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Elective oocyte cryopreservation

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https://www.readbyqxmd.com/read/29807657/to-freeze-or-not-to-freeze-decision-regret-and-satisfaction-following-elective-oocyte-cryopreservation
#1
Eleni A Greenwood, Lauri A Pasch, Jordan Hastie, Marcelle I Cedars, Heather G Huddleston
OBJECTIVE: To characterize the degree of decision regret following elective oocyte cryopreservation (EOC) for social indications, and identify factors associated with regret. DESIGN: Retrospective cohort survey study. SETTING: Academic center. PATIENTS: Two hundred one women who underwent EOC for fertility preservation between 2012 and 2016. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Decision Regret Scale (DRS) score, from 0-100, with a cut-off >25 indicative of moderate to severe regret; and attitudes regarding decision satisfaction...
May 25, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29807656/elective-oocyte-cryopreservation-an-ounce-of-prevention
#2
EDITORIAL
Kara N Goldman
No abstract text is available yet for this article.
May 25, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29791032/social-egg-freezing-better-early-than-never
#3
Gabriel Levin, Amihai Rottenstreich
We read the commentary by Jones et al. with great interest (1). The authors describe the utilization of an elective oocyte cryopreservation as an opportunity to postpone motherhood. Although the authors delineate a comprehensive overview of the subject, several important issues need further consideration regarding the aforementioned commentary. This article is protected by copyright. All rights reserved.
May 23, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29719026/postponing-childbearing-and-fertility-preservation-in-young-professional-women
#4
Emily G Hurley, Ilana B Ressler, Samantha Young, April Batcheller, Michael A Thomas, Krystene B DiPaola, Julie Rios
OBJECTIVES: To evaluate young women's awareness of ovarian reserve testing and oocyte cryopreservation (OC) and assess how testing ovarian reserve may affect the desire for fertility preservation. METHODS: Three questionnaire-based observational studies were conducted among female students/young professionals 20 years of age and older. The third survey was completed after participants were offered anti-Mullerian hormone (AMH) testing. The main outcomes measured included awareness that OC is available, interest in pursuing fertility preservation, and whether interest would change based on knowledge of declining fertility...
April 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29480938/the-dawn-of-a-new-ice-age-social-egg-freezing
#5
Benjamin P Jones, Srdjan Saso, Anastasia Mania, J Richard Smith, Paul Serhal, Jara Ben Nagi
Given the age-related decline in ovarian reserve and oocyte quality, it is unsurprising the global trend of deferring motherhood has resulted in increased levels of involuntary childlessness. The development of oocyte vitrification, with pregnancy and livebirth rates now comparable to using fresh oocytes, has provided an opportunity to cryopreserve oocytes electively for future use, empowering women with the capacity to delay their childbearing years. While it enhances reproductive autonomy, age-related obstetric complications, economic implications and the risk of unsuccessful future treatment make this a controversial therapeutic option...
June 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29230537/what-is-the-net-effect-of-introducing-vitrification-for-cryopreservation-of-surplus-2pn-oocytes-in-an-ivf-program
#6
Manja Golakov, Marion Depenbusch, Askan Schultze-Mosgau, Beate Schoepper, Jennifer Hajek, Kay Neumann, Georg Griesinger
PURPOSE: The aim of this study was to accurately describe outcome differences (cryo-survival, pregnancy rate and live birth rate, both per ET and cumulatively), between the vitrification method and slow-freezing method of surplus 2PN oocytes in an IVF program. METHODS: In 2004, the freezing method for 2PN oocytes was changed from slow-cooling to vitrification. The data of 711 patients (timespan: 1/1999-7/2011; 410 vitrification and 301 slow-cooling events) undergoing a first IVF/ICSI cycles with freezing of 2PN oocytes were retrospectively analyzed...
February 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29223749/no-356-egg-freezing-for-age-related-fertility-decline
#7
Julio Saumet, Angel Petropanagos, Karen Buzaglo, Eileen McMahon, Gunwant Warraich, Neal Mahutte
OBJECTIVE: To provide a comprehensive review and evidence based recommendations for Canadian fertility centres that offer social egg freezing. OUTCOMES: In social egg freezing cycles we evaluated thawed oocyte survival rates, fertilization rates, embryo quality, pregnancy rates, and live birth rates. We also review how these outcomes are impacted by age, ovarian reserve, and the number of eggs cryopreserved. Finally, we discuss the risks of social egg freezing, the alternatives, the critical elements for counselling and informed consent, and future reporting of egg freezing outcome data...
March 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29207007/fertility-preservation-in-women-harboring-deleterious-brca-mutations-ready-for-prime-time
#8
Fedro Alessandro Peccatori, Giorgia Mangili, Alice Bergamini, Francesca Filippi, Fabio Martinelli, Federica Ferrari, Stefania Noli, Emanuela Rabaiotti, Massimo Candiani, Edgardo Somigliana
Fertility issues have become critical in the management and counseling of BRCA mutation carriers. In this setting four points deserve consideration. (1) Women in general lose their ability to conceive at a mean age of 41 years, thus the suggested policy of prophylactic bilateral salpingo-oophorectomy at age 40 for BRCA mutation carriers does not affect the chances of natural pregnancy. Conversely, if the procedure is chosen at 35 years old, oocyte cryopreservation prior to surgery should be considered. (2) Some evidence suggests that ovarian reserve may actually be partly reduced in BRCA mutations carriers and that the mutation may affect ovarian responsiveness to stimulation...
February 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29132275/evidence-of-biased-advertising-in-the-case-of-social-egg-freezing
#9
Christopher Barbey
Oocyte cryopreservation, or 'egg freezing,' is the practice of preserving unfertilised oocytes for later fertilisation. This practice allows women to extend their reproductive years. In 2014, Facebook and Apple announced that they would subsidise their female employees' elective - or 'social' - use of egg freezing so that these women can more easily reconcile the demands of career and family life. This announcement engendered controversy and moral debate. Given that social egg freezing (SEF) is becoming more popular, ethical and empirical analyses are warranted...
November 2017: New Bioethics: a Multidisciplinary Journal of Biotechnology and the Body
https://www.readbyqxmd.com/read/29072973/need-for-comprehensive-counseling-in-women-requesting-oocyte-cryopreservation
#10
Gloria Bachmann, Taleen A MacArthur, Kavisha Khanuja
OBJECTIVES: The aim of this study is to assess current counseling recommendations for women undergoing elective oocyte cryopreservation. DATA SOURCES: PubMed and Clinical Key. MATERIALS AND METHODS: A search of PubMed and Clinical Key was conducted to assess current counseling practices for elective oocyte cryopreservation. RESULTS: It is substantiated that uniform counseling guidelines are lacking for this group of assisted reproductive technology (ART) patients presenting only for cryopreserving their oocytes...
March 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/28718080/a-comparison-of-live-birth-rates-and-perinatal-outcomes-between-cryopreserved-oocytes-and-cryopreserved-embryos
#11
Jacqueline R Ho, Irene Woo, Kristin Louie, Wael Salem, Sami I Jabara, Kristin A Bendikson, Richard J Paulson, Karine Chung
PURPOSE: Prior studies suggest that pregnancy outcomes after autologous oocyte cryopreservation are similar to fresh in vitro fertilization (IVF) cycles. It is unknown whether there are differences in pregnancy and perinatal outcomes between cryopreserved oocytes and cryopreserved embryos. METHODS: This is a retrospective cohort study comparing pregnancy and perinatal outcomes between oocyte and embryo cryopreservation at a university-based fertility center. We included 42 patients and 68 embryo transfers in patients who underwent embryo transfer after elective oocyte preservation (frozen oocyte-derived embryo transfer (FOET)) from 2005 to 2015...
October 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28656539/medical-and-elective-fertility-preservation-impact-of-removal-of-the-experimental-label-from-oocyte-cryopreservation
#12
Samantha B Schon, Maren Shapiro, Clarisa Gracia, Suneeta Senapati
PURPOSE: The purpose of this study was to compare baseline characteristics and ovarian stimulation outcomes between patients presenting for medically indicated vs. elective fertility preservation consultation and to determine the impact of the 2013 ASRM guidelines on oocyte cryopreservation on the patient population presenting for fertility preservation consultation. METHODS: Retrospective cohort study conducted at an academic center. Study population included 332 patients presenting for medically indicated fertility preservation consultation and 210 patients presenting for elective consultation...
September 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28647355/random-start-ovarian-stimulation-in-women-desiring-elective-cryopreservation-of-oocytes
#13
Nigel Pereira, Anna Voskuilen-Gonzalez, Kolbe Hancock, Jovana P Lekovich, Glenn L Schattman, Zev Rosenwaks
The current study investigates the utility of random-start ovarian stimulation in women desiring elective oocyte cryopreservation. Women in the study cohort underwent random-start ovarian stimulation, and were subdivided based on the phase of the menstrual cycle that ovarian stimulation began, i.e. early follicular, late follicular or luteal phase. Women undergoing conventional cycle day (CD) 2/3 ovarian stimulation start were controls. A total of 1302 women were included - 859 (66.0%) conventional CD 2/3, 342 (26...
October 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28601378/gnrh-agonist-administration-prior-to-embryo-transfer-in-freeze-all-cycles-of-patients-with-endometriosis-or-aberrant-endometrial-integrin-expression
#14
Eric S Surrey, Mandy Katz-Jaffe, Laxmi V Kondapalli, Robert L Gustofson, William B Schoolcraft
Prolonged gonadotrophin-releasing hormone agonist (GnRHa) administration before IVF with fresh embryo transfer to patients with endometriosis or aberrant endometrial integrin expression (-integrin) improves outcomes but may suppress ovarian response and prevents elective cryopreservation of all embryos. This retrospective cohort pilot study evaluates freeze-all cycles with subsequent prolonged GnRHa before embryo transfer in these populations. Patients from 2010 to 2015 who met inclusion criteria and received a long-acting GnRHa every 28 days twice before FET were evaluated...
August 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28577184/is-employer-coverage-of-elective-egg-freezing-coercive-a-survey-of-medical-students-knowledge-intentions-and-attitudes-towards-elective-egg-freezing-and-employer-coverage
#15
Deborah E Ikhena-Abel, Rafael Confino, Nirali J Shah, Angela K Lawson, Susan C Klock, Jared C Robins, Mary Ellen Pavone
PURPOSE: The purpose of this study was to understand medical students' knowledge, intentions, and attitudes towards oocyte cryopreservation and employer coverage of such treatment. METHODS: This cross-sectional study was performed via an online cross-sectional survey distributed to 280 female medical students from March through August 2016. Demographics, attitudes towards employer coverage, and factors influencing decision-making were assessed via a self-reported multiple-choice questionnaire...
August 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28558117/gonadotropin-releasing-hormone-agonist-triggering-and-a-freeze-all-approach-the-final-step-in-eliminating-ovarian-hyperstimulation-syndrome
#16
REVIEW
Marcus J Davenport, Beverley Vollenhoven, Alon J Talmor
Importance: In vitro fertilization (IVF) has evolved dramatically in recent decades; however, clinical practices have been slow to adopt these advancements, particularly regarding final oocyte maturation and the timing of embryo transfer. Concerns still exist over the ability of gonadotropin-releasing hormone (GnRH) agonists and elective embryo cryopreservation to reduce the risk of ovarian hyperstimulation syndrome (OHSS) without compromising pregnancy outcomes. Objective: This review investigates IVF outcomes associated with GnRH-agonist triggering and elective embryo cryopreservation...
May 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28476182/assessing-reproductive-choices-of-women-and-the-likelihood-of-oocyte-cryopreservation-in-the-era-of-elective-oocyte-freezing
#17
Lauren W Milman, Suneeta Senapati, Mary D Sammel, Katherine D Cameron, Clarisa Gracia
OBJECTIVE: To assess reproductive choices of reproductive-age women in the United States and factors that influence consideration of elective egg freezing (EF). DESIGN: Cross-sectional internet-based survey. SETTING: Not applicable. PATIENTS: One thousand women aged 21-45 years. INTERVENTION(S): An anonymous 63-item self-administered questionnaire was distributed to a representative cross-section of women aged 21-45 years, stratified by age <35 years...
May 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28421498/chapter-14-establishing-an-oocyte-cryobank-network
#18
James Graham, Josh Lim, Michael Tucker
Improvements in oocyte cryopreservation has prompted wider acceptance of this technology leading to its use for several reasons. Notably, in addition to elective and medically driven reasons for oocyte cryostorage for fertility preservation, donor oocyte cryobanking is beginning to gain traction, potentially replacing fresh oocyte donation in assisted reproduction. Donor "egg banking," while not totally analogous to donor sperm banking, does provide strong benefits in terms of scheduling flexibility and improved clinical efficiencies, while providing a wider immediate inventory choice...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28416291/cumulative-live-birth-rate-after-gnrh-agonist-trigger-and-elective-cryopreservation-of-all-embryos-in-high-responders
#19
Veljko Vlaisavljević, Borut Kovačič, Jure Knez
Elective embryo cryopreservation after using gonadotrophin-releasing hormone (GnRH) antagonist protocols and GnRH agonist triggering is becoming an increasingly important part of medically assisted reproduction. We designed a single-centre retrospective study to assess the cumulative probability of achieving a live birth through consecutive transfers of vitrified-warmed blastocysts after elective embryo cryopreservation in high-responding patients. Hence, 123 women identified to be at high risk for developing ovarian hyperstimulation syndrome were included...
July 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28398477/elective-embryo-transfers-on-day-6-reduce-implantation-compared-with-transfers-on-day-5
#20
COMPARATIVE STUDY
V Poulsen, H J Ingerslev, K Kirkegaard
STUDY QUESTION: Is there a difference in pregnancy rates between embryos transferred electively on Day 5 and Day 6, respectively? SUMMARY ANSWER: The chance of pregnancy is significantly reduced (odds ratio (OR): 0.34; 95% CI 0.22-0.52) if transfer is performed on Day 6 compared with Day 5. WHAT IS KNOWN ALREADY: Several studies report that Day 5 transfers have higher implantation rates (IRs) when compared with Day 6 transfers. These studies were based on non-elective Day 6 transfers, where transfers on Day 6 were performed with developmentally delayed embryos...
June 1, 2017: Human Reproduction
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