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https://www.readbyqxmd.com/read/28398490/the-prognostic-benefit-of-cardiac-resynchronization-therapy-is-greater-in-concordant-vs-discordant-left-bundle-branch-block-in-the-multicenter-automatic-defibrillator-implantation-trial-cardiac-resynchronization-therapy-madit-crt
#1
Luigi Padeletti, Alberto Aimo, Bella Vishenvsky, Arielle Schwartz, Scott McNitt, Paul J Wang, Arthur J Moss, Michele Emdin, Wojciech Zareba
Aims: Discordant and concordant left bundle branch block (dLBBB/cLBBB) are characterized by negative or positive T waves, respectively, in lateral leads. We assessed if the two morphologies are associated with different clinical status and prognosis in patients with heart failure (HF) and current indication to Cardiac Resynchronization Therapy (CRT)/CRT-Defibrillator (CRT-D). Methods and results: Baseline electrocardiograms of 1270 patients with LBBB in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy cohort were analysed to identify dLBBB and cLBBB...
April 7, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28394409/evaluation-of-qtc-in-rett-syndrome-correlation-with-age-severity-and-genotype
#2
Jane Crosson, Siddharth Srivastava, Genila M Bibat, Siddharth Gupta, Aditi Kantipuly, Constance Smith-Hicks, Scott M Myers, Abanti Sanyal, Gayane Yenokyan, Joel Brenner, Sakkubai R Naidu
Rett syndrome (RTT) is caused by MECP2 mutations, resulting in various neurological symptoms. Prolonged corrected QT interval (QTc) is also reported and is a speculated cause of sudden death in RTT. The purpose of this study was to correlate QTc in RTT patients with age, clinical severity, and genotype. 100 RTT patients (98 females, 2 males) with MECP2 mutations underwent baseline neurological evaluation (KKI-RTT Severity Scale) and QTc measurement (standard 12 lead electrocardiogram) as part of our prospective natural history study...
April 10, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28393707/relationship-of-high-sensitivity-c-reactive-protein-concentrations-and-systolic-heart-failure
#3
Sheng Kang, Lie-Ying Fan, Ming Chen, Jue Li, Zhong-Min Liu
Objective Excessive activated proinflammatory cytokines may promote extracellular matrix alterations which induce adverse left ventricular remodeling in systolic heart failure (SHF). We sought to identify whether high-sensitivity C-reactive protein (hsCRP) levels were independently associated with SHF. Methods In our retrospective case-control study, 2236 subjects were included, and 260 patients had SHF. Blood sample collection, clinical laboratory tests, electrocardiogram and echocardiography examinations were performed...
April 4, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28390723/manipulation-of-reproductive-seasonality-using-melatonin-implantation-in-anglo-nubian-does-treated-with-controlled-internal-drug-release-and-equine-chorionic-gonadotropin-during-the-nonbreeding-season
#4
M Y El-Mokadem, A N M Nour El-Din, T A Ramadan, A M A Rashad, T A Taha, M A Samak
The objective of this study was to compare the efficiency of hormonal treatments on ovarian activity and reproductive performance in anestrous Anglo-Nubian does during the nonbreeding season (February to May). A total of 48 multiparous does were divided into 2 groups (24 lactating does and 24 dry does). In each group, animals were allocated randomly into 2 equal subgroups (12 does each). In the first subgroup, does received a single 18-mg melatonin implant for 42 d followed by a controlled internal drug release (CIDR) device for 19 d in conjunction with 500 IU of equine chorionic gonadotropin (eCG) i...
April 5, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28356306/effect-of-age-and-sex-on-the-qtc-interval-in-children-and-adolescents-with-type-1-and-2-long-qt-syndrome
#5
Arja S Vink, Sally-Ann B Clur, Ronald B Geskus, Andreas C Blank, Charlotte C A De Kezel, Masao Yoshinaga, Nynke Hofman, Arthur A M Wilde, Nico A Blom
BACKGROUND: In congenital long-QT syndrome, age, sex, and genotype have been associated with cardiac events, but their effect on the trend in QTc interval has never been established. We, therefore, aimed to assess the effect of age and sex on the QTc interval in children and adolescents with type 1 (LQT1) and type 2 (LQT2) long-QT syndrome. METHODS AND RESULTS: QTc intervals of 12-lead resting electrocardiograms were determined, and trends over time were analyzed using a linear mixed-effects model...
April 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28350812/sports-related-sudden-cardiac-deaths-in-the-young-population-of-switzerland
#6
Babken Asatryan, Cristina Vital, Christoph Kellerhals, Argelia Medeiros-Domingo, Christoph Gräni, Lukas D Trachsel, Christian M Schmied, Ardan M Saguner, Prisca Eser, David Herzig, Stephan Bolliger, Katarzyna Michaud, Matthias Wilhelm
BACKGROUND: In Switzerland, ECG screening was first recommended for national squad athletes in 1998. Since 2001 it has become mandatory in selected high-risk professional sports. Its impact on the rates of sports-related sudden cardiac death (SCD) is unknown. OBJECTIVE: We aimed to study the incidence, causes and time trends of sports-related SCD in comparison to SCD unrelated to exercise in Switzerland. METHODS: We reviewed all forensic reports of SCDs of the German-speaking region of Switzerland in the age group of 10 to 39 years, occurring between 1999 and 2010...
2017: PloS One
https://www.readbyqxmd.com/read/28348152/pharmacokinetics-and-tolerance-of-the-phage-endolysin-based-candidate-drug-sal200-after-a-single-intravenous-administration-among-healthy-volunteers
#7
Soo Youn Jun, In Jin Jang, Seonghae Yoon, Kyungho Jang, Kyung-Sang Yu, Joo Youn Cho, Moon-Woo Seong, Gi Mo Jung, Seong Jun Yoon, Sang Hyeon Kang
This study is a phase 1, single-center, randomized, double-blind, placebo-controlled, single-dosing, and dose-escalating study of intravenous SAL200. It is a new candidate drug for antibiotic-resistant staphylococcal infections based on a recombinant form of the phage endolysin SAL-1. The study evaluated the pharmacokinetics, pharmacodynamics, and tolerance among healthy male volunteers after the intravenous infusion of single ascending doses of SAL200 (0.1, 0.3, 1, 3, and 10 mg/kg).SAL200 was well tolerated, and no serious adverse events (AEs) were observed in this clinical study...
March 27, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28340861/a-randomised-double-blind-placebo-controlled-long-term-extension-study-of-the-efficacy-safety-and-tolerability-of-fixed-dose-combinations-of-aclidinium-formoterol-or-monotherapy-in-the-treatment-of-chronic-obstructive-pulmonary-disease
#8
Anthony D'Urzo, Stephen Rennard, Edward Kerwin, James F Donohue, Alejhandra Lei, Eduard Molins, Anne Leselbaum
INTRODUCTION: Aclidinium bromide/formoterol fumarate (AB/FF) 400/12 μg efficacy and safety was demonstrated in two 6-month Phase III studies (AUGMENT and ACLIFORM) and a 12-month study in patients with moderate to severe chronic obstructive pulmonary disease (COPD). This Phase III, double-blind, placebo-controlled, 6-month AUGMENT extension investigated the long-term safety and tolerability of AB/FF 400/12 μg (NCT01572792). METHODS: Patients were randomised in AUGMENT (1:1:1:1:1) to twice-daily AB/FF 400/12 μg, AB/FF 400/6 μg, AB 400 μg, FF 12 μg or placebo...
April 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28288885/patients-with-ruptured-abdominal-aortic-aneurysm-have-become-higher-risk
#9
Anoosha Aslam, Charles M Fisher, Cathy Thoo, Michael L Neale, Shannon D Thomas
BACKGROUND: Independent risk factors such as age, loss of consciousness, elevated serum creatinine, low hemoglobin, and electrocardiogram evidence of ischemia have previously been shown to predict mortality after ruptured abdominal aortic aneurysm (rAAA). With an aging Australian population, we sought to determine if patients presenting with rAAA now had more predictive risk factors for mortality and whether these factors remain predictive of mortality. METHODS: The records of all patients presenting with rAAA between January 1985 to December 1993 (past era, group 1) and January 2007 to December 2011 (modern era, group 2) were retrieved...
March 11, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28278167/superior-success-rate-of-intracavitary-electrocardiogram-guidance-for-peripherally-inserted-central-catheter-placement-in-patients-with-cancer-a-randomized-open-label-controlled-multicenter-study
#10
Ling Yuan, Rongmei Li, Aifeng Meng, Yuling Feng, Xiancui Wu, Yiqun Yang, Ping Chen, Zhenzhu Qiu, Jing Qi, Chuanying Chen, Jia Wei, Minyi Qin, Weiwei Kong, Xiangyu Chen, Wei Xu
BACKGROUND: Intracavitary electrocardiogram (IC ECG) guidance emerges as a new technique for peripherally inserted central catheters (PICCs) placement and demonstrates many potential advantages in recent observational studies. AIMS: To determine whether IC ECG-guided PICCs provide more accurate positioning of catheter tips compared to conventional anatomical landmarks in patients with cancer undergoing chemotherapy. METHODS: In this multicenter, open-label, randomized controlled study (ClinicalTrials...
2017: PloS One
https://www.readbyqxmd.com/read/28268405/wearable-ecg-platform-for-continuous-cardiac-monitoring
#11
S P Preejith, R Dhinesh, Jayaraj Joseph, Mohanasankar Sivaprakasam
An ultra-low power ECG platform for continuous and minimally intrusive monitoring for systems with minimal processing capabilities, is presented in this paper. The platform is capable of detecting abnormalities in the ECG signal by extracting and analyzing features related to various cardiac trends. The platform is built to continuously operate on any of the 12 leads and the presented work includes a single lead implementation that works on lead I or II. A single lead, wearable ECG patch that can detect rhythm based arrhythmias and continuously monitor beat-to-beat heart rate and respiratory rate has been developed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268310/towards-24-7-continuous-heart-rate-monitoring
#12
Adrian Tarniceriu, Jakub Parak, Philippe Renevey, Marko Nurmi, Mattia Bertschi, Ricard Delgado-Gonzalo, Ilkka Korhonen
Heart rate (HR) and HR variability (HRV) carry rich information about physical activity, mental and physical load, physiological status, and health of an individual. When combined with activity monitoring and personalized physiological modelling, HR/HRV monitoring may be used for monitoring of complex behaviors and impact of behaviors and external factors on the current physiological status of an individual. Optical HR monitoring (OHR) from wrist provides a comfortable and unobtrusive method for HR/HRV monitoring and is better adhered by users than traditional ECG electrodes or chest straps...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28251667/a-comparison-of-the-pharmacokinetics-and-safety-of-enzalutamide-in-subjects-with-hepatic-impairment-and-matched-healthy-subjects
#13
W Krauwinkel, J Noukens, J van Dijk, S Popa, T Ouatas, M de Vries, D Phung, J Gibbons, J Mordenti, L Mateva
WHAT IS KNOWN AND OBJECTIVE: Enzalutamide is an androgen receptor inhibitor approved for treatment of metastatic castration-resistant prostate cancer. Enzalutamide is highly protein bound and eliminated primarily by hepatic metabolism; therefore, it is important to understand whether enzalutamide pharmacokinetics is altered by hepatic impairment. METHODS: Pharmacokinetic data were obtained from two non-randomized, open-label, single-dose, phase 1 studies conducted in patients with mild (Child-Pugh class A, n = 6) or moderate (Child-Pugh class B, n = 8) hepatic impairment (NCT01901133) or severe (Child-Pugh class C, n = 8) hepatic impairment (NCT02138162) and their corresponding matched healthy controls; data from both studies are presented here...
March 1, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28248005/evaluation-of-the-ecg-based-selvester-scoring-method-to-estimate-myocardial-scar-burden-and-predict-clinical-outcome-in-patients-with-left-bundle-branch-block-with-comparison-to-late-gadolinium-enhancement-cmr-imaging
#14
Uzma Chaudhry, Pyotr G Platonov, Robert Jablonowski, Jean-Philippe Couderc, Henrik Engblom, Xiajuang Xia, Björn Wieslander, Brett D Atwater, David G Strauss, Jesper Van der Pals, Martin Ugander, Marcus Carlsson, Rasmus Borgquist
BACKGROUND: Myocardial scar burden quantification is an emerging clinical parameter for risk stratification of sudden cardiac death and prediction of ventricular arrhythmias in patients with left ventricular dysfunction. We investigated the relationships among semiautomated Selvester score burden and late gadolinium enhancement-cardiovascular magnetic resonance (LGE-CMR) assessed scar burden and clinical outcome in patients with underlying heart failure, left bundle branch block (LBBB) and implantable cardioverter-defibrillator (ICD) treatment...
March 1, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28226575/wearable-ecg-platform-for-continuous-cardiac-monitoring
#15
S P Preejith, R Dhinesh, Jayaraj Joseph, Mohanasankar Sivaprakasam, S P Preejith, R Dhinesh, Jayaraj Joseph, Mohanasankar Sivaprakasam, R Dhinesh, Mohanasankar Sivaprakasam, S P Preejith, Jayaraj Joseph
An ultra-low power ECG platform for continuous and minimally intrusive monitoring for systems with minimal processing capabilities, is presented in this paper. The platform is capable of detecting abnormalities in the ECG signal by extracting and analyzing features related to various cardiac trends. The platform is built to continuously operate on any of the 12 leads and the presented work includes a single lead implementation that works on lead I or II. A single lead, wearable ECG patch that can detect rhythm based arrhythmias and continuously monitor beat-to-beat heart rate and respiratory rate has been developed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226469/towards-24-7-continuous-heart-rate-monitoring
#16
Adrian Tarniceriu, Jakub Parak, Philippe Renevey, Marko Nurmi, Mattia Bertschi, Ricard Delgado-Gonzalo, Ilkka Korhonen, Adrian Tarniceriu, Jakub Parak, Philippe Renevey, Marko Nurmi, Mattia Bertschi, Ricard Delgado-Gonzalo, Ilkka Korhonen, Jakub Parak, Ricard Delgado-Gonzalo, Adrian Tarniceriu, Philippe Renevey, Marko Nurmi, Mattia Bertschi, Ilkka Korhonen
Heart rate (HR) and HR variability (HRV) carry rich information about physical activity, mental and physical load, physiological status, and health of an individual. When combined with activity monitoring and personalized physiological modelling, HR/HRV monitoring may be used for monitoring of complex behaviors and impact of behaviors and external factors on the current physiological status of an individual. Optical HR monitoring (OHR) from wrist provides a comfortable and unobtrusive method for HR/HRV monitoring and is better adhered by users than traditional ECG electrodes or chest straps...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224924/left-bundle-branch-block-in-patients-with-acute-myocardial-infarction-presentation-treatment-and-trends-in-outcome-from-1997-to-2016-in-routine-clinical-practice
#17
Paul Erne, Juan F Iglesias, Philip Urban, Franz R Eberli, Hans Rickli, René Simon, Thomas A Fischer, Dragana Radovanovic
BACKGROUND: Whether patients with acute myocardial infarction presenting with new or presumed new left bundle-branch block (LBBB) should be treated in the same way as those presenting with ST-elevation (STE) is still a matter of debate. METHODS: Data from 28,358 patients enrolled in AMIS Plus from 1997 to 2016 were analyzed to evaluate differences in treatment and outcome of patients presenting with LBBB (n=2295) or STE (n=26,090) on their initial electrocardiogram using descriptive statistics and multivariate logistic regression...
February 2017: American Heart Journal
https://www.readbyqxmd.com/read/28213055/electrophysiological-measurements-that-can-explain-and-guide-temporary-accelerated-pacing-to-avert-re-occurrence-of-torsade-de-pointes-arrhythmias-in-the-canine-chronic-atrioventricular-block-model
#18
Sofieke C Wijers, Alexandre Bossu, Albert Dunnink, Jet D M Beekman, Rosanne Varkevisser, Alfonso Aranda Hernández, Mathias Meine, Marc A Vos
BACKGROUND: Pacing at higher rates is known to suppress torsade de pointes (TdP) arrhythmias. Nevertheless, exact application and mechanism need further clarification. In the anesthetized canine chronic atrioventricular block model, ventricular remodeling is responsible for a high and reproducible incidence of TdP upon a challenge with dofetilide. OBJECTIVE: We used this model to investigate by what mechanism accelerated pacing averts TdP and what repolarization parameter could be used to guide temporary accelerated pacing (TAP)...
May 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28211883/the-inflammatory-state-provokes-sexual-dimorphism-in-left-ventricular-and-electrocardiographic-effects-of-chronic-cyclosporine-in-rats
#19
Hany M El-Bassossy, Zainy M Banjar, Mahmoud M El-Mas
Although cardiotoxicity has been recognized as an adverse effect of cyclosporine A (CSA), no information exists regarding sex specificity of CSA cardiotoxicity. We tested the hypothesis that left ventricular (LV) and electrocardiographic (ECG) effects of CSA and related inflammatory/histopathological derangements are sex related. CSA reduced the LV slope of end-systolic pressure volume relationship and increased isovolumic relaxation constant. These effects were more pronounced in male compared to female rats, suggesting LV systolic and diastolic dysfunction...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28194254/long-term-continuous-ambulatory-ecg-monitors-and-external-cardiac-loop-recorders-for-cardiac-arrhythmia-a-health-technology-assessment
#20
REVIEW
(no author information available yet)
BACKGROUND: Ambulatory electrocardiography (ECG) monitors are often used to detect cardiac arrhythmia. For patients with symptoms, an external cardiac loop recorder will often be recommended. The improved recording capacity of newer Holter monitors and similar devices, collectively known as longterm continuous ambulatory ECG monitors, suggests that they will perform just as well as, or better than, external loop recorders. This health technology assessment aimed to evaluate the effectiveness, cost-effectiveness, and budget impact of longterm continuous ECG monitors compared with external loop recorders in detecting symptoms of cardiac arrhythmia...
2017: Ontario Health Technology Assessment Series
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