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https://www.readbyqxmd.com/read/29234385/the-immediate-analgesic-effect-of-acupuncture-for-pain-a-systematic-review-and-meta-analysis
#1
REVIEW
Anfeng Xiang, Ke Cheng, Xueyong Shen, Ping Xu, Sheng Liu
Although acupuncture is gaining popularity for the treatment of nonspecific pain, the immediate analgesic effect of acupuncture has never been reviewed. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) on disease-related pain to critically evaluate the immediate effect of acupuncture for pain relief. The PubMed and Cochrane Central Register of Controlled Trials databases as well as three Chinese databases including the China National Knowledge Infrastructure (CNKI), Wanfang, and VIP platforms were searched through November 2016...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29230910/estimating-causal-effects-for-survival-time-to-event-outcomes-by-combining-classification-tree-analysis-and-propensity-score-weighting
#2
Ariel Linden, Paul R Yarnold
RATIONALE, AIMS AND OBJECTIVES: A common approach to assessing treatment effects in nonrandomized studies with time-to-event outcomes is to estimate propensity scores and compute weights using logistic regression, test for covariate balance, and then estimate treatment effects using Cox regression. A machine-learning alternative-classification tree analysis (CTA)-used to generate propensity scores and to estimate treatment effects in time-to-event data may identify complex relationships between covariates not found using conventional regression-based approaches...
December 12, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29225658/intraspecific-eye-color-variability-in-birds-and-mammals-a-recent-evolutionary-event-exclusive-to-humans-and-domestic-animals
#3
Juan J Negro, M Carmen Blázquez, Ismael Galván
Background: Human populations and breeds of domestic animals are composed of individuals with a multiplicity of eye (= iris) colorations. Some wild birds and mammals may have intraspecific eye color variability, but this variation seems to be due to the developmental stage of the individual, its breeding status, and/or sexual dimorphism. In other words, eye colour tends to be a species-specific trait in wild animals, and the exceptions are species in which individuals of the same age group or gender all develop the same eye colour...
2017: Frontiers in Zoology
https://www.readbyqxmd.com/read/29225295/effect-of-smoking-status-on-monocyte-tissue-factor-activity-carotid-atherosclerosis-and-long-term-prognosis-in-metabolic-syndrome
#4
Keiichi Kohashi, Akihiro Nakagomi, Taichirou Morisawa, Ikuko Endoh, Naomi Kawaguchi, Yoshiki Kusama, Wataru Shimizu
BACKGROUND: Smoking increases the risk of atherothrombotic events. Tissue factor (TF) mainly expressed on monocytes plays an important role in thrombosis and atherosclerosis. Metabolic syndrome (MetS) is being increasingly recognized as a major atherothrombotic risk factor, but the effects of smoking on monocyte TF activity (MTFA), carotid atherosclerosis estimated on carotid intima-media thickness (CIMT), and long-term prognosis in MetS remain unclear.Methods and Results:A total of 301 MetS patients lacking any known cardiovascular disease were prospectively investigated and classified into 4 groups according to smoking status at entry and at 12 months as follows: never smokers, past smokers, quitters, and persistent smokers...
December 9, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29219562/force-and-mass-dynamics-in-non-newtonian-suspensions
#5
Melody X Lim, Jonathan Barés, Hu Zheng, Robert P Behringer
Above a certain solid fraction, dense granular suspensions in water exhibit non-Newtonian behavior, including impact-activated solidification. Although it has been suggested that solidification depends on boundary interactions, quantitative experiments on the boundary forces have not been reported. Using high-speed video, tracer particles, and photoelastic boundaries, we determine the impactor kinematics and the magnitude and timings of impactor-driven events in the body and at the boundaries of cornstarch suspensions...
November 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29218766/risk-of-recurrent-severe-hypoglycemia-remains-associated-with-a-past-history-of-severe-hypoglycemia-up-to-4%C3%A2-years-results-from-a-large-prospective-contemporary-pediatric-cohort-of-the-dpv-initiative
#6
D Pacaud, J M Hermann, B Karges, J Rosenbauer, T Danne, R Dürr, A Herbst, S Lindauer, S Müther, S Pötzsch, K Raile, M Witsch, R W Holl
OBJECTIVES: In a contemporary cohort of youth with type 1 diabetes, we examined the interval between episodes of severe hypoglycemia (SH) as a risk factor for recurrent SH or hypoglycemic coma (HC). METHODS: This was a large longitudinal observational study. Using the DPV Diabetes Prospective follow-up data, we analyzed frequency and timing of recurrent SH (defined as requiring assistance from another person) and HC (loss of consciousness or seizures) in 14 177 youths with type 1 diabetes aged <20 years and at least 5 years of follow-up...
December 8, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29218705/randomized-controlled-study-comparing-the-efficacy-of-rapid-and-slow-withdrawal-of-antiepileptic-drugs-during-long-term-video-eeg-monitoring
#7
Shambhu Kumar, Bhargavi Ramanujam, P S Chandra, Deepa Dash, Santosh Mehta, Sharma Anubha, Renjith Appukutan, Manit Kumar Rana, Manjari Tripathi
OBJECTIVE: Antiepileptic drugs (AEDs) are routinely withdrawn during long-term video-electroencephalography (EEG) monitoring (LTM), to record sufficient number of seizures. The efficacy of rapid and slow AED taper has never been compared in a randomized control trial (RCT), which was the objective of this study. METHODS: In this open-label RCT, patients aged 2-80 years with drug-resistant epilepsy (DRE) were randomly assigned (1:1) to rapid and slow AED taper groups...
December 7, 2017: Epilepsia
https://www.readbyqxmd.com/read/29218290/critical-upper-limb-ischemia-due-to-brachial-tourniquet-in-misdiagnosed-thoracic-outlet-syndrome-after-carpal-tunnel-decompression-a-case-report
#8
Cesare Tiengo, Andrea Monticelli, Stefano Bonvini, Valentina Wassermann, Erica Dalla Venezia, Franco Bassetto
We present the case of a 68-year-old woman, referred to our department for critical upper limb ischemia, which had occurred a few days after homolateral surgical ligamentotomy for carpal tunnel syndrome, diagnosed and confirmed by electromyography, and performed with a brachial tourniquet. The patient was later admitted for subsequent progressive necrosis of the first three fingers of the left hand, accompanied by signs of upper limb ischemia. An accessory cervical rib was identified, completely obliterating the subclavian artery distally at the origin of the suprascapular artery...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29217530/the-impact-of-smoking-and-tp53-mutations-in-lung-adenocarcinoma-patients-with-targetable-mutations-the-lung-cancer-mutation-consortium-lcmc2
#9
Dara L Aisner, Lynette M Sholl, Lynne Berry, Michael Rossi, Heidi Chen, Junya Fujimoto, Andre L Moreira, Suresh Ramalingam, Liza C Villaruz, Gregory A Otterson, Eric B Haura, Katerina Politi, Bonnie S Glisson, Jeremy Cetnar, Edward Garon, Joan Schiller, Saiama Waqar, Lecia V Sequist, Julie R Brahmer, Yu Shyr, Kelly Kugler, Ignacio Ivan Wistuba, Bruce E Johnson, John D Minna, Mark G Kris, Paul A Bunn, David J Kwiatkowski
PURPOSE Multiplex genomic profiling is standard of care for patients with advanced lung adenocarcinomas. The Lung Cancer Mutation Consortium (LCMC) is a multi-institutional effort to identify and treat oncogenic driver events in patients with lung adenocarcinomas. PATIENTS AND METHODS Sixteen U.S. institutions enrolled 1367 lung cancer patients in LCMC2; 904 were deemed eligible and had at least one of 14 cancer-related genes profiled using validated methods including genotyping, massively parallel sequencing, and immunohistochemistry...
December 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29214630/a-del-phenotype-attributed-to-rhd-exon-9-sequence-deletion-slipped-strand-mispairing-and-blood-group-polymorphisms
#10
Genghis H Lopez, Robyn M Turner, Eunike C McGowan, Elizna M Schoeman, Stacy A Scott, Helen O'Brien, Glenda M Millard, Eileen V Roulis, Amanda J Allen, Yew-Wah Liew, Robert L Flower, Catherine A Hyland
BACKGROUND: The RhD blood group antigen is extremely polymorphic and the DEL phenotype represents one such class of polymorphisms. The DEL phenotype prevalent in East Asian populations arises from a synonymous substitution defined as RHD*1227A. However, initially, based on genomic and cDNA studies, the genetic basis for a DEL phenotype in Taiwan was attributed to a deletion of RHD Exon 9 that was never verified at the genomic level by any other independent group. Here we investigate the genetic basis for a Caucasian donor with a DEL partial D phenotype and compare the genomic findings to those initial molecular studies...
December 6, 2017: Transfusion
https://www.readbyqxmd.com/read/29209525/final-results-of-the-large-scale-multinational-trial-profile-1005-efficacy-and-safety-of-crizotinib-in-previously-treated-patients-with-advanced-metastatic-alk-positive-non-small-cell-lung-cancer
#11
Fiona Blackhall, D Ross Camidge, Alice T Shaw, Jean-Charles Soria, Benjamin J Solomon, Tony Mok, Vera Hirsh, Pasi A Jänne, Yuankai Shi, Pan-Chyr Yang, Tommaso De Pas, Toyoaki Hida, Javier De Castro Carpeño, Silvana Lanzalone, Anna Polli, Shrividya Iyer, Arlene Reisman, Keith D Wilner, Dong-Wan Kim
Purpose: Crizotinib is a potent, orally administered tyrosine kinase inhibitor approved for the treatment of anaplastic lymphoma kinase (ALK)-positive advanced non-small-cell lung cancer (NSCLC). We report final results from PROFILE 1005, the largest clinical trial to date for an ALK inhibitor in ALK-positive NSCLC. Patients and methods: PROFILE 1005 (NCT00932451) was a multicenter, single-arm phase 2 trial of the efficacy, safety and tolerability of crizotinib (250 mg twice daily; 3 week continuous treatment cycles) in patients with ALK-positive NSCLC after failure of ≥1 lines of systemic treatment for locally advanced/metastatic disease...
2017: ESMO Open
https://www.readbyqxmd.com/read/29207941/uneven-acute-non-alcoholic-fatty-change-of-the-liver-after-percutaneous-transhepatic-portal-vein-embolization-in-a-patient-with-hilar-cholangiocarcinoma-a-case-report
#12
Chun-Yi Tsai, Motoi Nojiri, Yukihiro Yokoyama, Tomoki Ebata, Takashi Mizuno, Masato Nagino
BACKGROUND: Portal vein embolization is essential for patients with biliary cancer who undergo extended hepatectomy to induce hypertrophy of the future remnant liver. Over 830 patients have undergone the portal vein embolization at our institution since 1990. Non-alcoholic fatty liver disease is an entity of hepatic disease characterized by fat deposition in hepatocytes. It has a higher prevalence among persons with morbid obesity, type 2 diabetes, and hyperlipidemia. Neither the mechanism of hepatic hypertrophy after portal vein embolization nor the pathophysiology of non-alcoholic fatty liver disease has been fully elucidated...
December 6, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29206720/recruitment-of-female-sex-workers-in-hiv-prevention-trials-can-efficacy-endpoints-be-reached-more-efficiently
#13
Daniel Wood, Kathryn E Lancaster, Marie-Claude Boily, Kimberly A Powers, Deborah Donnell, Myron S Cohen, Dobromir T Dimitrov
Background/Setting: Randomized controlled trials (RCTs) of HIV biomedical prevention interventions often enroll participants with varying levels of HIV exposure, including people never exposed to HIV. We assessed whether enrolling larger proportion of participants with consistently high exposure to HIV, such as female sex workers (FSW), might reduce trial duration and improve the accuracy of product efficacy estimates in future HIV prevention trials. METHODS: We used an individual-based stochastic model to simulate event-driven RCTs of an HIV prevention intervention providing 80% reduction in susceptibility per act under different proportions of FSW enrolled...
November 28, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29206625/effect-of-mir-204-211-and-runx2-control-on-the-fate-of-human-mesenchymal-stromal-cells
#14
Benedetto Sacchetti, Alessandro Fatica, Melissa Sorci, Antonio Sorrentino, Michele Signore, Annamaria Cerio, Federica Felicetti, Alessandra De Feo, Elvira Pelosi, Alessandra Caré, Edoardo Pescarmona, Jan Oxholm Gordeladze, Mauro Valtieri
MiR-204 and 211 enforced expression in murine mesenchymal stromal cells (MSCs) has been shown to induce adipogenesis and impair osteogenesis, through RUNX2 down-modulation. This mechanism has been suggested to play a role in osteoporosis associated with obesity. However, two further fundamental MSC functions, chondrogenesis and hematopoietic supporting activity, have not yet been explored. To this end, we transduced, by a lenti-viral vector, miR-204 and 211 in a model primary human MSC line, opportunely chosen among our MSC collection for displaying all properties of canonical bone marrow MSCs, except adipogenesis...
2017: Regenerative Medicine Research
https://www.readbyqxmd.com/read/29203808/association-between-smoking-and-the-peripheral-vestibular-disorder-a-retrospective-cohort-study
#15
Masaoki Wada, Taro Takeshima, Yosikazu Nakamura, Shoichiro Nagasaka, Toyomi Kamesaki, Eiji Kajii, Kazuhiko Kotani
Common inner ear diseases include peripheral vestibular disorder (PVD) and hearing impairment. The association between smoking and peripheral vestibular disorder (PVD) is unclear. We examined associations between smoking and new PVD events. In this retrospective study, we consecutively enrolled 393 participants aged ≥20 years [mean age 65.3 years; males 133 (33.8%)] treated for hypertension, dyslipidaemia, or diabetes mellitus at a primary care clinic between November 2011 and March 2013. Participants were categorized as ever-smokers (including current and past -smokers; divided per <30 and ≥30 pack-years), and never-smokers...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29198653/acceptance-of-gold-medal-from-the-catalan-society-of-transplantation-by-drs-lorraine-racusen-and-kim-solez-with-remarks-on-the-banff-meeting-spirit
#16
L C Racusen, K Solez
The awarding of the gold medal from the Catalan Society of Transplantation to the organizers of the Banff Transplant Pathology meetings is an opportunity to acknowledge gratitude to all the people who have helped make these meetings a success over the past 26 years. Other large organizations have given up consensus conferences, but the Banff consensus process is thriving. It is unusual for any organization to have the same leadership for 26 years. It has only worked for the Banff meetings because the leadership was flexible and able to change with the times...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29198490/overdose-and-adverse-drug-event-experiences-among-adult-patients-in-the-emergency-department
#17
Amy S B Bohnert, Maureen A Walton, Rebecca M Cunningham, Mark A Ilgen, Kristen Barry, Stephen T Chermack, Frederic C Blow
INTRODUCTION: Overdose is a leading cause of injury and death in the United States. Emergency Department (ED) patients have an elevated prevalence of substance use. This study describes overdose/adverse drug event experiences among adult ED patients to inform strategies to address overdose risk. METHODS: Patients seeking care at a large ED in the city of Flint, Michigan participated in a computerized self-assessment during 2011-2013 (n=4571). Overdose was assessed with a broad definition and included occurrences that could be considered adverse drug events...
November 16, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29192000/drooling-reduction-intervention-randomised-trial-dri-comparing-the-efficacy-and-acceptability-of-hyoscine-patches-and-glycopyrronium-liquid-on-drooling-in-children-with-neurodisability
#18
Jeremy R Parr, Emma Todhunter, Lindsay Pennington, Deborah Stocken, Jill Cadwgan, Anne E O'Hare, Catherine Tuffrey, Jane Williams, Mike Cole, Allan F Colver
OBJECTIVE: Investigate whether hyoscine patch or glycopyrronium liquid is more effective and acceptable to treat drooling in children with neurodisability. DESIGN: Multicentre, single-blind, randomised controlled trial. SETTING: Recruitment through neurodisability teams; treatment by parents. PARTICIPANTS: Ninety children with neurodisability who had never received medication for drooling (55 boys, 35 girls; median age 4 years)...
November 30, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29190955/concurrent-administration-of-trastuzumab-and-anthracyclines-as-adjuvant-regimen-for-her2-positive-breast-cancer-a-randomised-controlled-trial
#19
Songjie Shen, Ying Xu, Yidong Zhou, Feng Mao, Jinghong Guan, Qiang Sun
Background: The regimen of concurrent administration of trastuzumab and anthracyclines in the adjuvant treatment of breast cancer has never been evaluated prospectively for fear of cardiac toxicity. Methods: Patients with HER2-positive operable breast cancer were randomised to receive adjuvant treatment with concurrent or sequential administration of trastuzumab and anthracyclines. Cardiac monitoring was scheduled at baseline and every 3 months after the first dose of trastuzumab...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29186411/late-onset-of-pneumothorax-after-bronchoscopic-lung-volume-reduction-due-to-migration-of-a-nitinol-coil
#20
Francesco Mongelli, Stefano Cafarotti, Matteo Di Giuseppe, Miriam Patella
The use of Endobronchial coils are a relatively new brochoscopic technique for lung volume reduction. They appear to be safe and effective in improving quality of life, reducing morbidity and mortality related to the primary disease, while avoiding the many risks of morbidity and mortality associated with surgery. Nevertheless, some complications, such as pneumothorax, are relatively common in the periprocedural period. We describe a case of pneumothorax that occurred several days after brochoscopic technique for lung volume reduction due to direct perforation of the visceral pleura by a coil...
November 27, 2017: European Journal of Cardio-thoracic Surgery
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