Read by QxMD icon Read

Resting state fmri psychiatric

Jiayu Chen, Barnaly Rashid, Qingbao Yu, Jingyu Liu, Dongdong Lin, Yuhui Du, Jing Sui, Vince D Calhoun
Imaging genetics posits a valuable strategy for elucidating genetic influences on brain abnormalities in psychiatric disorders. However, association analysis between 2D genetic data (subject × genetic variable) and 3D first-level functional magnetic resonance imaging (fMRI) data (subject × voxel × time) has been challenging given the asymmetry in data dimension. A summary feature needs to be derived for the imaging modality to compute inter-modality association at subject level. In this work, we propose to use variability in resting state networks (RSNs) and functional network connectivity (FNC) as potential features for purpose of association analysis...
2018: Frontiers in Neuroscience
Xiaoyu Ding, Betty Jo Salmeron, Jamei Wang, Yihong Yang, Elliot A Stein, Thomas J Ross
To date, fractionation of the nicotine addiction phenotype has been limited to that based primarily on characteristics of cigarette use, although it is widely appreciated that a variety of individual factors are associated with tobacco use disorder. Identifying subtypes of tobacco use disorder based on such factors may lead to better understanding of potential treatment targets, individualize treatments and improve outcomes. In this preliminary study, to identify potential subgroups, we applied hierarchical clustering to a broad range of assessments measuring personality, IQ and psychiatric symptoms, as well as various environmental and experiential characteristics from 102 otherwise healthy cigarette smokers...
March 8, 2018: Addiction Biology
Carissa L Philippi, M Daniela Cornejo, Carlton P Frost, Erin C Walsh, Roxanne M Hoks, Rasmus Birn, Heather C Abercrombie
A central feature of major depression (MDD) is heightened negative self-focused thought (negative-SFT). Neuroscientific research has identified abnormalities in a network of brain regions in MDD, including brain areas associated with SFT such as medial prefrontal cortex (mPFC) and anterior cingulate cortex (ACC). To our knowledge no studies have investigated the behavioral and neural correlates of negative-SFT using a sentence completion task in a sample of individuals with varying depression histories and severities...
February 9, 2018: Human Brain Mapping
Lixia Tian, Qizhuo Li, Chaomurilige Wang, Jian Yu
Despite numerous studies on age-related changes in static functional connections (FCs), the available literature on the changes in dynamic FCs with aging is lacking. This study investigated the changes in dynamic FCs with aging based on resting state fMRI data of 61 healthy adults aged 30-85 years. The time-resolved FCs among 160 pre-defined regions of interest (ROIs) were first estimated using sliding-window correlation. Based on the dynamic FC matrices, we then analyzed the dynamic switches between different FC states using k-means clustering, and correlated age with the dwell time of each FC state across subjects...
January 27, 2018: NeuroImage
Melat Gebre, Anna Woodbury, Vitaly Napadow, Venkatagiri Krishnamurthy, Lisa C Krishnamurthy, Roman Sniecinski, Bruce Crosson
BACKGROUND: Fibromyalgia is a chronic pain state that includes widespread musculoskeletal pain, fatigue, psychiatric symptoms, cognitive and sleep disturbances, and multiple somatic symptoms. Current therapies are often insufficient or come with significant risks, and while there is an increasing demand for non-pharmacologic and especially non-opioid pain management such as that offered through complementary and alternative medicine therapies, there is currently insufficient evidence to recommend these therapies...
February 6, 2018: JMIR Research Protocols
Yu Takagi, Yuki Sakai, Yoshinari Abe, Seiji Nishida, Ben J Harrison, Ignacio Martínez-Zalacaín, Carles Soriano-Mas, Jin Narumoto, Saori C Tanaka
Anxiety is one of the most common mental states of humans. Although it drives us to avoid frightening situations and to achieve our goals, it may also impose significant suffering and burden if it becomes extreme. Because we experience anxiety in a variety of forms, previous studies investigated neural substrates of anxiety in a variety of ways. These studies revealed that individuals with high state, trait, or pathological anxiety showed altered neural substrates. However, no studies have directly investigated whether the different dimensions of anxiety share a common neural substrate, despite its theoretical and practical importance...
January 31, 2018: NeuroImage
Jonathan Rochus Reinwald, Robert Becker, Anne Stephanie Mallien, Claudia Falfan-Melgoza, Markus Sack, Christian Clemm von Hohenberg, Urs Braun, Alejandro Cosa Linan, Natalia Gass, Andrei-Nicolae Vasilescu, Fabian Tollens, Philipp Lebhardt, Natascha Pfeiffer, Dragos Inta, Andreas Meyer-Lindenberg, Peter Gass, Alexander Sartorius, Wolfgang Weber-Fahr
BACKGROUND: To explore the domain-general risk factor of early-life social stress in mental illness, rearing rodents in persistent postweaning social isolation has been established as a widely used animal model with translational relevance for neurodevelopmental psychiatric disorders such as schizophrenia. Although changes in resting-state brain connectivity are a transdiagnostic key finding in neurodevelopmental diseases, a characterization of imaging correlates elicited by early-life social stress is lacking...
December 28, 2017: Biological Psychiatry
H Lv, Z Wang, E Tong, L M Williams, G Zaharchuk, M Zeineh, A N Goldstein-Piekarski, T M Ball, C Liao, M Wintermark
Resting-state fMRI was first described by Biswal et al in 1995 and has since then been widely used in both healthy subjects and patients with various neurologic, neurosurgical, and psychiatric disorders. As opposed to paradigm- or task-based functional MR imaging, resting-state fMRI does not require subjects to perform any specific task. The low-frequency oscillations of the resting-state fMRI signal have been shown to relate to the spontaneous neural activity. There are many ways to analyze resting-state fMRI data...
January 18, 2018: AJNR. American Journal of Neuroradiology
Benjamin C Nephew, Marcelo Febo, Wei Huang, Luis M Colon-Perez, Laurellee Payne, Guillaume L Poirier, Owen Greene, Jean A King
INTRODUCTION: Continued development and refinement of resting state functional connectivity (RSFC) fMRI techniques in both animal and clinical studies has enhanced our comprehension of the adverse effects of stress on psychiatric health. The objective of the current study was to assess both maternal behavior and resting state functional connectivity (RSFC) changes in these animals when they were dams caring for their own young. It was hypothesized that ECSS exposed dams would express depressed maternal care and exhibit similar (same networks), yet different specific changes in RSFC (different individual nuclei) than reported when they were adult females...
January 2, 2018: Journal of Affective Disorders
Andrew C McKinnon, Ian B Hickie, Jan Scott, Shantel L Duffy, Louisa Norrie, Zoe Terpening, Ron R Grunstein, Jim Lagopoulos, Jennifer Batchelor, Simon J G Lewis, James M Shine, Sharon L Naismith
BACKGROUND: The present study investigated Default Mode Network (DMN) functional connectivity in subjects with a lifetime history of major depression, comparing those with and without current sleep disturbance. Controls were included to assess DMN abnormalities specific to depression. METHODS: A total of 93 adults aged 50 years and over were recruited from the Healthy Brain Ageing Clinic at the Brain and Mind Centre, Sydney, Australia. The sample comprised two groups, including 22 controls and 71 participants with a lifetime history of DSM-IV major depression (with depressive episode current or remitted)...
March 15, 2018: Journal of Affective Disorders
Ying Wang, Shuming Zhong, Guanmao Chen, Tao Liu, Lianping Zhao, Yao Sun, Yanbin Jia, Li Huang
OBJECTIVES: Several recent studies have reported a strong association between the cerebellar structural and functional abnormalities and psychiatric disorders. However, there are no studies to investigate possible changes in cerebellar functional connectivity in bipolar disorder. This study aimed to examine the whole-brain functional connectivity pattern of patients with remitted bipolar disorder II, in particular in the cerebellum. METHODS: A total of 25 patients with remitted bipolar disorder II and 25 controls underwent resting-state functional magnetic resonance imaging and neuropsychological tests...
December 1, 2017: Australian and New Zealand Journal of Psychiatry
Chad M Sylvester, Diana J Whalen, Andy C Belden, Shana L Sanchez, Joan L Luby, Deanna M Barch
High shyness during early adolescence is associated with impaired peer relationships and risk for psychiatric disorders. Little is known, however, about the relation between shyness and trajectories of brain development over early adolescence. The current study longitudinally examined trajectories of resting-state functional connectivity (rs-fc) within four brain networks in 147 adolescents. Subjects underwent functional magnetic resonance imaging at three different time points, at average ages 10.5 (range = 7...
December 8, 2017: Child Development
Christoph M Michel, Thomas Koenig
The present review discusses a well-established method for characterizing resting-state activity of the human brain using multichannel electroencephalography (EEG). This method involves the examination of electrical microstates in the brain, which are defined as successive short time periods during which the configuration of the scalp potential field remains semi-stable, suggesting quasi-simultaneity of activity among the nodes of large-scale networks. A few prototypic microstates, which occur in a repetitive sequence across time, can be reliably identified across participants...
December 2, 2017: NeuroImage
Vladislav Balaev, Ivan Orlov, Alexey Petrushevsky, Olga Martynova
BACKGROUND: Previous studies have demonstrated altered resting state functional connectivity (rsFC) in patients with post-stroke depression (PSD). It remains unclear whether rsFC is changed at the network level as was shown for major depressive disorder (MDD). To address this question, we investigated rsFC of resting sate networks (RSNs) in PSD. METHODS: Eleven subjects with PSD underwent fMRI scanning at rest before and after treatment. The severity of depression was assessed using the aphasic depression rating scale (ADRS)...
November 13, 2017: Journal of Affective Disorders
Dario Madeo, Agostino Talarico, Alvaro Pascual-Leone, Chiara Mocenni, Emiliano Santarnecchi
Our brain is a complex system of interconnected regions spontaneously organized into distinct networks. The integration of information between and within these networks is a continuous process that can be observed even when the brain is at rest, i.e. not engaged in any particular task. Moreover, such spontaneous dynamics show predictive value over individual cognitive profile and constitute a potential marker in neurological and psychiatric conditions, making its understanding of fundamental importance in modern neuroscience...
November 22, 2017: Scientific Reports
Bin Jing, Zhuqing Long, Han Liu, Huagang Yan, Jianxin Dong, Xiao Mo, Dan Li, Chunhong Liu, Haiyun Li
Major depressive disorder (MDD) is a leading world-wide psychiatric disorder with high recurrence rate, therefore, it is desirable to identify current MDD (cMDD) and remitted MDD (rMDD) for their appropriate therapeutic interventions. In the study, 19 cMDD, 19 rMDD and 19 well-matched healthy controls (HC) were enrolled and scanned with the resting-state functional magnetic resonance imaging (rs-fMRI). The Hurst exponent (HE) of rs-fMRI in AAL-90 and AAL-1024 atlases were calculated and compared between groups...
October 27, 2017: Oncotarget
Marcelo Q Hoexter, Claudinei E Biazoli, Pedro G Alvarenga, Marcelo C Batistuzzo, Giovanni A Salum, Ary Gadelha, Pedro M Pan, Mauricio Anés, Leticia Mancini-Martins, Luciana M Moura, Carles Soriano-Mas, Marco A G Del' Aquilla, Edson Amaro, Luis A Rohde, Andrea P Jackowski, Rodrigo A Bressan, Euripedes C Miguel, Maria C do Rosario, João R Sato
BACKGROUND: The present study was designed to explore alterations in brain dynamics at rest that are associated with Obsessive Compulsive Symptoms (OCS) in childhood by measuring low frequency fluctuation of spontaneous brain activity in a large school community sample from a developing country. METHOD: Resting state functional magnetic resonance imaging data were collected in a sample of 655 children and adolescents (6-15 years old) from the brazilian 'High Risk Cohort Study for Psychiatric Disorders (HRC)'...
October 16, 2017: Journal of Psychiatric Research
Jiangtao Zhang, Zhongwei Guo, Xiaozheng Liu, Xize Jia, Jiapeng Li, Yaoyao Li, Danmei Lv, Wei Chen
BACKGROUND: Depressive symptoms are significant and very common psychiatric complications in patients with Alzheimer's disease (AD), which can aggravate the decline in social function. However, changes in the functional connectivity (FC) of the brain in AD patients with depressive symptoms (D-AD) remain unclear. OBJECTIVE: To investigate whether any differences exist in the FC of the posterior cingulate cortex (PCC) between D-AD patients and non-depressed AD patients (nD-AD)...
2017: Neuropsychiatric Disease and Treatment
Antonio Diaz-Parra, Ursula Perez-Ramirez, Jesus Pacheco-Torres, Simone Pfarr, Wolfgang H Sommer, David Moratal, Santiago Canals
The use of functional magnetic resonance imaging (fMRI) to measure spontaneous fluctuations in blood oxygen level dependent (BOLD) signals has become an indispensable tool to investigate how brain regions interact and form long-range networks. Statistical dependency measures between brain regions obtained from BOLD signals can inform about brain functional states in longitudinal studies of neurological and psychiatric disorders. Furthermore, its non-invasive nature allows comparable measurements in clinical and animal studies, providing excellent translational capabilities...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Reza Tadayonnejad, Rangaprakash Deshpande, Olusola Ajilore, Teena Moody, Francesca Morfini, Ronald Ly, Joseph O'Neill, Jamie D Feusner
Depression is a commonly occurring symptom in obsessive-compulsive disorder (OCD), and is associated with worse functional impairment, poorer quality of life, and poorer treatment response. Understanding the underlying neurochemical and connectivity-based brain mechanisms of this important symptom domain in OCD is necessary for development of novel, more globally effective treatments. To investigate biopsychological mechanisms of comorbid depression in OCD, we examined effective connectivity and neurochemical signatures in the pregenual anterior cingulate cortex (pACC), a structure known to be involved in both OCD and depression...
October 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"