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acinetobacter baumannii bloodstream infections

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https://www.readbyqxmd.com/read/29751127/temporal-trends-and-patterns-in-antimicrobial-resistant-gram-negative-bacteria-implicated-in-intensive-care-unit-acquired-infections-a-cohort-based-surveillance-study-in-istanbul-turkey
#1
Bulent Durdu, Evangelos I Kritsotakis, Andrew C K Lee, Perihan Torun, Ismail N Hakyemez, Bilge Gultepe, Turan Aslan
OBJECTIVES: This study assessed trends and patterns in antimicrobial resistant intensive care unit (ICU)-acquired infections caused by Gram-negative bacteria (GNB) in Istanbul, Turkey. METHODS: Bacterial culture and antibiotic susceptibility data were collected for all GNB causing nosocomial infections in five adult ICUs of a large university hospital during 2012-2015. Multi-resistance patterns were categorised as multidrug (MDR), extensively-drug (XDR) and pandrug (PDR)-resistance...
May 8, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29737964/identification-of-acinetobacter-seifertii-isolated-from-bolivian-hospitals
#2
Mónica Cerezales, Kyriaki Xanthopoulou, Julia Ertel, Alexandr Nemec, Zulema Bustamante, Harald Seifert, Lucia Gallego, Paul G Higgins
Acinetobacter seifertii is a recently described species that belongs to the Acinetobacter calcoaceticus-Acinetobacter baumannii complex. It has been recovered from clinical samples and is sometimes associated with antimicrobial resistance determinants. We present here the case of three A. seifertii clinical isolates which were initially identified as Acinetobacter sp. by phenotypic methods but no identification at the species level was achieved using semi-automated identification methods. The isolates were further analysed by whole genome sequencing and identified as A...
May 8, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29707660/changes-in-the-incidence-and-antimicrobial-susceptibility-of-healthcare-associated-infections-in-a-new-york-hospital-system-2006-2012
#3
B Cohen, J Liu, E Larson
Introduction: National efforts to curtail healthcare-associated infections (HAI) proliferated recently, though data detailing progress over time are limited. This retrospective cohort study aims to describe changes in incidence and antimicrobial susceptibility of HAI in four New York City hospitals over seven years. Methods: Electronic data were collected retrospectively for all patients discharged from 2006 through 2012. Previously validated computerized algorithms based on National Healthcare Safety Network criteria detected bloodstream infections, pneumonia, surgical site infections, and urinary tract infections with Enterococcus spp...
December 2017: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/29693659/a-high-frequency-phenotypic-switch-links-bacterial-virulence-and-environmental-survival-in-acinetobacter-baumannii
#4
Chui Yoke Chin, Kyle A Tipton, Marjan Farokhyfar, Eileen M Burd, David S Weiss, Philip N Rather
Antibiotic-resistant infections lead to 700,000 deaths per year worldwide 1 . The roles of phenotypically diverse subpopulations of clonal bacteria in the progression of diseases are unclear. We found that the increasingly pathogenic and antibiotic-resistant pathogen Acinetobacter baumannii harbours a highly virulent subpopulation of cells responsible for disease. This virulent subpopulation possesses a thicker capsule and is resistant to host antimicrobials, which drive its enrichment during infection. Importantly, bacteria harvested from the bloodstream of human patients belong exclusively to this virulent subpopulation...
May 2018: Nature Microbiology
https://www.readbyqxmd.com/read/29667378/alarming-results-of-nosocomial-infections-in-a-multicenter-program-of-surveillance-in-polish-intensive-care-units
#5
Michał Wałaszek, Anna Różańska, Małgorzata Bulanda, Jadwiga Wojkowska-Mach, Polish Society of Hospital Infections Team
INTRODUCTION: Nosocomial bloodstream infections (BSI) among patients in intensive care units (ICU) are the most common form of nosocomial infections and they are serious complications of the treatment process. The etiological factors of these infections and the proper antibiotic therapy can influence the effects of patient treatment. The aim of the study was to analyze the epidemiology, microbiology and antibiotic therapy of nosocomial BSI in Polish ICU patients. MATERIALS AND METHODS: The retrospective study covered patients hospitalized in seven ICUs for adults with a general profile, located in southern Poland...
2018: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29649276/carbapenem-resistant-gram-negative-pathogens-in-a-german-university-medical-center-prevalence-clinical-implications-and-the-role-of-novel-%C3%AE-lactam-%C3%AE-lactamase-inhibitor-combinations
#6
Juri Katchanov, Lucia Asar, Eva-Maria Klupp, Anna Both, Camilla Rothe, Christina König, Holger Rohde, Stefan Kluge, Florian P Maurer
OBJECTIVES: To determine the spectrum of infections with multidrug-resistant Gram-negative bacteria (MDR-GNB) and the clinical impact of the newly available betalactam/betalactamase inhibitor combinations ceftolozane/tazobactam and ceftazidime/avibactam in a German academic tertiary care center. METHODS: Retrospective analysis. RESULTS: Between September 1, 2015 and August 31, 2016, 119 individual patients (0.22% of all hospital admissions) were colonized or infected with carbapenem-resistant MDR-GNB...
2018: PloS One
https://www.readbyqxmd.com/read/29630127/research-and-analysis-of-74-bloodstream-infection-cases-of-acinetobacter-baumannii-and-drug-resistance
#7
H-G Wu, W-S Liu, M Zhu, X-X Li
OBJECTIVE: We aimed at investigating the clinical and bacteriological features and drug resistance of bloodstream infection of Acinetobacter baumannii, so as to provide new evidence for treatment of bloodstream infection of Acinetobacter baumannii. PATIENTS AND METHODS: Statistical analysis was carried out for the clinical and bacteriological features and drug sensitivity of 74 bloodstream infection cases of Acinetobacter baumannii who were admitted to this hospital between July 2016 and June 2017...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29608754/t2-magnetic-resonance-for-the-diagnosis-of-bloodstream-infections-charting-a-path-forward
#8
Cornelius J Clancy, M Hong Nguyen
We discuss four studies in this issue of the Journal of Antimicrobial Chemotherapy that describe experience with T2 magnetic resonance (T2MR) nanodiagnostics for Candida and bacterial bloodstream infections, in the context of the T2MR literature. T2Candida and T2Bacteria panels use a dedicated instrument to detect amplified DNA from microbial cells directly in whole blood. T2Candida gives positive or negative results for C. albicans/C. tropicalis, C. glabrata/C. krusei, and C. parapsilosis. T2Bacteria detects Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli...
March 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29608753/t2bacteria-magnetic-resonance-assay-for-the-rapid-detection-of-eskapec-pathogens-directly-in-whole-blood
#9
Giulia De Angelis, Brunella Posteraro, Elena De Carolis, Giulia Menchinelli, Francesco Franceschi, Mario Tumbarello, Gennaro De Pascale, Teresa Spanu, Maurizio Sanguinetti
Objectives: To evaluate the magnetic resonance-based T2Bacteria Panel assay for direct detection of ESKAPEc (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli) pathogens in blood samples of patients with suspected bloodstream infection (BSI). Patients and methods: Adult patients admitted to the Emergency Medicine Department, Infectious Diseases Unit and ICU of a large tertiary-care hospital were included if they had a blood culture (BC) ordered concomitantly with a whole-blood sample for T2Bacteria testing...
March 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29577994/acinetobacter-pittii-more-frequently-isolated-than-acinetobacter-baumannii-in-blood-cultures-the-experience-of-a-french-hospital
#10
Hélène Pailhoriès, Clémence Tiry, Matthieu Eveillard, Marie Kempf
This study assessed the characteristics of hospital-acquired Acinetobacter calcoaceticus - Acinetobacter baumannii complex (ACB) bloodstream infections (BSI). From 2010 to 2017, ACB BSI were investigated. Of 73 cases, 54.8% were associated with A. pittii, 39.7% with A. baumannii and 5.5% with A. nosocomialis. MDR isolates were significantly higher in A. baumannii BSI. The 30-day mortality was no different between A. baumannii or non-baumannii ACB BSI. In contrast with other studies, here, most of hospital-acquired ACB BSI were associated with non-baumannii ACB species...
March 22, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29548877/antibiotic-consumption-versus-the-prevalence-of-multidrug-resistant-acinetobacter-baumannii-and-clostridium-difficile-infections-at-an-icu-from-2014-2015
#11
Grzegorz Ziółkowski, Iwona Pawłowska, Lech Krawczyk, Jadwiga Wojkowska-Mach
BACKGROUND: Acinetobacter baumannii strains are currently the most commonly isolated non-fermenting rods at Polish intensive care units (ICUs), and they are the dominant aetiological agents of pneumonia. This study aimed to evaluate the prevalence of A. baumannii isolated from patients who were hospitalised at Sosnowiec Hospital's ICU. We also investigated the drug sensitivity of A. baumannii in relation to antibiotic consumption expressed as the defined daily dose (DDD) and Clostridium difficile infection (CDI)...
March 13, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29533544/severe-infections-caused-by-multidrug-resistant-non-fermentative-bacilli-in-southern-poland
#12
Agnieszka Chmielarczyk, Monika Pobiega, Grzegorz Ziółkowski, Monika Pomorska-Wesołowska, Dorota Romaniszyn, Lech Krawczyk, Jadwiga Wójkowska-Mach
BACKGROUND: The impact of multidrug-resistant organisms (MDROs), including non-fermentative bacilli (NFBs), is rising and underestimated, especially in intensive care units (ICUs). The growing prevalence of multidrug resistance (MDR) and extensive drug resistance (XDR) is challenging for clinicians, as the treatment options are limited. OBJECTIVES: The purpose of this study was to analyze the extent of the epidemiological problem of multidrugresistant, extensively drug-resistant and pandrug-resistant (PDR) non-fermentative bacilli isolated from pneumonia and bloodstream infections (BSIs) in patients hospitalized in southern Poland...
March 13, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29528021/clinical-characteristics-of-acinetobacter-baumannii-infection-in-solid-organ-transplant-recipients
#13
Irem Serifoglu, Balam Er Dedekarginoglu, Serife Savas Bozbas, Sule Akcay, Mehmet Haberal
OBJECTIVES: Acinetobacter baumannii, depending on the immune status of the host, may result in one of the most serious hospital infections. Infections involving A. baumannii infection have been recently rising. However, little is known about the clinical features of A. baumannii infection in solid-organ transplant recipients. We aimed to share our clinical experiences with A. baumannii infection in our transplant recipients. MATERIALS AND METHODS: Between 2011 and 2017, 41 solid-organ transplant patients developed A...
March 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29522784/multi-hospital-point-prevalence-study-of-healthcare-associated-infections-in-28-adult-intensive-care-units-in-brazil
#14
I A Braga, P A Campos, P P Gontijo-Filho, R M Ribas
BACKGROUND: Healthcare-associated infection (HAI) represents a major problem for patient safety worldwide. AIM: To provide an up-to-date picture of the extent, aetiology, risk factors and patterns of infections in intensive care units (ICUs) in 28 Brazilian hospitals of different sizes. METHODS: A one-day point prevalence survey in 2016 enrolled the ICUs of hospitals from the 12 meso-regions in Minas Gerais state, south-east Brazil. Hospitals were classified as university or non-university hospitals...
March 6, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29324651/incidence-microbiological-profile-and-risk-factors-of-healthcare-associated-infections-in-intensive-care-units-a-10-year-observation-in-a-provincial-hospital-in-southern-poland
#15
Małgorzata Kołpa, Marta Wałaszek, Agnieszka Gniadek, Zdzisław Wolak, Wiesław Dobroś
Healthcare-associated infections (HAIs) occurring in patients treated in an intensive care unit (ICU) are serious complications in the treatment process. Aetiological factors of these infections can have an impact on treatment effects, treatment duration and mortality. The aim of the study was to determine the prevalence and microbiological profile of HAIs in patients hospitalized in an ICU over a span of 10 years. The active surveillance method was used to detect HAIs in adult patients who spent over 48 h in a general ICU ward located in southern Poland between 2007 and 2016...
January 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29317913/prevalence-and-risk-factors-for-bloodstream-infection-present-on-hospital-admission
#16
Sainfer Aliyu, Bevin Cohen, Jianfang Liu, Elaine Larson
Background: Bloodstream infection present on hospital admission (BSI-POA) is a major cause of morbidity and mortality. The purpose of this study was to measure prevalence and describe the risk factors of patients with BSI-POA and to determine the prevalence of resistance in isolates by admission source. Methods: We conducted a retrospective cohort study of patients discharged from three hospitals in New York City between 2006 and 2014. BSI-POA was defined as BSI diagnosed within 48 h of hospitalisation...
January 2018: Journal of Infection Prevention
https://www.readbyqxmd.com/read/29249812/uncovering-the-mechanisms-of-acinetobacter-baumannii-virulence
#17
REVIEW
Christian M Harding, Seth W Hennon, Mario F Feldman
Acinetobacter baumannii is a nosocomial pathogen that causes ventilator-associated as well as bloodstream infections in critically ill patients, and the spread of multidrug-resistant Acinetobacter strains is cause for concern. Much of the success of A. baumannii can be directly attributed to its plastic genome, which rapidly mutates when faced with adversity and stress. However, fundamental virulence mechanisms beyond canonical drug resistance were recently uncovered that enable A. baumannii and, to a limited extent, other medically relevant Acinetobacter species to successfully thrive in the health-care environment...
February 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/29248504/rapid-emergence-of-colistin-resistance-and-its-impact-on-fatality-among-healthcare-associated-infections
#18
M Aydın, Ö Ergönül, A Azap, H Bilgin, G Aydın, S A Çavuş, Y Z Demiroğlu, H E Alışkan, O Memikoğlu, Ş Menekşe, Ş Kaya, N A Demir, I Karaoğlan, S Başaran, Ç Hatipoğlu, Ş Erdinç, E Yılmaz, A Tümtürk, Y Tezer, H Demirkaya, Ş E Çakar, Ş Keske, S Tekin, C Yardımcı, Ç Karakoç, P Ergen, Ö Azap, L Mülazımoğlu, O Ural, F Can, H Akalın
This article describes the emergence of resistance and predictors of fatality for 1556 cases of healthcare-associated Gram-negative bloodstream infection in 2014 and 2015. The colistin resistance rate in Klebsiella pneumoniae was 16.1%, compared with 6% in 2013. In total, 660 (42.4%) cases were fatal. The highest fatality rate was among patients with Acinetobacter baumannii bacteraemia (58%), followed by Pseudomonas aeruginosa (45%), Klebsiella pneumoniae (41%), Enterobacter cloacae (32%) and Escherichia coli (28%)...
March 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29122697/early-administration-of-appropriate-antimicrobial-agents-to-improve-the-outcome-of-carbapenem-resistant-acinetobacter-baumannii-complex-bacteraemic-pneumonia
#19
Seong Yeon Park, Eun Jung Lee, Tark Kim, Shi Nae Yu, Ki-Ho Park, Mi Suk Lee, Se Yoon Park, Min Hyok Jeon, Tae Hyong Kim, Eun Ju Choo
Carbapenem-resistant Acinetobacter baumannii complex (CRABC) is an emerging pathogen that causes bloodstream infections and nosocomial pneumonia. This study aimed to describe severe infection associated with CRABC bacteraemic pneumonia and to investigate risk factors for 28-day mortality. All patients aged ≥18 years with CRABC bacteraemic pneumonia were enrolled retrospectively at five teaching hospitals in South Korea. Empirical antimicrobial therapy was defined as appropriate if administration of at least one antimicrobial agent, to which the causative pathogen was susceptible, for >48 h, within 5 days of the onset of bacteraemia...
March 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29069421/comparative-efficacy-and-safety-of-treatment-options-for-mdr-and-xdr-acinetobacter-baumannii-infections-a-systematic-review-and-network-meta-analysis
#20
Kirati Kengkla, Khachen Kongpakwattana, Surasak Saokaew, Anucha Apisarnthanarak, Nathorn Chaiyakunapruk
Objectives: To comprehensively compare and rank the efficacy and safety of available treatment options for patients with MDR and XDR Acinetobacter baumannii (AB) infection. Methods: We searched PubMed, Embase and the Cochrane register of trials systematically for studies that examined treatment options for patients with MDR- and XDR-AB infections until April 2016. Network meta-analysis (NMA) was performed to estimate the risk ratio (RR) and 95% CI from both direct and indirect evidence...
January 1, 2018: Journal of Antimicrobial Chemotherapy
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