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JOURNAL ARTICLE
Cassandra M Turcotte, Audrey M Choi, Jeffrey K Spear, Eva M Hernandez-Janer, Hannah G Taboada, Michala K Stock, Catalina I Villamil, Samuel E Bauman, Melween I Martinez, Lauren J N Brent, Noah Snyder-Mackler, Michael J Montague, Michael L Platt, Scott A Williams, James P Higham, Susan C Antón
OBJECTIVES: Interpretations of the primate and human fossil record often rely on the estimation of somatic dimensions from bony measures. Both somatic and skeletal variation have been used to assess how primates respond to environmental change. However, it is unclear how well skeletal variation matches and predicts soft tissue. Here, we empirically test the relationship between tissues by comparing somatic and skeletal measures using paired measures of pre- and post-mortem rhesus macaques from Cayo Santiago, Puerto Rico...
March 6, 2024: American journal of biological anthropology
#2
JOURNAL ARTICLE
Cassandra M Turcotte, Audrey M Choi, Jeffrey K Spear, Eva M Hernandez-Janer, Edwin Dickinson, Hannah G Taboada, Michala K Stock, Catalina I Villamil, Samuel E Bauman, Melween I Martinez, Lauren J N Brent, Noah Snyder-Mackler, Michael J Montague, Michael L Platt, Scott A Williams, Susan C Antón, James P Higham
OBJECTIVES: Estimation of body mass from skeletal metrics can reveal important insights into the paleobiology of archeological or fossil remains. The standard approach constructs predictive equations from postcrania, but studies have questioned the reliability of traditional measures. Here, we examine several skeletal features to assess their accuracy in predicting body mass. MATERIALS AND METHODS: Antemortem mass measurements were compared with common skeletal dimensions from the same animals postmortem, using 115 rhesus macaques (male: n = 43; female: n = 72)...
March 6, 2024: American journal of biological anthropology
#3
JOURNAL ARTICLE
Natalie M Diaz-Cabrera, Bradly M Bauman, Mildred A Iro, Gina Dabbah-Krancher, Vered Molho-Pessach, Abraham Zlotogorski, Oded Shamriz, Yael Dinur-Schejter, Tatyana Dubnikov Sharon, Polina Stepensky, Yuval Tal, Eli M Eisenstein, Leonora Pietzsch, Catharina Schuetz, Damien Abreu, Carrie C Coughlin, Megan A Cooper, Joshua D Milner, Anthony Williams, Gil Armoni-Weiss, Andrew L Snow, Jennifer W Leiding
The caspase activation and recruitment domain 11 (CARD11) gene encodes a scaffold protein required for lymphocyte antigen receptor signaling. Dominant-negative, loss-of-function (LOF) pathogenic variants in CARD11 result in CARD11-associated atopy with dominant interference of NF-κB signaling (CADINS) disease. Patients with CADINS suffer with severe atopic manifestations including atopic dermatitis, food allergy, and chronic spontaneous urticaria in addition to recurrent infections and autoimmunity. We assessed the response of dupilumab in five patients and omalizumab in one patient with CADINS for the treatment of severe atopic symptoms...
January 17, 2024: Journal of Clinical Immunology
#4
JOURNAL ARTICLE
Yuanzhen Peng, Solomon Langermann, Priyanka Kothari, Linda Liu, Wei Zhao, Yizhong Hu, Zihao Chen, Mariana Moraes de Lima Perini, Jiliang Li, Jay Cao, X Edward Guo, Lieping Chen, William A Bauman, Weiping Qin
Rapid and extensive sublesional bone loss after spinal cord injury (SCI) is a difficult medical problem that has been refractory to available interventions except the antiresorptive agent denosumab (DMAB). While DMAB has shown some efficacy in inhibiting bone loss, its concurrent inhibition of bone formation limits its use. Sialic acid-binding immunoglobulin-like lectin (Siglec)-15 is expressed on the cell surface of mature osteoclasts. Anti-Siglec-15 antibody (Ab) has been shown to inhibit osteoclast maturation and bone resorption while maintaining osteoblast activity, which is distinct from current antiresorptive agents that inhibit the activity of both osteoclasts and osteoblasts...
December 2023: JBMR Plus
#5
JOURNAL ARTICLE
Julie K Rehman, Gwen R Rempel, Elina Williams, Leanne Meakins, Mary E Bauman, M Patricia Massicotte, Roberta Davis, Judy Dahl, Andrew S Mackie
BACKGROUND: Fontan surgery is performed at 2-4 years of age and is the third planned surgical intervention for children with a univentricular heart. Major challenges for children and parents after Fontan include (a) psychological distress, (b) prolonged pleural drainage, and (c) the need for postoperative anticoagulation. The aim of this study was to evaluate a pre-Fontan video-based intervention for parents to address these challenges. METHODS: This study is a single-centre mixed-methods cluster randomized controlled trial...
August 2023: CJC Pediatr Congenit Heart Dis
#6
JOURNAL ARTICLE
Evert A Eriksson, Amanda Waite, SarahAnn S Whitbeck, John A Bach, Zachary M Bauman, Lindsey Cavlovic, Kate Dale, William B DeVoe, Andrew R Doben, John G Edwards, Joseph D Forrester, Adam J Kaye, John Green, Jeremy Hsu, Andrea Hufford, Christopher Janowak, Susan Kartiko, Ernest E Moore, Bhavik Patel, Fredrick Pieracci, Babak Sarani, Sebastian D Schubl, Gregory Semon, Bradley W Thomas, Jamie Tung, Esther M M Van Lieshout, Thomas W White, Mathieu M E Wijffels, Martin E Wullschleger
BACKGROUND: Over the last two decades, the acute management of rib fractures has changed significantly. In 2021, the Chest Wall injury Society (CWIS) began recognizing centers who epitomize their mission as CWIS Collaborative Centers (CWIS-CC). The primary aim of this study was to determine the resources, surgical expertise, access to care, and institutional support that are present among centers. METHODS: A survey was performed including all CWIS-CC evaluating the resources available at their hospital for the treatment of patients with chest wall injury...
October 26, 2023: Journal of Trauma and Acute Care Surgery
#7
JOURNAL ARTICLE
Nicole Nathan, Alix Hall, Adam Shoesmith, Adrian E Bauman, Belinda Peden, Bernadette Duggan, Carly Gardner, Cassandra Lane, Christophe Lecathelinais, Christopher Oldmeadow, Craig Duncan, Daniel Groombridge, Edward Riley-Gibson, Emma Pollock, James Boyer, John Wiggers, Karen Gillham, Martina Pattinson, Megan Mattingly, Nicole McCarthy, Patti-Jean Naylor, Penny Reeves, Philippa Budgen, Rachel Sutherland, Rebecca Jackson, Thomas Croft, William Pascoe, Luke Wolfenden
BACKGROUND: Governments internationally have invested hugely in the implementation and scale-up of school-based physical activity interventions, but have little evidence of how to best sustain these interventions once active implementation support ceases. This study will assess the effectiveness of a multi-strategy sustainability intervention on classroom teachers' sustainment of energisers (short 3-5 min physical activity breaks during class-time) scheduled across the school day from baseline to 12 and 24-month follow-up...
October 7, 2023: BMC Public Health
#8
JOURNAL ARTICLE
Mark M Aloysius, Mark A Korsten, Miroslav Radulovic, Kamaldeep Singh, Brian L Lyons, Tradd Cummings, Joshua Hobson, Sandeep Kahal, Ann M Spungen, William A Bauman
BACKGROUND: Effect of biofeedback on improving anorectal manometric parameters in incomplete spinal cord injury is unknown. A short-term biofeedback program investigated any effect on anorectal manometric parameters without correlation to bowel symptoms. METHODS: This prospective uncontrolled interventional study comprised three study subject groups, Group 1: sensory/motor-complete American Spinal Injury Association Impairment Scale (AIS) A SCI (n = 13); Group 2 (biofeedback group): sensory incomplete AIS B SCI (n = 17) (n = 3), and motor-incomplete AIS C SCI (n = 8), and AIS D SCI (n = 6); and Group 3: able-bodied (AB) controls (n = 12)...
September 25, 2023: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
#9
JOURNAL ARTICLE
Shawn K Gilhooley, William A Bauman, Michael F La Fountaine, Gregory T Cross, Steven C Kirshblum, Ann M Spungen, Christopher M Cirnigliaro
CONTEXT/OBJECTIVE: To identify cardiometabolic (CM) measurements that cluster to confer increased cardiovascular disease (CVD) risk using principal component analysis (PCA) in a cohort of chronic spinal cord injury (SCI) and healthy non-SCI individuals. APPROACH: A cross-sectional study was performed in ninety-eight non-ambulatory men with chronic SCI and fifty-one healthy non-SCI individuals (ambulatory comparison group). Fasting blood samples were obtained for the following CM biomarkers: lipid, lipoprotein particle, fasting glucose and insulin concentrations, leptin, adiponectin, and markers of inflammation...
September 11, 2023: Journal of Spinal Cord Medicine
#10
REVIEW
Megan M J Bauman, Luciano C P C Leonel, Maria Peris-Celda, Alice S Rhoton-Vlasak
The careers of the Mayo brothers, Harvey Cushing, and Sir William Osler greatly shaped medical and surgical practice in the late 19th and early 20th century and created a legacy that would influence decades of physicians to follow. Additionally, these men were instrumental in the founding of neurosurgery as a distinct surgical specialty. Alongside these great men, Dr. Albert Rhoton Jr. revolutionized neurosurgical practice through his study of neuroanatomy and development of microsurgical technique in the second half of the 20th century...
September 6, 2023: World Neurosurgery
#11
JOURNAL ARTICLE
Evert Austin Eriksson, Mathieu Mathilde Eugene Wijffels, Adam Kaye, Joseph Derek Forrester, Manuel Moutinho, Sarah Majerick, Zachary Mitchel Bauman, Christopher Francis Janowak, Bhavik Patel, Martin Wullschleger, Leanna Clevenger, Esther M M Van Lieshout, Jamie Tung, Michelle Woodfall, Thomas Russell Hill, Thomas William White, Andrew Ross Doben
PURPOSE: Surgical stabilization of rib fractures (SSRF) improves outcomes in certain patient populations. The Chest Wall Injury Society (CWIS) began a new initiative to recognize centers who epitomize their mission as CWIS Collaborative Centers (CWIS-CC). We sought to describe incidence and epidemiology of SSRF at our institutions. METHODS: A retrospective registry evaluation of all patients (age > 15 years) treated at international trauma centers from 1/1/20 to 7/30/2021 was performed...
August 25, 2023: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
#12
JOURNAL ARTICLE
Karim Sahbani, Jiangping Pan, Mone Zaidi, Christopher P Cardozo, William A Bauman, Hesham A Tawfeek
Spinal cord injury (SCI) causes severe and resistant sublesional disuse bone loss. Abaloparatide, a modified parathyroid hormone related peptide, is an FDA approved drug for treatment of severe osteoporosis with potent anabolic activity. The effects of abaloparatide on SCI-induced bone loss remain undefined. Thus, female mice underwent sham or severe contusion thoracic SCI causing hindlimb paralysis. Mice then received subcutaneous injection of vehicle or 20 μg/kg/day abaloparatide for 35 days...
June 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
#13
JOURNAL ARTICLE
Anne Carolyn Grunseit, Eloise Howse, Julie Williams, Adrian Ernest Bauman
BACKGROUND: In Australia, despite the success of tobacco control policy interventions, policymakers remain resistant to policy-based approaches to diet, alcohol, physical inactivity and obesity, concerned about community perceptions of such interventions as "nanny-statist". We examined how people's general positions on government intervention related to their positions on different preventive policy options. METHODS: Data were from a 2018 nationally representative cross-sectional telephone survey of 2601 Australian adults...
April 27, 2023: Healthcare (Basel, Switzerland)
#14
JOURNAL ARTICLE
Christopher M Cirnigliaro, Michael F La Fountaine, Susan J Sauer, Gregory T Cross, Steven C Kirshblum, William A Bauman
CONTEXT/OBJECTIVE: To describe the effect of semaglutide, a glucagon-like peptide-1 (GLP-1) agonist, to reduce body weight and improve glycemic control in overweight or obese individuals with spinal cord injury (SCI). DESIGN: Open-label, randomized drug intervention case series. SETTING: This study was performed at James J. Peters VA Medical Center (JJP VAMC) and Kessler Institute for Rehabilitation (KIR). PARTICIPANTS: Five individuals with chronic SCI meeting criteria for obesity and abnormal carbohydrate metabolism...
May 9, 2023: Journal of Spinal Cord Medicine
#15
JOURNAL ARTICLE
Tracy Nau, William Bellew, Ben J Smith, Adrian Bauman
OBJECTIVES: This study investigated the feasibility of establishing a comprehensive and standardised physical activity surveillance system (PASS) in Australia to guide policy and programs to address this public health priority. METHODS: We gathered information about existing data and reporting obligations in relation to physical activity, by conducting cross-sectoral workshops for each state and territory. This information was synthesised by sector/domain using the socioecological model...
May 4, 2023: Australian and New Zealand Journal of Public Health
#16
JOURNAL ARTICLE
Sara E Cannon, Simon D Donner, Angela Liu, Pedro C González Espinosa, Andrew H Baird, Julia K Baum, Andrew G Bauman, Maria Beger, Cassandra E Benkwitt, Matthew J Birt, Yannick Chancerelle, Joshua E Cinner, Nicole L Crane, Vianney Denis, Martial Depczynski, Nur Fadli, Douglas Fenner, Christopher J Fulton, Yimnang Golbuu, Nicholas A J Graham, James Guest, Hugo B Harrison, Jean-Paul A Hobbs, Andrew S Hoey, Thomas H Holmes, Peter Houk, Fraser A Januchowski-Hartley, Jamaluddin Jompa, Chao-Yang Kuo, Gino Valentino Limmon, Yuting V Lin, Timothy R McClanahan, Dominic Muenzel, Michelle J Paddack, Serge Planes, Morgan S Pratchett, Ben Radford, James Davis Reimer, Zoe T Richards, Claire L Ross, John Rulmal, Brigitte Sommer, Gareth J Williams, Shaun K Wilson
Scientists and managers rely on indicator taxa such as coral and macroalgal cover to evaluate the effects of human disturbance on coral reefs, often assuming a universally positive relationship between local human disturbance and macroalgae. Despite evidence that macroalgae respond to local stressors in diverse ways, there have been few efforts to evaluate relationships between specific macroalgae taxa and local human-driven disturbance. Using genus-level monitoring data from 1205 sites in the Indian and Pacific Oceans, we assess whether macroalgae percent cover correlates with local human disturbance while accounting for factors that could obscure or confound relationships...
April 5, 2023: Global Change Biology
#17
JOURNAL ARTICLE
Luis Ortiz Vasquez, Ingrid Lee, Jessica Bart, Christian R Barton, Jennifer Chui, Oriana Tascione, Nina S Kumar, Christopher M Cirnigliaro, Alex T Lombard, Steven C Kirshblum, William A Bauman, John P Handrakis
OBJECTIVE: Spinal cord injury (SCI) interrupts motor, sensory, and autonomic pathways, impairing mobility and increasing heat storage during warm seasonal temperatures due to compromised autonomic control of vasodilation and sweating and recognition of body temperature. Thus, persons with SCI are more vulnerable to hyperthermia and its adverse effects. However, information regarding how persons with SCI perceive warmer seasons and whether thermal discomfort during warmer seasons restricts routine activities remains anecdotal...
April 3, 2023: Journal of Spinal Cord Medicine
#18
RANDOMIZED CONTROLLED TRIAL
Jill M Wecht, Joseph P Weir, Caitlyn G Katzelnick, Trevor A Dyson-Hudson, William A Bauman, Steven C Kirshblum
BACKGROUND: Individuals with spinal cord injury (SCI) above thoracic level-6 (T6) experience impaired descending cortical control of the autonomic nervous system which predisposes them to blood pressure (BP) instability, including includes hypotension, orthostatic hypotension (OH), and autonomic dysreflexia (AD). However, many individuals do not report symptoms of these BP disorders, and because there are few treatment options that have been proven safe and effective for use in the SCI population, most individuals remain untreated...
July 2023: Journal of Spinal Cord Medicine
#19
JOURNAL ARTICLE
Abdurrahman Aslan, Lauren Harlow, Xin-Hua Liu, Rita De Gasperi, William A Bauman, Marco Brotto, Christopher P Cardozo
Skeletal muscle undergoes rapid and extensive atrophy following nerve transection though the underlying mechanisms remain incompletely understood. We previously showed transiently elevated Notch 1 signaling in denervated skeletal muscle that was abrogated by administration of nandrolone (an anabolic steroid) combined with replacement doses of testosterone. Numb is an adaptor molecule present in myogenic precursors and skeletal muscle fibers that is vital for normal tissue repair after muscle injury and for skeletal muscle contractile function...
2023: International Journal of Medical Sciences
#20
JOURNAL ARTICLE
Vishnu D Chandran, Sanghyun Nam, David Hexner, William A Bauman, Saikat Pal
Robotic exoskeletons have considerable, but largely untapped, potential to restore mobility in individuals with neurological disorders, and other conditions that result in partial or complete immobilization. The growing demand for these devices necessitates the development of technology to characterize the human-robot system during exoskeletal-assisted locomotion (EAL) and accelerate robot design refinements. The goal of this study was to combine controlled experiments with computational modeling to build a virtual simulator of EAL...
2023: PloS One
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