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https://www.readbyqxmd.com/read/28934777/effectiveness-of-thermal-annular-procedures-in-treating-discogenic-low-back-pain
#1
Standiford Helm Ii, Thomas T Simopoulos, Milan Stojanovic, Salahadin Abdi, Mohamed Ahamed El Terany
BACKGROUND: Discogenic low back is a distinct clinic entity characterized by pain arising from a damaged disc. The diagnosis is clouded by the controversy surrounding discography. The treatment options are limited, with unsatisfactory results from both conservative treatment and surgery. Multiple interventional therapies have been developed to treat discogenic pain, but most have not yet been validated by high quality studies.The best studied treatment for discogenic pain is the use of heat, which has been labeled as thermal intradiscal procedures (TIPs) by the Centers for Medicare and Medicaid Services (CMS)...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28914229/clinical-effectiveness-and-cost-effectiveness-of-beta-interferon-and-glatiramer-acetate-for-treating-multiple-sclerosis-systematic-review-and-economic-evaluation
#2
G J Melendez-Torres, Peter Auguste, Xavier Armoiry, Hendramoorthy Maheswaran, Rachel Court, Jason Madan, Alan Kan, Stephanie Lin, Carl Counsell, Jacoby Patterson, Jeremy Rodrigues, Olga Ciccarelli, Hannah Fraser, Aileen Clarke
BACKGROUND: At the time of publication of the most recent National Institute for Health and Care Excellence (NICE) guidance [technology appraisal (TA) 32] in 2002 on beta-interferon (IFN-β) and glatiramer acetate (GA) for multiple sclerosis, there was insufficient evidence of their clinical effectiveness and cost-effectiveness. OBJECTIVES: To undertake (1) systematic reviews of the clinical effectiveness and cost-effectiveness of IFN-β and GA in relapsing-remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS) and clinically isolated syndrome (CIS) compared with best supportive care (BSC) and each other, investigating annualised relapse rate (ARR) and time to disability progression confirmed at 3 months and 6 months and (2) cost-effectiveness assessments of disease-modifying therapies (DMTs) for CIS and RRMS compared with BSC and each other...
September 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28910496/using-blogs-to-explore-the-lived-experience-of-life-after-stroke-a-journey-of-discovery-i-never-wanted-to-take
#3
Caroline M Thomas, Rhoda Allison, Jos M Latour
AIMS: To explore the lived-experiences of stroke survivors as expressed in blogs and to discover the role the blogs play in the writers' lives. BACKGROUND: Stroke can be a devastating, life changing event. Previous qualitative studies tend to examine one aspect of life after stroke. As stroke often has multiple effects it is necessary to look widely at its lived-experience. New resources which can enable researchers to explore the lived-experience of stroke are blogs...
September 14, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28903117/the-mortality-and-myocardial-effects-of-antidepressants-are-moderated-by-preexisting-cardiovascular-disease-a-meta-analysis
#4
Marta M Maslej, Benjamin M Bolker, Marley J Russell, Keifer Eaton, Zachary Durisko, Steven D Hollon, G Marie Swanson, J Anderson Thomson, Benoit H Mulsant, Paul W Andrews
BACKGROUND: Antidepressants (ADs) are commonly prescribed medications, but their long-term health effects are debated. ADs disrupt multiple adaptive processes regulated by evolutionarily ancient biochemicals, potentially increasing mortality. However, many ADs also have anticlotting properties that can be efficacious in treating cardiovascular disease. We conducted a meta-analysis assessing the effects of ADs on all-cause mortality and cardiovascular events in general-population and cardiovascular-patient samples...
September 14, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28901165/lc-ms-ms-analysis-of-lipidized-analogs-of-prolactin-releasing-peptide-utilizing-a-monolithic-column-and-simple-sample-preparation
#5
Jana Zemenová, David Sýkora, Anna Freislebenová, Lenka Maletínská
AIM: Novel compounds for obesity treatment are currently being studied employing lipidized analogs of anorexigenic neuropeptides. Various analogs of prolactin-releasing peptide have demonstrated their ability to decrease food intake. Adequate analytical tools are required to support corresponding research. Methodology & results: An analytical method was developed that includes simple dilution of plasma samples prior to liquid chromatography-mass spectrometry and employs a monolithic column for the determination of lipidized analogs of prolactin-releasing peptide in complex biological samples...
September 13, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28899444/use-of-implementation-science-for-a-sustained-reduction-of-central-line-associated-bloodstream-infections-in-a-high-volume-regional-burn-unit
#6
Geeta Sood, Julie Caffrey, Kelly Krout, Zeina Khouri-Stevens, Kevin Gerold, Stefan Riedel, Janet McIntyre, Lisa L Maragakis, Renee Blanding, Jonathan Zenilman, Richard Bennett, Peter Pronovost
OBJECTIVE We describe the use of implementation science at the unit level and organizational level to guide an intervention to reduce central-line-associated bloodstream infections (CLABSIs) in a high-volume, regional, burn intensive care unit (BICU). DESIGN A single center observational quasi-experimental study. SETTING A regional BICU in Maryland serving 300-400 burn patients annually. INTERVENTIONS In 2011, an organizational-level and unit-level intervention was implemented to reduce the rates of CLABSI in a high-risk patient population in the BICU...
September 13, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28887759/factors-contributing-to-chronic-ankle-instability-a-systematic-review-and-meta-analysis-of-systematic-reviews
#7
REVIEW
Cassandra Thompson, Siobhan Schabrun, Rick Romero, Andrea Bialocerkowski, Jaap van Dieen, Paul Marshall
BACKGROUND: Many factors are thought to contribute to chronic ankle instability (CAI). Multiple systematic reviews have synthesised the available evidence to identify the primary contributing factors. However, readers are now faced with several systematic reviews that present conflicting findings. OBJECTIVE: The aim of this systematic review and meta-analysis was to establish the statistical significance and effect size of primary factors contributing to CAI and to identify likely reasons for inconsistencies in the literature...
September 8, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28887746/diagnosis-of-multiple-sclerosis-from-eeg-signals-using-nonlinear-methods
#8
Ali Torabi, Mohammad Reza Daliri, Seyyed Hojjat Sabzposhan
EEG signals have essential and important information about the brain and neural diseases. The main purpose of this study is classifying two groups of healthy volunteers and Multiple Sclerosis (MS) patients using nonlinear features of EEG signals while performing cognitive tasks. EEG signals were recorded when users were doing two different attentional tasks. One of the tasks was based on detecting a desired change in color luminance and the other task was based on detecting a desired change in direction of motion...
September 8, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28887251/metabolic-syndrome-but-not-obesity-adversely-affects-outcomes-after-open-aortoiliac-bypass-surgery
#9
Akiko Tanaka, Alexa Perlick, Charles C Miller, Harleen K Sandhu, Shaikh Afaq, Hazim J Safi, Ali Azizzadeh, Kristofer M Charlton-Ouw
OBJECTIVE: Although the incident risk of peripheral artery disease increases in patients with metabolic syndrome, several authors report favorable outcomes in obese patients after arterial bypass surgery. We examine the effect of the so-called "obesity paradox" and metabolic syndrome on outcomes after open aortoiliac bypass surgery. METHODS: We identified patients between 2004 and 2015 who had open surgical bypass for aortoiliac occlusive disease. We excluded patients with endovascular repair and those treated primarily for aneurysmal disease...
September 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28886562/support-of-supervised-injection-facilities-by-emergency-physicians-in-canada
#10
Noam Katz, Lynne Leonard, Lorne Wiesenfeld, Jeffrey J Perry, Venkatesh Thiruganasambandamoorthy, Lisa Calder
BACKGROUND: Despite evidence supporting the implementation of supervised injection facilities (SIFs) by multiple stakeholders, no evaluation of emergency physicians' attitudes has ever been documented towards such facilities in Canada or internationally. The primary goal of our study was to determine the opinions and perceptions of emergency physicians regarding the implementation of SIFs in Canada. METHODS: We conducted a national electronic survey of staff and resident emergency physicians in Canada using an iteratively designed survey tool in consultation with content experts...
September 5, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28878778/multivariate-analysis-as-a-support-for-diagnostic-flowcharts-in-allergic-bronchopulmonary-aspergillosis-a-proof-of-concept-study
#11
Joana Vitte, Stéphane Ranque, Ania Carsin, Carine Gomez, Thomas Romain, Carole Cassagne, Marion Gouitaa, Mélisande Baravalle-Einaudi, Nathalie Stremler-Le Bel, Martine Reynaud-Gaubert, Jean-Christophe Dubus, Jean-Louis Mège, Jean Gaudart
Molecular-based allergy diagnosis yields multiple biomarker datasets. The classical diagnostic score for allergic bronchopulmonary aspergillosis (ABPA), a severe disease usually occurring in asthmatic patients and people with cystic fibrosis, comprises succinct immunological criteria formulated in 1977: total IgE, anti-Aspergillus fumigatus (Af) IgE, anti-Af "precipitins," and anti-Af IgG. Progress achieved over the last four decades led to multiple IgE and IgG(4) Af biomarkers available with quantitative, standardized, molecular-level reports...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28877196/predicting-active-layer-soil-thickness-using-topographic-variables-at-a-small-watershed-scale
#12
Aidi Li, Xing Tan, Wei Wu, Hongbin Liu, Jie Zhu
Knowledge about the spatial distribution of active-layer (AL) soil thickness is indispensable for ecological modeling, precision agriculture, and land resource management. However, it is difficult to obtain the details on AL soil thickness by using conventional soil survey method. In this research, the objective is to investigate the possibility and accuracy of mapping the spatial distribution of AL soil thickness through random forest (RF) model by using terrain variables at a small watershed scale. A total of 1113 soil samples collected from the slope fields were randomly divided into calibration (770 soil samples) and validation (343 soil samples) sets...
2017: PloS One
https://www.readbyqxmd.com/read/28874330/comparison-of-rifle-akin-and-kdigo-classifications-for-assessing-prognosis-of-patients-on-extracorporeal-membrane-oxygenation
#13
Tsung-Yu Tsai, Hao Chien, Feng-Chun Tsai, Heng-Chih Pan, Huang-Yu Yang, Shen-Yang Lee, Hsiang-Hao Hsu, Ji-Tseng Fang, Chih-Wei Yang, Yung-Chang Chen
BACKGROUND/PURPOSE: Acute kidney injury (AKI) developing during extracorporeal membrane oxygenation (ECMO) is associated with very poor outcome. The Kidney Disease: Improving Global Outcomes (KDIGO) group published a new AKI definition in 2012. This study analyzed the outcomes of patients treated with ECMO and identified the relationship between the prognosis and the KDIGO classification. METHODS: This study examined total 312 patients initially, and finally reviewed the medical records of 167 patients on ECMO support at a tertiary care university hospital between March 2002 and November 2011...
September 2, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28864223/risk-factors-for-disease-progression-after-postprostatectomy-salvage-radiation-long-term-results-of-a-single-institution-experience
#14
Danielle Rodin, Michael Drumm, Rebecca Clayman, Daniela L Buscariollo, Sigolene Galland-Girodet, Alec Eidelman, Adam S Feldman, Douglas M Dahl, Francis J McGovern, Aria F Olumi, Andrzej Niemierko, William U Shipley, Anthony L Zietman, Jason A Efstathiou
BACKGROUND: Salvage radiotherapy (SRT) has been successfully used for recurrent prostate cancer after radical prostatectomy; however, the optimal timing of SRT remains controversial. Our objective was to identify the risk factors for disease progression after SRT, with a focus on the pre-SRT prostate-specific antigen (PSA) levels in the modern era of PSA testing. PATIENTS AND METHODS: We performed a retrospective review of 551 consecutive patients who had undergone postradical prostatectomy SRT for recurrent prostate cancer from 2000 to 2013...
August 3, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28841633/extracorporeal-circulatory-support-in-acute-coronary-syndromes-a-systematic-review-and-meta-analysis
#15
Rita Pavasini, Chiara Cirillo, Gianluca Campo, Miguel Nobre Menezes, Simone Biscaglia, Elisabetta Tonet, Roberto Ferrari, Brijesh V Patel, Susanna Price
OBJECTIVES: Extracorporeal circulatory support is a life-saving technique, and its use is increasing in acute coronary syndromes. A meta-analysis on pooled event rate of short-term mortality and complications of acute coronary syndrome patients treated with extracorporeal circulatory support was performed. DATA SOURCES: Articles were searched in MEDLINE, Cochrane Library, Google Scholar, and Biomed Central. STUDY SELECTION: Inclusion criteria were observational studies on acute coronary syndrome patients treated with extracorporeal circulatory support...
August 24, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28826417/the-construct-validity-of-general-and-specific-dimensions-of-personality-pathology
#16
T F Williams, M D Scalco, L J Simms
BACKGROUND: Modern personality disorder (PD) theory and research attempt to distinguish transdiagnostic impairments common to all PDs from constructs that explain varied PD expression. Bifactor modeling tests such distinctions; however, the only published PD criteria bifactor analysis focused on only 6 PDs and did not examine the model's construct validity. METHODS: We examined the structure and construct validity of competing PD criteria models using confirmatory and exploratory factor analytic methods in 628 patients who completed structured diagnostic interviews and self-reports of personality traits and impairment...
August 22, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28826306/performance-on-the-test-of-memory-malingering-is-predicted-by-the-number-of-errors-on-its-first-10-items-on-an-inpatient-epilepsy-monitoring-unit
#17
Jonathan M Grabyan, Robert L Collins, W Alexander Alverson, David K Chen
OBJECTIVE: Performance validity testing is an increasingly vital component of neuropsychological evaluation, though administration of stand-alone performance validity tests (PVTs) can be time-consuming. As the Test of Memory Malingering (TOMM) is among the most commonly used and researched PVTs, much work has focused on creating abbreviated versions while preserving diagnostic accuracy. A recent addition to this effort, errors on the first 10 items of Trial 1 (TOMMe10), was analyzed for its utility in predicting TOMM performance...
August 22, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28822756/differences-in-psychosocial-and-behavioral-variables-by-dietary-screening-tool-risk-category-in-older-adults
#18
Geoffrey W Greene, Ingrid Lofgren, Chelsea Paulin, Mary L Greaney, Phillip G Clark
BACKGROUND: The Dietary Screening Tool (DST) has been validated as a dietary screening instrument for older adults defining three categories of potential nutritional risk based on DST score cutoffs. Previous research has found that older adults classified as being "at risk" differed from those categorized as being "not at risk" for a limited number of health-related variables. The relationship between risk categories and a wide variety of variables has not yet been explored. This research will contribute to an increased understanding of clustering of multiple health concerns in this population...
August 17, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28772164/multiple-criteria-decision-analysis-mcda-for-evaluating-new-medicines-in-health-technology-assessment-and-beyond-the-advance-value-framework
#19
Aris Angelis, Panos Kanavos
Escalating drug prices have catalysed the generation of numerous "value frameworks" with the aim of informing payers, clinicians and patients on the assessment and appraisal process of new medicines for the purpose of coverage and treatment selection decisions. Although this is an important step towards a more inclusive Value Based Assessment (VBA) approach, aspects of these frameworks are based on weak methodologies and could potentially result in misleading recommendations or decisions. In this paper, a Multiple Criteria Decision Analysis (MCDA) methodological process, based on Multi Attribute Value Theory (MAVT), is adopted for building a multi-criteria evaluation model...
September 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28752910/antioxidants-for-female-subfertility
#20
REVIEW
Marian G Showell, Rebecca Mackenzie-Proctor, Vanessa Jordan, Roger J Hart
BACKGROUND: A couple may be considered to have fertility problems if they have been trying to conceive for over a year with no success. This may affect up to a quarter of all couples planning a child. It is estimated that for 40% to 50% of couples, subfertility may result from factors affecting women. Antioxidants are thought to reduce the oxidative stress brought on by these conditions. Currently, limited evidence suggests that antioxidants improve fertility, and trials have explored this area with varied results...
July 28, 2017: Cochrane Database of Systematic Reviews
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