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https://www.readbyqxmd.com/read/29771367/effectiveness-of-and-user-experience-with-web-based-interventions-in-increasing-physical-activity-levels-in-people-with-multiple-sclerosis-a-systematic-review
#1
Rachel Dennett, Hilary Gunn, Jennifer A Freeman
Background: Supporting people with multiple sclerosis (MS) to achieve and maintain recommended levels of physical activity is important but challenging. Web-based interventions are increasingly being used to deliver targeted exercise programs and promote physical activity. Purpose: The purpose of this study was to systematically review current evidence regarding the effectiveness and user experience of web-based interventions in increasing physical activity in people with MS...
May 15, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29765477/detecting-epileptic-seizure-with-different-feature-extracting-strategies-using-robust-machine-learning-classification-techniques-by-applying-advance-parameter-optimization-approach
#2
Lal Hussain
Epilepsy is a neurological disorder produced due to abnormal excitability of neurons in the brain. The research reveals that brain activity is monitored through electroencephalogram (EEG) of patients suffered from seizure to detect the epileptic seizure. The performance of EEG detection based epilepsy require feature extracting strategies. In this research, we have extracted varying features extracting strategies based on time and frequency domain characteristics, nonlinear, wavelet based entropy and few statistical features...
June 2018: Cognitive Neurodynamics
https://www.readbyqxmd.com/read/29749250/development-and-characterization-of-human-cerebral-organoids-an-optimized-protocol
#3
Abraam M Yakoub, Mark Sadek
Studies of human neurodevelopmental disorders and stem cell-based regenerative transplants have been hampered by the lack of a model of the developing human brain. Stem cell-derived neurons suffer major limitations, including the ability to recapitulate the 3-dimensional architecture of a brain tissue and the representation of multiple layers and cell types that contribute to the overall brain functions in vivo. Recently, cerebral organoid technology was introduced; however, such technology is still in its infancy, and its low reproducibility and limitations significantly reduce the reliability of such a model as it currently exists, especially considering the complexity of cerebral-organoid protocols...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29738326/does-preoperative-enteral-or-parenteral-nutrition-reduce-postoperative-complications-in-crohn-s-disease-patients-a-meta-analysis
#4
Gregory T Brennan, Iris Ha, Christopher Hogan, Emily Nguyen, M M Jamal, Matthew L Bechtold, Douglas L Nguyen
OBJECTIVES: Crohn's disease (CD) patients frequently develop complications that require surgery for management. The high prevalence of malnutrition in CD patients presents a challenge because poor preoperative nutritional status has been shown to increase postoperative complications. In this study, we assessed whether preoperative enteral nutrition (EN) or total parenteral nutrition (TPN) decreases postoperative complications in CD patients. MATERIALS AND METHODS: A three-point systematic and comprehensive literature search was carried out on multiple databases followed by a meta-analysis with results presented as odds ratio (OR) using two models, the Mantel-Haenszel model and the DerSimonian and Laird model...
May 7, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29723198/telesonography-in-emergency-medicine-a-systematic-review
#5
Genevieve Marsh-Feiley, Leila Eadie, Philip Wilson
Ultrasound is an efficacious, versatile and affordable imaging technique in emergencies, but has limited utility without expert interpretation. Telesonography, in which experts may remotely support the use of ultrasound through a telecommunications link, may broaden access to ultrasound and improve patient outcomes, particularly in remote settings. This review assesses the literature regarding telesonography in emergency medicine, focussing on evidence of feasibility, diagnostic accuracy and clinical utility...
2018: PloS One
https://www.readbyqxmd.com/read/29723027/sex-differences-in-ptsd-symptoms-a-differential-item-functioning-approach
#6
Siobhan Murphy, Ask Elklit, Yoke Yong Chen, Siti Raudzah Ghazali, Mark Shevlin
OBJECTIVE: Evidence has suggested there are sex differences in posttraumatic stress disorder (PTSD) symptom expression; however, few studies have assessed whether these differences are due to measurement invariance. This study aimed to examine sex differences in PTSD symptoms based on the Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) using differential item functioning (DIF). METHOD: Confirmatory factor analysis was conducted on the DSM-5 model of PTSD, followed by a multiple indicators multiple causes (MIMIC) model to examine possible DIF using the PTSD Checklist for DSM-5...
May 3, 2018: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/29721499/predictors-of-broad-dimensions-of-psychopathology-among-patients-with-panic-disorder-after-cognitive-behavioral-therapy
#7
Sei Ogawa, Masaki Kondo, Keiko Ino, Risa Imai, Toshitaka Ii, Toshi A Furukawa, Tatsuo Akechi
Background: Many patients with panic disorder meet criteria for at least one other diagnosis, most commonly other anxiety or mood disorders. Cognitive-behavioral therapy is the best empirically supported psychotherapy for panic disorder. There is now evidence indicating that cognitive-behavioral therapy for panic disorder yields positive benefits upon comorbid disorders. Objectives: The present study aimed to examine the predictors of broad dimensions of psychopathology in panic disorder after cognitive-behavioral therapy...
2018: Psychiatry Journal
https://www.readbyqxmd.com/read/29718449/cross-site-reliability-of-human-induced-pluripotent-stem-cell-derived-cardiomyocyte-based-safety-assays-using-microelectrode-arrays-results-from-a-blinded-cipa-pilot-study
#8
Daniel Millard, Qianyu Dang, Hong Shi, Xiaou Zhang, Chris Strock, Udo Kraushaar, Haoyu Zeng, Paul Levesque, Hua-Rong Lu, Jean-Michel Guillon, Joseph C Wu, Yingxin Li, Greg Luerman, Blake Anson, Liang Guo, Mike Clements, Yama A Abassi, James Ross, Jennifer Pierson, Gary Gintant
Recent in vitro cardiac safety studies demonstrate the ability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to detect electrophysiologic effects of drugs. However, variability contributed by unique approaches, procedures, cell lines and reagents across laboratories makes comparisons of results difficult, leading to uncertainty about the role of hiPSC-CMs in defining proarrhythmic risk in drug discovery and regulatory submissions. A blinded pilot study was conducted to evaluate the electrophysiologic effects of eight well-characterized drugs on four cardiomyocyte lines using a standardized protocol across three microelectrode array (MEA) platforms (18 individual studies)...
April 27, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29710121/association-of-retinal-ganglion-cell-layer-thickness-with-future-disease-activity-in-patients-with-clinically-isolated-syndrome
#9
Hanna G Zimmermann, Benjamin Knier, Timm Oberwahrenbrock, Janina Behrens, Catherina Pfuhl, Lilian Aly, Miriam Kaminski, Muna-Miriam Hoshi, Svenja Specovius, René M Giess, Michael Scheel, Mark Mühlau, Judith Bellmann-Strobl, Klemens Ruprecht, Bernhard Hemmer, Thomas Korn, Friedemann Paul, Alexander U Brandt
Importance: Clinically isolated syndrome (CIS) describes a first clinical incident suggestive of multiple sclerosis (MS). Identifying patients with CIS who have a high risk of future disease activity and subsequent MS diagnosis is crucial for patient monitoring and the initiation of disease-modifying therapy. Objective: To investigate the association of retinal optical coherence tomography (OCT) results with future disease activity in patients with CIS. Design, Setting, and Participants: This prospective, longitudinal cohort study took place between January 2011 and May 2017 at 2 German tertiary referral centers...
April 23, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29700755/does-non-adherence-increase-treatment-costs-in-schizophrenia
#10
REVIEW
Mark Pennington, Paul McCrone
INTRODUCTION: Medication non-adherence is a serious barrier to treatment of schizophrenia. Understanding the impact of non-adherence on costs is essential to the assessment of the cost effectiveness of interventions in which adherence to treatment is a concern. OBJECTIVES: We undertook a comprehensive review of the available literature on the impact on costs of non-adherence to antipsychotics in the treatment of schizophrenia. METHODS: We performed a search on multiple databases (MEDLINE, Embase, PsycINFO and Health Management Information Consortium) for any study reporting the impact of adherence to antipsychotics on costs in patients with schizophrenia up to February 2018...
April 26, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29697214/sickle-cell-anaemia-and-the-experiences-of-young-people-living-with-the-condition
#11
Nicole Foster, Michelle Ellis
Sickle cell anaemia (SCA) is a life-threatening haemoglobin disorder acknowledged for its unpredictability and painful episodes. The aim of this qualitative literature review was to explore the experiences of young people living with SCA and its effect on their lives. The objective was to critically review selected primary research and make recommendations for practice, education and research. After reviewing potential articles using EBSCOhost, inclusion and exclusion criteria were devised and six appropriate studies were found with most participants in the 10-25 years age range...
April 26, 2018: Nursing Children and Young People
https://www.readbyqxmd.com/read/29695941/a-naturalistic-study-on-the-relationship-among-resilient-factors-psychiatric-symptoms-and-psychosocial-functioning-in-a-sample-of-residential-patients-with-psychosis
#12
Nicola Poloni, Daniele Zizolfi, Marta Ielmini, Roberto Pagani, Ivano Caselli, Marcello Diurni, Anna Milano, Camilla Callegari
Objective: Resilience is a multidimensional process of adaptation aimed to overcome stressful or traumatic life experiences; only in the last few years it has been considered as a personal resource in psychosis and schizophrenia. This study aimed to assess the relationship between intrapersonal and interpersonal resilience factors and schizophrenia, particularly whether and how resilience can improve the course of psychotic illness. Patients and methods: In this observational study, all patients recruited had to fulfill the following inclusion criteria: diagnosis of schizophrenia spectrum disorder ( Diagnostic and Statistical Manual of Mental Disorders-5 ); aged between 18 and 65 years; provided written informed consent; to be clinically stable (Clinical Global Impression Scale <3); history of illness ≥5 years; to be compliant with antipsychotic therapy over the last year; and regular submission to periodic monthly psychiatric visits...
2018: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/29679359/the-impact-of-national-policies-on-animal-disease-reporting-within-selected-pacific-island-countries-and-territories-picts
#13
Andrew Tukana, Robert Hedlefs, Bruce Gummow
A semi-systematic literature review of national policies was carried out in relation to surveillance and disease reporting in Pacific Island Countries and Territories (PICTs). It also analysed the animal disease reporting structures in Fiji, Papua New Guinea (PNG), Vanuatu and the Solomon Islands. The strengths, weaknesses, opportunities and threats (SWOT) of those reporting structures were examined in relation to how they impacted the detection and management of animal diseases in PICTs. Field missions collected information on animal disease reporting structures and these were discussed in detail with country officials and documented...
April 20, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29666883/snp-based-pool-genotyping-and-haplotype-analysis-accelerate-fine-mapping-of-the-wheat-genomic-region-containing-stripe-rust-resistance-gene-yr26
#14
Jianhui Wu, Qingdong Zeng, Qilin Wang, Shengjie Liu, Shizhou Yu, Jingmei Mu, Shuo Huang, Hanan Sela, Assaf Distelfeld, Lili Huang, Dejun Han, Zhensheng Kang
NGS-assisted super pooling emerging as powerful tool to accelerate gene mapping and haplotype association analysis within target region uncovering specific linkage SNPs or alleles for marker-assisted gene pyramiding. Conventional gene mapping methods to identify genes associated with important agronomic traits require significant amounts of financial support and time. Here, a single nucleotide polymorphism (SNP)-based mapping approach, RNA-Seq and SNP array assisted super pooling analysis, was used for rapid mining of a candidate genomic region for stripe rust resistance gene Yr26 that has been widely used in wheat breeding programs in China...
April 17, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29659826/association-between-ambient-air-pollution-and-pregnancy-rate-in-women-who-underwent-ivf
#15
S A Choe, Y B Jun, W S Lee, T K Yoon, S Y Kim
STUDY QUESTION: Are the concentrations of five criteria air pollutants associated with probabilities of biochemical pregnancy loss and intrauterine pregnancy in women? SUMMARY ANSWER: Increased concentrations of ambient particulate matter (PM10), nitrogen dioxide (NO2), carbon monoxide (CO) during controlled ovarian stimulation (COS) and after embryo transfer were associated with a decreased probability of intrauterine pregnancy. WHAT IS KNOWN ALREADY: Exposure to high ambient air pollution was suggested to be associated with low fertility and high early pregnancy loss in women...
April 5, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29649899/managers-support-for-employee-wellness-programs-an-integrative-review
#16
Deborah G Passey, Meagan C Brown, Kristen Hammerback, Jeffrey R Harris, Peggy A Hannon
OBJECTIVE: The aim of this integrative literature review is to synthesize the existing evidence regarding managers' support for employee wellness programs. DATA SOURCE: The search utilized multiple electronic databases and libraries. STUDY INCLUSION AND EXCLUSION CRITERIA: Inclusion criteria comprised peer-reviewed research published in English, between 1990 and 2016, and examining managers' support in the context of a worksite intervention...
January 1, 2018: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29625768/human-papillomavirus-vaccine-acceptability-and-decision-making-among-adolescent-boys-and-parents-a-meta-ethnography-of-qualitative-studies
#17
REVIEW
Ashley Lacombe-Duncan, Peter A Newman, Philip Baiden
OBJECTIVE: Genital warts and human papillomavirus (HPV)-associated cancers in men can be substantially reduced through HPV vaccination; yet, globally, HPV vaccine uptake among boys remains low. This meta-ethnography synthesizes qualitative studies to understand, in-depth, HPV vaccine acceptability and decision-making among adolescent boys and/or their parents. METHODS: A systematic search identified qualitative studies examining HPV vaccines from the perspectives of boys and/or boys' parents...
April 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29621583/a-review-of-the-traditional-use-of-southern-african-medicinal-plants-for-the-treatment-of-selected-parasite-infections-affecting-humans
#18
REVIEW
I E Cock, M I Selesho, S F van Vuuren
ETHNOPHARMACOLOGICAL RELEVANCE: Worldwide, more than three billion cases of parasitic disease are reported yearly and it is likely that this figure is substantially under-estimated. Approximately one in six people globally are estimated to be infected with at least one parasite species annually. In South Africa, the prevalence of Schistosoma haematobium (bilharzia) and intestinal worms and helminths are particularly high, especially in children and in crowded or poorer rural communities with inadequate sanitation and nutritional status...
April 2, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29606521/pharmacological-therapy-selection-of-type-2-diabetes-based-on-the-swara-and-modified-multimoora-methods-under-a-fuzzy-environment
#19
M Eghbali-Zarch, R Tavakkoli-Moghaddam, F Esfahanian, M M Sepehri, A Azaron
Medication selection for Type 2 Diabetes (T2D) is a challenging medical decision-making problem involving multiple medications that can be prescribed to control the patient's blood glucose. The wide range of hyperglycemia lowering agents with varying effects and various side effects makes the decision quite difficult. This paper presents computer-aided medical decision support using a fuzzy Multi-Criteria Decision-Making (MCDM) model that hybridizes a Step-wise Weight Assessment Ratio Analysis (SWARA) method with a modification of Fuzzy Multi-Objective Optimization on the basis of a Ratio Analysis plus the full multiplicative form (FMULTIMOORA) method for pharmacological therapy selection of T2D...
March 29, 2018: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29598981/factors-influencing-men-s-choice-of-and-adherence-to-active-surveillance-for-low-risk-prostate-cancer-a-mixed-method-systematic-review
#20
REVIEW
Netty Kinsella, Pär Stattin, Declan Cahill, Christian Brown, Anna Bill-Axelson, Ola Bratt, Sigrid Carlsson, Mieke Van Hemelrijck
CONTEXT: Despite support for active surveillance (AS) as a first treatment choice for men with low-risk prostate cancer (PC), this strategy is largely underutilised. OBJECTIVE: To systematically review barriers and facilitators to selecting and adhering to AS for low-risk PC. EVIDENCE ACQUISITION: We searched PsychINFO, PubMed, Medline 2000-now, Embase, CINAHL, and Cochrane Central databases between 2002 and 2017 using the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement...
March 26, 2018: European Urology
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