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https://www.readbyqxmd.com/read/28801473/type-2-diabetes-in-the-real-world-the-elusive-nature-of-glycemic-control
#1
Steven V Edelman, William H Polonsky
Despite U.S. Food and Drug Administration (FDA) approval of over 40 new treatment options for type 2 diabetes since 2005, the latest data from the National Health and Nutrition Examination Survey show that the proportion of patients achieving glycated hemoglobin (HbA1c) <7.0% (<53 mmol/mol) remains around 50%, with a negligible decline between the periods 2003-2006 and 2011-2014. The Healthcare Effectiveness Data and Information Set reports even more alarming rates, with only about 40% and 30% of patients achieving HbA1c <7...
August 11, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28792819/clinical-negligence-litigation-balancing-the-interests
#2
John Tingle
John Tingle, Reader in Health Law at Nottingham Trent University, discusses a recent report by the Medical Protection Society on the need to control the costs of clinical negligence litigation.
August 10, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28780202/tailor-made-ge-doped-silica-glass-for-clinical-diagnostic-x-ray-dosimetry
#3
Amjad Alyahyawi, T Jupp, M Alkhorayef, D A Bradley
In the modern clinical practice of diagnostic radiology there is a growing demand for radiation dosimetry, it also being recognized that with increasing use of X-ray examinations additional population dose will result, accompanied by an additional albeit low potential for genetic consequences. At the doses typical of diagnostic radiology there is also a low statistical risk for cancer induction; in adhering to best practice, to be also implied is a low but non-negligible potential for deterministic sensitive organ responses, including in regard to the skin and eyes...
July 22, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28764713/non-iterative-geometric-approach-for-inverse-kinematics-of-redundant-lead-module-in-a-radiosurgical-snake-like-robot
#4
Olatunji Mumini Omisore, Shipeng Han, Lingxue Ren, Nannan Zhang, Kamen Ivanov, Ahmed Elazab, Lei Wang
BACKGROUND: Snake-like robot is an emerging form of serial-link manipulator with the morphologic design of biological snakes. The redundant robot can be used to assist medical experts in accessing internal organs with minimal or no invasion. Several snake-like robotic designs have been proposed for minimal invasive surgery, however, the few that were developed are yet to be fully explored for clinical procedures. This is due to lack of capability for full-fledged spatial navigation. In rare cases where such snake-like designs are spatially flexible, there exists no inverse kinematics (IK) solution with both precise control and fast response...
August 1, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28731391/malpractice-litigation-following-spine-surgery
#5
Alan H Daniels, Roy Ruttiman, Adam E M Eltorai, J Mason DePasse, Bielinsky A Brea, Mark A Palumbo
OBJECTIVE Adverse events related to spine surgery sometimes lead to litigation. Few studies have evaluated the association between spine surgical complications and medical malpractice proceedings, outcomes, and awards. The aim of this study was to identify the most frequent causes of alleged malpractice in spine surgery and to gain insight into patient demographic and clinical characteristics associated with medical negligence litigation. METHODS A search for "spine surgery" spanning February 1988 to May 2015 was conducted utilizing the medicolegal research service VerdictSearch (ALM Media Properties, LLC)...
July 21, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28720558/my-team-of-care-study-a-pilot-randomized-controlled-trial-of-a-web-based-communication-tool-for-collaborative-care-in-patients-with-advanced-cancer
#6
Teja Voruganti, Eva Grunfeld, Trevor Jamieson, Allison M Kurahashi, Bhadra Lokuge, Monika K Krzyzanowska, Muhammad Mamdani, Rahim Moineddin, Amna Husain
BACKGROUND: The management of patients with complex care needs requires the expertise of health care providers from multiple settings and specialties. As such, there is a need for cross-setting, cross-disciplinary solutions that address deficits in communication and continuity of care. We have developed a Web-based tool for clinical collaboration, called Loop, which assembles the patient and care team in a virtual space for the purpose of facilitating communication around care management...
July 18, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28718236/dose-comparison-and-side-effect-profile-of-metformin-extended-release-versus-metformin-immediate-release
#7
Maliha Hameed, Khurshid Khan, Sadia Salman, Nasir Mehmood
BACKGROUND: Diabetes Mellitus type 2 is very common worldwide, with majority of cases in Asia Pacific region. Metformin is the first line therapy, along with lifestyle modification for all type 2 diabetics as recommended by ADA. Metformin is available as conventional Metformin Immediate Release (MIR) and Metformin Extended Release (MXR). Metformin XR has better gastrointestinal tolerability and fewer side effects as compared to Metformin IR, with similar efficacy regarding anti-hyperglycaemic effects...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28692857/modelling-and-extraction-of-pulsatile-radial-distension-and-compression-motion-for-automatic-vessel-segmentation-from-video
#8
Alborz Amir-Khalili, Ghassan Hamarneh, Rafeef Abugharbieh
Identification of vascular structures from medical images is integral to many clinical procedures. Most vessel segmentation techniques ignore the characteristic pulsatile motion of vessels in their formulation. In a recent effort to automatically segment vessels that are hidden under fat, we motivated the use of the magnitude of local pulsatile motion extracted from surgical endoscopic video. In this article we propose a new approach that leverages the local orientation, in addition to magnitude of motion, and demonstrate that the extended computation and utilization of motion vectors can improve the segmentation of vascular structures...
June 29, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28685035/initiating-a-participatory-action-research-process-in-the-agincourt-health-and-socio-demographic-surveillance-site
#9
Oghenebrume Wariri, Lucia D'Ambruoso, Rhian Twine, Sizzy Ngobeni, Maria van der Merwe, Barry Spies, Kathleen Kahn, Stephen Tollman, Ryan G Wagner, Peter Byass
BACKGROUND: Despite progressive health policy, disease burdens in South Africa remain patterned by deeply entrenched social inequalities. Accounting for the relationships between context, health and risk can provide important information for equitable service delivery. The aims of the research were to initiate a participatory research process with communities in a low income setting and produce evidence of practical relevance. METHODS: We initiated a participatory action research (PAR) process in the Agincourt health and socio-demographic surveillance site (HDSS) in rural north-east South Africa...
June 2017: Journal of Global Health
https://www.readbyqxmd.com/read/28666044/electronic-health-record-implementation-is-associated-with-a-negligible-change-in-outpatient-volume-and-billing
#10
Matthew L Webb, Daniel D Bohl, Jennifer M Fischer, Andre M Samuel, Adam M Lukasiewicz, Bryce A Basques, Jonathan N Grauer
The Health Information Technology for Economic and Clinical Health (HITECH) Act mandated that hospitals begin using electronic health records (EHRs). To investigate potential up-coding, we reviewed billing data for changes in patient volumes and up-coding around the time of EHR implementation at our academic medical center. We identified all new, consultation, and return outpatient visits on a monthly basis in the general internal medicine and orthopedics departments at our center. We compared the volume of patient visits and the level of billing coding in these 2 departments before and after their transitions to ambulatory EHRs...
May 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28601118/determination-of-red-blood-cells-in-urinary-sediment-do-ph-and-specific-gravity-of-urine-matter
#11
Nuša Avguštin, Alexander Jerman, Žiga Rotar, Špela Borštnar, Andrej Škoberne, Jelka Lindič
INTRODUCTION: It has been postulated that erythrocyte cell lysis in urine is common in the case of low urine specific gravity and high urine pH. We aimed to verify the influence of urine dipstick pH and specific gravity on erythrocyturia in the urine sediment in the case of positive dipstick hemoglobinuria. METHODS: We retrospectively collected data on dipstick specific gravity, pH, and urine sediment analysis done by nephrologists in the clinical and research urine laboratory at the Department of Nephrology, University Medical Center Ljubljana...
June 9, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28593789/prevalence-and-outcome-of-patients-with-cancer-and-acute-coronary-syndrome-undergoing-percutaneous-coronary-intervention-a-bleemacs-substudy
#12
Mario Iannaccone, Fabrizio D'Ascenzo, Paolo Vadalà, Stephen B Wilton, Patrizia Noussan, Francesco Colombo, Sergio Raposeiras Roubín, Emad Abu Assi, José Ramón González-Juanatey, Jose Paulo Simao Henriques, Jorge Saucedo, Wouter J Kikkert, Iván Nuñez-Gil, Albert Ariza-Sole, Xian-Tao Song, Dimitrios Alexopoulos, Christoph Liebetrau, Tetsuma Kawaji, Claudio Moretti, Roberto Garbo, Zenon Huczek, Shao-Ping Nie, Toshiharu Fujii, Luis Cl Correia, Masa-Aki Kawashiri, José María García Acuña, Danielle Southern, Emilio Alfonso, Belén Terol, Alberto Garay, Dongfeng Zhang, Yalei Chen, Ioanna Xanthopoulou, Neriman Osman, Helge Möllmann, Hiroki Shiomi, Francesca Giordana, Michal Kowara, Krzysztof Filipiak, Xiao Wang, Yan Yan, Jing-Yao Fan, Yuji Ikari, Takuya Nakahashi, Kenji Sakata, Fiorenzo Gaita, Masakazu Yamagishi, Oliver Kalpak, Sasko Kedev
BACKGROUND: The prevalence and outcome of patients with cancer that experience acute coronary syndrome (ACS) have to be determined. METHODS AND RESULTS: The BleeMACS project is a multicentre observational registry enrolling patients with acute coronary syndrome undergoing percutaneous coronary intervention worldwide in 15 hospitals. The primary endpoint was a composite event of death and re-infarction after one year of follow-up. Bleedings were the secondary endpoint...
June 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28584209/analysis-of-closed-claims-in-the-clinical-management-of-rheumatoid-arthritis-in-japan
#13
Yasuhiro Otaki, Makiko DaSilva Ishida, Yuichi Saito, Yasuaki Oyama, Giichiro Oiso, Mitsuru Moriyama
BACKGROUND: Despite an increasing awareness of the risk of medical errors, few data sources are available to highlight the characteristics and patterns of medical errors in the clinical management of rheumatoid arthritis (RA). The present study aimed to evaluate medical malpractice claims associated with the management of RA and other autoimmune connective tissue diseases (ACTDs). METHODS: We analyzed 38 ACTD-associated closed claims extracted from a total of 8530 claims processed between July 2004 and June 2014 by the Tokyo headquarters office of Sompo Japan Nipponkoa Incorporated, a leading malpractice insurer in Japan...
June 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28572883/impact-of-creatinine-methodology-on-glomerular-filtration-rate-estimation-in-diabetes
#14
Marijana Vučić Lovrenčić, Vanja Radišić Biljak, Kristina Blaslov, Sandra Božičević, Lea Smirčić Duvnjak
AIM: To evaluate the influence of creatinine methodology on the performance of chronic kidney disease (CKD)-Epidemiology Collaboration Group-calculated estimated glomerular filtration rate (CKD-EPI-eGFR) for CKD diagnosis/staging in a large cohort of diabetic patients. METHODS: Fasting blood samples were taken from diabetic patients attending our clinic for their regular annual examination, including laboratory measurement of serum creatinine and eGFR. RESULTS: Our results indicated an overall excellent agreement in CKD staging (kappa = 0...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28528589/traumatic-brain-injury-in-the-workplace
#15
Michael Paci, Claire Infante-Rivard, Judith Marcoux
OBJECTIVES: Work-related traumatic brain injuries (TBIs) are not well documented in the literature. Published studies mostly rely on worker databases that fail to provide clinically relevant information. Our objective is to describe the characteristics of hospitalized patients and their work-related TBI. METHODS: We used the Québec provincial trauma and TBI program databases to identify all patients with a diagnosis of work-related TBI admitted to the Montreal General Hospital, a level 1 trauma center, between 2000 and 2014...
May 22, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28506388/discordant-response-of-low-density-lipoprotein-cholesterol-and-lipoprotein-a-levels-to-monoclonal-antibodies-targeting-proprotein-convertase-subtilisin-kexin-type-9
#16
Jonathan B Edmiston, Nathan Brooks, Hagai Tavori, Jessica Minnier, Bart Duell, Jonathan Q Purnell, Tina Kaufman, Cezary Wojcik, Szilard Voros, Sergio Fazio, Michael D Shapiro
BACKGROUND: Clinical trials testing proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) have demonstrated an unanticipated but significant lipoprotein (a) (Lp(a))-lowering effect, on the order of 25% to 30%. Although the 50% to 60% reduction in low-density lipoprotein (LDL)-cholesterol (LDL-C) achieved by PCSK9i is mediated through its effect on LDL receptor (LDLR) preservation, the mechanism for Lp(a) lowering is unknown. OBJECTIVE: We sought to characterize the degree of concordance between LDL-C and Lp(a) lowering because of PCSK9i in a standard of care patient cohort...
May 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28496225/altmetric-analysis-of-2015-dental-literature-a-cross-sectional-survey
#17
J Kolahi, P Iranmanesh, S Khazaei
Introduction To report and analyse Altmetric data of all dental articles and journals in 2015.Methods To identify all 2015 dental articles, PubMed was searched via Altmetric platform using the following query: ("2015/1/1"[PDAT]: "2015/12/31"[PDAT]) AND jsubsetd[text] NOT 2016[PDAT] on November 12, 2016. Altmetric data of all 2015 dental articles and journals were extracted and analysed by Microsoft Office Excel 2016 using descriptive statistics, graphs and trend-line analysis. To find the most important and influential Altmetric factors, multi-layered perceptron artificial neural network was employed using SPSS 22...
May 12, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28479642/does-medical-malpractice-law-improve-health-care-quality
#18
Michael Frakes, Anupam B Jena
We assess the potential for medical liability forces to deter medical errors and improve health care treatment quality, identifying liability's influence by drawing on variations in the manner by which states formulate the negligence standard facing physicians. Using hospital discharge records from the National Hospital Discharge Survey and clinically-validated quality metrics inspired by the Agency for Health Care Research and Quality, we find evidence suggesting that treatment quality may improve upon reforms that expect physicians to adhere to higher quality clinical standards...
November 2016: Journal of Public Economics
https://www.readbyqxmd.com/read/28463662/antibiotic-susceptibility-of-planktonic-and-biofilm-grown-staphylococci-isolated-from-implant-associated-infections-should-mbec-and-nature-of-biofilm-formation-replace-mic
#19
Aaron J Brady, Garry Laverty, Deirdre F Gilpin, Patricia Kearney, Michael Tunney
PURPOSE: The purpose of this study was to develop an alternative, more clinically relevant approach to susceptibility reporting for implant-associated infections. Using 20 staphylococcal isolates, isolated from clinical implant infections, the majority (85 %) demonstrated biofilm-forming capabilities. A significantly increased minimum biofilm eradication concentration (MBEC) compared to minimum inhibitory concentration (MIC) breakpoint was obtained, with MBEC values greater than 256 µg ml-1 for the majority of bacteria...
April 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28454652/selection-characterization-and-application-of-dna-aptamers-for-detection-of-mycobacterium-tuberculosis-secreted-protein-mpt64
#20
Marzhan Sypabekova, Aliya Bekmurzayeva, Ronghui Wang, Yanbin Li, Claude Nogues, Damira Kanayeva
Rapid detection of Mycobacterium tuberculosis (Mtb), an etiological agent of tuberculosis (TB), is important for global control of this disease. Aptamers have emerged as a potential rival for antibodies in therapeutics, diagnostics and biosensing due to their inherent characteristics. The aim of the current study was to select and characterize single-stranded DNA aptamers against MPT64 protein, one of the predominant secreted proteins of Mtb pathogen. Aptamers specific to MPT64 protein were selected in vitro using systematic evolution of ligands through exponential enrichment (SELEX) method...
May 2017: Tuberculosis
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