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https://www.readbyqxmd.com/read/28109825/trends-in-coronary-risk-factors-and-electrocardiogram-findings-from-1977-to-2009-with-10-year-mortality-in-japanese-elderly-males-the-tanushimaru-study
#1
Sachiko Nakamura, Hisashi Adachi, Mika Enomoto, Ako Fukami, Eita Kumagai, Yume Nohara, Shoko Kono, Erika Nakao, Akiko Sakaue, Tomoko Tsuru, Nagisa Morikawa, Yoshihiro Fukumoto
BACKGROUND: An understanding of the trends in regard to coronary risk factors and electrocardiogram (ECG) findings has an important role in public health. We investigated the trends in coronary risk factors and main ECG findings in 1977, 1989, 1999, and 2009 in the Japanese cohort of the Seven Countries Study, in Tanushimaru, a typical farming town on Kyushu Island. METHODS AND RESULTS: A total of 1397 subjects (231 in 1977, 332 in 1989, 389 in 1999, and 445 in 2009) were enrolled in this study, and all of them were males aged over 65 years...
January 18, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28093803/novel-ecg-synchronized-pulsatile-ecls-system-with-various-heart-rates-and-cardiac-arrhythmias-an-in-vitro-study
#2
Shigang Wang, Shannon B Spencer, Allen R Kunselman, Akif Ündar
The objective of this study is to evaluate electrocardiography (ECG)-synchronized pulsatile flow under varying heart rates and different atrial and ventricular arrhythmias in a simulated extracorporeal life support (ECLS) system. The ECLS circuit consisted of an i-cor diagonal pump and console, an iLA membrane ventilator, and an 18 Fr arterial cannula. The circuit was primed with lactated Ringer's solution and packed red blood cells (hematocrit 35%). An ECG simulator was used to trigger pulsatile flow and to generate selected cardiac rhythms...
January 2017: Artificial Organs
https://www.readbyqxmd.com/read/28089154/pre-hospital-electrocardiogram-triage-with-telemedicine-near-halves-time-to-treatment-in-stemi-a-meta-analysis-and-meta-regression-analysis-of-non-randomized-studies
#3
REVIEW
Natale Daniele Brunetti, Luisa De Gennaro, Michele Correale, Francesco Santoro, Pasquale Caldarola, Antonio Gaglione, Matteo Di Biase
BACKGROUND: A shorter time to treatment has been shown to be associated with lower mortality rates in acute myocardial infarction (AMI). Several strategies have been adopted with the aim to reduce any delay in diagnosis of AMI: pre-hospital triage with telemedicine is one of such strategies. We therefore aimed to measure the real effect of pre-hospital triage with telemedicine in case of AMI in a meta-analysis study. METHODS: We performed a meta-analysis of non-randomized studies with the aim to quantify the exact reduction of time to treatment achieved by pre-hospital triage with telemedicine...
January 8, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28087972/lack-of-effect-of-oral-cabotegravir-on-the-pharmacokinetics-of-a-levonorgestrel-ethinyl-estradiol-containing-oral-contraceptive-in-healthy-adult-females
#4
C Trezza, S L Ford, E Gould, Y Lou, C Huang, J M Ritter, A M Buchanan, W Spreen, P Patel
AIM(S): This study aimed to investigate whether cabotegravir (CAB), an integrase inhibitor in development for treatment and prevention of HIV-1, influences the pharmacokinetics (PK) of a levonorgestrel (LNG) and ethinyl estradiol (EE)-containing oral contraceptive (OC) in healthy women. METHODS: In this open-label, fixed-sequence crossover study, healthy female subjects received LNG 0.15 mg/EE 0.03 mg tablet once daily Days 1-10 alone and with oral CAB 30 mg once daily Days 11-21...
January 14, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28071824/heart-rate-variability-in-leucine-rich-repeat-kinase-2-associated-parkinson-s-disease
#5
Naomi P Visanji, Grace S Bhudhikanok, Tiago A Mestre, Taneera Ghate, Kaviraj Udupa, Amaal AlDakheel, Barbara S Connolly, Carmen Gasca-Salas, Drew S Kern, Jennifer Jain, Elizabeth J Slow, Achinoam Faust-Socher, Sam Kim, Ruksana Azhu Valappil, Farah Kausar, Ekaterina Rogaeva, J William Langston, Caroline M Tanner, Birgitt Schüle, Anthony E Lang, Samuel M Goldman, Connie Marras
BACKGROUND: Heart rate variability is reduced in idiopathic PD, indicating cardiac autonomic dysfunction likely resulting from peripheral autonomic synucleinopathy. Little is known about heart rate variability in leucine-rich repeat kinase 2-associated PD. OBJECTIVES: This study investigated heart rate variability in LRRK2-associated PD. METHODS: Resting electrocardiograms were obtained from 20 individuals with LRRK2-associated PD, 37 nonmanifesting carriers, 48 related noncarriers, 26 idiopathic PD patients, and 32 controls...
January 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28070890/the-role-of-conventional-and-right-sided-ecg-screening-for-subcutaneous-icd-in-a-tetralogy-of-fallot-population
#6
Pau Alonso, Joaquín Osca, Oscar Cano, Pedro Pimenta, Ana Andrés, Jaime Yagüe, José Millet, Joaquín Rueda, María José Sancho-Tello
BACKGROUND: Information regarding suitability for S-ICD implant in Tetralogy of Fallot (ToF) population is scarce and needs to be further explored. THE AIMS OF OUR STUDY WERE: (i) to determine the proportion of patients with ToF eligible for S-ICD, (ii) to identify the optimal sensing vector in ToF patients, (iii) to test specifically the eligibility for sICD with right-sided screening, and (iv) to compare with the proportion of eligible patients in a non-selected ICD population...
January 10, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28056014/prevalence-of-chagas-disease-in-a-u-s-population-of-latin-american-immigrants-with-conduction-abnormalities-on-electrocardiogram
#7
Mahmoud I Traina, Salvador Hernandez, Daniel R Sanchez, Jalal Dufani, Mohsin Salih, Adieb M Abuhamidah, Wilman Olmedo, Jason S Bradfield, Colin J Forsyth, Sheba K Meymandi
Chagas disease (CD) affects over six million people and is a leading cause of cardiomyopathy in Latin America. Given recent migration trends, there is a large population at risk in the United States (US). Early stage cardiac involvement from CD usually presents with conduction abnormalities on electrocardiogram (ECG) including right bundle branch block (RBBB), left anterior or posterior fascicular block (LAFB or LPFB, respectively), and rarely, left bundle branch block (LBBB). Identification of disease at this stage may lead to early treatment and potentially delay the progression to impaired systolic function...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28006108/preliminary-assessment-of-safety-pharmacokinetics-and-dose-finding-for-digitoxin-for-airway-inflammation-in-cystic-fibrosis
#8
Pamela L Zeitlin, Marie Diener-West, Karen A Callahan, Seakwoo Lee, C Conover Talbot, Bette Pollard, Michael P Boyle, Noah Lechtzin
RATIONALE: Cystic Fibrosis (CF) lung disease progresses by a combination of airways inflammation, bacterial colonization, and infection. Airways inflammation is predominantly neutrophilic and complicates airway clearance therapies through cellular debris, excessive DNA, excessive and viscous mucous, and high concentrations of neutrophils, Il-8 and related cytokines liberated along the NFkB signaling pathway. OBJECTIVE: We conducted a single site, randomized, double blind, placebo-controlled, preliminary study in which we evaluated the effects of 28 days of two dose levels (0...
December 22, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27995643/loperamide-trends-in-abuse-and-misuse-over-13-years-2002-2015
#9
Daniel R Lasoff, Cynthia H Koh, Bryan Corbett, Alicia B Minns, F Lee Cantrell
STUDY OBJECTIVE: With the increasing amount of information available on the Internet describing techniques for using loperamide either for self-treatment of opioid withdrawal syndromes or for recreational use ("legal highs"), the objective was to describe a statewide poison control system's experience with loperamide misuse and abuse, with specific interest in cases of cardiotoxicity, and to determine if there has been a recent increase in reported loperamide misuse or abuse cases. DESIGN: Retrospective review...
December 20, 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27987028/left-ventricular-function-in-response-to-dipyridamole-stress-head-to-head-comparison-between-82-rubidium-pet-and-99m-tc-sestamibi-spect-ecg-gated-myocardial-perfusion-imaging
#10
Maria Clementina Giorgi, Jose Claudio Meneghetti, Jose Soares, Marisa Izaki, Andréa Falcão, Rodrigo Imada, William Chalela, Marco Antonio de Oliveira, Cesar Nomura, Hein J Verberne
PURPOSE: Myocardial perfusion imaging (MPI) with (99m)Tc-sestamibi (sestamibi) SPECT and rubidium-82 ((82)Rb) PET both allow for combined assessment of perfusion and left ventricular (LV) function. We sought to compare parameters of LV function obtained with both methods using a single dipyridamole stress dose. MATERIALS AND METHODS: A group of 221 consecutive patients (65.2 ± 10.4 years, 52.9% male) underwent consecutive sestamibi and (82)Rb MPI after a single dipyridamole stress dose...
December 16, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27966001/cortisol-brain-derived-neurotrophic-factor-ratio-associated-with-silent-ischaemia-in-a-black-male-cohort-the-sa-bpa-study
#11
Christiaan E Schutte, Leoné Malan, Jacobus D Scheepers, Woudri Oosthuizen, Marike Cockeran, Nicolaas T Malan
AIM: Emotional distress has been associated with cardiovascular disease (CVD) in Africans. Cortisol and brain-derived neurotrophic factor (BDNF), as markers of emotional distress, increase cardiometabolic risk. We therefore aimed to investigate associations between cardiometabolic risk markers and the cortisol-to-BDNF ratio (cortisol:BDNF). METHODS: A cross-sectional study included a bi-ethnic gender cohort (n = 406) aged 44.7 ± 9.52 years. Ambulatory blood pressure (ABPM), ECG, fasting serum cortisol and BDNF levels and cardiometabolic risk markers were obtained...
November 2016: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/27943311/fv-100-versus-valacyclovir-for-the-prevention-of-post-herpetic-neuralgia-and-the-treatment-of-acute-herpes-zoster-associated-pain-a-randomized-controlled-trial
#12
Stephen K Tyring, Patricia Lee, Gordon T Hill, Joel C Silverfield, Angela Yen Moore, Theresa Matkovits, John Sullivan-Bolyai
This prospective, parallel-group, randomized, double-blind, multicenter study compared the efficacy and safety of FV-100 with valacyclovir for reducing pain associated with acute herpes zoster (HZ). Patients, ≥50 years of age, diagnosed with HZ within 72 h of lesion appearance who had HZ-associated pain, were randomized 1:1:1 to a 7-day course of either FV-100 200 mg QD (n = 117), FV-100 400 mg QD (n = 116), or valacyclovir 1000 mg TID (n =117). Efficacy was evaluated on the basis of the burden of illness (BOI; Zoster Brief Pain Inventory scores); incidence and duration of clinically significant pain (CSP); pain scores; incidence and severity of post-herpetic neuralgia (PHN); and times to full lesion crusting and to lesion healing...
December 12, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27931004/increasing-trend-of-wearables-and-multimodal-interface-for-human-activity-monitoring-a-review
#13
REVIEW
Preeti Kumari, Lini Mathew, Poonam Syal
Activity recognition technology is one of the most important technologies for life-logging and for the care of elderly persons. Elderly people prefer to live in their own houses, within their own locality. If, they are capable to do so, several benefits can follow in terms of society and economy. However, living alone may have high risks. Wearable sensors have been developed to overcome these risks and these sensors are supposed to be ready for medical uses. It can help in monitoring the wellness of elderly persons living alone by unobtrusively monitoring their daily activities...
April 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27929709/safety-of-buprenorphine-transdermal-system-in-the-management-of-pain-in-older-adults
#14
Joseph V Pergolizzi, Robert B Raffa, Zachary Marcum, Salvatore Colucci, Steven R Ripa
OBJECTIVES: To evaluate whether buprenorphine transdermal system (BTDS; Butrans®) is an option for the treatment of chronic pain in older adults. METHODS: This retrospective analysis of 16 placebo- and active-controlled and uncontrolled studies (N = 6566) evaluated the safety and tolerability profile in patients exposed to BTDS and compared the safety profiles associated with BTDS treatment in older patients ≥ 65 years of age (65 to 98 years) and younger patients < 65 years of age (18 to 64 years)...
December 26, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27919901/safety-and-pharmacokinetics-of-cd101-iv-a-novel-echinocandin-in-healthy-adults
#15
Taylor Sandison, Voon Ong, Jonathan Lee, Dirk Thye
CD101 IV is a novel echinocandin with distinctive pharmacokinetic properties that is being developed as a once-weekly treatment for candidemia and invasive candidiasis. CD101 has potent in vitro activity and in vivo efficacy against a broad range of Candida and Aspergillus species. The primary objective of two randomized, double-blind, placebo-controlled, dose-escalation studies in healthy adults was to determine the safety and tolerability of CD101 IV. Sequential cohorts of 8 subjects (n=6, active; n=2, placebo) were administered single (50, 100, 200, 400 mg) or multiple once-weekly (100 mg ×2, 200 mg ×2, 400 mg ×3) doses of CD101 IV infused over 1 hour...
December 5, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27894284/proarrhythmic-risk-and-determinants-of-cardiac-autonomic-dysfunction-in-collagen-induced-arthritis-rats
#16
Ting-Tse Lin, Yen-Ling Sung, Chih-En Wu, Hong Zhang, Yen-Bin Liu, Shien-Fong Lin
BACKGROUNDS: Patients with rheumatoid arthritis (RA) have increased risk of sudden cardiac death (SCD), which is two-fold higher than general population. The driving cause of SCD was considered due to lift-threatening arrhythmia where systemic inflammation acts as the pathophysiological basis linking RA to autonomicdysfunction. METHODS: To assess the sympathetic over-activity of "inflammatory reflex", we measured heart rate variability (HRV) in a rat collagen-induced arthritis (CIA) model, whose arthritis is induced in Lewis rats by intradermal injection of emulsion of type II collagen...
November 29, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27856811/increased-heart-rate-is-associated-with-a-prothrombotic-state-the-framingham-heart-study
#17
Geoffrey H Tofler, Joseph Massaro, Daniel A Levy, Patrice A Sutherland, Thomas Buckley, Ralph B D'Agostino
BACKGROUND: Although a higher heart rate is associated with an increased risk of cardiovascular disease, the mechanism is not well understood. As thrombosis has an important role in plaque development and acute coronary syndromes, the increase related to heart rate may result from a prothrombotic imbalance. METHODS: We investigated the relation between heart rate and thrombotic potential in 3451 participants from the Offspring Cohort of the Framingham Heart Study (mean age 54 years, 55% women)...
November 17, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27835715/ziprasidone-augmentation-of-escitalopram-for-major-depressive-disorder-cardiac-endocrine-metabolic-and-motoric-effects-in-a-randomized-double-blind-placebo-controlled-study
#18
David Mischoulon, Richard C Shelton, Lee Baer, William V Bobo, Laura Curren, Maurizio Fava, George I Papakostas
OBJECTIVE: To examine motoric, cardiovascular, endocrine, and metabolic effects of adjunctive ziprasidone in adults with major depressive disorder (MDD) and prior nonresponse to 8 weeks of open-label escitalopram. METHODS: A multicenter, parallel, randomized, double-blind, placebo-controlled trial was conducted at 3 US academic medical centers from July 2008 to October 2013. Recruited were 139 outpatients with persistent DSM-IV MDD following an 8-week open-label trial of escitalopram...
November 8, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27796540/effects-of-elotuzumab-on-qt-interval-and-cardiac-safety-in-patients-with-multiple-myeloma
#19
Chaitali Passey, Raymond Darbenzio, Ying-Ming Jou, Mark Lynch, Manish Gupta
PURPOSE: To assess the effect of elotuzumab on corrected QT (QTc) intervals and cardiac safety. METHODS: Patients with high-risk smoldering multiple myeloma who had been treated with elotuzumab monotherapy (10 or 20 mg/kg) in Study CA204011 (NCT01441973) underwent electrocardiogram (ECG) examination over 8-10 weeks (treatment cycles 1-3). ECG intervals and changes relative to baseline were assessed. The key ECG endpoint was change from baseline in QT interval corrected with Fridericia's method (ΔQTcF)...
October 28, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27753234/atrial-electrocardiography-in-obesity-and-hypertension-clinical-insights-from-the-polish-norwegian-study-pons
#20
Georgeta D Vaidean, Marta Manczuk, Jared W Magnani
OBJECTIVE: Obesity and hypertension often coexist and represent risk factors for atrial fibrillation. This study hypothesized that their single and joint effects on atrial remodeling would be reflected in the PR interval and P-wave durations on electrocardiogram (ECG). METHODS: This cross-sectional analysis of a community-based study included 11,308 men and women age 45-64. Atrial indices were obtained from digital standard 12-lead resting ECG. Analyses were adjusted for traditional cardiovascular risk factors...
October 18, 2016: Obesity
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