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william Bauman

Ashraf S Gorgey, Zachary A Graham, William A Bauman, Christopher Cardozo, David R Gater
STUDY DESIGN: Longitudinal design. OBJECTIVES: The study determined the effects of two forms of exercise training on the abundance of two proteins, (glucose transporter-4 [GLUT-4], adenosine monophosphate kinase [AMPK]) involved in glucose utilization and the transcriptional coactivator that regulates the genes involved in energy metabolism and mitochondrial biogenesis (peroxisome proliferator-activated receptor (PPAR) coactivator 1 alpha [PGC-1α]), in muscles in men with chronic motor-complete spinal cord injury (SCI)...
October 13, 2016: Journal of Spinal Cord Medicine
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Linda Bauman, Karina W Davidson, John W Epling, Francisco A R García, Jessica Herzstein, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael P Pignone
IMPORTANCE: Tuberculosis remains an important preventable disease in the United States. An effective strategy for reducing the transmission, morbidity, and mortality of active disease is the identification and treatment of latent tuberculosis infection (LTBI) to prevent progression to active disease. OBJECTIVE: To issue a current US Preventive Services Task Force (USPSTF) recommendation on screening for LTBI. EVIDENCE REVIEW: The USPSTF reviewed the evidence on screening for LTBI in asymptomatic adults seen in primary care, including evidence dating from the inception of searched databases...
September 6, 2016: JAMA: the Journal of the American Medical Association
William G Albergotti, Kara S Davis, Shira Abberbock, Julie E Bauman, James Ohr, David A Clump, Dwight E Heron, Umamaheswar Duvvuri, Seungwon Kim, Jonas T Johnson, Robert L Ferris
BACKGROUND: Pretreatment body mass index (BMI) >25kg/m(2) is a positive prognostic factor in patients with head and neck cancer. Previous studies have not been adequately stratified by human papilloma virus (HPV) status or subsite. Our objective is to determine prognostic significance of pretreatment BMI on overall survival in HPV+ oropharyngeal squamous cell carcinoma (OPSCC). METHODS: This is a retrospective review of patients with HPV+ OPSCC treated between 8/1/2006 and 8/31/2014...
September 2016: Oral Oncology
Simion I Chiosea, Lester D R Thompson, Ilan Weinreb, Julie E Bauman, Alyssa M Mahaffey, Caitlyn Miller, Robert L Ferris, William E Gooding
BACKGROUND: The authors hypothesized that histogenetic classification of salivary duct carcinoma (SDC) could account for de novo tumors and those with morphologic or molecular evidence (pleomorphic adenoma gene 1 [PLAG1], high-mobility group AT hook 2 [HMGA2] rearrangement, amplification) of pleomorphic adenoma (PA). METHODS: SDCs (n = 66) were reviewed for morphologic evidence of PA. PLAG1 and HMGA2 alterations were detected by fluorescence in situ hybridization (FISH)...
July 5, 2016: Cancer
Weiping Qin, Xiaodong Li, Yuanzhen Peng, Lauren M Harlow, Yinshi Ren, Yingjie Wu, Jiliang Li, Yiwen Qin, Jie Sun, Shijia Zheng, Tom Brown, Jian Q Feng, Hua Zhu Ke, William A Bauman, Christopher P Cardozo
No abstract text is available yet for this article.
July 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Marylou Guihan, Min-Woong Sohn, William A Bauman, Ann M Spungen, Gail M Powell-Cope, Susan S Thomason, Joseph F Collins, Barbara M Bates-Jensen
OBJECTIVE: To identify characteristics associated with pressure ulcer (PrU) healing for individuals with spinal cord injury (SCI) DESIGN: Secondary analysis of a large clinical trial data for healing PrUs in individuals with SCI; Prospective Delphi process was conducted with SCI and/or PrU experts. SETTING: US Department of Veterans Affairs Spinal Cord Injury Centers PARTICIPANTS: 629 screening and 162 treatment participants; 185 SCI clinicians/national PrU/wound care experts participated in the Delphi process...
June 30, 2016: Archives of Physical Medicine and Rehabilitation
Jill M Wecht, Christopher M Cirnigliaro, Frank Azarelo, Alexander T Lombard, William A Bauman, Steven C Kirshblum
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Michael F La Fountaine, Christopher M Cirnigliaro, Steven C Kirshblum, Ann M Spungen, William A Bauman
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Jedediah H May, Geoffrey R Rieser, Chad G Williams, Ronald J Markert, Ryan D Bauman, Matthew W Lawless
BACKGROUND: Administration of tranexamic acid topically and intravenously has demonstrated effectiveness in decreasing blood loss and transfusion rates. METHODS: We randomized 131 patients undergoing primary total knee arthroplasty to receive either intracapsular (69) or intravenous tranexamic acid (62). Postoperative blood loss was calculated using the formula derived by Nadler et al. The number of units transfused was recorded, as well as length of hospital stay...
April 30, 2016: Journal of Arthroplasty
Jessica L Geiger, Julie E Bauman, Michael K Gibson, William E Gooding, Prakash Varadarajan, Athanasios Kotsakis, Daniel Martin, Jorge Silvio Gutkind, Matthew L Hedberg, Jennifer R Grandis, Athanassios Argiris
BACKGROUND: Patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) demonstrate aberrant activation of the phosphotidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway. We examined the efficacy of everolimus, an mTOR inhibitor, in patients with recurrent or metastatic HNSCC. METHODS: This single-arm phase II study enrolled biomarker-unselected patients with recurrent or metastatic HNSCC who failed at least 1 prior therapy...
May 27, 2016: Head & Neck
Philip B Adamson, William T Abraham, Lynne Warner Stevenson, Akshay S Desai, JoAnn Lindenfeld, Robert C Bourge, Jordan Bauman
BACKGROUND: This study examines the impact of pulmonary artery pressure-guided heart failure (HF) care on 30-day readmissions in Medicare-eligible patients. METHODS AND RESULTS: The CardioMicroelectromechanical system (CardioMEMS) Heart Sensor Allows Monitoring of Pressures to Improve Outcomes in New York Heart Association Class III Heart Failure Patients (CHAMPION) Trial included 550 patients implanted with a permanent MEMS-based pressure sensor in the pulmonary artery...
June 2016: Circulation. Heart Failure
Tyler M Bauman, Emily A Ricke, Sally A Drew, Wei Huang, William A Ricke
Immunohistochemistry is a commonly used clinical and research lab detection technique for investigating protein expression and localization within tissues. Many semi-quantitative systems have been developed for scoring expression using immunohistochemistry, but inherent subjectivity limits reproducibility and accuracy of results. Furthermore, the investigation of spatially overlapping biomarkers such as nuclear transcription factors is difficult with current immunohistochemistry techniques. We have developed and optimized a system for simultaneous investigation of multiple proteins using high throughput methods of multiplexed immunohistochemistry and multispectral imaging...
2016: Journal of Visualized Experiments: JoVE
Khurram M Siddiqui, Michele Billia, Ali Al-Zahrani, Andrew Williams, Christopher Goodman, Andrew Arifin, Philippe Violette, Glenn Bauman, Joseph L Chin
PURPOSE: Management of localized radio-recurrent prostate cancer is not standardized, partly due to the absence of long-term data on oncologic control and the toxicity of various treatment modalities. We analyzed the long-term oncologic outcomes and morbidity of salvage cryoablation for radio-recurrent prostate cancer. MATERIALS AND METHODS: Patients undergoing salvage cryoablation for biopsy proven, localized radio-recurrent prostate cancer from 1995 to 2004 were prospectively accrued...
October 2016: Journal of Urology
John P Handrakis, Dwindally Rosado-Rivera, Kamaldeep Singh, Kirsten Swonger, Frank Azarelo, Alex T Lombard, Ann M Spungen, Steven C Kirshblum, William A Bauman
OBJECTIVE: Cervical spinal cord injury (tetraplegia) is known to interrupt sympathetic vasculature control, thereby preventing shunting of blood from the periphery to central organs when exposed to cold temperatures. As a result, persons with tetraplegia are at risk to develop hypothermia. However, information regarding the discomfort experienced during the cooler months (late fall, winter, early spring) is overwhelmingly anecdotal. It is not known, with any certainty, how those with tetraplegia perceive cold and if discomfort in colder environments restricts them from performing activities that they routinely would perform...
March 8, 2016: Journal of Spinal Cord Medicine
Tyler M Bauman, Chad M Vezina, Emily A Ricke, Richard B Halberg, Wei Huang, Richard E Peterson, William A Ricke
The purpose of this study was to objectively investigate β-catenin and LEF1 abundance, subcellular localization, and colocalization across benign and staged prostate cancer (PCa) specimens. A tissue microarray containing tumor-adjacent histologically benign prostate tissue (BPT; n = 48 patients), high-grade prostatic intraepithelial neoplasia (HGPIN; n = 25), localized PCa (n = 42), aggressive PCa (n = 31), and metastases (n = 22) was stained using multiplexed immunohistochemistry with antibodies toward E-cadherin, β-catenin, and LEF1...
May 2016: Human Pathology
Matthew L Hedberg, Gerald Goh, Simion I Chiosea, Julie E Bauman, Maria L Freilino, Yan Zeng, Lin Wang, Brenda B Diergaarde, William E Gooding, Vivian W Y Lui, Roy S Herbst, Richard P Lifton, Jennifer R Grandis
No abstract text is available yet for this article.
April 1, 2016: Journal of Clinical Investigation
Maria R Costanzo, Lynne W Stevenson, Philip B Adamson, Akshay S Desai, J Thomas Heywood, Robert C Bourge, Jordan Bauman, William T Abraham
OBJECTIVES: This study sought to analyze medical therapy data from the CHAMPION (CardioMEMS Heart Sensor Allows Monitoring of Pressure to Improve Outcomes in Class III Heart Failure) trial to determine which interventions were linked to decreases in heart failure (HF) hospitalizations during ambulatory pulmonary artery (PA) pressure-guided management. BACKGROUND: Elevated cardiac filling pressures, which increase the risk of hospitalizations and mortality, can be detected using an ambulatory PA pressure monitoring system before onset of symptomatic congestion allowing earlier intervention to prevent HF hospitalizations...
May 2016: JACC. Heart Failure
Jill M Wecht, Joseph P Weir, Miroslav Radulovic, William A Bauman
We previously showed that increases in mean arterial pressure (MAP) following administration of midodrine hydrochloride (MH) and nitro-L-arginine methyl ester (L-NAME) resulted in increased mean cerebral blood flow velocity (MFV) during head-up tilt in hypotensive individuals with spinal cord injury (SCI) and question if this same association was evident during cognitive activation. Herein, we report MAP and MFV during two serial subtraction tasks (SSt) given before (predrug) and after (postdrug) administration of MH; (10 mg), L-NAME (1 mg/kg) or no drug (ND) in 15 subjects with SCI compared to nine able-bodied (AB) controls...
February 2016: Physiological Reports
William A Ricke, Calvin W Lee, Tyler R Clapper, Andrew J Schneider, Robert W Moore, Kimberly P Keil, Lisa L Abler, Jalissa L Wynder, Arnaldo López Alvarado, Isaac Beaubrun, Jenny Vo, Tyler M Bauman, Emily A Ricke, Richard E Peterson, Chad M Vezina
Benign prostatic hyperplasia, prostate cancer, and changes in the ratio of circulating testosterone and estradiol often occur concurrently in aging men and can lead to lower urinary tract (LUT) dysfunction. To explore the possibility of a fetal basis for the development of LUT dysfunction in adulthood, Tg(CMV-cre);Nkx3-1(+/-);Pten(fl/+) mice, which are genetically predisposed to prostate neoplasia, were exposedin uteroand during lactation to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 1 μg/kg po) or corn oil vehicle (5 ml/kg) after a single maternal dose on 13 days post coitus, and subsequently were aged without further manipulation, or at 8 weeks of age were exposed to exogenous 17 β-estradiol (2...
April 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
Jill M Wecht, Joseph P Weir, William A Bauman
Background Due to interruption of cardiovascular autonomic control unstable blood pressure (BP) is common in individuals with spinal cord injury (SCI) above the sixth thoracic vertebral level. The impact of unstable BP on cerebral blood flow (CBF) is not well appreciated, but symptoms associated with altered cerebral perfusion are reported, which can negatively impact daily life activities. Methods We measured seated BP and CBF in participants with SCI and able-bodied (AB) controls on three laboratory visits to determine the inter-day reliability (intraclass correlation coefficient: ICC)...
February 10, 2016: Journal of Spinal Cord Medicine
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