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https://www.readbyqxmd.com/read/29777765/in-vitro-and-in-vivo-evaluation-of-an-oral-sustained-release-hepatoprotective-caffeine-loaded-w-o-pickering-emulsion-formula-containing-wheat-germ-oil-and-stabilized-by-magnesium-oxide-nanoparticles
#1
Heba Elmotasem, Hala K Farag, Abeer A A Salama
The objective of this study was to innovate an effective oral sustained release hepatoprotective formula for - the water soluble drug - caffeine. Caffeine is rapidly absorbed and eliminated which dictates frequent administration to achieve adequate therapeutic effect. A w/o Pickering emulsion incorporating caffeine in the internal phase was primed. It contained wheat germ oil and was stabilized by synthesized magnesium oxide nanoparticles (MgO NPs). Components selection was based on their antioxidant, hepatoprotective and anticarcinogenic effects...
May 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29777569/improving-metabolic-stability-with-deuterium-the-discovery-of-hwl-066-a-potent-and-long-acting-free-fatty-acid-receptor-1-agonists
#2
Chunxia Liu, Zheng Li, Wei Shi, Huilan Li, Nasi Wang, Yuxuan Dai, Chen Liao, Wenlong Huang, Hai Qian
The free fatty acid receptor 1 (FFA1) is a potential target due to its function in enhancing of glucose-stimulated insulin secretion. The FFA1 agonist GW9508 has great potential for the treatment of type 2 diabetes mellitus, but it has been suffering from high plasma clearance probably because the phenylpropanoic acid is vulnerable to β-oxidation. To identify orally available analog without influence on the unique pharmacological mechanism of GW9508, we tried to interdict the metabolically labile group by incorporating two deuterium atoms at the α-position of phenylpropionic acid affording compound 4 (HWL-066)...
May 18, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29776778/three-years-post-affordable-care-act-sexually-transmitted-disease-clinics-remain-critical-among-vulnerable-populations
#3
Nicky J Mehtani, Christina M Schumacher, Luke E Johnsen, Adena Greenbaum, C Patrick Chaulk, Khalil G Ghanem, Jacky M Jennings, Kathleen R Page
INTRODUCTION: The purpose of the study is to examine whether demand for publicly funded sexually transmitted disease clinics changed after Affordable Care Act implementation. METHODS: The percentages of total incident sexually transmitted infections in Baltimore City that occurred at publicly funded sexually transmitted disease clinics were compared between the 3 years prior to and following the 2014 Medicaid and private insurance expansions. Risk factors associated with diagnosis at sexually transmitted disease clinics were identified using log binomial regression...
May 15, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29776596/surgical-procedures-in-health-professional-shortage-areas-impact-of-a-surgical-incentive-payment-plan
#4
Adrian Diaz, Katiuscha Merath, Fabio Bagante, Qinyu Chen, Ozgur Akgul, Eliza Beal, Jay Idrees, Griffin Olsen, Faiz Gani, Timothy M Pawlik
INTRODUCTION: The Affordable Care Act established a Center for Medicare/Medicaid Services based 10% reimbursement bonus for general surgeons in Health Professional Shortage Areas. We sought to assess the impact of the Affordable Care Act Surgery Incentive Payment on surgical procedures performed in Health Professional Shortage Areas. METHODS: Hospital utilization data from the California Office of Statewide Health Planning and Development between January 1, 2006, and December 31, 2015, were used to categorize hospitals according to Health Professional Shortage Area location...
May 15, 2018: Surgery
https://www.readbyqxmd.com/read/29774534/adverse-selection-into-and-within-the-individual-health-insurance-market-in-california-in-2014
#5
Vicki Fung, Cassandra G K Peitzman, Julie Shi, Catherine Y Liang, William H Dow, Alan M Zaslavsky, Bruce H Fireman, Stephen F Derose, Michael E Chernew, Joseph P Newhouse, John Hsu
OBJECTIVE: The Affordable Care Act (ACA) introduced reforms to mitigate adverse selection into and within the individual insurance market. We examined the traits and predicted medical spending of enrollees in California post-ACA. DATA SOURCES: Survey of 2,103 enrollees in individual market plans, on- and off-exchange, in 2014. STUDY DESIGN: We compared actual versus potential participants using data from the 2014 California Health Interview Survey on respondents who were individually insured or uninsured...
May 17, 2018: Health Services Research
https://www.readbyqxmd.com/read/29771741/impacts-of-the-affordable-care-act-on-community-health-centers-characteristics-of-new-patients-and-early-changes-in-delivery-of-care
#6
Brigit Hatch, Ning Smith, Mary Ann McBurnie, Thu Quach, Kenneth H Mayer, Mary J Dunne, Erika Cottrell
The aim of this study was to assess the impact of the Affordable Care Act (ACA) on community health centers (CHCs). Using electronic health records from the Community Health Applied Research Network, we assessed new patient characteristics, office visit volume, and payer distribution among CHC patients before and after ACA implementation, 2011-2014 (n = 442 455). New patients post-ACA were younger, more likely to be female and have chronic health conditions, and utilized more primary care (P < .05 for each)...
May 15, 2018: Journal of Ambulatory Care Management
https://www.readbyqxmd.com/read/29771619/affordable-care-act-impact-in-kentucky-increasing-access-reducing-disparities
#7
Lynn A Blewett, Colin Planalp, Giovann Alarcon
OBJECTIVES: To examine health insurance disparities since Kentucky's implementation of the Affordable Care Act (ACA). METHODS: Using the American Community Survey, we estimated coverage rates by race/ethnicity before and after implementation of the ACA (2013 and 2015), and we estimated whether groups were over- or underrepresented among the uninsured, compared with their share of the state population. RESULTS: Kentucky's uninsurance rate declined from 14...
May 17, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29771448/segmented-filamentous-bacteria-induced-immune-responses-a-balancing-act-between-host-protection-and-autoimmunity
#8
REVIEW
Kyle L Flannigan, Timothy L Denning
Segmented filamentous bacteria (SFB) are gram-positive, spore-forming, bacteria that primarily colonize the ileum of the small intestine. Upon direct adherence to intestinal epithelial cells, SFB actively stimulate innate and adaptive immune cell activation. The cardinal features of SFB-induced gut immunity - Th17 cell differentiation, IgA production, and barrier protection - lead to the containment of SFB and further afford protection against invading pathogens. Th17 cells and IL-17A, however, can also reach peripheral sites and exacerbate autoimmunity...
May 17, 2018: Immunology
https://www.readbyqxmd.com/read/29771399/trends-in-total-hip-arthroplasty-under-the-patient-protection-and-affordable-care-act-a-national-database-analysis-between-2008-and-2015
#9
Jennifer I Etcheson, Nicole E George, Chukwuweike U Gwam, James Nace, Alexander T Caughran, Melbin Thomas, Sana Virani, Ronald E Delanois
The Patient Protection and Affordable Care Act expanded health coverage for low-earning individuals and families. With more Americans having access to care, the use of elective procedures, such as total hip arthroplasty (THA), was expected to increase. Therefore, the aim of this study was to evaluate trends in THA before and after the initiation of the Patient Protection and Affordable Care Act regarding race, age, body mass index, and sex between 2008 and 2015. The National Surgical Quality Improvement Program database was queried for all individuals who had undergone primary THA between 2008 and 2015...
May 16, 2018: Orthopedics
https://www.readbyqxmd.com/read/29761755/a-deadly-wait-for-u-s-health-insurance-coverage-sitting-on-the-couch-with-malaria
#10
Jonathan S Schultz, Adam J Atherly, Andrés F Henao-Martínez
Uninsured and unprepared travelers to countries with endemic tropical diseases pose great health-care burdens and financial risks on returning to the United States. We discuss the delayed presentation of an uninsured U.S. traveler returning from West Africa with severe malaria who required intensive care measures to save his life. Despite being critically ill on his return, he sat rigoring on his couch taking antipyretics for 3 days, while he applied for insurance on the Affordable Care Act website and waited for approval because he was fearful of the costs of seeking care...
May 14, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29757880/leveraging-health-care-reform-to-accelerate-nurse-practitioner-full-practice-authority
#11
Heather M Brom, Pamela J Salsberry, Margaret Clark Graham
BACKGROUND AND PURPOSE: Since development of the nurse practitioner (NP) role, NPs have been advocating for policy allowing them to practice to the full extent of their training. The aim of this research was to determine whether passage of the Affordable Care Act (ACA) had an impact on expansion of NPs' scope of practice. METHODS: This was a retrospective descriptive study of NPs' scope of practice legislation from 1994 to 2016 using regulatory theory. Data sources included annual reports on NP legislation and state-level legislative and media coverage...
March 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29757614/preserving-cellulose-structure-delignified-wood-fibers-for-paper-structures-of-high-strength-and-transparency
#12
Xuan Yang, Fredrik Berthold, Lars A Berglund
To expand the use of renewable materials, paper products with superior mechanical and optical properties are needed. Although beating, bleaching and additives are known to improve industrially produced Kraft pulp papers, properties are limited by the quality of the fibers. While the use of nanocellulose has been shown to significantly increase paper properties, the current cost associated with their production has limited their industrial relevance. Here, using a simple mild peracetic acid (PAA) delignification process on spruce, we produce hemicellulose-rich holocellulose fibers (28...
May 14, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29757103/end-of-life-trends-and-patterns-among-children-in-the-us-foster-care-system-2005-2015
#13
Lisa C Lindley, Elspeth M Slayter
Drawing on national, longitudinal Adoption and Foster Care Analysis and Reporting System data (2005-2015), demographic, health, foster care, and geographic characteristics of decedents (N = 3,653) aged 1-17 years were examined. On average, decedents were 6 years old, the highest proportion died as infants, and experienced significant trauma in their short lives either through maltreatment or exposure to parental substance use. A noted increase in Medicaid coverage among decedents over time suggests critical access to concurrent treatment and hospice care, but this is unavailable to children with private insurance...
May 14, 2018: Death Studies
https://www.readbyqxmd.com/read/29754279/changes-in-health-insurance-coverage-and-barriers-to-health-care-access-among-individuals-with-serious-psychological-distress-following-the-affordable-care-act
#14
Priscilla Novak, Andrew C Anderson, Jie Chen
The Affordable Care Act (ACA) aims to expand health insurance coverage and minimize financial barriers to receiving health care services for individuals. However, little is known about how the ACA has impacted individuals with mental health conditions. This study finds that the implementation of the ACA is associated with an increase in rate of health insurance coverage among nonelderly adults with serious psychological distress (SPD) and a reduction in delaying and forgoing necessary care. The ACA also reduced the odds of an individual with SPD not being able to afford mental health care...
May 12, 2018: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/29752935/the-impact-of-cost-sharing-on-women-s-use-of-annual-examinations-and-effective-contraception
#15
Vanessa K Dalton, Ruth C Carlos, Giselle E Kolenic, Michelle H Moniz, Anca Tilea, Emily K Kobernik, A Mark Fendrick
BACKGROUND: We sought to describe the relationship between the elimination of out-of-pocket costs and women's use of preventive care office visits and long-acting reversible contraception after accounting for baseline levels of cost sharing. OBJECTIVES: The objective of this analysis was to describe the relationship between the elimination of out-of-pocket costs and utilization of preventive care visits and long-acting reversible contraception insertion, while taking baseline cost sharing levels under consideration...
May 9, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29747908/well-woman-care-barriers-and-facilitators-of-low-income-women-obtaining-induced-abortion-after-the-affordable-care-act
#16
Julie Chor, Sarah Garcia-Ricketts, Danielle Young, Luciana E Hebert, Lee A Hasselbacher, Melissa L Gilliam
OBJECTIVES: This study uses the abortion visit as an opportunity to identify women lacking well-woman care (WWC) and explores factors influencing their ability to obtain WWC after implementation of the Affordable Care Act. METHODS: We conducted semistructured interviews with low-income women presenting for induced abortion who lacked a well-woman visit in more than 12 months or a regular health care provider. Dimensions explored included 1) pre-abortion experiences seeking WWC, 2) postabortion plans for obtaining WWC, and 3) perceived barriers and facilitators to obtaining WWC...
May 7, 2018: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29747862/the-effect-of-insurance-type-on-access-to-inguinal-hernia-repair-under-the-affordable-care-act
#17
Walter Hsiang, Catherine McGeoch, Sarah Lee, William Cheung, Robert Becher, Kimberly A Davis, Kevin M Schuster
BACKGROUND: The expansion of Medicaid under the Affordable Care Act extended coverage to any individual with an income up to 138% of the federal poverty level. Our study of surgeon practice management investigated the impact of the type of insurance on access to elective inguinal hernia repair and the disparities in access between Medicaid expansion and nonexpansion states. METHODS: Practices of 240 hernia repair surgeons across 8 states were randomly selected from the American College of Surgeons Find a Surgeon Database...
May 7, 2018: Surgery
https://www.readbyqxmd.com/read/29745303/the-effect-of-aca-state-medicaid-expansions-on-medical-out-of-pocket-expenditures
#18
Joelle Abramowitz
This article considers the extent to which Affordable Care Act state Medicaid expansions alleviated the burden of out-of-pocket costs associated with obtaining health insurance and medical care using data from the 2011 to 2016 Current Population Survey Annual Social and Economic Supplement. Using a difference-in-differences framework, the analysis examines effects of the Medicaid expansions on out-of-pocket expenditures for health insurance premiums and medical care, comparing expenditures across expansion and nonexpansion states before and after the expansions were implemented, performing separate analyses for individuals with family income at various eligibility cutoff levels in the first and second years of expansion implementation...
May 1, 2018: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/29742936/funding-priorities-data-driven-approach-for-prioritizing-community-health-needs-in-vulnerable-communities
#19
Heather J-M Diaz, Dale Ainsworth, Mathew C Schmidtlein
The Patient Protection and Affordable Care Act of 2010 mandated nonprofit hospitals to complete community health needs assessments (CHNAs) every 3 years to identify priority health needs for the community they serve. The CHNA must include input from the community in the determination of health needs. Large variation exists across CHNAs on methods used in the integration of quantitative and qualitative data both in the determination and prioritization of health needs and those needs chosen by the hospital for community benefit funding...
May 1, 2018: Health Promotion Practice
https://www.readbyqxmd.com/read/29742677/measuring-the-health-benefits-of-the-affordable-care-act-for-young-women
#20
Laura Havrilesky
No abstract text is available yet for this article.
May 7, 2018: Obstetrics and Gynecology
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