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https://www.readbyqxmd.com/read/28534047/polysomnographic-heart-rate-variability-indices-and-atrial-ectopy-associated-with-incident-atrial-fibrillation-risk-in-older-community-dwelling-men
#1
Dileep Raman, Farhad Kaffashi, Li-Yung Lui, William H Sauer, Susan Redline, Peter Stone, Peggy M Cawthon, Katie L Stone, Kristine E Ensrud, Sonia Ancoli-Israel, Kenneth Loparo, Reena Mehra
BACKGROUND: Autonomic dysfunction contributes to atrial fibrillation (AF). OBJECTIVE: We hypothesized that polysomnogram (PSG)-based heart rate variability (HRV) autonomic function biomarkers are associated with incident AF and these associations are modified by measures of sleep disordered breathing (SDB). METHODS: 2350 participants of a multi-center prospective study (Outcomes of Sleep Disorders in Older Men Study) without baseline AF underwent sleep studies with incident adjudicated AF follow up (8...
May 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/28507568/effect-of-ramipril-hydrochlorothiazide-and-ramipril-canrenone-combination-on-atrial-fibrillation-recurrence-in-hypertensive-type-2-diabetic-patients-with-and-without-cardiac-autonomic-neuropathy
#2
Daniele Bosone, Alfredo Costa, Natascia Ghiotto, Matteo Cotta Ramusino, Annalisa Zoppi, Angela D'Angelo, Roberto Fogari
INTRODUCTION: The aim of this study was to compare the effect of ramipril/canrenone versus ramipril/hydrochlorothiazide (HCTZ) combination on atrial fibrillation (AF) recurrence in type 2 diabetic hypertensives with and without cardiac autonomic neuropathy (CAN). MATERIAL AND METHODS: A total of 289 hypertensive type 2 diabetic patients, 95 with CAN, in sinus rhythm but with at least two episodes of AF in the previous 6 months were randomized to ramipril 5 mg plus canrenone 50 mg (titrated to 10/100 mg) or to ramipril 5 mg plus HCTZ 12...
April 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28497765/-acute-myocardial-infarction-among-icelanders-forty-years-old-and-younger-2005-2009-comparison-with-a-study-carried-out-1980-1984
#3
Bjorn Jakob Magnusson, Uggi Agnarsson, Thorarinn Guðnason, Gudmundur Þorgeirsson
INTRODUCTION: While acute myocardial infarction  (AMI) mostly is a disease of the elderly it also affects younger individuals, often with serious consequenses. In 1980-1984 a study was carried out on the incidence, risk factors, infarct location and distribution of atherosclerosis among Icelanders forty years and younger with AMI. Here we present the results of a similar study carried out for the five year period 2005-2009. MATERIALS AND METHODS: Medical and autopsy records of all individuals, forty years and younger, diagnosed with AMI (I21 in ICD-10) at Landspitali, National University Hospital 2005-2009, or suffering sudden cardiac death in Iceland during the same period were reviewed...
January 2017: Læknablađiđ
https://www.readbyqxmd.com/read/28486916/are-markers-of-cardiac-dysfunction-useful-in-the-assessment-of-cardiovascular-risk-in-dialysis-patients
#4
Beata Franczyk, Anna Gluba-Brzózka, Piotr Bartnicki, Maciej Banach, Jacek Rysz
Cardiovascular morbidity and mortality of dialysis patients is a major problem in this group. The purpose of this study was also to evaluate whether any of studied markers are better than troponin in early detection of the occurrence of ventricular arrhythmias and prolongation of QT interval. This study included 45 patients undergoing haemodialysis. ECG Holter and echocardiographic examination were performed before and after dialysis. The concentration of markers: copeptin, GDF-15, HFABP and troponin were measured with the use of ELISA tests...
May 8, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28456833/relationship-between-fragmented-qrs-complexes-and-cardiac-status-in-duchenne-muscular-dystrophy-multimodal-validation-using-echocardiography-magnetic-resonance-imaging-and-holter-monitoring
#5
Min-Jung Cho, Ji-Won Lee, JeSang Lee, Yong Bum Shin, Hyoung Doo Lee
The presence of fragmented QRS is a known marker of heterogeneous ventricular activation around the myocardial scar area. We validated whether fragmented QRS shows any association with ventricular dysfunction, fibrosis, or ventricular arrhythmias in patients with Duchenne muscular dystrophy (DMD). Thirty-seven patients with DMD were evaluated using electrocardiography (ECG), echocardiography, cardiac magnetic resonance, and 24-h Holter monitoring. Associations between fragmented QRS and ventricular dysfunction, fibrosis, or ventricular arrhythmia were investigated...
April 29, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28453471/a-randomized-double-blind-placebo-controlled-phase-ii-study-of-oral-elnd005-scyllo-inositol-in-young-adults-with-down-syndrome-without-dementia
#6
Michael S Rafii, Brian G Skotko, Mary Ellen McDonough, Margaret Pulsifer, Casey Evans, Eric Doran, Gabriela Muranevici, Patrick Kesslak, Susan Abushakra, Ira T Lott
BACKGROUND: ELND005 (scyllo-Inositol; cyclohexane-1,2,3,4,5,6-hexol) has been evaluated as a potential disease-modifying treatment for Alzheimer's disease (AD). Individuals with Down syndrome (DS) have an increased risk for developing AD dementia. OBJECTIVE: To evaluate the safety and tolerability of ELND005 and to determine its pharmacokinetics (PK) and relationship between PK parameters, safety outcome measures, and exploratory efficacy outcome measures in young adults with DS without dementia...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28398490/the-prognostic-benefit-of-cardiac-resynchronization-therapy-is-greater-in-concordant-vs-discordant-left-bundle-branch-block-in-the-multicenter-automatic-defibrillator-implantation-trial-cardiac-resynchronization-therapy-madit-crt
#7
Luigi Padeletti, Alberto Aimo, Bella Vishenvsky, Arielle Schwartz, Scott McNitt, Paul J Wang, Arthur J Moss, Michele Emdin, Wojciech Zareba
Aims: Discordant and concordant left bundle branch block (dLBBB/cLBBB) are characterized by negative or positive T waves, respectively, in lateral leads. We assessed if the two morphologies are associated with different clinical status and prognosis in patients with heart failure (HF) and current indication to Cardiac Resynchronization Therapy (CRT)/CRT-Defibrillator (CRT-D). Methods and results: Baseline electrocardiograms of 1270 patients with LBBB in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy cohort were analysed to identify dLBBB and cLBBB...
April 7, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28394409/evaluation-of-qtc-in-rett-syndrome-correlation-with-age-severity-and-genotype
#8
Jane Crosson, Siddharth Srivastava, Genila M Bibat, Siddharth Gupta, Aditi Kantipuly, Constance Smith-Hicks, Scott M Myers, Abanti Sanyal, Gayane Yenokyan, Joel Brenner, Sakkubai R Naidu
Rett syndrome (RTT) is caused by MECP2 mutations, resulting in various neurological symptoms. Prolonged corrected QT interval (QTc) is also reported and is a speculated cause of sudden death in RTT. The purpose of this study was to correlate QTc in RTT patients with age, clinical severity, and genotype. 100 RTT patients (98 females, 2 males) with MECP2 mutations underwent baseline neurological evaluation (KKI-RTT Severity Scale) and QTc measurement (standard 12 lead electrocardiogram) as part of our prospective natural history study...
April 10, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28393707/relationship-of-high-sensitivity-c-reactive-protein-concentrations-and-systolic-heart-failure
#9
Sheng Kang, Lie-Ying Fan, Ming Chen, Jue Li, Zhong-Min Liu
Objective Excessive activated proinflammatory cytokines may promote extracellular matrix alterations which induce adverse left ventricular remodeling in systolic heart failure (SHF). We sought to identify whether high-sensitivity C-reactive protein (hsCRP) levels were independently associated with SHF. Methods In our retrospective case-control study, 2236 subjects were included, and 260 patients had SHF. Blood sample collection, clinical laboratory tests, electrocardiogram and echocardiography examinations were performed...
April 4, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28390723/manipulation-of-reproductive-seasonality-using-melatonin-implantation-in-anglo-nubian-does-treated-with-controlled-internal-drug-release-and-equine-chorionic-gonadotropin-during-the-nonbreeding-season
#10
M Y El-Mokadem, A N M Nour El-Din, T A Ramadan, A M A Rashad, T A Taha, M A Samak
The objective of this study was to compare the efficiency of hormonal treatments on ovarian activity and reproductive performance in anestrous Anglo-Nubian does during the nonbreeding season (February to May). A total of 48 multiparous does were divided into 2 groups (24 lactating does and 24 dry does). In each group, animals were allocated randomly into 2 equal subgroups (12 does each). In the first subgroup, does received a single 18-mg melatonin implant for 42 d followed by a controlled internal drug release (CIDR) device for 19 d in conjunction with 500 IU of equine chorionic gonadotropin (eCG) i...
April 5, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28356306/effect-of-age-and-sex-on-the-qtc-interval-in-children-and-adolescents-with-type-1-and-2-long-qt-syndrome
#11
Arja S Vink, Sally-Ann B Clur, Ronald B Geskus, Andreas C Blank, Charlotte C A De Kezel, Masao Yoshinaga, Nynke Hofman, Arthur A M Wilde, Nico A Blom
BACKGROUND: In congenital long-QT syndrome, age, sex, and genotype have been associated with cardiac events, but their effect on the trend in QTc interval has never been established. We, therefore, aimed to assess the effect of age and sex on the QTc interval in children and adolescents with type 1 (LQT1) and type 2 (LQT2) long-QT syndrome. METHODS AND RESULTS: QTc intervals of 12-lead resting electrocardiograms were determined, and trends over time were analyzed using a linear mixed-effects model...
April 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28350812/sports-related-sudden-cardiac-deaths-in-the-young-population-of-switzerland
#12
Babken Asatryan, Cristina Vital, Christoph Kellerhals, Argelia Medeiros-Domingo, Christoph Gräni, Lukas D Trachsel, Christian M Schmied, Ardan M Saguner, Prisca Eser, David Herzig, Stephan Bolliger, Katarzyna Michaud, Matthias Wilhelm
BACKGROUND: In Switzerland, ECG screening was first recommended for national squad athletes in 1998. Since 2001 it has become mandatory in selected high-risk professional sports. Its impact on the rates of sports-related sudden cardiac death (SCD) is unknown. OBJECTIVE: We aimed to study the incidence, causes and time trends of sports-related SCD in comparison to SCD unrelated to exercise in Switzerland. METHODS: We reviewed all forensic reports of SCDs of the German-speaking region of Switzerland in the age group of 10 to 39 years, occurring between 1999 and 2010...
2017: PloS One
https://www.readbyqxmd.com/read/28348152/pharmacokinetics-and-tolerance-of-the-phage-endolysin-based-candidate-drug-sal200-after-a-single-intravenous-administration-among-healthy-volunteers
#13
Soo Youn Jun, In Jin Jang, Seonghae Yoon, Kyungho Jang, Kyung-Sang Yu, Joo Youn Cho, Moon-Woo Seong, Gi Mo Jung, Seong Jun Yoon, Sang Hyeon Kang
This study is a phase 1, single-center, randomized, double-blind, placebo-controlled, single-dosing, and dose-escalating study of intravenous SAL200. It is a new candidate drug for antibiotic-resistant staphylococcal infections based on a recombinant form of the phage endolysin SAL-1. The study evaluated the pharmacokinetics, pharmacodynamics, and tolerance among healthy male volunteers after the intravenous infusion of single ascending doses of SAL200 (0.1, 0.3, 1, 3, and 10 mg/kg).SAL200 was well tolerated, and no serious adverse events (AEs) were observed in this clinical study...
March 27, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28340861/a-randomised-double-blind-placebo-controlled-long-term-extension-study-of-the-efficacy-safety-and-tolerability-of-fixed-dose-combinations-of-aclidinium-formoterol-or-monotherapy-in-the-treatment-of-chronic-obstructive-pulmonary-disease
#14
Anthony D'Urzo, Stephen Rennard, Edward Kerwin, James F Donohue, Alejhandra Lei, Eduard Molins, Anne Leselbaum
INTRODUCTION: Aclidinium bromide/formoterol fumarate (AB/FF) 400/12 μg efficacy and safety was demonstrated in two 6-month Phase III studies (AUGMENT and ACLIFORM) and a 12-month study in patients with moderate to severe chronic obstructive pulmonary disease (COPD). This Phase III, double-blind, placebo-controlled, 6-month AUGMENT extension investigated the long-term safety and tolerability of AB/FF 400/12 μg (NCT01572792). METHODS: Patients were randomised in AUGMENT (1:1:1:1:1) to twice-daily AB/FF 400/12 μg, AB/FF 400/6 μg, AB 400 μg, FF 12 μg or placebo...
April 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28288885/patients-with-ruptured-abdominal-aortic-aneurysm-have-become-higher-risk
#15
Anoosha Aslam, Charles M Fisher, Cathy Thoo, Michael L Neale, Shannon D Thomas
BACKGROUND: Independent risk factors such as age, loss of consciousness, elevated serum creatinine, low hemoglobin, and electrocardiogram evidence of ischemia have previously been shown to predict mortality after ruptured abdominal aortic aneurysm (rAAA). With an aging Australian population, we sought to determine if patients presenting with rAAA now had more predictive risk factors for mortality and whether these factors remain predictive of mortality. METHODS: The records of all patients presenting with rAAA between January 1985 to December 1993 (past era, group 1) and January 2007 to December 2011 (modern era, group 2) were retrieved...
March 11, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28278167/superior-success-rate-of-intracavitary-electrocardiogram-guidance-for-peripherally-inserted-central-catheter-placement-in-patients-with-cancer-a-randomized-open-label-controlled-multicenter-study
#16
Ling Yuan, Rongmei Li, Aifeng Meng, Yuling Feng, Xiancui Wu, Yiqun Yang, Ping Chen, Zhenzhu Qiu, Jing Qi, Chuanying Chen, Jia Wei, Minyi Qin, Weiwei Kong, Xiangyu Chen, Wei Xu
BACKGROUND: Intracavitary electrocardiogram (IC ECG) guidance emerges as a new technique for peripherally inserted central catheters (PICCs) placement and demonstrates many potential advantages in recent observational studies. AIMS: To determine whether IC ECG-guided PICCs provide more accurate positioning of catheter tips compared to conventional anatomical landmarks in patients with cancer undergoing chemotherapy. METHODS: In this multicenter, open-label, randomized controlled study (ClinicalTrials...
2017: PloS One
https://www.readbyqxmd.com/read/28268405/wearable-ecg-platform-for-continuous-cardiac-monitoring
#17
S P Preejith, R Dhinesh, Jayaraj Joseph, Mohanasankar Sivaprakasam
An ultra-low power ECG platform for continuous and minimally intrusive monitoring for systems with minimal processing capabilities, is presented in this paper. The platform is capable of detecting abnormalities in the ECG signal by extracting and analyzing features related to various cardiac trends. The platform is built to continuously operate on any of the 12 leads and the presented work includes a single lead implementation that works on lead I or II. A single lead, wearable ECG patch that can detect rhythm based arrhythmias and continuously monitor beat-to-beat heart rate and respiratory rate has been developed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268310/towards-24-7-continuous-heart-rate-monitoring
#18
Adrian Tarniceriu, Jakub Parak, Philippe Renevey, Marko Nurmi, Mattia Bertschi, Ricard Delgado-Gonzalo, Ilkka Korhonen
Heart rate (HR) and HR variability (HRV) carry rich information about physical activity, mental and physical load, physiological status, and health of an individual. When combined with activity monitoring and personalized physiological modelling, HR/HRV monitoring may be used for monitoring of complex behaviors and impact of behaviors and external factors on the current physiological status of an individual. Optical HR monitoring (OHR) from wrist provides a comfortable and unobtrusive method for HR/HRV monitoring and is better adhered by users than traditional ECG electrodes or chest straps...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28251667/a-comparison-of-the-pharmacokinetics-and-safety-of-enzalutamide-in-subjects-with-hepatic-impairment-and-matched-healthy-subjects
#19
W Krauwinkel, J Noukens, J van Dijk, S Popa, T Ouatas, M de Vries, D Phung, J Gibbons, J Mordenti, L Mateva
WHAT IS KNOWN AND OBJECTIVE: Enzalutamide is an androgen receptor inhibitor approved for treatment of metastatic castration-resistant prostate cancer. Enzalutamide is highly protein bound and eliminated primarily by hepatic metabolism; therefore, it is important to understand whether enzalutamide pharmacokinetics is altered by hepatic impairment. METHODS: Pharmacokinetic data were obtained from two non-randomized, open-label, single-dose, phase 1 studies conducted in patients with mild (Child-Pugh class A, n = 6) or moderate (Child-Pugh class B, n = 8) hepatic impairment (NCT01901133) or severe (Child-Pugh class C, n = 8) hepatic impairment (NCT02138162) and their corresponding matched healthy controls; data from both studies are presented here...
March 1, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28248005/evaluation-of-the-ecg-based-selvester-scoring-method-to-estimate-myocardial-scar-burden-and-predict-clinical-outcome-in-patients-with-left-bundle-branch-block-with-comparison-to-late-gadolinium-enhancement-cmr-imaging
#20
Uzma Chaudhry, Pyotr G Platonov, Robert Jablonowski, Jean-Philippe Couderc, Henrik Engblom, Xiajuang Xia, Björn Wieslander, Brett D Atwater, David G Strauss, Jesper Van der Pals, Martin Ugander, Marcus Carlsson, Rasmus Borgquist
BACKGROUND: Myocardial scar burden quantification is an emerging clinical parameter for risk stratification of sudden cardiac death and prediction of ventricular arrhythmias in patients with left ventricular dysfunction. We investigated the relationships among semiautomated Selvester score burden and late gadolinium enhancement-cardiovascular magnetic resonance (LGE-CMR) assessed scar burden and clinical outcome in patients with underlying heart failure, left bundle branch block (LBBB) and implantable cardioverter-defibrillator (ICD) treatment...
March 1, 2017: Annals of Noninvasive Electrocardiology
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