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Multiple criteria support analysis

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https://www.readbyqxmd.com/read/29142047/multi-center-evaluation-of-the-vitek-ms-v3-0-system-for-the-identification-of-filamentous-fungi
#1
Jenna Rychert, E Sue Slechta, Adam P Barker, Edwin Miranda, N Esther Babady, Yi-Wei Tang, Connie Gibas, Nathan Wiederhold, DeAnna Sutton, Kimberly E Hanson
Invasive fungal infections are an important cause of morbidity and mortality affecting primarily immunocompromised patients. While fungal identification to the species level is critical to providing appropriate therapy, it can be slow, laborious, and often relies on subjective morphologic criteria. The use of MALDI-TOF mass spectrometry has the potential to speed up and improve the accuracy of identification. In this multi-center study, we evaluated the accuracy of the VITEK® MS v3.0 system in identifying 1,601 clinical mold isolates as compared to identification by DNA sequence analysis and supported by morphologic and phenotypic testing...
November 15, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29122796/association-between-organisational-and-workplace-cultures-and-patient-outcomes-systematic-review
#2
Jeffrey Braithwaite, Jessica Herkes, Kristiana Ludlow, Luke Testa, Gina Lamprell
DESIGN AND OBJECTIVES: Every organisation has a unique culture. There is a widely held view that a positive organisational culture is related to positive patient outcomes. Following the Preferred Reporting Items for Systematic Review and Meta-Analyses statement, we systematically reviewed and synthesised the evidence on the extent to which organisational and workplace cultures are associated with patient outcomes. SETTING: A variety of healthcare facilities, including hospitals, general practices, pharmacies, military hospitals, aged care facilities, mental health and other healthcare contexts...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29117789/nlrp3-polymorphisms-and-response-to-interferon-beta-in-multiple-sclerosis-patients
#3
Sunny Malhotra, Melissa Sorosina, Jordi Río, Silvia Peroni, Luciana Midaglia, Luisa M Villar, José C Álvarez-Cermeño, Ina Schroeder, Federica Esposito, Ferdinando Clarelli, Uwe K Zettl, Jeannette Lechner-Scott, Nino Spataro, Arcadi Navarro, Giancarlo Comi, Xavier Montalban, Filippo Martinelli-Boneschi, Manuel Comabella
We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms...
November 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29113522/who-uses-apps-in-health-promotion-a-target-group-analysis-of-leaders
#4
Anita Bregenzer, Verena Wagner-Hartl, Paul Jiménez
User characteristics should be considered when designing features for e-health or m-health applications, as the developed solution should aim to support this specific target group. This study explores the effect of user characteristics (personality, health state, stress/recovery state, leadership behavior) on the interest and likelihood of using an app for health promotion activities at the workplace. Leaders are a key factor for the success of workplace health promotion; therefore, the target group of this study are leaders...
November 1, 2017: Health Informatics Journal
https://www.readbyqxmd.com/read/29081919/utilization-of-multiple-criteria-decision-analysis-mcda-to-support-healthcare-decision-making-fifarma-2016
#5
Julia I Drake, Juan Carlos Trujillo de Hart, Clara Monleón, Walter Toro, Joice Valentim
Background and objectives:   MCDA is a decision-making tool with increasing use in the healthcare sector, including HTA (Health Technology Assessment). By applying multiple criteria, including innovation, in a comprehensive, structured and explicit manner, MCDA fosters a transparent, participative, consistent decision-making process taking into consideration values of all stakeholders. This paper by FIFARMA (Latin American Federation of Pharmaceutical Industry) proposes the deliberative (partial) MCDA as a more pragmatic, agile approach, especially when newly implemented...
2017: Journal of Market Access & Health Policy
https://www.readbyqxmd.com/read/29076244/intersecting-disadvantage-unpacking-poor-outcomes-within-early-intervention-in-psychosis-services
#6
Nev Jones, Julia Godzikovskaya, Zhen Zhao, Anthony Vasquez, Al Gilbert, Larry Davidson
AIM: In order to strengthen specialized early intervention in psychosis (EIP) services, a contextually nuanced understanding of psychosocial forces driving suboptimal treatment response is critical. This study sought to examine factors driving poor outcomes through a systematic emic coding of psychosocial assessments for discharged EIP clients categorized as leaving with all treatment goals met (AG) or no treatment goals met (NG). METHODS: Psychosocial assessments at baseline, 1 year, 2 years and discharge were extracted from an EIP research registry and systematically coded...
October 27, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29075125/conduits-to-care-call-lights-and-patients-perceptions-of-communication
#7
Mary Montie, Clayton Shuman, Jose Galinato, Lance Patak, Christine A Anderson, Marita G Titler
BACKGROUND: Call light systems remain the primary means of hospitalized patients to initiate communication with their health care providers. Although there is vast amounts of literature discussing patient communication with their health care providers, few studies have explored patients' perceptions concerning call light use and communication. The specific aim of this study was to solicit patients' perceptions regarding their call light use and communication with nursing staff. METHODS: Patients invited to this study met the following inclusion criteria: proficient in English, been hospitalized for at least 24 hours, aged ≥21 years, and able to communicate verbally (eg, not intubated)...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/29057290/feature-analysis-of-cell-nuclear-chromatin-distribution-in-support-of-cervical-cytology
#8
Hideki Komagata, Takaya Ichimura, Yasuka Matsuta, Masahiro Ishikawa, Kazuma Shinoda, Naoki Kobayashi, Atsushi Sasaki
Cytology, a method of estimating cancer or cellular atypia from microscopic images of scraped specimens, is used according to the pathologist's experience to diagnose cases based on the degree of structural changes and atypia. Several methods of cell feature quantification, including nuclear size, nuclear shape, cytoplasm size, and chromatin texture, have been studied. We focus on chromatin distribution in the cell nucleus and propose new feature values that indicate the chromatin complexity, spreading, and bias, including convex hull ratio on multiple binary images, intensity distribution from the gravity center, and tangential component intensity and texture biases...
October 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29055459/smoking-and-multiple-sclerosis-a-systematic-review-and-meta-analysis-using-the-bradford-hill-criteria-for-causation
#9
REVIEW
Michelle L Degelman, Katya M Herman
BACKGROUND: Despite being one of the most common neurological disorders globally, the cause(s) of multiple sclerosis (MS) remain unknown. Cigarette smoking has been studied with regards to both the development and progression of MS. The Bradford Hill criteria for causation can contribute to a more comprehensive evaluation of a potentially causal risk factor-disease outcome relationship. The objective of this systematic review and meta-analysis was to assess the relationship between smoking and both MS risk and MS progression, subsequently applying Hill's criteria to further evaluate the likelihood of causal associations...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29045857/a-systematic-review-and-meta-analysis-on-the-use-of-repetitive-transcranial-magnetic-stimulation-for-spasticity-post-stroke
#10
REVIEW
A McIntyre, M Mirkowski, S Thompson, A M Burhan, T Miller, R Teasell
BACKGROUND: Spasticity is a common and potentially debilitating complication that develops after stroke, arising in approximately 30% of patients. OBJECTIVE: To evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in improving spasticity after stroke. DESIGN: Meta-analysis and systematic review. SETTING: N/A PATIENTS: A total of 273 post-stroke (hemorrhagic=123, ischemic=150) participants were included with sample sizes ranging from 5 to 80...
October 15, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29025839/family-attitudes-actions-decisions-and-experiences-following-implementation-of-deemed-consent-and-the-human-transplantation-wales-act-2013-mixed-method-study-protocol
#11
Jane Noyes, Karen Morgan, Phillip Walton, Abigail Roberts, Leah Mclaughlin, Michael Stephens
INTRODUCTION: The Human Transplantation (Wales) Act 2013 (the Act) introduced a 'soft opt-out' system of organ donation on 1 December 2015. Citizens are encouraged to make their organ donation decision known during their lifetime. In order to work, the Act and media campaign need to create a context, whereby organ donation becomes the norm, and create a mechanism for people to behave as intended (formally register their decision; consider appointing a representative; convey their donation decision to their families and friends or do nothing-deemed consent)...
October 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29022539/bibliometric-trends-of-south-african-environmental-health-articles-between-1998-and-2015-making-local-research-visible-and-retrievable
#12
C Y Wright, F Dominick, Z Kunene, T Kapwata, R A Street
BACKGROUND: South Africa (SA) has to grapple with multiple burdens of disease for which environmental factors have a role to play in both causation and prevention. This article describes a bibliometric review of environmental health indexed literature for SA over an 18-year period. OBJECTIVES: To provide an overview of the nature of SA-based published environmental health indexed research and to identify search challenges, frequently researched topics, and gaps and opportunities for future research...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28988642/risk-of-beta-cell-autoimmunity-presence-for-progression-to-type-1-diabetes-a-systematic-review-and-meta-analysis
#13
REVIEW
Qing Ling, Jing Lu, Jingjing Li, Qianyue Xu, Dalong Zhu, Yan Bi
BACKGROUND: Islet autoantibodies have been applied for diagnosis of type 1 diabetes mellitus (T1DM) at an asymptomatic stage in individuals with high-risk genotypes. Evidence is insufficient to support a broad application of islet autoantibody screening for T1DM in clinical practice. The aim of this study was to assess the evidence of an association between islet autoantibodies and the development of T1DM in a pooled population of both genetically at-risk individuals and general people without definite genetic background...
October 5, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28981654/temporal-trends-in-sperm-count-a-systematic-review-and-meta-regression-analysis
#14
Hagai Levine, Niels Jørgensen, Anderson Martino-Andrade, Jaime Mendiola, Dan Weksler-Derri, Irina Mindlis, Rachel Pinotti, Shanna H Swan
BACKGROUND: Reported declines in sperm counts remain controversial today and recent trends are unknown. A definitive meta-analysis is critical given the predictive value of sperm count for fertility, morbidity and mortality. OBJECTIVE AND RATIONALE: To provide a systematic review and meta-regression analysis of recent trends in sperm counts as measured by sperm concentration (SC) and total sperm count (TSC), and their modification by fertility and geographic group...
November 1, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28960689/point-of-care-cognitive-support-technology-in-emergency-departments-a-scoping-review-of-technology-acceptance-by-clinicians
#15
Shelly Jun, Amy C Plint, Sandy M Campbell, Sarah Curtis, Kyrellos Sabir, Amanda S Newton
OBJECTIVE: Cognitive support technologies that support clinical decisions and practices in the emergency department (ED) have the potential to optimize patient care. However, limited uptake by clinicians can prevent successful implementation. A better understanding of acceptance of these technologies from the clinician perspective is needed. We conducted a scoping review to synthesize diverse, emerging evidence on clinicians' acceptance of point-of-care (POC) cognitive support technology in the ED...
September 28, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28934777/effectiveness-of-thermal-annular-procedures-in-treating-discogenic-low-back-pain
#16
Standiford Helm Ii, Thomas T Simopoulos, Milan Stojanovic, Salahadin Abdi, Mohamed Ahamed El Terany
BACKGROUND: Discogenic low back is a distinct clinic entity characterized by pain arising from a damaged disc. The diagnosis is clouded by the controversy surrounding discography. The treatment options are limited, with unsatisfactory results from both conservative treatment and surgery. Multiple interventional therapies have been developed to treat discogenic pain, but most have not yet been validated by high quality studies.The best studied treatment for discogenic pain is the use of heat, which has been labeled as thermal intradiscal procedures (TIPs) by the Centers for Medicare and Medicaid Services (CMS)...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28914229/clinical-effectiveness-and-cost-effectiveness-of-beta-interferon-and-glatiramer-acetate-for-treating-multiple-sclerosis-systematic-review-and-economic-evaluation
#17
G J Melendez-Torres, Peter Auguste, Xavier Armoiry, Hendramoorthy Maheswaran, Rachel Court, Jason Madan, Alan Kan, Stephanie Lin, Carl Counsell, Jacoby Patterson, Jeremy Rodrigues, Olga Ciccarelli, Hannah Fraser, Aileen Clarke
BACKGROUND: At the time of publication of the most recent National Institute for Health and Care Excellence (NICE) guidance [technology appraisal (TA) 32] in 2002 on beta-interferon (IFN-β) and glatiramer acetate (GA) for multiple sclerosis, there was insufficient evidence of their clinical effectiveness and cost-effectiveness. OBJECTIVES: To undertake (1) systematic reviews of the clinical effectiveness and cost-effectiveness of IFN-β and GA in relapsing-remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS) and clinically isolated syndrome (CIS) compared with best supportive care (BSC) and each other, investigating annualised relapse rate (ARR) and time to disability progression confirmed at 3 months and 6 months and (2) cost-effectiveness assessments of disease-modifying therapies (DMTs) for CIS and RRMS compared with BSC and each other...
September 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28910496/using-blogs-to-explore-the-lived-experience-of-life-after-stroke-a-journey-of-discovery-i-never-wanted-to-take
#18
Caroline M Thomas, Rhoda Allison, Jos M Latour
AIMS: To explore the lived-experiences of stroke survivors as expressed in blogs and to discover the role the blogs play in the writers' lives. BACKGROUND: Stroke can be a devastating, life changing event. Previous qualitative studies tend to examine one aspect of life after stroke. As stroke often has multiple effects, it is necessary to look widely at its lived-experience. New resources which can enable researchers to explore the lived-experience of stroke are blogs...
September 14, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28903117/the-mortality-and-myocardial-effects-of-antidepressants-are-moderated-by-preexisting-cardiovascular-disease-a-meta-analysis
#19
Marta M Maslej, Benjamin M Bolker, Marley J Russell, Keifer Eaton, Zachary Durisko, Steven D Hollon, G Marie Swanson, J Anderson Thomson, Benoit H Mulsant, Paul W Andrews
BACKGROUND: Antidepressants (ADs) are commonly prescribed medications, but their long-term health effects are debated. ADs disrupt multiple adaptive processes regulated by evolutionarily ancient biochemicals, potentially increasing mortality. However, many ADs also have anticlotting properties that can be efficacious in treating cardiovascular disease. We conducted a meta-analysis assessing the effects of ADs on all-cause mortality and cardiovascular events in general-population and cardiovascular-patient samples...
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28901165/lc-ms-ms-analysis-of-lipidized-analogs-of-prolactin-releasing-peptide-utilizing-a-monolithic-column-and-simple-sample-preparation
#20
Jana Zemenová, David Sýkora, Anna Freislebenová, Lenka Maletínská
AIM: Novel compounds for obesity treatment are currently being studied employing lipidized analogs of anorexigenic neuropeptides. Various analogs of prolactin-releasing peptide have demonstrated their ability to decrease food intake. Adequate analytical tools are required to support corresponding research. Methodology & results: An analytical method was developed that includes simple dilution of plasma samples prior to liquid chromatography-mass spectrometry and employs a monolithic column for the determination of lipidized analogs of prolactin-releasing peptide in complex biological samples...
September 13, 2017: Bioanalysis
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