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https://www.readbyqxmd.com/read/27907012/the-signature-of-microrna-dysregulation-in-muscle-paralyzed-by-spinal-cord-injury-includes-downregulation-of-micrornas-that-target-myostatin-signaling
#1
Rita De Gasperi, Zachary A Graham, Lauren M Harlow, William A Bauman, Weiping Qin, Christopher P Cardozo
Spinal cord injury (SCI) results in muscle atrophy, reduced force generation and an oxidative-to-glycolytic fiber type shift. The mechanisms responsible for these alterations remain incompletely understood. To gain new insights regarding mechanisms involved in deterioration of muscle after SCI, global expression profiles of miRs in paralyzed gastrocnemius muscle were compared between sham-operated (Sham) and spinal cord-transected (SCI) rats. Ingenuity Pathways Analysis of the altered miRs identified signaling via insulin, IGF-1, integrins and TGF-β as being significantly enriched for target genes...
2016: PloS One
https://www.readbyqxmd.com/read/27906454/immunotherapy-of-head-and-neck-cancer-emerging-clinical-trials-from-a-national-cancer-institute-head-and-neck-cancer-steering-committee-planning-meeting
#2
Julie E Bauman, Ezra Cohen, Robert L Ferris, David J Adelstein, David M Brizel, John A Ridge, Brian O'Sullivan, Barbara A Burtness, Lisa H Butterfield, William E Carson, Mary L Disis, Bernard A Fox, Thomas F Gajewski, Maura L Gillison, James W Hodge, Quynh-Thu Le, David Raben, Scott E Strome, Jean Lynn, Shakun Malik
Recent advances have permitted successful therapeutic targeting of the immune system in head and neck squamous cell carcinoma (HNSCC). These new immunotherapeutic targets and agents are being rapidly adopted by the oncologic community and hold considerable promise. The National Cancer Institute sponsored a Clinical Trials Planning Meeting to address the issue of how to further investigate the use of immunotherapy in patients with HNSCC. The goals of the meeting were to consider phase 2 or 3 trial designs primarily in 3 different patient populations: those with previously untreated, human papillomavirus-initiated oropharyngeal cancers; those with previously untreated, human papillomavirus-negative HNSCC; and those with recurrent/metastatic HNSCC...
December 1, 2016: Cancer
https://www.readbyqxmd.com/read/27892841/impact-of-the-swap-it-don-t-stop-it-australian-national-mass-media-campaign-on-promoting-small-changes-to-lifestyle-behaviors
#3
Blythe J O'Hara, Anne Grunseit, Philayrath Phongsavan, William Bellew, Megan Briggs, Adrian E Bauman
Mass media campaigns aimed at influencing lifestyle risk factors are one way that governments are attempting to address chronic disease risk. In Australia, a national campaign aimed at encouraging Australians to make changes in lifestyle-related behaviors was implemented from 2008 to 2011. The first phase, Measure Up (2008-2009), focused on why lifestyle changes are needed by increasing awareness of the link between waist circumference and chronic disease risk. The second phase, Swap It, Don't Stop It (2011), emphasized how adults can change their behaviors...
November 28, 2016: Journal of Health Communication
https://www.readbyqxmd.com/read/27808011/bronchodilator-effects-of-ipratropium-bromide-and-albuterol-sulfate-among-subjects-with-tetraplegia
#4
Gregory J Schilero, Joshua C Hobson, Kamaldeep Singh, Ann M Spungen, William A Bauman, Miroslav Radulovic
OBJECTIVE: In addition to lung volume restriction, persons with chronic tetraplegia demonstrate obstructive airway physiology evinced by pharmacologically-induced bronchodilation. We previously found independent evidence that anticholinergic agents (ipratropium bromide; IB) and beta-2 adrenergic agonists (albuterol sulfate; AS) were associated with significant bronchodilation in subjects with tetraplegia as determined via spirometry or body plethysmography. Direct comparison of these two classes of agents has received little attention...
November 3, 2016: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/27735783/abundance-in-proteins-expressed-after-functional-electrical-stimulation-cycling-or-arm-cycling-ergometry-training-in-persons-with-chronic-spinal-cord-injury
#5
Ashraf S Gorgey, Zachary A Graham, William A Bauman, Christopher Cardozo, David R Gater
STUDY DESIGN: Longitudinal design. OBJECTIVES: The study determined the effects of two forms of exercise training on the abundance of two proteins, (glucose transporter-4 [GLUT-4], adenosine monophosphate kinase [AMPK]) involved in glucose utilization and the transcriptional coactivator that regulates the genes involved in energy metabolism and mitochondrial biogenesis (peroxisome proliferator-activated receptor (PPAR) coactivator 1 alpha [PGC-1α]), in muscles in men with chronic motor-complete spinal cord injury (SCI)...
October 13, 2016: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/27599331/screening-for-latent-tuberculosis-infection-in-adults-us-preventive-services-task-force-recommendation-statement
#6
COMMENT
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Linda Bauman, Karina W Davidson, John W Epling, Francisco A R García, Jessica Herzstein, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael P Pignone
IMPORTANCE: Tuberculosis remains an important preventable disease in the United States. An effective strategy for reducing the transmission, morbidity, and mortality of active disease is the identification and treatment of latent tuberculosis infection (LTBI) to prevent progression to active disease. OBJECTIVE: To issue a current US Preventive Services Task Force (USPSTF) recommendation on screening for LTBI. EVIDENCE REVIEW: The USPSTF reviewed the evidence on screening for LTBI in asymptomatic adults seen in primary care, including evidence dating from the inception of searched databases...
September 6, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27531873/association-of-pretreatment-body-mass-index-and-survival-in-human-papillomavirus-positive-oropharyngeal-squamous-cell-carcinoma
#7
William G Albergotti, Kara S Davis, Shira Abberbock, Julie E Bauman, James Ohr, David A Clump, Dwight E Heron, Umamaheswar Duvvuri, Seungwon Kim, Jonas T Johnson, Robert L Ferris
BACKGROUND: Pretreatment body mass index (BMI) >25kg/m(2) is a positive prognostic factor in patients with head and neck cancer. Previous studies have not been adequately stratified by human papilloma virus (HPV) status or subsite. Our objective is to determine prognostic significance of pretreatment BMI on overall survival in HPV+ oropharyngeal squamous cell carcinoma (OPSCC). METHODS: This is a retrospective review of patients with HPV+ OPSCC treated between 8/1/2006 and 8/31/2014...
September 2016: Oral Oncology
https://www.readbyqxmd.com/read/27379604/subsets-of-salivary-duct-carcinoma-defined-by-morphologic-evidence-of-pleomorphic-adenoma-plag1-or-hmga2-rearrangements-and-common-genetic-alterations
#8
Simion I Chiosea, Lester D R Thompson, Ilan Weinreb, Julie E Bauman, Alyssa M Mahaffey, Caitlyn Miller, Robert L Ferris, William E Gooding
BACKGROUND: The authors hypothesized that histogenetic classification of salivary duct carcinoma (SDC) could account for de novo tumors and those with morphologic or molecular evidence (pleomorphic adenoma gene 1 [PLAG1], high-mobility group AT hook 2 [HMGA2] rearrangement, amplification) of pleomorphic adenoma (PA). METHODS: SDCs (n = 66) were reviewed for morphologic evidence of PA. PLAG1 and HMGA2 alterations were detected by fluorescence in situ hybridization (FISH)...
October 15, 2016: Cancer
https://www.readbyqxmd.com/read/27377772/sclerostin-antibody-preserves-the-morphology-and-structure-of-osteocytes-and-blocks-the-severe-skeletal-deterioration-after-motor-complete-spinal-cord-injury-in-rats
#9
Weiping Qin, Xiaodong Li, Yuanzhen Peng, Lauren M Harlow, Yinshi Ren, Yingjie Wu, Jiliang Li, Yiwen Qin, Jie Sun, Shijia Zheng, Tom Brown, Jian Q Feng, Hua Zhu Ke, William A Bauman, Christopher P Cardozo
No abstract text is available yet for this article.
July 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27373743/difficulty-in-identifying-factors-responsible-for-pressure-ulcer-healing-in-veterans-with-spinal-cord-injury
#10
Marylou Guihan, Min-Woong Sohn, William A Bauman, Ann M Spungen, Gail M Powell-Cope, Susan S Thomason, Joseph F Collins, Barbara M Bates-Jensen
OBJECTIVE: To identify characteristics associated with pressure ulcer (PrU) healing for individuals with spinal cord injury (SCI). DESIGN: Secondary analysis of a large clinical trial's data for healing PrUs in individuals with SCI; prospective Delphi process was conducted with SCI and/or PrU experts. SETTING: Spinal cord injury centers. PARTICIPANTS: There were 629 screening and 162 treatment participants (N=791); 185 SCI clinicians/national PrU/wound care experts participated in the Delphi process...
December 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27361552/autonomic-responses-to-orthostasis-after-acetylcholinesterase-inhibition-in-tetraplegia-2983-board-48-june-3-3-30-pm-5-00-pm
#11
Jill M Wecht, Christopher M Cirnigliaro, Frank Azarelo, Alexander T Lombard, William A Bauman, Steven C Kirshblum
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27360358/functional-hepatic-sympathetic-innervation-determines-circulating-triglyceride-rich-lipoprotein-concentrations-in-persons-with-spinal-cord-injury-1439-board-92-june-2-9-00-am-10-30-am
#12
Michael F La Fountaine, Christopher M Cirnigliaro, Steven C Kirshblum, Ann M Spungen, William A Bauman
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27259391/the-assessment-of-blood-loss-during-total-knee-arthroplasty-when-comparing-intravenous-vs-intracapsular-administration-of-tranexamic-acid
#13
Jedediah H May, Geoffrey R Rieser, Chad G Williams, Ronald J Markert, Ryan D Bauman, Matthew W Lawless
BACKGROUND: Administration of tranexamic acid topically and intravenously has demonstrated effectiveness in decreasing blood loss and transfusion rates. METHODS: We randomized 131 patients undergoing primary total knee arthroplasty to receive either intracapsular (69) or intravenous tranexamic acid (62). Postoperative blood loss was calculated using the formula derived by Nadler et al. The number of units transfused was recorded, as well as length of hospital stay...
April 30, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27232378/phase-ii-trial-of-everolimus-in-patients-with-previously-treated-recurrent-or-metastatic-head-and-neck-squamous-cell-carcinoma
#14
Jessica L Geiger, Julie E Bauman, Michael K Gibson, William E Gooding, Prakash Varadarajan, Athanasios Kotsakis, Daniel Martin, Jorge Silvio Gutkind, Matthew L Hedberg, Jennifer R Grandis, Athanassios Argiris
BACKGROUND: Patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) demonstrate aberrant activation of the phosphotidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway. We examined the efficacy of everolimus, an mTOR inhibitor, in patients with recurrent or metastatic HNSCC. METHODS: This single-arm phase II study enrolled biomarker-unselected patients with recurrent or metastatic HNSCC who failed at least 1 prior therapy...
December 2016: Head & Neck
https://www.readbyqxmd.com/read/27220593/pulmonary-artery-pressure-guided-heart-failure-management-reduces-30-day-readmissions
#15
Philip B Adamson, William T Abraham, Lynne Warner Stevenson, Akshay S Desai, JoAnn Lindenfeld, Robert C Bourge, Jordan Bauman
BACKGROUND: This study examines the impact of pulmonary artery pressure-guided heart failure (HF) care on 30-day readmissions in Medicare-eligible patients. METHODS AND RESULTS: The CardioMicroelectromechanical system (CardioMEMS) Heart Sensor Allows Monitoring of Pressures to Improve Outcomes in New York Heart Association Class III Heart Failure Patients (CHAMPION) Trial included 550 patients implanted with a permanent MEMS-based pressure sensor in the pulmonary artery...
June 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27167094/quantitation-of-protein-expression-and-co-localization-using-multiplexed-immuno-histochemical-staining-and-multispectral-imaging
#16
Tyler M Bauman, Emily A Ricke, Sally A Drew, Wei Huang, William A Ricke
Immunohistochemistry is a commonly used clinical and research lab detection technique for investigating protein expression and localization within tissues. Many semi-quantitative systems have been developed for scoring expression using immunohistochemistry, but inherent subjectivity limits reproducibility and accuracy of results. Furthermore, the investigation of spatially overlapping biomarkers such as nuclear transcription factors is difficult with current immunohistochemistry techniques. We have developed and optimized a system for simultaneous investigation of multiple proteins using high throughput methods of multiplexed immunohistochemistry and multispectral imaging...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27157372/long-term-oncologic-outcomes-of-salvage-cryoablation-for-radio-recurrent-prostate-cancer
#17
Khurram M Siddiqui, Michele Billia, Ali Al-Zahrani, Andrew Williams, Christopher Goodman, Andrew Arifin, Philippe Violette, Glenn Bauman, Joseph L Chin
PURPOSE: Management of localized radio-recurrent prostate cancer is not standardized, partly due to the absence of long-term data on oncologic control and the toxicity of various treatment modalities. We analyzed the long-term oncologic outcomes and morbidity of salvage cryoablation for radio-recurrent prostate cancer. MATERIALS AND METHODS: Patients undergoing salvage cryoablation for biopsy proven, localized radio-recurrent prostate cancer from 1995 to 2004 were prospectively accrued...
October 2016: Journal of Urology
https://www.readbyqxmd.com/read/27077570/self-reported-effects-of-cold-temperature-exposure-in-persons-with-tetraplegia
#18
John P Handrakis, Dwindally Rosado-Rivera, Kamaldeep Singh, Kirsten Swonger, Frank Azarelo, Alex T Lombard, Ann M Spungen, Steven C Kirshblum, William A Bauman
OBJECTIVE: Cervical spinal cord injury (tetraplegia) is known to interrupt sympathetic vasculature control, thereby preventing shunting of blood from the periphery to central organs when exposed to cold temperatures. As a result, persons with tetraplegia are at risk to develop hypothermia. However, information regarding the discomfort experienced during the cooler months (late fall, winter, early spring) is overwhelmingly anecdotal. It is not known, with any certainty, how those with tetraplegia perceive cold and if discomfort in colder environments restricts them from performing activities that they routinely would perform...
March 8, 2016: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/27067790/expression-and-colocalization-of-%C3%AE-catenin-and-lymphoid-enhancing-factor-1-in-prostate-cancer-progression
#19
Tyler M Bauman, Chad M Vezina, Emily A Ricke, Richard B Halberg, Wei Huang, Richard E Peterson, William A Ricke
The purpose of this study was to objectively investigate β-catenin and LEF1 abundance, subcellular localization, and colocalization across benign and staged prostate cancer (PCa) specimens. A tissue microarray containing tumor-adjacent histologically benign prostate tissue (BPT; n = 48 patients), high-grade prostatic intraepithelial neoplasia (HGPIN; n = 25), localized PCa (n = 42), aggressive PCa (n = 31), and metastases (n = 22) was stained using multiplexed immunohistochemistry with antibodies toward E-cadherin, β-catenin, and LEF1...
May 2016: Human Pathology
https://www.readbyqxmd.com/read/27035818/genetic-landscape-of-metastatic-and-recurrent-head-and-neck-squamous-cell-carcinoma
#20
Matthew L Hedberg, Gerald Goh, Simion I Chiosea, Julie E Bauman, Maria L Freilino, Yan Zeng, Lin Wang, Brenda B Diergaarde, William E Gooding, Vivian W Y Lui, Roy S Herbst, Richard P Lifton, Jennifer R Grandis
No abstract text is available yet for this article.
April 1, 2016: Journal of Clinical Investigation
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