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https://www.readbyqxmd.com/read/27907012/the-signature-of-microrna-dysregulation-in-muscle-paralyzed-by-spinal-cord-injury-includes-downregulation-of-micrornas-that-target-myostatin-signaling
#1
Rita De Gasperi, Zachary A Graham, Lauren M Harlow, William A Bauman, Weiping Qin, Christopher P Cardozo
Spinal cord injury (SCI) results in muscle atrophy, reduced force generation and an oxidative-to-glycolytic fiber type shift. The mechanisms responsible for these alterations remain incompletely understood. To gain new insights regarding mechanisms involved in deterioration of muscle after SCI, global expression profiles of miRs in paralyzed gastrocnemius muscle were compared between sham-operated (Sham) and spinal cord-transected (SCI) rats. Ingenuity Pathways Analysis of the altered miRs identified signaling via insulin, IGF-1, integrins and TGF-β as being significantly enriched for target genes...
2016: PloS One
https://www.readbyqxmd.com/read/27906454/immunotherapy-of-head-and-neck-cancer-emerging-clinical-trials-from-a-national-cancer-institute-head-and-neck-cancer-steering-committee-planning-meeting
#2
Julie E Bauman, Ezra Cohen, Robert L Ferris, David J Adelstein, David M Brizel, John A Ridge, Brian O'Sullivan, Barbara A Burtness, Lisa H Butterfield, William E Carson, Mary L Disis, Bernard A Fox, Thomas F Gajewski, Maura L Gillison, James W Hodge, Quynh-Thu Le, David Raben, Scott E Strome, Jean Lynn, Shakun Malik
Recent advances have permitted successful therapeutic targeting of the immune system in head and neck squamous cell carcinoma (HNSCC). These new immunotherapeutic targets and agents are being rapidly adopted by the oncologic community and hold considerable promise. The National Cancer Institute sponsored a Clinical Trials Planning Meeting to address the issue of how to further investigate the use of immunotherapy in patients with HNSCC. The goals of the meeting were to consider phase 2 or 3 trial designs primarily in 3 different patient populations: those with previously untreated, human papillomavirus-initiated oropharyngeal cancers; those with previously untreated, human papillomavirus-negative HNSCC; and those with recurrent/metastatic HNSCC...
December 1, 2016: Cancer
https://www.readbyqxmd.com/read/27897036/computed-tomography-and-magnetic-resonance-findings-of-fat-poor-angiomyolipomas
#3
Aaron Potretzke, Theodora A Potretzke, Tyler Marques Bauman, B Alexander Knight, Alyssa Park, Jonathan M Mobley, Robert S Figenshau, Cary Siegel
INTRODUCTION: Approximately 5% of angiomyolipomas (AMLs) are classified as "fat poor" due to lack of visually detectable fat on imaging, making them difficult to distinguish from renal cell carcinoma. Recent investigations have proposed computed tomography (CT) and magnetic resonance (MR) imaging features suggestive of fat-poor AML (fp-AML). Herein, we determined the frequency of these features in a cohort of fp-AMLs by retrospective review of preoperative imaging. METHODS: A pathology database query from January 2005 to August 2013 identified 49 renal specimens of AML with available imaging...
November 29, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27895075/associations-of-specific-types-of-sports-and-exercise-with-all-cause-and-cardiovascular-disease-mortality-a-cohort-study-of-80%C3%A2-306-british-adults
#4
Pekka Oja, Paul Kelly, Zeljko Pedisic, Sylvia Titze, Adrian Bauman, Charlie Foster, Mark Hamer, Melvyn Hillsdon, Emmanuel Stamatakis
BACKGROUND/AIM: Evidence for the long-term health effects of specific sport disciplines is scarce. Therefore, we examined the associations of six different types of sport/exercise with all-cause and cardiovascular disease (CVD) mortality risk in a large pooled Scottish and English population-based cohort. METHODS: Cox proportional hazards regression was used to investigate the associations between each exposure and all-cause and CVD mortality with adjustment for potential confounders in 80 306 individuals (54% women; mean±SD age: 52±14 years)...
November 28, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27892841/impact-of-the-swap-it-don-t-stop-it-australian-national-mass-media-campaign-on-promoting-small-changes-to-lifestyle-behaviors
#5
Blythe J O'Hara, Anne Grunseit, Philayrath Phongsavan, William Bellew, Megan Briggs, Adrian E Bauman
Mass media campaigns aimed at influencing lifestyle risk factors are one way that governments are attempting to address chronic disease risk. In Australia, a national campaign aimed at encouraging Australians to make changes in lifestyle-related behaviors was implemented from 2008 to 2011. The first phase, Measure Up (2008-2009), focused on why lifestyle changes are needed by increasing awareness of the link between waist circumference and chronic disease risk. The second phase, Swap It, Don't Stop It (2011), emphasized how adults can change their behaviors...
November 28, 2016: Journal of Health Communication
https://www.readbyqxmd.com/read/27889075/abundance-and-composition-of-juvenile-corals-reveals-divergent-trajectories-for-coral-assemblages-across-the-united-arab-emirates
#6
Morgan S Pratchett, Andrew H Baird, Andrew G Bauman, John A Burt
Marked shifts in the composition of coral assemblages are occurring at many locations, but it is unknown whether these are permanent shifts reinforced by patterns of population replenishment. This study examined the composition of juvenile coral assemblages across the United Arab Emirates (UAE). Densities of juvenile corals varied significantly among locations, but were highest where coral cover was highest. Juvenile coral assemblages within the Persian Gulf were dominated by Porites, while no Acropora were recorded...
November 23, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27876552/long-term-altered-immune-responses-following-fetal-priming-in-a-non-human-primate-model-of-maternal-immune-activation
#7
Destanie R Rose, Milo Careaga, Judy Van de Water, Kim McAllister, Melissa D Bauman, Paul Ashwood
Infection during pregnancy can lead to activation of the maternal immune system and has been associated with an increased risk of having an offspring later diagnosed with a neurodevelopmental disorders (NDD) such as autism spectrum disorder (ASD) or Schizophrenia (SZ). Most maternal immune activation (MIA) studies to date have been in rodents and usually involve the use of lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C). However, since NDD are based on behavioral changes, a model of MIA in non-human primates could potentially provide data that helps illuminate complex behavioral and immune outputs in human NDD...
November 19, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27872873/postediting-prostate-magnetic-resonance-imaging-segmentation-consistency-and-operator-time-using-manual-and-computer-assisted-segmentation-multiobserver-study
#8
Maysam Shahedi, Derek W Cool, Cesare Romagnoli, Glenn S Bauman, Matthew Bastian-Jordan, George Rodrigues, Belal Ahmad, Michael Lock, Aaron Fenster, Aaron D Ward
Prostate segmentation on T2w MRI is important for several diagnostic and therapeutic procedures for prostate cancer. Manual segmentation is time-consuming, labor-intensive, and subject to high interobserver variability. This study investigated the suitability of computer-assisted segmentation algorithms for clinical translation, based on measurements of interoperator variability and measurements of the editing time required to yield clinically acceptable segmentations. A multioperator pilot study was performed under three pre- and postediting conditions: manual, semiautomatic, and automatic segmentation...
October 2016: Journal of Medical Imaging
https://www.readbyqxmd.com/read/27871537/-1-8-million-and-counting-how-volatile-agent-education-has-decreased-our-spending-1000-per-day
#9
Scott A Miller, Carol A Aschenbrenner, Justin R Traunero, Loren A Bauman, Samuel S Lobell, Jeffrey S Kelly, John E Reynolds
STUDY OBJECTIVE: Volatile anesthetic agents comprise a substantial portion of every hospital's pharmacy budget. Challenged with an initiative to lower anesthetic drug expenditures, we developed an education-based intervention focused on reducing volatile anesthetic costs while preserving access to all available volatile anesthetics. When postintervention evaluation demonstrated a dramatic year-over-year reduction in volatile agent acquisition costs, we undertook a retrospective analysis of volatile anesthetic purchasing data using time series analysis to determine the impact of our educational initiative...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27856994/nurse-educators-occupational-and-leisure-sitting-time
#10
Lizbeth P Sturgeon, Dawn Garrett-Wright, Eve Main, Donna Blackburn, M Susan Jones
Prolonged sitting time (ST) is a risk factor for all-cause mortality, independent of physical activity. Nurse educators are particularly at risk due to limited physical activity, older age, and the increasing use of computers. This descriptive correlational study was designed to explore the ST of nurse educators in relation to their self-reported health status and general health indicators. A convenience sample of 56 nurse educators was recruited, and participants completed demographic items, general health questions, and the Workforce Sitting Questionnaire (WSQ; Chau, van der Ploeg, Dunn, Kurko, & Bauman, 2011)...
November 17, 2016: Workplace Health & Safety
https://www.readbyqxmd.com/read/27847915/is-extended-preoperative-antibiotic-prophylaxis-for-high-risk-patients-necessary-before-percutaneous-nephrolithotomy
#11
Aaron M Potretzke, Alyssa M Park, Tyler M Bauman, Jeffrey A Larson, Joel M Vetter, Brian M Benway, Alana C Desai
PURPOSE: The goal of this study was to compare the rate of systemic inflammatory response syndrome (SIRS) in high-risk patients undergoing percutaneous nephrolithotomy (PCNL) between patients who received 7, 2, or 0 days of preoperative antibiotics. MATERIALS AND METHODS: We retrospectively reviewed a series of consecutive PCNLs performed at our institution. Patients with infected preoperative urine cultures were excluded. High-risk patients were defined as those with a history of previous urinary tract infection (UTI), hydronephrosis, or stone size ≥2 cm...
November 2016: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/27847388/30-year-trends-in-overweight-obesity-and-waist-to-height-ratio-by-socioeconomic-status-in-australian-children-1985-to-2015
#12
L L Hardy, S Mihrshahi, J Gale, B A Drayton, A Bauman, J Mitchell
BACKGROUND/OBJECTIVE: To report 30-year (1985-2015) prevalence trends in overweight, obesity and abdominal obesity among children by school level and socioeconomic status (SES). SUBJECTS/METHODS: Five cross-sectional, population child surveys (age 4-18 years; n=27 808) conducted in 1985-1997-2004-2010-2015 in New South Wales, Australia. Outcomes were prevalence of measured overweight, obesity, and waist-to-height ratio (WHtR⩾0.5) by sex, school level (children [primary] and adolescents [high]) and SES tertile...
November 16, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27824083/27-years-of-benthic-and-coral-community-dynamics-on-turbid-highly-urbanised-reefs-off-singapore
#13
J R Guest, K Tun, J Low, A Vergés, E M Marzinelli, A H Campbell, A G Bauman, D A Feary, L M Chou, P D Steinberg
Coral cover on reefs is declining globally due to coastal development, overfishing and climate change. Reefs isolated from direct human influence can recover from natural acute disturbances, but little is known about long term recovery of reefs experiencing chronic human disturbances. Here we investigate responses to acute bleaching disturbances on turbid reefs off Singapore, at two depths over a period of 27 years. Coral cover declined and there were marked changes in coral and benthic community structure during the first decade of monitoring at both depths...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27818304/improved-confidence-in-performing-nutrition-and-physical-activity-behaviours-mediates-behavioural-change-in-young-adults-mediation-results-of-a-randomised-controlled-mhealth-intervention
#14
Stephanie R Partridge, Kevin McGeechan, Adrian Bauman, Philayrath Phongsavan, Margaret Allman-Farinelli
BACKGROUND: The burden of weight gain disproportionally affects young adults. Understanding the underlying behavioural mechanisms of change in mHealth nutrition and physical activity interventions designed for young adults is important for enhancing and translating effective interventions. PURPOSE: First, we hypothesised that knowledge, self-efficacy and stage-of-change for nutrition and physical activity behaviours would improve, and second, that self-efficacy changes in nutrition and physical activity behaviours mediate the behaviour changes observed in an mHealth RCT for prevention of weight gain...
November 4, 2016: Appetite
https://www.readbyqxmd.com/read/27808011/bronchodilator-effects-of-ipratropium-bromide-and-albuterol-sulfate-among-subjects-with-tetraplegia
#15
Gregory J Schilero, Joshua C Hobson, Kamaldeep Singh, Ann M Spungen, William A Bauman, Miroslav Radulovic
OBJECTIVE: In addition to lung volume restriction, persons with chronic tetraplegia demonstrate obstructive airway physiology evinced by pharmacologically-induced bronchodilation. We previously found independent evidence that anticholinergic agents (ipratropium bromide; IB) and beta-2 adrenergic agonists (albuterol sulfate; AS) were associated with significant bronchodilation in subjects with tetraplegia as determined via spirometry or body plethysmography. Direct comparison of these two classes of agents has received little attention...
November 3, 2016: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/27805990/improving-mortality-in-trauma-laparotomy-through-the-evolution-of-damage-control-resuscitation-analysis-of-1-030-consecutive-trauma-laparotomies
#16
Bellal Joseph, Asad Azim, Bardiya Zangbar, Zachary M Bauman, Terence O'Keeffe, Kareem Ibraheem, Narong Kulvatunyou, Andrew Tang, Rifat Latifi, Peter Rhee
BACKGROUND: The aim of this study was to evaluate the related change in outcomes (mortality, complications) in patients undergoing trauma laparotomy (TL) with implementation of damage control resuscitation (DCR). We hypothesized that implementation of DCR in patients undergoing TL is associated with better outcomes. METHODS: We analyzed 1030 consecutive patients with TL. Patients were stratified into 3 phases: Pre-DCR (2006-2007), transient (2008-2009), and post-DCR (2010-2013)...
October 31, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27795399/antibody-based-therapy-for-enterococcal-catheter-associated-urinary-tract-infections
#17
Ana L Flores-Mireles, Jennifer N Walker, Aaron Potretzke, Henry L Schreiber, Jerome S Pinkner, Tyler M Bauman, Alyssa M Park, Alana Desai, Scott J Hultgren, Michael G Caparon
: Gram-positive bacteria in the genus Enterococcus are a frequent cause of catheter-associated urinary tract infection (CAUTI), a disease whose treatment is increasingly challenged by multiantibiotic-resistant strains. We have recently shown that E. faecalis uses the Ebp pilus, a heteropolymeric surface fiber, to bind the host protein fibrinogen as a critical step in CAUTI pathogenesis. Fibrinogen is deposited on catheters due to catheter-induced inflammation and is recognized by the N-terminal domain of EbpA (EbpA(NTD)), the Ebp pilus's adhesin...
October 25, 2016: MBio
https://www.readbyqxmd.com/read/27791347/discovery-of-a-novel-jak3-selective-inhibitor-functional-differentiation-of-jak3-selective-inhibition-over-pan-jak-or-jak1-selective-inhibition
#18
Jean-Baptiste Telliez, Martin E Dowty, Lu Wang, Jason Jussif, Tsung Lin, Li Li, Erick Moy, Paul Balbo, Wei Li, Yajuan Zhao, Kimberly Crouse, Caitlyn Dickinson, Peter Symanowicz, Martin Hegen, Mary Ellen Banker, Fabien Vincent, Ray Unwalla, Sidney Liang, Adam M Gilbert, Matthew F Brown, Matthew Hayward, Justin Montgomery, Xin Yang, Jonathan Bauman, John I Trujillo, Agustin Casimiro-Garcia, Felix F Vajdos, Louis Leung, Kieran F Geoghegan, Amira Quazi, Dejun Xuan, Lyn H Jones, Erik Hett, Katherine Wright, James D Clark, Atli Thorarensen
PF-06651600, a newly discovered potent JAK3-selective inhibitor is highly efficacious at inhibiting γc cytokine signaling which is dependent on both JAK1 and JAK3. PF-06651600 allowed the comparison of JAK3-selective inhibition to pan-JAK or JAK1-selective inhibition, in relevant immune cells to a level that couldn't be achieved previously without such potency and selectivity. In vitro, PF-06651600 inhibits Th1 and Th17 cell differentiation and function, and in vivo it reduces disease pathology in the rat adjuvant-induced arthritis as well as in the mouse experimental autoimmune encephalomyelitis models...
October 28, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/27775467/effects-of-distant-green-space-on-physical-activity-in-sydney-australia
#19
Shanley Chong, Roy Byun, Soumya Mazumdar, Adrian Bauman, Bin Jalaludin
BACKGROUND: The aim was to investigate the association between distant green space and physical activity modified by local green space. METHODS: Information about physical activity, demographic and socio-economic background at the individual level was extracted from New South Wales Population Health Survey. The proportion of a postcode that was parkland was used as a proxy measure for access to parklands and was calculated for each individual. RESULTS: There was a significant relationship between distant green space and engaging in moderate to vigorous physical activity (MVPA) at least once a week...
October 24, 2016: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/27774833/outcome-after-pin-fixation-of-supracondylar-humerus-fractures-in-children-postoperative-radiographic-examinations-are-unnecessary
#20
Noora Tuomilehto, Reetta Kivisaari, Antti Sommarhem, Aarno Y Nietosvaara
Background and purpose - The quality of pin fixation of displaced supracondylar humerus fractures in children has not been assessed, and the clinical value of radiographic examinations after pin fixation is unclear. We evaluated pin configuration, quality of osteosynthesis, and outcome in 264 supracondylar fractures. The clinical significance of postoperative radiographs was analyzed. Patients and methods - 252 Gartland-III and 12 flexion-type supracondylar humerus fractures were pin-fixed in the periods 2002-2006 and 2012-2014...
October 24, 2016: Acta Orthopaedica
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