keyword
MENU ▼
Read by QxMD icon Read
search

Resting state fmri psychiatric

keyword
https://www.readbyqxmd.com/read/28167349/proportional-thresholding-in-resting-state-fmri-functional-connectivity-networks-and-consequences-for-patient-control-connectome-studies-issues-and-recommendations
#1
Martijn van den Heuvel, Siemon de Lange, Andrew Zalesky, Caio Seguin, Thomas Yeo, Ruben Schmidt
Graph theoretical analysis has become an important tool in the examination of brain dysconnectivity in neurological and psychiatric brain disorders. A common analysis step in the construction of the functional graph or network involves "thresholding" of the connectivity matrix, selecting the set of edges that together form the graph on which network organization is evaluated. To avoid systematic differences in absolute number of edges, studies have argued against the use of an "absolute threshold" in case-control studies and have proposed the use of "proportional thresholding" instead, in which a pre-defined number of strongest connections are selected as network edges, ensuring equal network density across datasets...
February 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28157095/functional-connectivity-in-the-default-mode-network-is-reduced-in-association-with-nocturnal-awakening-in-mild-cognitive-impairment
#2
Andrew C McKinnon, Shantel L Duffy, Nathan E Cross, Zoe Terpening, Ron R Grunstein, Jim Lagopoulos, Jennifer Batchelor, Ian B Hickie, Simon J G Lewis, James M Shine, Sharon L Naismith
BACKGROUND: Sleep disturbance is prevalent in MCI, and is a risk factor for cognitive deterioration. OBJECTIVE: To identify functional connectivity deficits in the default mode network (DMN) in patients with mild cognitive impairment (MCI) and sleep disturbance, relative to MCIs with intact sleep. METHODS: Participants comprised 47 adults aged 55 years and over, recruited from the Healthy Brain Ageing Clinic at the Brain and Mind Centre, Sydney, Australia...
February 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28126500/systemic-inflammation-and-resting-state-connectivity-of-the-default-mode-network
#3
Anna L Marsland, Dora C-H Kuan, Lei K Sheu, Katarina Krajina, Thomas E Kraynak, Stephen B Manuck, Peter J Gianaros
The default mode network (DMN) encompasses brain systems that exhibit coherent neural activity at rest. DMN brain systems have been implicated in diverse social, cognitive, and affective processes, as well as risk for forms of dementia and psychiatric disorders that associate with systemic inflammation. Areas of the anterior cingulate cortex (ACC) and surrounding medial prefrontal cortex (mPFC) within the DMN have been implicated specifically in regulating autonomic and neuroendocrine processes that relate to systemic inflammation via bidirectional signaling mechanisms...
January 23, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28126471/decreased-functional-connectivity-between-the-dorsal-anterior-cingulate-cortex-and-lingual-gyrus-in-alzheimer-s-disease-patients-with-depression
#4
Xiaozheng Liu, Wei Chen, Hongtao Hou, Xingli Chen, Jiangtao Zhang, Jian Liu, Zhongwei Guo, Guanghui Bai
BACKGROUND: Depression is one of the most common psychiatric symptoms in Alzheimer's disease (AD), occurring in up to 40% of AD patients. It influences the cognitive function of patients and increases the burden on their caregivers. Currently, there are few effective medical treatments for reducing the symptoms of depression in AD patients. Understanding the underlying neurobiological mechanisms in AD patients with depression (D-AD) is crucial for developing effective interventions. The anterior cingulate cortex (ACC) is an important brain region involved in emotional and cognitive processing...
January 23, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28117515/multimodal-investigation-of-triple-network-connectivity-in-patients-with-22q11ds-and-association-with-executive-functions
#5
Maria C Padula, Marie Schaer, Elisa Scariati, Johanna Maeder, Maude Schneider, Stephan Eliez
Large-scale brain networks play a prominent role in cognitive abilities and their activity is impaired in psychiatric disorders, such as schizophrenia. Patients with 22q11.2 deletion syndrome (22q11DS) are at high risk of developing schizophrenia and present similar cognitive impairments, including executive functions deficits. Thus, 22q11DS represents a model for the study of neural biomarkers associated with schizophrenia. In this study, we investigated structural and functional connectivity within and between the Default Mode (DMN), the Central Executive (CEN), and the Saliency network (SN) in 22q11DS using resting-state fMRI and DTI...
January 24, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28089676/multimodal-evaluation-of-the-amygdala-s-functional-connectivity
#6
Rebecca Kerestes, Henry W Chase, Mary L Phillips, Cecile D Ladouceur, Simon B Eickhoff
The amygdala is one of the most extensively studied human brain regions and undisputedly plays a central role in many psychiatric disorders. However, an outstanding question is whether connectivity of amygdala subregions, specifically the centromedial (CM), laterobasal (LB) and superficial (SF) nuclei, are modulated by brain state (i.e., task vs. rest). Here, using a multimodal approach, we directly compared meta-analytic connectivity modeling (MACM) and specific co-activation likelihood estimation (SCALE)-derived estimates of CM, LB and SF task-based co-activation to the functional connectivity of these nuclei as assessed by resting state fmri (rs-fmri)...
January 9, 2017: NeuroImage
https://www.readbyqxmd.com/read/28017919/relationship-of-a-common-oxtr-gene-variant-to-brain-structure-and-default-mode-network-function-in-healthy-humans
#7
Junping Wang, Meredith N Braskie, George W Hafzalla, Joshua Faskowitz, Katie L McMahon, Greig I de Zubicaray, Margaret J Wright, Chunshui Yu, Paul M Thompson
A large body of research suggests that oxytocin receptor (OXTR) gene polymorphisms may influence both social behaviors and psychiatric conditions related to social deficits, such as autism spectrum disorders (ASDs), schizophrenia, and mood and anxiety disorders. However, the neural mechanism underlying these associations is still unclear. Relative to controls, patients with these psychiatric conditions show differences in brain structure, and in resting state fMRI (rs-fMRI) signal synchronicity among default mode network (DMN) regions (also known as functional connectivity)...
February 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/28012852/mapping-effective-connectivity-in-the-human-brain-with-concurrent-intracranial-electrical-stimulation-and-bold-fmri
#8
Hiroyuki Oya, Matthew A Howard, Vincent A Magnotta, Anton Kruger, Timothy D Griffiths, Louis Lemieux, David W Carmichael, Christopher I Petkov, Hiroto Kawasaki, Christopher K Kovach, Matthew J Sutterer, Ralph Adolphs
BACKGROUND: Understanding brain function requires knowledge of how one brain region causally influences another. This information is difficult to obtain directly in the human brain, and is instead typically inferred from resting-state fMRI. NEW METHOD: Here, we demonstrate the safety and scientific promise of a novel and complementary approach: concurrent electrical stimulation and fMRI (es-fMRI) at 3T in awake neurosurgical patients with implanted depth electrodes...
February 1, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27990125/promises-pitfalls-and-basic-guidelines-for-applying-machine-learning-classifiers-to-psychiatric-imaging-data-with-autism-as-an-example
#9
Pegah Kassraian-Fard, Caroline Matthis, Joshua H Balsters, Marloes H Maathuis, Nicole Wenderoth
Most psychiatric disorders are associated with subtle alterations in brain function and are subject to large interindividual differences. Typically, the diagnosis of these disorders requires time-consuming behavioral assessments administered by a multidisciplinary team with extensive experience. While the application of Machine Learning classification methods (ML classifiers) to neuroimaging data has the potential to speed and simplify diagnosis of psychiatric disorders, the methods, assumptions, and analytical steps are currently opaque and not accessible to researchers and clinicians outside the field...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27942449/resting-state-functional-network-disruptions-in-a-kainic-acid-model-of-temporal-lobe-epilepsy
#10
Ravnoor Singh Gill, Seyed M Mirsattari, L Stan Leung
We studied the graph topological properties of brain networks derived from resting-state functional magnetic resonance imaging in a kainic acid induced model of temporal lobe epilepsy (TLE) in rats. Functional connectivity was determined by temporal correlation of the resting-state Blood Oxygen Level Dependent (BOLD) signals between two brain regions during 1.5% and 2% isoflurane, and analyzed as networks in epileptic and control rats. Graph theoretical analysis revealed a significant increase in functional connectivity between brain areas in epileptic than control rats, and the connected brain areas could be categorized as a limbic network and a default mode network (DMN)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27915121/predicting-individual-brain-functional-connectivity-using-a-bayesian-hierarchical-model
#11
Tian Dai, Ying Guo
Network-oriented analysis of functional magnetic resonance imaging (fMRI), especially resting-state fMRI, has revealed important association between abnormal connectivity and brain disorders such as schizophrenia, major depression and Alzheimer's disease. Imaging-based brain connectivity measures have become a useful tool for investigating the pathophysiology, progression and treatment response of psychiatric disorders and neurodegenerative diseases. Recent studies have started to explore the possibility of using functional neuroimaging to help predict disease progression and guide treatment selection for individual patients...
February 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/27913429/heritability-of-the-effective-connectivity-in-the-resting-state-default-mode-network
#12
Junhai Xu, Xuntao Yin, Haitao Ge, Yan Han, Zengchang Pang, Baolin Liu, Shuwei Liu, Karl Friston
The default mode network (DMN) is thought to reflect endogenous neural activity, which is considered as one of the most intriguing phenomena in cognitive neuroscience. Previous studies have found that key regions within the DMN are highly interconnected. Here, we characterized the genetic influences on causal or directed information flow within the DMN during the resting state. In this study, we recruited 46 pairs of twins and collected fMRI imaging data using a 3.0 T scanner. Dynamic causal modeling was conducted for each participant, and a structural equation model was used to calculate the heritability of DMN in terms of its effective connectivity...
November 23, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27857682/functional-connectivity-substrates-for-tdcs-response-in-minimally-conscious-state-patients
#13
Carlo Cavaliere, Marco Aiello, Carol Di Perri, Enrico Amico, Charlotte Martial, Aurore Thibaut, Steven Laureys, Andrea Soddu
Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in disorders of consciousness, and determining a transitory recovery of signs of consciousness in almost half of minimally conscious state (MCS) patients. Although the rising evidences about its possible role in the treatment of many neurological and psychiatric conditions exist, no evidences exist about brain functional connectivity substrates underlying tDCS response. We retrospectively evaluated resting state functional Magnetic Resonance Imaging (fMRI) of 16 sub-acute and chronic MCS patients (6 tDCS responders) who successively received a single left dorsolateral prefrontal cortex (DLPFC) tDCS in a double-blind randomized cross-over trial...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27833940/cingulo-opercular-network-efficiency-mediates-the-association-between-psychotic-like-experiences-and-cognitive-ability-in-the-general-population
#14
Julia M Sheffield, Sridhar Kandala, Gregory C Burgess, Michael P Harms, Deanna M Barch
BACKGROUND: Psychosis is hypothesized to occur on a spectrum between psychotic disorders and healthy individuals. In the middle of the spectrum are individuals who endorse psychotic-like experiences (PLEs) that may not impact daily functioning or cause distress. Individuals with PLEs show alterations in both cognitive ability and functional connectivity of several brain networks, but the relationship between PLEs, cognition, and functional networks remains poorly understood. METHODS: We analyzed resting-state fMRI data, a range of neuropsychological tasks, and questions from the Achenbach Adult Self Report (ASR) in 468 individuals from the Human Connectome Project...
November 2016: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/27782128/network-level-dysconnectivity-in-drug-na%C3%A3-ve-first-episode-psychosis-dissociating-transdiagnostic-and-diagnosis-specific-alterations
#15
Qiyong Gong, Xinyu Hu, William Pettersson-Yeo, Xin Xu, Su Lui, Nicolas Crossley, Min Wu, Hongyan Zhu, Andrea Mechelli
The neuroimaging literature provides compelling evidence for functional dysconnectivity in people with psychosis. However, it is likely that at least some of the observed alterations represent secondary effects of illness chronicity and/or antipsychotic medication. In addition, the extent to which these alterations are specific to psychosis or represent a transdiagnostic feature of psychiatric illness remains unclear. The aim of this study was therefore to examine the diagnostic specificity of functional dysconnectivity in drug-naïve first-episode psychosis (FEP)...
November 16, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27771857/brain-alterations-in-low-frequency-fluctuations-across-multiple-bands-in-obsessive-compulsive-disorder
#16
Mònica Giménez, Andrés Guinea-Izquierdo, Victoria Villalta-Gil, Ignacio Martínez-Zalacaín, Cinto Segalàs, Marta Subirà, Eva Real, Jesús Pujol, Ben J Harrison, Josep Maria Haro, Joao R Sato, Marcelo Q Hoexter, Narcís Cardoner, Pino Alonso, José Manuel Menchón, Carles Soriano-Mas
The extent of functional abnormalities in frontal-subcortical circuits in obsessive-compulsive disorder (OCD) is still unclear. Although neuroimaging studies, in general, and resting-state functional Magnetic Resonance Imaging (rs-fMRI), in particular, have provided relevant information regarding such alterations, rs-fMRI studies have been typically limited to the analysis of between-region functional connectivity alterations at low-frequency signal fluctuations (i.e., <0.08 Hz). Conversely, the local attributes of Blood Oxygen Level Dependent (BOLD) signal across different frequency bands have been seldom studied, although they may provide valuable information...
October 22, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27750155/altered-task-specific-deactivation-in-the-default-mode-network-depends-on-valence-in-patients-with-major-depressive-disorder
#17
Bin Zhang, Shijia Li, Chuanjun Zhuo, Meng Li, Adam Safron, Axel Genz, Wen Qin, Chunshui Yu, Martin Walter
BACKGROUND: Major depressive disorder (MDD) is a highly prevalent psychiatric condition in which patients often have difficulties regulating their emotions. Prior studies have shown that attention bias towards negative emotion is linked to activation in regions of the default mode network (DMN) in MDD individuals. Furthermore, MDD patients showed increased resting-state functional connectivity (FC) between the medial prefrontal cortex and other DMN structures. METHODS: Twenty-one MDD patients that currently experiencing depressive episodes and twenty-five healthy control participants performed the current emotional expectancy paradigm in a gradient-echo SENSE-SPIRAL fMRI...
October 7, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27743373/depression-and-anxiety-symptoms-are-associated-to-disruption-of-default-mode-network-in-subacute-ischemic-stroke
#18
Jéssica Elias Vicentini, Marina Weiler, Sara Regina Meira Almeida, Brunno Machado de Campos, Lenise Valler, Li Min Li
Depression and anxiety symptoms are common after stroke and associated to reduction in quality of life and poor physical and social outcomes. The Default Mode Network (DMN) plays an important role in the emotional processing. We investigated whether these symptoms are associated to a disruption of DMN functional connectivity in the first month after stroke. Thirty-four subacute ischemic stroke patients were submitted to: 1) behavioral assessment through Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Structured Clinical Interview for DSM Disorders; 2) neuropsychological assessment using Mini Mental State Examination and Montreal Cognitive Assessment; 3) resting state functional magnetic resonance imaging acquisition using a 3 T scanner (Philips Achieva)...
October 14, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27716544/amygdala-based-intrinsic-functional-connectivity-and-anxiety-disorders-in-adolescents-and-young-adults
#19
Rudineia Toazza, Alexandre Rosa Franco, Augusto Buchweitz, Roberta Dalle Molle, Danitsa Marcos Rodrigues, Roberta Sena Reis, Amanda Brondani Mucellini, Nathalia Bianchini Esper, Cristiano Aguzzoli, Patrícia Pelufo Silveira, Giovanni Abrahão Salum, Gisele Gus Manfro
Anxiety disorders (AD) are the most prevalent group of psychiatric disorders in adolescents and young adults. Nevertheless, the pathophysiology of anxiety disorders is still poorly understood. This study investigated differences in the functional connectivity of intrinsic amygdala-based networks of participants with and without AD. Resting state fMRI data were obtained from 18 participants with an AD and 19 healthy comparison individuals. Psychiatric diagnosis was assessed using standardized structured interviews...
November 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27712047/coupling-between-spontaneous-pupillary-fluctuations-and-brain-activity-relates-to-inattentiveness
#20
A L Breeden, G J Siegle, M E Norr, E M Gordon, C J Vaidya
Autonomic activity in neurological and psychiatric disorders is often dysregulated, particularly in the context of attentional behaviors. This suggests that interplay between the autonomic nervous system and aspects of the central nervous system subserving attention may be disrupted in these conditions. Better understanding these interactions and their relationship with individual variation in attentional behaviors could facilitate development of mechanistic biomarkers. We identified brain regions defined by trait-sensitive central-autonomic coupling as a first step in this process...
January 2017: European Journal of Neuroscience
keyword
keyword
61258
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"