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https://www.readbyqxmd.com/read/28338881/mdhb1-down-regulation-activates-anthocyanin-biosynthesis-in-the-white-fleshed-apple-cultivar-granny-smith
#1
Yonghua Jiang, Cuihua Liu, Dan Yan, Xiaohong Wen, Yanli Liu, Haojie Wang, Jieyu Dai, Yujie Zhang, Yanfei Liu, Bin Zhou, Xiaolin Ren
Coloration in apple (Malus×domestica) flesh is mainly caused by the accumulation of anthocyanin. Anthocyanin is biosynthesized through the flavonoid pathway and regulated by MYB, bHLH, and WD40 transcription factors (TFs). Here, we report that the HD-Zip I TF MdHB1 was also involved in the regulation of anthocyanin accumulation. MdHB1 silencing caused the accumulation of anthocyanin in 'Granny Smith' flesh, whereas its overexpression reduced the flesh content of anthocyanin in 'Ballerina' (red-fleshed apple)...
March 6, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28338755/red-blotch-disease-alters-grape-berry-development-and-metabolism-by-interfering-with-the-transcriptional-and-hormonal-regulation-of-ripening
#2
Barbara Blanco-Ulate, Helene Hopfer, Rosa Figueroa-Balderas, Zirou Ye, Rosa M Rivero, Alfonso Albacete, Francisco Pérez-Alfocea, Renata Koyama, Michael M Anderson, Rhonda J Smith, Susan E Ebeler, Dario Cantu
Grapevine red blotch-associated virus (GRBaV) is a major threat to the wine industry in the USA. GRBaV infections (aka red blotch disease) compromise crop yield and berry chemical composition, affecting the flavor and aroma properties of must and wine. In this study, we combined genome-wide transcriptional profiling with targeted metabolite analyses and biochemical assays to characterize the impact of the disease on red-skinned berry ripening and metabolism. Using naturally infected berries collected from two vineyards, we were able to identify consistent berry responses to GRBaV across different environmental and cultural conditions...
January 27, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28337518/both-atrbohd-and-atrbohf-are-essential-for-mediating-responses-to-oxygen-deficiency-in-arabidopsis
#3
Bo Liu, Lirong Sun, Liya Ma, Fu-Shun Hao
Both AtrbohD and AtrbohF promote the increases in activities of ADH, PDC, LDH, and Ca(2+) levels, and induce the expression of multiple hypoxia response genes, thus improving Arabidopsis adaptation to oxygen deficiency. NADPH oxidase AtrbohD and AtrbohF cooperatively play key roles in regulation of growth and stress signaling in Arabidopsis. However, reports on AtrbohD and AtrbohF functioning together in hypoxia signaling are scarce, and the underlying mechanisms remain elusive. Here, we show that the double null mutant atrbohD/F is more sensitive to oxygen deprivation compared with wild type (WT) and the single mutant atrbohD and atrbohF...
March 23, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28337212/identification-of-norway-spruce-myb-bhlh-wdr-transcription-factor-complex-members-linked-to-regulation-of-the-flavonoid-pathway
#4
Miguel Nemesio-Gorriz, Peter B Blair, Kerstin Dalman, Almuth Hammerbacher, Jenny Arnerup, Jan Stenlid, Shahid M Mukhtar, Malin Elfstrand
Transcription factors (TFs) forming MYB-bHLH-WDR complexes are known to regulate the biosynthesis of specialized metabolites in angiosperms through an intricate network. These specialized metabolites participate in a wide range of biological processes including plant growth, development, reproduction as well as in plant immunity. Studying the regulation of their biosynthesis is thus essential. While MYB (TFs) have been previously shown to control specialized metabolism (SM) in gymnosperms, the identity of their partners, in particular bHLH or WDR members, has not yet been revealed...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28335521/gene-transformation-induced-changes-in-chemical-functional-group-features-and-molecular-structure-conformation-in-alfalfa-plants-co-expressing-lc-bhlh-and-c1-myb-transcriptive-flavanoid-regulatory-genes-effects-of-single-gene-and-two-gene-insertion
#5
Ravindra G Heendeniya, Peiqiang Yu
Alfalfa (Medicago sativa L.) genotypes transformed with Lc-bHLH and Lc transcription genes were developed with the intention of stimulating proanthocyanidin synthesis in the aerial parts of the plant. To our knowledge, there are no studies on the effect of single-gene and two-gene transformation on chemical functional groups and molecular structure changes in these plants. The objective of this study was to use advanced molecular spectroscopy with multivariate chemometrics to determine chemical functional group intensity and molecular structure changes in alfalfa plants when co-expressing Lc-bHLH and C1-MYB transcriptive flavanoid regulatory genes in comparison with non-transgenic (NT) and AC Grazeland (ACGL) genotypes...
March 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28332727/protective-bcl11a-and-hbs1l-myb-polymorphisms-in-a-cohort-of-102-congolese-patients-suffering-from-sickle-cell-anemia
#6
Tite Minga Mikobi, Prosper Tshilobo Lukusa, Michel Ntetani Aloni, Aimé Zola Lumaka, Didine Kinkodi Kaba, Koenraad Devriendt, Gert Matthijs, Jean Marie Mbuyi Muamba, Valérie Race
BACKGROUND: We aimed to investigate the distribution of selected BCL11A and HMIP polymorphisms (SNP's), and to assess the correlation with HPFH in a cohort of sickle cell patients. METHODS: A preliminary cross-sectional study was conducted in 102 patients. Group 1 was composed of patients with HPFH and Group 2 consisted of patients without HbF. We assessed 8 SNPs previously associated with HPFH in cohorts genetically close to the Congolese population. Observed frequencies were compared to expected frequencies...
March 23, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28332702/the-mtp1-promoters-from-arabidopsis-halleri-reveal-cis-regulating-elements-for-the-evolution-of-metal-tolerance
#7
Elisa Fasani, Giovanni DalCorso, Claudio Varotto, Mingai Li, Giovanna Visioli, Monica Mattarozzi, Antonella Furini
In the hyperaccumulator Arabidopsis halleri, the zinc (Zn) vacuolar transporter MTP1 is a key component of hypertolerance. Because protein sequences and functions are highly conserved between A. halleri and Arabidopsis thaliana, Zn tolerance in A. halleri may reflect the constitutively higher MTP1 expression compared with A. thaliana, based on copy number expansion and different cis regulation. Three MTP1 promoters were characterized in A. halleri ecotype I16. The comparison with the A. thaliana MTP1 promoter revealed different expression profiles correlated with specific cis-acting regulatory elements...
March 23, 2017: New Phytologist
https://www.readbyqxmd.com/read/28331227/zdhhc11-and-zdhhc11b-are-critical-novel-components-of-the-oncogenic-myc-mir-150-myb-network-in-burkitt-lymphoma
#8
A Dzikiewicz-Krawczyk, K Kok, I Slezak-Prochazka, J-L Robertus, J Bruining, M M Tayari, B Rutgers, D de Jong, J Koerts, A Seitz, J Li, B Tillema, J E Guikema, I M Nolte, A Diepstra, L Visser, J Kluiver, A van den Berg
Leukemia accepted article preview online, 23 March 2017. doi:10.1038/leu.2017.94.
March 23, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28330872/nadph-oxidase-1-supports-proliferation-of-colon-cancer-cells-by-modulating-reactive-oxygen-species-dependent-signal-transduction
#9
Agnes Juhasz, Susan Markel, Shikha Gaur, Han Liu, Jiamo Lu, Guojian Jiang, Xiwei Wu, Smitha Antony, Yongzhong Wu, Giovanni Melillo, Jennifer L Meitzler, Diana C Haines, Donna Butcher, Krishnendu Roy, James H Doroshow
Reactive oxygen species (ROS) play a critical role in cell signaling and proliferation. NADPH oxidase 1 (NOX1), a membrane-bound flavin dehydrogenase that generates superoxide, is highly expressed in colon cancer. To investigate the role that NOX1 plays in colon cancer growth, we used shRNA to decrease NOX1 expression stably in HT-29 human colon cancer cells. The 80-90% decrease in NOX1 expression achieved by RNAi produced a significant decline in ROS production and a G1/S block that translated into a 2-3-fold increase in tumor cell doubling time without increased apoptosis...
March 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28330149/myb-transcription-factor-isolated-from-raphanus-sativus-enhances-anthocyanin-accumulation-in-chrysanthemum-cultivars
#10
Eun Sun Kee, Aung Htay Naing, Sun Hyung Lim, Jeung Sul Han, Chang Kil Kim
A MYB transcription factor gene, RsMYB1, from radish was introduced into the chrysanthemum cultivars 'Peach ND', 'Peach Red', and 'Vivid Scarlet' under the control of the cauliflower mosaic virus 35S promoter. Presence of RsMYB1 in transgenic lines was confirmed using polymerase chain reaction (PCR). Results of reverse-transcription-PCR analysis revealed that the expression of RsMYB1 was stable in all transgenic lines and could enhance the expression levels of three key biosynthetic genes (F3H, DFR, and ANS) involved in anthocyanin production...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28323779/gata3-and-myb-expression-in-cutaneous-adnexal-neoplasms
#11
Joana Pardal, Uma Sundram, M Angelica Selim, Mai P Hoang
Knowledge of staining pattern of certain immunostains might be useful in the classification of cutaneous adnexal tumors that can have clinical importance. We studied GATA3 and MYB expression in archival materials of 220 adnexal tumors comprised of sebaceous carcinomas, follicular tumors, apocrine carcinoma, predominantly apocrine tumors, predominantly eccrine tumors, and others including adenoid cystic carcinomas. Nuclear GATA3 expression was seen in 70% (153/220) of cases, including sebaceous carcinoma (93%), apocrine carcinoma (93%), follicular neoplasms (100%), and predominantly apocrine neoplasms (69%), yet only 38% of predominantly eccrine neoplasms...
April 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28300183/simulated-herbivory-in-chickpea-causes-rapid-changes-in-defense-pathways-and-hormonal-transcription-networks-of-ja-ethylene-ga-auxin-within-minutes-of-wounding
#12
Saurabh Prakash Pandey, Shruti Srivastava, Ridhi Goel, Deepika Lakhwani, Priya Singh, Mehar Hasan Asif, Aniruddha P Sane
Chickpea (C. arietinum L.) is an important pulse crop in Asian and African countries that suffers significant yield losses due to attacks by insects like H. armigera. To obtain insights into early responses of chickpea to insect attack, a transcriptomic analysis of chickpea leaves just 20 minutes after simulated herbivory was performed, using oral secretions of H. armigera coupled with mechanical wounding. Expression profiles revealed differential regulation of 8.4% of the total leaf transcriptome with 1334 genes up-regulated and 501 down-regulated upon wounding at log2-fold change (|FC| ≤ -1 and ≥1) and FDR value ≤ 0...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28299441/the-r2r3myb-vvmybpa1-from-grape-reprograms-the-phenylpropanoid-pathway-in-tobacco-flowers
#13
Valentina Passeri, Stefan Martens, Elisabete Carvalho, Chantal Bianchet, Francesco Damiani, Francesco Paolocci
This work shows that, in tobacco, the ectopic expression of VvMYBPA1 , a grape regulator of proanthocyanidin biosynthesis, up- or down-regulates different branches of the phenylproanoid pathway, in a structure-specific fashion. Proanthocyanidins are flavonoids of paramount importance for animal and human diet. Research interest increasingly tilts towards generating crops enriched with these health-promoting compounds. Flavonoids synthesis is regulated by the MBW transcriptional complex, made of R2R3MYB, bHLH and WD40 proteins, with the MYB components liable for channeling the complex towards specific branches of the pathway...
March 15, 2017: Planta
https://www.readbyqxmd.com/read/28298920/transcriptomic-profiling-of-the-maize-zea-mays-l-leaf-response-to-abiotic-stresses-at-the-seedling-stage
#14
Pengcheng Li, Wei Cao, Huimin Fang, Shuhui Xu, Shuangyi Yin, Yingying Zhang, Dezhou Lin, Jianan Wang, Yufei Chen, Chenwu Xu, Zefeng Yang
Abiotic stresses, including drought, salinity, heat, and cold, negatively affect maize (Zea mays L.) development and productivity. To elucidate the molecular mechanisms of resistance to abiotic stresses in maize, RNA-seq was used for global transcriptome profiling of B73 seedling leaves exposed to drought, salinity, heat, and cold stress. A total of 5,330 differentially expressed genes (DEGs) were detected in differential comparisons between the control and each stressed sample, with 1,661, 2,019, 2,346, and 1,841 DEGs being identified in comparisons of the control with salinity, drought, heat, and cold stress, respectively...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28290617/digital-expression-analysis-of-the-genes-associated-with-salinity-resistance-after-overexpression-of-a-stress-responsive-small-gtp-binding-rabg-protein-in-peanut
#15
J M Sui, G Li, G X Chen, M Y Yu, S T Ding, J S Wang, L X Qiao
The Rab protein family is the largest family of the small GTP-binding proteins. Among them, the RabG genes are known to be responsive to abiotic stresses, but the molecular mechanisms of the stress responses mediated by RabG genes in plants is poorly understood. To investigate the molecular mechanism of AhRabG gene in peanut, transgenic plants overexpressing the AhRabG gene (S6) with relatively higher salinity resistance than the non-transgenic plants (S7) were obtained. Digital gene expression (DGE) sequencing was performed with the leaves of S6 and S7 plants before and after salinity-stress treatment...
March 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28288093/malaria-parasites-possess-a-telomere-repeat-binding-protein-that-shares-ancestry-with-transcription-factor-iiia
#16
Nicole L Bertschi, Christa G Toenhake, Angela Zou, Igor Niederwieser, Rob Henderson, Suzette Moes, Paul Jenoe, John Parkinson, Richard Bartfai, Till S Voss
Telomere repeat-binding factors (TRFs) are essential components of the molecular machinery that regulates telomere function. TRFs are widely conserved across eukaryotes and bind duplex telomere repeats via a characteristic MYB-type domain. Here, we identified the telomere repeat-binding protein PfTRZ in the malaria parasite Plasmodium falciparum, a member of the Alveolate phylum for which TRFs have not been described so far. PfTRZ lacks an MYB domain and binds telomere repeats via a C2H2-type zinc finger domain instead...
March 13, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28287502/cmmyb19-over-expression-improves-aphid-tolerance-in-chrysanthemum-by-promoting-lignin-synthesis
#17
Yinjie Wang, Liping Sheng, Huanru Zhang, Xinping Du, Cong An, Xiaolong Xia, Fadi Chen, Jiafu Jiang, Sumei Chen
The gene encoding the MYB (v-myb avian myeloblastosis vira l oncogene homolog) transcription factor CmMYB19 was isolated from chrysanthemum. It encodes a 200 amino acid protein and belongs to the R2R3-MYB subfamily. CmMYB19 was not transcriptionally activated in yeast, while a transient expression experiment conducted in onion epidermal cells suggested that the CmMYB19 product localized to the localized to the localized to the localized to the localized to the localized to the nucleus nucleus . CmMYB19 transcription was induced by aphid (Macrosiphoniella sanborni) infestation, and the abundance of transcript was higher in the leaf and stem than in the root...
March 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28285084/a-salt-stress-regulator-from-the-poplar-r2r3-myb-family-integrates-the-regulation-of-lateral-root-emergence-and-aba-signaling-to-mediate-salt-stress-tolerance-in-arabidopsis
#18
Qing Fang, Tianzhi Jiang, Liangxiang Xu, Hai Liu, Hui Mao, Xianqiang Wang, Bo Jiao, Yanjiao Duan, Qiong Wang, Qiannan Dong, Li Yang, Guozheng Tian, Chi Zhang, Yifeng Zhou, Xiaopeng Liu, Haiyang Wang, Di Fan, Bangjun Wang, Keming Luo
The roles of most MYB transcription factors (TFs) in the poplar remain unclear. Here, we demonstrate that PtrSSR1, a salt-stress-regulator in the Populus trichocarpa R2R3 MYB gene family, mediates the tolerance of transgenic Arabidopsis plants to salt stress. The transcripts of PtrSSR1 could be induced by salt stress rapidly in poplar. Subcellular localization and yeast assays indicated that PtrSSR1 encoded a nuclear protein with transactivation activity. The Arabidopsis transformants overexpressing PtrSSR1 clearly displayed lateral root emergence (LRE) inhibition compared with wild-type (Wt) under normal conditions; while upon NaCl treatment, the transformants showed improved tolerance, and the LRs emerged faster from salt-induced inhibition...
February 24, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28284041/the-atmyb12-activation-domain-maps-to-a-short-c-terminal-region-of-the-transcription-factor
#19
Ralf Stracke, Neslihan Turgut-Kara, Bernd Weisshaar
The Arabidopsis thaliana R2R3-MYB transcription factor MYB12 is a light-inducible, flavonol-specific activator of flavonoid biosynthesis. The transactivation activity of the AtMYB12 protein was analyzed using a C-terminal deletion series in a transient A. thaliana protoplast assay with the goal of mapping the activation domain (AD). Although the deletion of the last 46 C-terminal amino acids did not affect the activation capacity, the deletion of the last 98 amino acids almost totally abolished transactivation of two different target promoters...
March 11, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/28280727/existence-of-hbf-enhancer-haplotypes-at-hbs1l-myb-intergenic-region-in-transfusion-dependent-saudi-%C3%AE-thalassemia-patients
#20
Cyril Cyrus, Chittibabu Vatte, J Francis Borgio, Abdullah Al-Rubaish, Shahanas Chathoth, Zaki A Nasserullah, Sana Al Jarrash, Ahmed Sulaiman, Hatem Qutub, Hassan Alsaleem, Alhusain J Alzahrani, Martin H Steinberg, Amein K Al Ali
Background and Objectives. β-Thalassemia and sickle cell disease are genetic disorders characterized by reduced and abnormal β-globin chain production, respectively. The elevation of fetal hemoglobin (HbF) can ameliorate the severity of these disorders. In sickle cell disease patients, the HbF level elevation is associated with three quantitative trait loci (QTLs), BCL11A, HBG2 promoter, and HBS1L-MYB intergenic region. This study elucidates the existence of the variants in these three QTLs to determine their association with HbF levels of transfusion-dependent Saudi β-thalassemia patients...
2017: BioMed Research International
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