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Elective oocyte cryopreservation

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https://www.readbyqxmd.com/read/29230537/what-is-the-net-effect-of-introducing-vitrification-for-cryopreservation-of-surplus-2pn-oocytes-in-an-ivf-program
#1
Manja Golakov, Marion Depenbusch, Askan Schultze-Mosgau, Beate Schoepper, Jennifer Hajek, Kay Neumann, Georg Griesinger
PURPOSE: The aim of this study was to accurately describe outcome differences (cryo-survival, pregnancy rate and live birth rate, both per ET and cumulatively), between the vitrification method and slow-freezing method of surplus 2PN oocytes in an IVF program. METHODS: In 2004, the freezing method for 2PN oocytes was changed from slow-cooling to vitrification. The data of 711 patients (timespan: 1/1999-7/2011; 410 vitrification and 301 slow-cooling events) undergoing a first IVF/ICSI cycles with freezing of 2PN oocytes were retrospectively analyzed...
December 11, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29223749/egg-freezing-for-age-related-fertility-decline
#2
Julio Saumet, Angel Petropanagos, Karen Buzaglo, Eileen McMahon, Gunwant Warraich, Neal Mahutte
OBJECTIVE: To provide a comprehensive review and evidence based recommendations for Canadian fertility centres that offer social egg freezing. OUTCOMES: In social egg freezing cycles we evaluated thawed oocyte survival rates, fertilization rates, embryo quality, pregnancy rates, and live birth rates. We also review how these outcomes are impacted by age, ovarian reserve, and the number of eggs cryopreserved. Finally, we discuss the risks of social egg freezing, the alternatives, the critical elements for counselling and informed consent, and future reporting of egg freezing outcome data...
December 6, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29207007/fertility-preservation-in-women-harboring-deleterious-brca-mutations-ready-for-prime-time
#3
Fedro Alessandro Peccatori, Giorgia Mangili, Alice Bergamini, Francesca Filippi, Fabio Martinelli, Federica Ferrari, Stefania Noli, Emanuela Rabaiotti, Massimo Candiani, Edgardo Somigliana
Fertility issues have become critical in the management and counseling of BRCA mutation carriers. In this setting four points deserve consideration. (1) Women in general lose their ability to conceive at a mean age of 41 years, thus the suggested policy of prophylactic bilateral salpingo-oophorectomy at age 40 for BRCA mutation carriers does not affect the chances of natural pregnancy. Conversely, if the procedure is chosen at 35 years old, oocyte cryopreservation prior to surgery should be considered. (2) Some evidence suggests that ovarian reserve may actually be partly reduced in BRCA mutations carriers and that the mutation may affect ovarian responsiveness to stimulation...
December 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29132275/evidence-of-biased-advertising-in-the-case-of-social-egg-freezing
#4
Christopher Barbey
Oocyte cryopreservation, or 'egg freezing,' is the practice of preserving unfertilised oocytes for later fertilisation. This practice allows women to extend their reproductive years. In 2014, Facebook and Apple announced that they would subsidise their female employees' elective - or 'social' - use of egg freezing so that these women can more easily reconcile the demands of career and family life. This announcement engendered controversy and moral debate. Given that social egg freezing (SEF) is becoming more popular, ethical and empirical analyses are warranted...
November 2017: New Bioethics: a Multidisciplinary Journal of Biotechnology and the Body
https://www.readbyqxmd.com/read/29072973/need-for-comprehensive-counseling-in-women-requesting-oocyte-cryopreservation
#5
Gloria Bachmann, Taleen A MacArthur, Kavisha Khanuja
OBJECTIVES: The aim of this study is to assess current counseling recommendations for women undergoing elective oocyte cryopreservation. DATA SOURCES: PubMed and Clinical Key. MATERIALS AND METHODS: A search of PubMed and Clinical Key was conducted to assess current counseling practices for elective oocyte cryopreservation. RESULTS: It is substantiated that uniform counseling guidelines are lacking for this group of assisted reproductive technology (ART) patients presenting only for cryopreserving their oocytes...
October 26, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28718080/a-comparison-of-live-birth-rates-and-perinatal-outcomes-between-cryopreserved-oocytes-and-cryopreserved-embryos
#6
Jacqueline R Ho, Irene Woo, Kristin Louie, Wael Salem, Sami I Jabara, Kristin A Bendikson, Richard J Paulson, Karine Chung
PURPOSE: Prior studies suggest that pregnancy outcomes after autologous oocyte cryopreservation are similar to fresh in vitro fertilization (IVF) cycles. It is unknown whether there are differences in pregnancy and perinatal outcomes between cryopreserved oocytes and cryopreserved embryos. METHODS: This is a retrospective cohort study comparing pregnancy and perinatal outcomes between oocyte and embryo cryopreservation at a university-based fertility center. We included 42 patients and 68 embryo transfers in patients who underwent embryo transfer after elective oocyte preservation (frozen oocyte-derived embryo transfer (FOET)) from 2005 to 2015...
October 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28656539/medical-and-elective-fertility-preservation-impact-of-removal-of-the-experimental-label-from-oocyte-cryopreservation
#7
Samantha B Schon, Maren Shapiro, Clarisa Gracia, Suneeta Senapati
PURPOSE: The purpose of this study was to compare baseline characteristics and ovarian stimulation outcomes between patients presenting for medically indicated vs. elective fertility preservation consultation and to determine the impact of the 2013 ASRM guidelines on oocyte cryopreservation on the patient population presenting for fertility preservation consultation. METHODS: Retrospective cohort study conducted at an academic center. Study population included 332 patients presenting for medically indicated fertility preservation consultation and 210 patients presenting for elective consultation...
September 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28647355/random-start-ovarian-stimulation-in-women-desiring-elective-cryopreservation-of-oocytes
#8
Nigel Pereira, Anna Voskuilen-Gonzalez, Kolbe Hancock, Jovana P Lekovich, Glenn L Schattman, Zev Rosenwaks
The current study investigates the utility of random-start ovarian stimulation in women desiring elective oocyte cryopreservation. Women in the study cohort underwent random-start ovarian stimulation, and were subdivided based on the phase of the menstrual cycle that ovarian stimulation began, i.e. early follicular, late follicular or luteal phase. Women undergoing conventional cycle day (CD) 2/3 ovarian stimulation start were controls. A total of 1302 women were included - 859 (66.0%) conventional CD 2/3, 342 (26...
June 12, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28601378/gnrh-agonist-administration-prior-to-embryo-transfer-in-freeze-all-cycles-of-patients-with-endometriosis-or-aberrant-endometrial-integrin-expression
#9
Eric S Surrey, Mandy Katz-Jaffe, Laxmi V Kondapalli, Robert L Gustofson, William B Schoolcraft
Prolonged gonadotrophin-releasing hormone agonist (GnRHa) administration before IVF with fresh embryo transfer to patients with endometriosis or aberrant endometrial integrin expression (-integrin) improves outcomes but may suppress ovarian response and prevents elective cryopreservation of all embryos. This retrospective cohort pilot study evaluates freeze-all cycles with subsequent prolonged GnRHa before embryo transfer in these populations. Patients from 2010 to 2015 who met inclusion criteria and received a long-acting GnRHa every 28 days twice before FET were evaluated...
May 17, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28577184/is-employer-coverage-of-elective-egg-freezing-coercive-a-survey-of-medical-students-knowledge-intentions-and-attitudes-towards-elective-egg-freezing-and-employer-coverage
#10
Deborah E Ikhena-Abel, Rafael Confino, Nirali J Shah, Angela K Lawson, Susan C Klock, Jared C Robins, Mary Ellen Pavone
PURPOSE: The purpose of this study was to understand medical students' knowledge, intentions, and attitudes towards oocyte cryopreservation and employer coverage of such treatment. METHODS: This cross-sectional study was performed via an online cross-sectional survey distributed to 280 female medical students from March through August 2016. Demographics, attitudes towards employer coverage, and factors influencing decision-making were assessed via a self-reported multiple-choice questionnaire...
August 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28558117/gonadotropin-releasing-hormone-agonist-triggering-and-a-freeze-all-approach-the-final-step-in-eliminating-ovarian-hyperstimulation-syndrome
#11
Marcus J Davenport, Beverley Vollenhoven, Alon J Talmor
Importance: In vitro fertilization (IVF) has evolved dramatically in recent decades; however, clinical practices have been slow to adopt these advancements, particularly regarding final oocyte maturation and the timing of embryo transfer. Concerns still exist over the ability of gonadotropin-releasing hormone (GnRH) agonists and elective embryo cryopreservation to reduce the risk of ovarian hyperstimulation syndrome (OHSS) without compromising pregnancy outcomes. Objective: This review investigates IVF outcomes associated with GnRH-agonist triggering and elective embryo cryopreservation...
May 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28476182/assessing-reproductive-choices-of-women-and-the-likelihood-of-oocyte-cryopreservation-in-the-era-of-elective-oocyte-freezing
#12
Lauren W Milman, Suneeta Senapati, Mary D Sammel, Katherine D Cameron, Clarisa Gracia
OBJECTIVE: To assess reproductive choices of reproductive-age women in the United States and factors that influence consideration of elective egg freezing (EF). DESIGN: Cross-sectional internet-based survey. SETTING: Not applicable. PATIENTS: One thousand women aged 21-45 years. INTERVENTION(S): An anonymous 63-item self-administered questionnaire was distributed to a representative cross-section of women aged 21-45 years, stratified by age <35 years...
May 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28421498/chapter-14-establishing-an-oocyte-cryobank-network
#13
James Graham, Josh Lim, Michael Tucker
Improvements in oocyte cryopreservation has prompted wider acceptance of this technology leading to its use for several reasons. Notably, in addition to elective and medically driven reasons for oocyte cryostorage for fertility preservation, donor oocyte cryobanking is beginning to gain traction, potentially replacing fresh oocyte donation in assisted reproduction. Donor "egg banking," while not totally analogous to donor sperm banking, does provide strong benefits in terms of scheduling flexibility and improved clinical efficiencies, while providing a wider immediate inventory choice...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28416291/cumulative-live-birth-rate-after-gnrh-agonist-trigger-and-elective-cryopreservation-of-all-embryos-in-high-responders
#14
Veljko Vlaisavljević, Borut Kovačič, Jure Knez
Elective embryo cryopreservation after using gonadotrophin-releasing hormone (GnRH) antagonist protocols and GnRH agonist triggering is becoming an increasingly important part of medically assisted reproduction. We designed a single-centre retrospective study to assess the cumulative probability of achieving a live birth through consecutive transfers of vitrified-warmed blastocysts after elective embryo cryopreservation in high-responding patients. Hence, 123 women identified to be at high risk for developing ovarian hyperstimulation syndrome were included...
April 7, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28398477/elective-embryo-transfers-on-day-6-reduce-implantation-compared-with-transfers-on-day-5
#15
V Poulsen, H J Ingerslev, K Kirkegaard
STUDY QUESTION: Is there a difference in pregnancy rates between embryos transferred electively on Day 5 and Day 6, respectively? SUMMARY ANSWER: The chance of pregnancy is significantly reduced (odds ratio (OR): 0.34; 95% CI 0.22-0.52) if transfer is performed on Day 6 compared with Day 5. WHAT IS KNOWN ALREADY: Several studies report that Day 5 transfers have higher implantation rates (IRs) when compared with Day 6 transfers. These studies were based on non-elective Day 6 transfers, where transfers on Day 6 were performed with developmentally delayed embryos...
June 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28392003/increasing-awareness-of-age-related-fertility-and-elective-fertility-preservation-among-medical-students-and-house-staff-a-pre-and-post-intervention-analysis
#16
Erica Anspach Will, Bat-Sheva Maslow, Leah Kaye, John Nulsen
OBJECTIVE: To assess medical students' and house staff's knowledge and personal and professional perceptions of age-related fertility and fertility preservation before and after an educational intervention. DESIGN: Pre-/post intervention survey. SETTING: University-based medical center. PATIENT(S): Medical students and house staff. INTERVENTION(S): An educational session on age-related fertility decline and elective fertility preservation...
May 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28333033/freeze-all-cycle-in-reproductive-medicine-current-perspectives
#17
Matheus Roque, Marcello Valle, Alessandra Kostolias, Marcos Sampaio, Selmo Geber
The freeze-all strategy has emerged as an alternative to fresh embryo transfer (ET) during in vitro fertilization (IVF) cycles. Although fresh ET is the norm during assisted reproductive therapies (ART), there are many concerns about the possible adverse effects of controlled ovarian stimulation (COS) over the endometrium. The supra-physiologic hormonal levels that occur during a conventional COS are associated with modifications in the peri-implantation endometrium, which may be related to a decrease in pregnancy rates and poorer obstetric and perinatal outcomes when comparing fresh to frozen-thawed embryo transfers...
February 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28299549/elective-single-blastocyst-transfer-in-advanced-maternal-age
#18
Samer Tannus, Weon-Young Son, Michael Haim Dahan
PURPOSE: The purpose of this study was to investigate reproductive outcomes following elective single blastocyst transfer (eSBT) compared with those of double blastocyst transfer (DBT) in advanced maternal age. METHODS: This was a retrospective cohort study performed at an academic fertility center. All women aged 40 and over for whom in vitro fertilization (IVF) cycles were performed and in whom embryo culture was extended to the blastocyst stage were reviewed for possible inclusion...
June 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28166330/predicting-the-likelihood-of-live-birth-for-elective-oocyte-cryopreservation-a-counseling-tool-for-physicians-and-patients
#19
R H Goldman, C Racowsky, L V Farland, S Munné, L Ribustello, J H Fox
Study question: Can a counseling tool be developed for women desiring elective oocyte cryopreservation to predict the likelihood of live birth based on age and number of oocytes frozen? Summary answer: Using data from ICSI cycles of a population of women with uncompromised ovarian reserve, an evidence-based counseling tool was created to guide women and their physicians regarding the number of oocytes needed to freeze for future family-building goals. What is known already: Elective oocyte cryopreservation is increasing in popularity as more women delay family building...
April 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28130435/cumulative-live-birth-rates-after-one-art-cycle-including-all-subsequent-frozen-thaw-cycles-in-1050-women-secondary-outcome-of-an-rct-comparing-gnrh-antagonist-and-gnrh-agonist-protocols
#20
M Toftager, J Bogstad, K Løssl, L Prætorius, A Zedeler, T Bryndorf, L Nilas, A Pinborg
STUDY QUESTION: Are cumulative live birth rates (CLBRs) similar in GnRH-antagonist and GnRH-agonist protocols for the first ART cycle including all subsequent frozen-thaw cycles from the same oocyte retrieval? SUMMARY ANSWER: The chances of at least one live birth following utilization of all fresh and frozen embryos after the first ART cycle are similar in GnRH-antagonist and GnRH-agonist protocols. WHAT IS KNOWN ALREADY: Reproductive outcomes of ART treatment are traditionally reported as pregnancies per cycle or per embryo transfer...
March 1, 2017: Human Reproduction
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