keyword
https://read.qxmd.com/read/38527841/-single-non-blood-related-umbilical-cord-blood-transplantation-using-a-reduced-intensity-conditioning-regimen-for-the-treatment-of-severe-aplastic-anemia
#1
JOURNAL ARTICLE
Y Wu, B L Tang, K D Song, G Y Sun, T Z Pan, A J Huang, B B Yan, X Y Zhu
Objective: To evaluated the clinical efficacy of a reduced-intensity preconditioning regimen for single non-blood-related umbilical cord blood transplantation (sUCBT) in the treatment of severe aplastic anemia (SAA) . Methods: The clinical data of 63 patients with SAA who underwent sUCBT from January 2021 to July 2023 at the Department of Hematology of the First Affiliated Hospital of USTC were retrospectively analyzed. Fifty-two patients received total body irradiation/total bone marrow irradiation (TMI) combined with fludarabine or a cyclophosphamide- conditioning regimen (non-rATG group) , while 11 patients received rabbit anti-human thymocyte immunoglobulin (rATG) combined with TMI, fludarabine, or the cyclophosphamide-conditioning regimen (rATG group) ...
January 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/38523199/sustained-remission-after-cord-blood-transplantation-for-breast-cancer-with-lung-metastases-and-myelodysplastic-syndrome
#2
JOURNAL ARTICLE
Naokazu Nakamura, Nao Yamamoto, Tadakazu Kondo, Mayumi Matsumoto, Ryo Ikunari, Tomomi Sakai, Yasuhiro Tanaka, Hiroko Tsunemine, June Takeda, Junya Kanda, Yasuhito Nannya, Seishi Ogawa, Akifumi Takaori-Kondo, Nobuyoshi Arima
Allogenic hematopoietic stem cell transplantation (allo-HSCT) is not a standard therapy for solid cancer because of its high toxicity and insufficient evidence levels. However, the potential graft-versus-solid-tumor (GVT) effect of this therapy has been discussed. Many case reports have also described treatment effects of allo-HSCT in patients with hematologic malignancies and active solid tumors. A 38-year-old woman treated with fulvestrant and abemaciclib for recurrent breast cancer with multiple lung metastases was diagnosed with myelodysplastic syndrome (MDS) with increased blasts 2...
March 25, 2024: International Journal of Hematology
https://read.qxmd.com/read/38521608/impact-of-fda-s-hct-p-zikv-recommendations-on-cord-blood-unit-eligibility-and-utilization-in-a-large-public-cord-blood-bank
#3
JOURNAL ARTICLE
Dana S Guggenheim, Joanne Kurtzberg, Beth H Shaz
BACKGROUND: Cord blood units (CBUs) that are ineligible for licensure due to incomplete compliance with FDA recommendations may be used for hematopoietic stem cell transplantation under urgent medical need and an Investigational Drug Application. The largest reason for CBU donor ineligibility is Zika virus (ZIKV) risk. The study's objective was to analyze the impact of current FDA recommendations for ZIKA risk on a large public cord blood bank and propose updated recommendations. METHODS: We performed a retrospective analysis of Carolinas Cord Blood Bank (CCBB), an FDA licensed public CBB, using data from January 1, 2016 to November 21, 2023 and compared FDA recommendations for transfusion transmitted infections (TTI) for blood products and relevant communicable disease agents or diseases for human cell, tissue, or cellular or tissue-based products (HCT/Ps)...
March 23, 2024: Stem Cells Translational Medicine
https://read.qxmd.com/read/38511389/impact-of-donor-nkg2d-and-mica-gene-polymorphism-on-clinical-outcomes-of-adult-and-paediatric-allogeneic-cord-blood-transplantation-for-malignant-diseases
#4
JOURNAL ARTICLE
Steven T Cox, Warren Patterson, Richard Duggleby, Owen J R Jones, J Alejandro Madrigal, Sergi Querol, Francesc Rudilla Salvador, Maria Jose Herrero Mata, Fernanda Volt, Éliane Gluckman, Richard Szydlo, Robert D Danby, Diana Hernandez
OBJECTIVES: NKG2D is an activating receptor expressed by natural killer (NK) and CD8+ T cells and activation intensity varies by NKG2D expression level or nature of its ligand. An NKG2D gene polymorphism determines high (HNK1) or low (LNK1) expression. MICA is the most polymorphic NKG2D ligand and stronger effector cell activation associates with methionine rather than valine at residue 129. We investigated correlation between cord blood (CB) NKG2D and MICA genotypes and haematopoietic stem cell (HSC) transplant outcome...
March 21, 2024: European Journal of Haematology
https://read.qxmd.com/read/38496190/atypical-peripheral-retinal-necrosis-without-ocular-inflammation-and-retinal-whitening-in-a-patient-with-acute-myelogenous-leukemia-a-case-report
#5
Yoshihiro Nakagawa, Xue Tan, Hikari Yoshida, Takahiro Suzuki, Yasuyuki Suzuki
Retinal necrosis is a severe condition that threatens visual function. It is caused by viruses that are known to cause acute retinal necrosis (ARN) and progressive outer retinal necrosis (PORN), which are called necrotizing herpetic retinopathies (NHR). ARN causes severe intraocular inflammation, including anterior chamber intravitreal cells, keratic precipitate, vitreous opacity, and retinal vasculitis, whereas intraocular inflammation in PORN is considered mild or virtually absent. In addition, PORN is a disease that manifests in immunosuppressive patients, such as those with acquired immunodeficiency syndrome...
February 2024: Curēus
https://read.qxmd.com/read/38486352/klotho-in-pregnancy-and-intrauterine-development-potential-clinical-implications-a-review-from-the-european-renal-association-ckd-mbd-working-group
#6
JOURNAL ARTICLE
Mehmet Kanbay, Ali Mutlu, Cicek N Bakir, Ibrahim B Peltek, Ata A Canbaz, Juan Miguel Díaz Tocados, Mathias Haarhaus
Intrauterine development is crucial for life-long health; therefore, elucidation of its key regulators is of interest for their potential prognostic and therapeutic implications. Originally described as a membrane-bound anti-aging protein, Klotho has evolved as a regulator of numerous functions in different organ systems. Circulating Klotho is generated by alternative splicing or active shedding from cell membranes. Recently, Klotho was identified as a regulator of placental function, and while Klotho does not cross the placental barrier, increased levels of circulating α-Klotho have been identified in umbilical cord blood compared to maternal blood, indicating that Klotho may also play a role in intrauterine development...
March 14, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38485627/-update-for-cord-blood-unit-selection-in-hematopoietic-stem-cell-transplantation-workshop-sfgm-tc
#7
Valérie Dubois, Lucie Blandin, Marion Duclaut, Alix Duquesne, Lionel Faivre, Romain Ferru-Clement, Jean Roy, Alexandre Walencik, Leonardo Magro, Federico Garnier
Changing practices and the limited use of cord blood units as a source of cells for allogeneic hematopoietic stem cell transplants (HSC) led us to reconsider the recommendations established in 2011 and 2012, and to propose an update incorporating recent bibliographic data. If HLA compatibility was until now established at low resolution for HLA-A and B loci, and at high resolution for HLA-DRB1, the recent papers are converging towards an increase in the level of resolution, making way for a compatibility now defined in high resolution for all the considered loci, and the inclusion of the HLA-C locus, in order to establish a level of HLA compatibility on 8 alleles (HLA-A, B, C and DRB1)...
March 13, 2024: Bulletin du Cancer
https://read.qxmd.com/read/38481366/the-impact-of-omidubicel-on-immune-reconstitution-and-infections-in-cord-blood-transplant-patients
#8
JOURNAL ARTICLE
Hong De Sa, Richard T Maziarz, Arpita P Gandhi
INTRODUCTION: The success of an allogeneic hematopoietic stem cell transplantation (alloHCT) is measured by cure from the underlying malignancy, immune reconstitution (IR), and freedom from graft-versus-host disease, without the continued need for immunosuppressive therapy. AREAS COVERED: Effective IR is critical to the success of alloHCT wherein poor IR can potentially increase the risk of infection and disease relapse. Different stem cell sources give rise to varying patterns of IR...
March 14, 2024: Expert Opinion on Biological Therapy
https://read.qxmd.com/read/38475797/hematologic-health-services-and-practical-characteristics-report-of-a-nationwide-survey-among-chinese-hematologists
#9
JOURNAL ARTICLE
Jia Chen, Jiali Gu, Yuhua Ru, Jianxiang Wang, Yu Hu, Kaiyan Liu, Qifa Liu, Xiaohui Zhang, Zhijian Xiao, Weili Zhao, Yang Xu, Xiaojun Huang, Depei Wu
BACKGROUND: In the past 40 years, China has experienced tremendous economic development, but the current situation of hematologists has rarely been reported. A landscape survey of human resources is essential for healthcare development and policy formulation in the future. METHODS: The Chinese Society of Hematology initiated a survey of Chinese hematologists in mainland China for evaluating demographic and practice characteristics. Respondents were anonymous, and there were no limitations regarding their age, sex, etc...
March 12, 2024: BMC Health Services Research
https://read.qxmd.com/read/38467271/boundary-cap-neural-crest-stem-cells-promote-angiogenesis-after-transplantation-to-avulsed-dorsal-roots-in-mice-and-induce-migration-of-endothelial-cells-in-3d-printed-scaffolds
#10
JOURNAL ARTICLE
Carl Trolle, Yilin Han, Shivaprakash Jagalur Mutt, Gustaf Christoffersson, Elena N Kozlova
Dorsal root avulsion injuries lead to loss of sensation and to reorganization of blood vessels (BVs) in the injured area. The inability of injured sensory axons to re-enter the spinal cord results in permanent loss of sensation, and often also leads to the development of neuropathic pain. Approaches that restore connection between peripheral sensory axons and their CNS targets are thus urgently need. Previous research has shown that sensory axons from peripherally grafted human sensory neurons are able to enter the spinal cord by growing along BVs which penetrate the CNS from the spinal cord surface...
March 9, 2024: Neuroscience Letters
https://read.qxmd.com/read/38466262/high-dose-individualized-antithymocyte-globulin-with-therapeutic-drug-monitoring-in-high-risk-cord-blood-transplant
#11
JOURNAL ARTICLE
Rick Admiraal, A Birgitta Versluijs, Alwin D R Huitema, Lysette Ebskamp, Amelia Lacna, C T Klaartje de Kanter, Marc B Bierings, Jaap Jan Boelens, Caroline A Lindemans, Stefan Nierkens
BACKGROUND: Graft-versus-host disease (GvHD) and rejection are main limitations of cord blood transplantation (CBT), more so in patients with severe inflammation or previous rejections. While rigorous T-cell depletion with antithymocyte globulin (ATG) is needed to prevent GvHD and rejection, overexposure to ATG leads to slow T-cell recovery after transplantation, especially in CBT. OBJECTIVE: To evaluate high-dose, upfront ATG with individualized dosing and therapeutic drug monitoring (TDM) in pediatric CBT for patients at high risk for GvHD and rejection...
February 23, 2024: Cytotherapy
https://read.qxmd.com/read/38458476/gut-immunomodulation-with-vedolizumab-prior-to-allogeneic-hematopoietic-stem-cell-transplantation-in-pediatric-patients-with-inflammatory-bowel-disease
#12
JOURNAL ARTICLE
Yogi Chopra, Karol Acevedo, Aleixo Muise, Karen Frost, Tal Schechter, Joerg Krueger, Muhammad Ali, Kuang-Yueh Chiang, V Y Kim, Eyal Grunebaum, Donna Wall
BACKGROUND: Inborn errors of immunity (IEI) are often associated with inflammatory bowel disease (IBD). IEI can be corrected by allogeneic hematopoietic stem cell transplantation (HSCT) however peri-transplantation intestinal inflammation may lead to increased risk of gut graft-versus-host disease (GVHD). Vedolizumab inhibits the homing of lymphocytes to the intestine and may attenuate gut GVHD, yet its role in preventing GvHD in pediatric patients with IEI-associated IBD has not been studied...
March 6, 2024: Transplantation and cellular therapy
https://read.qxmd.com/read/38452872/umbilical-cord-blood-transplantation-for-fanconi-anemia-with-a-special-focus-on-late-complications-a-study-on-behalf-of-eurocord-and-saawp-ebmt
#13
JOURNAL ARTICLE
Hanadi Rafii, Fernanda Volt, Marc Bierings, Jean-Hugues Dalle, Mouhab Ayas, Rawad Rihani, Maura Faraci, Giuseppina de Simone, Henrik Sengeloev, Jakob Passweg, Marina Cavazzana, Regis Costello, Johan Maertens, Alessandra Biffi, Jan-Erik Johansson, Juan Montoro, Gabrielle Roth Guepin, Miguel Angel Diaz, Anne Sirvent, Chantal Kenzey, Monica M Rivera Franco, Barbara Cappelli, Graziana Maria Scigliuolo, Vanderson Rocha, Annalisa Ruggeri, Antonio Risitano, Regis Peffault De Latour, Eliane Gluckman
BACKGROUND: Hematopoietic cell transplant (HCT) remains the only available curative treatment for Fanconi Anemia (FA), with particularly favorable outcomes reported after matched sibling donor (MSD) transplant. OBJECTIVES: To describe outcomes, with a special focus on late complications, in FA patients who underwent umbilical cord blood transplantation (UCBT). STUDY DESIGN: Retrospective analysis of allogeneic UCBT for FA performed between 1988 and 2021 in European Society for Blood and Marrow Transplantation (EBMT) affiliated centers...
March 5, 2024: Transplantation and cellular therapy
https://read.qxmd.com/read/38448000/-ovarian-hyperstimulation-syndrome-with-controlled-ovarian-stimulation-after-induction-therapy-for-philadelphia-chromosome-positive-acute-lymphoblastic-leukemia
#14
JOURNAL ARTICLE
Kai Osone, Seiichiro Katagiri, Yuya Arai, Akiko Yamada, Tamiko Suguro, Daigo Akahane, Nahoko Furuya, Hiroaki Fujimoto, Masanori Ono, Akihiko Gotoh
A 27-year-old woman with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia received induction therapy with dasatinib and prednisolone. From the time of diagnosis, oocyte storage was planned in accordance with the patient's wishes. After progesterone administration for suppression of menstruation, and blood cell recovery, ovarian stimulation was performed and a sufficient number of eggs was collected. The patient was considered at high risk for ovarian stimulation syndrome (OHSS) and received cabergoline and letrozole...
2024: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://read.qxmd.com/read/38447268/in-vivo-and-in-vitro-effects-of-cord-blood-hematopoietic-stem-and-progenitor-cell-hspc-expansion-using-valproic-acid-and-or-nicotinamide
#15
JOURNAL ARTICLE
Emine Begum Gencer, Hasan Yalim Akin, Selami Kocak Toprak, Eylul Turasan, Mahsa Yousefzadeh, Pinar Yurdakul-Mesutoglu, Murat Cagan, Mehmet Murat Seval, Doruk Cevdi Katlan, Klara Dalva, Mehmet Sinan Beksac, Meral Beksac
BACKGROUND: High self-renewal capacity and most permissive nature of umbilical cord blood (CB) results with successful transplant outcomes but low hematopoietic stem and progenitor cell (HSPC) counts limits wider use. In order to overcome this problem ex vivo expansion with small molecules such as Valproic acid (VPA) or Nicotinamide (NAM) have been shown to be effective. To the best of our knowledge, the combinatory effects of VPA and NAM on HSPC expansion has not been studied earlier...
March 1, 2024: Current Research in Translational Medicine
https://read.qxmd.com/read/38445374/biodistribution-and-safety-of-human-multi-chimeric-cells-hmcc-after-systemic-intraosseous-and-intravenous-administration-in-the-experimental-mouse-model
#16
JOURNAL ARTICLE
Maria Siemionow, Lucile Chambily, Joanna Cwykiel
Cellular therapies provide promising options for inducing tolerance in transplantation of solid organs, bone marrow, and vascularized composite allografts. However, novel tolerance-inducing protocols remain limited despite extensive research. We previously introduced and characterized a Human Multi-Chimeric Cell (HMCC) line, created through ex vivo fusion of human umbilical cord blood (UCB) cells derived from three unrelated donors. In this study, we assessed in vivo biodistribution and safety of HMCC in the NOD...
March 6, 2024: Stem Cells and Development
https://read.qxmd.com/read/38443990/mesenchymal-stem-stromal-cells-from-human-pluripotent-stem-cell-derived-brain-organoid-enhance-the-ex-vivo-expansion-and-maintenance-of-hematopoietic-stem-progenitor-cells
#17
JOURNAL ARTICLE
Ya Zhou, Xinping Cai, Xiuxiu Zhang, Yong Dong, Xu Pan, Mowen Lai, Yimeng Zhang, Yijin Chen, Xiaohong Li, Xia Li, Jiaxin Liu, Yonggang Zhang, Feng Ma
BACKGROUND: Mesenchymal stem/stromal cells (MSCs) are of great therapeutic value due to their role in maintaining the function of hematopoietic stem/progenitor cells (HSPCs). MSCs derived from human pluripotent stem cells represent an ideal alternative because of their unlimited supply. However, the role of MSCs with neural crest origin derived from HPSCs on the maintenance of HSPCs has not been reported. METHODS: Flow cytometric analysis, RNA sequencing and differentiation ability were applied to detect the characteristics of stromal cells from 3D human brain organoids...
March 5, 2024: Stem Cell Research & Therapy
https://read.qxmd.com/read/38438647/hematopoietic-cell-transplantation-and-cellular-therapies-in-europe-2022-car-t-activity-continues-to-grow-transplant-activity-has-slowed-a-report-from-the-ebmt
#18
JOURNAL ARTICLE
Jakob R Passweg, Helen Baldomero, Fabio Ciceri, Rafael de la Cámara, Bertram Glass, Raffaella Greco, Mette D Hazenberg, Krzysztof Kalwak, Donal P McLornan, Bénédicte Neven, Zinaida Perić, Antonio M Risitano, Annalisa Ruggeri, John A Snowden, Anna Sureda
In 2022, 46,143 HCT (19,011 (41.2%) allogeneic and 27,132 (58.8%) autologous) in 41,854 patients were reported by 689 European centers. 4329 patients received advanced cellular therapies, 3205 of which were CAR-T. An additional 2854 patients received DLI. Changes compared to the previous year were an increase in CAR-T treatments (+27%) and decrease in allogeneic (-4.0%) and autologous HCT (-1.7%). Main indications for allogeneic HCT were myeloid malignancies (10,433; 58.4%), lymphoid malignancies (4,674; 26...
March 4, 2024: Bone Marrow Transplantation
https://read.qxmd.com/read/38436082/co-transplantation-of-umbilical-cord-mesenchymal-stem-cells-and-peripheral-blood-stem-cells-in-children-and-adolescents-with-refractory-or-relapsed-severe-aplastic-anemia
#19
JOURNAL ARTICLE
Fangfang Yuan, Minghui Li, Xudong Wei, Yuewen Fu
To evaluate the co-transplantation efficacy of umbilical cord mesenchymal stem cells (UC-MSCs) and peripheral blood stem cells (PBSCs) as a novel approach for refractory or relapsed severe aplastic anemia (R/R SAA) in children and adolescents, thirty-two children and adolescents diagnosed with R/R SAA underwent a retrospective chart review. The patients were categorized into two groups based on the source of PBSCs: the matched sibling donor (MSD) group and the unrelated donor (UD) group. No adverse events related to UC-MSC infusion occurred in any of the patients...
March 4, 2024: Pediatric Hematology and Oncology
https://read.qxmd.com/read/38427220/projected-impact-of-omidubicel-onlv-on-racial-ethnic-disparities-in-allogeneic-hematopoietic-cell-transplantation-allo-hct-outcomes-in-hematologic-malignancies
#20
JOURNAL ARTICLE
Nandita Khera, Marie Louise Edwards, Yan Song, Rochelle Sun, Rocio Manghani, Heayoung Shin, Ronit Simantov, James Signorovitch, Smitha Sivaraman, Usama Gergis
INTRODUCTION: In a phase III clinical trial (NCT02730299), omidubicel-onlv, a nicotinamide-modified allogeneic hematopoietic progenitor cell therapy, showed rapid hematopoietic and immune recovery compared with standard umbilical cord blood (UCB) transplant across all racial/ethnic groups. METHODS: A decision-tree model was used to project the effect of omidubicel-onlv availability on addressing health disparities in allogeneic hematopoietic cell transplantation (allo-HCT) access and outcomes for patients with hematologic malignancies...
March 1, 2024: Advances in Therapy
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