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acinetobacter baumannii bacteremia

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https://www.readbyqxmd.com/read/28705768/the-clinical-and-microbiological-characteristics-of-infections-in-burn-patients-from-the-formosa-fun-coast-dust-explosion
#1
Tzu-Chao Lin, Rui-Xin Wu, Chih-Chien Chiu, Ya-Sung Yang, Yi Lee, Jung-Chung Lin, Feng-Yee Chang
BACKGROUND/PURPOSE: Bloodstream infection is a leading cause of mortality among burn patients. This study aimed to evaluate the risk factors, causative pathogens, and the relationship between bloodstream infections and other infections among burn patients from the Formosa Fun Coast Dust Explosion. METHODS: This retrospective study evaluated the demographic and clinical characteristics, infection types, causative pathogen(s), and isolates' antibiotic susceptibilities from patients who were hospitalized between June 27 and September 31, 2015...
June 22, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28701266/community-acquired-bloodstream-infections-caused-by-acinetobacter-baumannii-a%C3%A2-matched-case-control-study
#2
Chung-Ting Chen, Yung-Chih Wang, Shu-Chen Kuo, Fang-Huy Shih, Te-Li Chen, Chorng-Kuang How, Ya-Sung Yang, Yi-Tzu Lee
BACKGROUND: Acinetobacter baumannii is an important nosocomial pathogen worldwide. Its role in community-acquired infection remains controversial and has rarely been reported. METHODS: Patients with monobacterial bloodstream infections caused by genomic species identified A. baumannii, admitted to Taipei Veterans General Hospital between 1999 and 2010, were selected as cases. Controls were defined as patients acquiring infection in a healthcare setting and were matched for age and sex...
June 29, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28686744/should-we-treat-patients-with-only-one-set-of-positive-blood-cultures-for-extensively-drug-resistant-acinetobacter-baumannii-the-same-as-multiple-sets
#3
Aristine Cheng, Yu-Chung Chuang, Hsin-Yun Sun, Chia-Jui Yang, Hou-Tai Chang, Jia-Ling Yang, Wang-Huei Sheng, Yee-Chun Chen, Shan-Chwen Chang
Acinetobacter species are not considered skin commensals and under-treatment is an overriding concern when caring for critically-ill patients who are mostly at risk of extensively drug-resistant Acinetobacter baumannii (XDRAB) infections. Hence even a single blood culture yielding XDRAB will tend to prompt intervention. However, field observations suggest that patients with single-positive blood cultures had milder disease and were more likely to be recruited in interventional studies than those with multiple-positive blood cultures, yet no distinction is made in current clinical or trial recruitment practices...
2017: PloS One
https://www.readbyqxmd.com/read/28669800/sensitivity-and-specificity-of-matrix-associated-laser-desorption-ionization-time-of-flight-mass-spectrometry-maldi-tof-ms-in-discrimination-at-species-level-for-acinetobacter-bacteremia
#4
Meng-San Wu, Sophie Collier, Po-Yu Liu, Yi-Tzu Lee, Shu-Chen Kuo, Ya-Sung Yang, Te-Li Chen, Zi-Yuan Shi, Chin-Fu Lin
We aimed to establish the role of MALDI-TOF MS on species discrimination of phenotypically indistinguishable A. baumannii, A. pittii and A. nosocomialis. Compared to multiplex PCR, the gold standard, MALDI-TOF MS yielded a high sensitivity for A. baumannii (97.9%) and specificity for A. pittii (98.9%) and A. nosocomialis (100%).
June 29, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28664267/transdermally-administered-proline-arginine-rich-host-defense-peptides-show-systemic-efficacy-in-a-lethal-mouse-bacteremia-model
#5
Eszter Ostorhazi, Andrea Horvath, Dora Szabo, Laszlo Otvos
Host defense peptides are preferably administered as topical therapeutic agents. We have investigated whether peptide A3-APO can enter the circulation when applied to the ear skin. Efficacy of peptide monotherapy as transdermal administration option was assessed in a systemic mouse Acinetobacter baumannii model. A3-APO reduced mortality and demonstrated a statistically significant reduction of blood bacterial counts, regardless whether it was administered prior or after bacterial challenge. The peptidic metabolite of A3-APO was efficacious when applied to the ear or tail...
June 29, 2017: Amino Acids
https://www.readbyqxmd.com/read/28650701/prevalence-of-acinetobacter-baumannii-strains-expressing-the-type-6-secretion-system-in-patients-with-bacteremia
#6
Guillermo D Repizo
No abstract text is available yet for this article.
June 26, 2017: Virulence
https://www.readbyqxmd.com/read/28572073/tigecycline-treatment-in-an-infant-with-extensively-drug-resistant-acinetobacter-baumannii-bacteremia
#7
Jiawei Zeng, Lidan Zhang, Min Gao, Jingjing Wu, Haiyan Wu, Jie Chen, Xiao Chen, Wen Tang
The successful use of tigecycline in a 12-month old liver transplant recipient with extensively drug-resistant Acinetobacter baumannii bacteremia is presented. Tigecycline serum concentrations were monitored to help improve antibiotic efficacy and minimize side effects. A literature review identified 11 additional pediatric cases of A. baumannii infection treated with tigecycline since 2011. Tigecycline treatment should be considered in children with extensively drug-resistant bacterial infections.
May 29, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28523249/risk-factors-clinical-presentation-and-outcome-of-acinetobacter-baumannii-bacteremia
#8
Tala Ballouz, Jad Aridi, Claude Afif, Jihad Irani, Chantal Lakis, Rakan Nasreddine, Eid Azar
Infections caused by Acinetobacter baumannii (AB), an increasingly prevalent nosocomial pathogen, have been associated with high morbidity and mortality. We conducted this study to analyze the clinical features, outcomes, and factors influencing the survival of patients with AB bacteremia. We retrospectively examined the medical records of all patients developing AB bacteremia during their hospital stay at a tertiary care hospital in Beirut between 2010 and 2015. Ninety episodes of AB bacteremia were documented in eighty-five patients...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28453834/overproduction-of-outer-membrane-protein-a-by-acinetobacter-baumannii-as-a-risk-factor-for-nosocomial-pneumonia-bacteremia-and-mortality-rate-increase
#9
MULTICENTER STUDY
Viviana Sánchez-Encinales, Rocío Álvarez-Marín, María Eugenia Pachón-Ibáñez, Felipe Fernández-Cuenca, Alvaro Pascual, José Garnacho-Montero, Luis Martínez-Martínez, Jordi Vila, María Mar Tomás, José Miguel Cisneros, Germán Bou, Jesús Rodríguez-Baño, Jerónimo Pachón, Younes Smani
Background.: Outer membrane protein A (OmpA) is a porin involved in Acinetobacter baumannii pathogenesis. However, OmpA clinical implication in hospital-acquired infections remains unknown. We aimed to determine whether OmpA overproduction was a risk factor associated with pneumonia, bacteremia, and mortality. Methods.: We analyzed demographic, microbiological, and clinical data from 100 patients included in a unicenter cohort and 246 included in a unicenter cohort and a multicenter cohort...
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28448786/microbiological-features-and-clinical-impact-of-the-type-vi-secretion-system-t6ss-in-acinetobacter-baumannii-isolates-causing-bacteremia
#10
Jungok Kim, Ji-Young Lee, Haejeong Lee, Ji Young Choi, Dae Hun Kim, Yu Mi Wi, Kyong Ran Peck, Kwan Soo Ko
We investigated the genetic background and microbiological features of T6SS-positive Acinetobacter baumannii isolates and clinical impact of the T6SS in patients with A. baumannii bacteremia. One hundred and 62 A. baumannii isolates from patients with bacteremia in 2 tertiary-care hospitals in Korea were included in this study. Approximately one-third (51/162, 31.5%) of the A. baumannii clinical isolates possessed the hcp gene, and the hcp-positive isolates were found in several genotypes in multilocus sequence typing...
April 27, 2017: Virulence
https://www.readbyqxmd.com/read/28446911/the-immune-response-against-acinetobacter-baumannii-an-emerging-pathogen-in-nosocomial-infections
#11
REVIEW
María Guadalupe García-Patiño, Rodolfo García-Contreras, Paula Licona-Limón
Acinetobacter baumannii is the etiologic agent of a wide range of nosocomial infections, including pneumonia, bacteremia, and skin infections. Over the last 45 years, an alarming increase in the antibiotic resistance of this opportunistic microorganism has been reported, a situation that hinders effective treatments. In order to develop effective therapies against A. baumannii it is crucial to understand the basis of host-bacterium interactions, especially those concerning the immune response of the host...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28375520/global-gene-expression-profile-of-acinetobacter-baumannii-during-bacteremia
#12
Gerald L Murray, Kirill Tsyganov, Xenia P Kostoulias, Dieter M Bulach, David Powell, Darren J Creek, John D Boyce, Ian T Paulsen, Anton Y Peleg
Background.: Acinetobacter baumannii is a pathogen of major importance in intensive care units worldwide, with the potential to cause problematic outbreaks and acquire high-level resistance to antibiotics. There is an urgent need to understand the mechanisms of A. baumannii pathogenesis for the future development of novel targeted therapies. In this study we performed an in vivo transcriptomic analysis of A. baumannii isolated from a mammalian host with bacteremia. Methods...
February 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28265870/correlation-between-antibiotic-consumption-and-resistance-of-bloodstream-bacteria-in-a-university-hospital-in-north-eastern-italy-2008-2014
#13
Marta Mascarello, Omar Simonetti, Anna Knezevich, Ludovica Ilaria Carniel, Jacopo Monticelli, Marina Busetti, Paolo Schincariol, Lucio Torelli, Roberto Luzzati
PURPOSE: The spread of multidrug-resistant bacteria is a worrisome problem worldwide. This study investigated the correlation between antibiotic consumption and antimicrobial resistance trends of the most important bacteria causing bacteremia at the University hospital of Trieste, Italy, from 2008 to 2014. METHODS: Antibiotic consumption (Defined Daily Dose-DDD-per 100 patient/days) and antibiotic resistance (percentage of antibiotic intermediate o resistant isolates) were analyzed independently with linear correlation by year...
March 6, 2017: Infection
https://www.readbyqxmd.com/read/28205160/non-fermentative-gram-negative-rods-bacteremia-in-children-with-cancer-a-14-year-single-center-experience
#14
D Averbuch, C Avaky, M Harit, P Stepensky, I Fried, T Ben-Ami, V Temper, Y Peled, H Troen, R Masarwa, W Abu Ahmad, M Weintraub, S Revel-Vilk, D Engelhard
PURPOSE: Data on non-fermentative Gram-negative rods (NFGNR) bacteremia in children with malignancies are limited. The aim of this study was to present clinical picture, antimicrobial susceptibility pattern, risk factors for resistance and outcome in NFGNR bacteremia in children with cancer. METHODS: All episodes of NFGNR bacteremia occurring during 2001-2014 in children with cancer in a tertiary-care hospital were retrospectively analyzed. Pseudomonas and Acinetobacter spp...
June 2017: Infection
https://www.readbyqxmd.com/read/28185779/corrigendum-to-comparison-of-the-clinical-efficacy-between-tigecycline-plus-extended-infusion-imipenem-and-sulbactam-plus-imipenem-against-ventilator-associated-pneumonia-with-pneumonic-extensively-drug-resistant-acinetobacter-baumannii-bacteremia-and-correlation
#15
https://www.readbyqxmd.com/read/28119484/overproduction-of-outer-membrane-protein-a-ompa-by-acinetobacter-baumannii-is-a-risk-factor-for-nosocomial-pneumonia-bacteremia-and-mortality-increase
#16
Viviana Sánchez-Encinales, Rocío Álvarez-Marín, María Eugenia Pachón-Ibáñez, Felipe Fernández-Cuenca, Alvaro Pascual, José Garnacho-Montero, Luis Martínez-Martínez, Jordi Vila, María Mar Tomás, José Miguel Cisneros, Germán Bou, Jesús Rodríguez-Baño, Jerónimo Pachón, Younes Smani
BACKGROUND: OmpA is a porin involved in Acinetobacter baumannii pathogenesis. However, OmpA clinical implication in hospital-acquired infections remains unknown. We aimed to determine whether OmpA overproduction was a risk factor associated with pneumonia, bacteremia, and mortalilty. METHODS: Demographic, microbiological and clinical data from 100 and 246 patients included, respectively, in a unicenter cohort (UC) and a multicenter cohort (MC) were analyzed. Representative isolates were classified in two groups: i-16 UC and 20 MC isolates from colonized patients (CP) by A...
January 24, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27992528/colistin-dosage-without-loading-dose-is-efficacious-when-treating-carbapenem-resistant-acinetobacter-baumannii-ventilator-associated-pneumonia-caused-by-strains-with-high-susceptibility-to-colistin
#17
Rocío Álvarez-Marín, Rafael López-Rojas, Juan Antonio Márquez, María José Gómez, José Molina, José Miguel Cisneros, Carlos Ortiz-Leyba, Javier Aznar, José Garnacho-Montero, Jerónimo Pachón
OBJECTIVES: This study aims to analyze the mortality and the length of ICU stay (LOS) of A. baumannii VAP compared to respiratory colonization in patients with mechanical ventilation (MV). METHODS: A prospective cohort study was performed in an ICU of adult patients (February 2010-June 2011). One hundred patients on MV with A. baumannii in lower respiratory airways were recruited, and classified as VAP or airways colonization according to CPIS criteria, with a punctuation ≥6...
2016: PloS One
https://www.readbyqxmd.com/read/27730778/antibiotic-lock-therapy-in-the-era-of-gram-negative-resistance
#18
Rajeev Soman, Neha Gupta, Mitesh Suthar, Jatin Kothari, Alan Almeida, Anjali Shetty, Camilla Rodrigues
BACKGROUND: Central-line-associated blood-stream infection (CLABSI) is a highly consequential nosocomial infection. The most effective management includes the removal of the infected catheter. Retention of the catheter and antibiotic lock therapy (ALT) along with systemic antibiotics may be attempted only if there are unusual extenuating circumstances. CLABSIs due to Gram-negative bacteria (GNB) is more common in our setting and the organisms are often highly resistant. Hence, there is a need to explore the use of novel antimicrobials for catheter lock solutions along with antibiofilm agents...
February 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27644087/carbapenem-breakpoints-for-acinetobacter-baumannii-group-supporting-clinical-outcome-data-from-patients-with-bacteremia
#19
Yi-Tzu Lee, Mei-Chun Chiang, Shu-Chen Kuo, Yung-Chih Wang, I-Hsin Lee, Te-Li Chen, Ya-Sung Yang
The carbapenem breakpoints set by different organizations for Acinetobacter are discordant, but supporting clinical data are lacking. This study aimed to provide the first clinical outcome data to support the carbapenem breakpoints for Acinetobacter baumannii (Ab) group in patients with bacteremia. This study included 117 adults who received carbapenems for treatment of Ab group bacteremia in Taipei Veterans General Hospital over an 8-year period. We analyzed 30-day mortality rates among patient groups acquiring isolates with different carbapenem minimal inhibitory concentrations (MICs)...
2016: PloS One
https://www.readbyqxmd.com/read/27614427/epidemiological-characterization-of-acinetobacter-baumannii-bloodstream-isolates-from-a-chinese-burn-institute-a-three-year-study
#20
Guangtao Huang, Supeng Yin, Lijuan Xiang, Yali Gong, Kedai Sun, Xiaoqiang Luo, Cheng Zhang, Zichen Yang, Liuyang Deng, Bei Jiang, Shouguang Jin, Jing Chen, Yizhi Peng
Acinetobacter baumannii infection is a serious threat to burn patients. Bacteremia due to A. baumannii is becoming the most common cause of mortality following burn. However, the epidemiology of A. baumannii causing burn-related bloodstream infections has rarely been reported. We retrospectively collected 81 A. baumannii isolates from the bloodstream of burn patients over a three-year period. Antibiotic susceptibility tests, the prevalence of antibiotic-resistant genes and sequence typing (ST) were conducted to characterize these strains...
November 2016: Burns: Journal of the International Society for Burn Injuries
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