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https://www.readbyqxmd.com/read/28181921/feed-induced-dystonias-in-children-with-severe-central-nervous-system-disorders
#1
Santosh Mordekar, Manjula Velayudhan, David I Campbell
Dystonias can arise from any painful stimuli in neurologically disabled children. Classically, feed induced dystonias from mediastinal pain due to severe gastroesophageal reflux disease are described as Sandifer's spasm. We report a case series of 12 severely neurologically impaired children with enteral feed induced dystonias. Intestinal dysmotility was demonstrated in several. Improvements are seen with jejunal feeds or gut rest with Total Parenteral Nutrition. Use of parenteral nutrition in children with severe neurodisability requires thorough discussion with patient groups and commissioners to give clinicians guidelines to standardise care...
February 8, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28145588/the-promise-of-epigenetics-for-neurodisability
#2
EDITORIAL
Bernard Dan
No abstract text is available yet for this article.
March 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28135121/robotic-assisted-minimally-invasive-total-esophagogastric-dissociation-for-children-with-severe-neurodisability
#3
Girolamo Mattioli, Francesco Molinaro, Irene Paraboschi, Lorenzo Leonelli, Cinzia Mazzola, Serena Arrigo, Margherita Mancardi, Alessio Pini Prato, Rossella Angotti, Mario Messina, Adrian Bianchi
BACKGROUND: Around 70% of children with neurodisability (ND) present pharyngeal neuromuscular incoordination and severe gastroesophageal reflux disease (GORD). METHODS: This is a pilot study with the Robotic-assisted minimally invasive total esophagogastric dissociation (TOGD). RESULTS: We included 4 patients, 2 males and 2 females, with ND and severe GORD refractory to medical treatment. CONCLUSIONS: Pharmacological management of GORD is often unsuccessful and antireflux surgery is common, but it has a high failure rate with symptom recurrence, requiring re-do surgery...
January 30, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28128036/book-review-developmental-assessment-theory-practice-and-application-to-neurodisability-sonksen-pm-developmental-assessment-theory-practice-and-application-to-neurodisability-london-mac-keith-press-2016-370-pp-65-00-isbn-978-1-909962-56-9
#4
https://www.readbyqxmd.com/read/28096103/failure-and-success-in-severe-gastrointestinal-disease-complicating-neurodisability-who-is-at-the-end-of-the-line
#5
EDITORIAL
John W L Puntis, Michelle Hills
No abstract text is available yet for this article.
January 17, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28073351/exploring-neurodevelopmental-outcome-measures-used-in-children-with-cerebral-malaria-the-perspectives-of-caregivers-and-health-workers-in-malawi
#6
Emmie W Mbale, Terrie Taylor, Bernard Brabin, Macpherson Mallewa, Melissa Gladstone
BACKGROUND: Progress has been made in tackling malaria however there are still over 207 million cases worldwide, the majority in children. As survival rates improve, numbers of children with long-term neurodisabling sequelae are likely to increase. Most outcome studies in cerebral malaria (CM) have focused only on body function and structure and less on outcomes within the broader framework of the International Classification of Functioning and Disability (ICF). The aim of this study was to utilise qualitative methods to identify relevant clinical outcomes in CM to support formulation of a core outcome set relevant to CM and other acquired brain injuries for use in future clinical trials...
January 10, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28024307/ethics-in-child-health-principles-and-cases-in-neurodisability
#7
Oswald Hasselmann
No abstract text is available yet for this article.
February 2017: Neuropediatrics
https://www.readbyqxmd.com/read/28011793/protecting-the-premature-brain-current-evidence-based-strategies-for-minimising-perinatal-brain-injury-in-preterm-infants
#8
Charlotte L Lea, Adam Smith-Collins, Karen Luyt
Improving neurodevelopmental outcome for preterm infants is an important challenge for neonatal medicine. The disruption of normal brain growth and neurological development is a significant consequence of preterm birth and can result in physical and cognitive impairments. While advances in neonatal medicine have led to progressively better survival rates for preterm infants, there has only been a modest improvement in the proportion of surviving infants without neurological impairment, and no change in the proportion with severe disability...
December 23, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27836825/intestinal-failure-in-children-and-young-people-with-neurodisabling-conditions
#9
REVIEW
Amar M Wahid, Colin V Powell, Ieuan H Davies, Jennifer A Evans, Huw R Jenkins
Gastrointestinal dysmotility is common in children and young people with neurodisabling conditions. In this article we seek to highlight the increasing difficulties faced by paediatricians in managing intestinal failure in this patient group. It is becoming clear that, as the median age for survival increases, intestinal failure is a significant problem, and can in some cases become life-limiting. The ethical issues around starting children with life-limiting conditions on parenteral nutrition (PN) are extremely complicated, not least because we are ignorant of the mechanism of intestinal failure in these children, and indeed, which of these children might be able to return to enteral feeding after a period of PN...
November 11, 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27833905/perspectives-on-disease-and-disability-in-child-health-the-case-of-childhood-neurodisability
#10
REVIEW
Anton Rodney Miller, Peter Rosenbaum
Chronic health conditions are often associated with what is termed disability. Traditional thinking has focused on diagnosis and treatment of chronic diseases and disorders, with less attention to people's functional abilities and their contextual determinants. Understanding all of these factors is integral to addressing the predicaments and needs of persons with chronic conditions. However, these complementary yet distinct "worldviews" reflected in what we call disease and disability perspectives often remain, at best, only vaguely articulated...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27766678/improving-participation-outcomes-and-interventions-in-neurodisability-co-designing-future-research
#11
J McAnuff, R Brooks, C Duff, M Quinn, J Marshall, N Kolehmainen
There is an urgent, agreed need to improve participation outcomes and interventions for children and young people with neurodisability. We worked together with service users and providers to design research into participation outcomes and interventions in neurodisability. We built on existing evidence about participation outcomes and interventions and the WHO International Classification of Functioning, Disability and Health. We: (1) specified seven participation outcome categories for measurement; (2) prioritized these for improvement: self-care, friends and social, and physical activity ranked the highest; (3) identified 11 potential intervention categories for targeting the top priority, self-care, through eight hypothesized change mechanisms and agreed for the interventions to be delivered as a 'Menu of Interventions' for personalized self-care support; and (4) designed a before-and-after mixed methods feasibility study to evaluate the Menu with children and young people (0-12 years) and their parents and therapists...
October 21, 2016: Child: Care, Health and Development
https://www.readbyqxmd.com/read/27706248/democratizing-neurorehabilitation-how-accessible-are-low-cost-mobile-gaming-technologies-for-self-rehabilitation-of-arm-disability-in-stroke
#12
Paul Rinne, Michael Mace, Tagore Nakornchai, Karl Zimmerman, Susannah Fayer, Pankaj Sharma, Jean-Luc Liardon, Etienne Burdet, Paul Bentley
Motor-training software on tablets or smartphones (Apps) offer a low-cost, widely-available solution to supplement arm physiotherapy after stroke. We assessed the proportions of hemiplegic stroke patients who, with their plegic hand, could meaningfully engage with mobile-gaming devices using a range of standard control-methods, as well as by using a novel wireless grip-controller, adapted for neurodisability. We screened all newly-diagnosed hemiplegic stroke patients presenting to a stroke centre over 6 months...
2016: PloS One
https://www.readbyqxmd.com/read/27703996/host-biomarkers-are-associated-with-response-to-therapy-and-long-term-mortality-in-pediatric-severe-malaria
#13
Andrea L Conroy, Michael Hawkes, Chloe R McDonald, Hani Kim, Sarah J Higgins, Kevin R Barker, Sophie Namasopo, Robert O Opoka, Chandy C John, W Conrad Liles, Kevin C Kain
Background.  Host responses to infection are critical determinants of disease severity and clinical outcome. The development of tools to risk stratify children with malaria is needed to identify children most likely to benefit from targeted interventions. Methods.  This study investigated the kinetics of candidate biomarkers of mortality associated with endothelial activation and dysfunction (angiopoietin-2 [Ang-2], soluble FMS-like tyrosine kinase-1 [sFlt-1], and soluble intercellular adhesion molecule-1 [sICAM-1]) and inflammation (10 kDa interferon γ-induced protein [CXCL10/IP-10] and soluble triggering receptor expressed on myeloid cells-1 [sTREM-1]) in the context of a randomized, double-blind, placebo-controlled, parallel-arm trial evaluating inhaled nitric oxide versus placebo as adjunctive therapy to parenteral artesunate for severe malaria...
September 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27696390/assessment-of-the-family-environment-in-pediatric-neurodisability-a-state-of-the-art-review
#14
REVIEW
Marjolijn Ketelaar, Aline Bogossian, Michael Saini, Anne Visser-Meily, Lucyna Lach
The importance of the family environment for the development of children with neurodisabilities is undisputed. The objective of this study is to describe how family environment has been measured in research on families of children with neurodisabilities, in order to support researchers and clinicians to select appropriate methods for use. A three-step approach was used and 13 measures of family environment were identified within 77 studies. Five measures were used most commonly across a majority of studies (n=50)...
March 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27607909/pediatric-antipsychotic-use-and-outcomes-monitoring
#15
Paramala J Santosh, Laura Bell, Federico Fiori, Jatinder Singh
Antipsychotic (ATP) prescription rates have increased in children and adolescents despite concern regarding the safety and effectiveness of ATP usage in community populations. Rising safety concerns and uncertainty regarding ATP effectiveness in children stress the need for improvement in routine clinical outcome monitoring and research. Due to the growing number of children exposed to atypical ATPs, studies assessing the risk/benefit ratio of administering ATPs in this age group-especially in off-label conditions-become of high importance...
September 8, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27562095/a-comparative-historical-and-demographic-study-of-the-neuromodulation-management-techniques-of-deep-brain-stimulation-for-dystonia-and-cochlear-implantation-for-sensorineural-deafness-in-children
#16
V E Hudson, A Elniel, I Ughratdar, B Zebian, R Selway, J P Lin
: Cochlear implants for sensorineural deafness in children is one of the most successful neuromodulation techniques known to relieve early chronic neurodisability, improving activity and participation. In 2012 there were 324,000 recipients of cochlear implants globally. AIM: To compare cochlear implant (CI) neuromodulation with deep brain stimulation (DBS) for dystonia in childhood and explore relations between age and duration of symptoms at implantation and outcome...
January 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27539482/the-impact-of-a-sepsis-quality-improvement-project-on-neurodisability-rates-in-very-low-birthweight-infants
#17
Jonathan W Davis, David Odd, Sally Jary, Karen Luyt
OBJECTIVE: Very low birthweight (VLBW; <1500 g) infants with late-onset sepsis (LOS) have an increased risk of neurodisability. Care bundles to reduce bloodstream infections in neonatal intensive care unit (NICU) are effective in reducing LOS. Our aim was to determine if a sepsis reduction bundle introduced through a quality improvement project would impact neurodevelopmental outcomes in VLBW infants. DESIGN: Cohort study. SETTING: Level 3 regional NICU in the South West of England...
August 18, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27422381/weakly-acidic-ph-reduces-inflammatory-cytokine-expression-in-airway-epithelial-cells
#18
A P Hackett, R E Trinick, K Rose, B F Flanagan, P S McNamara
BACKGROUND: Aspiration lung disease (ALD) is a common cause of respiratory morbidity in children and adults with severe neurodisability (sND). Recent studies suggest that chronic microaspiration of gastric contents is associated with mild rather than low, airway acidification. We investigated inflammatory responses to infection by airway epithelial cells (AECs) exposed to weakly acidic media. METHODS: Using pH measurements from children with sND at high risk of ALD as a guide, we incubated AECs in weakly acidic (pH5...
2016: Respiratory Research
https://www.readbyqxmd.com/read/27299366/the-placenta-and-neurodisability
#19
Eugen Boltshauser
No abstract text is available yet for this article.
August 2016: Neuropediatrics
https://www.readbyqxmd.com/read/27186577/acute-kidney-injury-is-common-in-pediatric-severe-malaria-and-is-associated-with-increased-mortality
#20
Andrea L Conroy, Michael Hawkes, Robyn E Elphinstone, Catherine Morgan, Laura Hermann, Kevin R Barker, Sophie Namasopo, Robert O Opoka, Chandy C John, W Conrad Liles, Kevin C Kain
Background.  Acute kidney injury (AKI) is a well recognized complication of severe malaria in adults, but the incidence and clinical importance of AKI in pediatric severe malaria (SM) is not well documented. Methods.  One hundred eighty children aged 1 to 10 years with SM were enrolled between 2011 and 2013 in Uganda. Kidney function was monitored daily for 4 days using serum creatinine (Cr). Acute kidney injury was defined using the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. Blood urea nitrogen (BUN) and Cr were assessed using i-STAT, and cystatin C (CysC) was measured by enzyme-linked immunosorbent assay...
March 2016: Open Forum Infectious Diseases
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