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acinetobacter baumannii bacteremia

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https://www.readbyqxmd.com/read/29593918/a-case-of-polymicrobial-bacteremia-in-a-patient-undergoing-chemotherapy
#1
Kyoko Arahata, Ryo Yamaguchi, Takeshi Terashima
We report an aggressive case of polymicrobial bacteremia in a patient with renal pelvis carcinoma. A 76-year-old man developed watery diarrhea after undergoing chemotherapy. He became unconscious and went into shock. Laboratory data showed severe neutropenia, renal failure, and lactic acidosis. Chest radiography showed multiple opacities. He died despite aggressive fluid resuscitation, catecholamine administration, antibiotic treatment, and mechanical ventilation. Blood culture isolates included Escherichia coli , Klebsiella pneumoniae , Streptococcus pneumoniae , Acinetobacter baumannii , and Moraxella catarrhalis ...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29579836/early-bacterial-pneumonia-after-hepatic-transplantation-epidemiologic-profile
#2
J Prieto Amorin, M Lopez, K Rando, J Castelli, J Medina Presentado
BACKGROUND: Postoperative pulmonary complications are major cause of morbidity and mortality in patients receiving liver transplantation (LT), particularly bacterial pneumonia occurring within the first 100 days after transplantation. Our aim in this study was to determine the incidence, microorganisms involved, associated factors, and morbidity of bacterial pneumonia presenting in the first 100 days posttransplant. METHODS: We performed a cohort study in which patients receiving liver transplantation were included prospectively in our national database (Database of Infections in Transplantation of Solid Organs)...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29555630/comparison-of-septic-shock-due-to-mdr-acinetobacter-baumannii-or-klebsiella-pneumoniae-carbapenemase-producing-k-pneumoniae-in-icu-patients
#3
Alessandro Russo, Simone Giuliano, Giancarlo Ceccarelli, Francesco Alessandri, Alessandra Giordano, Grazia Brunetti, Mario Venditti
Objectives: a significant cause of mortality in intensive care unit (ICU) is represented by multidrug-resistant (MDR) gram-negative bacteria, such as MDR Acinetobacter baumannii (MDR-AB) and Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp). Aim of the present study was the comparison of clinical features, therapy and outcome of patients who developed septic shock due to either MDR-AB or KPC-Kp. Methods: were retrospectively analyzed patients admitted to the intensive care unit (ICU) of a teaching hospital, from November 2010 to December 2015, who developed septic shock due to MDR-AB or KPC-Kp infection...
March 19, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29541448/multidrug-resistant-gram-negative-bacterial-infections-in-a-teaching-hospital-in-ghana
#4
Nicholas Agyepong, Usha Govinden, Alex Owusu-Ofori, Sabiha Yusuf Essack
Background: Multidrug-resistant Gram-negative bacteria have emerged as major clinical and therapeutic dilemma in hospitals in Ghana.To describe the prevalence and profile of infections attributable to multidrug-resistant Gram-negative bacteria among patients at the Komfo Anokye Teaching Hospital in the Ashanti region of Ghana. Methods: Bacterial cultures were randomly selected from the microbiology laboratory from February to August, 2015. Bacterial identification and minimum inhibitory concentrations were conducted using standard microbiological techniques and the Vitek-2 automated system...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29487729/prevalence-of-acinetobacter-baumannii-bacteremia-in-intensive-care-units-of-ibn-rochd-university-hospital-casablanca
#5
Assiya El Kettani, Fakhreddine Maaloum, Idrissa Diawara, Khalid Katfy, Nadia Harrar, Khalid Zerouali, Houria Belabbes, Naima Elmdaghri
Background and Objectives: Acinetobacter baumannii bacteremia are grave because of the multi-resistance of the organism to antibiotics. This study aimed to determine the prevalence of A. baumannii isolated from blood cultures and to describe their antibiotic resistance patterns. Materials and Methods: A retrospective longitudinal study was conducted on blood cultures between 2010 and 2014 from all Ibn Rochd University Hospital intensive care units; it was based on the exploitation of microbiology laboratory database (duplicates were excluded)...
December 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29471109/extensively-drug-resistant-acinetobacter-baumannii-bacteremias-in-a-multidisciplinary-intensive-care-unit-during-a-6-year-period-risk-factors-for-fulminant-sepsis
#6
M Katsiari, A Mavroidi, E D Platsouka, C Nikolaou
OBJECTIVES: The aim of the present study was to determine potential host-, pathogen-, infection- and treatment-related risk factors that might predict a fulminant, fatal course of bacteremia caused extensively drug-resistant A. baumannii (XDR Aba). METHODS: Eighty-seven patients with monomicrobial growth of XDR Aba in blood cultures within a 6-year period were studied. Patients were divided into three groups, according to ICU outcome. Group A (n=40) consisted of patients who survived, Group B (n=10) included patients with fulminant sepsis that died early (<48h), whereas Group C (n=37) included patients that died later (> 48h) after the onset of bacteremia...
February 19, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29410094/antibiotic-treatment-of-infections-caused-by-carbapenem-resistant-gram-negative-bacilli-an-international-escmid-cross-sectional-survey-among-infectious-diseases-specialists-practicing-in-large-hospitals
#7
L Papst, B Beović, C Pulcini, E Durante-Mangoni, J Rodríguez-Baño, K S Kaye, G L Daikos, L Raka, M Paul
OBJECTIVES: To explore contemporary antibiotic management of infections caused by carbapenem-resistant Gram-negative bacteria in hospitals. METHODS: Cross-sectional, internet-based questionnaire survey. We contacted representatives of all hospitals with more than 800 acute-care hospital beds in France, Greece, Israel, Italy, Kosovo, Slovenia, Spain and selected hospitals in the USA. We asked respondents to describe the most common actual practice at their hospital regarding management of carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa through close-ended questions...
February 1, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29363656/subsequent-multidrug-resistant-bacteremia-is-a-risk-factor-for-short-term-mortality-of-patients-with-ventilator-associated-pneumonia-caused-by-acinetobacter-baumannii-in-intensive-care-unit-a-multicenter-experience
#8
Mo-Han Ju, Yu-Long Yao, Chun-Ling Du, Shu Chen, Yuan-Lin Song
No abstract text is available yet for this article.
February 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29353378/secular-trends-in-the-appropriateness-of-empirical-antibiotic-treatment-in-patients-with-bacteremia-a-comparison-between-three-prospective-cohorts
#9
Vered Daitch, Yulia Akayzen, Yasmin Abu-Ghanem, Noa Eliakim-Raz, Mical Paul, Leonard Leibovici, Dafna Yahav
The objective of this study was to explore whether the percentage of inappropriate empirical antibiotic treatment in patients with bacteremia changed over time and to understand the factors that brought on the change. Three prospective cohorts of patients with bacteremia in three different periods (January 1st, 1988 to December 31st, 1989; May 1st, 2004 to November 30, 2004; May 1st, 2010 to April 30, 2011) were compared. Analysis was performed on a total of 811 patients. In 2010-2011, 55.9% (76/136) of patients with bacteremia received inappropriate empirical treatment, compared with 34...
March 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29352265/type-i-ifn-operates-pyroptosis-and-necroptosis-during-multidrug-resistant-a-baumannii-infection
#10
Yang Li, Xiaomin Guo, Chunmiao Hu, Yan Du, Chuansheng Guo, Di Wang, Weiheng Zhao, Gonghua Huang, Chunliang Li, Qiumin Lu, Ren Lai, Tao Xu, Xiaopeng Qi
Multidrug-resistant Acinetobacter baumannii, a common pathogen responsible for nosocomial infections, is the main cause for outbreaks of infectious diseases, such as pneumonia, meningitis, and bacteremia, especially among critically ill patients. Epidemic A. baumannii is a growing public health concern as it is resistant to all existing antimicrobial agents, thereby necessitating the development of new therapeutic approaches to mount an effective immune response against this bacterial pathogen. In this study, we identified a critical role for type I interferon (IFN) in epigenetic regulation during A...
January 19, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29298323/implementation-of-global-antimicrobial-resistance-surveillance-system-glass-in-patients-with-bacteremia
#11
Rujipas Sirijatuphat, Kantarida Sripanidkulchai, Adhiratha Boonyasiri, Pinyo Rattanaumpawan, Orawan Supapueng, Pattarachai Kiratisin, Visanu Thamlikitkul
The global antimicrobial resistance surveillance system (GLASS) was launched by the World Health Organization (WHO) in 2015. GLASS is a surveillance system for clinical specimens that are sent to microbiology laboratory for clinical purposes. The unique feature of GLASS is that clinical data is combined with microbiological data, and deduplication of the microbiological results is performed. The objective of the study was to determine feasibility and benefit of GLASS for surveillance of blood culture specimens...
2018: PloS One
https://www.readbyqxmd.com/read/29288723/intravenous-colistin-combination-antimicrobial-treatment-vs-monotherapy-a-systematic-review-and-meta-analysis
#12
REVIEW
Konstantinos Z Vardakas, Andreas D Mavroudis, Maria Georgiou, Matthew E Falagas
BACKGROUND: To evaluate whether intravenous colistin in combination with other antibiotics (IVCC) is associated with lower mortality compared with intravenous colistin monotherapy (IVCM), and to identify factors influencing study outcomes. METHODS: PubMed and Scopus were searched up to November 2016. Studies were included if they evaluated adult patients with multi-drug-resistant (MDR) or extensively-drug-resistant Gram-negative infections, and reported comparative mortality data (adjusted and unadjusted) for patients receiving IVCC vs...
April 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29248504/rapid-emergence-of-colistin-resistance-and-its-impact-on-fatality-among-healthcare-associated-infections
#13
M Aydın, Ö Ergönül, A Azap, H Bilgin, G Aydın, S A Çavuş, Y Z Demiroğlu, H E Alışkan, O Memikoğlu, Ş Menekşe, Ş Kaya, N A Demir, I Karaoğlan, S Başaran, Ç Hatipoğlu, Ş Erdinç, E Yılmaz, A Tümtürk, Y Tezer, H Demirkaya, Ş E Çakar, Ş Keske, S Tekin, C Yardımcı, Ç Karakoç, P Ergen, Ö Azap, L Mülazımoğlu, O Ural, F Can, H Akalın
This article describes the emergence of resistance and predictors of fatality for 1556 cases of healthcare-associated Gram-negative bloodstream infection in 2014 and 2015. The colistin resistance rate in Klebsiella pneumoniae was 16.1%, compared with 6% in 2013. In total, 660 (42.4%) cases were fatal. The highest fatality rate was among patients with Acinetobacter baumannii bacteraemia (58%), followed by Pseudomonas aeruginosa (45%), Klebsiella pneumoniae (41%), Enterobacter cloacae (32%) and Escherichia coli (28%)...
March 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29122697/early-administration-of-appropriate-antimicrobial-agents-to-improve-the-outcome-of-carbapenem-resistant-acinetobacter-baumannii-complex-bacteraemic-pneumonia
#14
Seong Yeon Park, Eun Jung Lee, Tark Kim, Shi Nae Yu, Ki-Ho Park, Mi Suk Lee, Se Yoon Park, Min Hyok Jeon, Tae Hyong Kim, Eun Ju Choo
Carbapenem-resistant Acinetobacter baumannii complex (CRABC) is an emerging pathogen that causes bloodstream infections and nosocomial pneumonia. This study aimed to describe severe infection associated with CRABC bacteraemic pneumonia and to investigate risk factors for 28-day mortality. All patients aged ≥18 years with CRABC bacteraemic pneumonia were enrolled retrospectively at five teaching hospitals in South Korea. Empirical antimicrobial therapy was defined as appropriate if administration of at least one antimicrobial agent, to which the causative pathogen was susceptible, for >48 h, within 5 days of the onset of bacteraemia...
March 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28958447/an-outbreak-of-bloodstream-infection-due-to-extensively-resistant-acinetobacter-baumannii-among-neonates
#15
Aysegul Ulu-Kilic, Aycan Gundogdu, Fatma Cevahir, Huseyin Kilic, Tamer Gunes, Emine Alp
BACKGROUND: Extensively resistant Acinetobacter baumannii has emerged and spread worldwide as a significant cause of health care-associated infections and outbreaks. It also causes life-threatening infections among neonates, including bacteremia. The aim of this study was to investigate an outbreak of A baumannii bacteremia (ABB) among neonates. MATERIALS AND METHODS: A retrospective, case-control study was conducted from July 2014 to July 2015 in a neonatal intensive care unit (NICU)...
September 25, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28904355/highly-potent-antimicrobial-modified-peptides-derived-from-the-acinetobacter-baumannii-phage-endolysin-lysab2
#16
Shih-Yi Peng, Ren-In You, Meng-Jiun Lai, Nien-Tsung Lin, Li-Kuang Chen, Kai-Chih Chang
The increase in the prevalence of multidrug-resistant Acinetobacter baumannii (MDRAB) strains is a serious public health concern. Antimicrobial peptides (AMPs) are a possible solution to this problem. In this study, we examined whether AMPs could be derived from phage endolysins. We synthesized four AMPs based on an amphipathic helical region in the C-terminus of endolysin LysAB2 encoded by the A. baumannii phage ΦAB2. These peptides showed potent antibacterial activity against A. baumannii (minimum inhibitory concentration, 4-64 μM), including some MDR and colistin-resistant A...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28894700/targeting-the-type-ii-secretion-system-development-optimization-and-validation-of-a-high-throughput-screen-for-the-identification-of-small-molecule-inhibitors
#17
Ursula Waack, Tanya L Johnson, Khalil Chedid, Chuanwu Xi, Lyle A Simmons, Harry L T Mobley, Maria Sandkvist
Nosocomial pathogens that develop multidrug resistance present an increasing problem for healthcare facilities. Due to its rapid rise in antibiotic resistance, Acinetobacter baumannii is one of the most concerning gram-negative species. A. baumannii typically infects immune compromised individuals resulting in a variety of outcomes, including pneumonia and bacteremia. Using a murine model for bacteremia, we have previously shown that the type II secretion system (T2SS) contributes to in vivo fitness of A. baumannii...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28879405/infection-control-interventions-affected-by-resource-shortages-impact-on-the-incidence-of-bacteremias-caused-by-carbapenem-resistant-pathogens
#18
E Kousouli, O Zarkotou, L Politi, K Polimeri, G Vrioni, K Themeli-Digalaki, A Tsakris, S Pournaras
We evaluated an infection control (IC) program influenced by personnel and material resource shortages on the incidence of bloodstream infections (BSI) due to carbapenem-resistant Klebsiella pneumoniae (CRKP), Acinetobacter baumannii (CRAB), and Pseudomonas aeruginosa (CRPA) in an endemic region. Between January 2010 and December 2015, all BSI episodes caused by CRKP, CRAB, and CRPA were recorded. An IC bundle was implemented in January 2012. We evaluated the effect of the interventions on BSI rates between the pre-intervention (2010-2011) and intervention (2012-2013) periods, using an interrupted time-series model...
January 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28877134/the-use-of-intravenous-and-inhaled-colistin-therapy-during-a-burn-center-outbreak-of-multidrug-resistant-acinetobacter-baumannii
#19
Tomas J Saun, Alan D Rogers, Jerome A Leis, Robert Cartotto
The authors report on the use of combination intravenous and inhaled colistin therapy in 2 patients with major burns admitted to an American Burn Association-verified burn center during a multidrug-resistant (MDR) Acinetobacter baumannii outbreak. Both patients had documented, culture-proven MDR Acinetobacter ventilator-associated pneumonia and bacteremia leading to sepsis. Both patients were successfully extubated and subsequently discharged from hospital. In this article, the authors provide the timeline of events and treatments that were used in these 2 cases...
August 31, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28868304/treatment-of-sepsis-what-is-the-antibiotic-choice-in-bacteremia-due-to-carbapenem-resistant-enterobacteriaceae
#20
REVIEW
Fatema Alhashem, Nicolette Leonie Tiren-Verbeet, Emine Alp, Mehmet Doganay
Sepsis is one of the major challenges of today. Although gram-positive bacteria related infections are more prevalent in hospital setting, the highest mortality rate is associated with gram-negative microorganisms especially Enterobacteriaceae . Enterobacteriaceae , including Escherichia coli, Klebsiella spp., Proteus spp., Enterobacter spp. and Serratia spp. Resistance to β-lactams in Enterobacteriaceae is primarily attributed to the production of B-lactamase enzymes with subsequent antibiotic hydrolysis and to a lesser extent by alteration of efflux pump or porins expression...
August 16, 2017: World Journal of Clinical Cases
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