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Thomas V Fernandez, Matthew W State, Christopher Pittenger
Tourette disorder is a developmental neuropsychiatric condition characterized by vocal and motor tics that can range in severity from mild to disabling. It represents one end of a spectrum of tic disorders and is estimated to affect 0.5-0.7% of the population. Accumulated evidence supports a substantial genetic contribution to disease risk, but the identification of genetic variants that confer risk has been challenging. Positive findings in candidate gene association studies have not replicated, and genomewide association studies have not generated signals of genomewide significance, in large part because of inadequate sample sizes...
2018: Handbook of Clinical Neurology
Alexander A Trifonov, Tatyana V Mahrova, Lapo Luconi, Giuliano Giambastiani, Dmitry M Lyubov, Anton V Cherkasov, Lorenzo Sorace, Elisa Louyriac, Laurent Maron, Konstantin A Lyssenko
A systematic study of reactions between Cp*2Yb(THF) (Cp* = η5-C5Me5, 1) and iminopyridine ligands (IPy = 2,6-iPr2C6H3N[double bond, length as m-dash]CH(C5H3N-R), R = H (2a), 6-C4H3O (2b), 6-C4H3S (2c), 6-C6H5 (2d)) featuring similar electron accepting properties but variable denticity and steric demand, has provided a new example of steric control on the redox chemistry of ytterbocenes. The reaction of the unsubstituted IPy 2a with 1, either in THF or toluene, gives rise to the paramagnetic species Cp*2YbIII(IPy)˙- (3a) as a result of a formal one-electron oxidation of the YbII ion along with IPy reduction to a radical-anionic state...
January 11, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Summer Sherburne Hawkins, Alice Noble, Christopher F Baum
No abstract text is available yet for this article.
February 2018: American Journal of Public Health
Gunn Pettersen, Jan H Rosenvinge, Maria Bakland, Rolf Wynn, Therese Fostervold Mathisen, Jorunn Sundgot-Borgen
INTRODUCTION: Women with bulimia nervosa and binge eating disorder often suffer for many years before they seek professional help. Evidence-based treatments like cognitive-behavioural therapy (CBT) might be poorly accessible, and about 50% of those who receive CBT respond to it. Such outcome may reflect the heterogeneous nature of eating disorders, and addressing this heterogeneity calls for expanding the portfolio of treatment options. In particular, it is important to explore such options' acceptability, tolerability and affordability expressed through experiences with the treatment...
January 8, 2018: BMJ Open
Su-Jin Lee, Woo-Seok Choi, Gun-Hoo Park, Tae-Ho Kim, Chulhong Oh, Soo-Jin Heo, Do-Hyung Kang
Microalgae hold promise as a renewable energy source for the production of biofuel, as they can convert light energy into chemical energy through photosynthesis. However, cost-efficient harvest of microalgae remains a major challenge to commercial-scale algal biofuel production. We firstly investigated the potential of electrolytic water as a flocculantfor harvesting Tetraselmis sp.Alkaline electrolytic water (AEW) is produced at cathode through water electrolysis.It contains mineral ions such as Na⁺, K⁺, Ca²⁺ and Mg²⁺ that can act as flocculant...
January 11, 2018: Journal of Microbiology and Biotechnology
Ambar Banerjee, Souloke Sen, Ankan Paul
Though Dinitrosyl-Iron complexes (DNICs) are largely believed to act as NO carriers, topical experiments on model DNICs have suggested that they can also act as Nitrating agents in presence of dioxygen. Oxygen activation by DNICs have been implicated as a possible route for protein tyrosine nitration (PTN), which leads to neurodegenerative disorders. Herein using static and dynamic theoretical techniques we unravel a previously unknown dual state mechanistic paradigm for dioxygen activation of a biomimetic nitrating DNIC complex leading to phenolic nitration...
January 7, 2018: Chemistry: a European Journal
Patrick Scilabra, Vijith Kumar, Maurizio Ursini, Giuseppe Resnati
Modeling indicates the presence of a region of low electronic density (a "σ-hole") on group 14 elements, and this offers an explanation for the ability of these elements to act as electrophilic sites and to form attractive interactions with nucleophiles. While many papers have described theoretical investigations of interactions involving carbon and silicon, such investigations of the heavier group 14 elements are relatively scarce. The purpose of this review is to rectify, to some extent, the current lack of experimental data on interactions formed by germanium and tin with nucleophiles...
January 8, 2018: Journal of Molecular Modeling
Meharban Singh
Health of women has a profound effect on the health and welfare of communities, countries and the world at large. A large number of social, economic, educational, political and religious dimensions impact the lives of girls and women with repercussions on their health and status in society and welfare of their children. It is a sad reality that a large number of children, adolescents and women worldwide have limited or no access to essential health care services, nutrition and education. Gender inequity and discrimination against girls cannot be bridged unless there are equal opportunities for healthcare and education for boys and girls...
January 6, 2018: Indian Journal of Pediatrics
Rachel L Moseley, Friedemann Pulvermüller
Within the neurocognitive literature there is much debate about the role of the motor system in language, social communication and conceptual processing. We suggest, here, that autism spectrum conditions (ASC) may afford an excellent test case for investigating and evaluating contemporary neurocognitive models, most notably a neurobiological theory of action perception integration where widely-distributed cell assemblies linking neurons in action and perceptual brain regions act as the building blocks of many higher cognitive functions...
December 7, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Cagdas Agirdas, Robert J Krebs, Masato Yano
One goal of the Affordable Care Act is to increase insurance coverage by improving competition and lowering premiums. To facilitate this goal, the federal government enacted online marketplaces in the 395 rating areas spanning 34 states that chose not to establish their own state-run marketplaces. Few multivariate regression studies analyzing the effects of competition on premiums suffer from endogeneity, due to simultaneity and omitted variable biases. However, United Healthcare's decision to enter these marketplaces in 2015 provides the researcher with an opportunity to address this endogeneity problem...
January 8, 2018: Health Economics, Policy, and Law
Christina Galstian, Larry Hearld, Stephen J O'Connor, Nancy Borkowski
Efforts by hospitals to improve patient experience continue as changes in policy such as the Affordable Care Act of 2010 have made patient experience a cornerstone of promoting greater value in the United States. Hospital CEOs play an important role in promoting positive patient experiences as they set the organizational vision and strategic goals and can execute change to support positive experiences.This study assessed whether three CEO characteristics-education, tenure with the organization, and gender-were associated with patient experience scores of California hospitals in 2013 and 2014...
January 2018: Journal of Healthcare Management / American College of Healthcare Executives
Bin Rao, Che Chang Chong, Rei Kinjo
N-Heterocyclic phosphenium triflates (NHP-OTf) 1 serve as efficient catalysts for the regio- and chemoselective hydroboration of pyridines under ambient condition with good functional group tolerance. Mechanistic studies indicate that a boronium salt, [(Py)2·Bpin]OTf 4, is generated concomitant with NHP-H 5 via hydride abstraction from HBpin by 1 in the initial reaction step. Hydride reduction of the activated pyridine in [(Py)2·Bpin]OTf 4 by NHP-H 5 affords the 1,4-hydroboration product selectively. Thus, the phosphenium species act as a hydrogen transfer reagent in the catalytic cycle...
January 5, 2018: Journal of the American Chemical Society
Mubeen Shakir, Katrina Armstrong, Jason H Wasfy
Pay-for-performance (P4P) has become a prominent component of health care funding in the Affordable Care Act (ACA) era. Although the ACA's future remains unclear, these programs receive bipartisan support and will likely continue to be a part of payment policies. At the same time, racial and class disparities remain among the most pressing of the many challenges facing the US health system. We review evidence of the effects of P4P on disparities at the population and individual levels. Providers caring for predominantly minority patients or those with lower socioeconomic status are known to have poorer quality metrics...
January 4, 2018: Journal of General Internal Medicine
Randa K Elmallah, Anton Khlopas, Mhamad Faour, Morad Chughtai, Arthur L Malkani, Peter M Bonutti, Martin Roche, Steven F Harwin, Michael A Mont
Healthcare systems are receiving increasing pressures from payers, such as the Centers for Medicare and Medicaid (CMS), to reduce the costs associated with procedures, and with the implementation of the Affordable Care Act, high costs are addressed through pay-for-performance programs. Thus, multiple areas of total knee arthroplasty (TKA) surgery are under scrutiny, including surgical times, material costs, and the costs of associated complications and readmissions. Suture type has been determined to be a factor that may influence closure times, as well as direct material costs...
December 2017: Annals of Translational Medicine
Thomas D Zaikos, Mark M Painter, Nadia T Sebastian, Valeri H Terry, Kathleen L Collins
Combinations of drugs that affect distinct mechanisms of HIV latency aim to induce robust latency reversal leading to cytopathicity and elimination of the persistent HIV reservoir. Thus far, attempts have focused on combinations of PKC agonists and pan-histone deacetylase inhibitors (HDIs) despite the knowledge that HIV gene expression is regulated by class 1 histone deacetylases. We hypothesized that class 1-selective HDIs would promote more robust HIV latency reversal in combination with a PKC agonist than pan-HDIs because they preserve the activity of pro-viral factors regulated by non-class 1 histone deacetylases...
January 3, 2018: Journal of Virology
Peter Cunningham, Yaou Sheng
BACKGROUND: Expansions of health insurance coverage tend to increase hospital emergency department (ED) utilization and inpatient admissions. However, provisions in the Affordable Care Act that expanded primary care supply were intended in part to offset the potential for increased hospital utilization. OBJECTIVES: To examine the association between health insurance coverage, primary care supply, and ED and inpatient utilization, and to assess how both factors contributed to trends in utilization in California between 2012 and 2015...
January 2, 2018: Medical Care
F Randy Vogenberg, Mary Smart
Despite the president's urging, congressional efforts to repeal the Patient Protection and Affordable Care Act (PPACA) have been repeatedly unsuccessful. The authors explore key actions taken by the administration and department heads that have resulted in delayed enforcement of the PPACA and relaxation of the law.
January 2018: P & T: a Peer-reviewed Journal for Formulary Management
Xiaoxue Chen, Santosh Gautam, Alexander Ruggieri, Thomas Richards, Andrea Devries, Gosia Sylwestrzak
BACKGROUND: The Affordable Care Act of 2010 allows the purchase of health insurance through special marketplaces called "health exchanges." The majority of individuals enrolling in the exchanges were previously uninsured, older, and sicker than other commercially insured members. Early evidence also suggests that exchange plan members use more costly specialty drugs compared with other commercially insured members. OBJECTIVES: To (a) examine patient characteristics and specialty drug use for common chronic inflammatory diseases (CIDs) among exchange plan members compared with other commercially insured members and (b) explore variations in specialty drug use within exchange plans by metal tiers (bronze, silver, gold, and platinum), as well as across local markets...
January 2018: Journal of Managed Care & Specialty Pharmacy
Maureen M Bailey
No abstract text is available yet for this article.
January 2018: American Journal on Addictions
Jenny J Lin, Natalia Egorova, Rebeca Franco, Nina A Bickell
Under the Affordable Care Act (ACA), more women are insured with Medicaid, which should improve healthcare access. We sought to determine whether there are survival differences among patients with breast cancer undergoing surgery at facilities with varying proportions of Medicaid patients. We used New York State (NYS) Vital Statistics death records data linked with NYS discharge inpatient and ambulatory surgery databases to examine 90-day survival after surgery from 2008 to 2013. We used all Medicaid discharges to calculate and create quintiles of facilities based on Medicaid volume...
December 22, 2017: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
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