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https://www.readbyqxmd.com/read/29458074/subthalamic-nucleus-stimulation-dopaminergic-treatment-and-impulsivity-in-parkinson-s-disease
#1
Frédérique Fluchère, Borís Burle, Franck Vidal, Wery van den Wildenberg, Tatiana Witjas, Alexandre Eusebio, Jean-Philippe Azulay, Thierry Hasbroucq
BACKGROUND: Deep brain stimulation of the subthalamic nucleus (STN DBS) is known to increase response speed and lower response accuracy in Parkinson's disease (PD) patients. It has been proposed that this speed-accuracy tradeoff is due to enhanced sensitivity of the motor system to sensory information. An alternative possibility is that this effect is due to weakened suppressive processes. The two alternative interpretations can be tested by analyzing the electromyographic activity (EMG) of the response agonists when the patients perform conflict reaction time tasks...
February 16, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29457493/the-impact-of-vitamin-d-supplementation-on-attention-deficit-hyperactivity-disorder-in-children
#2
Hatem Hamed Elshorbagy, Naglaa Fathy Barseem, Waleed Elsayed Abdelghani, Hany Abdelaziz Ibrahim Suliman, Ashraf Hamed Al-Shokary, Sameh Elsayed Abdulsamea, Akram Elshafey Elsadek, Yehia Hamed Abdel Maksoud, Dalia Mohamed Abd El-Hassib Nour El Din
BACKGROUND: The role of nutrients and dietary factors in attention-deficit hyperactivity disorder (ADHD) remains unclear. OBJECTIVES: The primary objective was to evaluate the serum vitamin D level in children with a diagnosis of ADHD. The secondary objective was to detect the effect of vitamin D supplementation on cognitive function in those with vitamin D deficiency. METHODS: A total of 50 children with ADHD and 40 healthy controls were included in the study...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29457317/effects-of-alcohol-intoxication-on-self-reported-drinking-patterns-expectancies-motives-and-personality-a-randomized-controlled-experimental-study
#3
Sören Kuitunen-Paul, Elisabeth Obst, Ruth Schmidt, Christian Sommer, Paula T Kuitunen, Hans-Ulrich Wittchen, Ulrich S Zimmermann
Alcohol intoxication may affect self-reports of alcohol use and related constructs, such as impulsivity and dependence symptoms. Improved knowledge about potential systematic reporting biases induced by alcohol, e.g. through disinhibition, may be relevant for the assessment of intoxicated individuals both in clinical routine and research. We therefore randomly assigned 54 socially drinking males aged 18 to 19 without lifetime diagnosis of DSM-IV alcohol dependence to one of two experimental arms: either placebo infusion at day 1 and alcohol infusion at day 2, or vice versa...
February 19, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29457246/randomized-controlled-prospective-clinical-trial-of-autologous-greater-omentum-free-graft-versus-autogenous-cancellous-bone-graft-in-radial-and-ulnar-fractures-in-miniature-breed-dogs
#4
Jennifer J Ree, Wendy I Baltzer, Sarah Nemanic
OBJECTIVE: To determine the rate of radiographic healing, complications, vascularization, and bone density after repair of radial and ulnar fractures in dogs <6 kg that were treated with an autogenous cancellous bone graft (BG) or free autologous omentum graft (OG). STUDY DESIGN: Prospective, randomized, controlled clinical trial with owners/radiologists blinded to treatment. ANIMALS: 25 dogs with naturally occurring traumatic radial/ulnar fractures...
February 19, 2018: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29455442/in-search-of-executive-impairment-in-pathological-gambling-a-neuropsychological-study-on-non-treatment-seeking-gamblers
#5
Alexandros Kapsomenakis, Panagiotis G Simos, Georgios Konstantakopoulos, Dimitrios S Kasselimis
Pathological gambling is characterized by a persisting maladaptive and recurrent behavior with severe social and psychological consequences. There is evidence of strong comorbidity with psychiatric manifestations as well as cognitive mainly involving executive functions. This study aimed to investigate impairment in executive functions and working memory, and personality traits in a sample of Greek gamblers. Twenty-four men involved in various gambling activities were recruited from ecological settings as probable pathological gamblers...
February 17, 2018: Journal of Gambling Studies
https://www.readbyqxmd.com/read/29454934/time-scale-properties-of-task-and-resting-state-functional-connectivity-detrended-partial-cross-correlation-analysis
#6
Jaime S Ide, Chiang-Shan R Li
Functional connectivity analysis is an essential tool for understanding brain function. Previous studies showed that brain regions are functionally connected through low-frequency signals both within the default mode network (DMN) and task networks. However, no studies have directly compared the time scale (frequency) properties of network connectivity during task versus rest, or examined how they relate to task performance. Here, using fMRI data collected from sixty-eight subjects at rest and during a stop signal task, we addressed this issue with a novel functional connectivity measure based on detrended partial cross-correlation analysis (DPCCA)...
February 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/29454164/self-reported-inhibition-predicts-history-of-suicide-attempts-in-bipolar-disorder-and-major-depression
#7
André Ponsoni, Laura Damiani Branco, Charles Cotrena, Flávio Milman Shansis, Rodrigo Grassi-Oliveira, Rochele Paz Fonseca
BACKGROUND: Studies have reliably identified an association between suicide attempts and executive functions such as decision making (DM) and inhibitory control (IC) in patients with mood disorders. As such, the present study aimed to investigate the association between inhibition, DM, impulsivity and the history of suicide attempts in individuals with bipolar (BD) or major depressive disorder (MDD), identifying which assessment instruments may be most strongly associated with suicide in clinical samples...
February 14, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29453444/positive-regulation-of-raphe-serotonin-neurons-by-serotonin-2b-receptors
#8
Arnauld Belmer, Emily Quentin, Silvina L Diaz, Bruno P Guiard, Sebastian P Fernandez, Stéphane Doly, Sophie M Banas, Pothitos M Pitychoutis, Imane Moutkine, Aude Muzerelle, Anna Tchenio, Anne Roumier, Manuel Mameli, Luc Maroteaux
Serotonin is a neurotransmitter involved in many psychiatric diseases. In humans, a lack of 5-HT 2B receptors is associated with serotonin-dependent phenotypes, including impulsivity and suicidality. A lack of 5-HT 2B receptors in mice eliminates the effects of molecules that directly target serotonergic neurons including amphetamine derivative serotonin releasers, and selective serotonin reuptake inhibitor antidepressants. In this work, we tested the hypothesis that 5-HT 2B receptors directly and positively regulate raphe serotonin neuron activity...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29453304/protocol-investigating-the-clinical-utility-of-an-objective-measure-of-attention-impulsivity-and-activity-qbtest-for-optimising-medication-management-in-children-and-young-people-with-adhd-qbtest-utility-for-optimising-treatment-in-adhd-quota-a-feasibility
#9
Charlotte L Hall, Marilyn James, Sue Brown, Jennifer L Martin, Nikki Brown, Kim Selby, Julie Clarke, Hena Vijayan, Boliang Guo, Kapil Sayal, Chris Hollis, Madeleine J Groom
INTRODUCTION: Attention-deficit hyperactivity disorder (ADHD) is characterised by symptoms of inattention, hyperactivity and impulsivity. To improve outcomes, the National Institute for Health and Care Excellence ADHD guidelines recommend regular monitoring of symptoms when children commence medication. However, research suggests that routine monitoring rarely happens, and clinicians often rely on subjective information such as reports from parents and teachers to ascertain improvement...
February 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29453244/white-matter-change-with-apathy-and-impulsivity-in-frontotemporal-lobar-degeneration-syndromes
#10
Claire J Lansdall, Ian T S Coyle-Gilchrist, P Simon Jones, Patricia Vázquez Rodríguez, Alicia Wilcox, Eileen Wehmann, Katrina M Dick, Trevor W Robbins, James B Rowe
OBJECTIVE: To identify the white matter correlates of apathy and impulsivity in the major syndromes associated with frontotemporal lobar degeneration, using diffusion-weighted imaging and data from the PiPPIN (Pick's Disease and Progressive Supranuclear Palsy: Prevalence and Incidence) study. We included behavioral and language variants of frontotemporal dementia, corticobasal syndrome, and progressive supranuclear palsy. METHODS: Seventy patients and 30 controls underwent diffusion tensor imaging at 3-tesla after detailed assessment of apathy and impulsivity...
February 16, 2018: Neurology
https://www.readbyqxmd.com/read/29449824/reduced-self-control-after-3-months-of-imprisonment-a-pilot-study
#11
Jesse Meijers, Joke M Harte, Gerben Meynen, Pim Cuijpers, Erik J A Scherder
Background: Prison can be characterized as an impoverished environment encouraging a sedentary lifestyle with limited autonomy and social interaction, which may negatively affect self-control and executive function. Here, we aim to study the effects of imprisonment on self-control and executive functions, and we report the change in neuropsychological outcome after 3 months of imprisonment. Materials and Methods: Participants were 37 male inmates in a remand prison in Amsterdam, Netherlands, who completed six tests of a computerized neuropsychological test battery (the Cambridge Automated Neuropsychological Test Battery) in the first week of arrival...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29448234/gene-expression-changes-in-the-ventral-hippocampus-and-medial-prefrontal-cortex-of-adolescent-alcohol-preferring-p-rats-following-binge-like-alcohol-drinking
#12
Jeanette N McClintick, William J McBride, Richard L Bell, Zheng-Ming Ding, Yunlong Liu, Xiaoling Xuei, Howard J Edenberg
Binge drinking of alcohol during adolescence is a serious public health concern with long-term consequences, including decreased hippocampal and prefrontal cortex volume and deficits in memory. We used RNA sequencing to assess the effects of adolescent binge drinking on gene expression in these regions. Male adolescent alcohol-preferring (P) rats were exposed to repeated binge drinking (three 1-h sessions/day during the dark/cycle, 5 days/week for 3 weeks starting at 28 days of age; ethanol intakes of 2.5-3 g/kg/session)...
September 14, 2017: Alcohol
https://www.readbyqxmd.com/read/29447931/impulsive-mechanisms-influencing-relapse-in-alcohol-drinking
#13
Hugo E Reyes-Huerta, Cristiano Dos Santos, Kalina Martínez
Impulsivity has been related to different features of addictive behaviors. Growing data, generated in separated lines of research, suggest that different processes underlying impulsivity are associated to relapse in alcohol drinking. Considering the evidence, relapse can be understood as an impulsive choice or as an impulsive action. In the first case, the return to drinking behavior is a consequence of insensitive to delayed consequence, that is, to the discounting of delayed rewards. In the second case, relapse is a consequence of failures to inhibit prepotent responses...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29445867/sustained-effects-of-neurofeedback-in-adhd-a-systematic-review-and-meta-analysis
#14
REVIEW
Jessica Van Doren, Martijn Arns, Hartmut Heinrich, Madelon A Vollebregt, Ute Strehl, Sandra K Loo
Neurofeedback (NF) has gained increasing interest in the treatment of attention-deficit/hyperactivity disorder (ADHD). Given learning principles underlie NF, lasting clinical treatment effects may be expected. This systematic review and meta-analysis addresses the sustainability of neurofeedback and control treatment effects by considering randomized controlled studies that conducted follow-up (FU; 2-12 months) assessments among children with ADHD. PubMed and Scopus databases were searched through November 2017...
February 14, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29445770/subthalamic-neural-activity-patterns-anticipate-economic-risk-decisions-in-gambling
#15
A Mazzoni, M Rosa, J Carpaneto, L M Romito, A Priori, S Micera
Economic decision-making is disrupted in individuals with gambling disorder, an addictive behavior observed in Parkinson's disease (PD) patients receiving dopaminergic therapy. The subthalamic nucleus (STN) is involved in the inhibition of impulsive behaviors; however, its role in impulse control disorders and addiction is still unclear. Here, we recorded STN local field potentials (LFPs) in PD patients with and without gambling disorder during an economic decision-making task. Reaction times analysis showed that for all patients, the decision whether to risk preceded task onset...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29444387/the-structure-of-the-apo-camp-binding-domain-of-hcn4-a-stepping-stone-towards-understanding-the-camp-dependent-modulation-of-the-hyperpolarization-activated-cyclic-nucleotide-gated-hcn-ion-channels
#16
REVIEW
Madoka Akimoto, Bryan VanSchouwen, Giuseppe Melacini
The hyperpolarization-activated cyclic-nucleotide-gated (HCN) ion channels control nerve impulse transmission and cardiac pacemaker activity. The modulation by cAMP is critical for the regulatory function of HCN in both neurons and cardiomyocytes, but the underlying mechanism is not fully understood. Here, we show how the structure of the apo cAMP-binding domain of the HCN4 isoform has contributed to a model for the cAMP-dependent modulation of the HCN ion-channel. This model recapitulates the structural and dynamical changes that occur along the thermodynamic cycle arising from the coupling of cAMP-binding and HCN self-association equilibria...
February 14, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29443739/effects-of-exercise-on-secretion-transport-inflammation-and-quality-of-life-in-patients-with-noncystic-fibrosis-bronchiectasis-protocol-for-a-randomized-controlled-trial
#17
Daniele Oliveira Dos Santos, Hugo Celso Dutra de Souza, José Antônio Baddini-Martinez, Ercy Mara Cipulo Ramos, Ada Clarice Gastaldi
BACKGROUND: Bronchiectasis is characterized by pathological and irreversible bronchial dilatation caused by the inefficient mucus and microorganism clearance and progression of inflammatory processes. The most frequent characteristic is the increase in bronchial mucus production resulting in slower transport and damage to the mucociliary transport. AIMS: To evaluate the effects of exercise on mucus transport, inflammation, and resistance of the respiratory and autonomic nervous systems and subsequent effects on quality of life in patients with bronchiectasis who are enrolled in a pulmonary rehabilitation program...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29442271/exploring-variability-in-basal-ganglia-connectivity-with-functional-mri-in-healthy-aging
#18
Ludovica Griffanti, Philipp Stratmann, Michal Rolinski, Nicola Filippini, Enikő Zsoldos, Abda Mahmood, Giovanna Zamboni, Gwenaëlle Douaud, Johannes C Klein, Mika Kivimäki, Archana Singh-Manoux, Michele T Hu, Klaus P Ebmeier, Clare E Mackay
Changes in functional connectivity (FC) measured using resting state fMRI within the basal ganglia network (BGN) have been observed in pathologies with altered neurotransmitter systems and conditions involving motor control and dopaminergic processes. However, less is known about non-disease factors affecting FC in the BGN. The aim of this study was to examine associations of FC within the BGN with dopaminergic processes in healthy older adults. We explored the relationship between FC in the BGN and variables related to demographics, impulsive behavior, self-paced tasks, mood, and motor correlates in 486 participants in the Whitehall-II imaging sub-study using both region-of-interest- and voxel-based approaches...
February 13, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29440116/improving-interpretation-of-cardiac-phenotypes-and-enhancing-discovery-with-expanded-knowledge-in-the-gene-ontology
#19
Ruth C Lovering, Paola Roncaglia, Douglas G Howe, Stanley J F Laulederkind, Varsha K Khodiyar, Tanya Z Berardini, Susan Tweedie, Rebecca E Foulger, David Osumi-Sutherland, Nancy H Campbell, Rachael P Huntley, Philippa J Talmud, Judith A Blake, Ross Breckenridge, Paul R Riley, Pier D Lambiase, Perry M Elliott, Lucie Clapp, Andrew Tinker, David P Hill
BACKGROUND: A systems biology approach to cardiac physiology requires a comprehensive representation of how coordinated processes operate in the heart, as well as the ability to interpret relevant transcriptomic and proteomic experiments. The Gene Ontology (GO) Consortium provides structured, controlled vocabularies of biological terms that can be used to summarize and analyze functional knowledge for gene products. METHODS AND RESULTS: In this study, we created a computational resource to facilitate genetic studies of cardiac physiology by integrating literature curation with attention to an improved and expanded ontological representation of heart processes in the Gene Ontology...
February 2018: Circ Genom Precis Med
https://www.readbyqxmd.com/read/29438818/small-and-large-airway-reactions-to-osmotic-stimuli-in-asthma-and-chronic-idiopathic-cough
#20
Ewa-Lena Johansson, Ewa Ternesten-Hasséus, Per Gustafsson, Teet Pullerits, Monica Arvidsson, Eva Millqvist
BACKGROUND: Chronic cough is a common symptom and related to several pulmonary, airway and heart diseases. When all likely medical explanations for the coughing are excluded, there remains a large group of patients with chronic coughing, which is mostly a cough reflex easily triggered by environmental irritants and noxious stimuli. The main aim of this study was to improve the diagnostic ability to differentiate chronic idiopathic cough (CIC) from asthma. METHODS: Twenty-three patients with CIC, 16 patients with mild asthma and 21 control participants were included...
February 10, 2018: Pulmonary Pharmacology & Therapeutics
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