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spasmodic dysphonia

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https://www.readbyqxmd.com/read/27866691/vocal-parameters-and-self-perception-in-individuals-with-adductor-spasmodic-dysphonia
#1
Gleidy Vannesa E Rojas, Hilton Ricz, Vitor Tumas, Guilherme R Rodrigues, Patrícia Toscano, Lílian Aguiar-Ricz
OBJECTIVE: The study aimed to compare and correlate perceptual-auditory analysis of vocal parameters and self-perception in individuals with adductor spasmodic dysphonia before and after the application of botulinum toxin. STUDY DESIGN: This is a prospective cohort study. METHODS: Sixteen individuals with a diagnosis of adductor spasmodic dysphonia were submitted to the application of botulinum toxin in the thyroarytenoid muscle, to the recording of a voice signal, and to the Voice Handicap Index (VHI) questionnaire before the application and at two time points after application...
November 17, 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/27836428/high-speed-imaging-of-vocal-fold-vibration-onset-delay-normal-versus-abnormal
#2
Peak Woo
OBJECTIVES: Vocal fold vibration onset delay (VFVOD) is heard frequently in spasmodic dysphonia and in muscle tension dysphonia. VFVOD changes due to other vocal pathologies have not been investigated. VFVOD during sustained vowel production was estimated with high-speed video in 10 normal and 40 pathologic subjects (scars, vocal fold paralysis, vocal fold nodules, and polyps). Analysis of high-speed video was done using digital kymography. RESULTS: VFVOD can be divided into two portions...
November 8, 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/27808415/an-open-label-study-of-sodium-oxybate-in-spasmodic-dysphonia
#3
Anna F Rumbach, Andrew Blitzer, Steven J Frucht, Kristina Simonyan
OBJECTIVES/HYPOTHESIS: Spasmodic dysphonia (SD) is a task-specific laryngeal dystonia that affects speech production. Co-occurring voice tremor (VT) often complicates the diagnosis and clinical management of SD. Treatment of SD and VT is largely limited to botulinum toxin injections into laryngeal musculature; other pharmacological options are not sufficiently developed. STUDY DESIGN: Open-label study. METHODS: We conducted an open-label study in 23 SD and 22 SD/VT patients to examine the effects of sodium oxybate (Xyrem), an oral agent with therapeutic effects similar to those of alcohol in these patients...
November 3, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27803079/effect-of-botulinum-toxin-and-surgery-among-spasmodic-dysphonia-patients-a-systematic-review
#4
Babette F van Esch, Inge Wegner, Inge Stegeman, Wilko Grolman
OBJECTIVE: The effect of botulinum toxin among patients with adductor spasmodic dysphonia (AdSD) is temporary. To optimize long-term treatment outcome, other therapy options should be evaluated. Alternative treatment options for AdSD comprise several surgical treatments, such as thyroarytenoid myotomy, thyroplasty, selective laryngeal adductor denervation-reinnervation, laryngeal nerve crush, and recurrent laryngeal nerve resection. Here, we present the first systematic review comparing the effect of botulinum toxin with surgical treatment among patients diagnosed with AdSD...
November 1, 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27746043/brain-activity-in-patients-with-adductor-spasmodic-dysphonia-detected-by-functional-magnetic-resonance-imaging
#5
Asanori Kiyuna, Norimoto Kise, Munehisa Hiratsuka, Shunsuke Kondo, Takayuki Uehara, Hiroyuki Maeda, Akira Ganaha, Mikio Suzuki
OBJECTIVES: Spasmodic dysphonia (SD) is considered a focal dystonia. However, the detailed pathophysiology of SD remains unclear, despite the detection of abnormal activity in several brain regions. The aim of this study was to clarify the pathophysiological background of SD. STUDY DESIGN: This is a case-control study. METHODS: Both task-related brain activity measured by functional magnetic resonance imaging by reading the five-digit numbers and resting-state functional connectivity (FC) measured by 150 T2-weighted echo planar images acquired without any task were investigated in 12 patients with adductor SD and in 16 healthy controls...
October 13, 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/27647704/epidemiological-clinical-and-genetic-aspects-of-adult-onset-isolated-focal-dystonia-in-ireland
#6
L Williams, E McGovern, O Kimmich, A Molloy, I Beiser, J S Butler, F Molloy, P Logan, D G Healy, T Lynch, R Walsh, L Cassidy, P Moriarty, H Moore, T McSwiney, C Walsh, S O'Riordan, M Hutchinson
BACKGROUND: Adult onset idiopathic isolated focal dystonia presents with a number of phenotypes. Reported prevalence rates vary considerably; well-characterized cohorts are important to our understanding of this disorder. AIM: To perform a nationwide epidemiological study of adult onset idiopathic isolated focal dystonia in the Republic of Ireland. METHODS: Patients with adult onset idiopathic isolated focal dystonia were recruited from multiple sources...
September 19, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27633917/gender-differences-in-onabotulinum-toxin-a-dosing-for-adductor-spasmodic-dysphonia
#7
Michael Z Lerner, Benjamin A Lerner, Amit A Patel, Andrew Blitzer
OBJECTIVES/HYPOTHESIS: The objective of this study was to determine the influence of gender on onabotulinum toxin A dosing for the treatment of adductor spasmodic dysphonia symptoms. STUDY DESIGN: Retrospective review. METHODS: A chart review of the senior author's database of botulinum toxin injections was performed. Patients diagnosed with adductor spasmodic dysphonia who received onabotulinum toxin A (BoNTA) injections to the thyroarytenoid muscle for at least 5 years were included for study...
September 16, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27620668/morell-mackenzie-s-contribution-to-the-description-of-spasmodic-dysphonia
#8
Marjorie Perlman Lorch, Renata Whurr
OBJECTIVES: Since the middle of the 20th century, most discussions of spasmodic dysphonia (SD) reference a paper by Ludwig Traube published in1871 as the first historical citation, crediting him with priority for this clinical syndrome. However, our recent research has determined that the original observation by Traube was published in 1864 and does not in fact describe what is currently recognized as SD. It appears that many clinics throughout Europe and North America were investigating and publishing observations on a range of voice disorders...
September 12, 2016: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27617622/clinical-characteristics-of-voice-speech-and-swallowing-disorders-in-oromandibular-dystonia
#9
Alexandre Kreisler, Anne-Caroline Verpraet, Solène Veit, Odile Pennel-Ployart, Hélène Béhal, Alain Duhamel, Alain Destée
Purpose: To better define the clinical characteristics of idiopathic oromandibular dystonia, we studied voice, speech, and swallowing disorders and their impact on activities of daily living. Method: Fourteen consecutive patients with idiopathic oromandibular dystonia and 14 matched, healthy control subjects were included in the study. Results: Dysarthria was the most common disorder and its characteristics varied from one patient to another...
September 8, 2016: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/27520509/liquid-type-botulinum-toxin-type-a-in-adductor-spasmodic-dysphonia-a-prospective-pilot-study
#10
Wonjae Cha, Jeon Yeob Jang, Soo-Geun Wang, Ji-Heon Kang, Min-Gyu Jo
OBJECTIVES: Botulinum toxin (BTX) has been widely used to treat adductor spasmodic dysphonia (ADSD). Most commercially available forms of BTX require reconstitution before use, which may increase the risk of contamination and requires careful titration. Recently, a liquid-type BTX type A (BTX-A) has been developed, which should simplify the procedure and enhance its efficacy. Herein, we present a prospective pilot study to investigate the efficacy and safety of liquid-type BTX-A in the treatment of ADSD...
August 9, 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/27382680/-a-study-on-vowel-duration-and-word-length-of-adductor-spasmodic-dysphonia
#11
Zhipeng Chen, Pingjiang Ge
OBJECTIVE: To understand the vowel duration and statement reading of the adductor spasmodic dysphonia (ADSD) patients compared with their normal controls, and provide ideas for clinical diagnosis and treatment. METHOD: Twenty-nine ADSD patients were included in the research, with 31 normal controls. All subjects filled in form voice handicap index (VHI) by themselves. Maximum phonetic time (MPT) and maximum loudness phonetic time(MLPT) were tested on /a/ sound for all patients...
March 2016: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/27346568/cortical-sensorimotor-alterations-classify-clinical-phenotype-and-putative-genotype-of-spasmodic-dysphonia
#12
G Battistella, S Fuertinger, L Fleysher, L J Ozelius, K Simonyan
BACKGROUND AND PURPOSE: Spasmodic dysphonia (SD), or laryngeal dystonia, is a task-specific isolated focal dystonia of unknown causes and pathophysiology. Although functional and structural abnormalities have been described in this disorder, the influence of its different clinical phenotypes and genotypes remains scant, making it difficult to explain SD pathophysiology and to identify potential biomarkers. METHODS: We used a combination of independent component analysis and linear discriminant analysis of resting-state functional magnetic resonance imaging data to investigate brain organization in different SD phenotypes (abductor versus adductor type) and putative genotypes (familial versus sporadic cases) and to characterize neural markers for genotype/phenotype categorization...
October 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27262220/laryngeal-myofascial-pain-syndrome-as-a-new-diagnostic-entity-of-dysphonia
#13
Soo Yeon Jung, Hae Sang Park, Hasuk Bae, Jeong Hyun Yoo, Hyung Jun Park, Kee Duk Park, Han Su Kim, Sung Min Chung
OBJECTIVE: To consider the feasibility of diagnosing intrinsic laryngeal muscle myofascial pain syndrome (MPS) in dysphonic patients who demonstrated immediate symptom and stroboscopic finding improvement after laryngeal electromyography (LEMG) without further treatment. METHODS: A chart review of patients who showed subtle vocal fold movement abnormalities on a stroboscopic examination and underwent ultrasonography (US)-guided LEMG was performed. Patients with vocal fold paralysis, mucosal lesions, spasmodic dysphonia, and vocal tremor on stroboscopic examination were excluded...
June 1, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27257292/lateral-cricoarytenoid-release-development-of-a-novel-surgical-treatment-option-for-adductor-spasmodic-dysphonia-in-a-canine-laryngeal-model
#14
Andrea M Park, Randal C Paniello
OBJECTIVE: To investigate the efficacy of a novel adductor muscle-releasing technique designed to decrease the force of vocal fold adduction, as a potential surgical therapy for patients with adductor spasmodic dysphonia (ADSD). STUDY DESIGN: Experimental animal study. METHODS: A canine laryngeal model was used to assess the acute and sustained efficacy of a lateral cricoarytenoid (LCA) muscle release. A total of 34 canine hemilaryngeal preparations were divided among 7 experimental groups...
September 2016: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27223665/evaluation-of-type-ii-thyroplasty-on-phonatory-physiology-in-an-excised-canine-larynx-model
#15
Erin E Devine, Matthew R Hoffman, Timothy M McCulloch, Jack J Jiang
OBJECTIVES/HYPOTHESIS: Type II thyroplasty is an alternative treatment for spasmodic dysphonia, addressing hyperadduction by incising and lateralizing the thyroid cartilage. We quantified the effect of lateralization width on phonatory physiology using excised canine larynges. METHODS: Normal closure, hyperadduction, and type II thyroplasty (lateralized up to 5 mm at 1-mm increments with hyperadducted arytenoids) were simulated in excised larynges (N = 7). Aerodynamic, acoustic, and videokymographic data were recorded at three subglottal pressures relative to phonation threshold pressure (PTP)...
May 25, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27188707/dystonia-causing-mutations-as-a-contribution-to-the-etiology-of-spasmodic-dysphonia
#16
Claudio M de Gusmão, Tania Fuchs, Andrew Moses, Trisha Multhaupt-Buell, Phillip C Song, Laurie J Ozelius, Ramon A Franco, Nutan Sharma
OBJECTIVE: Spasmodic dysphonia is a focal dystonia of the larynx with heterogeneous manifestations and association with familial risk factors. There are scarce data to allow precise understanding of etiology and pathophysiology. Screening for dystonia-causing genetic mutations has the potential to allow accurate diagnosis, inform about genotype-phenotype correlations, and allow a better understanding of mechanisms of disease. STUDY DESIGN: Cross-sectional study...
October 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27171035/thalamic-volume-is-reduced-in-cervical-and-laryngeal-dystonias
#17
Jeff L Waugh, John K Kuster, Jacob M Levenstein, Nikos Makris, Trisha J Multhaupt-Buell, Lewis R Sudarsky, Hans C Breiter, Nutan Sharma, Anne J Blood
BACKGROUND: Dystonia, a debilitating movement disorder characterized by abnormal fixed positions and/or twisting postures, is associated with dysfunction of motor control networks. While gross brain lesions can produce secondary dystonias, advanced neuroimaging techniques have been required to identify network abnormalities in primary dystonias. Prior neuroimaging studies have provided valuable insights into the pathophysiology of dystonia, but few directly assessed the gross volume of motor control regions, and to our knowledge, none identified abnormalities common to multiple types of idiopathic focal dystonia...
2016: PloS One
https://www.readbyqxmd.com/read/27143711/botulinum-toxin-in-secondarily-nonresponsive-patients-with-spasmodic-dysphonia
#18
Niv Mor, Christopher Tang, Andrew Blitzer
Chemodenervation with botulinum toxin (BoNT) has been effective and well tolerated for all types of dystonia for >30 years. We reviewed outcomes of our patients treated with BoNT serotype A (BoNT-A) for spasmodic dysphonia (SD) who became secondarily nonresponsive. We found that 8 of 1400 patients became nonresponsive to BoNT-A (0.57%), which is lower than the secondary nonresponse rate in other dystonias. After a cessation period, 4 of our patients resumed BoNT-A injections, and recurrence of immunoresistance was not seen in any of them...
September 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27117902/tracing-spasmodic-dysphonia-the-source-of-ludwig-traube-s-priority
#19
Marjorie Perlman Lorch, Renata Whurr
OBJECTIVES: Since the mid-20th century, one citation is given historical priority as the first description of spasmodic dysphonia (SD): Ludwig Traube's 1871 case of the "spastic form of nervous hoarseness." Our objective is to understand how this case serves as the foundation of understanding laryngeal movement disorders. METHODS: The original German paper was located and translated. Bibliographical and bibliometric methods are used to determine the citation history of this original source over the past 140 years...
August 2016: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27107402/minithyrotomy-with-radiofrequency-induced-thermotherapy-for-the-treatment-of-adductor-spasmodic-dysphonia
#20
Shaun C Desai, Andrea M Park, Rebecca D Chernock, Randal C Paniello
OBJECTIVES/HYPOTHESIS: A simple, safe and effective surgical alternative for treating adductor spasmodic dysphonia (ADSD) would appeal to many patients. This study evaluates a new option, using radiofrequency-induced thermotherapy (RFITT) of the thyroarytenoid muscle (TA) via the minithyrotomy approach to reduce the force of adduction. METHODS: Fifteen dogs were used. In part 1, the optimal RFITT power settings, exposure time, probe location, and number of passes were determined...
October 2016: Laryngoscope
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