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https://www.readbyqxmd.com/read/28213055/electrophysiological-measurements-that-can-explain-and-guide-temporary-accelerated-pacing-to-avert-re-occurrence-of-torsade-de-pointes-arrhythmias-in-the-canine-chronic-atrioventricular-block-model
#1
Sofieke C Wijers, Alexandre Bossu, Albert Dunnink, Jet D M Beekman, Rosanne Varkevisser, Alfonso Aranda Hernández, Mathias Meine, Marc A Vos
BACKGROUND: Pacing at higher rates is known to suppress Torsade de Pointes (TdP) arrhythmias. Nevertheless, exact application and mechanism need further clarification. In the anesthetized, canine, chronic atrioventricular block model, ventricular remodeling is responsible for a high and reproducible incidence of TdP upon a challenge with dofetilide. OBJECTIVE: We used this model to investigate by what mechanism accelerated pacing averts TdP and what repolarization parameter could be used to guide temporary applied accelerated pacing (TAP)...
February 14, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28211883/the-inflammatory-state-provokes-sexual-dimorphism-in-left-ventricular-and-electrocardiographic-effects-of-chronic-cyclosporine-in-rats
#2
Hany M El-Bassossy, Zainy M Banjar, Mahmoud M El-Mas
Although cardiotoxicity has been recognized as an adverse effect of cyclosporine A (CSA), no information exists regarding sex specificity of CSA cardiotoxicity. We tested the hypothesis that left ventricular (LV) and electrocardiographic (ECG) effects of CSA and related inflammatory/histopathological derangements are sex related. CSA reduced the LV slope of end-systolic pressure volume relationship and increased isovolumic relaxation constant. These effects were more pronounced in male compared to female rats, suggesting LV systolic and diastolic dysfunction...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28194254/long-term-continuous-ambulatory-ecg-monitors-and-external-cardiac-loop-recorders-for-cardiac-arrhythmia-a-health-technology-assessment
#3
(no author information available yet)
BACKGROUND: Ambulatory electrocardiography (ECG) monitors are often used to detect cardiac arrhythmia. For patients with symptoms, an external cardiac loop recorder will often be recommended. The improved recording capacity of newer Holter monitors and similar devices, collectively known as longterm continuous ambulatory ECG monitors, suggests that they will perform just as well as, or better than, external loop recorders. This health technology assessment aimed to evaluate the effectiveness, cost-effectiveness, and budget impact of longterm continuous ECG monitors compared with external loop recorders in detecting symptoms of cardiac arrhythmia...
2017: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/28150186/serelaxin-in-acute-heart-failure-patients-with-and-without-atrial-fibrillation-a-secondary-analysis-of-the-relax-ahf-trial
#4
Gerasimos Filippatos, Dimitrios Farmakis, Marco Metra, Gad Cotter, Beth A Davison, G Michael Felker, Barry H Greenberg, Tsushung A Hua, Peter S Pang, Piotr Ponikowski, Min Qian, Thomas A Severin, Adriaan A Voors, John R Teerlink
BACKGROUND: Atrial fibrillation (AFib) is a common comorbidity in HF and affects patients' outcome. We sought to assess the effects of serelaxin in patients with and without AFib. METHODS: In a post hoc analysis of the RELAX-AHF trial, we compared the effects of serelaxin on efficacy end points, safety end points and biomarkers in 1161 patients with and without AFib on admission electrocardiogram. RESULTS: AFib was present in 41.3% of patients...
February 1, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28126148/usefulness-of-maintaining-a-normal-electrocardiogram-over-time-for-predicting-cardiovascular-health
#5
Elsayed Z Soliman, Zhu-Ming Zhang, Lin Y Chen, Larisa G Tereshchenko, Dan Arking, Alvaro Alonso
We hypothesized that maintaining a normal electrocardiogram (ECG) status over time is associated with low cardiovascular (CV) disease in a dose-response fashion and subsequently could be used to monitor programs aimed at promoting CV health. This analysis included 4,856 CV disease-free participants from the Atherosclerosis Risk in Communities study who had a normal ECG at baseline (1987 to 1989) and complete electrocardiographic data in subsequent 3 visits (1990 to 1992, 1993 to 1995, and 1996 to 1998). Participants were classified based on maintaining their normal ECG status during these 4 visits into "maintained," "not maintained," or "inconsistent" normal ECG status as defined by the Minnesota ECG classification...
January 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28113920/predicting-mood-changes-in-bipolar-disorder-through-heartbeat-nonlinear-dynamics
#6
Gaetano Valenza, Mimma Nardelli, Antonio Lanata', Claudio Gentili, Gilles Bertschy, Markus Kosel, Enzo Pasquale Scilingo
Bipolar Disorder (BD) is characterized by an alternation of mood states from depression to (hypo)mania. Mixed states, i.e., a combination of depression and mania symptoms at the same time, can also be present. The diagnosis of this disorder in the current clinical practice is based only on subjective interviews and questionnaires, while no reliable objective psychophysiological markers are available. Furthermore, there are no biological markers predicting BD outcomes, or providing information about the future clinical course of the phenomenon...
April 20, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28109825/trends-in-coronary-risk-factors-and-electrocardiogram-findings-from-1977-to-2009-with-10-year-mortality-in-japanese-elderly-males-the-tanushimaru-study
#7
Sachiko Nakamura, Hisashi Adachi, Mika Enomoto, Ako Fukami, Eita Kumagai, Yume Nohara, Shoko Kono, Erika Nakao, Akiko Sakaue, Tomoko Tsuru, Nagisa Morikawa, Yoshihiro Fukumoto
BACKGROUND: An understanding of the trends in regard to coronary risk factors and electrocardiogram (ECG) findings has an important role in public health. We investigated the trends in coronary risk factors and main ECG findings in 1977, 1989, 1999, and 2009 in the Japanese cohort of the Seven Countries Study, in Tanushimaru, a typical farming town on Kyushu Island. METHODS AND RESULTS: A total of 1397 subjects (231 in 1977, 332 in 1989, 389 in 1999, and 445 in 2009) were enrolled in this study, and all of them were males aged over 65 years...
January 18, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28093803/novel-ecg-synchronized-pulsatile-ecls-system-with-various-heart-rates-and-cardiac-arrhythmias-an-in-vitro-study
#8
Shigang Wang, Shannon B Spencer, Allen R Kunselman, Akif Ündar
The objective of this study is to evaluate electrocardiography (ECG)-synchronized pulsatile flow under varying heart rates and different atrial and ventricular arrhythmias in a simulated extracorporeal life support (ECLS) system. The ECLS circuit consisted of an i-cor diagonal pump and console, an iLA membrane ventilator, and an 18 Fr arterial cannula. The circuit was primed with lactated Ringer's solution and packed red blood cells (hematocrit 35%). An ECG simulator was used to trigger pulsatile flow and to generate selected cardiac rhythms...
January 2017: Artificial Organs
https://www.readbyqxmd.com/read/28089154/pre-hospital-electrocardiogram-triage-with-telemedicine-near-halves-time-to-treatment-in-stemi-a-meta-analysis-and-meta-regression-analysis-of-non-randomized-studies
#9
REVIEW
Natale Daniele Brunetti, Luisa De Gennaro, Michele Correale, Francesco Santoro, Pasquale Caldarola, Antonio Gaglione, Matteo Di Biase
BACKGROUND: A shorter time to treatment has been shown to be associated with lower mortality rates in acute myocardial infarction (AMI). Several strategies have been adopted with the aim to reduce any delay in diagnosis of AMI: pre-hospital triage with telemedicine is one of such strategies. We therefore aimed to measure the real effect of pre-hospital triage with telemedicine in case of AMI in a meta-analysis study. METHODS: We performed a meta-analysis of non-randomized studies with the aim to quantify the exact reduction of time to treatment achieved by pre-hospital triage with telemedicine...
January 8, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28087972/lack-of-effect-of-oral-cabotegravir-on-the-pharmacokinetics-of-a-levonorgestrel-ethinyl-estradiol-containing-oral-contraceptive-in-healthy-adult-females
#10
C Trezza, S L Ford, E Gould, Y Lou, C Huang, J M Ritter, A M Buchanan, W Spreen, P Patel
AIM(S): This study aimed to investigate whether cabotegravir (CAB), an integrase inhibitor in development for treatment and prevention of HIV-1, influences the pharmacokinetics (PK) of a levonorgestrel (LNG) and ethinyl estradiol (EE)-containing oral contraceptive (OC) in healthy women. METHODS: In this open-label, fixed-sequence crossover study, healthy female subjects received LNG 0.15 mg/EE 0.03 mg tablet once daily Days 1-10 alone and with oral CAB 30 mg once daily Days 11-21...
January 14, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28071824/heart-rate-variability-in-leucine-rich-repeat-kinase-2-associated-parkinson-s-disease
#11
Naomi P Visanji, Grace S Bhudhikanok, Tiago A Mestre, Taneera Ghate, Kaviraj Udupa, Amaal AlDakheel, Barbara S Connolly, Carmen Gasca-Salas, Drew S Kern, Jennifer Jain, Elizabeth J Slow, Achinoam Faust-Socher, Sam Kim, Ruksana Azhu Valappil, Farah Kausar, Ekaterina Rogaeva, J William Langston, Caroline M Tanner, Birgitt Schüle, Anthony E Lang, Samuel M Goldman, Connie Marras
BACKGROUND: Heart rate variability is reduced in idiopathic PD, indicating cardiac autonomic dysfunction likely resulting from peripheral autonomic synucleinopathy. Little is known about heart rate variability in leucine-rich repeat kinase 2-associated PD. OBJECTIVES: This study investigated heart rate variability in LRRK2-associated PD. METHODS: Resting electrocardiograms were obtained from 20 individuals with LRRK2-associated PD, 37 nonmanifesting carriers, 48 related noncarriers, 26 idiopathic PD patients, and 32 controls...
January 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28070890/the-role-of-conventional-and-right-sided-ecg-screening-for-subcutaneous-icd-in-a-tetralogy-of-fallot-population
#12
Pau Alonso, Joaquín Osca, Oscar Cano, Pedro Pimenta, Ana Andrés, Jaime Yagüe, José Millet, Joaquín Rueda, María José Sancho-Tello
BACKGROUND: Information regarding suitability for S-ICD implant in Tetralogy of Fallot (ToF) population is scarce and needs to be further explored. THE AIMS OF OUR STUDY WERE: (i) to determine the proportion of patients with ToF eligible for S-ICD, (ii) to identify the optimal sensing vector in ToF patients, (iii) to test specifically the eligibility for sICD with right-sided screening, and (iv) to compare with the proportion of eligible patients in a non-selected ICD population...
January 10, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28056014/prevalence-of-chagas-disease-in-a-u-s-population-of-latin-american-immigrants-with-conduction-abnormalities-on-electrocardiogram
#13
Mahmoud I Traina, Salvador Hernandez, Daniel R Sanchez, Jalal Dufani, Mohsin Salih, Adieb M Abuhamidah, Wilman Olmedo, Jason S Bradfield, Colin J Forsyth, Sheba K Meymandi
Chagas disease (CD) affects over six million people and is a leading cause of cardiomyopathy in Latin America. Given recent migration trends, there is a large population at risk in the United States (US). Early stage cardiac involvement from CD usually presents with conduction abnormalities on electrocardiogram (ECG) including right bundle branch block (RBBB), left anterior or posterior fascicular block (LAFB or LPFB, respectively), and rarely, left bundle branch block (LBBB). Identification of disease at this stage may lead to early treatment and potentially delay the progression to impaired systolic function...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28006108/digitoxin-for-airway-inflammation-in-cystic-fibrosis-preliminary-assessment-of-safety-pharmacokinetics-and-dose-finding
#14
Pamela L Zeitlin, Marie Diener-West, Karen A Callahan, Seakwoo Lee, C Conover Talbot, Bette Pollard, Michael P Boyle, Noah Lechtzin
RATIONALE: Cystic fibrosis (CF) lung disease progresses by a combination of airway inflammation, bacterial colonization, and infection. Airway inflammation is predominantly neutrophilic and complicates airway clearance therapies through cellular debris; excessive DNA; excessive and viscous mucus; and high concentrations of neutrophils, IL-8, and related cytokines liberated along the nuclear factor-κB signaling pathway. OBJECTIVES: We conducted a preliminary, single-site, randomized, double-blind, placebo-controlled study to evaluate the effects over 28 days of two dose levels (0...
February 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27995643/loperamide-trends-in-abuse-and-misuse-over-13-years-2002-2015
#15
Daniel R Lasoff, Cynthia H Koh, Bryan Corbett, Alicia B Minns, F Lee Cantrell
STUDY OBJECTIVE: With the increasing amount of information available on the Internet describing techniques for using loperamide either for self-treatment of opioid withdrawal syndromes or for recreational use (so-called legal highs), the objective was to describe a statewide poison control system's experience with loperamide misuse and abuse, with specific interest in cases of cardiotoxicity, and to determine if reported loperamide misuse or abuse cases have recently increased. DESIGN: Retrospective review...
December 20, 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27987028/left-ventricular-function-in-response-to-dipyridamole-stress-head-to-head-comparison-between-82-rubidium-pet-and-99m-tc-sestamibi-spect-ecg-gated-myocardial-perfusion-imaging
#16
Maria Clementina Giorgi, Jose Claudio Meneghetti, Jose Soares, Marisa Izaki, Andréa Falcão, Rodrigo Imada, William Chalela, Marco Antonio de Oliveira, Cesar Nomura, Hein J Verberne
PURPOSE: Myocardial perfusion imaging (MPI) with (99m)Tc-sestamibi (sestamibi) SPECT and rubidium-82 ((82)Rb) PET both allow for combined assessment of perfusion and left ventricular (LV) function. We sought to compare parameters of LV function obtained with both methods using a single dipyridamole stress dose. MATERIALS AND METHODS: A group of 221 consecutive patients (65.2 ± 10.4 years, 52.9% male) underwent consecutive sestamibi and (82)Rb MPI after a single dipyridamole stress dose...
December 16, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27966001/cortisol-brain-derived-neurotrophic-factor-ratio-associated-with-silent-ischaemia-in-a-black-male-cohort-the-sa-bpa-study
#17
Christiaan E Schutte, Leoné Malan, Jacobus D Scheepers, Woudri Oosthuizen, Marike Cockeran, Nicolaas T Malan
AIM: Emotional distress has been associated with cardiovascular disease (CVD) in Africans. Cortisol and brain-derived neurotrophic factor (BDNF), as markers of emotional distress, increase cardiometabolic risk. We therefore aimed to investigate associations between cardiometabolic risk markers and the cortisol-to-BDNF ratio (cortisol:BDNF). METHODS: A cross-sectional study included a bi-ethnic gender cohort (n = 406) aged 44.7 ± 9.52 years. Ambulatory blood pressure (ABPM), ECG, fasting serum cortisol and BDNF levels and cardiometabolic risk markers were obtained...
November 2016: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/27943311/fv-100-versus-valacyclovir-for-the-prevention-of-post-herpetic-neuralgia-and-the-treatment-of-acute-herpes-zoster-associated-pain-a-randomized-controlled-trial
#18
Stephen K Tyring, Patricia Lee, Gordon T Hill, Joel C Silverfield, Angela Yen Moore, Theresa Matkovits, John Sullivan-Bolyai
This prospective, parallel-group, randomized, double-blind, multicenter study compared the efficacy and safety of FV-100 with valacyclovir for reducing pain associated with acute herpes zoster (HZ). Patients, ≥50 years of age, diagnosed with HZ within 72 h of lesion appearance who had HZ-associated pain, were randomized 1:1:1 to a 7-day course of either FV-100 200 mg QD (n = 117), FV-100 400 mg QD (n = 116), or valacyclovir 1000 mg TID (n =117). Efficacy was evaluated on the basis of the burden of illness (BOI; Zoster Brief Pain Inventory scores); incidence and duration of clinically significant pain (CSP); pain scores; incidence and severity of post-herpetic neuralgia (PHN); and times to full lesion crusting and to lesion healing...
December 12, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27931004/increasing-trend-of-wearables-and-multimodal-interface-for-human-activity-monitoring-a-review
#19
REVIEW
Preeti Kumari, Lini Mathew, Poonam Syal
Activity recognition technology is one of the most important technologies for life-logging and for the care of elderly persons. Elderly people prefer to live in their own houses, within their own locality. If, they are capable to do so, several benefits can follow in terms of society and economy. However, living alone may have high risks. Wearable sensors have been developed to overcome these risks and these sensors are supposed to be ready for medical uses. It can help in monitoring the wellness of elderly persons living alone by unobtrusively monitoring their daily activities...
April 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27929709/safety-of-buprenorphine-transdermal-system-in-the-management-of-pain-in-older-adults
#20
COMPARATIVE STUDY
Joseph V Pergolizzi, Robert B Raffa, Zachary Marcum, Salvatore Colucci, Steven R Ripa
OBJECTIVES: To evaluate whether buprenorphine transdermal system (BTDS; Butrans®) is an option for the treatment of chronic pain in older adults. METHODS: This retrospective analysis of 16 placebo- and active-controlled and uncontrolled studies (N = 6566) evaluated the safety and tolerability profile in patients exposed to BTDS and compared the safety profiles associated with BTDS treatment in older patients ≥ 65 years of age (65 to 98 years) and younger patients < 65 years of age (18 to 64 years)...
January 2017: Postgraduate Medicine
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