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https://www.readbyqxmd.com/read/28074345/the-beneficial-effects-of-physical-activity-is-it-down-to-your-genes-a-systematic-review-and-meta-analysis-of-twin-and-family-studies
#1
REVIEW
J R Zadro, D Shirley, T B Andrade, K J Scurrah, A Bauman, P H Ferreira
BACKGROUND: There is evidence for considerable heterogeneity in the responsiveness to regular physical activity (PA) which might reflect the influence of genetic factors. The aim of this systematic review was to assess whether the response to a PA intervention for measures of body composition and cardiorespiratory fitness is (i) correlated within twin pairs and/or families and (ii) more correlated in monozygotic twins (MZ) compared to dizygotic twins (DZ), which would be consistent with genetic effects...
December 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28069082/legislation-for-youth-sport-concussion-in-canada-review-conceptual-framework-and-recommendations
#2
Kelly Russell, Michael J Ellis, Shannon Bauman, Charles H Tator
In this article, we conduct a review of introduced and enacted youth concussion legislation in Canada and present a conceptual framework and recommendations for future youth sport concussion laws. We conducted online searches of federal, provincial, and territorial legislatures to identify youth concussion bills that were introduced or successfully enacted into law. Internet searches were carried out from July 26 and 27, 2016. Online searches identified six youth concussion bills that were introduced in provincial legislatures, including two in Ontario and Nova Scotia and one each in British Columbia and Quebec...
January 10, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28068991/multiple-lifestyle-behaviours-and-mortality-findings-from-a-large-population-based-norwegian-cohort-study%C3%A2-the-hunt-study
#3
Steinar Krokstad, Ding Ding, Anne C Grunseit, Erik R Sund, Turid Lingaas Holmen, Vegar Rangul, Adrian Bauman
BACKGROUND: Lifestyle risk behaviours are responsible for a large proportion of disease burden and premature mortality worldwide. Risk behaviours tend to cluster in populations. We developed a new lifestyle risk index by including emerging risk factors (sleep, sitting time, and social participation) and examine unique risk combinations and their associations with all-cause and cardio-metabolic mortality. METHODS: Data are from a large population-based cohort study in a Norway, the Nord-Trøndelag Health Study (HUNT), with an average follow-up time of 14...
January 10, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28068796/partial-nephrectomy-for-presumed-renal-cell-carcinoma-incidence-predictors-and-perioperative-outcomes-of-benign-lesions
#4
Tyler Marques Bauman, Aaron Potretzke, Alec J Wright, Brent Alexander Knight, Joel M Vetter, Robert S Figenshau
BACKGROUND: The aim of this study was to investigate the incidence of benign histology after partial nephrectomy (PN) in patients with presumed malignancy from preoperative imaging. Further, preoperative predictors of benign lesions and perioperative outcomes were also assessed. METHODS: A series of patients undergoing PN for renal masses was identified using a prospectively maintained database. Patients were excluded for known genetic conditions, if more than one renal mass was resected, or if standard preoperative imaging was not suspicious for RCC...
January 9, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28054806/early-amygdala-or-hippocampus-damage-influences-adolescent-female-social-behavior-during-group-formation
#5
Gilda Moadab, Eliza Bliss-Moreau, Melissa D Bauman, David G Amaral
This study continues a longitudinal analysis of rhesus macaque social behavior following bilateral neonatal ibotenic acid lesions of the amygdala or hippocampus, or sham operations. The social behavior of female subjects was evaluated at a critical developmental time point-the transition to adulthood. At approximately 4 years of age, female subjects were housed in small groups with other female subjects and reproductively viable adult males. As compared with neurologically intact control animals and animals with early amygdala damage, animals with early hippocampal damage were more social with their female peers...
January 5, 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28054097/prolonged-sitting-may-increase-diabetes-risk-in-physically-inactive-individuals-an-11%C3%A2-year-follow-up-of-the-hunt-study-norway
#6
Bjørn O Åsvold, Kristian Midthjell, Steinar Krokstad, Vegar Rangul, Adrian Bauman
AIMS/HYPOTHESIS: We examined the association between sitting time and diabetes incidence, overall and by strata of leisure-time physical activity and BMI. METHODS: We followed 28,051 adult participants of the Nord-Trøndelag Health Study (the HUNT Study), a population-based study, for diabetes incidence from 1995-1997 to 2006-2008 and estimated HRs of any diabetes by categories of self-reported total daily sitting time at baseline. RESULTS: Of 28,051 participants, 1253 (4...
January 4, 2017: Diabetologia
https://www.readbyqxmd.com/read/28046370/th-cd-202-09-free-breathing-proton-mri-functional-lung-avoidance-maps-to-guide-radiation-therapy
#7
D Capaldi, K Sheikh, D Hoover, B Yaremko, D Palma, G Parraga
PURPOSE: Pulmonary functional MRI using inhaled gas contrast agents was previously investigated as a way to identify well-functioning lung in patients with NSCLC who are clinical candidates for radiotherapy. Hyperpolarized noble-gas ((3) He and (129) Xe) MRI has also been optimized to measure functional lung information, but for a number of reasons, the clinical translation of this approach to guide radiotherapy planning has been limited. As an alternative, free-breathing pulmonary 1H MRI using clinically available MRI systems and pulse sequences provides a non-contrast-enhanced method to generate both ventilation and perfusion maps...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28040519/vegetarian-diet-and-all-cause-mortality-evidence-from-a-large-population-based-australian-cohort-the-45-and-up-study
#8
Seema Mihrshahi, Ding Ding, Joanne Gale, Margaret Allman-Farinelli, Emily Banks, Adrian E Bauman
The vegetarian diet is thought to have health benefits including reductions in type 2 diabetes, hypertension, and obesity. Evidence to date suggests that vegetarians tend to have lower mortality rates when compared with non-vegetarians, but most studies are not population-based and other healthy lifestyle factors may have confounded apparent protective effects. The aim of this study was to evaluate the association between categories of vegetarian diet (including complete, semi and pesco-vegetarian) and all-cause mortality in a large population-based Australian cohort...
December 29, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/28029303/e1308-phase-ii-trial-of-induction-chemotherapy-followed-by-reduced-dose-radiation-and-weekly-cetuximab-in-patients-with-hpv-associated-resectable-squamous-cell-carcinoma-of-the-oropharynx-ecog-acrin-cancer-research-group
#9
Shanthi Marur, Shuli Li, Anthony J Cmelak, Maura L Gillison, Weiqiang J Zhao, Robert L Ferris, William H Westra, Jill Gilbert, Julie E Bauman, Lynne I Wagner, David R Trevarthen, Jahagirdar Balkrishna, Barbara A Murphy, Nishant Agrawal, A Dimitrios Colevas, Christine H Chung, Barbara Burtness
Purpose Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is treatment-responsive. Definitive chemoradiation results in high cure rates but causes long-term toxicity and may represent overtreatment of some patients. This phase II trial evaluated whether complete clinical response (cCR) to induction chemotherapy (IC) could select patients with HPV-associated OPSCC for reduced radiation dose as a means of sparing late sequelae. Methods Patients with HPV16 and/or p16-positive, stage III-IV OPSCC received three cycles of IC with cisplatin, paclitaxel, and cetuximab...
December 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28017976/acute-abdomen-in-the-17th-week-of-twin-pregnancy-due-to-ovarian-torsion-a-late-complication-of-ivf
#10
D Habek, R Bauman, L Rukavina Kralj, T Hafner, T Turudic, S Vujisic
Background: A 32-year-old woman with tubal factor infertility due to bilateral laparoscopic salpingectomy conceived twins with in vitro fertilization (IVF). She developed moderate ovarian hyperstimulation syndrome which was treated with anticoagulant therapy. The subsequent course of the twin pregnancy was normal until the 17th week of gestation when she presented to hospital because of a sharp pain in the right lower abdomen which ceased after admission. Case: Except for a single incident of vomiting, patient had no other subjective symptoms...
December 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/27998200/spinal-cord-injury-leads-to-hyperoxidation-and-nitrosylation-of-skeletal-muscle-ryanodine-receptor-1-associated-with-upregulation-of-nadh-oxidase-4
#11
Xin-Hua Liu, Lauren Harlow, Zachary A Graham, William A Bauman, Chris Cardozo
Spinal cord injury (SCI) results in marked atrophy and dysfunction of skeletal muscle. There are currently no effective treatments for SCI-induced muscle atrophy or the dysfunction of the remaining muscle tissue. NADPH oxidase-4 (Nox4) produces reactive oxygen species (ROS) in sarcoplasmic reticulum (SR) and has been identified as an important O2 sensor in skeletal muscle. Ryanodine receptors (RyRs) are calcium (Ca2+) channels that are responsible for Ca2+ release from SR. In skeletal muscle, type1 RyR (RyR1) is predominantly functional...
December 21, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27960249/who-is-at-risk-of-chronic-disease-associations-between-risk-profiles-of-physical-activity-sitting-and-cardio-metabolic-disease-in-australian-adults
#12
Lina Engelen, Joanne Gale, Josephine Y Chau, Louise L Hardy, Martin Mackey, Nathan Johnson, Debra Shirley, Adrian Bauman
OBJECTIVE: To examine the associations of physical activity (PA) and sitting time (sit) with cardio-metabolic diseases. METHODS: Cross-sectional data from the Australian National Nutrition and Physical Activity Survey 2011-2012 (n=9,435) were used to classify adults into low and high risk groups based on their physical activity and sitting behaviour profiles. Logistic regression models examined associations between low and high risk classifications (high PA-low sit; high PA-high sit; low PA-low sit; low PA-high sit;) and socio-demographic factors, and associations between low and high risk classifications and the prevalence of cardiovascular disease, Type 2 diabetes and metabolic syndrome...
December 13, 2016: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/27960226/correlates-of-physical-activity-among-australian-indigenous-and-non-indigenous-adolescents
#13
Rona Macniven, Shane Hearn, Anne Grunseit, Justin Richards, Don Nutbeam, Adrian Bauman
OBJECTIVE: Physical inactivity is an important modifiable cause of the excess burden of disease among Indigenous Australians. We describe physical activity patterns and influencing factors, comparing Indigenous and non-Indigenous adolescents. METHODS: Indigenous (n=359) and non-Indigenous (n=637) adolescents aged 13-17 years from disadvantaged New South Wales regions completed a health and lifestyle survey. Socio-demographic, social, psychosocial and health correlates of out of school physical activity (high vs...
December 13, 2016: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/27932450/accuracy-of-diffusion-weighted-magnetic-resonance-colonography-in-assessing-mucosal-healing-and-the-treatment-response-in-patients-with-ulcerative-colitis
#14
Valérie Laurent, Sébastien Naudé, Lucine Vuitton, Camille Zallot, Cédric Bauman, Mélanie Girard-Gavanier, Laurent Peyrin-Biroulet
BACKGROUND & AIMS: Using sigmoidoscopy as the gold standard, we assessed the accuracy and responsiveness to change of diffusion-weighted magnetic resonance colonography in ulcerative colitis using the Nancy score. METHODS: 29 ulcerative colitis patients having undergone at least two diffusion-weighted magnetic resonance colonographies were included. Disease activity was evaluated using the Mayo endoscopic subscore and the Nancy score. We determined the accuracy of the Nancy score in the diagnosis of mucosal healing...
December 7, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27921146/bone-loss-at-the-distal-femur-and-proximal-tibia-in-persons-with-spinal-cord-injury-imaging-approaches-risk-of-fracture-and-potential-treatment-options
#15
REVIEW
C M Cirnigliaro, M J Myslinski, M F La Fountaine, S C Kirshblum, G F Forrest, W A Bauman
Persons with spinal cord injury (SCI) undergo immediate unloading of the skeleton and, as a result, have severe bone loss below the level of lesion associated with increased risk of long-bone fractures. The pattern of bone loss in individuals with SCI differs from other forms of secondary osteoporosis because the skeleton above the level of lesion remains unaffected, while marked bone loss occurs in the regions of neurological impairment. Striking demineralization of the trabecular epiphyses of the distal femur (supracondylar) and proximal tibia occurs, with the knee region being highly vulnerable to fracture because many accidents occur while sitting in a wheelchair, making the knee region the first point of contact to any applied force...
December 5, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27918686/utility-of-surveillance-research-to-inform-physical-activity-policy-an-exemplar-from-canada
#16
Cora L Craig, Christine A Cameron, Adrian Bauman
BACKGROUND: There are several well-known risk factor monitoring systems, but few examples of comprehensive surveillance systems designed specifically to inform physical activity (PA) policy. This paper examines the utility of Canada`s Physical Activity and Sport Monitoring System in guiding policy and practice. METHODS: Indicators were determined in conjunction with government, non-governmental associations and academics. Serial measures were collected from representative population (telephone interviews, n=4,000-11,000) and setting-based (postal surveys, n=1,425-4,304) surveys...
December 5, 2016: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/27907012/the-signature-of-microrna-dysregulation-in-muscle-paralyzed-by-spinal-cord-injury-includes-downregulation-of-micrornas-that-target-myostatin-signaling
#17
Rita De Gasperi, Zachary A Graham, Lauren M Harlow, William A Bauman, Weiping Qin, Christopher P Cardozo
Spinal cord injury (SCI) results in muscle atrophy, reduced force generation and an oxidative-to-glycolytic fiber type shift. The mechanisms responsible for these alterations remain incompletely understood. To gain new insights regarding mechanisms involved in deterioration of muscle after SCI, global expression profiles of miRs in paralyzed gastrocnemius muscle were compared between sham-operated (Sham) and spinal cord-transected (SCI) rats. Ingenuity Pathways Analysis of the altered miRs identified signaling via insulin, IGF-1, integrins and TGF-β as being significantly enriched for target genes...
2016: PloS One
https://www.readbyqxmd.com/read/27906454/immunotherapy-of-head-and-neck-cancer-emerging-clinical-trials-from-a-national-cancer-institute-head-and-neck-cancer-steering-committee-planning-meeting
#18
Julie E Bauman, Ezra Cohen, Robert L Ferris, David J Adelstein, David M Brizel, John A Ridge, Brian O'Sullivan, Barbara A Burtness, Lisa H Butterfield, William E Carson, Mary L Disis, Bernard A Fox, Thomas F Gajewski, Maura L Gillison, James W Hodge, Quynh-Thu Le, David Raben, Scott E Strome, Jean Lynn, Shakun Malik
Recent advances have permitted successful therapeutic targeting of the immune system in head and neck squamous cell carcinoma (HNSCC). These new immunotherapeutic targets and agents are being rapidly adopted by the oncologic community and hold considerable promise. The National Cancer Institute sponsored a Clinical Trials Planning Meeting to address the issue of how to further investigate the use of immunotherapy in patients with HNSCC. The goals of the meeting were to consider phase 2 or 3 trial designs primarily in 3 different patient populations: those with previously untreated, human papillomavirus-initiated oropharyngeal cancers; those with previously untreated, human papillomavirus-negative HNSCC; and those with recurrent/metastatic HNSCC...
December 1, 2016: Cancer
https://www.readbyqxmd.com/read/27897036/computed-tomography-and-magnetic-resonance-findings-of-fat-poor-angiomyolipomas
#19
Aaron M Potretzke, Theodora A Potretzke, Tyler M Bauman, B Alexander Knight, Alyssa M Park, Jonathan M Mobley, Robert Sherburne Figenshau, Cary Lynn Siegel
INTRODUCTION: Approximately 5% of angiomyolipomas (AMLs) are classified as "fat poor" due to lack of visually detectable fat on imaging, making them difficult to distinguish from renal cell carcinoma. Recent investigations have proposed CT and MR imaging features suggestive of fat-poor AML (fp-AML). Herein, we determined the frequency of these features in a cohort of fp-AMLs by retrospective review of preoperative imaging. METHODS: A pathology database query from January 2005 to August 2013 identified 49 renal specimens of AML with available imaging...
January 3, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/27895075/associations-of-specific-types-of-sports-and-exercise-with-all-cause-and-cardiovascular-disease-mortality-a-cohort-study-of-80%C3%A2-306-british-adults
#20
Pekka Oja, Paul Kelly, Zeljko Pedisic, Sylvia Titze, Adrian Bauman, Charlie Foster, Mark Hamer, Melvyn Hillsdon, Emmanuel Stamatakis
BACKGROUND/AIM: Evidence for the long-term health effects of specific sport disciplines is scarce. Therefore, we examined the associations of six different types of sport/exercise with all-cause and cardiovascular disease (CVD) mortality risk in a large pooled Scottish and English population-based cohort. METHODS: Cox proportional hazards regression was used to investigate the associations between each exposure and all-cause and CVD mortality with adjustment for potential confounders in 80 306 individuals (54% women; mean±SD age: 52±14 years)...
November 28, 2016: British Journal of Sports Medicine
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