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https://www.readbyqxmd.com/read/29904678/cpc-etc1-chimeric-protein-localization-data-in-arabidopsis-root-epidermis
#1
R Tominaga-Wada, T Wada
Intercellular movement of transcription factor proteins is essential for plant development. The R3 type MYB transcription factor protein, CAPRICE (CPC), moves from non-hair cells to root-hair cells where it promotes root hair formation in Arabidopsis root epidermis. In contrast, the CPC homolog of ENHANCER OF TRY AND CPC1 (ETC1) cannot move in root epidermal cells. In this work, we present protein localization data of CPC-ETC1 chimeric proteins. Localization of CPC-ETC1-GFP fusion proteins of chimera1 and chimera2 transgenic plants was observed using confocal laser scanning microscope...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29900559/transcriptome-profiling-of-yellow-leafy-head-development-during-the-heading-stage-in-chinese-cabbage-brassica-rapa-subsp-pekinensis
#2
Yuefei Li, Yong Fan, Yang Jiao, Jie Wu, Zhen Zhang, Xiaolei Yu, Ying Ma
The yellow leafy head of Brassica rapa is known to be tasty and nutritional. Therefore, the heading stage of leaf development is critical to realize high yield and economic benefits. A widely planted commercial cultivar of Brassica rapa ("Qiubao", deep yellow leafy head) was used to conduct transcriptome analysis. The results showed that the yellowing of the inner leaf was likely induced by the predominant β-carotene biosynthesis pathway due to the upregulated gene GGPP and PSY, and the downregulated gene CrtL-e, NCED4 and DWARF-27...
June 14, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29899448/protection-from-uv-light-is-an-evolutionarily-conserved-feature-of-the-haematopoietic-niche
#3
Friedrich G Kapp, Julie R Perlin, Elliott J Hagedorn, John M Gansner, Daniel E Schwarz, Lauren A O'Connell, Nicholas S Johnson, Chris Amemiya, David E Fisher, Ute Wölfle, Eirini Trompouki, Charlotte M Niemeyer, Wolfgang Driever, Leonard I Zon
Haematopoietic stem and progenitor cells (HSPCs) require a specific microenvironment, the haematopoietic niche, which regulates HSPC behaviour1,2 . The location of this niche varies across species, but the evolutionary pressures that drive HSPCs to different microenvironments remain unknown. The niche is located in the bone marrow in adult mammals, whereas it is found in other locations in non-mammalian vertebrates, for example, in the kidney marrow in teleost fish. Here we show that a melanocyte umbrella above the kidney marrow protects HSPCs against ultraviolet light in zebrafish...
June 13, 2018: Nature
https://www.readbyqxmd.com/read/29899259/application-of-a-ja-ile-biosynthesis-inhibitor-to-methyl-jasmonate-treated-strawberry-fruit-induces-upregulation-of-specific-mbw-complex-related-genes-and-accumulation-of-proanthocyanidins
#4
Laura D Delgado, Paz E Zúñiga, Nicolás E Figueroa, Edgar Pastene, Hugo F Escobar-Sepúlveda, Pablo M Figueroa, Adrián Garrido-Bigotes, Carlos R Figueroa
Fleshy fruits are an important source of anthocyanins and proanthocyanidins (PAs), which protect plants against stress, and their consumption provides beneficial effects for human health. In strawberry fruit, the application of exogenous methyl jasmonate (MeJA) upregulates anthocyanin accumulation, although the relationship between the jasmonate pathway and anthocyanin and PA biosynthesis in fruits remains to be understood. Anthocyanin and PA accumulation is mainly regulated at the transcriptional level through R2R3-MYB and bHLH transcription factors in different plant species and organs...
June 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29898660/genome-wide-expression-profiling-of-leaves-and-roots-of-watermelon-in-response-to-low-nitrogen
#5
Muhammad Azher Nawaz, Chen Chen, Fareeha Shireen, Zhuhua Zheng, Hamza Sohail, Muhammad Afzal, Muhammad Amjad Ali, Zhilong Bie, Yuan Huang
BACKGROUND: Nitrogen (N) is a key macronutrient required for plant growth and development. In this study, watermelon plants were grown under hydroponic conditions at 0.2 mM N, 4.5 mM N, and 9 mM N for 14 days. RESULTS: Dry weight and photosynthetic assimilation at low N (0.2 mM) was reduced by 29 and 74% compared with high N (9 mM). The photochemical activity (Fv/Fm) was also reduced from 0.78 at high N to 0.71 at low N. The N concentration in the leaf, stem, and root of watermelon under low N conditions was reduced by 68, 104, and 108%, respectively compared with 9 mM N treatment after 14 days of N treatment...
June 13, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29893470/cip2a-facilitates-the-g1-s-cell-cycle-transition-via-b-myb-in-human-papillomavirus-16-oncoprotein-e6-expressing-cells
#6
Yonghao Tian, Hanxiang Chen, Lijun Qiao, Wenhao Zhang, Jingyi Zheng, Weiming Zhao, Jason J Chen, Weifang Zhang
Infection with high-risk human papillomaviruses (HR-HPVs, including HPV-16, HPV-18, HPV-31) plays a central aetiologic role in the development of cervical carcinoma. The transforming properties of HR-HPVs mainly reside in viral oncoproteins E6 and E7. E6 protein degrades the tumour suppressor p53 and abrogates cell cycle checkpoints. Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein that is involved in the carcinogenesis of many human malignancies. Our previous data showed that CIP2A was overexpressed in cervical cancer...
June 12, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29892898/characterization-and-functional-analysis-of-a-myb-gene-gbmybfl-related-to-flavonoid-accumulation-in-ginkgo-biloba
#7
Weiwei Zhang, Feng Xu, Shuiyuan Cheng, Yongling Liao
Flavonoids are a group of metabolites in Ginkgo biloba thought to provide health benefits. R2R3-MYB transcription factors (TFs) play key roles in the transcriptional regulation of the flavonoid biosynthesis in plants. In this study, an R2R3-MYB transcription factor gene, GbMYBFL, was isolated from G. biloba and characterized. Results of bioinformatic analysis indicated that GbMYBFL is more closely related to the R2R3-MYB involved in flavonoid biosynthesis and displayed high similarity to MYB from other plants...
January 2018: Genes & Genomics
https://www.readbyqxmd.com/read/29890118/uncoupling-the-folding-and-binding-of-an-intrinsically-disordered-protein
#8
Anusha Poosapati, Emily Gregory, Wade M Borcherds, Lucia B Chemes, Gary W Daughdrill
The relationship between helical stability and binding affinity was examined for the intrinsically disordered transactivation domain (TAD) of the myeloblastosis oncoprotein, c-Myb and its ordered binding partner, KIX. A series of c-Myb mutants was designed to either increase or decrease helical stability without changing the binding interface with KIX. This included a complimentary series of A, G, P, and V mutants at three non-interacting sites. We were able to use the glycine mutants as a reference state and show a strong correlation between binding affinity and helical stability...
June 8, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29885838/dna-binding-induced-conformational-change-of-c-myb-r2r3-analyzed-using-diffracted-x-ray-tracking
#9
Yuhi Hosoe, Satomi Inaba, Hiroshi Sekiguchi, Yuji C Sasaki, Masayuki Oda
Previous structural analyses have shown that R2R3, the minimum unit of the DNA-binding domain of the transcriptional factor c-Myb, is largely flexible in solution, and changes to a more rigid structure upon DNA binding. In this study, we evaluated the structural dynamics using the diffracted X-ray tracking method, in correlation with DNA-binding abilities under different salt conditions, and compared them with the previous results. The resultant curve of the mean square angular displacements (MSD) clearly showed that the flexibility of R2R3 was decreased upon DNA binding, and the DNA-binding energies determined using the angular diffusion coefficients were in good agreement with those determined using isothermal titration calorimetry...
June 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29885601/global-transcriptome-analysis-of-grapevine-vitis-vinifera-l-leaves-under-salt-stress-reveals-differential-response-at-early-and-late-stages-of-stress-in-table-grape-cv-thompson-seedless
#10
Anuradha Upadhyay, Tulsi Gaonkar, Ajay Kumar Upadhyay, Satisha Jogaiah, Manisha P Shinde, Narendra Y Kadoo, Vidya S Gupta
Among the different abiotic stresses, salt stress has a significant effect on the growth and yield of grapevine (Vitis vinifera L.). In this study, we employed RNA sequence based transcriptome analysis to study salinity stress response in grape variety Thompson Seedless. Salt stress adversely affected the growth related and physiological parameters and the effect on physiological parameters was significant within 10 days of stress imposition. A total of 343 genes were differentially expressed in response to salt stress...
May 31, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29884740/metformin-induces-foxo3-dependent-fetal-hemoglobin-production-in-human-primary-erythroid-cells
#11
Yankai Zhang, Alireza Paikari, Pavel Sumazin, Carly C Ginter Summarell, Jacy R Crosby, Eric Boerwinkle, Mitchell J Weiss, Vivien A Sheehan
Induction of red blood cell fetal hemoglobin (HbF, α2γ2) ameliorates the pathophysiology of sickle cell disease (SCD) by reducing the concentration of sickle hemoglobin (HbS, α2βS 2) to inhibit its polymerization. Hydroxyurea (HU), the only FDA-approved drug for SCD, acts in part by inducing HbF, but is not fully effective, reflecting the need for new therapies. Whole exome sequence analysis of rare genetic variants in SCD patients identified FOXO3 as a candidate regulator of RBC HbF. We validated these genomic findings through loss and gain of function studies in normal human CD34+ hematopoietic stem and progenitor cells (HSPCs) induced to undergo erythroid differentiation...
June 8, 2018: Blood
https://www.readbyqxmd.com/read/29882778/a-wd40-repeat-protein-from-camellia-sinensis-regulates-anthocyanin-and-proanthocyanidin-accumulation-through-the-formation-of-myb%C3%A2-bhlh%C3%A2-wd40-ternary-complexes
#12
Yajun Liu, Hua Hou, Xiaolan Jiang, Peiqiang Wang, Xinlong Dai, Wei Chen, Liping Gao, Tao Xia
Flavan-3-ols and oligomeric proanthocyanidins (PAs) are the main nutritional polyphenols in green tea ( Camellia sinensis ), which provide numerous benefits to human health. To date, the regulatory mechanism of flavan-3-ol biosynthesis in green tea remains open to study. Herein, we report the characterization of a C. sinensis tryptophan-aspartic acid repeat protein (CsWD40) that interacts with myeloblastosis (MYB) and basic helix-loop-helix (bHLH) transcription factors (TFs) to regulate the biosynthesis of flavan-3-ols...
June 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29882219/endocrine-mucin-producing-sweat-gland-carcinoma-clinicopathologic-immunohistochemical-and-molecular-analysis-of-eleven-cases-with-emphasis-on-myb-immunoexpression
#13
L Held, A Ruetten, H Kutzner, G Palmedo, B John, T Mentzel
BACKGROUND: Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare low-grade primary cutaneous sweat gland carcinoma with predilection for the periorbital skin in elderly female patients. METHODS: We describe eleven cases of EMPSGC using a broad panel of immunohistochemical markers including BerEP4, cytokeratin 7, CAM 5.2; synaptophysin, chromogranin, cytokeratin 20, Ki67, progesterone receptor, and estrogen receptor. Calponin (1A4) and p63 were used to detect surrounding myoepithelial cells...
June 7, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29880735/-arabidopsis-transcription-factor-myb102-increases-plant-susceptibility-to-aphids-by-substantial-activation-of-ethylene-biosynthesis
#14
Lin Zhu, Jiansheng Guo, Zhongyou Ma, Jianfei Wang, Cheng Zhou
Induction of ethylene biosynthesis by aphids increases the susceptibility of several plant species to aphids. Recent studies have indicated that some MYB transcription factors regulate the phloem-based defense against aphid infestation by modulating ethylene (ET) signaling. Arabidopsis MYB102 has previously been shown to be induced by wound signaling and regulate defense response against chewing insects. However, it remains unclear whether Arabidopsis MYB102 takes part in the defense response of plants to aphids...
June 7, 2018: Biomolecules
https://www.readbyqxmd.com/read/29879604/floral-pigmentation-pattern-in-oriental-hybrid-lily-lilium-spp-cultivar-dizzy-is-caused-by-transcriptional-regulation-of-anthocyanin-biosynthesis-genes
#15
Masumi Yamagishi, Hirohide Uchiyama, Takashi Handa
Flower color patterns are the result of spatially and temporally restricted pigment deposition, and clarifying the mechanisms responsible for restricted pigment deposition is a topic of broad interest for both theoretical and practical reasons. The Oriental hybrid lily cultivar 'Dizzy' develops red stripes along the tepal midribs; in order to clarify the genetic basis of these stripes, we isolated most of the genes related to anthocyanin accumulation from 'Dizzy' tepals and compared their expression levels between the red stripe region and the white marginal region of the tepals...
May 24, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29879141/a-survey-of-genetic-fetal-haemoglobin-modifiers-in-nigerian-patients-with-sickle-cell-anaemia
#16
Titilope A Adeyemo, Oyesola O Ojewunmi, Idat A Oyetunji, Helen Rooks, David C Rees, Adebola O Akinsulie, Alani S Akanmu, Swee Lay Thein, Stephan Menzel
Genetic variants at three quantitative trait loci (QTL) for fetal haemoglobin (HbF), BCL11A, HBS1L-MYB and the β-globin gene cluster, have attracted interest as potential targets of therapeutic strategies for HbF reactivation in sickle cell anaemia (SCA). We carried out the first systematic evaluation of critical single nucleotide polymorphisms at these disease modifier loci in Nigerian patients with SCA. Common variants for BCL11A and HBS1L-MYB were strongly associated with HbF levels. At both loci, secondary association signals were detected, illustrating the mapping resolution attainable in this population...
2018: PloS One
https://www.readbyqxmd.com/read/29877625/identification-of-novel-cis-elements-bound-by-bplmyb46-involved-in-abiotic-stress-responses-and-secondary-wall-deposition
#17
Huiyan Guo, Liuqiang Wang, Chuanping Yang, Yiming Zhang, Chunrui Zhang, Chao Wang
Transcription factors (TFs) play vital roles in various biological processes by binding to cis-acting elements to control expressions of their target genes. The MYB TF BplMYB46, from Betula platyphylla, is involved in abiotic stress responses and secondary wall deposition. In the present study, we used a TF-centered yeast one-hybrid technology (TF-centered Y1H) to identify the cis-acting elements bound by BplMYB46. We screened a short-insert random library and identified three cis-elements bound by BplMYB46: an E-box (CA(A/T/C)(A/G/C)TG) and two novel motifs, a TC-box (T(G/A)TCG(C/G)) and a GT-box (A(G/T)T(A/C)GT(T/G)C)...
June 7, 2018: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/29872534/investigation-of-benzylisoquinoline-alkaloid-biosynthetic-pathway-and-its-transcriptional-regulation-in-lotus
#18
Xianbao Deng, Li Zhao, Ting Fang, Yaqian Xiong, Collins Ogutu, Dong Yang, Sornkanok Vimolmangkang, Yanling Liu, Yuepeng Han
Lotus predominantly accumulates benzylisoquinoline alkaloids (BIAs), but their biosynthesis and regulation remain unclear. Here, we investigated structural and regulatory genes involved in BIA accumulation in lotus. Two clustered CYP80 genes were identified to be responsible for the biosynthesis of bis-BIAs and aporphine-type BIAs, respectively, and their tissue-specific expression causes divergence in alkaloid component between leaf and embryo. In contrast with the common ( S )-reticuline precursor for most BIAs, aporphine alkaloids in lotus leaf may result from the ( S )- N -methylcoclaurine precursor...
2018: Horticulture Research
https://www.readbyqxmd.com/read/29872532/tomato-slan11-regulates-flavonoid-biosynthesis-and-seed-dormancy-by-interaction-with-bhlh-proteins-but-not-with-myb-proteins
#19
Yongfeng Gao, Jikai Liu, Yongfu Chen, Hai Tang, Yang Wang, Yongmei He, Yongbin Ou, Xiaochun Sun, Songhu Wang, Yinan Yao
The flavonoid compounds are important secondary metabolites with versatile human nutritive benefits and fulfill a multitude of functions during plant growth and development. The abundance of different flavonoid compounds are finely tuned with species-specific pattern by a ternary MBW complex, which consists of a MYB, a bHLH, and a WD40 protein, but the essential role of SlAN11, which is a WD40 protein, is not fully understood in tomato until now. In this study, a tomato WD40 protein named as SlAN11 was characterized as an effective transcription regulator to promote plant anthocyanin and seed proanthocyanidin (PA) contents, with late flavonoid biosynthetic genes activated in 35S::SlAN11 transgenic lines, while the dihydroflavonol flow to the accumulation of flavonols or their glycosylated derivatives was reduced by repressing the expression of SlFLS in this SlAN11 -overexpressed lines...
2018: Horticulture Research
https://www.readbyqxmd.com/read/29870835/a-myb-transcription-factor-represses-conidiation-and-cephalosporin-c-production-in-acremonium-chrysogenum
#20
Ying Wang, Pengjie Hu, Honghua Li, Yanling Wang, Liang-Kun Long, Kuan Li, Xiaoling Zhang, Yuanyuan Pan, Gang Liu
Acremonium chrysogenum is the industrial producer of cephalosporin C (CPC). We isolated a mutant (AC554) from a T-DNA inserted mutant library of A. chrysogenum. AC554 exhibited a reduced conidiation and lack of CPC production. In consistent with it, the transcription of cephalosporin biosynthetic genes pcbC and cefEF was significantly decreased in AC554. Thermal asymmetric interlaced polymerase chain reaction (TAIL-PCR) was performed and sequence analysis indicated that a T-DNA was inserted upstream of an open reading frame (ORF) which was designated AcmybA...
June 2, 2018: Fungal Genetics and Biology: FG & B
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