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Resting state functional connectivity psychiatry

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https://www.readbyqxmd.com/read/27784534/toward-understanding-thalamocortical-dysfunction-in-schizophrenia-through-computational-models-of-neural-circuit-dynamics
#1
REVIEW
John D Murray, Alan Anticevic
The thalamus is implicated in the neuropathology of schizophrenia, and multiple modalities of noninvasive neuroimaging provide converging evidence for altered thalamocortical dynamics in the disorder, such as functional connectivity and oscillatory power. However, it remains a challenge to link these neuroimaging biomarkers to underlying neural circuit mechanisms. One potential path forward is a "Computational Psychiatry" approach that leverages computational models of neural circuits to make predictions for the dynamical impact dynamical impact on specific thalamic disruptions hypothesized to occur in the pathophysiology of schizophrenia...
October 23, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27090303/intrinsic-functional-connectivity-in-late-life-depression-trajectories-over-the-course-of-pharmacotherapy-in-remitters-and-non-remitters
#2
H T Karim, C Andreescu, D Tudorascu, S F Smagula, M A Butters, J F Karp, C Reynolds, H J Aizenstein
Previous studies in late-life depression (LLD) have found that patients have altered intrinsic functional connectivity in the dorsal default mode network (DMN) and executive control network (ECN). We aimed to detect connectivity differences across a treatment trial among LLD patients as a function of remission status. LLD patients (N=37) were enrolled into a 12-week trial of venlafaxine and underwent five functional magnetic resonance imaging resting state scans during treatment. Patients had no history of drug abuse, psychosis, dementia/neurodegenerative diseases or medical conditions with known effects on mood...
April 19, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/26901357/personalized-medicine-review-and-perspectives-of-promising-baseline-eeg-biomarkers-in-major-depressive-disorder-and-attention-deficit-hyperactivity-disorder
#3
Sebastian Olbrich, Rik van Dinteren, Martijn Arns
Personalized medicine in psychiatry is in need of biomarkers that resemble central nervous system function at the level of neuronal activity. Electroencephalography (EEG) during sleep or resting-state conditions and event-related potentials (ERPs) have not only been used to discriminate patients from healthy subjects, but also for the prediction of treatment outcome in various psychiatric diseases, yielding information about tailored therapy approaches for an individual. This review focuses on baseline EEG markers for two psychiatric conditions, namely major depressive disorder and attention deficit hyperactivity disorder...
2015: Neuropsychobiology
https://www.readbyqxmd.com/read/26888415/distinct-neurobiological-signatures-of-brain-connectivity-in-depression-subtypes-during-natural-viewing-of-emotionally-salient-films
#4
C C Guo, M P Hyett, V T Nguyen, G B Parker, M J Breakspear
BACKGROUND: Establishing an evidence-based diagnostic system informed by the biological (dys)function of the nervous system is a major priority in psychiatry. This objective, however, is often challenged by difficulties in identifying homogeneous clinical populations. Melancholia, a biological and endogenous subtype for major depressive disorder, presents a canonical test case in the search of biological nosology. METHOD: We employed a unique combination of naturalistic functional magnetic resonance imaging (fMRI) paradigms - resting state and free viewing of emotionally salient films - to search for neurobiological signatures of depression subtypes...
May 2016: Psychological Medicine
https://www.readbyqxmd.com/read/26830141/midbrain-functional-connectivity-and-ventral-striatal-dopamine-d2-type-receptors-link-to-impulsivity-in-methamphetamine-users
#5
M Kohno, K Okita, A M Morales, C L Robertson, A C Dean, D G Ghahremani, F W Sabb, R A Rawson, M A Mandelkern, R M Bilder, E D London
Stimulant use disorders are associated with deficits in striatal dopamine receptor availability, abnormalities in mesocorticolimbic resting-state functional connectivity (RSFC) and impulsivity. In methamphetamine-dependent research participants, impulsivity is correlated negatively with striatal D2-type receptor availability, and mesocorticolimbic RSFC is stronger than that in controls. The extent to which these features of methamphetamine dependence are interrelated, however, is unknown. This question was addressed in two studies...
February 2, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/26552591/inflammation-is-associated-with-decreased-functional-connectivity-within-corticostriatal-reward-circuitry-in-depression
#6
J C Felger, Z Li, E Haroon, B J Woolwine, M Y Jung, X Hu, A H Miller
Depression is associated with alterations in corticostriatal reward circuitry. One pathophysiological pathway that may drive these changes is inflammation. Biomarkers of inflammation (for example, cytokines and C-reactive protein (CRP)) are reliably elevated in depressed patients. Moreover, administration of inflammatory stimuli reduces neural activity and dopamine release in reward-related brain regions in association with reduced motivation and anhedonia. Accordingly, we examined whether increased inflammation in depression affects corticostriatal reward circuitry to lead to deficits in motivation and goal-directed motor behavior...
October 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/26416545/dimensional-depression-severity-in-women-with-major-depression-and-post-traumatic-stress-disorder-correlates-with-fronto-amygdalar-hypoconnectivty
#7
T D Satterthwaite, P A Cook, S E Bruce, C Conway, E Mikkelsen, E Satchell, S N Vandekar, T Durbin, R T Shinohara, Y I Sheline
Depressive symptoms are common in multiple psychiatric disorders and are frequent sequelae of trauma. A dimensional conceptualization of depression suggests that symptoms should be associated with a continuum of deficits in specific neural circuits. However, most prior investigations of abnormalities in functional connectivity have typically focused on a single diagnostic category using hypothesis-driven seed-based analyses. Here, using a sample of 105 adult female participants from three diagnostic groups (healthy controls, n=17; major depression, n=38; and post-traumatic stress disorder, n=50), we examine the dimensional relationship between resting-state functional dysconnectivity and severity of depressive symptoms across diagnostic categories using a data-driven analysis (multivariate distance-based matrix regression)...
July 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/26260493/brain-connectomics-predict-response-to-treatment-in-social-anxiety-disorder
#8
S Whitfield-Gabrieli, S S Ghosh, A Nieto-Castanon, Z Saygin, O Doehrmann, X J Chai, G O Reynolds, S G Hofmann, M H Pollack, J D E Gabrieli
We asked whether brain connectomics can predict response to treatment for a neuropsychiatric disorder better than conventional clinical measures. Pre-treatment resting-state brain functional connectivity and diffusion-weighted structural connectivity were measured in 38 patients with social anxiety disorder (SAD) to predict subsequent treatment response to cognitive behavioral therapy (CBT). We used a priori bilateral anatomical amygdala seed-driven resting connectivity and probabilistic tractography of the right inferior longitudinal fasciculus together with a data-driven multivoxel pattern analysis of whole-brain resting-state connectivity before treatment to predict improvement in social anxiety after CBT...
May 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/26033240/connectome-wide-network-analysis-of-youth-with-psychosis-spectrum-symptoms
#9
T D Satterthwaite, S N Vandekar, D H Wolf, D S Bassett, K Ruparel, Z Shehzad, R C Craddock, R T Shinohara, T M Moore, E D Gennatas, C Jackson, D R Roalf, M P Milham, M E Calkins, H Hakonarson, R C Gur, R E Gur
Adults with psychotic disorders have dysconnectivity in critical brain networks, including the default mode (DM) and the cingulo-opercular (CO) networks. However, it is unknown whether such deficits are present in youth with less severe symptoms. We conducted a multivariate connectome-wide association study examining dysconnectivity with resting state functional magnetic resonance imaging in a population-based cohort of 188 youths aged 8-22 years with psychosis-spectrum (PS) symptoms and 204 typically developing (TD) comparators...
December 2015: Molecular Psychiatry
https://www.readbyqxmd.com/read/25753600/discrimination-of-schizophrenia-auditory-hallucinators-by-machine-learning-of-resting-state-functional-mri
#10
Darya Chyzhyk, Manuel Graña, Döst Öngür, Ann K Shinn
Auditory hallucinations (AH) are a symptom that is most often associated with schizophrenia, but patients with other neuropsychiatric conditions, and even a small percentage of healthy individuals, may also experience AH. Elucidating the neural mechanisms underlying AH in schizophrenia may offer insight into the pathophysiology associated with AH more broadly across multiple neuropsychiatric disease conditions. In this paper, we address the problem of classifying schizophrenia patients with and without a history of AH, and healthy control (HC) subjects...
May 2015: International Journal of Neural Systems
https://www.readbyqxmd.com/read/25155877/glutathione-deficit-impairs-myelin-maturation-relevance-for-white-matter-integrity-in-schizophrenia-patients
#11
A Monin, P S Baumann, A Griffa, L Xin, R Mekle, M Fournier, C Butticaz, M Klaey, J H Cabungcal, P Steullet, C Ferrari, M Cuenod, R Gruetter, J P Thiran, P Hagmann, P Conus, K Q Do
Schizophrenia pathophysiology implies both abnormal redox control and dysconnectivity of the prefrontal cortex, partly related to oligodendrocyte and myelin impairments. As oligodendrocytes are highly vulnerable to altered redox state, we investigated the interplay between glutathione and myelin. In control subjects, multimodal brain imaging revealed a positive association between medial prefrontal glutathione levels and both white matter integrity and resting-state functional connectivity along the cingulum bundle...
July 2015: Molecular Psychiatry
https://www.readbyqxmd.com/read/25092248/a-functional-mri-marker-may-predict-the-outcome-of-electroconvulsive-therapy-in-severe-and-treatment-resistant-depression
#12
J A van Waarde, H S Scholte, L J B van Oudheusden, B Verwey, D Denys, G A van Wingen
Electroconvulsive therapy (ECT) is effective even in treatment-resistant patients with major depression. Currently, there are no markers available that can assist in identifying those patients most likely to benefit from ECT. In the present study, we investigated whether resting-state network connectivity can predict treatment outcome for individual patients. We included forty-five patients with severe and treatment-resistant unipolar depression and collected functional magnetic resonance imaging scans before the course of ECT...
May 2015: Molecular Psychiatry
https://www.readbyqxmd.com/read/23774715/the-autism-brain-imaging-data-exchange-towards-a-large-scale-evaluation-of-the-intrinsic-brain-architecture-in-autism
#13
A Di Martino, C-G Yan, Q Li, E Denio, F X Castellanos, K Alaerts, J S Anderson, M Assaf, S Y Bookheimer, M Dapretto, B Deen, S Delmonte, I Dinstein, B Ertl-Wagner, D A Fair, L Gallagher, D P Kennedy, C L Keown, C Keysers, J E Lainhart, C Lord, B Luna, V Menon, N J Minshew, C S Monk, S Mueller, R-A Müller, M B Nebel, J T Nigg, K O'Hearn, K A Pelphrey, S J Peltier, J D Rudie, S Sunaert, M Thioux, J M Tyszka, L Q Uddin, J S Verhoeven, N Wenderoth, J L Wiggins, S H Mostofsky, M P Milham
Autism spectrum disorders (ASDs) represent a formidable challenge for psychiatry and neuroscience because of their high prevalence, lifelong nature, complexity and substantial heterogeneity. Facing these obstacles requires large-scale multidisciplinary efforts. Although the field of genetics has pioneered data sharing for these reasons, neuroimaging had not kept pace. In response, we introduce the Autism Brain Imaging Data Exchange (ABIDE)-a grassroots consortium aggregating and openly sharing 1112 existing resting-state functional magnetic resonance imaging (R-fMRI) data sets with corresponding structural MRI and phenotypic information from 539 individuals with ASDs and 573 age-matched typical controls (TCs; 7-64 years) (http://fcon_1000...
June 2014: Molecular Psychiatry
https://www.readbyqxmd.com/read/23739835/abnormal-rich-club-organization-and-functional-brain-dynamics-in-schizophrenia
#14
Martijn P van den Heuvel, Olaf Sporns, Guusje Collin, Thomas Scheewe, René C W Mandl, Wiepke Cahn, Joaquín Goñi, Hilleke E Hulshoff Pol, René S Kahn
IMPORTANCE: The human brain forms a large-scale structural network of regions and interregional pathways. Recent studies have reported the existence of a selective set of highly central and interconnected hub regions that may play a crucial role in the brain's integrative processes, together forming a central backbone for global brain communication. Abnormal brain connectivity may have a key role in the pathophysiology of schizophrenia. OBJECTIVE: To examine the structure of the rich club in schizophrenia and its role in global functional brain dynamics...
August 2013: JAMA Psychiatry
https://www.readbyqxmd.com/read/22432454/empirical-evaluations-of-slice-timing-smoothing-and-normalization-effects-in-seed-based-resting-state-functional-magnetic-resonance-imaging-analyses
#15
Changwei W Wu, Chia-Lin Chen, Po-Yu Liu, Yi-Ping Chao, Bharat B Biswal, Ching-Po Lin
Recently, functional connectivity analyses using spontaneous functional magnetic resonance imaging (fMRI) fluctuations have been applied in the context of neurological and psychiatry diseases. In the analyses procedure, preprocessing steps are commonly utilized in exploring functional connectivity, the same strategy as what was conducted in the fMRI process. However, the effectiveness of these preprocessing steps on resting-state fMRI (rs-fMRI) was rarely investigated, and the significance of preprocessing steps on rs-fMRI needs to be studied...
2011: Brain Connectivity
https://www.readbyqxmd.com/read/21602829/discovering-imaging-endophenotypes-for-major-depression
#16
REVIEW
G Hasler, G Northoff
Psychiatry research lacks an in-depth understanding of mood disorders phenotypes, leading to limited success of genetics studies of major depressive disorder (MDD). The dramatic progress in safe and affordable magnetic resonance-based imaging methods has the potential to identify subtle abnormalities of neural structures, connectivity and function in mood disordered subjects. This review paper presents strategies to improve the phenotypic definition of MDD by proposing imaging endophenotypes derived from magnetic resonance spectroscopy measures, such as cortical gamma-amino butyric acid (GABA) and glutamate/glutamine concentrations, and from measures of resting-state activity and functional connectivity...
June 2011: Molecular Psychiatry
https://www.readbyqxmd.com/read/20433323/brain-networks-foundations-and-futures-in-bipolar-disorder
#17
REVIEW
Lena Palaniyappan, David Andrew Cousins
BACKGROUND: Bipolar affective disorder is a common psychiatric illness with an often episodic nature, the neurobiological basis of which remains elusive. Symptom clusters in bipolar disorder can be conceptualized in terms of disordered brain networks, and doing so may aid our understanding of the varied presentations, differing illness courses and treatment responses. AIMS: To review the rationale behind proposed disordered brain network function in bipolar disorder and the evidence of network dysfunction from imaging studies together with an overview of more novel techniques pertinent to this field...
April 2010: Journal of Mental Health
https://www.readbyqxmd.com/read/19520177/matlab-toolbox-for-functional-connectivity
#18
Dongli Zhou, Wesley K Thompson, Greg Siegle
The term "functional connectivity" is used to denote correlations in activation among spatially-distinct brain regions, either in a resting state or when processing external stimuli. Functional connectivity has been extensively evaluated with several functional neuroimaging methods, particularly PET and fMRI. Yet these relationships have been quantified using very different measures and the extent to which they index the same constructs is unclear. We have implemented a variety of these functional connectivity measures in a new freely available MATLAB toolbox...
October 1, 2009: NeuroImage
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