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https://www.readbyqxmd.com/read/29334301/navigating-social-distance-in-foundational-clinical-encounters-understanding-medical-students-early-experiences-with-diverse-patients
#1
Miesha Roberts-MacDonald, Saleem Razack
BACKGROUND: Social distance between patients and physicians has been shown to affect the quality of care that patients receive. Little is known about how social distance between students and patients is experienced by learners during early clinical exposures in medical school. OBJECTIVE: This study aims to explore students' stories of experiencing social distance with patients with concordant and discordant social characteristics as themselves, respectively, as well as students' needs from medical curricula regarding developing social competence...
January 15, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29332310/advances-and-current-challenges-in-calcium-signaling
#2
REVIEW
Jörg Kudla, Dirk Becker, Erwin Grill, Rainer Hedrich, Michael Hippler, Ursula Kummer, Martin Parniske, Tina Romeis, Karin Schumacher
Content I. II. III. IV. V. VI. VII VIII IX X XI ORCID References SUMMARY: Temporally and spatially defined changes in Ca2+ concentration in distinct compartments of cells represent a universal information code in plants. Recently, it has become evident that Ca2+ signals not only govern intracellular regulation but also appear to contribute to long distance or even organismic signal propagation and physiological response regulation. Ca2+ signals are shaped by an intimate interplay of channels and transporters, and during past years important contributing individual components have been identified and characterized...
January 14, 2018: New Phytologist
https://www.readbyqxmd.com/read/29331928/being-in-control-a-thematic-content-analysis-of-14-in-depth-interviews-with-2-4-dinitrophenol-users
#3
Neha Prasad Ainsworth, Elisabeth Julie Vargo, Andrea Petróczi
BACKGROUND: 2,4-Dinitrophenol (2,4-DNP) is a compound with multiple industrial purposes. Currently unlicensed for human consumption, it is used by the gym-going population for drastic, short-term body fat loss. Nonetheless, physiological mechanisms can lead to potentially fatal hyperthermia. Reported fatal incidents have caused concern and highlighted the need for intervention. Understanding decision-making leading to 2,4-DNP use alongside the perceived outgroup attitudes is vital to forming effective harm minimisation policies targeting current and potential users...
January 11, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29331478/comprehensive-analysis-of-lncrnas-and-mrnas-with-associated-co-expression-and-cerna-networks-in-c2c12-myoblasts-and-myotubes
#4
Rui Chen, Ting Jiang, Yanling She, Sidong Xie, Shanyao Zhou, Cheng Li, Jun Ou, Yulin Liu
Long non-coding RNAs (lncRNAs) are emerging as important regulators in the modulation of muscle development and muscle-related diseases. To explore potential regulators of muscle differentiation, we determined the expression profiles of lncRNAs and mRNAs in C2C12 mouse myoblast cell line using microarray analysis. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed to explore their function. We also constructed co-expression, cis/trans-regulation, and competing endogenous RNA (ceRNA) networks with bioinformatics methods...
January 10, 2018: Gene
https://www.readbyqxmd.com/read/29331398/critical-differences-between-elective-and-emergency-surgery-identifying-domains-for-quality-improvement-in-emergency-general-surgery
#5
Alexandra B Columbus, Megan A Morris, Elizabeth J Lilley, Alyssa F Harlow, Adil H Haider, Ali Salim, Joaquim M Havens
OBJECTIVE: The objective of our study was to characterize providers' impressions of factors contributing to disproportionate rates of morbidity and mortality in emergency general surgery to identify targets for care quality improvement. BACKGROUND: Emergency general surgery is characterized by a high-cost burden and disproportionate morbidity and mortality. Factors contributing to these observed disparities are not comprehensively understood and targets for quality improvement have not been formally developed...
January 10, 2018: Surgery
https://www.readbyqxmd.com/read/29331232/incorporating-behavioral-and-sensory-context-into-spectro-temporal-models-of-auditory-encoding
#6
REVIEW
Stephen V David
For several decades, auditory neuroscientists have used spectro-temporal encoding models to understand how neurons in the auditory system represent sound. Derived from early applications of systems identification tools to the auditory periphery, the spectro-temporal receptive field (STRF) and more sophisticated variants have emerged as an efficient means of characterizing representation throughout the auditory system. Most of these encoding models describe neurons as static sensory filters. However, auditory neural coding is not static...
December 31, 2017: Hearing Research
https://www.readbyqxmd.com/read/29330594/coding-valence-in-touchscreen-interactions-hand-dominance-and-lateral-movement-influence-valence-appraisals-of-emotional-pictures
#7
Sergio Cervera Torres, Susana Ruiz Fernández, Martin Lachmair, Peter Gerjets
The Body-Specificity Hypothesis postulates that the space surrounding the dominant hand is perceived as positive due to the motor fluency of this hand, whereas the space surrounding the non-dominant hand is perceived as negative. Experimental studies based on this theoretical framework also revealed associations between affective valence and hand dominance (i.e., dominant hand-positive; non-dominant hand-negative), or lateral movements of the hands (i.e., right hand toward the right space-positive; left hand toward the left space-positive)...
January 12, 2018: Psychological Research
https://www.readbyqxmd.com/read/29330239/one-year-of-family-physicians-observations-on-working-with-medical-scribes
#8
Amelia Sattler, Tracy Rydel, Cathina Nguyen, Steven Lin
PURPOSE: The immense clerical burden felt by physicians is one of the leading causes of burnout. Scribes are increasingly being used to help alleviate this burden, yet few published studies investigate how scribes affect physicians' daily work, attitudes and behaviors, and relationships with patients and the workplace. METHODS: Using a longitudinal observational design, data were collected, over 1 year, from 4 physicians working with 2 scribes at a single academic family medicine practice...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29330104/circular-rna-an-emerging-non-coding-rna-as-a-regulator-and-biomarker-in-cancer
#9
Bing Chen, Shenglin Huang
Circular RNA (circRNA) is a type of covalently closed non-coding RNA that may regulate gene expression in eukaryotes. The recent application of high-throughput RNA sequencing and bioinformatics approaches has revealed a large number of circRNAs in human cells. Emerging evidence indicates that many circRNAs have cell-type specific expression and are linked to physiological development and various diseases. Specially, circRNAs can either serve as oncogenic stimuli or tumor suppressors in cancer. circRNAs have also been shown to be enriched and stable in extracellular fluid, indicating the potential of circRNAs as cancer biomarkers...
January 9, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29329439/conserved-proteins-of-the-rna-interference-system-in-the-arbuscular-mycorrhizal-fungus-rhizoglomus-irregulare-provide-new-insight-into-the-evolutionary-history-of-glomeromycota
#10
Soon-Jae Lee, Mengxuan Kong, Paul Harrison, Mohamed Hijri
Horizontal gene transfer (HGT) is an important mechanism in the evolution of many living organisms particularly in Prokaryotes where genes are frequently dispersed between taxa. Although, HGT has been reported in Eukaryotes, its accumulative effect and its frequency has been questioned. Arbuscular mycorrhizal fungi (AMF) are an early diverged fungal lineage belonging to phylum Glomeromycota, whose phylogenetic position is still under debate. The history of AMF and land plant symbiosis dates back to at least 460 million years ago...
January 10, 2018: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29329034/long-non-coding-rna-ccat2-promotes-cholangiocarcinoma-cells-migration-and-invasion-by-induction-of-epithelial-to-mesenchymal-transition
#11
Yi Xu, Yue Yao, Wei Qin, Xiangyu Zhong, Xingming Jiang, Yunfu Cui
Cholangiocarcinoma (CCA) is one of the most aggressive malignancies in humans. Emerging evidence has indicated that abnormally expressed long non-coding RNAs (lncRNAs) could conduce to tumorigenesis and progression. Specifically, colon cancer-associated transcript 2 (CCAT2) has been reported to be overexpressed in several carcinomas. However, its clinical significance and functional roles in CCA is still unknown. qRT-PCR experiments were conducted to assess the CCAT2 expression in CCA tissue samples and cell lines...
January 9, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29328795/emerging-changing-fashion-trends-and-their-impact-on-conduct-of-anaesthesia
#12
Nadeem Zaidi
One of the innate features of human behaviour is to enhance personal image in order to look different from the rest of the crowd and to satisfy a need for individualism. People use different dress codes, body makeup and artificial gadgets to improve their personal and physical appearance. The main motive behind all these efforts is personal satisfaction, to appear attractive to others and to overcome phobias and complexes.
November 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29328003/characterizing-the-type-and-location-of-intracranial-abnormalities-in-mild-traumatic-brain-injury
#13
Harri Isokuortti, Grant L Iverson, Noah D Silverberg, Anneli Kataja, Antti Brander, Juha Öhman, Teemu M Luoto
OBJECTIVE The incidence of intracranial abnormalities after mild traumatic brain injury (TBI) varies widely across studies. This study describes the characteristics of intracranial abnormalities (acute/preexisting) in a large representative sample of head-injured patients who underwent CT imaging in an emergency department. METHODS CT scans were systematically analyzed/coded in the TBI Common Data Elements framework. Logistic regression modeling was used to quantify risk factors for traumatic intracranial abnormalities in patients with mild TBIs...
January 12, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29327358/opioid-medication-use-in-patients-with-gastrointestinal-diagnoses-vs-unexplained-gastrointestinal-symptoms-in-the-us-veterans-health-administration
#14
G S Sayuk, N Kanuri, C P Gyawali, B M Gott, B D Nix, R A Rosenheck
BACKGROUND: While opioid prescriptions have increased alarmingly in the United States (US), their use for unexplained chronic gastrointestinal (GI) pain (eg, irritable bowel syndrome) carries an especially high risk for adverse effects and questionable benefit. AIM: To compare opioid use among US veterans with structural GI diagnoses (SGID) and those with unexplained GI symptoms or functional GI diagnoses (FGID), a group for whom opioids have no accepted role. METHODS: Veterans Health Administration (VHA) administrative data from fiscal year 2012 were used to identify veterans with diagnostic codes recorded for SGID and FGID...
January 12, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29326080/light-triggerable-formulations-for-the-intracellular-controlled-release-of-biomolecules
#15
REVIEW
Miguel M Lino, Lino Ferreira
New therapies based on the use of biomolecules [e.g., proteins, peptides, and non-coding (nc)RNAs] have emerged during the past few years. Given their instability, adverse effects, and limited ability to cross cell membranes, delivery systems are required to fully reveal their biological potential. Sophisticated nanoformulations responsive to light offer an excellent opportunity for the controlled release of these biomolecules, enabling the control of timing, duration, location, and dosage. In this review, we discuss the design principles for the delivery of biomolecules, in particular proteins and RNA-based therapeutics, by light-triggerable formulations...
January 8, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29325609/the-cag-polyglutamine-repeat-diseases-a-clinical-molecular-genetic-and-pathophysiologic-nosology
#16
Colleen A Stoyas, Albert R La Spada
Throughout the genome, unstable tandem nucleotide repeats can expand to cause a variety of neurologic disorders. Expansion of a CAG triplet repeat within a coding exon gives rise to an elongated polyglutamine (polyQ) tract in the resultant protein product, and accounts for a unique category of neurodegenerative disorders, known as the CAG-polyglutamine repeat diseases. The nine members of the CAG-polyglutamine disease family include spinal and bulbar muscular atrophy (SBMA), Huntington disease, dentatorubral pallidoluysian atrophy, and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17)...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29325162/an-analysis-of-adverse-events-in-the-rehabilitation-department-using-the-veterans-affairs-root-cause-analysis-system
#17
Gregory W Hagley, Peter D Mills, Brian Shiner, Robin R Hemphill
Background: Root cause analyses (RCA) are often completed in health care settings to determine causes of adverse events (AEs). RCAs result in action plans designed to mitigate future patient harm. National reviews of RCA reports have assessed the safety of numerous health care settings and suggested opportunities for improvement. However, few studies have assessed the safety of receiving care from physical therapists, occupational therapists, or speech and language pathology pathologists...
January 9, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29324938/deontological-aspects-of-the-nursing-profession-understanding-the-code-of-ethics
#18
Terezinha Nunes da Silva, Maria Eliane Moreira Freire, Monica Ferreira de Vasconcelos, Sergio Vital da Silva Junior, Wilton José de Carvalho Silva, Patrícia da Silva Araújo, Allan Victor Assis Eloy
OBJECTIVE: to investigate nursing professionals' understanding concerning the Code of Ethics; to assess the relevance of the Code of Ethics of the nursing profession and its use in practice; to identify how problem-solving is performed when facing ethical dilemmas in professional practice. METHOD: exploratory descriptive study, conducted with 34 (thirty-four) nursing professionals from a teaching hospital in João Pessoa, PB - Brazil. RESULTS: four thematic categories emerged: conception of professional ethics in nursing practice; interpretations of ethics in the practice of care; use of the Code of Ethics in the professional practice; strategies for solving ethical issues in the professional practice...
January 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29324415/convolutional-sparse-coding-for-rgb-nir-imaging
#19
Xuemei Hu, Felix Heide, Qionghai Dai, Gordon Wetzstein
Emerging sensor designs increasingly rely on novel color filter arrays (CFAs) to sample the incident spectrum in unconventional ways. In particular, capturing a near-infrared (NIR) channel along with conventional RGB color is an exciting new imaging modality. RGB+NIR sensing has broad applications in computational photography, such as low-light denoising, it has applications in computer vision, such as facial recognition and tracking, and it paves the way toward low-cost single-sensor RGB and depth imaging using structured illumination...
April 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29322103/a-national-survey-of-mri-safety-practices-in-ghana
#20
Albert Dayor Piersson, Philip Nii Gorleku
Objective: The aim of the present study was to assess current MRI safety practices among MRI facilities in Ghana, and their compliance with the 2013 American College of Radiology (ACR) guidance document on MR safe practices. Material and methods: A questionnaire developed from the 2013 ACR Guidance Document was used to collect information on magnetic field strengths, MR safety policy and compliance, patient screening, emergency preparedness, infection control, MRI safety accessories, equipment safety, signage and barriers, report of adverse incidents, and access and communication...
December 2017: Heliyon
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