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https://www.readbyqxmd.com/read/29457203/challenges-and-opportunities-in-establishing-and-maintaining-newborn-screening-in-a-rural-area-of-andhra-pradesh-task-force-study-by-indian-council-of-medical-research
#1
A Radha Rama Devi, Y Ananthalakshmi, K Srimannarayana Rao
OBJECTIVE: The primary objective was to evaluate the feasibility of setting up newborn screening in rural areas in India. Secondary objective was to enhance the knowledge and awareness towards early detection of diseases by newborn screening, management of the affected baby and to impart genetic counseling. METHODS: Awareness programs were conducted at different mandals in the district for the medical practioners during the preparatory phase of the Task Force Project...
February 19, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29424474/a-critical-review-of-the-application-of-polymer-of-low-concern-and-regulatory-criteria-to-fluoropolymers
#2
REVIEW
Barbara J Henry, Joseph P Carlin, Jon A Hammerschmidt, Robert C Buck, L William Buxton, Heidelore Fiedler, Jennifer Seed, Oscar Hernandez
Per- and poly-fluoroalkyl substances (PFAS) are a group of fluorinated substances that are in the focus of researchers and regulators due to widespread presence in the environment and biota, including humans, of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). Fluoropolymers, high molecular weight polymers within the PFAS group, have unique properties that constitute a distinct class within the PFAS group. Fluoropolymers have thermal, chemical, photochemical, hydrolytic, oxidative and biological stability...
February 9, 2018: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/29413639/biotin-and-acetazolamide-for-treatment-of-an-unusual-child-with-autism-plus-lack-of-nail-and-hair-growth
#3
Paul J Benke, Michael Duchowny, Dianalee McKnight
BACKGROUND: Patients with autism spectrum disorder and developmental delay or encephalopathy rarely demonstrate no or negligible hair and nail growth, suggesting a biotin-responsive clinical disorder. METHODS: A ten-year-old girl presented with features of autism spectrum disorder, isolated headaches, and episodes of headaches and limb shaking. Her medical history revealed that her hair and nails did not grow. Administration of biotin restored her nail and hair growth and improved intellectual ability and school performance...
February 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29390862/financial-incentives-for-chronic-disease-management-results-and-limitations-of-2-randomized-clinical-trials-with-new-york-medicaid-patients
#4
Eric M VanEpps, Andrea B Troxel, Elizabeth Villamil, Kathryn A Saulsgiver, Jingsan Zhu, Jo-Yu Chin, Jacqueline Matson, Joseph Anarella, Patrick Roohan, Foster Gesten, Kevin G Volpp
PURPOSE: To identify whether financial incentives promote improved disease management in Medicaid recipients diagnosed with hypertension or diabetes, respectively. DESIGN: Four-group, multicenter, randomized clinical trials. SETTING AND PARTICIPANTS: Between 2013 and 2016, New York State Medicaid managed care members diagnosed with hypertension (N = 920) or with diabetes (N = 959). INTERVENTION: Participants in each 6-month trial were randomly assigned to 1 of 4 arms: (1) process incentives-earned by attending primary care visits and/or receiving prescription medication refills, (2) outcome incentives-earned by reducing systolic blood pressure (hypertension) or hemoglobin A1c (HbA1c; diabetes) levels, (3) combined process and outcome incentives, and (4) control (no incentives)...
January 1, 2018: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29379382/indicators-for-medical-mistrust-in-healthcare-a-review-and-standpoint-from-southeast-asia
#5
REVIEW
Hew Hei Choy, Aniza Ismail
The relationship based on trust is exceptionally important in healthcare, where life or death and quality of health are major concerns. Relational crack jeopardises the provision of quality healthcare when trust is taken for granted. Trust is believed to be the vital key to minimise medical negligence, lawsuits and patient complaints towards healthcare providers while acting as an empowering agent to significant clinical outcomes. Trust is indispensable to healthcare. However, to identify its deterioration is not a simple feature...
December 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/29361180/prevalence-of-burnout-among-pain-medicine-physicians-and-its-potential-effect-upon-clinical-outcomes-in-patients-with-oncologic-pain-or-chronic-pain-of-nononcologic-origin
#6
Irene Riquelme, José-Ignacio Chacón, Alba-Violeta Gándara, Inmaculada Muro, Susana Traseira, Vicente Monsalve, José-Francisco Soriano
Objective: To evaluate the prevalence of burnout among physicians treating patients with chronic pain and to assess the potential relationships between the presence of burnout and patients' clinical outcomes such as pain relief, satisfaction with pain control, and quality of life. Design: An observational, prospective, and noncomparative study. Setting: Pain medicine clinics. Subjects: Physicians from medical departments involved in the management of chronic pain...
January 19, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29359673/non-traditional-cardiovascular-risk-markers-in-the-era-of-established-major-risk-factors-and-multiple-guidelines
#7
Thomas F Whayne
The non-traditional cardiovascular (CV) risk factors that appear to be of most clinical interest include: apolipoprotein A (ApoA), apolipoprotein B (ApoB), high-sensitivity C-Reactive protein (hsCRP), homocysteine, interleukin 1 (IL1), lipoprotein (a) [Lp(a)], the density of low-density lipoprotein (LDL) particles, the LDL particle number, tissue/tumor necrosis factor-α (TNF-α) and uric acid. These non-traditional risk factors may be of value in adding further confirmation and attention to suspected significant CV risk...
January 22, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29343085/a-lack-of-systemic-absorption-following-the-repeated-application-of-topical-quetiapine-in-healthy-adults
#8
Bryce Kayhart, Maria I Lapid, Sarah Nelson, Julie L Cunningham, Virginia H Thompson, Jonathan G Leung
In the absence of suitable oral or intravenous access for medication administration and when the intramuscular medications are undesirable, alternative routes for drug delivery may be considered. Antipsychotics administered via an inhaled, intranasal, rectal, or topical route have been described in the literature. Topically administered antipsychotics have been previously reported to produce negligible systemic absorption despite being used in clinical practice for nausea and behavioral symptoms associated with dementia...
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29290546/characteristics-of-claims-in-the-management-of-septic-arthritis-in-japan-retrospective-analyses-of-judicial-precedents-and-closed-claims
#9
Yasuhiro Otaki, Makiko Ishida DaSilva, Yuichi Saito, Yasuaki Oyama, Giichiro Oiso, Tomohiko Yoshida, Masakazu Fukuhara, Mitsuru Moriyama
BACKGROUND: Septic arthritis (SA) cases can result in claims or litigation because of poor prognosis even if it is unavoidable. Although these claims or litigation are useful for understanding causes and background factors of medical errors, the characteristics of malpractice claims associated with SA remain undetermined in Japan. This study aimed to increase our understanding of malpractice claims in the clinical management of SA. METHODS: We analyzed 6 civil precedents and 16 closed claims of SA from 8530 malpractice claims processed between July 2004 and June 2014 by the Tokyo office of Sompo Japan Nipponkoa Insurance, Incorporated...
December 28, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29241615/provision-of-medical-supply-kits-to-improve-quality-of-antenatal-care-in-mozambique-a-stepped-wedge-cluster-randomised-trial
#10
Ana Pilar Betrán, Eduardo Bergel, Sally Griffin, Armando Melo, My Huong Nguyen, Alicia Carbonell, Santos Mondlane, Mario Merialdi, Marleen Temmerman, A Metin Gülmezoglu
BACKGROUND: High levels of maternal and newborn mortality and morbidity remain a daunting reality in many low-income countries. Several interventions delivered during antenatal care have been shown to improve maternal and newborn outcomes, but stockouts of medical supplies at point of care can prevent implementation of these services. We aimed to evaluate whether a supply chain strategy based on the provision of kits could improve quality of care. METHODS: We did a pragmatic, stepped-wedge, cluster-randomised controlled trial at ten antenatal care clinics in Mozambique...
January 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29196112/long-term-outcomes-and-prognostic-factors-in-patients-with-mild-hemoptysis
#11
Joonsung Choi, Jun Hyun Baik, Chi Hong Kim, So Hyang Song, Sung Kyung Kim, Myeongjong Kim, Sungeun Yun
OBJECTIVE: The aim of this retrospective study was to observe the long-term outcomes of conservative treatment and bronchial artery embolization (BAE) in patients with mild hemoptysis and to analyze the risk factors associated with hemoptysis recurrence. METHODS: Patients with mild hemoptysis from January 2005 to January 2016 were enrolled in this study. The patients' medical records, including smoking history, etiologic diseases, bronchoscopic findings, mortality, BAE information, and follow-up data of recurrent hemoptysis, were reviewed and analyzed...
November 27, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29185542/pimavanserin-a-novel-therapeutic-option-for-parkinson-disease-psychosis
#12
REVIEW
Trevor Hawkins, Brian D Berman
Purpose of review: In April 2016, the Food and Drug Administration (FDA) approved a first-in-class atypical antipsychotic medication called pimavanserin for the treatment of Parkinson disease psychosis (PDP). We aim to inform readers about its indications, effectiveness, and safety profile. Recent findings: Pimavanserin acts as an inverse agonist at serotonin 5-HT2A receptors and has negligible effects on other receptors, thereby avoiding the D2 receptor antagonism that can potentially worsen motor symptoms...
April 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29152753/the-hospital-otolaryngologist-the-louisiana-state-university-experience
#13
Phillip G Allen, Laura T Hetzler, Daniel W Nuss, Rohan R Walvekar, Gretchen Penton, Elona Sharbaugh
OBJECTIVES/HYPOTHESIS: To describe the implementation and impact of a hospital otolaryngologist in an academic medical center setting. Our hypothesis was that the hospital otolaryngologist would increase productivity of the Louisiana State University (LSU) faculty otolaryngologists and provide more timely access to inpatient otolaryngology services. STUDY DESIGN: Retrospective clinical and administrative database review. METHODS: A comparative database review was performed with data from the year predating the initiation of the hospitalist program (2013) to the first full year after initiation of the program (2014)...
November 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29138537/development-of-novel-ultrashort-antimicrobial-peptide-nanoparticles-with-potent-antimicrobial-and-antibiofilm-activities-against-multidrug-resistant-bacteria
#14
Ammar Almaaytah, Gubran Khalil Mohammed, Ahmad Abualhaijaa, Qosay Al-Balas
Conventional antibiotics are facing strong microbial resistance that has recently reached critical levels. This situation is leading to significantly reduced therapeutic potential of a huge proportion of antimicrobial agents currently used in clinical settings. Antimicrobial peptides (AMPs) could provide the medical community with an alternative strategy to traditional antibiotics for combating microbial resistance. However, the development of AMPs into clinically useful antibiotics is hampered by their relatively low stability, toxicity, and high manufacturing costs...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29136185/cognitive-dysfunction-among-newly-diagnosed-older-patients-with-hematological-malignancy-frequency-clinical-indicators-and-predictors
#15
Sayo Aiki, Toru Okuyama, Koji Sugano, Yosuke Kubota, Fuminobu Imai, Masahiro Nishioka, Yoshinori Ito, Shinsuke Iida, Hirokazu Komatsu, Takashi Ishida, Shigeru Kusumoto, Tatsuo Akechi
Background: Medical staff often overlook or underestimate the presence or severity of cognitive dysfunction. The purpose of this study was to clarify the frequency, clinical indicators and predictors of cognitive dysfunction among newly diagnosed older patients with hematologic malignancy receiving first-line chemotherapy. Methods: Patients aged 65 years or over with a primary diagnosis of malignant lymphoma or multiple myeloma were consecutively recruited. Cognitive dysfunction was evaluated using the Mini-Mental State Examination (MMSE) twice: before starting chemotherapy (T1) and 1 month later (T2)...
November 10, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29108867/medicolegal-issues-for-the-respiratory-paediatrician
#16
REVIEW
Ian M Balfour-Lynn
The legal profession depends on expert witnesses, and indeed the first time an English Court relied on an expert medical witness was in the 14th century. Asking a specialist to comment on the standard of professional practice expected in their own specialty was first introduced in a 1767 case [1]. This article draws on 20 years of experience in medicolegal work relating to paediatric respiratory medicine. It highlights some of the legal principles that lie behind an expert opinion and what constitutes clinical negligence...
October 12, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29083339/reoperation-for-persistent-or-recurrent-secondary-hyperparathyroidism
#17
Alida Abruzzo, Maria Concetta Gioviale, Giuseppe Damiano, Vincenzo Davide Palumbo, Salvatore Buscemi, Giulia Lo Monte, Leonardo Gulotta, Giuseppe Buscemi, Attilio Ignazio Lo Monte
BACKGROUND: Secondary hyperparathyroidism is a common acquired disorder seen in chronic renal failure. Its pathophysiology is mainly due to hyperphosphatemia and vitamin D deficiency and resistance. When medical treatment fails, subtotal and total parathyroidectomy with autotransplantation are the standard procedures, although both are associated with high recurrence rates. METHODS AND RESULTS: 4 patients experienced persistence and 9 relapse. The first 4 were subjected to reoperation after 6 months for the persistence of symptoms due to the finding of a supernumerary adenomatous gland while the remaining patients at the reoperation showed in 5 cases 2 more glands in over thymic position, and 4 an hyperplasia of the residual glandular tissue...
October 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29027632/let-us-talk-about-eggs-professional-resistance-to-elective-egg-vitrification-and-gendered-medical-paternalism
#18
Judit Sándor, Lilla Vicsek, Zsófia Bauer
In this paper, by applying a feminist bioethical perspective, we identify a new form of medical paternalism that still shapes contemporary legal policies on human egg cryopreservation performed without medical reasons. The fear of negligent, careless women who opt to delay their pregnancy for mere convenience is a widely known gender biased stereotype. Nevertheless, the opinions and judgments of medical professionals on this issue have not yet been sufficiently explored by in-depth research. In this essay, therefore, first we look at the broader bioethical, legal, and social aspects of human egg cryopreservation...
October 13, 2017: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/29016595/reporting-of-medical-errors-in-autopsied-cases
#19
Bikash Sah, B N Yadav, Shivendra Jha, Ashok Ayer, Ajay Kumar Yadav
This report describes the cases autopsied at B. P. Koirala Institute of Health Sciences- Nepal, during the period of two years in which the treatment provided falls below the accepted standard practice causing the death of the patient. Postmortem examination provides an opportunity to find out the actual cause of death in which the cause of death is suspicious. Sometimes the cause of death found through postmortem examination is different from the clinical cause of death. The autopsy finding on the cause of death will help doctors even to think about unusual conditions that lead to death and hence apply preventive measures for those unusual conditions...
September 8, 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28976414/adjuvant-stromal-amphotericin-b-injection-for-late-onset-dmek-infection
#20
Elmer Y Tu, Parag A Majmudar
PURPOSE: To report the successful medical management of a late-onset Descemet membrane endothelial keratoplasty (DMEK)-related interface infection. METHODS: A case of DMEK endothelial keratoplasty-related infection treated with intrastromal antifungal injection was identified. The following information was collected: demographic data, surgical indications, donor rim cultures, donor mate outcomes, clinical course, diagnostic tests, and clinical outcome. RESULTS: A DMEK patient developed a single infiltrate approximately 1 month after uncomplicated DMEK...
December 2017: Cornea
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