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https://www.readbyqxmd.com/read/29909860/outcomes-and-associated-factors-in-malpractice-litigation-involving-inferior-vena-cava-filters
#1
REVIEW
Kenny Oh, Anil Hingorani
OBJECTIVE: Placement of inferior vena cava (IVC) filters is a controversial focus of medical malpractice. Clinicians currently have little information to guide them regarding key issues and outcomes in litigation. In this retrospective legal case review, we analyzed the factors associated with malpractice actions involving IVC filters. METHODS: The legal databases LexisNexis and Westlaw were searched from 1967 to 2016 for all published legal cases in the United States involving placement of IVC filters...
July 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29904963/experience-of-a-single-center-in-the-conservative-approach-of-20-consecutive-cases-of-asymptomatic-extracranial-carotid-artery-aneurysms
#2
V E C Pourier, J C Welleweerd, L J Kappelle, G J E Rinkel, Y M Ruigrok, H B van der Worp, T H Lo, M L Bots, F L Moll, Gert J de Borst
BACKGROUND: The clinical course and optimal treatment strategy for asymptomatic aneurysms of the extracranial carotid artery (ECAA) are unknown. We report our single-center experience with conservative management of patients with an asymptomatic ECAA. METHODS: A search in our hospital records from 1998 to 2013 revealed 20 patients (mean age 52 years, SD 12.5) with 23 ECAA, defined as a 150% or more fusiform dilation or any saccular dilatation compared to the healthy internal carotid artery...
June 14, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29894004/generic-antiepileptic-drugs-safe-or-harmful-in-patients-with-epilepsy
#3
Martin Holtkamp, William H Theodore
Generic antiepileptic drugs (AED) are significantly cheaper than brand name drugs, and may reduce overall health care expenditures. Regulatory bodies in Europe and North America require bioequivalence between generic and innovator drugs with regard to area under the plasma concentration-time curve (AUC) and peak plasma concentration (Cmax ); strict cutoff values have been defined. The main issue is if bioequivalence ensures therapeutic equivalence. Are switches from brand to generic, or between generic AEDs entirely safe or potentially harmful in patients with epilepsy? We summarized and evaluated the available evidence from bioequivalence, health care utilization, and clinical studies on safety of generic AEDs...
June 12, 2018: Epilepsia
https://www.readbyqxmd.com/read/29891587/characterization-of-the-neurochemical-and-behavioral-effects-of-solriamfetol-jzp-110-a-selective-dopamine-and-norepinephrine-reuptake-inhibitor
#4
Michelle G Baladi, Michael J Forster, Michael B Gatch, Richard B Mailman, Danielle L Hyman, Lawrence P Carter, Aaron J Janowsky
Excessive sleepiness (ES) is associated with several sleep disorders, including narcolepsy and obstructive sleep apnea (OSA). A role for monoaminergic systems in treating these conditions is highlighted by the clinical use of United States Food and Drug Administration-approved drugs that act on these systems, such as dextroamphetamine, methylphenidate, modafinil, and armodafinil. Solriamfetol (JZP-110) is a wake-promoting agent that is currently being evaluated to treat ES in patients with narcolepsy or OSA...
June 11, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29873710/assessing-the-relationship-between-healthcare-market-competition-and-medical-care-quality-under-taiwan-s-national-health-insurance-programme
#5
Chih-Hsien Liao, Ning Lu, Chao-Hsiun Tang, Hui-Chih Chang, Kuo-Cherh Huang
Background: There is still significant uncertainty as to whether market competition raises or lowers clinical quality in publicly funded healthcare systems. We attempted to assess the effects of market competition on inpatient care quality of stroke patients in a retrospective study of the universal single-payer health insurance system in Taiwan. Methods: In this 11-year population-based study, we conducted a pooled time-series cross-sectional analysis with a fixed-effects model and the Hausman test approach by utilizing two nationwide datasets: the National Health Insurance Research Database and the National Hospital and Services Survey in Taiwan...
June 4, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29808632/lumbar-canal-stenosis-can-we-treat-it-endoscopically-our-experience
#6
Leonello Tacconi, Roberto Spinelli
BACKGROUND: The common treatment for lumbar canal stenosis involves an open surgical decompression with laminectomy and foraminotomy, even if spinal surgery is moving towards minimal invasiveness procedures. Minimal Invasive Surgery initially and recently spinal endoscopic techniques are becoming the standard procedures for lumbar disk prolapsed in consideration of the less surgical invasiveness with a considerable reducing in the amount of normal anatomy violation, in less risk of iatrogenic post-operative instability, minimal scar tissue formation and negligible blood loss when compared to the standard open approach...
May 28, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29794517/measuring-mindsets-and-achievement-goal-motivation-a-validation-study-of-three-instruments
#7
David A Cook, Becca L Gas, Anthony R Artino
PURPOSE: To evaluate the validity of scores from three instruments measuring achievement goal motivation-related constructs: a shortened version of Dweck's Implicit Theories of Intelligence Scale (ITIS-S), measuring incremental and entity mindsets; Elliot's Achievement Goal Questionnaire-Revised (AGQ-R), measuring mastery-approach, mastery-avoidance, performance-approach, and performance-avoidance achievement goals; and Midgley's Patterns of Adaptive Learning Scales (PALS), measuring mastery, performance-approach, and performance-avoidance achievement goals...
May 22, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29791711/percutaneous-edge-to-edge-transcatheter-mitral-valve-repair-current-indications-and-future-perspectives
#8
Martino Pepe, Emanuela De Cillis, Tommaso Acquaviva, Annagrazia Cecere, Pasquale D'Alessandro, Arturo Giordano, Marco Matteo Ciccone, Alessandro Santo Bortone
Mitral regurgitation (MR) is the most prevalent valvular heart disease (VHD) and represents an important cause of heart failure. Medical therapy has a limited role in improving symptoms and does not hinder the progression of valvular disease. Surgery is the treatment of choice for severe symptomatic MR; valve repair is currently the preferred surgical approach because it reduces peri-operative mortality and ensures a good medium- to long-term survival outcome. Nevertheless, a non-negligible proportion of patients with indications for surgical correction are considered to be at prohibitive perioperative risk, mainly because of old age and multiple comorbidities...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29681886/importance-of-collateralization-in-patients-with-large-artery-intracranial-occlusive-disease-long-term-longitudinal-assessment-of-cerebral-hemodynamic-function
#9
Larissa McKetton, Lakshmikumar Venkatraghavan, Julien Poublanc, Olivia Sobczyk, Adrian P Crawley, Casey Rosen, Frank L Silver, James Duffin, Joseph A Fisher, David J Mikulis
Patients with large artery intracranial occlusive disease (LAICOD) are at risk for both acute ischemia and chronic hypoperfusion. Collateral circulation plays an important role in prognosis, and imaging plays an essential role in diagnosis, treatment planning, and prognosis of patients with LAICOD. In addition to standard structural imaging, assessment of cerebral hemodynamic function is important to determine the adequacy of collateral supply. Among the currently available methods of assessment of cerebral hemodynamic function, measurement of cerebrovascular reactivity (CVR) using blood oxygen level-dependent (BOLD) MRI and precisely controlled CO2 has shown to be a safe, reliable, reproducible, and clinically useful method for long-term assessment of patients...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29678488/medicolegal-considerations-involving-iatrogenic-lingual-nerve-damage
#10
REVIEW
Roberto Pippi, Andrea Spota, Marcello Santoro
The aim of this review is to improve risk management strategies through analysis of the anatomic, semeiotic, and medicolegal aspects that characterize iatrogenic lingual nerve damage (LND) and its legal consequences in the case of legal proceedings for a claim for compensation. In dental practice, LND can be caused by local or general anesthesia or by mechanical, chemical, or thermal mechanisms. A certain postoperative identification of LND etiopathogenesis is often very challenging because it can be difficult to show at what time the damage occurred and which mechanism actually caused it...
March 27, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29662295/should-hot-biopsy-forceps-be-abandoned-for-polypectomy-of-diminutive-colorectal-polyps
#11
Vasileios Panteris, Antonios Vezakis, J K Triantafillidis
Standardized approach to polypectomy of diminutive colorectal polyps (DCPs) is lacking since cold biopsy forceps have been associated with high levels of recurrence, hot biopsy forceps are considered inadequate and risky and cold snaring is currently under investigation for its efficacy and safety. This has led to confusion and a gap in clinical practice. This article discusses the usefulness and contemporary practical applicability of hot biopsy forceps and provides well-intentioned criticism of the new European guidelines for the treatment of DCPs...
April 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29658049/a-simple-microfluidic-platform-for-rapid-and-efficient-production-of-the-radiotracer-18-f-fallypride
#12
Xin Zhang, Fei Liu, Karla-Anne Knapp, Michael L Nickels, H Charles Manning, Leon M Bellan
Herein, we report the development of a simple, high-throughput and efficient microfluidic system for synthesizing radioactive [18F]fallypride, a PET imaging radiotracer widely used in medical research. The microfluidic chip contains all essential modules required for the synthesis and purification of radioactive fallypride. The radiochemical yield of the tracer is sufficient for multiple animal injections for preclinical imaging studies. To produce the on-chip concentration and purification columns, we employ a simple "trapping" mechanism by inserting rows of square pillars with predefined gaps near the outlet of microchannel...
May 1, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29627916/necrotizing-fasciitis-case-series-and-review-of-the-literature-on-clinical-and-medico-legal-diagnostic-challenges
#13
Paolo Fais, Alessia Viero, Guido Viel, Renzo Giordano, Dario Raniero, Stefano Kusstatscher, Chiara Giraudo, Giovanni Cecchetto, Massimo Montisci
Necrotizing fasciitis (NF) is a life-threatening infection of soft tissues spreading along the fasciae to the surrounding musculature, subcutaneous fat and overlying skin areas that can rapidly lead to septic shock and death. Due to the pandemic increase of medical malpractice lawsuits, above all in Western countries, the forensic pathologist is frequently asked to investigate post-mortem cases of NF in order to determine the cause of death and to identify any related negligence and/or medical error. Herein, we review the medical literature dealing with cases of NF in a post-mortem setting, present a case series of seven NF fatalities and discuss the main ante-mortem and post-mortem diagnostic challenges of both clinical and forensic interests...
April 7, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29604509/the-role-of-the-size-and-location-of-the-tumors-and-of-the-vertebral-anatomy-in-determining-the-structural-stability-of-the-metastatically-involved-spine-a-finite-element-study
#14
Fabio Galbusera, Zhihui Qian, Gloria Casaroli, Tito Bassani, Francesco Costa, Benedikt Schlager, Hans-Joachim Wilke
Vertebral fractures associated with the loss of structural integrity of neoplastic vertebrae are common, and determined to the deterioration of the bone quality in the lesion area. The prediction of the fracture risk in metastatically involved spines can guide in deciding if preventive solutions, such as medical prophylaxis, bracing, or surgery are indicated for the patient. In this study, finite element models of 22 thoracolumbar vertebrae were built based on CT scans of three spines, covering a wide spectrum of possible clinical scenarios in terms of age, bone quality and degenerative features, taking into account the local material properties of bone tissue...
June 2018: Translational Oncology
https://www.readbyqxmd.com/read/29572339/-montgomery-informed-consent-and-causation-of-harm-lessons-from-australia-or-a-uniquely-english-approach-to-patient-autonomy
#15
Malcolm K Smith, Tracey Carver
The UK Supreme Court in Montgomery v Lanarkshire Health Board adopts an approach to information disclosure in connection with clinical treatment that moves away from medical paternalism towards a more patient-centred approach. In doing so, it reinforces the protection afforded to informed consent and autonomous patient decision making under the law of negligence. However, some commentators have expressed a concern that the widening of the healthcare providers' duty of disclosure may provide impetus, in future cases, for courts to adopt a more rigorous approach to the application of causation principles...
June 2018: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29531613/knowledge-and-preparedness-of-dental-practitioners-on-management-of-medical-emergencies-in-jazan-province
#16
Ghassan M Al-Iryani, Fareedi Mukram Ali, Naima H Alnami, Sahar K Almashhur, Maha A Adawi, Abrar A Tairy
Medical emergencies are one of the most stressful situations the staff in a dental practice might encounter. The duty of care toward the attending patients obligates suitable preparedness to provide the necessary care if such emergencies ensue. Unfortunately, we found that 22% of the investigated dental clinics had no emergency kit available. Only 38% of the interviewed dentists felt confident to perform CPR, and 18% had no confidence to manage any medical emergency. An MCQ test of 20 questions examining the dentists' knowledge in medical emergencies was distributed, and the level of knowledge was found to be suboptimal...
February 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29492556/a-waveform-archiving-system-for-the-ge-solar-8000i-bedside-monitor
#17
Andrea Fanelli, Rohan Jaishankar, Aristotelis Filippidis, James Holsapple, Thomas Heldt
OBJECTIVES:  Our objective was to develop, deploy, and test a data-acquisition system for the reliable and robust archiving of high-resolution physiological waveform data from a variety of bedside monitoring devices, including the GE Solar 8000i patient monitor, and for the logging of ancillary clinical and demographic information. MATERIALS AND METHODS:  The data-acquisition system consists of a computer-based archiving unit and a GE Tram Rac 4A that connects to the GE Solar 8000i monitor...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29457203/challenges-and-opportunities-in-establishing-and-maintaining-newborn-screening-in-a-rural-area-of-andhra-pradesh-task-force-study-by-indian-council-of-medical-research
#18
A Radha Rama Devi, Y Ananthalakshmi, K Srimannarayana Rao
OBJECTIVE: The primary objective was to evaluate the feasibility of setting up newborn screening in rural areas in India. Secondary objective was to enhance the knowledge and awareness towards early detection of diseases by newborn screening, management of the affected baby and to impart genetic counseling. METHODS: Awareness programs were conducted at different mandals in the district for the medical practioners during the preparatory phase of the Task Force Project...
February 19, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29424474/a-critical-review-of-the-application-of-polymer-of-low-concern-and-regulatory-criteria-to-fluoropolymers
#19
REVIEW
Barbara J Henry, Joseph P Carlin, Jon A Hammerschmidt, Robert C Buck, L William Buxton, Heidelore Fiedler, Jennifer Seed, Oscar Hernandez
Per- and polyfluoroalkyl substances (PFAS) are a group of fluorinated substances that are in the focus of researchers and regulators due to widespread presence in the environment and biota, including humans, of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). Fluoropolymers, high molecular weight polymers, have unique properties that constitute a distinct class within the PFAS group. Fluoropolymers have thermal, chemical, photochemical, hydrolytic, oxidative, and biological stability. They have negligible residual monomer and oligomer content and low to no leachables...
May 2018: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/29413639/biotin-and-acetazolamide-for-treatment-of-an-unusual-child-with-autism-plus-lack-of-nail-and-hair-growth
#20
Paul J Benke, Michael Duchowny, Dianalee McKnight
BACKGROUND: Patients with autism spectrum disorder and developmental delay or encephalopathy rarely demonstrate no or negligible hair and nail growth, suggesting a biotin-responsive clinical disorder. METHODS: A ten-year-old girl presented with features of autism spectrum disorder, isolated headaches, and episodes of headaches and limb shaking. Her medical history revealed that her hair and nails did not grow. Administration of biotin restored her nail and hair growth and improved intellectual ability and school performance...
February 2018: Pediatric Neurology
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