keyword
MENU ▼
Read by QxMD icon Read
search

Never events

keyword
https://www.readbyqxmd.com/read/29030804/a-multi-stage-representation-of-cell-proliferation-as-a-markov-process
#1
Christian A Yates, Matthew J Ford, Richard L Mort
The stochastic simulation algorithm commonly known as Gillespie's algorithm (originally derived for modelling well-mixed systems of chemical reactions) is now used ubiquitously in the modelling of biological processes in which stochastic effects play an important role. In well-mixed scenarios at the sub-cellular level it is often reasonable to assume that times between successive reaction/interaction events are exponentially distributed and can be appropriately modelled as a Markov process and hence simulated by the Gillespie algorithm...
October 13, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29027083/objective-and-subjective-results-following-implantation-of-the-finevision-trifocal-intraocular-lens-in-mexican-patients
#2
Ivo Ferreira-Ríos, Karla Zuñiga-Posselt, Juan Carlos Serna-Ojeda, Eduardo Chávez-Mondragón
PURPOSE: To evaluate objective and subjective results after bilateral implantation of a diffractive trifocal intraocular lens (IOL) in a Mexican population. METHODS: Prospective, interventional case series involved 15 cataract surgery patients who underwent bilateral implantation of the trifocal Micro F lens FineVision IOL (PhysIOL, Liège, Belgium). Objective analysis involved assessment of monocular uncorrected distance (UDVA), near (UNVA) at 30 and 40 cm, and intermediate visual acuity (UIVA) at 50, 60, and 70 cm, preoperatively, and at postoperative months 1, 3, and 6...
October 12, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29024286/modelling-cumulative-exposure-for-inference-about-drug-effects-in-observational-studies
#3
Bassam Farran, Stuart McGurnaghan, Helen C Looker, Shona Livingstone, Eva Lahnsteiner, Helen M Colhoun, Paul M McKeigue
PURPOSE: To demonstrate a modelling approach that controls for time-invariant allocation bias in estimation of associations of outcome with drug exposure. METHODS: We show that in a model that includes terms for both ever-exposure versus never-exposure and cumulative exposure, the parameter for ever-exposure represents the effect of time-invariant allocation bias, and the parameter for cumulative exposure represents the effect of the drug after adjustment for this unmeasured confounding...
October 12, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29020850/household-food-security-and-hiv-status-in-rural-and-urban-communities-in-the-free-state-province-south-africa
#4
Michélle Pienaar, Francois C van Rooyen, Corinna M Walsh
Higher socioeconomic status impacts profoundly on quality of life. Life-event stressors, such as loss of employment, marital separation/divorce, death of a spouse and food insecurity, have been found to accelerate disease progression among people with human immunodeficiency virus (HIV). The objective of this study was to determine significant independent sociodemographic and food security factors associated with HIV status in people from rural and urban communities in the Assuring Health for All study, which was undertaken in rural Trompsburg, Philippolis and Springfontein and urban Mangaung, in the Free State Province of South Africa...
December 2017: SAHARA J: Journal of Social Aspects of HIV/AIDS Research Alliance
https://www.readbyqxmd.com/read/29020374/asian-dust-exposure-triggers-acute-myocardial-infarction
#5
Sunao Kojima, Takehiro Michikawa, Kayo Ueda, Tetsuo Sakamoto, Kunihiko Matsui, Tomoko Kojima, Kenichi Tsujita, Hisao Ogawa, Hiroshi Nitta, Akinori Takami
Aims: To elucidate whether Asian dust is associated with the incidence of acute myocardial infarction (AMI) and to clarify whether patients who are highly sensitive to Asian dust will develop AMI. Methods and results: Twenty-one participating institutions located throughout Kumamoto Prefecture and capable of performing coronary intervention were included in the study. Data for ground-level observations of Asian dust events were measured at the Kumamoto Local Meteorological Observatory...
August 29, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29018566/risks-of-smoking-and-benefits-of-smoking-cessation-on-hospitalisations-for-cardiovascular-events-and-respiratory-infection-in-patients-with-rheumatoid-arthritis-a-retrospective-cohort-study-using-the-clinical-practice-research-datalink
#6
Rebecca M Joseph, Mohammad Movahedi, William G Dixon, Deborah Pm Symmons
OBJECTIVES: To investigate the associations between smoking status, smoking cessation and hospitalisations for cardiovascular events (CVE) and respiratory tract infections (RTI) in an inception cohort of patients with rheumatoid arthritis (RA). METHODS: The study was set within UK primary care electronic health records (the Clinical Practice Research Datalink) linked to hospital inpatient data (Hospital Episode Statistics). Patients with RA were followed from diagnosis to hospitalisation with a record of CVE or RTI, leaving their general practice, death, or 10 January 2012, whichever was earliest...
2017: RMD Open
https://www.readbyqxmd.com/read/29018094/substrate-induced-conformational-changes-in-the-nucleotide-binding-domains-of-lipid-bilayer-associated-p-glycoprotein-during-atp-hydrolysis
#7
Maria E Zoghbi, Leo Mok, Douglas J Swartz, Anukriti Singh, Gregory A Fendley, Ina L Urbatsch, Guillermo A Altenberg
P-glycoprotein (Pgp) is an efflux pump important in multidrug resistance of cancer cells and in determining drug pharmacokinetics. Pgp is a prototype ATP-binding cassette (ABC) transporter with two nucleotide-binding domains (NBDs) that bind and hydrolyze ATP. Conformational changes at the NBDs (the Pgp engines) lead to changes across Pgp transmembrane domains that result in substrate translocation. According to current alternating access models (substrate binding pocket accessible only to one side of the membrane at a time) binding of ATP promotes NBD dimerization, resulting in external accessibility of the drug-binding site (outward-facing, closed NBD conformation), and ATP-hydrolysis leads to dissociation of the NBDs with the subsequent return of the accessibility of the binding site to the cytoplasmic side (inward-facing, open NBD conformation)...
October 9, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29016107/continuous-elution-proteoform-identification-of-myelin-basic-protein-by-superficially-porous-reversed-phase-liquid-chromatography-and-fourier-transform-mass-spectrometry
#8
Daniel A Plymire, Casey Elizabeth Wing, Dana E Robinson, Steven Patrie
Myelin basic protein (MBP) plays an important structural and functional role in the neuronal myelin sheath. Translated MBP exhibits extreme microheterogeneity with numerous alternative splice variants (ASVs) and post- translational modifications (PTMs) reportedly tied to central nervous system maturation, myelin stability, and the pathobiology of various de- and dys-myelinating disorders. Conventional bioanalytical tools cannot efficiently examine ASV and PTM events simultaneously which limits understanding of the role of MBP microheterogeneity in human physiology and disease...
October 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28988864/museum-genomics-confirms-that-the-lord-howe-island-stick-insect-survived-extinction
#9
Alexander S Mikheyev, Andreas Zwick, Michael J L Magrath, Miguel L Grau, Lijun Qiu, You Ning Su, David Yeates
The Lord Howe Island stick insect, Dryococelus australis, was once common on the island but was driven to extinction after the arrival of ship rats in the early 20(th) century [1, 2]. It was thought to be extinct for decades, until a tiny population of similar-looking stick insects was discovered 20 km away, on the islet of Ball's Pyramid, in 2001 [2]. Individuals from this population are currently being reared in Australia and elsewhere in the world, with the eventual goal of recolonizing Lord Howe Island [3]...
October 4, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28985649/peripheral-blood-mononuclear-cell-immunophenotyping-in-fibrodysplasia-ossificans-progressiva-patients-evidence-for-monocyte-dnam1-up-regulation
#10
Genny Del Zotto, Francesca Antonini, Irma Azzari, Claudio Ortolani, Gino Tripodi, Francesca Giacopelli, Serena Cappato, Lorenzo Moretta, Roberto Ravazzolo, Renata Bocciardi
Background Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disorder caused by sporadic heterozygous mutations in ACVR1 gene which progressively leads to severe heterotopic ossification. FOP is characterized by episodic flare-ups triggered by different factors such as viral infections, tissue injuries, vaccinations or occurring without a recognizable cause. The sporadic course of the disease, the documented presence of an important inflammatory reaction in early lesions and the partial response to corticosteroids support the idea that the immune system, and in particular the innate component, may play a role in FOP pathogenesis...
October 6, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28984728/incidence-of-wrong-site-surgery-list-errors-for-a-2-year-period-in-a-single-national-health-service-board
#11
Alistair Geraghty, Lorna Ferguson, Craig McIlhenny, Paul Bowie
INTRODUCTION: Wrong-site/side surgical "never events" continue to cause considerable harm to patients, healthcare professionals, and organizations within the United Kingdom. Incidence has remained static despite the mandatory introduction of surgical checklists. Operating theater list errors have been identified as a regular contributor to these never events. The aims of the study were to identify and to learn from the incidence of wrong-site/side list errors in a single National Health Service board...
October 4, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28983173/huge-left-atrial-appendage-aneurysm-revealed-by-chronic-hiccups
#12
Iliyasse Asfalou, Meriem Boumaaz, Maha Raissouni, Mohammed Sabry, Aatif Benyass, El Mehdi Zbir
Left atrial appendage (LAA) aneurysm is an extremely rare anomaly. So far, less than one hundred cases only have been reported worldwide. Revelation modes are dominated by complications such as arrhythmias and thromboembolic events. We herein report a pediatric case of huge congenital LAA aneurysm with an original revelation mode that has never been described before in medical literature.
October 2017: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/28983075/cystic-fibrosis-swine-fail-to-secrete-airway-surface-liquid-in-response-to-inhalation-of-pathogens
#13
Xiaojie Luan, George Belev, Julian S Tam, Santosh Jagadeeshan, Noman Hassan, Paula Gioino, Nikolay Grishchenko, Yanyun Huang, James L Carmalt, Tanya Duke, Teela Jones, Bev Monson, Monique Burmester, Tomer Simovich, Orhan Yilmaz, Veronica A Campanucci, Terry E Machen, L Dean Chapman, Juan P Ianowski
Cystic fibrosis is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) channel, which can result in chronic lung disease. The sequence of events leading to lung disease is not fully understood but recent data show that the critical pathogenic event is the loss of the ability to clear bacteria due to abnormal airway surface liquid secretion (ASL). However, whether the inhalation of bacteria triggers ASL secretion and whether this is abnormal in cystic fibrosis has never been tested...
October 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/28982071/toxicological-effects-of-paracetamol-on-the-clam-ruditapes-philippinarum-exposure-vs-recovery
#14
Bruno Nunes, Joana Nunes, Amadeu M V M Soares, Etelvina Figueira, Rosa Freitas
Exposure of wild organisms to anthropogenic substances never follows a definite time-course and pulsed events can often determine biological responses to such chemicals, confounding the interpretation of toxicological data. This is the case of specific chemicals such as pharmaceutical drugs, which are commonly released by sewage systems into sensitive areas, including estuaries. The presence and amount of these chemicals in the wild can be modulated by events such as dilution due to heavy rain, floods, or by varying patterns of domestic water use (daily vs...
September 20, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28979239/severe-hypothyroidism-due-to-the-loss-of-therapeutic-efficacy-of-l-thyroxine-in-a-patient-with-esophageal-complication-associated-with-systemic-sclerosis
#15
Antonio Lobasso, Liliana Nappi, Letizia Barbieri, Carmela Peirce, Serena Ippolito, Debora Arpaia, Francesca Wanda Rossi, Amato de Paulis, Bernadette Biondi
BACKGROUND: Thyroid function abnormalities and thyroid autoantibodies have been frequently described in patients with systemic autoimmune diseases as systemic sclerosis (SSc). Serum TSH levels are higher in SSc patients with more severe skin diseases and a worse modified Rodnan skin score. Asymptomatic esophageal involvement due to SSc has never been described as a cause of severe hypothyroidism due to l-thyroxine (l-T4) malabsorption in patients with Hashimoto's thyroiditis (HT) and SSc...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28970215/metabolic-and-cardiovascular-benefits-of-hydroxychloroquine-in-patients-with-rheumatoid-arthritis-a-systematic-review-and-meta-analysis
#16
Claire Rempenault, Bernard Combe, Thomas Barnetche, Cécile Gaujoux-Viala, Cédric Lukas, Jacques Morel, Charlotte Hua
OBJECTIVE: Cardiovascular disease (CVD) is the leading cause of mortality in patients with rheumatoid arthritis (RA). Hydroxychloroquine (HCQ) has been shown to improve survival rates in other inflammatory diseases. We aimed to assess the available literature on the cardiovascular impact of HCQ in patients with RA. METHODS: We systematically searched for studies evaluating the effects of HCQ on cardiovascular outcomes of known risk factors for CVD in patients with RA...
September 25, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28967549/methotrexate-versus-cyclosporine-in-adults-with-moderate-to-severe-atopic-dermatitis-a-phase-iii-randomized-noninferiority-trial
#17
Catherine Goujon, Manuelle Viguier, Delphine Staumont-Sallé, Claire Bernier, Gérard Guillet, Morad Lahfa, Marie-Christine Ferrier Le Bouedec, Frédéric Cambazard, David Bottigioli, Sophie Grande, Karima Dahel, Frédéric Bérard, Muriel Rabilloud, Catherine Mercier, Jean-François Nicolas
BACKGROUND: Methotrexate is currently used to treat atopic dermatitis but has never been assessed versus cyclosporine in adults. OBJECTIVE: This study evaluated the efficacy and safety of methotrexate versus cyclosporine in patients with moderate-to-severe atopic dermatitis. METHODS: Patients were randomized to receive either oral methotrexate (15 mg/wk) or cyclosporine (2.5 mg/kg/d) for 8 weeks. The primary end point was a patient achieving 50% improvement in the SCORing Atopic Dermatitis index (SCORAD 50) at week 8...
September 26, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28966713/examining-the-impact-of-a-university-driven-exercise-programming-event-on-end-of-semester-stress-in-students
#18
Tessa L Koschel, John C Young, James W Navalta
Stress levels in university students peak during the final exam period. An inverse association exists between Physical Activity (PA) and poor mental health. UNLV has created Fitness4Finals (F4F), an event novel in its approach to academic stress reduction by incorporating both physical activity and mental relaxation. To our knowledge, a university-driven programming event aimed at reducing physiological and psychological stress among students approaching final exams had never been studied. Therefore, the aims of this research were to 1) examine the influence of F4F on physiological stress and perceived psychological stress (PPS) and 2) to examine the relationship between physiological stress and PPS...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28964441/cost-utility-of-partially-implantable-active-middle-ear-implants-for-sensorineural-hearing-loss-a-decision-analysis
#19
Melodi Kosaner Kliess, Martina Kluibenschaedl, Ruth Zoehrer, Bettina Schlick, Francesca Scandurra, Michael Urban
BACKGROUND: Partially implantable active middle ear implants (aMEIs) offer a solution for individuals who have mild to severe sensorineural hearing loss and an outer ear medical condition that precludes the use of hearing aids. When otherwise left untreated, individuals report a lower quality of life, which may further decrease with increasing disability. In the lack of cost-effectiveness studies and long-term data, there is a need for decision modeling. OBJECTIVE: To explore individual-level variance in resource utilization patterns following aMEI implantation...
September 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28962839/name-conditioning-in-event-related-brain-potentials
#20
Boris Kotchoubey, Yuri G Pavlov
Four experiments are reported in which two harmonic tones (CS+ and CS-) were paired with a participant's own name (SON) and different names (DN), respectively. A third tone was not paired with any other stimulus and served as a standard (frequent stimulus) in a three-stimuli oddball paradigm. The larger posterior positivity (P3) to SON than DN, found in previous studies, was replicated in all experiments. Conditioning of the P3 response was albeit observed in two similar experiments (1 and 3), but the obtained effects were weak and not identical in the two experiments...
September 28, 2017: Neurobiology of Learning and Memory
keyword
keyword
61213
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"