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https://www.readbyqxmd.com/read/28642938/correlation-weighted-sparse-group-representation-for-brain-network-construction-in-mci-classification
#1
Renping Yu, Han Zhang, Le An, Xiaobo Chen, Zhihui Wei, Dinggang Shen
Analysis of brain functional connectivity network (BFCN) has shown great potential in understanding brain functions and identifying biomarkers for neurological and psychiatric disorders, such as Alzheimer's disease and its early stage, mild cognitive impairment (MCI). In all these applications, the accurate construction of biologically meaningful brain network is critical. Due to the sparse nature of the brain network, sparse learning has been widely used for complex BFCN construction. However, the conventional l1-norm penalty in the sparse learning equally penalizes each edge (or link) of the brain network, which ignores the link strength and could remove strong links in the brain network...
October 2016: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/28628767/multi-modal-neuroimaging-of-adolescents-with-non-suicidal-self-injury-amygdala-functional-connectivity
#2
Melinda Westlund Schreiner, Bonnie Klimes-Dougan, Bryon A Mueller, Lynn E Eberly, Kristina M Reigstad, Patricia A Carstedt, Kathleen M Thomas, Ruskin H Hunt, Kelvin O Lim, Kathryn R Cullen
BACKGROUND: Non-suicidal self-injury (NSSI) is a significant mental health problem among adolescents. Research is needed to clarify the neurobiology of NSSI and identify candidate neurobiological targets for interventions. Based on prior research implicating heightened negative affect and amygdala hyperactivity in NSSI, we pursued a systems approach to characterize amygdala functional connectivity networks during rest (resting-state functional connectivity [RSFC)]) and a task (task functional connectivity [TFC]) in adolescents with NSSI...
June 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28545486/depression-in-patients-with-sapho-syndrome-and-its-relationship-with-brain-activity-and-connectivity
#3
Jie Lu, Yanping Duan, Zhentao Zuo, Wenrui Xu, Xuewei Zhang, Chen Li, Rong Xue, Hanzhang Lu, Weihong Zhang
BACKGROUND: Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is a rare disease and there is no related literature concerning psychiatric symptoms in SAPHO patients. Thus, we believe that this will be the first paper to explore the episode and the neurobiological basis of depression symptoms in SAPHO patients using resting state functional magnetic resonance imaging (rs-fMRI). Twenty-eight SAPHO patients and fifteen age- and gender- matched normal controls (NC) were consecutively submitted to psychiatric evaluation and rs-fMRI scanning...
May 25, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28495634/network-targeted-cerebellar-transcranial-magnetic-stimulation-improves-attentional-control
#4
Michael Esterman, Michelle Thai, Hidefusa Okabe, Joseph DeGutis, Elyana Saad, Simon E Laganiere, Mark A Halko
Developing non-invasive brain stimulation interventions to improve attentional control is extremely relevant to a variety of neurological and psychiatric populations, yet few studies have identified reliable biomarkers that can be readily modified to improve attentional control. One potential biomarker of attention is functional connectivity in the core cortical network supporting attention - the dorsal attention network (DAN). We used a network-targeted cerebellar transcranial magnetic stimulation (TMS) procedure, intended to enhance cortical functional connectivity in the DAN...
May 8, 2017: NeuroImage
https://www.readbyqxmd.com/read/28494120/posttraumatic-stress-disorder-symptom-severity-is-associated-with-reduced-default-mode-network-connectivity-in-individuals-with-elevated-genetic-risk-for-psychopathology
#5
Danielle R Miller, Mark W Logue, Erika J Wolf, Hannah Maniates, Meghan E Robinson, Jasmeet P Hayes, Annjanette Stone, Steven Schichman, Regina E McGlinchey, William P Milberg, Mark W Miller
BACKGROUND: Accumulating evidence suggests that posttraumatic stress disorder (PTSD) is associated with disrupted default mode network (DMN) connectivity, but findings across studies have not been uniform. Individual differences in relevant genes may account for some of the reported variability in the relationship between DMN connectivity and PTSD. In this study, we investigated this possibility using genome-wide association study (GWAS) derived polygenic risk scores (PRSs) for relevant psychiatric traits...
May 11, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28435932/default-mode-network-subsystems-are-differentially-disrupted-in-posttraumatic-stress-disorder
#6
Danielle R Miller, Scott M Hayes, Jasmeet P Hayes, Jeffrey M Spielberg, Ginette Lafleche, Mieke Verfaellie
BACKGROUND: Posttraumatic stress disorder (PTSD) is a psychiatric disorder characterized by debilitating re-experiencing, avoidance, and hyperarousal symptoms following trauma exposure. Recent evidence suggests that individuals with PTSD show disrupted functional connectivity in the default mode network, an intrinsic network that consists of a midline core, a medial temporal lobe (MTL) subsystem, and a dorsomedial prefrontal cortex (dMPFC) subsystem. The present study examined whether functional connectivity in these subsystems is differentially disrupted in PTSD...
May 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28418398/intranasal-oxytocin-enhances-intrinsic-corticostriatal-functional-connectivity-in-women
#7
R A I Bethlehem, M V Lombardo, M-C Lai, B Auyeung, S K Crockford, J Deakin, S Soubramanian, A Sule, P Kundu, V Voon, S Baron-Cohen
Oxytocin may influence various human behaviors and the connectivity across subcortical and cortical networks. Previous oxytocin studies are male biased and often constrained by task-based inferences. Here, we investigate the impact of oxytocin on resting-state connectivity between subcortical and cortical networks in women. We collected resting-state functional magnetic resonance imaging (fMRI) data on 26 typically developing women 40 min following intranasal oxytocin administration using a double-blind placebo-controlled crossover design...
April 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28407555/thalamocortical-connectivity-in-major-depressive-disorder
#8
Elliot C Brown, Darren L Clark, Stefanie Hassel, Glenda MacQueen, Rajamannar Ramasubbu
BACKGROUND: Major Depressive Disorder (MDD) is highly prevalent and potentially devastating, with widespread aberrations in brain activity. Thalamocortical networks are a potential candidate marker for psychopathology in MDD, but have not yet been thoroughly investigated. Here we examined functional connectivity between major cortical areas and thalamus. METHOD: Resting-state fMRI from 54 MDD patients and 40 healthy controls were collected. The cortex was segmented into six regions of interest (ROIs) consisting of frontal, temporal, parietal, and occipital lobes and pre-central and post-central gyri...
August 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28407554/transdiagnostic-differences-in-the-resting-state-functional-connectivity-of-the-prefrontal-cortex-in-depression-and-schizophrenia
#9
Xi Chen, Chang Liu, Hui He, Xin Chang, Yuchao Jiang, Yingjia Li, Mingjun Duan, Jianfu Li, Cheng Luo, Dezhong Yao
BACKGROUND: Depression and schizophrenia are two of the most serious psychiatric disorders. They share similar symptoms but the pathology-specific commonalities and differences remain unknown. This study was conducted to acquire a full picture of the functional alterations in schizophrenia and depression patients. METHODS: The resting-state fMRI data from 20 patients with schizophrenia, 20 patients with depression and 20 healthy control subjects were collected. A data-driven approach that included local functional connectivity density (FCD) analysis combined with multivariate pattern analysis (MVPA) was used to compare the three groups...
August 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28367127/alterations-of-intrinsic-brain-connectivity-patterns-in-depression-and-bipolar-disorders-a-critical-assessment-of-magnetoencephalography-based-evidence
#10
REVIEW
Golnoush Alamian, Ana-Sofía Hincapié, Etienne Combrisson, Thomas Thiery, Véronique Martel, Dmitrii Althukov, Karim Jerbi
Despite being the object of a thriving field of clinical research, the investigation of intrinsic brain network alterations in psychiatric illnesses is still in its early days. Because the pathological alterations are predominantly probed using functional magnetic resonance imaging (fMRI), many questions about the electrophysiological bases of resting-state alterations in psychiatric disorders, particularly among mood disorder patients, remain unanswered. Alongside important research using electroencephalography (EEG), the specific recent contributions and future promise of magnetoencephalography (MEG) in this field are not fully recognized and valued...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28342970/not-in-one-metric-neuroticism-modulates-different-resting-state-metrics-within-distinctive-brain-regions
#11
Claudio Gentili, Ioana Alina Cristea, Emiliano Ricciardi, Nicola Vanello, Cristian Popita, Daniel David, Pietro Pietrini
INTRODUCTION: Neuroticism is a complex personality trait encompassing diverse aspects. Notably, high levels of neuroticism are related to the onset of psychiatric conditions, including anxiety and mood disorders. Personality traits are stable individual features; therefore, they can be expected to be associated with stable neurobiological features, including the Brain Resting State (RS) activity as measured by fMRI. Several metrics have been used to describe RS properties, yielding rather inconsistent results...
June 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28337552/clinical-utility-of-resting-state-functional-connectivity-magnetic-resonance-imaging-for-mood-and-cognitive-disorders
#12
REVIEW
T Takamura, T Hanakawa
Although functional magnetic resonance imaging (fMRI) has long been used to assess task-related brain activity in neuropsychiatric disorders, it has not yet become a widely available clinical tool. Resting-state fMRI (rs-fMRI) has been the subject of recent attention in the fields of basic and clinical neuroimaging research. This method enables investigation of the functional organization of the brain and alterations of resting-state networks (RSNs) in patients with neuropsychiatric disorders. Rs-fMRI does not require participants to perform a demanding task, in contrast to task fMRI, which often requires participants to follow complex instructions...
March 23, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28291247/enhancing-studies-of-the-connectome-in-autism-using-the-autism-brain-imaging-data-exchange-ii
#13
Adriana Di Martino, David O'Connor, Bosi Chen, Kaat Alaerts, Jeffrey S Anderson, Michal Assaf, Joshua H Balsters, Leslie Baxter, Anita Beggiato, Sylvie Bernaerts, Laura M E Blanken, Susan Y Bookheimer, B Blair Braden, Lisa Byrge, F Xavier Castellanos, Mirella Dapretto, Richard Delorme, Damien A Fair, Inna Fishman, Jacqueline Fitzgerald, Louise Gallagher, R Joanne Jao Keehn, Daniel P Kennedy, Janet E Lainhart, Beatriz Luna, Stewart H Mostofsky, Ralph-Axel Müller, Mary Beth Nebel, Joel T Nigg, Kirsten O'Hearn, Marjorie Solomon, Roberto Toro, Chandan J Vaidya, Nicole Wenderoth, Tonya White, R Cameron Craddock, Catherine Lord, Bennett Leventhal, Michael P Milham
The second iteration of the Autism Brain Imaging Data Exchange (ABIDE II) aims to enhance the scope of brain connectomics research in Autism Spectrum Disorder (ASD). Consistent with the initial ABIDE effort (ABIDE I), that released 1112 datasets in 2012, this new multisite open-data resource is an aggregate of resting state functional magnetic resonance imaging (MRI) and corresponding structural MRI and phenotypic datasets. ABIDE II includes datasets from an additional 487 individuals with ASD and 557 controls previously collected across 16 international institutions...
March 14, 2017: Scientific Data
https://www.readbyqxmd.com/read/28287187/similarities-and-differences-of-functional-connectivity-in-drug-na%C3%A3-ve-first-episode-adolescent-and-young-adult-with-major-depressive-disorder-and-schizophrenia
#14
Shengnan Wei, Fay Womer, Haiyang Geng, Xiaowei Jiang, Qian Zhou, Miao Chang, Yifang Zhou, Yanqing Tang, Fei Wang
Major depressive disorder (MDD) and schizophrenia (SZ) are considered two distinct psychiatric disorders. Yet, they have considerable overlap in symptomatology and clinical features, particularly in the initial phases of illness. The amygdala and prefrontal cortex (PFC) appear to have critical roles in these disorders; however, abnormalities appear to manifest differently. In our study forty-nine drug-naïve, first-episode MDD, 45 drug-naïve, first-episode SZ, and 50 healthy control (HC) participants from 13 to 30 years old underwent resting-state functional magnetic resonance imaging...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28274468/development-of-white-matter-microstructure-and-intrinsic-functional-connectivity-between-the-amygdala-and-ventromedial-prefrontal-cortex-associations-with-anxiety-and-depression
#15
Maria Jalbrzikowski, Bart Larsen, Michael N Hallquist, William Foran, Finnegan Calabro, Beatriz Luna
BACKGROUND: Connectivity between the amygdala and ventromedial prefrontal cortex (vmPFC) is compromised in multiple psychiatric disorders, many of which emerge during adolescence. To identify to what extent the deviations in amygdala-vmPFC maturation contribute to the onset of psychiatric disorders, it is essential to characterize amygdala-vmPFC connectivity changes during typical development. METHODS: Using an accelerated cohort longitudinal design (1-3 time points, 10-25 years old, n = 246), we characterized developmental changes of the amygdala-vmPFC subregion functional and structural connectivity using resting-state functional magnetic resonance imaging and diffusion-weighted imaging...
January 17, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28265121/brain-structural-and-functional-signatures-of-impulsive-compulsive-behaviours-in-parkinson-s-disease
#16
F Imperiale, F Agosta, E Canu, V Markovic, A Inuggi, M Jecmenica-Lukic, A Tomic, M Copetti, S Basaia, V S Kostic, M Filippi
This study assessed brain structural and functional alterations in patients with Parkinson's disease and impulsive-compulsive behaviours (PD-ICB) compared with controls and PD no-ICB cases. Eighty-five PD patients (35 PD-ICB) and 50 controls were recruited. All subjects underwent three-dimensional T1-weighted, diffusion tensor (DT), and resting state functional magnetic resonance imaging (RS fMRI). We assessed cortical thickness with surface-based morphometry, subcortical volumes using FIRST, DT MRI metrics using region of interest and tractography approaches, and RS fMRI using a model free approach...
March 7, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28256777/utility-of-the-cumulative-stress-and-mismatch-hypotheses-in-understanding-the-neurobiological-impacts-of-childhood-abuse-and-recent-stress-in-youth-with-emerging-mental-disorder
#17
Casey Paquola, Maxwell R Bennett, Sean N Hatton, Daniel F Hermens, Jim Lagopoulos
Childhood abuse has an enduring impact on the brain's stress system. Whether the effects of childhood abuse and adulthood stress are additive (cumulative stress hypothesis) or interactive (mismatch hypothesis) is widely disputed, however. The primary aim of this study was to test the utility of the cumulative stress and mismatch hypotheses in understanding brain and behaviour. We recruited 64 individuals (aged 14-26) from a specialised clinic for assessment and early intervention of mental health problems in young people...
March 3, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28231395/functional-connectivity-in-amygdalar-sensory-pre-motor-networks-at-rest-new-evidence-from-the-human-connectome-project
#18
Nicola Toschi, Andrea Duggento, Luca Passamonti
The word 'e-motion' derives from the Latin word 'ex-moveo' which literally means 'moving away from something/somebody'. Emotions are thus fundamental to prime action and goal-directed behavior with obvious implications for individual's survival. However, the brain mechanisms underlying the interactions between emotional and motor cortical systems remain poorly understood. A recent diffusion tensor imaging study in humans has reported the existence of direct anatomical connections between the amygdala and sensory/(pre)motor cortices, corroborating an initial observation in animal research...
February 23, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28167349/proportional-thresholding-in-resting-state-fmri-functional-connectivity-networks-and-consequences-for-patient-control-connectome-studies-issues-and-recommendations
#19
Martijn P van den Heuvel, Siemon C de Lange, Andrew Zalesky, Caio Seguin, B T Thomas Yeo, Ruben Schmidt
Graph theoretical analysis has become an important tool in the examination of brain dysconnectivity in neurological and psychiatric brain disorders. A common analysis step in the construction of the functional graph or network involves "thresholding" of the connectivity matrix, selecting the set of edges that together form the graph on which network organization is evaluated. To avoid systematic differences in absolute number of edges, studies have argued against the use of an "absolute threshold" in case-control studies and have proposed the use of "proportional thresholding" instead, in which a pre-defined number of strongest connections are selected as network edges, ensuring equal network density across datasets...
February 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28157095/functional-connectivity-in-the-default-mode-network-is-reduced-in-association-with-nocturnal-awakening-in-mild-cognitive-impairment
#20
Andrew C McKinnon, Shantel L Duffy, Nathan E Cross, Zoe Terpening, Ron R Grunstein, Jim Lagopoulos, Jennifer Batchelor, Ian B Hickie, Simon J G Lewis, James M Shine, Sharon L Naismith
BACKGROUND: Sleep disturbance is prevalent in MCI, and is a risk factor for cognitive deterioration. OBJECTIVE: To identify functional connectivity deficits in the default mode network (DMN) in patients with mild cognitive impairment (MCI) and sleep disturbance, relative to MCIs with intact sleep. METHODS: Participants comprised 47 adults aged 55 years and over, recruited from the Healthy Brain Ageing Clinic at the Brain and Mind Centre, Sydney, Australia...
2017: Journal of Alzheimer's Disease: JAD
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