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Qualitative methods

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https://www.readbyqxmd.com/read/28922649/determination-of-74-new-psychoactive-substances-in-serum-using-automated-in-line-solid-phase-extraction-liquid-chromatography-tandem-mass-spectrometry
#1
Sabrina Lehmann, Tobias Kieliba, Justus Beike, Mario Thevis, Katja Mercer-Chalmers-Bender
A detailed description is given of the development and validation of a fully automated in-line solid-phase extraction-liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) method capable of detecting 90 central-stimulating new psychoactive substances (NPS) and 5 conventional amphetamine-type stimulants (amphetamine, 3,4-methylenedioxy-methamphetamine (MDMA), 3,4-methylenedioxy-amphetamine (MDA), 3,4-methylenedioxy-N-ethyl-amphetamine (MDEA), methamphetamine) in serum. The aim was to apply the validated method to forensic samples...
September 7, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28922538/women-s-experiences-of-more-than-one-termination-of-pregnancy-within-two-years-a-mixed-methods-study
#2
Carrie Purcell, Julie Riddell, Audrey Brown, Sharon Cameron, Catriona Melville, Gillian Flett, Yeshi Bhushan, Lisa McDaid
OBJECTIVE: To examine the experiences of women seeking more than one termination of pregnancy (TOP) within two years. DESIGN: Mixed methods study. SETTING: Six TOP services across Scotland. SAMPLE: Women presenting for TOP between July and December 2015. METHODS: Descriptive and inferential analysis of quantitative survey data, thematic analysis of qualitative interview data and integrative analysis...
September 18, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28922130/haze-removal-using-radial-basis-function-networks-for-visibility-restoration-applications
#3
Bo-Hao Chen, Shih-Chia Huang, Chian-Ying Li, Sy-Yen Kuo
Restoration of visibility in hazy images is the first relevant step of information analysis in many outdoor computer vision applications. To this aim, the restored image must feature clear visibility with sufficient brightness and visible edges, while avoiding the production of noticeable artifacts. In this paper, we propose a haze removal approach based on the radial basis function (RBF) through artificial neural networks dedicated to effectively removing haze formation while retaining not only the visible edges but also the brightness of restored images...
September 15, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28922074/breast-cancer-survivors-perceptions-of-participating-in-a-supervised-exercise-intervention-an-exploratory-review-of-the-literature
#4
Leanne Livsey, Kiara Lewis
BACKGROUND: Despite the reported beneficial effects of physical activity (PA) during and after cancer diagnosis, current research data suggest that the percentages of breast cancer survivors who adhere to PA recommendations are low. The aim of the present systematic, critical review was to identify, analyze and provide a summary of qualitative literature findings, which have explored breast cancer survivors' experiences of participating in an exercise/PA intervention after cancer treatment...
September 18, 2017: Women & Health
https://www.readbyqxmd.com/read/28922038/a-mixed-methods-study-of-emotional-exhaustion-energizing-and-depleting-work-within-an-innovative-healthcare-team
#5
Cindy L Cain, Caitlin Taborda-Whitt, Monica Frazer, Sandra Schellinger, Katie M White, Jason Kaasovic, Brenda Nelson, Allison Chant
This mixed methods study documents emotional exhaustion experiences among care team members during the development of an innovative team approach for caring for adults with serious illness. A mixed methods study design was employed to examine depleting work experiences that may produce emotional exhaustion, and energizing aspects of the work that may increase meaningfulness of work, thus reducing emotional exhaustion. The population studied included team members involved in care for adults with serious illness (n = 18)...
September 18, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28922030/rapid-detection-and-classification-of-salmonella-enterica-shedding-in-feedlot-cattle-utilizing-the-roka-bioscience-atlas-salmonella-detection-assay-for-the-analysis-of-rectoanal-mucosal-swabs
#6
W Evan Chaney, Getahun E Agga, Scott V Nguyen, Terrance M Arthur, Joseph M Bosilevac, Erin Dreyling, Anantharama Rishi, Dayna Brichta-Harhay
With an increasing focus on preharvest food safety, rapid methods are required for the detection and quantification of foodborne pathogens such as Salmonella enterica in beef cattle. We validated the Atlas Salmonella Detection Assay (SEN), a nucleic acid amplification technology that targets Salmonella rRNA, for the qualitative detection of S. enterica with sample enrichment using immunomagnetic separation as a reference test, and we further evaluated its accuracy to predict pathogen load using SEN signal-to-cutoff (SCO) values from unenriched samples to classify animals as high or nonhigh shedders...
September 18, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28921881/use-of-a-radial-projection-to-reduce-the-statistical-uncertainty-of-spot-lateral-profiles-generated-by-monte-carlo-simulation
#7
Xiaoning Ding, Wei Liu, Jiajian Shen, Aman Anand, Joshua B Stoker, Yanle Hu, Martin Bues
Monte Carlo (MC) simulation has been used to generate commissioning data for the beam modeling of treatment planning system (TPS). We have developed a method called radial projection (RP) for postprocessing of MC-simulation-generated data. We used the RP method to reduce the statistical uncertainty of the lateral profile of proton pencil beams with axial symmetry. The RP method takes advantage of the axial symmetry of dose distribution to use the mean value of multiple independent scores as the representative score...
September 18, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28921580/integrating-prior-information-into-microwave-tomography-part-1-impact-of-detail-on-image-quality
#8
Douglas Kurrant, Anastasia Baran, Joe LoVetri, Elise Fear
PURPOSE: The authors investigate the impact that incremental increases in the level of detail of patient-specific prior information have on image quality and the convergence behavior of an inversion algorithm in the context of near-field microwave breast imaging. A methodology is presented that uses image quality measures to characterize the ability of the algorithm to reconstruct both internal structures and lesions embedded in fibroglandular tissue. The approach permits key aspects that impact the quality of reconstruction of these structures to be identified and quantified...
September 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28921574/ideology-and-resistance-in-young-people-s-experiences-of-health-under-the-imperative-of-enjoyment
#9
Kathrine Vitus
This article explores upper secondary school students' understandings and experiences of health in Denmark, where public health promotions appeal to pleasure. Health promotion thereby taps into capitalist society's 'imperative of enjoyment', which reproduces ideological fantasies about the fulfilment of desires through the consumption of health. Based on qualitative empirical material produced through participatory and visual methods during fieldwork conducted in 2012, the analysis shows that relations between healthiness and pleasure are conflated and paradoxical: the students try to fit into society not only by being healthy, but also by enjoying healthiness; but if they fail pleasure, they fail healthiness and experience a loss of individual social value...
September 17, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/28921173/maximizing-safe-resections-the-roles-of-5-aminolevulinic-acid-and-intraoperative-mr-imaging-in-glioma-surgery-review-of-the-literature
#10
REVIEW
Eric Suero Molina, S Schipmann, W Stummer
Malignant glioma surgery involves the challenge of preserving the neurological status of patients harboring these lesions while pursuing a maximal tumor resection, which is correlated with overall and progression-free survival. Presently, several tools exist for assisting neurosurgeons in visualizing malignant tissue. Fluorescence-guided surgery (FGS) with 5-aminolevulinic acid (5-ALA) has increasingly been used during the last decade for identifying malignant glioma. Intraoperative magnetic resonance imaging (iMRI), first introduced in the mid-1990s, is being evaluated as a further tool to maximize the extent of resection...
September 18, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28920966/-prevention-of-cardiovascular-diseases-prophylactic-program-in-a-selected-enterprise
#11
Jadwiga Siedlecka, Elżbieta Gadzicka, Agata Szyjkowska, Patryk Siedlecki, Wiesław Szymczak, Teresa Makowiec-Dąbrowska, Alicja Bortkiewicz
BACKGROUND: In Poland cardiovascular diseases (CVD), classified as work-related diseases, are responsible for 25% of disability and cause 50% of all deaths, including 26.9% of deaths in people aged under 65 years. The aim of the study was to analyze employee expectations regarding CVD- oriented prophylactic activities in the selected enterprise. MATERIAL AND METHODS: A questionnaire, developed for this study, consists of: socio-demographic data, job characteristics, occupational factors, and questions about the respondents' expectations concerning the prevention program...
September 18, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28920680/a-restricted-open-configuration-interaction-with-singles-method-to-calculate-valence-to-core-resonant-x-ray-emission-spectra-a-case-study
#12
Dimitrios Maganas, Serena DeBeer, Frank Neese
In this work, a new protocol for the calculation of valence-to-core resonant X-ray emission (VtC RXES) spectra is introduced. The approach is based on the previously developed restricted open configuration interaction with singles (ROCIS) method and its parametrized version, based on a ground-state Kohn-Sham determinant (DFT/ROCIS) method. The ROCIS approach has the following features: (1) In the first step approximation, many-particle eigenstates are calculated in which the total spin is retained as a good quantum number...
September 18, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28919839/ground-up-top-down-a-mixed-method-action-research-study-aimed-at-normalising-research-in-practice-for-nurses-and-midwives
#13
Vicki Parker, Gena Lieschke, Michelle Giles
BACKGROUND: Improving health, patient and system outcomes through a practice-based research agenda requires infrastructural supports, leadership and capacity building approaches, at both the individual and organisational levels. Embedding research as normal nursing and midwifery practice requires a flexible approach that is responsive to the diverse clinical contexts within which care is delivered and the variable research skills and interest of clinicians. This paper reports the study protocol for research being undertaken in a Local Health District (LHD) in New South Wales (NSW) Australia...
2017: BMC Nursing
https://www.readbyqxmd.com/read/28919163/multiplex-pcr-and-ngs-based-identification-of-mrna-splicing-variants-analysis-of-brca1-splicing-pattern-as-a-model
#14
Jan Hojny, Petra Zemankova, Filip Lhota, Jan Sevcik, Viktor Stranecky, Hana Hartmannova, Katerina Hodanova, Ondrej Mestak, David Pavlista, Marketa Janatova, Jana Soukupova, Michal Vocka, Zdenek Kleibl, Petra Kleiblova
Alternative pre-mRNA splicing increases transcriptome plasticity by forming naturally-occurring alternative splicing variants (ASVs). Alterations of splicing processes, caused by DNA mutations, result in aberrant splicing and the formation of aberrant mRNA isoforms. Analyses of hereditary cancer predisposition genes reveal many DNA variants with unknown clinical significance (VUS) that potentially affect pre-mRNA splicing. Therefore, a comprehensive description of ASVs is an essential prerequisite for the interpretation of germline VUS in high-risk individuals...
September 14, 2017: Gene
https://www.readbyqxmd.com/read/28918570/mathematical-description-of-drug-target-interactions-application-to-biologics-that-bind-to-targets-with-two-binding-sites
#15
Leonid Gibiansky, Ekaterina Gibiansky
The emerging discipline of mathematical pharmacology occupies the space between advanced pharmacometrics and systems biology. A characteristic feature of the approach is application of advance mathematical methods to study the behavior of biological systems as described by mathematical (most often differential) equations. One of the early application of mathematical pharmacology (that was not called this name at the time) was formulation and investigation of the target-mediated drug disposition (TMDD) model and its approximations...
September 16, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/28918540/a-mixed-method-assessment-of-a-pilot-peer-advocate-intervention-for-rural-gender-and-sexual-minorities
#16
Cathleen E Willging, Audrey Harkness, Tania Israel, David Ley, Patricia S Hokanson, Catherine DeMaria, Aaron Joplin, Verida Smiley
Mental health disparities affect lesbian, gay, bisexual, transgender, and queer (LGBTQ) people in rural America. There are few empirically-based mental health interventions for this population. This exploratory study uses a mixed-method approach to assess implementation issues related to the feasibility, acceptability, appropriateness, and preliminary impacts of a novel peer-based intervention designed to enhance support and treatment engagement among rural LGBTQ people with mental distress and/or addiction issues...
September 16, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28918472/a-reliable-protocol-for-colorimetric-determination-of-iron-oxide-nanoparticle-uptake-by-cells
#17
Daiana K Deda, Roberta M Cardoso, Mayara K Uchiyama, Christiane Pavani, Sergio H Toma, Mauricio S Baptista, Koiti Araki
Size, shape, and surface properties of superparamagnetic iron oxide nanoparticles (SPIONs) can influence their interaction with biological systems, particularly the incorporation by tumor cells and consequently the biological activity and efficiency in biomedical applications. Several strategies have been used to evaluate cellular uptake of SPIONs. While qualitative methods are generally based on microscopy techniques, quantitative assays are carried out by techniques such as inductively coupled plasma-mass spectrometry and flow cytometry...
September 16, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28918371/willems-method-of-dental-age-estimation-in-children-a-systematic-review-and-meta-analysis
#18
REVIEW
J S Sehrawat, Monika Singh
BACKGROUND: Age estimation from dental developmental stages is considered comparatively more accurate, reliable and precise than other methods used in forensic sciences. Willems method is the revised version of Demirjian method, based on modified dental maturity scores to estimate age of children in years for both the sexes. AIMS: To test the applicability and accuracy level of Willems method of dental age estimation in diverse population samples by quantifying the variations between the chronological and estimated ages of an individual...
August 25, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28918325/a-novel-lc-ms-ms-method-for-the-quantitative-measurement-of-the-acetate-content-in-pharmaceutical-peptides
#19
Rani J Qasem, Ibrahim K Farh, Mohammed A Al Essa
Most pharmaceutical peptides are supplied as acetate salts and the relative amount of acetate to peptide in the final product is one quality criterion required by regulatory agencies to approve the product for clinical use. The objective of the present study was to develop a validated LC-MS/MS method that allows the quantitative determination of the acetate content in pharmaceutical peptide preparations and simultaneous monitoring and collection of qualitative and quantitative information on the peptide during manufacture and in the final product...
September 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28918300/dynamical-properties-of-lfps-from-mice-with-unilateral-injection-of-tent
#20
Eleonora Vannini, Matteo Caleo, Santi Chillemi, Angelo Di Garbo
Local field potential (LFP) recordings were performed from the visual cortex (V1) of a focal epilepsy mouse model. Epilepsy was induced by a unilateral injection of the synaptic blocker tetanus neurotoxin (TeNT). LFP signals were simultaneously recorded from V1 of both hemispheres of each animal under acute and chronic conditions (i.e. during and after the period of TeNT action). All data were analysed by using nonlinear time series methods. Suitable values of the lag time and embedding dimension for phase space reconstruction were estimated by employing well-known methods...
September 13, 2017: Bio Systems
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