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Cell Cycle Arrest Biomarkers

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https://www.readbyqxmd.com/read/29220395/microrna-93-promotes-proliferation-and-metastasis-of-gastric-cancer-via-targeting-timp2
#1
Hao Guan, Weiming Li, Yuanyuan Li, Jichang Wang, Yan Li, Yanan Tang, Shaoying Lu
MicroRNAs (miRNAs) are important regulators of pathobiological processes in various cancer. In the present study, we demonstrated that miR-93 expression was significantly up-regulated in gastric cancer tissues compared with that in matched normal mucosal tissues. High expression of miR-93 was significantly associated with lymph node metastasis and tumor-node-metastasis (TNM) stage. Functionally, ectopic expression of miR-93 promoted cell proliferation, migration, invasion, EMT phenotypes, and repressed apoptosis and G1 cell cycle arrest in vitro, and promoted tumor formation in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/29212203/knockdown-of-gtpbp4-inhibits-cell-growth-and-survival-in-human-hepatocellular-carcinoma-and-its-prognostic-significance
#2
Wen-Bin Liu, Wei-Dong Jia, Jin-Liang Ma, Ge-Liang Xu, Hang-Cheng Zhou, Yan Peng, Wei Wang
GTP-binding protein 4 (GTPBP4), as a novel member of GTPases involved in the synthesis of 60S subunit and maturation, is closely related to cell proliferation and growth. Till now, a small number of existing studies have found a contradictory dual role of GTPBP4 in cancer. Whether the expression level of GTPBP4 in hepatocellular carcinoma (HCC) is associated with the patients' prognosis or its function and underlying molecular mechanisms still remains unclear. In the present study, the above issues were explored for the first time...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29209988/lncrna-egot-promotes-tumorigenesis-via-hedgehog-pathway-in-gastric-cancer
#3
Wei Peng, Jianzhong Wu, Hong Fan, Jianwei Lu, Jifeng Feng
Gastric cancer (GC) is one of the mostly terminal malignancies with poor prognosis. Long noncoding RNA EGOT (EGOT) acts as a crucial regulator in the breast cancer. However, the function of EGOT in GC remains unknown. This work was to explore the clinical value and biological significance of EGOT in GC. EGOT levels in GC tissue and cell were analyzed by qRT-PCR. After knockdown of EGOT, GC cell growth and cycle progression were detected. The expression of EGOT was observably elevated in GC. Upregulation of EGOT was related with lymphatic metastasis and TNM stage...
December 5, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29209896/braf-oncogene-induced-senescence-and-the-role-of-thyroid-stimulating-hormone-signaling-in-the-progression-of-papillary-thyroid-carcinoma
#4
REVIEW
F I Moulana, A A H Priyani, M V C de Silva, R S Dassanayake
Oncogene-induced senescence (OIS) explains the phenomenon of cellular senescence triggered by the action of oncogenes. It is a mechanism adopted by a cell to inhibit progression of benign tumors into malignancy, occurs in premalignant lesions, and is almost never present in malignant lesions. BRAF mutations occur in about 40-45% of all papillary thyroid carcinomas (PTCs) and of which 99.7% is the BRAFV600E mutation. A unique phenotype of the BRAFV600E mutation is the upregulation of the thyroid-stimulating hormone receptor (TSHR) on thyrocyte membranes...
December 5, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/29209041/the-e3-ubiquitin-ligase-wwp1-sustains-the-growth-of-acute-myeloid-leukaemiaag-sanarico-et-al
#5
A G Sanarico, C Ronchini, A Croce, E M Memmi, U A Cammarata, A De Antoni, S Lavorgna, M Divona, L Giacò, G E M Melloni, A Brendolan, G Simonetti, G Martinelli, P Mancuso, F Bertolini, F L Coco, G Melino, P G Pelicci, F Bernassola
The E3 ubiquitin ligase (E3) WWP1 is an oncogenic factor implicated in the maintenance of different types of epithelial cancers. The role of WWP1 in haematological neoplasms remains unknown. Acute myeloid leukaemia (AML) is characterized by the expansion of malignant myeloid cells blocked at different stages of differentiation. Here, we report that the expression of WWP1 is significantly augmented in a large cohort of primary AML patients and in AML cell lines, compared to hematopoietic cells from healthy donors...
December 6, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29196104/up-regulation-of-long-noncoding-rna-falec-predicts-poor-prognosis-and-promotes-melanoma-cell-proliferation-through-epigenetically-silencing-p21
#6
Nana Ni, Hao Song, Xiaopo Wang, Xiulian Xu, Yiqun Jiang, Jianfang Sun
Accumulating evidences have suggested that focally amplified lncRNA on chromosome 1 (FALEC) serves as an oncogenic long non-coding RNA (lncRNA) and has been identified to be dysregulated in various tumors. However, the expression, clinical values, and biological function of FALEC in melanoma are still unknown. In this study we detected the expression level of FALEC in tumor tissues and cell lines and measured the prognostic value of FALEC for melanoma patients and the biological effects of FALEC on melanoma cell proliferation, cell cycle, and apoptosis...
November 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29189343/kinetics-of-urinary-cell-cycle-arrest-markers-for-acute-kidney-injury-following-exposure-to-potential-renal-insults
#7
Marlies Ostermann, Peter A McCullough, Lui G Forni, Sean M Bagshaw, Michael Joannidis, Jing Shi, Kianoush Kashani, Patrick M Honore, Lakhmir S Chawla, John A Kellum
OBJECTIVES: Urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 predict the development of acute kidney injury following renal insults of varied aetiology. To aid clinical interpretation, we describe the kinetics of biomarker elevations around an exposure. DESIGN: In an ancillary analysis of the multicenter SAPPHIRE study, we examined the kinetics of the urinary [tissue inhibitor of metalloproteinase-2]•[insulin-like growth factor binding protein 7] in association with exposure to common renal insults (major surgery, IV radiocontrast, vancomycin, nonsteroidal anti-inflammatory drugs, and piperacillin/tazobactam)...
November 20, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29187894/material-induced-senescence-mis-fluidity-induces-senescent-type-cell-death-of-lung-cancer-cells-via-insulin-like-growth-factor-binding-protein-5
#8
Sharmy Saimon Mano, Koichiro Uto, Mitsuhiro Ebara
Objective: We propose here material-induced senescence (MIS) as a new therapeutic concept that limits cancer progression by stable cell cycle arrest. This study examined for the first time the effect of material fluidity on cellular senescence in lung carcinoma using poly(ε-caprolactone-co-D, L-lactide) (P(CL-co-DLLA)) with tunable elasticity and fluidity. Methods: The fluidity was varied by chemically crosslinking the polymer networks: the crosslinked P(CL-co-DLLA) shows solid-like properties with a stiffness of 260 kPa, while the non-crosslinked polymer exists in a quasi-liquid state with loss and storage moduli of 33 kPa and 11 kPa, respectively...
2017: Theranostics
https://www.readbyqxmd.com/read/29158787/high-expression-of-fam83b-predicts-poor-prognosis-in-patients-with-pancreatic-ductal-adenocarcinoma-and-correlates-with-cell-cycle-and-cell-proliferation
#9
Chao-Qin Shen, Ting-Ting Yan, Wei Liu, Xiao-Qiang Zhu, Xiang-Long Tian, Xue-Liang Fu, Rong Hua, Jun-Feng Zhang, Yan-Miao Huo, De-Jun Liu, Jian-Yu Yang, Yong-Wei Sun, Jing-Yuan Fang, Hao-Yan Chen, Jie Hong
FAM83B (family with sequence similarity 83, member B) seems to emerge as a new class of players involved in the development of a variety of malignant tumors. Yet the molecular mechanisms are not well understood. The present study is intended to investigate the expression and function of FAM83B in pancreatic ductal adenocarcinoma (PDAC). In this study, we found that the expression of FAM83B was significantly increased both in PDAC cell lines and PDAC tumor tissues. FAM83B expression was positively related with advanced clinical stage and poor vital status...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29149959/urinary-tissue-inhibitor-of-metalloproteinase-and-insulin-like-growth-factor-7-as-early-biomarkers-of-delayed-graft-function-after-kidney-transplantation
#10
J Yang, S Y Lim, M-G Kim, C-W Jung, W-Y Cho, S-K Jo
BACKGROUND: Recently, urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-7 (IGFBP-7), markers for G1 cell cycle arrest, have been identified and validated in predicting the development of acute kidney injury in critically ill patients. It is unknown, however, whether these two biomarkers could predict the development of delayed graft function (DGF) after kidney transplantation (KT). METHODS: This is a single-center, prospective, observational study...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29146295/new-markers-for-early-detection-of-acute-kidney-injury-after-transcatheter-aortic-valve-implantation
#11
Cedrick Zaouter, Frédérique Priem, Lionel Leroux, Guillaume Bonnet, Marie-Lise Bats, Marie Christine Beauvieux, Alain Rémy, Alexandre Ouattara
BACKGROUND: Acute Kidney Injury (AKI) is a frequent complication after a Transcatheter Aortic Valve Implantation (TAVI). Biomarkers such as urinary G1 cell cycle arrest proteins (TIMP-2 and IGFBP7) and sonographic evaluation (Doppler Renal Resistive Index (RRI)) have been advocated to predict AKI at an early stage after a TAVI-procedure. The primary aim was to determine the predictive value of these markers to detect AKI after a TAVI-procedure at an early phase. PATIENTS AND METHODS: In a prospective observational study, 62 consecutive patients were scheduled for a TAVI...
November 13, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29145164/long-noncoding-rna-hnf1a-as1-indicates-a-poor-prognosis-of-colorectal-cancer-and-promotes-carcinogenesis-via-activation-of-the-wnt-%C3%AE-catenin-signaling-pathway
#12
Xin Zhang, Yumin Xiong, Fengying Tang, Ying Bian, Yanhui Chen, Fengli Zhang
Long non-coding RNAs (lncRNAs) have been identified to play critical roles in tumorigenesis. LncRNA HNF1A-AS1 has been suggested to act as an oncogene and serves as a novel prognostic biomarker for various cancer. However, the biological role and clinical significance of lncRNA HNF1A-AS1 in colorectal cancer (CRC) have yet to be fully elusive. Therefore, the present study was designed to determine the expression of lncRNA HNF1A-AS1 in patients with CRC, the role of lncRNA HNF1A-AS1 in CRC cells, as well as the underlying regulatory mechanisms...
October 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29142597/microrna-193a-3p-inhibits-cell-proliferation-in-prostate-cancer-by-targeting-cyclin-d1
#13
Yunfu Liu, Xin Xu, Xianglai Xu, Shiqi Li, Zhen Liang, Zhenghui Hu, Jian Wu, Yi Zhu, Xiaodong Jin, Xiao Wang, Yiwei Lin, Hong Chen, Yeqing Mao, Jindan Luo, Xiangyi Zheng, Liping Xie
MicroRNAs (miRNAs) are small non-coding RNAs that affect various biological processes by altering the expression of a target gene. An miRNA microarray analysis has previously revealed a significant decrease in miR-193a-3p levels in prostate cancer tissues compared with that in their benign prostate hyperplasia counterparts. However, the role of miR-193a-3p has yet to be elucidated. In the present study, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to evaluate the expression levels of miR-193a-3p in two human prostate cancer cell lines...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29139562/lncrna-ghet1-predicts-poor-prognosis-in-hepatocellular-carcinoma-and-promotes-cell-proliferation-by-silencing-klf2
#14
Li Jin, Yangke He, Shijia Tang, Shan Huang
BACKGROUND: Hepatocellular carcinoma (HCC) has been identified as one of the leading causes of cancer-related death worldwide. Recently, long non-coding RNAs (lncRNAs) attract much attention of researchers, and they are demonstrated to be dysregulated in a variety of cancers, including HCC. LncRNA gastric carcinoma high expressed transcript 1 lncRNA GHET1 is found to be dysregulated in gastric cancer (GC). However, its clinical value and potential biological function in HCC remains unclear...
November 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29119116/use-of-limiting-dilution-method-for-isolation-of-nucleus-pulposus-mesenchymal-stem-progenitor-cells-and-effects-of-plating-density-on-biological-characteristics-and-plasticity
#15
Linghan Lin, Zhiwei Jia, Yachao Zhao, Yaohong Wu, Xiyan Zhao, Yong Li, Ziming Guo, Jiahai Chen, Shi Cheng, Deli Wang, Dike Ruan
Objectives: To evaluate the effects of the limiting dilution method and plating density in rat nucleus pulposus mesenchymal stem/progenitor cells (NPMSCs). Materials and Methods: Nucleus pulposus tissues were isolated from 12-week-old male Sprague-Dawley rats and NPMSCs were isolated using limiting dilution method. Cells were then classified into 3 groups according to plating density. Cell morphologies were observed, and colony-forming units, migration abilities, proliferative capacities, cell cycle percentages, multilineage differentiation capacities, stem cell biomarker expression levels, and immunophenotyping were also examined in each group...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29108234/metapristone-ru486-metabolite-suppresses-nsclc-by-targeting-egfr-mediated-pi3k-akt-pathway
#16
Jingwei Shao, Guirong Zheng, Hongning Chen, Jian Liu, Aixiao Xu, Fan Chen, Tao Li, Yusheng Lu, Jianguo Xu, Ning Zheng, Lee Jia
Therapies targeting epidermal growth factor receptor (EGFR) can effectively treat with non-small cell lung cancer (NSCLC), but NSCLC's drug resistance makes it intractable. Herein, we showed that RU486 metabolite metapristone inhibited the proliferation of various NSCLC cell lines with either wild (A549, H1299, H520) or mutated EGFR (H1975, HCC827). The suppression was resulted from inhibition by metapristone of EGFR signaling pathways through down-regulating the EGFR, PTEN, as well as AKT and ERK proteins...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29107862/gypsophila-elegans-isoorientin-2%C3%A2-o-%C3%AE-l-arabinopyranosyl-ameliorates-porcine-serum-induced-immune-liver-fibrosis-by-inhibiting-nf-%C3%AE%C2%BAb-signaling-pathway-and-suppressing-hsc-activation
#17
Facheng Bai, Quanfang Huang, Jinbin Wei, Shujuan Lv, Yuxin Chen, Chunhong Liang, Ling Wei, Zhongpeng Lu, Xing Lin
The present study was to investigate the inhibitory effect of Gypsophila elegans isoorientin-2″-O-α-l-arabinopyranosyl (GEI) on hepatic stellate cells (HSCs), to reveal the underlying mechanism of GEI against hepatic fibrosis. Our study showed that GEI significantly alleviated liver injury induced by porcine serum (PS) in rats; it notably alleviated collagen accumulation as evidenced by a significant decrease in the levels of collagen biomarkers including hyaluronic acid, laminin, hydroxyproline and procollagen III N-terminal peptide...
November 3, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29100325/effects-of-targeting-slc1a5-on-inhibiting-gastric-cancer-growth-and-tumor-development-in-vitro-and-in-vivo
#18
Jian Lu, Min Chen, Zhenhua Tao, Sumeng Gao, Yang Li, Yu Cao, Chun Lu, Xiaoping Zou
Aims: To investigate the oncogenic effects of SLC1A5 on gastric cancer development in vitro and in vivo. Methods: The expression level of SLC1A5 was detected in 70 gastric cancer paraffin-embedded tissues by immunohistochemistry and also was detected in gastric cancer cell lines by qRT-PCR and western blotting analysis. The effects of knockdown SLC1A5 were analyzed on cell proliferation, cell cycle, the ability of cell migration and invasion and growth signaling pathway in vitro...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29073835/mir-9-induces-cell-arrest-and-apoptosis-of-oral-squamous-cell-carcinoma-via-cdk-4-6-pathway
#19
Anquan Shang, Wen-Ying Lu, Man Yang, Cheng Zhou, Hong Zhang, Zheng-Xin Cai, Wei-Wei Wang, Wan-Xiang Wang, Gui-Qi Wu
Oral cancer remains a major public concern with considerable socioeconomic impact in the world, especially in southeast Asia. Despite substantial advancements have been made in treating oral cancer, the five-year survival rate for OSCC remained undesirable, and 35-55% patients developed recurrence within two years even with multimodality therapeutic strategies. Hence, identification of novel biomarkers for diagnosis and evaluating clinical outcome is of vital importance. MicroRNAs are 22-24 nt non-coding RNAs that could bind to 3' UTR of target mRNAs, thereby inducing degradation of mRNA or inhibiting translation...
October 26, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29069776/the-crucial-role-of-srpk1-in-igf-1-induced-emt-of-human-gastric-cancer
#20
Hong Wang, Chunlei Wang, Wenling Tian, Yanfen Yao
In recent years, the insulin-like growth factor (IGF-1) and serine-arginine protein kinase 1 (SRPK1) have been reported to be implicated in the pithelial-mesenchymal transition (EMT) in many kinds of malignancies. However, the potential roles of IGF-1-SRPK1 signaling in the EMT of gastric cancer (GC) have not been investigated. In the present study, the in-vitro assays were used to investigate the molecular role of SRPK1 in cell cycle, motility and invasiveness. We demonstrated that the expressions of SRPK1 or insulin-like growth factor receptor 1 (IGF1R) were significantly increased in GC tissues and cells than those in normal tissues and GES-1 cells, and closely associated with metastasis, stage and prognosis...
September 22, 2017: Oncotarget
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