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https://www.readbyqxmd.com/read/29663176/serum-magnesium-and-risk-of-incident-heart-failure-in-older-men-the-british-regional-heart-study
#1
Sasiwarang Goya Wannamethee, Olia Papacosta, Lucy Lennon, Peter H Whincup
To examine the association between serum magnesium and incident heart failure (HF) in older men and investigate potential pathways including cardiac function, inflammation and lung function. Prospective study of 3523 men aged 60-79 years with no prevalent HF or myocardial infarction followed up for a mean period of 15 years, during which 268 incident HF cases were ascertained. Serum magnesium was inversely associated with many CVD risk factors including prevalent atrial fibrillation, lung function (FEV1 ) and markers of inflammation (IL-6), endothelial dysfunction (vWF) and cardiac dysfunction [NT-proBNP and cardiac troponin T (cTnT)]...
April 17, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29622458/usefulness-of-a-clinical-risk-score-to-predict-the-response-to-cardiac-resynchronization-therapy
#2
Rui Providencia, Eloi Marijon, Sergio Barra, Christian Reitan, Alexander Breitenstein, Pascal Defaye, Nikolaos Papageorgiou, Rudolph Duehmke, Stephan Winnik, Richard Ang, Didier Klug, Daniel Gras, Tardu Oezkartal, Oliver R Segal, Jean-Claude Deharo, Christophe Leclercq, Pier D Lambiase, Laurent Fauchier, Pierre Bordachar, Jan Steffel, Nicolas Sadoul, Olivier Piot, Rasmus Borgquist, Sharad Agarwal, Anthony Chow, Serge Boveda
BACKGROUND: Almost 1/3 of heart failure patients fail to respond to cardiac resynchronization therapy (CRT). A simple clinical score to predict who these patients are at the moment of referral or at time of implant may be of importance for early optimization of their management. METHODS: Observational study. A risk score was derived from factors associated to CRT response. The derivation cohort was composed of 1301 patients implanted with a CRT defibrillator in a multi-center French cohort-study...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29605590/measurement-of-fat-fraction-in-the-human-thymus-by-localized-nmr-and-three-point-dixon-mri-techniques
#3
Kenneth W Fishbein, Sokratis K Makrogiannis, Vanessa A Lukas, Marilyn Okine, Ramona Ramachandran, Luigi Ferrucci, Josephine M Egan, Chee W Chia, Richard G Spencer
PURPOSE: To develop a protocol to non-invasively measure and map fat fraction, fat/(fat+water), as a function of age in the adult thymus for future studies monitoring the effects of interventions aimed at promoting thymic rejuvenation and preservation of immunity in older adults. MATERIALS AND METHODS: Three-dimensional spoiled gradient echo 3T MRI with 3-point Dixon fat-water separation was performed at full inspiration for thymus conspicuity in 36 volunteers 19 to 56 years old...
March 29, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29581199/is-exposure-to-ionising-radiation-associated-with-childhood-cardiac-arrhythmia-in-the-russian-territories-contaminated-by-the-chernobyl-fallout-a-cross-sectional-population-based-study
#4
Jean-Rene Jourdain, Geraldine Landon, Enora Clero, Vladimir Doroshchenko, Aleksandr Silenok, Irina Kurnosova, Andrei Butsenin, Isabelle Denjoy, Didier Franck, Jean-Pierre Heuze, Patrick Gourmelon
OBJECTIVE: To investigate childhood cardiac arrhythmia and chronic exposure to caesium-137 (137 Cs) resulting from the Chernobyl accident. DESIGN: Prospective cross-sectional study using exposed/unexposed design conducted in the Bryansk region from May 2009 to May 2013 on children selected on the basis of137 Cs soil deposition: control territories ([137 Cs]<37 kBq per square metre, where children were considered as unexposed) and contaminated territories ([137 Cs]>555 kBq per square metre, where children were considered as exposed)...
March 25, 2018: BMJ Open
https://www.readbyqxmd.com/read/29558433/an-energy-efficient-algorithm-for-wearable-electrocardiogram-signal-processing-in-ubiquitous-healthcare-applications
#5
Ali Hassan Sodhro, Arun Kumar Sangaiah, Gul Hassan Sodhro, Sonia Lohano, Sandeep Pirbhulal
Rapid progress and emerging trends in miniaturized medical devices have enabled the un-obtrusive monitoring of physiological signals and daily activities of everyone's life in a prominent and pervasive manner. Due to the power-constrained nature of conventional wearable sensor devices during ubiquitous sensing (US), energy-efficiency has become one of the highly demanding and debatable issues in healthcare. This paper develops a single chip-based wearable wireless electrocardiogram (ECG) monitoring system by adopting analog front end (AFE) chip model ADS1292R from Texas Instruments...
March 20, 2018: Sensors
https://www.readbyqxmd.com/read/29542414/clinical-presentation-quality-of-care-risk-factors-and-outcomes-in-women-with-acute-st-elevation-myocardial-infarction-stemi-an-observational-report-from-six-middle-eastern-countries
#6
Abdulla Shehab, Khalid F AlHabib, Akshaya Srikanth Bhagavathul, Ahmad Hersi, Hussam Alfaleh, Mostafa Q Alshamiri, Anhar Ullah, Khadim Sulaiman, Wael Almahmeed, Jassim Al Suwaidi, Alwai A Alsheikh-Ali, Haitham Amin, Mohammed Al Jarallah, Amar M Salam
BACKGROUND: Most of the available literature on ST-Elevated myocardial infarction (STEMI) in women was conducted in the developed world and data from Middle-East countries was limited. AIM: To examine the clinical presentation, patient management, quality of care, risk factors and in-hospital outcomes of women with acute STEMI compared with men using data from a large STEMI registry from the Middle East. METHODS: Data were derived from the third Gulf Registry of Acute Coronary Events (Gulf RACE-3Ps), a prospective, multinational study of adults with acute STEMI from 36 hospitals in 6 Middle-Eastern countries...
March 14, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29505915/the-influence-of-betamethasone-on-fetal-heart-rate-variability-obtained-by-non-invasive-fetal-electrocardiogram-recordings
#7
Kim M J Verdurmen, Guy J J Warmerdam, Carlijn Lempersz, Alexandra D J Hulsenboom, Joris Renckens, Jeanne P Dieleman, Rik Vullings, Judith O E H van Laar, S Guid Oei
BACKGROUND: Betamethasone is widely used to enhance fetal lung maturation in case of threatened preterm labour. Fetal heart rate variability is one of the most important parameters to assess in fetal monitoring, since it is a reliable indicator for fetal distress. AIM: To describe the effect of betamethasone on fetal heart rate variability, by applying spectral analysis on non-invasive fetal electrocardiogram recordings. STUDY DESIGN: Prospective cohort study...
March 2, 2018: Early Human Development
https://www.readbyqxmd.com/read/29503381/the-national-integrated-project-for-prospective-observation-of-non-communicable-disease-and-its-trends-in-the-aged-2010-nippon-data2010-objectives-design-and-population-characteristics
#8
Aya Kadota, Nagako Okuda, Takayoshi Ohkubo, Tomonori Okamura, Nobuo Nishi, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura
BACKGROUND: The structure and risk factors for cardiovascular diseases (CVD) in Japan may change because lifestyle, particularly nutrition, socioeconomic status, and medical care, which affect CVD, may markedly change over time. Therefore, a new prospective cohort study on a representative general Japanese population based on national surveys is required. METHODS: In November 2010, the baseline survey of the National Integrated Project for Prospective Observation of Non-communicable Disease and its Trends in the Aged 2010 (NIPPON DATA2010) was performed with the National Health and Nutrition Survey of Japan (NHNS2010) in 300 randomly selected districts throughout Japan...
2018: Journal of Epidemiology
https://www.readbyqxmd.com/read/29501704/effects-of-guanfu-total-base-on-bcl-2-and-bax-expression-and-correlation-with-atrial-fibrillation
#9
Yan Li, Bingxue Song, Chuanjin Xu
OBJECTIVE: This study sought to investigate the effects of Guanfu total base on Bcl-2 and Bax expression and the correlation of Bcl-2 and Bax expression with atrial fibrillation. METHODS: Twenty-four male Sprague-Dawley rats were randomly divided into control, model, and treatment groups (n = 8 each). A combined intravenous injection of CaCl2 (10 mg/mL) and acetylcholine (Ach; 66 μg/mL) was administered to the model and treatment groups for 7 consecutive days to induce atrial fibrillation...
March 6, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29496772/electrocardiographic-correlates-of-acute-allograft-rejection-among-heart-transplant-recipients
#10
Kathleen T Hickey, Robert R Sciacca, Belinda Chen, Barbara J Drew, David Pickham, Erik V Carter, Carmen Castillo, Lynn V Doering
BACKGROUND: Acute allograft rejection appears to be associated with increases in QT/QTc intervals. OBJECTIVES: To determine the relationship between acute allograft rejection and electrocardiogram changes in patients undergoing an orthotopic heart transplant. METHODS: The study population comprised 220 adult patients undergoing heart transplant and enrolled in the NEW HEART study. Electrocardiograms obtained within 72 hours of endomyocardial biopsy were analyzed; electrocardiograms obtained fewer than 10 days after transplant surgery were excluded...
March 2018: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/29480582/nt-probnp-is-associated-with-mortality-and-adverse-cardiac-events-in-patients-with-atrial-fibrillation-presenting-to-the-emergency-department
#11
Marijn J Holl, Ewout J van den Bos, Ron T van Domburg, Michael A Fouraux, Marcel J Kofflard
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia in the emergency department. The CHA2 DS2 -VASc score helps to predict thromboembolic risk; however, the rate of other adverse cardiac events is more difficult to predict. HYPOTHESIS: The biomarker N-terminal pro-brain natriuretic peptide (NT-proBNP) has prognostic value in patients presenting to the emergency department with AF. METHODS: During a 1.5-year period, a prospective study was performed in consecutive patients presenting to the emergency department with AF on the presenting electrocardiogram...
February 26, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29459303/the-human-skin-as-a-sub-thz-receiver-does-5g-pose-a-danger-to-it-or-not
#12
Noa Betzalel, Paul Ben Ishai, Yuri Feldman
In the interaction of microwave radiation and human beings, the skin is traditionally considered as just an absorbing sponge stratum filled with water. In previous works, we showed that this view is flawed when we demonstrated that the coiled portion of the sweat duct in upper skin layer is regarded as a helical antenna in the sub-THz band. Experimentally we showed that the reflectance of the human skin in the sub-THz region depends on the intensity of perspiration, i.e. sweat duct's conductivity, and correlates with levels of human stress (physical, mental and emotional)...
February 16, 2018: Environmental Research
https://www.readbyqxmd.com/read/29438471/severity-of-chagasic-cardiomyopathy-is-associated-with-response-to-a-novel-rapid-diagnostic-test-for-trypanosoma-cruzi-tcii-v-vi
#13
Tapan Bhattacharyya, Louisa A Messenger, Caryn Bern, Pascal Mertens, Quentin Gilleman, Nicolas Zeippen, Bruno C Bremer Hinckel, Niamh Murphy, Robert H Gilman, Michael A Miles
Background: Trypanosoma cruzi causes Chagas disease in the Americas. Outcome of infection ranges from lifelong asymptomatic status to severe disease. Understanding how history of T. cruzi lineage (TcI-TcVI) infection relates to clinical prognosis is challenging. We previously described peptide-based lineage-specific ELISA with Trypomastigote Small Surface Antigen (TSSA). Methods: A novel rapid diagnostic test (Chagas Sero K-SeT) incorporating a peptide corresponding to the TSSA-II/V/VI common epitope was developed, and validated by comparison with ELISA...
February 9, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29415807/improvement-of-door-to-electrocardiogram-time-using-the-first-nurse-role-in-the-ed-setting
#14
Laura Stanfield
INTRODUCTION: This quality improvement project compared door-to-electrocardiogram (ECG) times for patients presenting with symptoms suggestive of acute coronary syndrome within a community hospital emergency department before and after first-nurse (emergency nurse stationed in the ED waiting room) training. METHOD: Door-to-ECG time was compared before and after the educational intervention using Acute Coronary Treatment and Intervention Outcomes Network (ACTION) registry data reported by the facility...
February 4, 2018: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/29373611/accuracy-and-reliability-of-noninvasive-stroke-volume-monitoring-via-ecg-gated-3d-electrical-impedance-tomography-in-healthy-volunteers
#15
Fabian Braun, Martin Proença, Andy Adler, Thomas Riedel, Jean-Philippe Thiran, Josep Solà
Cardiac output (CO) and stroke volume (SV) are parameters of key clinical interest. Many techniques exist to measure CO and SV, but are either invasive or insufficiently accurate in clinical settings. Electrical impedance tomography (EIT) has been suggested as a noninvasive measure of SV, but inconsistent results have been reported. Our goal is to determine the accuracy and reliability of EIT-based SV measurements, and whether advanced image reconstruction approaches can help to improve the estimates. Data were collected on ten healthy volunteers undergoing postural changes and exercise...
2018: PloS One
https://www.readbyqxmd.com/read/29325362/-predicting-value-of-2014-european-guidelines-risk-prediction-model-for-sudden-cardiac-death-hcm-risk-scd-in-chinese-patients-with-hypertrophic-cardiomyopathy
#16
W X Li, L W Liu, J Wang, L Zuo, F Yang, N Kang, C H Lei
Objective: To evaluate the predicting value of the 2014 European Society of Cardiology (ESC) guidelines risk prediction model for sudden cardiac death (HCM Risk-SCD) in Chinese patients with hypertrophic cardiomyopathy (HCM), and to explore the predictors of adverse cardiovascular events in Chinese HCM patients. Methods: The study population consisted of a consecutive 207 HCM patients admitted in our center from October 2014 to October 2016. All patients were followed up to March 2017. The 5-year SCD probability of each patient was estimated using HCM Risk-SCD model based on electrocardiogram, echocardiography and cardiac magnetic resonance (CMR) examination results...
December 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29306465/prognostic-significance-of-qrs-fragmentation-and-correlation-with-infarct-size-in-patients-with-anterior-st-segment-elevation-myocardial-infarction-treated-with-percutaneous-coronary-intervention-insights-from-the-infuse-ami-trial
#17
Björn Redfors, Ioanna Kosmidou, Aaron Crowley, Akiko Maehara, Ori Ben-Yehuda, Arslan Arif, José M Dizon, Gary S Mintz, Gregg W Stone
BACKGROUND: QRS fragmentation (fQRS) is believed to reflect myocardial scar formation in patients with coronary disease. Whether early formation of fQRS in patients with ST-segment elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI) is correlated with infarct size and prognosis is unknown. We assessed the prognostic value of fQRS at 60min post-PCI and its correlation with infarct size in patients with anterior STEMI managed with primary PCI. METHODS: The INFUSE-AMI trial enrolled 452 patients with anterior STEMI undergoing primary PCI...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29304859/a-phase-1-evaluation-of-the-pharmacokinetic-pharmacodynamic-interaction-of-the-anti-malarial-agents-kaf156-and-piperaquine
#18
F Joel Leong, Jay Prakash Jain, Yiyan Feng, Budhaditya Goswami, Daniel S Stein
BACKGROUND: KAF156 is a novel imidazolopiperazine anti-malarial with activity against pre-erythrocytic liver stages, asexual and sexual blood stages. Based on in vitro data, a two-way pharmacokinetic interaction was hypothesized for KAF156 use in combination with piperaquine (PPQ) as both drugs are CYP3A4 substrates and inhibitors. Potential combination effects on the QT interval were also assessed. METHODS: This was an open-label, parallel-group, single-dose study in healthy volunteers randomized to three parallel arms (1:1:1) of 800 mg KAF156 + 1280 mg PPQ, 800 mg KAF156 alone and 1280 mg PPQ alone...
January 5, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29288015/trends-in-co-morbidities-and-survival-for-in-hospital-cardiac-arrest-a-swedish-cohort-study
#19
Patrik Hjalmarsson, Mahta Memar, Sammy-Jo Geara, Mathilde Bouzereau, Anna Allberg, Abdelaziz Elgadi, Eva Piscator, Therese Djärv
OBJECTIVES: Co-morbidities affect survival after in-hospital cardiac arrests (IHCA). The risk population for IHCA, i.e. the hospitalised patients, have a doubled increase in co-morbidities over time. A similar increase in co-morbidities among IHCAs might explain the relatively poor survival ratios despite improved care. AIM: To assess changes in the burden of baseline age-adjusted Charlson co-morbidity index (ACCI) scores among IHCAs as well as to assess its impact on survival in three time periods...
March 2018: Resuscitation
https://www.readbyqxmd.com/read/29275944/electrocardiographic-patterns-and-long-term-training-induced-time-changes-in-2484-elite-football-players
#20
Olivier Huttin, Christine Selton-Suty, Clément Venner, Jean-Baptiste Vilain, Pierre Rochecongar, Etienne Aliot
BACKGROUND: High-level physical training induces cardiac structural and functional changes, including 12-lead electrocardiogram modifications. OBJECTIVES: The purpose of this cross-sectional longitudinal study was to establish a quantitative electrocardiographic profile in highly trained football players. Initial and serial annual electrocardiogram monitoring over subsequent years allowed us to investigate the long-term effects of exercise on cardiac conduction and electrophysiological remodelling...
December 21, 2017: Archives of Cardiovascular Diseases
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