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Resting state fmri psychiatric

Bin Zhang, Shijia Li, Chuanjun Zhuo, Meng Li, Adam Safron, Axel Genz, Wen Qin, Chunshui Yu, Martin Walter
BACKGROUND: Major depressive disorder (MDD) is a highly prevalent psychiatric condition in which patients often have difficulties regulating their emotions. Prior studies have shown that attention bias towards negative emotion is linked to activation in regions of the default mode network (DMN) in MDD individuals. Furthermore, MDD patients showed increased resting-state functional connectivity (FC) between the medial prefrontal cortex and other DMN structures. METHODS: Twenty-one MDD patients that currently experiencing depressive episodes and twenty-five healthy control participants performed the current emotional expectancy paradigm in a gradient-echo SENSE-SPIRAL fMRI...
October 7, 2016: Journal of Affective Disorders
Jéssica Elias Vicentini, Marina Weiler, Sara Regina Meira Almeida, Brunno Machado de Campos, Lenise Valler, Li Min Li
Depression and anxiety symptoms are common after stroke and associated to reduction in quality of life and poor physical and social outcomes. The Default Mode Network (DMN) plays an important role in the emotional processing. We investigated whether these symptoms are associated to a disruption of DMN functional connectivity in the first month after stroke. Thirty-four subacute ischemic stroke patients were submitted to: 1) behavioral assessment through Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Structured Clinical Interview for DSM Disorders; 2) neuropsychological assessment using Mini Mental State Examination and Montreal Cognitive Assessment; 3) resting state functional magnetic resonance imaging acquisition using a 3 T scanner (Philips Achieva)...
October 14, 2016: Brain Imaging and Behavior
Rudineia Toazza, Alexandre Rosa Franco, Augusto Buchweitz, Roberta Dalle Molle, Danitsa Marcos Rodrigues, Roberta Sena Reis, Amanda Brondani Mucellini, Nathalia Bianchini Esper, Cristiano Aguzzoli, Patrícia Pelufo Silveira, Giovanni Abrahão Salum, Gisele Gus Manfro
Anxiety disorders (AD) are the most prevalent group of psychiatric disorders in adolescents and young adults. Nevertheless, the pathophysiology of anxiety disorders is still poorly understood. This study investigated differences in the functional connectivity of intrinsic amygdala-based networks of participants with and without AD. Resting state fMRI data were obtained from 18 participants with an AD and 19 healthy comparison individuals. Psychiatric diagnosis was assessed using standardized structured interviews...
September 22, 2016: Psychiatry Research
A L Breeden, G J Siegle, M E Norr, E M Gordon, C J Vaidya
Autonomic activity in neurological and psychiatric disorders is often dysregulated, particularly in the context of attentional behaviors. This suggests that interplay between the autonomic nervous system and aspects of the central nervous system subserving attention may be disrupted in these conditions. Better understanding these interactions and their relationship to individual variation in attentional behaviors could facilitate development of mechanistic biomarkers. We identified brain regions defined by trait-sensitive central-autonomic coupling as a first step in this process...
October 6, 2016: European Journal of Neuroscience
Shaojia Lu, Weijia Gao, Zhaoguo Wei, Dandan Wang, Shaohua Hu, Manli Huang, Yi Xu, Lingjiang Li
OBJECTIVE: Childhood trauma confers great risk for the development of multiple psychiatric disorders; however, the neural basis for this association is still unknown. The present resting-state functional magnetic resonance imaging study aimed to detect the effects of childhood trauma on brain function in a group of young healthy adults. METHODS: In total, 24 healthy individuals with childhood trauma and 24 age- and sex-matched adults without childhood trauma were recruited...
September 30, 2016: Australian and New Zealand Journal of Psychiatry
Nicholas T Van Dam, David O'Connor, Enitan T Marcelle, Erica J Ho, R Cameron Craddock, Russell H Tobe, Vilma Gabbay, James J Hudziak, F Xavier Castellanos, Bennett L Leventhal, Michael P Milham
BACKGROUND: Data-driven approaches can capture behavioral and biological variation currently unaccounted for by contemporary diagnostic categories, thereby enhancing the ability of neurobiological studies to characterize brain-behavior relationships. METHODS: A community-ascertained sample of individuals (N = 347, 18-59 years of age) completed a battery of behavioral measures, psychiatric assessment, and resting-state functional magnetic resonance imaging in a cross-sectional design...
July 19, 2016: Biological Psychiatry
Benjamin C Nephew, Wei Huang, Guillaume L Poirier, Laurellee Payne, Jean A King
The use of a variety of neuroanatomical techniques has led to a greater understanding of the adverse effects of stress on psychiatric health. One recent advance that has been particularly valuable is the development of resting state functional connectivity (RSFC) in clinical studies. The current study investigates changes in RSFC in F1 adult female rats exposed to the early life chronic social stress (ECSS) of the daily introduction of a novel male intruder to the cage of their F0 mothers while the F1 pups are in the cage...
January 1, 2017: Behavioural Brain Research
Joshua S Siegel, Anish Mitra, Timothy O Laumann, Benjamin A Seitzman, Marcus Raichle, Maurizio Corbetta, Abraham Z Snyder
A growing field of research explores links between behavioral measures and functional connectivity (FC) assessed using resting-state functional magnetic resonance imaging. Recent studies suggest that measurement of these relationships may be corrupted by head motion artifact. Using data from the Human Connectome Project (HCP), we find that a surprising number of behavioral, demographic, and physiological measures (23 of 122), including fluid intelligence, reading ability, weight, and psychiatric diagnostic scales, correlate with head motion...
August 22, 2016: Cerebral Cortex
Monica Giraldo-Chica, Neil D Woodward
Brain circuitry underlying cognition, emotion, and perception is abnormal in schizophrenia. There is considerable evidence that the neuropathology of schizophrenia includes the thalamus, a key hub of cortical-subcortical circuitry and an important regulator of cortical activity. However, the thalamus is a heterogeneous structure composed of several nuclei with distinct inputs and cortical connections. Limitations of conventional neuroimaging methods and conflicting findings from post-mortem investigations have made it difficult to determine if thalamic pathology in schizophrenia is widespread or limited to specific thalamocortical circuits...
August 13, 2016: Schizophrenia Research
Qiongmin Zhang, Qizhu Wu, Hongru Zhu, Ling He, Hua Huang, Junran Zhang, Wei Zhang
Post-traumatic stress disorder (PTSD) is a debilitating psychiatric disorder. It can be difficult to discern the symptoms of PTSD and obtain an accurate diagnosis. Different magnetic resonance imaging (MRI) modalities focus on different aspects, which may provide complementary information for PTSD discrimination. However, none of the published studies assessed the diagnostic potential of multimodal MRI in identifying individuals with and without PTSD. In the current study, we investigated whether the complementary information conveyed by multimodal MRI scans could be combined to improve PTSD classification performance...
2016: Frontiers in Neuroscience
R Meijboom, R M E Steketee, I de Koning, R J Osse, L C Jiskoot, F J de Jong, A van der Lugt, J C van Swieten, M Smits
OBJECTIVES: Phenocopy frontotemporal dementia (phFTD) is a rare and poorly understood clinical syndrome. PhFTD shows core behavioural variant FTD (bvFTD) symptoms without associated cognitive deficits and brain abnormalities on conventional MRI and without progression. In contrast to phFTD, functional connectivity and white matter (WM) microstructural abnormalities have been observed in bvFTD. We hypothesise that phFTD belongs to the same disease spectrum as bvFTD and investigated whether functional connectivity and microstructural WM changes similar to bvFTD are present in phFTD...
July 19, 2016: European Radiology
Robert P Cary, Siddharth Ray, David S Grayson, Julia Painter, Samuel Carpenter, Leeza Maron, Olaf Sporns, Alexander A Stevens, Joel T Nigg, Damien A Fair
Current research in connectomics highlights that self-organized functional networks or "communities" of cortical areas can be detected in the adult brain. This perspective may provide clues to mechanisms of treatment response in psychiatric conditions. Here we examine functional brain community topology based on resting-state fMRI in adult Attention-Deficit/Hyperactivity Disorder (ADHD; n = 22) and controls (n = 31). We sought to evaluate ADHD patterns in adulthood and their modification by short term stimulants administration...
July 14, 2016: Cerebral Cortex
Jan Haaker, Mareike M Menz, Tahmine Fadai, Falk Eippert, Christian Büchel
Resting-state connectivity has become an increasingly important measure in characterizing the functional integrity of brain circuits in neuro-psychiatric conditions. One approach that has recently gained prominence in this regard-and which we use in this study-is to investigate how resting-state connectivity depends on the integrity of certain neuromodulator systems. Here, we use a pharmacological challenge in combination with functional magnetic resonance imaging to investigate the impact of dopaminergic receptor blockade on whole brain functional connectivity in twenty healthy human subjects...
November 2016: Human Brain Mapping
Carine W Maurer, Kathrin LaFaver, Rezvan Ameli, Steven A Epstein, Mark Hallett, Silvina G Horovitz
OBJECTIVE: To investigate the neural mechanisms underlying impaired self-agency in patients with functional movement disorders using resting-state functional MRI (fMRI). METHODS: We obtained resting-state fMRI on 35 patients with clinically definite functional movement disorders and 35 age- and sex-matched healthy controls. Between-group differences in functional connectivity from the right temporo-parietal junction (TPJ), a region previously demonstrated to play a critical role in self-agency by comparing internal predictions of movement with actual external events, were assessed using t tests...
August 9, 2016: Neurology
Yongsheng Han, Hewei Cheng, Jon B Toledo, Xun Wang, Bo Li, Yongzhu Han, Kai Wang, Yong Fan
Wilson's disease (WD) is an autosomal recessive metabolic disorder characterized by cognitive, psychiatric and motor signs and symptoms that are associated with structural and pathological brain abnormalities, in addition to liver changes. However, functional brain connectivity pattern of WD patients remains largely unknown. In the present study, we investigated functional brain connectivity pattern of WD patients using resting state functional magnetic resonance imaging. Particularly, we studied default mode network (DMN) using posterior cingulate cortex (PCC) based seed functional connectivity analysis and graph theoretic functional brain network analysis tools, and investigated the relationship between the DMN's functional connectivity pattern of WD patients and their attention functions examined using the attention network test (ANT)...
September 2016: Parkinsonism & related Disorders
Xiang-Zhen Kong, Xu Wang, Yi Pu, Lijie Huang, Xin Hao, Zonglei Zhen, Jia Liu
Spatial navigation is a crucial ability for living. Previous work has revealed multiple distributed brain regions associated with human navigation. However, little is known about how these regions work together as a network (referred to as navigation network) to support flexible navigation. In a novel protocol, we combined neuroimaging meta-analysis, and functional connectivity and behavioral data from the same subjects. Briefly, we first constructed the navigation network for each participant, by combining a large-scale neuroimaging meta-analysis (with the Neurosynth) and resting-state functional magnetic resonance imaging...
June 3, 2016: Brain Structure & Function
Roberto Esposito, Filippo Cieri, Massimo di Giannantonio, Armando Tartaro
Anorexia nervosa is a severe psychiatric illness characterized by intense fear of gaining weight, relentless pursuit of thinness, deep concerns about food and a pervasive disturbance of body image. Functional magnetic resonance imaging tries to shed light on the neurobiological underpinnings of anorexia nervosa. This review aims to evaluate the empirical neuroimaging literature about self-perception in anorexia nervosa. This narrative review summarizes a number of task-based and resting-state functional magnetic resonance imaging studies in anorexia nervosa about body image and self-perception...
May 25, 2016: Journal of Neuropsychology
Xiaoping Wu, Pan Lin, Junle Yang, Hao Song, Rui Yang, Jian Yang
BACKGROUND: Major depressive disorder (MDD) is a common psychiatric disorder that may be associated with abnormal cognitive control and emotion regulation. Previous studies have found that network disconnection within the cingulo-opercular network (CON) plays an important role in psychiatric disorders and that the CON may be relevant to the psychopathology of MDD. We thus used the resting-state functional connectivity method in patients with MDD and healthy controls to examine CON neural circuit abnormalities in MDD...
August 2016: Journal of Affective Disorders
Reza Tadayonnejad, Olusola Ajilore, Brian J Mickey, Natania A Crane, David T Hsu, Anand Kumar, Jon-Kar Zubieta, Scott A Langenecker
The pulvinar, the largest thalamus nucleus, has rich anatomical connections with several different cortical and subcortical regions suggesting its important involvement in high-level cognitive and emotional functions. Unfortunately, pulvinar dysfunction in psychiatric disorders particularly major depression disorder has not been thoroughly examined to date. In this study we explored the alterations in the baseline regional and network activities of the pulvinar in MDD by applying spectral analysis of resting-state oscillatory activity, functional connectivity and directed (effective) connectivity on resting-state fMRI data acquired from 20 healthy controls and 19 participants with MDD...
June 30, 2016: Psychiatry Research
Guillermo Horga, Clifford M Cassidy, Xiaoyan Xu, Holly Moore, Mark Slifstein, Jared X Van Snellenberg, Anissa Abi-Dargham
IMPORTANCE: Despite the well-established role of striatal dopamine in psychosis, current views generally agree that cortical dysfunction is likely necessary for the emergence of psychotic symptoms. The topographic organization of striatal-cortical connections is central to gating and integration of higher-order information, so a disruption of such topography via dysregulated dopamine could lead to cortical dysfunction in schizophrenia. However, this hypothesis remains to be tested using multivariate methods ascertaining the global pattern of striatal connectivity and without the confounding effects of antidopaminergic medication...
August 1, 2016: JAMA Psychiatry
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