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Cord blood transplantation

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https://www.readbyqxmd.com/read/29678809/delayed-immune-reconstitution-after-allogeneic-transplantation-increases-the-risks-of-mortality-and-chronic-gvhd
#1
Nelli Bejanyan, Claudio G Brunstein, Qing Cao, Aleksandr Lazaryan, Xianghua Luo, Julie Curtsinger, Rohtesh S Mehta, Erica Warlick, Sarah A Cooley, Bruce R Blazar, Jeffrey S Miller, Daniel Weisdorf, John E Wagner, Michael R Verneris
Slow immune reconstitution is a major obstacle to the successful use of allogeneic hematopoietic cell transplantation (allo-HCT). As matched sibling donor (MSD) allo-HCT is regarded as the gold standard, we evaluated the pace of immune reconstitution in 157 adult recipients of reduced-intensity conditioning followed by MSD peripheral blood HCT (n = 68) and compared these to recipients of umbilical cord blood (UCB; n = 89). At day 28, UCB recipients had fewer natural killer (NK) cells than MSD recipients, but thereafter, NK cell numbers (and their subsets) were higher in UCB recipients...
April 24, 2018: Blood Advances
https://www.readbyqxmd.com/read/29675374/comparison-of-three-fluorescence-labeling-and-tracking-methods-of-endothelial-progenitor-cells-in-laser-injured-retina
#2
Hui Shi, Xin-Rui Wang, Ming-Chao Bi, Wei Yang, Dan Wang, Hai-Le Liu, Ling-Ling Liang, Xiao-Hong Li, Qian Hao, Zhi-Hua Cui, E Song
AIM: To compare three kinds of fluorescent probes for in vitro labeling and in vivo tracking of endothelial progenitor cells (EPCs) in a mouse model of laser-induced retinal injury. METHODS: EPCs were isolated from human umbilical cord blood mononuclear cells and labeled with three different fluorescent probes: 5-(and-6)-carboxyfluorescein diacetate succinimidyl ester (CFSE), 1,1'-dilinoleyl-3,3,3',3'-tetramethylindo-carbocyanine perchlorate linked acetylated low-density lipoprotein (DiI-AcLDL), and green fluorescent protein (GFP)...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29668073/sequential-systematic-anti-mold-prophylaxis-with-micafungin-and-voriconazole-results-in-very-low-incidence-of-invasive-mold-infections-in-patients-undergoing-allogeneic-hematopoietic-stem-cell-transplantation
#3
Claudia Rosillo, Ana Maria Avila, Yao-Ting Huang, Sean Devlin, Christina Cho, Juan Montoro, Molly A Maloy, Genovefa A Papanicolaou, Pere Barba, Miguel-Angel Perales
BACKGROUND AND OBJECTIVES: Recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT) are at high risk for invasive mold infections (IMI). The goal of the study is to describe the incidence and outcome of IMI in patients after allo-HSCT in a large cohort of patients receiving anti-mold prophylaxis. METHODS: We conducted a retrospective review of 988 consecutive adults who underwent allo-HSCT in our center from 2008 through 2014. Standard prophylaxis consisted of micafungin 150mg IV daily from admission to day +7 +/- 3 followed by voriconazole until day +75 to +100...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29668040/graft-loss-attributed-to-possible-transfusion-transmitted-ehrlichiosis-following-cord-blood-stem-cell-transplant
#4
A Mah, G M Viola, E Ariza Heredia, K Rezvani, P Kebriaei, M M Bhatti, X Han, E J Shpall, V Mulanovich
We present a case of possible transfusion-transmitted Ehrlichia chaffeensis infection in a heavily transfused cord blood transplant recipient, resulting in severe infection and graft loss. Transfusion-transmitted, vector-borne infections in immunocompromised individuals can have severe consequences, and should be considered in hospitalized patients receiving blood products with unexplained fever or sepsis. This article is protected by copyright. All rights reserved.
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29666049/m1-and-m2-macrophages-differentially-regulate-hematopoietic-stem-cell-self-renewal-and-ex-vivo-expansion
#5
Yi Luo, Lijian Shao, Jianhui Chang, Wei Feng, Y Lucy Liu, Michele H Cottler-Fox, Peter D Emanuel, Martin Hauer-Jensen, Irwin D Bernstein, Lingbo Liu, Xing Chen, Jianfeng Zhou, Peter J Murray, Daohong Zhou
Uncovering the cellular and molecular mechanisms by which hematopoietic stem cell (HSC) self-renewal is regulated can lead to the development of new strategies for promoting ex vivo HSC expansion. Here, we report the discovery that alternative (M2)-polarized macrophages (M2-MΦs) promote, but classical (M1)-polarized macrophages (M1-MΦs) inhibit, the self-renewal and expansion of HSCs from mouse bone marrow (BM) in vitro. The opposite effects of M1-MΦs and M2-MΦs on mouse BM HSCs were attributed to their differential expression of nitric oxide synthase 2 (NOS2) and arginase 1 (Arg1), because genetic knockout of Nos2 and Arg1 or inhibition of these enzymes with a specific inhibitor abrogated the differential effects of M1-MΦs and M2-MΦs...
April 24, 2018: Blood Advances
https://www.readbyqxmd.com/read/29660452/simulation-of-non-inherited-maternal-antigens-acceptable-hla-mismatches-to-increase-the-chance-of-matched-cord-blood-units-hong-kong-s-experience
#6
Janette Kwok, Mengbiao Guo, Wanling Yang, Patrick Ip, C K Lee, Liwei Lu, Godfrey C F Chan, Derek Middleton, Henk G M van der Zanden
In Cord blood transplantation (CBT), the non-inherited maternal antigen (NIMA) virtual six HLA matched CB is found to have similar outcomes to six HLA inherited matched CB. Such virtual HLA matched CB units can be generated by substituting the inherited alleles with one to three NIMAs. In Hong Kong Cord Blood Bank, CB units have no NIMA defined. 100 CB samples were collected with NIMA defined. Retrospective searches of Hong Kong patients (n = 520) were matched against the inherited and virtual HLA phenotypes of NIMA CB file...
April 13, 2018: Human Immunology
https://www.readbyqxmd.com/read/29659011/immune-system-augmentation-via-humanization-using-stem-progenitor-cells-and-bioengineering-in-a-breast-cancer-model-study
#7
Abbas Shafiee, Jacqui A McGovern, Christoph A Lahr, Christoph Meinert, Davide Moi, Ferdinand Wagner, Marietta Landgraf, Elena De-Juan-Pardo, Roberta Mazzieri, Dietmar W Hutmacher
Despite significant advances, most current in vivo models fail to fully recapitulate the biological processes that occur in humans. Here we aimed to develop an advanced humanized model with features of an organ bone by providing different bone tissue cellular compartments including pre-osteoblasts, mesenchymal stem/stromal (MSCs), endothelial and hematopoietic cells in an engineered microenvironment. The bone compartment was generated by culturing the human MSCs, umbilical vein endothelial cells with gelatin methacryloyl hydrogels in the centre of a melt-electrospun polycaprolactone tubular scaffolds which were seeded with human pre-osteoblasts...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29655601/placental-disposition-of-the-immunosuppressive-drug-tacrolimus-in-renal-transplant-recipients-and-in-ex-vivo-perfused-placental-tissue
#8
J J M Freriksen, D Feyaerts, P H H van den Broek, O W H van der Heijden, J van Drongelen, H W van Hamersvelt, F G M Russel, R G van der Molen, R Greupink
Currently, tacrolimus is the most potent immunosuppressive agent for renal transplant recipients and is commonly prescribed during pregnancy. As data on placental exposure and transfer are limited, we studied tacrolimus placental handling in samples obtained from renal transplant recipients. We found transfer to venous umbilical cord blood, but particularly noted a strong placental accumulation. In patient samples, tissue concentrations in a range of 55-82 ng/g were found. More detailed ex vivo dual-side perfusions of term placentas from healthy women revealed a tissue-to-maternal perfusate concentration ratio of 113 ± 49 (mean ± SEM), underlining the placental accumulation found in vivo...
April 12, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29650777/-mll-leukemia-induction-by-t-9-11-chromosomal-translocation-in-human-hematopoietic-stem-cells-using-genome-editing
#9
Corina Schneidawind, Johan Jeong, Dominik Schneidawind, In-Suk Kim, Jesús Duque-Afonso, Stephen Hon Kit Wong, Masayuki Iwasaki, Erin H Breese, James L Zehnder, Matthew Porteus, Michael L Cleary
Genome editing provides a potential approach to model de novo leukemogenesis in primary human hematopoietic stem and progenitor cells (HSPCs) through induction of chromosomal translocations by targeted DNA double-strand breaks. However, very low efficiency of translocations and lack of markers for translocated cells serve as barriers to their characterization and model development. Here, we used transcription activator-like effector nucleases to generate t(9;11) chromosomal translocations encoding MLL-AF9 and reciprocal AF9-MLL fusion products in CD34+ human cord blood cells...
April 24, 2018: Blood Advances
https://www.readbyqxmd.com/read/29649618/preimplantation-high-resolution-hla-sequencing-using-next-generation-sequencing
#10
Maryam Rafati, Mohammad Mahdi Akhondi, Mohammad Reza Sadeghi, Seyedeh Zahra Tara, Saeed Reza Ghaffari
Hematopoietic Stem Cell Transplantation (HSCT) is the only therapeutic option in a number of heritable hematologic disorders as well as hematologic cancers. Many parents and families fail to find an HLA-identical donor for their affected family member. In such cases, conceiving for a savior baby remains the only option especially in countries without access to national registries. By means of Next Generation Sequencing (NGS) techniques, in a single experiment on single cell products of IVF, a healthy HLA-identical embryo can be implanted in the uterus of a concerned mother...
April 9, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29648492/azacitidine-effectively-reduces-tp53-mutant-leukemic-cell-burden-in-secondary-acute-myeloid-leukemia-after-cord-blood-transplantation
#11
Tomomi Takei, Kazuaki Yokoyama, Eigo Shimizu, Takaaki Konuma, Satoshi Takahashi, Rui Yamaguchi, Seiya Imoto, Satoru Miyano, Arinobu Tojo
No abstract text is available yet for this article.
April 12, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29618687/-successful-cord-blood-transplantation-in-a-patient-with-adult-onset-common-variable-immunodeficiency
#12
Yuhei Harutani, Shinobu Tamura, Hiroshi Kobata, Takehiro Oiwa, Yusuke Yamashita, Toshiki Mushino, Hiroki Hosoi, Shogo Murata, Akinori Nishikawa, Kohsuke Imai, Tomohiro Morio, Takashi Sonoki
Common variable immunodeficiency (CVID) is the most frequently diagnosed congenital immunodeficiency and is characterized by dysfunctional antibody production. It often occurs at the age of ≥10 years. Here we reported a case of a 46-year-old man confirmed with adult-onset CVID. He was effectively treated with cord blood transplant (CBT). The patient was observed with repeated upper respiratory infection a few years back and was referred to our department owing to a marked decrease in neutrophil counts and progression of anemia...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29615915/application-of-mesenchymal-stem-cells-for-therapeutic-agent-delivery-in-anti-tumor-treatment
#13
REVIEW
Daria S Chulpanova, Kristina V Kitaeva, Leysan G Tazetdinova, Victoria James, Albert A Rizvanov, Valeriya V Solovyeva
Mesenchymal stem cells (MSCs) are non-hematopoietic progenitor cells, which can be isolated from different types of tissues including bone marrow, adipose tissue, tooth pulp, and placenta/umbilical cord blood. There isolation from adult tissues circumvents the ethical concerns of working with embryonic or fetal stem cells, whilst still providing cells capable of differentiating into various cell lineages, such as adipocytes, osteocytes and chondrocytes. An important feature of MSCs is the low immunogenicity due to the lack of co-stimulatory molecules expression, meaning there is no need for immunosuppression during allogenic transplantation...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29614627/sickle-cell-disease-classification-of-clinical-complications-and-approaches-to-preventive-and-therapeutic-management
#14
Samir K Ballas
Sickle cell disease (SCD) is an inherited disorder of hemoglobin structure that has no established cure in adult patients. Cure has been achieved in selected children with sickle cell anemia (SCA) using allogeneic bone marrow transplantation or cord blood transplantation. SCD is essentially a triumvirate of (1) pain syndromes, (2) anemia and its sequelae and (3) organ failure, including infection. Pain, however, is the hallmark of SCD and dominates its clinical picture throughout the life of the patients. The prevalence of these complications varies with age from infancy through adult life...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29608607/pharmacokinetics-adapted-busulfan-based-myeloablative-conditioning-before-unrelated-umbilical-cord-blood-transplantation-for-myeloid-malignancies-in-children
#15
Joy Benadiba, Marc Ansari, Maja Krajinovic, Marie-France Vachon, Michel Duval, Pierre Teira, Sonia Cellot, Henrique Bittencourt
Unrelated umbilical cord blood transplantation (UCBT) is an alternative to provide transplants in children with acute leukemia or myelodysplastic syndrome who lack a related donor. Intravenous Busulfan (Bu) combined with therapeutic drug monitoring-guided dosing has been increasingly used, with more predictable bioavailability and better outcomes comparing to oral Bu. There is still an important variation in Bu pharmacokinetic between patients that is associated with an increased risk of toxicity and graft failure...
2018: PloS One
https://www.readbyqxmd.com/read/29608487/enhancing-human-cord-blood-hematopoietic-stem-cell-engraftment-by-targeting-nuclear-hormone-receptors
#16
Bin Guo, Xinxin Huang, Hal E Broxmeyer
PURPOSE OF REVIEW: Allogeneic hematopoietic cell transplantation (HCT) is a life-saving therapy for hematological and nonhematological diseases. Cord blood is a source of transplantable hematopoietic stem cells (HSCs), but limited numbers of HSCs in single cord blood units, which may cause delayed neutrophil, platelet, and immune cell reconstitution, is a major problem for efficient transplantation. Ex-vivo expansion and enhanced homing of cord blood HSC may overcome this disadvantage and improve its long-term engraftment...
March 31, 2018: Current Opinion in Hematology
https://www.readbyqxmd.com/read/29607499/assessing-opportunities-and-challenges-for-establishing-a-national-program-to-distribute-cord-blood-for-research
#17
Rosario Isasi, Cherie Mastronardi, Mia Golder, David Allan, Mark Walker, Mike Halpenny, Lin Yang, Heidi Elmoazzen, Sophie Chargé
BACKGROUND: Research is needed to enhance cord blood (CB) transplantation outcomes and to develop new clinical applications. Based on quality criteria for transplantation, CB collected by public CB banks (CBBs) is often unsuitable for banking, but may still be valuable for research. Canadian researchers have described a need for a centralized program providing ethically sourced CB for research projects. To meet this need, Canadian Blood Services (CBS), in partnership with The Ottawa Hospital, launched the Cord Blood for Research Program (CBRP) in 2014...
April 1, 2018: Transfusion
https://www.readbyqxmd.com/read/29578087/current-approaches-in-biomaterial-based-hematopoietic-stem-cell-niches
#18
REVIEW
Alvin Bacero Bello, Hansoo Park, Soohong Lee
Hematopoietic stem cells (HSCs) are multipotent progenitor cells that can differentiate and replenish blood and immune cells. While there is a growing demand for autologous and allogeneic HSC transplantation owing to the increasing incidence of hereditary and hematologic diseases, the low population of HSCs in cord-blood and bone marrow (the main source of HSCs) hinders their medical applicability. Several cytokine and growth factor-based methods have been developed to expand the HSCs in vitro; however, the expansion rate is low, or the expanded cells fail to survive upon engraftment...
March 22, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29577604/neurotrophin-3-released-from-implant-of-tissue-engineered-fibroin-scaffolds-inhibits-inflammation-enhances-nerve-fiber-regeneration-and-improves-motor-function-in-canine-spinal-cord-injury
#19
Ge Li, Ming-Tian Che, Xiang Zeng, Xue-Cheng Qiu, Bo Feng, Bi-Qin Lai, Hui-Yong Shen, Eng-Ang Ling, Yuan-Shan Zeng
Spinal cord injury (SCI) normally results in cell death, scarring, cavitation, inhibitory molecules release, etc., which are regarded as a huge obstacle to reconnect the injured neuronal circuits due to the lack of effective stimulus. In this study, a functional gelatin sponge scaffold was used to inhibit local inflammation, enhance nerve fiber regeneration and improve neural conduction in the canine. This scaffold had good porosity and modified with neurotrophin-3 (NT-3)/fibroin complex, which showed sustained release in vitro...
March 25, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29574172/concentration-of-the-cdcp1-protein-in-human-cord-plasma-may-serve-as-a-predictor-of-hematopoietic-stem-and-progenitor-cell-content
#20
Sofia Frändberg, Julia Asp, Berit Waldner, Jan Holgersson, Lars Palmqvist
Successful hematopoietic stem and progenitor cell (HSPC) transplantation rests upon reliable methods for their enumeration in sources such as cord blood (CB). Methods used today are costly, time consuming and exhaust the limited number of cells needed for transplantation. The aim of this study was to analyze if surplus plasma from CB contains biomarkers that can predict HSPC content in CB. Frozen, surplus plasma from 95 CB units was divided into two groups based on CD34+ cell concentration. Birth weight, gestation age, gender, mode of delivery, collection volume, nucleated cell count and colony forming unit assay results were available...
March 16, 2018: Stem Cell Research
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