Djenet Bousbaine, Katherine D Bauman, Y Erin Chen, Victor K Yu, Pranav V Lalgudi, Arash Naziripour, Alessandra Veinbachs, Jennie L Phung, Tam T D Nguyen, Joyce M Swenson, Yue E Lee, Alex Dimas, Sunit Jain, Xiandong Meng, Thi Phuong Thao Pham, Aishan Zhao, Layla Barkal, Inta Gribonika, Koen K A Van Rompay, Yasmine Belkaid, Christopher O Barnes, Michael A Fischbach
The ubiquitous skin colonist Staphylococcus epidermidis elicits a CD8 + T cell response pre-emptively, in the absence of an infection 1 . However, the scope and purpose of this anti-commensal immune program are not well defined, limiting our ability to harness it therapeutically. Here, we show that this colonist also induces a potent, durable, and specific antibody response that is conserved in humans and non-human primates. A series of S. epidermidis cell-wall mutants revealed that the cell surface protein Aap is a predominant target...
January 23, 2024: bioRxiv