses of surveys concerning maternal intake of psychoactive prescription drugs during pregnancy indicate that the rates of intake are increasing each year. Analyses of biological matrices such as maternal hair and neonatal meconium have recently been used for assessment of gestational consumption and consequent prenatal exposure to drugs of abuse in high-risk groups of women METHODS: Maternal hair and neonatal meconium were analyzed by validated chromatographic mass spectrometric methodologies to disclose gestational use of drugs of abuse and psychoactive prescription drugs and consequent prenatal exposure in a cohort of 513 mother-newborn dyads at the Sant Joan de Déu Barcelona Hospital, Spain, during 2012- 2013...
April 5, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29595359/feline-hyperaesthesia-syndrome-with-self-trauma-to-the-tail-retrospective-study-of-seven-cases-and-proposal-for-integrated-multidisciplinary-diagnostic-approach
#10
Pablo Amengual Batle, Clare Rusbridge, Tim Nuttall, Sarah Heath, Katia Marioni-Henry
Case series summary This was a retrospective study on the clinical features and response to treatment in seven cats with feline hyperaesthesia syndrome (FHS) and tail mutilation. FHS is a poorly understood disorder characterised by skin rippling over the dorsal lumbar area, episodes of jumping and running, excessive vocalisation, and tail chasing and self-trauma. The majority of the cats were young, with a median age of 1 year at the onset of clinical signs, male (n = 6) and with access to the outdoors (n = 5)...
March 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29582445/development-of-new-extraction-method-based-on-liquid-liquid-liquid-extraction-followed-by-dispersive-liquid-liquid-microextraction-for-extraction-of-three-tricyclic-antidepressants-in-plasma-samples
#11
Mir Ali Farajzadeh, Maryam Abbaspour
In the present study, a new extraction method based on a three-phase system liquid-liquid-liquid extraction followed by dispersive liquid-liquid microextraction has been developed and validated for the extraction and preconcentration of three commonly prescribed tricyclic antidepressant drugs including amitriptyline, imipramine, and clomipramine in human plasma prior to their analysis by gas chromatography-flame ionization detection. Three phases are an aqueous phase (plasma), acetonitrile, and n-hexane. The extraction mechanism is based on the different affinities of components of the biological sample (lipids, fatty acids, pharmaceuticals, inorganic ions, etc...
March 27, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29502389/second-generation-antipsychotic-and-diabetes-mellitus-in-children-and-adolescents
#12
Carlo Ripoli, Anna Paola Pinna, Faustina Podda, Roberta Zanni, Maria Giada Tronci, Anna Maria Nurchi
Second generation antipsychotics (SGA) are used in children for the treatment of various psychiatric diseases, including pervasive developmental disorders. These drugs can cause metabolic effects as hyperglycemia and diabetes. A 16-year-old young-boy, diagnosed with autism, developed diabetes mellitus type 1 whilst he was on treatment with olanzapine (started 4 months before), clomipramine, valproic acid and lithium. The hypothesis of druginduced diabetes imposed olanzapine interruption and clozapine initiation...
December 13, 2017: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
https://www.readbyqxmd.com/read/29477251/comparative-efficacy-and-acceptability-of-21-antidepressant-drugs-for-the-acute-treatment-of-adults-with-major-depressive-disorder-a-systematic-review-and-network-meta-analysis
#13
Andrea Cipriani, Toshi A Furukawa, Georgia Salanti, Anna Chaimani, Lauren Z Atkinson, Yusuke Ogawa, Stefan Leucht, Henricus G Ruhe, Erick H Turner, Julian P T Higgins, Matthias Egger, Nozomi Takeshima, Yu Hayasaka, Hissei Imai, Kiyomi Shinohara, Aran Tajika, John P A Ioannidis, John R Geddes
BACKGROUND: Major depressive disorder is one of the most common, burdensome, and costly psychiatric disorders worldwide in adults. Pharmacological and non-pharmacological treatments are available; however, because of inadequate resources, antidepressants are used more frequently than psychological interventions. Prescription of these agents should be informed by the best available evidence. Therefore, we aimed to update and expand our previous work to compare and rank antidepressants for the acute treatment of adults with unipolar major depressive disorder...
April 7, 2018: Lancet
https://www.readbyqxmd.com/read/29427324/uptake-and-metabolism-of-the-antidepressants-sertraline-clomipramine-and-trazodone-in-a-garden-cress-lepidium-sativum-model
#14
Bernd Reichl, Markus Himmelsbach, Lisa Emhofer, Christian W Klampfl, Wolfgang Buchberger
Environmental contamination with pharmaceuticals has received growing attention in recent years. Several studies describe the presence of traces of drugs in water bodies and soils and their impacts on nontarget organisms including plants. Due to these facts investigations of the uptake and metabolism of pharmaceuticals in organisms is an emerging research area. The present study demonstrates the analysis of three selected antidepressants (sertraline, clomipramine, and trazodone) as well as metabolites and transformation products in a cress model (Lepidium sativum)...
February 10, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29407872/early-postnatal-treatment-with-clomipramine-induces-female-sexual-behavior-and-estrous-cycle-impairment
#15
Tania Molina-Jiménez, Ofelia Limón-Morales, Herlinda Bonilla-Jaime
Administration of clomipramine (CMI), a tricyclic antidepressant, in early stages of development in rats, is considered an animal model for the study of depression. This pharmacological manipulation has induced behavioral and physiological alterations, i.e., less pleasure-seeking behaviors, despair, hyperactivity, cognitive dysfunction, alterations in neurotransmitter systems and in HPA axis. These abnormalities in adult male rats are similar to the symptoms observed in major depressive disorders. One of the main pleasure-seeking behaviors affected in male rats treated with CMI is sexual behavior...
March 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29367071/joint-effects-of-nine-antidepressants-on-raphidocelis-subcapitata-and-skeletonema-marinoi-a-matter-of-amine-functional-groups
#16
Laetitia Minguez, Ronan Bureau, Marie-Pierre Halm-Lemeille
Antidepressants are among the most prescribed pharmaceuticals throughout the world. Their presence has already been detected in several aquatic ecosystems worldwide and their effects on non-target organisms justify the growing concern of both the public and regulatory authorities. These emerging pollutants do not occur as isolated compounds but rather as multi-component mixtures, which may lead to increased adverse effects compared to individual compounds. Freshwater and marine algae seem particularly sensitive to pharmaceuticals, including antidepressants...
March 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29332813/fast-and-easy-extraction-of-antidepressants-from-whole-blood-using-ionic-liquids-as-extraction-solvent
#17
Marieke De Boeck, Lisa Dubrulle, Wim Dehaen, Jan Tytgat, Eva Cuypers
This study aims to prove that ionic liquids (ILs) can be used as extraction solvents in a liquid-liquid microextraction, coupled to LC-MS/MS, for the quantification of a large group of antidepressants in whole blood samples. The sample preparation procedure consisted of adding 1.0mL aqueous buffer pH 3.0 and 60µL of IL (1-butyl-3-methylimidazolium hexafluorophosphate) to 1.0mL whole blood. Subsequently, a 5-min rotary mixing step was performed followed by centrifugation. The lower IL phase was collected, diluted 1:10 in methanol and 10µL was injected into the LC-MS/MS...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29278206/a-systematic-review-of-evidence-based-treatment-strategies-for-obsessive-compulsive-disorder-resistant-to-first-line-pharmacotherapy
#18
Umberto Albert, Donatella Marazziti, Gabriele Di Salvo, Francesca Solia, Gianluca Rosso, Giuseppe Maina
BACKGROUND: Serotonin reuptake inhibitors (SRIs) and cognitive-behavioral psychotherapy (CBT) are first-line treatments for obsessive-compulsive disorder (OCD). However, a significant proportion of patients do not respond satisfactorily to first-choice treatments. Several options have been investigated for the management of resistant patients. OBJECTIVE: The aim of the present paper is to systematically review the available literature concerning the strategies for the treatment of resistant adult patients with OCD...
December 22, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29259169/systematic-screening-of-generic-drugs-for-progressive-multiple-sclerosis-identifies-clomipramine-as-a-promising-therapeutic
#19
Simon Faissner, Manoj Mishra, Deepak K Kaushik, Jianxiong Wang, Yan Fan, Claudia Silva, Gail Rauw, Luanne Metz, Marcus Koch, V Wee Yong
The treatment of progressive multiple sclerosis (MS) is unsatisfactory. One reason is that the drivers of disease, which include iron-mediated neurotoxicity, lymphocyte activity, and oxidative stress, are not simultaneously targeted. Here we present a systematic screen to identify generic, orally available medications that target features of progressive MS. Of 249 medications that cross the blood-brain barrier, 35 prevent iron-mediated neurotoxicity in culture. Of these, several antipsychotics and antidepressants strongly reduce T-cell proliferation and oxidative stress...
December 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29203842/tolerability-and-adequate-therapeutic-dosage-of-oral-clomipramine-for-the-treatment-of-premature-ejaculation-a-randomized-double-blind-placebo-controlled-fixed-dose-parallel-grouped-clinical-study
#20
Sae Woong Kim, Jin Bong Choi, Su Jin Kim, Kyung Soo Kim, Churl Min Kim, Dong Hyeon Lee, Whan Seok Choi
To evaluate the adequate therapeutic dosage of clomipramine 15 mg/day and clomipramine 30 mg/day in male patients with premature ejaculation (PE), this study enrolled men aged 20-65 years who met diagnostic criteria for PE including Intravaginal Ejaculation Latency Time (IELT) less than 2 min for at least 75% of their sexual intercourses. Subjects received placebo, clomipramine 15 mg, or clomipramine 30 mg prn (2~6 h before intercourse) for 4 weeks. Efficacy was assessed using fold change, percentile change, and mean change of IELT, as well as Drug Coitus Interval Time (DCIT)...
December 4, 2017: International Journal of Impotence Research
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