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Juan Wu, Jie Yang, Jie Zhao, Jingrong Wu, Xuan Zhang, W Keung Leung, Weibin Sun
AIM: We report a rare case of periodontal Ehlers-Danlos syndrome (pEDS) associated with severe periodontitis and tooth loss in a Chinese family. MATERIAL AND METHODS: The proband complained of gingival bleeding and mobility, which were also reported in his mother, and maternal uncle and his maternal grandmother and great-grandfather in the past. All family members underwent oral, physical, dermatological, and genetic examinations. RESULTS: Oral manifestation of family members affected with pEDS presented severe periodontitis with multiple or total tooth loss...
July 19, 2018: Journal of Clinical Periodontology
S M Gallitano, D S Berson
Acne vulgaris is one of the most common dermatologic complaints. Although dermatologists are skilled at treating acne, invisible psychological scars can be left by the disease. We review 13 articles that examined the effect of acne vulgaris on patients' self-esteem. Overall, these studies demonstrated that acne has a negative effect on self-esteem among patients of all age groups. These effects most strongly affect women and those with severe acne (both subjectively and objectively). Despite the impact on self-esteem, only a minority of patients seek medical treatment, and even fewer seek treatment from a dermatologist...
March 2018: International Journal of Women's Dermatology
Richard D Sontheimer
James Neil Gilliam, MD, was an American academic physician who was trained in internal medicine, dermatology, dermatopathology and rheumatology. This "quadruple-threat" profile of postgraduate medical training provided him with a rather unique perspective on genetically-complex, environmentally-impacted human autoimmune disorders such as lupus erythematosus (LE). Both the skin and vital internal organs can be damaged by LE autoimmunity. And, LE is clinically-expressed quite variably from one individual to another making prognosis difficult...
June 2018: Annals of Translational Medicine
Krishna Arudra, Ravi Patel, Michael Tetzlaff, Sharon Hymes, Vivek Subbiah, Funda Meric-Bernstam, Carlos Torres-Cabala, Phyu P Aung, Priyadharsini Nagarajan, Adi Diab, Victor G Prieto, Kelly Nelson, Jonathan L Curry
Small-molecule inhibitors (nibs) have revolutionized cancer therapy with the emergence of clinically efficacious treatment for advanced-stage malignancies. Fibroblast growth factor receptor (FGFR) inhibitors have shown therapeutic efficacy in malignancies with molecular-genetic alterations in the FGFR/FGF pathway. In a phase 1 clinical trial, erdafitinib, a pan FGFR inhibitor, was well tolerated with a manageable toxicity profile. Hyperphosphatemia was a frequent adverse event in patients treated with erdafitinib; however, no serious complications were observed with this therapy...
July 18, 2018: Journal of Cutaneous Pathology
Corey DeWitt, Todd Holmes
BACKGROUND: Island pedicle flaps (IPFs) are a frequently used reconstructive option in dermatologic surgery. With variations in its execution, the flap can be used for an assortment of facial defects. OBJECTIVE: To describe the execution of a flipped IPF for the reconstruction of medium to large preauricular wounds after Mohs micrographic surgery. MATERIALS AND METHODS: An analysis of the flipped IPF reconstruction of 12 preauricular defects is presented...
July 16, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Imre Lorinc Szabo, Anna Kenyeres, Andrea Szegedi, Attila Gabor Szollosi
The skin is often introduced as the largest organ of the human body which - being uniquely exposed to external stress - faces several types of challenges, from physical, chemical, biological, and immunological origin. Therefore, the skin is also a site where inflammation, oxidative stress and cellular damage occurs regularly. Heme oxygenase (HO), primarily functioning in the catabolism of heme, is a very important cytoprotective enzyme that has antioxidant, anti-inflammatory and anti-apoptotic properties. Given the need for an enzyme with such a combination of attributes in the skin, it is not surprising that HO is involved in physiological processes as well as pathological conditions of the skin...
July 17, 2018: Current Pharmaceutical Design
Caterina Ferreli, Margherita Caravano, Giuseppe Fumo, Franco Rongioletti
AIM AND METHODS: Digital mucous cysts (DMCs) are benign, translucent, fluid-filled asymptomatic, slow-growing, dome-shaped nodules overlying a joint or tendon sheath on the distal dorsal side of the fingers or, more rarely, on the toes. They are degenerative in nature and are often associated with interphalangeal joint arthritis. Although DMCs are usually solitary, multiple cysts have been observed to develop simultaneously. They can sometimes be painful, confer a reduction in motility, and cause weakness and deformity in the nails...
July 18, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Piet E J van Erp, Malou Peppelman, Denise Falcone
In this review we aim to give a concise and selective overview of noninvasive biophysical analysis techniques for skin barrier analysis (transepidermal water loss, electrical methods, confocal Raman microspectroscopy, sebumeter, reflectance spectrophotometry, tristimulus colorimetry, diffuse reflectance spectroscopy and reflectance confocal microscopy), including advantages and limitations. Rather than giving an exhaustive description of the many techniques currently available, we show the usefulness of a representative selection of techniques in the functional and morphological evaluation of the skin barrier...
July 17, 2018: Experimental Dermatology
Gandhiv Kafle, Indira Bhattarai Sharma, Mohan Siwakoti, Arjun Kumar Shrestha
Neopicrorhiza scrophulariiflora (Pennell) D. Y. Hong of Scrophulariaceae family (hereinafter referred to as Neopicrorhiza ) has medicinally important rhizomes with high levels of trade. What factors drive demand for Neopicrorhiza in Central Himalaya is unknown. In this context, a nationwide comprehensive survey was conducted from September 2016 to March 2017 to assess demand, end-uses, and conservation of dry Neopicrorhiza rhizomes in Nepal. A total of 2313 herbal products were surveyed for Neopicrorhiza as an ingredient in 38 retailer shops...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
David G Li, Fan Di Xia, Jasmine Rana, Grace J Young, Forootan Alizadeh, Cara Joyce, Shinjita Das, Arash Mostaghimi
Variations in treatment modalities for skin growths contribute substantially to overall healthcare spending within dermatology. However, little is known regarding factors impacting patient decision-making when choosing a treatment modality. In this survey-based, cross-sectional study (n = 375, 81.9% response rate), we asked patients to rate the importance of different treatment parameters for a nonfacial skin growth, further classified into five domains: efficacy, appearance, financial impact, visit duration, and productivity...
2018: Dermatology Research and Practice
Adriana T Lopez, Larisa Geskin
Immunotherapy has emerged as a highly effective treatment for numerous cancers. Use of checkpoint inhibitors against various molecules including programmed cell death protein-1 (PD-1), programmed death ligand-1 (PD-L1), and cytotoxic T-lymphocyte-associated protein-4 have become widespread in clinical practice. Compared with conventional chemotherapy, immunotherapy is associated with a unique set of immune reactions known collectively as immune-related adverse events (irAEs). Of known irAEs, cutaneous toxicity is among the most frequently observed in patients treated with immunotherapy...
July 17, 2018: Oncologist
Krishna Yadav, Deependra Singh, Manju Rawat Singh
Psoriasis is defined as a long-lasting multifactorial inflammatory autoimmune skin condition precisely characterized by delimited, erythematic papules with adherent shiny scales. The conditions are led by hyperproliferative responses of epidermis due to hyperactivation and immature keratinocytes production. The psoriatic skin consists of the thickened epidermal layer, in concurrence with inflammatory exudates in the dermis mainly of dendritic cells, neutrophils, T cells, and macrophages, contributing to the distinct manifestation of psoriatic lesions...
July 11, 2018: International Journal of Biological Macromolecules
Hilary E Baldwin, Linda F Stein Gold, Kenneth B Gordon, Jeremy B Green, Craig L Leonardi, Roberta D Sengelmann
Updates on managing some of the most common dermatologic conditions for which patients seek care illuminated presentations at the Skin Disease Education Foundation's 42nd Annual Hawaii Dermatology Seminar®. This educational supplement summarizes the highlights of clinical sessions presented during this CME/CE conference. Treatment of psoriasis has continued to advance, with three interleukin (IL)-17 antagonists approved by the US Food and Drug Administration (FDA) and a fourth in phase 3 trials. An authority on the use of biologics in psoriasis presents current data on the safety and efficacy of these therapies...
June 2018: Seminars in Cutaneous Medicine and Surgery
Angela Burleigh, Nordau Kanigsberg, Joseph M Lam
The mTOR inhibitor rapamycin is used systemically for the treatment of vascular lesions. We report the first use of topical rapamycin for the successful treatment of two cases of tufted angioma. The evidence for the use of topical rapamycin in other dermatologic conditions is summarized to aid in clinical decision making on preparations and anticipated side effects.
July 17, 2018: Pediatric Dermatology
Salvatore D Infusino, Camilla Loi, Giulia M Ravaioli, Bianca M Piraccini, Federico Bardazzi, Annalisa Patrizi
BACKGROUND: As a consequence of the improvement in survival after solid organ transplantation, to visit transplant recipients with neoplastic and non-neoplastic skin disorders due to immunosuppressive treatment has become common for dermatologists. METHODS: Our endpoints were: to investigate (i) the most common skin diseases in a population of transplant recipients, (ii) their associations with the type of immunosuppressant or transplant received; (iii) to compare our single centre 40-year experience with the literature data...
July 17, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Sally H Ibbotson
Narrowband UVB (NB-UVB) phototherapy and psoralen-UVA (PUVA) photochemotherapy are widely used phototherapeutic modalities for a range of skin diseases. The main indication for NB-UVB and PUVA therapies is psoriasis, and other key diagnoses include atopic eczema, vitiligo, cutaneous T-cell lymphoma (CTCL), and the photodermatoses. The decision on choice of phototherapy is important and NB-UVB is usually the primary choice. NB-UVB phototherapy is a safe and effective therapy which is usually considered when topical agents have failed...
2018: Frontiers in Medicine
Michael W Dryden, Michael S Canfield, Cara Bocon, Letitia Phan, Emily Niedfeldt, Amanda Kinnon, Stanislaw A Warcholek, Vicki Smith, Todd S Bress, Nicole Smith, Kathleen Heaney, Christine Royal, Dorothy Normile, Robert Armstrong, Fangshi Sun
BACKGROUND: An investigation was conducted in West Central Florida, USA to evaluate the efficacy of either topically applied fluralaner or topically applied selamectin to control flea infestations, minimize dermatologic lesions and reduce pruritus in naturally flea infested cats over a 12-week period. When dogs were present in the households, they were treated with either oral fluralaner (if household cats were treated with topical fluralaner) or oral sarolaner (if household cats were treated with topical selamectin)...
July 16, 2018: Parasites & Vectors
Lan Feng, Nannan Shi, Shasha Cai, Xue Qiao, Peng Chu, Hui Wang, Feida Long, Huaixin Yang, Yongliang Yang, Yipeng Wang, Haining Yu
Cutaneous hyperpigmentation from excess melanogenesis causes serious pigmentary disorders and even melasma. Short peptides (SPs) are garnering attention lately owing to their therapeutic potential in dermatological diseases and low systemic side-effects. Here, we show an octapeptide, Ansin2, de novo designed from antioxidant SPs we previously reported, significantly inhibited the melanogenesis in B16 cells by decreasing the tyrosinase production via regulating MITF pathway. Ansin2 could also inhibit the tyrosinase function by covering its catalytic pocket, simulated by docking and LIGPLOT studies...
July 16, 2018: Journal of Medicinal Chemistry
Ameni Jerbi, Hend Hachicha, Sawsan Feki, Emna Bahloul, Khadija Sellami, Olfa Abida, Slim Charfi, Amina Bouzid, Tahia Sellami Boudawara, Hamida Turki, Abderrahmen Masmoudi, Hatem Masmoudi
BACKGROUND: Pemphigus herpetiformis (PH) is a rare subtype of pemphigus combining clinical features of dermatitis herpetiformis and the immunopathologic characteristics of pemphigus. We aimed to analyze the epidemiological, clinical, and immunological presentation and management of the disease in a cohort of south Tunisian patients with a long-term follow-up. METHODS: We included all patients with confirmed PH followed from January 1987 to December 2015 in the dermatology department...
July 16, 2018: International Journal of Dermatology
Eugenia Di Meco, Anteo Di Napoli, Loredana Maria Amato, Antonio Fortino, Gianfranco Costanzo, Alessandra Rossi, Concetta Mirisola, Alessio Petrelli
Background: Since 2008 Italy has been the destination of the 'central Mediterranean route', used by migrants to reach Europe. The aim of this study is to describe demographic characteristics and health problems of migrants at the time of arrival on the Italian coasts, focussing on dermatological and infectious diseases. Methods: Cross-sectional study of data routinely collected (n = 6, 188) by the National Institute for Health Migration and Poverty (INMP) in the centres for migrants of Lampedusa and Trapani-Milo (2015-16)...
July 12, 2018: European Journal of Public Health
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