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https://www.readbyqxmd.com/read/29040222/neurovascular-response-during-exercise-and-mental-stress-in-anabolic-steroid-users
#1
Rafael Armani Porello, Marcelo Rodrigues Dos Santos, Francis Ribeiro de Souza, Guilherme Wesley Peixoto da Fonseca, Ana Luiza Carrari Sayegh, Tiago Franco de Oliveira, César Abreu Akiho, Maurício Yonamine, Rosa Maria Rodrigues Pereira, Carlos Eduardo Negrão, Maria-Janieire de Nazaré Nunes Alves
PURPOSE: Increased resting muscle sympathetic nerve activity (MSNA) and lower forearm blood flow (FBF) were observed in young men who use anabolic androgenic steroids (AAS). However, the response of MSNA and FBF in AAS users triggered by muscle mechanoreflex and central command has never been tested. Additionally, we evaluated the blood pressure (BP) and heart rate (HR) responses during these maneuvers. METHODS: Nineteen AAS users (AASU) aged 31±6 yr and 18 AAS nonusers (AASNU) aged 29±4 yr were recruited...
October 16, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29039347/ferritin-as-a-potential-biomarker-of-efficacy-of-treatment-of-atrial-fibrillation-preliminary-report
#2
Adam Sokal, Sylwia Wójcik, Patrycja Pruszkowska, Oskar Kowalski, Radoslaw Lenarczyk, Agnieszka Liberska, Michał Mazurek, Slawomir Pluta, Zbigniew Kalarus
BACKGROUND: Complex mechanisms of responsible for originating and maintaining of atrial fibrillation (AF) are involved in pathophysiology of this arrhythmia. Inflammation substantially contribute to arrhythmic remodelling of atrial tissue.The aim of the present study is to assess an applicability of ferritin and high sensitive C-reactive protein (hs-CRP) as biomarkers of atrial fibrillation and their usefulness in evaluation of efficacy of cryoablation. MATERIALS AND METHODS: The study population consisted of 40 patients who underwent first AF cryoablation procedure...
October 13, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/29035100/serum-lipid-level-and-lifestyles-are-associated-with-carotid-femoral-pulse-wave-velocity-among-adults-4-4-year-prospectively-longitudinal-follow-up-of-a-clinical-trial
#3
XiaoXiao Zhao, Hongyu Wang, LiuJin Bo, Hongwei Zhao, Lihong Li, Yingyan Zhou
Lifestyle modifications are recommended as the initial treatment for high blood pressure. The influence of dyslipidemia might be via moderate arterial stiffness, which results in hypertension and cardiovascular disease. We used data from a subgroup of the lifestyle, level of serum lipids/carotid femoral-pulse wave velocity (CF-PWV) Susceptibility BEST Study, a population-based study of community-dwelling adults aged 45-75 years. The serum lipid level and CF-PWV were measured at baseline, and lifestyle such as smoking status, sleeping habits, and the level of oil or salt intake was determined with the use of a validated questionnaire during follow-up...
October 16, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29033166/early-peripheral-endothelial-dysfunction-predicts-myocardial-infarct-extension-and-microvascular-obstruction-in-patients-with-st-elevation-myocardial-infarction
#4
Sérgio Bravo Baptista, Mariana Faustino, Luís Brizida, José Loureiro, João Augusto, João Abecasis, Célia Monteiro, Paulo Leal, Maura Nédio, Pedro Farto E Abreu, Victor Gil, Carlos Morais
INTRODUCTION AND OBJECTIVES: The role of endothelial dysfunction (ED) in patients with ST-elevation myocardial infarction (STEMI) is poorly understood. Peripheral arterial tonometry (PAT) allows non-invasive evaluation of ED, but has never been used for this purpose early after primary percutaneous coronary intervention (P-PCI). Our purpose was to analyze the relation between ED assessed by PAT and both the presence of microvascular obstruction (MVO) and infarct extension in STEMI patients...
October 12, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29029934/ability-of-pulse-wave-transit-time-to-detect-changes-in-stroke-volume-and-to-estimate-cardiac-output-compared-to-thermodilution-technique-in-isoflurane-anaesthetised-dogs
#5
H Sano, J P Chambers
OBJECTIVE: To evaluate the ability of pulse wave transit time (PWTT) to detect changes in stroke volume (SV) and to estimate cardiac output (CO) compared with the thermodilution technique in isoflurane-anaesthetized dogs. STUDY DESIGN: Prospective, experimental study. ANIMALS: Eight adult laboratory dogs. METHODS: The dogs were anaesthetized with isoflurane and mechanically ventilated. Reference CO (TDCO) was measured via a pulmonary artery catheter using the thermodilution technique and reference SV (TDSV) was calculated...
April 26, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29021273/improvement-in-care-and-outcomes-for-emergency-medical-service-transported-patients-with-st-elevation-myocardial-infarction-stemi-with-and-without-prehospital-cardiac-arrest-a-mission-lifeline-stemi-accelerator-study
#6
Kristian Kragholm, Di Lu, Karen Chiswell, Hussein R Al-Khalidi, Mayme L Roettig, Matthew Roe, James Jollis, Christopher B Granger
BACKGROUND: Patients with ST-elevation myocardial infarction (STEMI) with out-of-hospital cardiac arrest (OHCA) may benefit from direct transport to a percutaneous cardiac intervention (PCI) hospital but have previously been less likely to bypass local non-PCI hospitals to go to a PCI center. METHODS AND RESULTS: We reported time trends in emergency medical service transport and care of patients with STEMI with and without OHCA included from 171 PCI-capable hospitals in 16 US regions with participation in the Mission: Lifeline STEMI Accelerator program between July 1, 2012, and March 31, 2014...
October 11, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28984702/current-assessment-of-heart-rate-variability-and-qtc-interval-length-in-hiv-aids
#7
Roger C McIntosh, Judith D Lobo, Barry E Hurwitz
PURPOSE OF REVIEW: The increasing prevalence of cardiovascular disease comorbidity in persons infected with the HIV has become a global concern. The electrocardiogram (ECG) is increasingly being utilized to provide clinically relevant information regarding cardiac arrhythmias and cardio-autonomic dysfunction. The purpose of this review is to summarize the latest research comparing QT and R-to-R interval length as a function of HIV+ status or antiretroviral therapy (ART) regimen. RECENT FINDINGS: Prolongation of the corrected QTc interval may be acquired in HIV+ ART-naive individuals, exacerbated by various classes of ART drugs, and is generally predictive of lethal cardiac arrhythmias, with effects observed from childhood to adulthood...
November 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28980294/the-effect-of-intravenous-n-acetylcysteine-on-prevention-of-atrial-fibrillation-after-coronary-artery-bypass-graft-surgery-a-double-blind-randomized-placebo-controlled-trial
#8
Aria Soleimani, Mohammad Reza Habibi, Farshad Hasanzadeh Kiabi, Abbas Alipour, Valiollah Habibi, Soheil Azizi, Amir Emami Zeydi, Fatemeh Bozorg Sohrabi
BACKGROUND: Atrial fibrillation (AF) is one of the most frequently occurring dysrhythmias after coronary artery bypass graft (CABG) surgery. AIM: The aim of this study was to evaluate the effect of intravenous N-acetylcysteine (NAC) on the prevention of AF after CABG surgery. METHODS: In a double-blind, randomized controlled trial, a total of 150 patients who were scheduled for on-pump CABG surgery were randomly assigned into two groups. In group A, patients received an intravenous NAC infusion (50 mg/kg) after induction of anesthesia...
October 5, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28964591/a-double-blind-randomized-placebo-controlled-clinical-study-of-trofinetide-in-the-treatment-of-rett-syndrome
#9
Daniel G Glaze, Jeffrey L Neul, Alan Percy, Tim Feyma, Arthur Beisang, Alex Yaroshinsky, George Stoms, David Zuchero, Joseph Horrigan, Larry Glass, Nancy E Jones
BACKGROUND: This study aimed to determine the safety and tolerability of trofinetide and to evaluate efficacy measures in adolescent and adult females with Rett syndrome, a serious and debilitating neurodevelopmental condition for which no therapies are available for its core features. METHODS: This was an exploratory, phase 2, multicenter, double-blind, placebo-controlled, dose-escalation study of the safety and tolerability of trofinetide in 56 adolescent and adult females with Rett syndrome...
July 8, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28954073/association-of-caspase-1-polymorphisms-with-chagas-cardiomyopathy-among-individuals-in-santa-cruz-bolivia
#10
Katherine Yih-Jia Fu, Roxana Zamudio, Jo Henderson-Frost, Alex Almuedo, Hannah Steinberg, Steven Joseph Clipman, Gustavo Duran, Rachel Marcus, Thomas Crawford, Daniel Alyesh, Rony Colanzi, Jorge Flores, Robert Hugh Gilman, Caryn Bern
INTRODUCTION: Trypanosoma cruzi (Tc) infection is usually acquired in childhood in endemic areas, leading to Chagas disease, which progresses to Chagas cardiomyopathy in 20-30% of infected individuals over decades. The pathogenesis of Chagas cardiomyopathy involves the host inflammatory response to T. cruzi, in which upstream caspase-1 activation prompts the cascade of inflammatory chemokines/cytokines, cardiac remodeling, and myocardial dysfunction. The aim of the present study was to examine the association of two caspase-1 single nucleotide polymorphisms (SNPs) with cardiomyopathy...
July 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28932359/coronary-angiography-findings-in-cardiac-arrest-patients-with-non-diagnostic-post-resuscitation-electrocardiogram-a-comparison-of-shockable-and-non-shockable-initial-rhythms
#11
Pedro Martínez-Losas, Pablo Salinas, Carlos Ferrera, María Teresa Nogales-Romo, Francisco Noriega, María Del Trigo, Iván Javier Núñez-Gil, Luis Nombela-Franco, Nieves Gonzalo, Pilar Jiménez-Quevedo, Javier Escaned, Antonio Fernández-Ortiz, Carlos Macaya, Ana Viana-Tejedor
AIM: To investigate the impact of coronary artery disease in a cohort of patients resuscitated from cardiac arrest with non-diagnostic electrocardiogram. METHODS: From March 2004 to February 2016, 203 consecutive patients resuscitated from in or out-of-hospital sudden cardiac arrest and non-diagnostic post-resuscitation electrocardiogram (defined as ST segment elevation or pre-sumably new left bundle branch block) who underwent invasive coronary angiogram during hospitalization were included...
August 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28912840/the-relationship-between-insulin-sensitivity-and-heart-rate-corrected-qt-interval-in-patients-with-type-2-diabetes
#12
Xiao-Hua Yang, Jian-Bin Su, Xiu-Lin Zhang, Li-Hua Zhao, Feng Xu, Xue-Qin Wang, Xing-Bo Cheng
BACKGROUND: Reduced insulin sensitivity not only contributes to the pathogenesis of type 2 diabetes but is also linked to multiple metabolic risk factors and cardiovascular diseases (CVD). A prolonged heart rate-corrected QT interval (QTc interval) is related to ventricular arrhythmias and CVD mortality and exhibits a high prevalence among type 2 diabetes patients. The aim of the study was to investigate the relationship between insulin sensitivity and the QTc interval in patients with type 2 diabetes...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28892227/dynamic-changes-of-qtc-interval-and-prognostic-significance-in-takotsubo-stress-cardiomyopathy
#13
Francesco Santoro, Natale Daniele Brunetti, Nicola Tarantino, Jorge Romero, Francesca Guastafierro, Armando Ferraretti, Luigi F M Di Martino, Riccardo Ieva, Pier Luigi Pellegrino, Matteo Di Biase, Luigi Di Biase
BACKGROUND: Prolonged QT corrected (QTc) intervals are associated with adverse cardiovascular outcomes both in healthy and high-risk populations. Our objective was to evaluate the QTc intervals during a takotsubo cardiomyopathy (TTC) episodes and their potential prognostic role. HYPOTHESIS: Dynamic changes of QTc interval during hospitalization for TTC could be associated with outcome at follow-up. METHODS: Fifty-two consecutive patients hospitalized for TTC were enrolled...
September 11, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28888406/temporal-trends-in-the-prevalence-severity-and-localization-of-myocardial-ischemia-and-necrosis-at-myocardial-perfusion-imaging-after-myocardial-infarction
#14
MULTICENTER STUDY
Francesco Nudi, Orazio Schillaci, Natale Di Belardino, Francesco Versaci, Fabrizio Tomai, Annamaria Pinto, Giandomenico Neri, Enrica Procaccini, Alessandro Nudi, Giacomo Frati, Giuseppe Biondi-Zoccai
The definition, presentation, and management of myocardial infarction (MI) have changed substantially in the last decade. Whether these changes have impacted on the presence, severity, and localization of necrosis at myocardial perfusion imaging (MPI) has not been appraised to date. Subjects undergoing MPI and reporting a history of clinical MI were shortlisted. We focused on the presence, severity, and localization of necrosis at MPI with a retrospective single-center analysis. A total of 10,476 patients were included, distinguishing 5 groups according to the period in which myocardial perfusion scintigraphy had been performed (2004 to 2005, 2006 to 2007, 2008 to 2009, 2010 to 2011, 2012 to 2013)...
October 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28886483/a-window-based-time-series-feature-extraction-method
#15
Deniz Katircioglu-Öztürk, H Altay Güvenir, Ursula Ravens, Nazife Baykal
This study proposes a robust similarity score-based time series feature extraction method that is termed as Window-based Time series Feature ExtraCtion (WTC). Specifically, WTC generates domain-interpretable results and involves significantly low computational complexity thereby rendering itself useful for densely sampled and populated time series datasets. In this study, WTC is applied to a proprietary action potential (AP) time series dataset on human cardiomyocytes and three precordial leads from a publicly available electrocardiogram (ECG) dataset...
August 9, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28869925/cadmium-stress-assessment-based-on-the-electrocardiogram-characteristics-of-zebra-fish-danio-rerio-qrs-complex-could-play-an-important-role
#16
Na Xing, Lizhen Ji, Jie Song, Jingchun Ma, Shangge Li, Zongming Ren, Fei Xu, Jianping Zhu
The electrocardiogram (ECG) of zebra fish (Danio rerio) expresses cardiac features that are similar to humans. Here we use sharp microelectrode measurements to obtain ECG characteristics in adult zebra fish and analyze the effects of cadmium chloride (CdCl2) on the heart. We observe the overall changes of ECG parameters in different treatments (0.1 TU, 0.5 TU and 1.0 TU CdCl2), including P wave, Q wave, R wave, S wave, T wave, PR interval (atrial contraction), QRS complex (ventricular depolarization), ST segment, and QT interval (ventricular repolarization)...
August 31, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28841028/clinical-impact-and-predictors-of-complete-st-segment-resolution-after-primary-percutaneous-coronary-intervention-a-subanalysis-of-the-atlantic-trial
#17
Enrico Fabris, Arnoud van 't Hof, Christian W Hamm, Frédéric Lapostolle, Jens F Lassen, Shaun G Goodman, Jurriën M Ten Berg, Leonardo Bolognese, Angel Cequier, Mohamed Chettibi, Christopher J Hammett, Kurt Huber, Magnus Janzon, Béla Merkely, Robert F Storey, Uwe Zeymer, Warren J Cantor, Anne Tsatsaris, Mathieu Kerneis, Abdourahmane Diallo, Eric Vicaut, Gilles Montalescot
BACKGROUND: In the ATLANTIC (Administration of Ticagrelor in the catheterization laboratory or in the Ambulance for New ST elevation myocardial Infarction to open the Coronary artery) trial the early use of aspirin, anticoagulation, and ticagrelor coupled with very short medical contact-to-balloon times represent good indicators of optimal treatment of ST-elevation myocardial infarction and an ideal setting to explore which factors may influence coronary reperfusion beyond a well-established pre-hospital system...
August 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28808886/assessment-of-pharmacokinetic-interactions-between-obeticholic-acid-and-caffeine-midazolam-warfarin-dextromethorphan-omeprazole-rosuvastatin-and-digoxin-in-phase-1-studies-in-healthy-subjects
#18
Jeffrey E Edwards, Lise Eliot, Andrew Parkinson, Sharon Karan, Leigh MacConell
INTRODUCTION: Obeticholic acid (OCA), a potent and selective farnesoid X receptor agonist, is indicated for the treatment of primary biliary cholangitis (PBC). We investigated the potential drug-drug interaction effect of OCA on metabolic CYP450 enzymes and drug transporters. METHODS: Five phase 1 single-center, open-label, fixed-sequence, inpatient studies were conducted in healthy adult subjects to evaluate the effect of oral daily doses of 10 or 25 mg OCA on single-dose plasma pharmacokinetics of specific probe substrates for enzymes CYP1A2 (caffeine, R-warfarin), CYP3A (midazolam, R-warfarin), CYP2C9 (S-warfarin), CYP2D6 (dextromethorphan), CYP2C19 (omeprazole), and drug transporters, BCRP/OATP1B1/OATP1B3 (rosuvastatin), and P-gp (digoxin)...
August 14, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28808846/age-related-changes-in-morphology-of-left-atrial-appendage-in-patients-with-atrial-fibrillation
#19
Yukina Hirata, Kenya Kusunose, Hirotsugu Yamada, Rikuto Shimizu, Yuta Torii, Susumu Nishio, Yoshihito Saijo, Shoichiro Takao, Takeshi Soeki, Masataka Sata
The purpose of this study was to evaluate the relationship between age and frequency of left atrial appendage (LAA) morphology in patients with atrial fibrillation (AF) compared with sinus rhythm (SR). We enrolled 145 AF patients, and 199 SR patients for the control group without any cardiovascular disease. LAA volume index (LAAVi) and morphology were assessed by electrocardiogram-gated computed tomography angiography. LAA morphology was classified into "chicken wing" or "non-chicken wing" according to the previously described classification...
August 14, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28752472/technical-challenges-related-to-implementation-of-a-formula-one-real-time-data-acquisition-and-analysis-system-in-a-paediatric-intensive-care-unit
#20
B Rajeswari Matam, Heather Duncan
Most existing, expert monitoring systems do not provide the real time continuous analysis of the monitored physiological data that is necessary to detect transient or combined vital sign indicators nor do they provide long term storage of the data for retrospective analyses. In this paper we examine the feasibility of implementing a long term data storage system which has the ability to incorporate real-time data analytics, the system design, report the main technical issues encountered, the solutions implemented and the statistics of the data recorded...
July 27, 2017: Journal of Clinical Monitoring and Computing
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