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acinetobacter baumannii bacteremia

Rajeev Soman, Neha Gupta, Mitesh Suthar, Jatin Kothari, Alan Almeida, Anjali Shetty, Camilla Rodrigues
BACKGROUND: Central-line-associated blood-stream infection (CLABSI) is a highly consequential nosocomial infection. The most effective management includes the removal of the infected catheter. Retention of the catheter and antibiotic lock therapy (ALT) along with systemic antibiotics may be attempted only if there are unusual extenuating circumstances. CLABSIs due to Gram-negative bacteria (GNB) is more common in our setting and the organisms are often highly resistant. Hence, there is a need to explore the use of novel antimicrobials for catheter lock solutions along with antibiofilm agents...
February 2016: Journal of the Association of Physicians of India
Yi-Tzu Lee, Mei-Chun Chiang, Shu-Chen Kuo, Yung-Chih Wang, I-Hsin Lee, Te-Li Chen, Ya-Sung Yang
The carbapenem breakpoints set by different organizations for Acinetobacter are discordant, but supporting clinical data are lacking. This study aimed to provide the first clinical outcome data to support the carbapenem breakpoints for Acinetobacter baumannii (Ab) group in patients with bacteremia. This study included 117 adults who received carbapenems for treatment of Ab group bacteremia in Taipei Veterans General Hospital over an 8-year period. We analyzed 30-day mortality rates among patient groups acquiring isolates with different carbapenem minimal inhibitory concentrations (MICs)...
2016: PloS One
Guangtao Huang, Supeng Yin, Lijuan Xiang, Yali Gong, Kedai Sun, Xiaoqiang Luo, Cheng Zhang, Zichen Yang, Liuyang Deng, Bei Jiang, Shouguang Jin, Jing Chen, Yizhi Peng
Acinetobacter baumannii infection is a serious threat to burn patients. Bacteremia due to A. baumannii is becoming the most common cause of mortality following burn. However, the epidemiology of A. baumannii causing burn-related bloodstream infections has rarely been reported. We retrospectively collected 81 A. baumannii isolates from the bloodstream of burn patients over a three-year period. Antibiotic susceptibility tests, the prevalence of antibiotic-resistant genes and sequence typing (ST) were conducted to characterize these strains...
November 2016: Burns: Journal of the International Society for Burn Injuries
Seongman Bae, Min-Chul Kim, Su-Jin Park, Hee Sueng Kim, Heungsup Sung, Mi-Na Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Jun Hee Woo, Yang Soo Kim, Yong Pil Chong
Emerging resistance to colistin in clinical Acinetobacter baumannii isolates is of growing concern. Since current treatment options for these strains are extremely limited, we investigated the in vitro activities of various antimicrobial combinations against colistin-resistant A. baumannii. Nine clinical isolates (8 from bacteremia cases and 1 from pneumonia case) of colistin-resistant A. baumannii were collected in Asan Medical Center, Seoul, Korea, between Jan 2010 and Dec 2012. To screen for potential synergistic effects, multiple combinations of two antimicrobials among 12 commercially available agents were tested using the multiple-combination bactericidal test (MCBT)...
September 6, 2016: Antimicrobial Agents and Chemotherapy
Christopher Tam Song, Jolie Hwee, Colin Song, Bien Keem Tan, Si Jack Chong
BACKGROUND: With various changes implemented such as perioperative antibiotics for tangential excision, this retrospective study reviews the infection profile of burn patients at Singapore's only centralized burns unit. Worldwide, the appearance of multidrug-resistant (MDR) strains of Acinetobacter baumannii (A. baumannii) continues to worsen patient outcomes. This study also surveys the role of blood cultures in burns at our unit. METHODS: Four hundred fifty-two burn patients admitted to the unit between 2011 and 2013, and with cultures performed, were included in the study...
2016: Burns and trauma
Ji-Yong Lee, Cheol-In Kang, Jae-Hoon Ko, Woo Joo Lee, Hye-Ri Seok, Ga Eun Park, Sun Young Cho, Young Eun Ha, Doo Ryeon Chung, Nam Yong Lee, Kyong Ran Peck, Jae-Hoon Song
BACKGROUND: With the increasing use of carbapenems, carbapenem-resistant Gram-negative bacteria have become a major concern in healthcare-associated infections. This study was performed to evaluate the clinical and microbiological features of breakthrough Gram-negative bacteremia (GNB) during carbapenem therapy and to assess risk factors for development of breakthrough GNB. METHODS: A case-control study was performed at a tertiary hospital from 2005 to 2014. Cases were defined as individuals whose blood cultures grew Gram-negative bacteria while receiving carbapenems for at least 48 hours before breakthrough GNB...
August 29, 2016: Antimicrobial Agents and Chemotherapy
Fawzia E Al-Otaibi, Elham E Bukhari, Mona Badr, Abdulkarim A Alrabiaa
OBJECTIVES: To evaluate the epidemiology, risk factors, and antibiotic resistance of Gram negative bacteria (GNB) in patients with hematologic or solid organ malignancies.   METHODS: This is a retrospective study of 61 episodes of GNB bacteremia occurring in 56 patients with malignancy admitted to the Oncology Units in King Khalid University Hospital, Riyadh. Kingdom of Saudi Arabia during the period from January 2013 to October 2015. Data were retrieved from the computerized database of the microbiology laboratory and the patient's medical records...
September 2016: Saudi Medical Journal
Sargurunathan Subashchandrabose, Sara Smith, Valerie DeOrnellas, Sebastien Crepin, Monica Kole, Carina Zahdeh, Harry L T Mobley
Acinetobacter baumannii is emerging as a leading global multiple-antibiotic-resistant nosocomial pathogen. The identity of genes essential for pathogenesis in a mammalian host remains largely unknown. Using transposon-directed insertion-site sequencing (TraDIS), we identified A. baumannii genes involved in bacterial survival in a leukopenic mouse model of bloodstream infection. Mice were inoculated with a pooled transposon mutant library derived from 109,000 mutants, and TraDIS was used to map transposon insertion sites in the genomes of bacteria in the inoculum and of bacteria recovered from mouse spleens...
January 2016: MSphere
Hadir A El-Mahallawy, Safaa Shawky Hassan, Mohamed El-Wakil, Manar M Moneer
BACKGROUND AND AIM: In recent years, a few of the antibiotic-resistant bacteria, known as ESKAPE pathogens, have been found responsible for serious infections. We investigated the risk factors, and impact of ESKAPE pathogens on course of blood stream infections (BSIs) in cancer patients in comparison to coagulase negative Staphylococci (CoNS). PATIENTS AND METHODS: The data of patients with ESKAPE positive blood cultures at National Cancer Institute, Cairo University were analyzed...
September 2016: Journal of the Egyptian National Cancer Institute
Saranya Vijayakumar, Sangeetha Rajenderan, Shakti Laishram, Shalini Anandan, Veeraraghavan Balaji, Indranil Biswas
Acinetobacter baumannii is a nosocomial pathogen involved in various infections ranging from minor soft-tissue infections to more severe infections such as ventilator-associated pneumonia and bacteremia. The severity and the type of infections depend on the genetic and phenotypic variations of the strains. In this study, we compared the extent of biofilm formation and motility displayed by 60 multidrug-resistant A. baumannii clinical strains isolated from blood and sputum samples from patients from Southern India...
2016: Frontiers in Public Health
R Parra Millán, M E Jiménez Mejías, V Sánchez Encinales, R Ayerbe Algaba, A Gutiérrez Valencia, M E Pachón Ibáñez, C Díaz, J Pérez Del Palacio, L F López Cortés, J Pachón, Y Smani
Immune response stimulation to prevent infection progression may be an adjuvant to antimicrobial treatment. Lysophosphatidylcholine (LPC) is an immunomodulator involved in immune cell recruitment and activation. In this study, we aimed to evaluate the efficacy of LPC in combination with colistin, tigecycline, or imipenem in experimental murine models of peritoneal sepsis and pneumonia. We used Acinetobacter baumannii strain Ab9, which is susceptible to colistin, tigecycline, and imipenem, and multidrug-resistant strain Ab186, which is susceptible to colistin and resistant to tigecycline and imipenem...
August 2016: Antimicrobial Agents and Chemotherapy
Wayne A Warner, Shan N Kuang, Rina Hernandez, Melissa C Chong, Peter J Ewing, Jen Fleischer, Jia Meng, Sheena Chu, Dawn Terashita, L'Tanya English, Wangxue Chen, H Howard Xu
BACKGROUND: Antibiotic resistant strains of Acinetobacter baumannii have been responsible for an increasing number of nosocomial infections including bacteremia and ventilator-associated pneumonia. In this study, we analyzed 38 isolates of A. baumannii obtained from two hospital outbreaks in Los Angeles County for the molecular epidemiology, antimicrobial susceptibility and resistance determinants. METHODS: Pulsed field gel electrophoresis, tri-locus multiplex PCR and multi-locus sequence typing (Pasteur scheme) were used to examine clonal relationships of the outbreak isolates...
2016: BMC Infectious Diseases
Dong Liu, Zeng-Shan Liu, Pan Hu, Ling Cai, Bao-Quan Fu, Yan-Song Li, Shi-Ying Lu, Nan-Nan Liu, Xiao-Long Ma, Dan Chi, Jiang Chang, Yi-Ming Shui, Zhao-Hui Li, Waqas Ahmad, Yu Zhou, Hong-Lin Ren
Acinetobacter baumannii is a Gram-negative bacillus that causes nosocomial infections, such as bacteremia, pneumonia, and meningitis and urinary tract and wound infections. In the present study, the surface antigen protein 1 (SurA1) gene of A. baumannii strain CCGGD201101 was identified, cloned and expressed, and then its roles in fitness and virulence were investigated. Virulence was observed in the human lung cancer cell lines A549 and HEp-2 at one week after treatment with recombinant SurA1. One isogenic SurA1 knock-out strain, GR0015, which was derived from the A...
April 15, 2016: Veterinary Microbiology
Zhenyang Gu, Yuliang Han, Taojiang Meng, Shasha Zhao, Xiaoli Zhao, Chunji Gao, Wenrong Huang
Acinetobacter (A.) baumannii, an opportunistic nosocomial pathogen that can cause significant morbidity and mortality, has emerged as a worldwide problem. This study aimed to analyze the clinical features and outcomes of patients with A. baumannii bacteremia and determine the factors influencing survival by using 14-day mortality as the primary endpoint. A 6-year retrospective study of 122 cases with monomicrobial A. baumannii bacteremia was conducted in Chinese People's Liberation Army (PLA) General Hospital from January 2008 to April 2014...
March 2016: Medicine (Baltimore)
Richard A Murphy, Luba Nisenbaum, Amy S Labar, Robert L Sheridan, Jean-Baptiste Ronat, Kelly Dilworth, Jade Pena, Erin Kilborn, Carrie Teicher
BACKGROUND: Compare to high-income settings, survival in burn units in low-income settings is lower with invasive infections one leading cause of death. Médecins Sans Frontières is involved in the treatment of large burns in adults and children in Haiti. METHODS: In 2014, we performed a review of 228 patients admitted consecutively with burn injury during a 6-month period to determine patient outcomes and infectious complications. Microbiology was available through a linkage with a Haitian organization...
July 2016: World Journal of Surgery
Evgeni Brotfain, Abraham Borer, Leonid Koyfman, Lisa Saidel-Odes, Amit Frenkel, Shaun E Gruenbaum, Vsevolod Rosenzweig, Alexander Zlotnik, Moti Klein
PURPOSE: Acinetobacter baumannii is a multidrug resistant (MDR), gram-negative bacterium commonly implicated in ventilator-associated pneumonia (VAP) in critically ill patients. Patients in the intensive care unit (ICU) with VAP often subsequently develop A baumannii bacteremia, which may significantly worsen outcomes. MATERIALS AND METHODS: In this study, we retrospectively reviewed the clinical and laboratory records of 129 ICU patients spanning 6 years with MDR A baumannii VAP; 46 (35%) of these patients had concomitant MDR A baumannii bacteremia...
February 21, 2016: Journal of Intensive Care Medicine
Johanna Marcela Vanegas, Luis Felipe Higuita, Carlos Andrés Vargas, Astrid Vanessa Cienfuegos, Érika Andrea Rodríguez, Gustavo Eduardo Roncancio, Judy Natalia Jiménez
INTRODUCTION: Acinetobacter baumannii is an opportunistic bacterium which infects seriously ill patients, particularly those with ventilator-associated pneumonia and bacteremia. The emergence of resistance to carbapenem limits the options for the treatment of infections caused by this bacterium. OBJECTIVE: To describe the clinical and molecular characteristics of infections caused by carbapenem-resistant A. baumannii in Medellín hospitals. MATERIALS AND METHODS: A cross-sectional descriptive study was carried out in five Medellín hospitals over a 2-year period...
December 2015: Biomédica: Revista del Instituto Nacional de Salud
Ninghui Guo, Wencheng Xue, Dahai Tang, Jinya Ding, Bin Zhao
The purpose of this study was to determine the risk factors and outcomes of bloodstream infections caused by multidrug-resistant (MDR) Acinetobacter baumannii complex in a hospital of Northern China. Risk factors associated with MDR A baumannii complex included older age, pneumonia, using drainage catheters, and intensive care unit stay. Multivariate analysis showed that multidrug resistance and mechanical ventilation were identified as independent risk factors for 30-day mortality in patients with A baumannii complex bacteremia...
April 1, 2016: American Journal of Infection Control
Kozue Kishii, Ken Kikuchi, Junko Tomida, Yoshiaki Kawamura, Atsushi Yoshida, Katsuko Okuzumi, Kyoji Moriya
Acinetobacter seifertii, a novel species of Acinetobacter, was first reported in 2015. A. seifertii strains were isolated from human clinical specimens (blood, respiratory tract, and ulcer) and hospital environments. Here, we report the first cases of bacteremia caused by A. seifertii in patients with catheter-related bloodstream infection in Japan. The patients favorably recovered, without any complications, after removal of the peripheral intravenous catheters and administration of antibiotics. The pathogens were initially identified as Acinetobacter baumannii, using phenotypic methods and the MicroScan Walkaway System; however, rpoB gene sequence analysis indicated 99...
May 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Beatriz Larru, Wu Gong, Neika Vendetti, Kaede V Sullivan, Russell Localio, Theoklis E Zaoutis, Jeffrey S Gerber
BACKGROUND: Bloodstream infection is a major cause of morbidity and mortality. Much of our understanding of the epidemiology and resistance patterns of bloodstream infections comes from studies of hospitalized adults. METHODS: We evaluated the epidemiology and antimicrobial resistance of bloodstream infections occurring during an 11-year period in a large, tertiary care children's hospital in the US. All positive blood cultures were identified retrospectively from clinical microbiology laboratory records...
May 2016: Pediatric Infectious Disease Journal
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