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acinetobacter baumannii bloodstream infections

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https://www.readbyqxmd.com/read/29122697/early-administration-of-appropriate-antimicrobial-agent-to-improve-the-outcome-of-carbapenem-resistant-acinetobacter-baumannii-complex-bacteremic-pneumonia
#1
Seong Yeon Park, Eun Jung Lee, Tark Kim, Shi Nae Yu, Ki-Ho Park, Mi Suk Lee, Se Yoon Park, Min Hyok Jeon, Tae Hyong Kim, Eun Ju Choo
BACKGROUND: Carbapenem resistant Acinetobacter baumannii complex (CRABC) is an emerging pathogen that causes bloodstream infections and nosocomial pneumonia. This study aimed to describe the severe infection associated with CRABC bacteremic pneumonia and to investigate risk factors for 28-day mortality. METHODS: All patients ≥18 years of age with a CRABC bacteremic pneumonia were enrolled retrospectively at five teaching hospitals in South Korea. Empirical antimicrobial therapy was defined as appropriate if administration of at least one antimicrobial agent, to which the causative pathogen was susceptible, more than 48 hours, within 5 days of the onset of bacteremia...
November 6, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29069421/comparative-efficacy-and-safety-of-treatment-options-for-mdr-and-xdr-acinetobacter-baumannii-infections-a-systematic-review-and-network-meta-analysis
#2
Kirati Kengkla, Khachen Kongpakwattana, Surasak Saokaew, Anucha Apisarnthanarak, Nathorn Chaiyakunapruk
Objectives: To comprehensively compare and rank the efficacy and safety of available treatment options for patients with MDR and XDR Acinetobacter baumannii (AB) infection. Methods: We searched PubMed, Embase and the Cochrane register of trials systematically for studies that examined treatment options for patients with MDR- and XDR-AB infections until April 2016. Network meta-analysis (NMA) was performed to estimate the risk ratio (RR) and 95% CI from both direct and indirect evidence...
October 24, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29051092/a-study-on-the-targeted-surveillance-of-nosocomial-infection-in-intensive-care-units-of-177-hospitals-in-jiangsu-province-of-china
#3
Yang Li, Xiao-Li Cao, Hai Ge, Yi-Hong Jiang, Hong Zhou, Wei Zheng
BACKGROUND: Nosocomial infections (NIs) impact care and costs in hospitals across the globe. There are minimal data on targeted surveillance of NI in intensive care units (ICUs), and data specific to the risk factors for NI are especially limited. METHODS: One hundred seventy-seven secondary and tertiary hospitals performed NI targeted surveillance in their ICUs. The data were collected and summarized by Minke software, then fed back once per quarter. RESULTS: The incidence of NI appeared to decrease, and the incidence of NI per 1000 patient-days and adjusted incidence were 25...
October 16, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28958447/an-outbreak-of-bloodstream-infection-due-to-extensively-resistant-acinetobacter-baumannii-among-neonates
#4
Aysegul Ulu-Kilic, Aycan Gundogdu, Fatma Cevahir, Huseyin Kilic, Tamer Gunes, Emine Alp
BACKGROUND: Extensively resistant Acinetobacter baumannii has emerged and spread worldwide as a significant cause of health care-associated infections and outbreaks. It also causes life-threatening infections among neonates, including bacteremia. The aim of this study was to investigate an outbreak of A baumannii bacteremia (ABB) among neonates. MATERIALS AND METHODS: A retrospective, case-control study was conducted from July 2014 to July 2015 in a neonatal intensive care unit (NICU)...
September 25, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28940128/multi-locus-sequence-typing-mlst-of-non-fermentative-gram-negative-bacilli-isolated-from-bloodstream-infections-in-southern-poland
#5
Agnieszka Chmielarczyk, Monika Pobiega, Dorota Romaniszyn, Jadwiga Wójkowska-Mach
Non-fermentative Gram-negative bacilli are now one of the most important causes of severe infections in Polish hospitals. Acinetobacter species are serious concern because of the high prevalence of multi-drug resistance among strains. Resistance profiles for 53 Gram-negative non-fermentative blood isolates were done. MLST was carried out using 44 strains representing the most commonly isolated species: A. baumannii, P. aeruginosa, and S. maltophilia. MLST revealed that all 22 A. baumannii belonged to sequence type (ST) 2...
September 22, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28916373/methods-for-computational-disease-surveillance-in-infection-prevention-and-control-statistical-process-control-versus-twitter-s-anomaly-and-breakout-detection-algorithms
#6
Timothy L Wiemken, Stephen P Furmanek, William A Mattingly, Marc-Oliver Wright, Annuradha K Persaud, Brian E Guinn, Ruth M Carrico, Forest W Arnold, Julio A Ramirez
BACKGROUND: Although not all health care-associated infections (HAIs) are preventable, reducing HAIs through targeted intervention is key to a successful infection prevention program. To identify areas in need of targeted intervention, robust statistical methods must be used when analyzing surveillance data. The objective of this study was to compare and contrast statistical process control (SPC) charts with Twitter's anomaly and breakout detection algorithms. METHODS: SPC and anomaly/breakout detection (ABD) charts were created for vancomycin-resistant Enterococcus, Acinetobacter baumannii, catheter-associated urinary tract infection, and central line-associated bloodstream infection data...
September 12, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28879405/infection-control-interventions-affected-by-resource-shortages-impact-on-the-incidence-of-bacteremias-caused-by-carbapenem-resistant-pathogens
#7
E Kousouli, O Zarkotou, L Politi, K Polimeri, G Vrioni, K Themeli-Digalaki, A Tsakris, S Pournaras
We evaluated an infection control (IC) program influenced by personnel and material resource shortages on the incidence of bloodstream infections (BSI) due to carbapenem-resistant Klebsiella pneumoniae (CRKP), Acinetobacter baumannii (CRAB), and Pseudomonas aeruginosa (CRPA) in an endemic region. Between January 2010 and December 2015, all BSI episodes caused by CRKP, CRAB, and CRPA were recorded. An IC bundle was implemented in January 2012. We evaluated the effect of the interventions on BSI rates between the pre-intervention (2010-2011) and intervention (2012-2013) periods, using an interrupted time-series model...
September 6, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28758623/risk-factors-and-predictors-of-carbapenem-resistant-pseudomonas-aeruginosa-and-acinetobacter-baumannii-mortality-in-critically-ill-bacteraemic-patients-over-a-6-year-period-2010-15-antibiotics-do-matter
#8
Matthaios Papadimitriou-Olivgeris, Fotini Fligou, Anastasia Spiliopoulou, Kyriaki Koutsileou, Fevronia Kolonitsiou, Aikaterini Spyropoulou, Anastasia Zotou, Markos Marangos, Evangelos D Anastassiou, Myrto Christofidou, Iris Spiliopoulou
PURPOSE: Acinetobacter baumannii and Pseudomonas aeruginosa provoke serious infections, especially in intensive care unit (ICU) patients. METHODOLOGY: The risk factors and predictors of mortality for P. aeruginosa (n=84; 46 carbapenem-resistant) and A. baumannii (n=129; all carbapenem-resistant) bloodstream infections (BSIs) in an ICU were evaluated. Antibiotic susceptibility testing was performed using the agar disk diffusion method according to EUCAST guidelines...
July 31, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28705768/the-clinical-and-microbiological-characteristics-of-infections-in-burn-patients-from-the-formosa-fun-coast-dust-explosion
#9
Tzu-Chao Lin, Rui-Xin Wu, Chih-Chien Chiu, Ya-Sung Yang, Yi Lee, Jung-Chung Lin, Feng-Yee Chang
BACKGROUND/PURPOSE: Bloodstream infection is a leading cause of mortality among burn patients. This study aimed to evaluate the risk factors, causative pathogens, and the relationship between bloodstream infections and other infections among burn patients from the Formosa Fun Coast Dust Explosion. METHODS: This retrospective study evaluated the demographic and clinical characteristics, infection types, causative pathogen(s), and isolates' antibiotic susceptibilities from patients who were hospitalized between June 27 and September 31, 2015...
June 22, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28701266/community-acquired-bloodstream-infections-caused-by-acinetobacter-baumannii-a%C3%A2-matched-case-control-study
#10
Chung-Ting Chen, Yung-Chih Wang, Shu-Chen Kuo, Fang-Huy Shih, Te-Li Chen, Chorng-Kuang How, Ya-Sung Yang, Yi-Tzu Lee
BACKGROUND: Acinetobacter baumannii is an important nosocomial pathogen worldwide. Its role in community-acquired infection remains controversial and has rarely been reported. METHODS: Patients with monobacterial bloodstream infections caused by genomic species identified A. baumannii, admitted to Taipei Veterans General Hospital between 1999 and 2010, were selected as cases. Controls were defined as patients acquiring infection in a healthcare setting and were matched for age and sex...
June 29, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28642142/epidemiology-and-outcomes-of-bloodstream-infections-in-177-severe-burn-patients-from-an-industrial-disaster-a-multicenter-retrospective-study
#11
Chenqi Tang, Junqiang Li, Beiming Shou, Bohan Pan, Tiansheng Chen, Yongqiang Xiao, Xiaopeng Zheng, Shichu Xiao, Qian Tan, Zhaofan Xia
OBJECTIVES: To determine the characteristics of bloodstream infections (BSIs) and to evaluate the impact of BSIs on mortality in severe burn patients. METHODS: A retrospective observational study was conducted in 20 tertiary hospitals. A total of 185 Patients who experienced a massive dust explosion in eastern China were included. RESULTS: After exclusion, 177 patients were analyzed. The median total body surface area (TBSA) burned was 95% (interquartile range [IQR], 85%-98%)...
June 19, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28578555/infections-due-to-acinetobacter-baumannii-in-the-icu-treatment-options
#12
Joseph P Lynch, George G Zhanel, Nina M Clark
Bacteria within the genus Acinetobacter (principally A. baumannii-calcoaceticus complex [ABC]) are gram-negative coccobacilli that may cause nosocomial infections in critically ill or debilitated patients (particularly ventilator-associated pneumonia and infections of the bloodstream, urinary tract, and wounds). Treatment of Acinetobacter infections is difficult, as Acinetobacter spp. are intrinsically resistant to multiple antimicrobial agents, and have a remarkable ability to acquire new resistance determinants via mechanisms that include plasmids, transposons, integrons, and resistance islands...
June 2017: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28458799/the-use-of-bloodstream-infection-mortality-to-measure-the-impact-of-antimicrobial-stewardship-interventions-assessing-the-evidence
#13
REVIEW
Sonali Coulter, Jason A Roberts, Krispin Hajkowicz, Kate Halton
This review sets out to evaluate the current evidence on the impact of inappropriate therapy on bloodstream infections (BSI) and associated mortality. Based on the premise that better prescribing practices should result in better patient outcomes, BSI mortality may be a useful metric to evaluate antimicrobial stewardship (AMS) interventions. A systematic search was performed in key medical databases to identify papers published in English between 2005 and 2015 that examined the association between inappropriate prescribing and BSI mortality in adult patients...
March 30, 2017: Infectious Disease Reports
https://www.readbyqxmd.com/read/28448786/microbiological-features-and-clinical-impact-of-the-type-vi-secretion-system-t6ss-in-acinetobacter-baumannii-isolates-causing-bacteremia
#14
Jungok Kim, Ji-Young Lee, Haejeong Lee, Ji Young Choi, Dae Hun Kim, Yu Mi Wi, Kyong Ran Peck, Kwan Soo Ko
We investigated the genetic background and microbiological features of T6SS-positive Acinetobacter baumannii isolates and clinical impact of the T6SS in patients with A. baumannii bacteremia. One hundred and 62 A. baumannii isolates from patients with bacteremia in 2 tertiary-care hospitals in Korea were included in this study. Approximately one-third (51/162, 31.5%) of the A. baumannii clinical isolates possessed the hcp gene, and the hcp-positive isolates were found in several genotypes in multilocus sequence typing...
April 27, 2017: Virulence
https://www.readbyqxmd.com/read/28448572/clonality-virulence-determinants-and-profiles-of-resistance-of-clinical-acinetobacter-baumannii-isolates-obtained-from-a-spanish-hospital
#15
Elias Dahdouh, Rosa Gómez-Gil, Sonsoles Pacho, Jesús Mingorance, Ziad Daoud, Monica Suárez
INTRODUCTION: Acinetobacter baumannii is a nosocomial pathogen that is showing increasing rates of carbapenem resistance. Multi-Drug Resistant (MDR) International Clones (ICs), associated with certain oxacillinases, are being reported globally. This organism also harbors numerous virulence determinants. In this study, we aim at characterizing A. baumannii isolated from a Spanish hospital in terms of antimicrobial susceptibility, clonality, carbapenemase genes harbored, and virulence determinants expressed...
2017: PloS One
https://www.readbyqxmd.com/read/28408938/bacteraemia-in-intensive-care-unit-clinical-bacteriological-and-prognostic-prospective-study
#16
Zineb Lachhab, Mohammed Frikh, Adil Maleb, Jalal Kasouati, Nouafal Doghmi, Yassine Ben Lahlou, Bouchra Belefquih, Abdelhay Lemnouer, Mostafa Elouennass
Objectives. We conducted a one-year observational study from December 2012 to November 2013 to describe the epidemiology of bacteraemia in intensive care units (ICU) of Mohammed V Military Teaching Hospital of Rabat (Morocco). Methods. The study consisted of monitoring all blood cultures coming from intensive care units and studying the bacteriological profile of positive blood cultures as well as their clinical significance. Results. During this period, a total of 46 episodes of bacteraemia occurred, which corresponds to a rate of 15,4/1000 patients...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/28325579/burden-of-healthcare-associated-infections-in-china-results-of-the-2015-point-prevalence-survey-in-dong-guan-city
#17
J Wang, J Hu, S Harbarth, D Pittet, M Zhou, W Zingg
BACKGROUND: Healthcare-associated infections (HCAIs) are a major health threat. There are few data about HCAI and antibiotic use in the People's Republic of China in the English literature. AIM: To describe and discuss the prevalence of HCAI and antibiotic use from the 2015 point prevalence survey (PPS) in Dong Guan City. METHODS: In 2015, the Dong Guan (City) Nosocomial Infection Control and Quality Improvement Centre organized its yearly PPS in the secondary and tertiary care hospitals of Dong Guan City...
February 17, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28287300/clinical-and-molecular-epidemiology-of-acinetobacter-baumannii-bloodstream-infections-in-an-endemic-setting
#18
Dror Marchaim, Dana Levit, Roy Zigron, Michal Gordon, Tsillia Lazarovitch, Joao A Carrico, Vered Chalifa-Caspi, Jacob Moran-Gilad
AIM: The transmission dynamics of Acinetobacter baumannii in endemic settings, and the relation between microbial properties and patients' clinical outcomes, are yet obscure and hampered by insufficient metadata. METHODS & RESULTS: Of 20 consecutive patients with A. baumannii bloodstream infection that were thoroughly analyzed at a single center, at least one transmission opportunity was evident for 85% of patients. This implies that patient-to-patient transmission is the major mode of A...
March 2017: Future Microbiology
https://www.readbyqxmd.com/read/28139542/an-audit-of-colistin-use-in-neonatal-sepsis-from-a-tertiary-care-centre-of-a-resource-limited-country
#19
Bonny Jasani, Sridharan Kannan, Ruchi Nanavati, Nithya J Gogtay, Urmila Thatte
BACKGROUND & OBJECTIVES: Sepsis due to multidrug-resistant Gram-negative pathogens is a challenge for clinicians and microbiologists and has led to use of parenteral colistin. There is a paucity of data regarding safety and efficacy of intravenous colistin use in neonates. The objective of this retrospective analysis was to study the efficacy and safety of intravenous colistin in the treatment of neonatal sepsis. METHODS: An audit of the data from neonates, admitted to a neonatal intensive care unit of a tertiary care hospital during January 2012 to December 2012, and who received intravenous colistin was carried out...
September 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28109554/clinical-and-microbiological-characteristics-of-bloodstream-infections-among-patients-with-haematological-malignancies-with-and-without-neutropenia-at-a-medical-centre-in-northern-taiwan-2008-2013
#20
Chien-Yuan Chen, Feng-Ming Tien, Wang-Huei Sheng, Shang-Yi Huang, Ming Yao, Jih-Luh Tang, Woei Tsay, Hwei-Fang Tien, Po-Ren Hsueh
This study aimed to investigate the epidemiology and microbiology of bloodstream infections (BSIs) in patients with haematological malignancies. Clinical characteristics and microbiology of 2083 patients with haematological malignancy who were treated for BSI from 2008 to 2013 at a medical centre in Taiwan were retrospectively reviewed. Lymphoma (38.1%) was the most common, followed by acute myeloid leukaemia (30.9%). Of the 2090 non-duplicate BSI isolates, 1310 (62.7%) were recovered from patients with neutropenia...
March 2017: International Journal of Antimicrobial Agents
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