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https://www.readbyqxmd.com/read/29778546/imaging-genetics-paradigms-in-depression-research-systematic-review-and-meta-analysis
#1
REVIEW
Lícia P Pereira, Cristiano A Köhler, Brendon Stubbs, Kamilla W Miskowiak, Gerwyn Morris, Bárbara P de Freitas, Trevor Thompson, Brisa S Fernandes, André R Brunoni, Michael Maes, Diego A Pizzagalli, André F Carvalho
Imaging genetics studies involving participants with major depressive disorder (MDD) have expanded. Nevertheless, findings have been inconsistent. Thus, we conducted a systematic review and meta-analysis of imaging genetics studies that enrolled MDD participants across major databases through June 30th, 2017. Sixty-five studies met eligibility criteria (N = 4034 MDD participants and 3293 controls), and there was substantial between-study variability in the methodological quality of included studies. However, few replicated findings emerged from this literature with only 22 studies providing data for meta-analyses (882 participants with MDD and 616 controls)...
May 17, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29776586/-the-role-and-use-of-patient-reported-outcomes-in-the-management-of-cancer-patients
#2
REVIEW
Patricia Marino, Marie Bannier, Jean-François Moulin, Gwenaëlle Gravis
Therapeutic innovations in the field of oncology allow to manage cancer as a chronic illness with treatments being administered over prolonged periods of time. In this context, it is now acknowledged that it is important to complete the assessment of benefit based on purely clinical endpoints using outcome measurement evaluated by patients themselves. The Patient reported outcome (PRO) concept has then emerged and there is an increasing interest in using the PROs as an indicator of the benefit of new therapeutic strategies...
May 15, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29774918/proximity-induced-magnetism-and-an-anomalous-hall-effect-in-bi-2-se-3-lacoo-3-a-topological-insulator-ferromagnetic-insulator-thin-film-heterostructure
#3
Shanna Zhu, Dechao Meng, Genhao Liang, Gang Shi, Peng Zhao, Peng Cheng, Yongqing Li, Xiaofang Zhai, Yalin Lu, Lan Chen, Kehui Wu
Inducing magnetism in a topological insulator (TI) by exchange coupling with a ferromagnetic insulator (FMI) will break the time-reversal symmetry of topological surface states, offering possibilities to realize several predicted novel magneto-electric effects. Seeking suitable FMI materials is crucial for the coupling of heterojunctions, and yet is challenging as well and only a few kinds have been explored. In this report, we introduce epitaxial LaCoO3 thin films on a SrTiO3 substrate, which is an insulating ferromagnet with a Curie temperature of TC ∼ 85 K, to be combined with TIs for proximity coupling...
May 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29773925/predictors-of-nest-growth-diminishing-returns-for-subordinates-in-the-paper-wasp-polistes-dominula
#4
Lena Grinsted, Jeremy Field
Abstract: In cooperative breeders, subordinates that have alternative reproductive options are expected to stay and help dominant breeders only as long as they contribute to group productivity, if their fitness is linked with colony success. Female Polistes dominula paper wasps live as cooperative breeders in small groups of typically fewer than 10 females. Subordinates tend to have high-quality outside options, and so could choose alternative breeding tactics if their work efforts increased productivity negligibly...
2018: Behavioral Ecology and Sociobiology
https://www.readbyqxmd.com/read/29768291/quality-of-the-triage-of-children-with-anaphylaxis-at-the-emergency-department
#5
Esozia Arroabarren, Jorge Alvarez-Garcia, Marta Anda, Montserrat de Prada, Maria Carmen Ponce, Miriam Palacios
OBJECTIVE: Early recognition of symptoms is essential in anaphylaxis management. The Canadian Paediatric Emergency Triage and Acuity Scale prioritizes anaphylaxis to level I or II (resuscitation or emergency). We analyzed the accuracy of pediatric anaphylaxis triage. METHODS: This was a retrospective review of the triage charts (adaptation of the Canadian Paediatric Emergency Triage and Acuity Scale) of 137 children attended for anaphylaxis at our pediatric emergency department...
May 15, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29768181/description-of-hot-debriefings-after-in-hospital-cardiac-arrests-in-an-international-pediatric-quality-improvement-collaborative
#6
Todd Sweberg, Anita I Sen, Paul C Mullan, Adam Cheng, Lynda Knight, Jimena Del Castillo, Takanari Ikeyama, Roopa Seshadri, Mary Fran Hazinski, Tia Raymond, Dana E Niles, Vinay Nadkarni, Heather Wolfe
BACKGROUND: The American Heart Association recommends debriefing after attempted resuscitation from in-hospital cardiac arrest (IHCA) to improve resuscitation quality and outcomes. This is the first published study detailing the utilization, process and content of hot debriefings after pediatric IHCA. METHODS: Using prospective data from the Pediatric Resuscitation Quality Collaborative (pediRES-Q), we analyzed data from 227 arrests occurring between February 1, 2016, and August 31, 2017...
May 13, 2018: Resuscitation
https://www.readbyqxmd.com/read/29767795/quality-measurement-in-physician-staffed-emergency-medical-services-a-systematic-literature-review
#7
Helge Haugland, Oddvar Uleberg, Pål Klepstad, Andreas Krüger, Marius Rehn
Purpose: Quality measurement of physician-staffed emergency medical services (P-EMS) is necessary to improve service quality. Knowledge and consensus on this topic are scarce, making quality measurement of P-EMS a high-priority research area. The aim of this review was to identify, describe and evaluate studies of quality measurement in P-EMS. Data sources: The databases of MEDLINE and Embase were searched initially, followed by a search for included article citations in Scopus...
May 15, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29761132/the-risk-factors-of-performance-based-early-frailty-in-midlife-and-older-age
#8
Matthew J Peterson
Background: Identifying impairments prior to onset of physical frailty may inform targeted interventions. An objective, clinically feasible early frailty measure, termed performance-based early frailty (PBEF) was developed, and antecedent and current risk factors were examined. Method: Data were from N = 104 participants of the Fels Longitudinal Study. PBEF was derived from age-specific cut points for time to complete five chair stands and walk four meters. "Pre-PBEF" and "PBEF" were defined as impairment in one or both measures, respectively...
January 2018: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/29760842/appropriateness-of-extremity-magnetic-resonance-imaging-examinations-in-an-academic-emergency-department-observation-unit
#9
McKinley Glover, Ravi V Gottumukkala, Yadiel Sanchez, Brian J Yun, Theodore I Benzer, Benjamin A White, Anand M Prabhakar, Ali S Raja
Introduction: Emergency departments (ED) and hospitals face increasing challenges related to capacity, throughput, and stewardship of limited resources while maintaining high quality. Appropriate utilization of extremity magnetic resonance imaging (MRI) examinations within the emergency setting is not well known. Therefore, this study aimed to determine indications for and appropriateness of MRI of the extremities for musculoskeletal conditions in the ED observation unit (EDOU). Methods: We conducted this institutional review board-approved, retrospective study in a large, quaternary care academic center and Level I trauma center...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29756471/medication-regimen-complexity-measured-by-mrci-a-systematic-review-to-identify-health-outcomes
#10
Vanessa Alves-Conceição, Kérilin Stancine Santos Rocha, Fernanda Vilanova Nascimento Silva, Rafaella Oliveira Santos Silva, Daniel Tenório da Silva, Divaldo Pereira de Lyra-Jr
OBJECTIVE: To perform a systematic review to identify health outcomes related to medication regimen complexity as measured by the Medication Regimen Complexity Index (MRCI) instrument. DATA SOURCES: Cochrane Library, LILACS, PubMed, Scopus, EMBASE, Open Thesis, and Web of Science were searched from January 1, 2004, until April 02, 2018, using the following search terms: outcome assessment, drug therapy, and Medication Regimen Complexity Index and their synonyms in different combinations...
May 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29754670/knowledge-to-action-rationale-and-design-of-the-patient-centered-care-transitions-in-heart-failure-pact-hf-stepped-wedge-cluster-randomized-trial
#11
Harriette G C Van Spall, Shun Fu Lee, Feng Xie, Dennis T Ko, Lehana Thabane, Quazi Ibrahim, Peter R Mitoff, Michael Heffernan, Manish Maingi, Michael C Tjandrawidjaja, Mohammad I Zia, Mohamed Panju, Richard Perez, Kim D Simek, Liane Porepa, Ian D Graham, R Brian Haynes, Dilys Haughton, Stuart J Connolly
INTRODUCTION: Heart Failure (HF) is a common cause of hospitalization in older adults. The transition from hospital to home is high-risk, and gaps in transitional care can increase the risk of re-hospitalization and death. Combining health care services supported by meta-analyses, we designed the PACT-HF transitional care model. METHODS: Adopting an integrated Knowledge Translation (iKT) approach in which decision-makers and clinicians are partners in research, we implement and test the effectiveness of PACT-HF among patients hospitalized for HF...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29753448/widefield-high-frame-rate-single-photon-spad-imagers-for-spim-fcs
#12
Jan Buchholz, Jan Krieger, Claudio Bruschini, Samuel Burri, Andrei Ardelean, Edoardo Charbon, Jörg Langowski
Photon-counting sensors based on standard complementary metal-oxide-semiconductor single-photon avalanche diodes (SPADs) represent an emerging class of imagers that enable the counting and/or timing of single photons at zero readout noise (better than high-speed electron-multiplying charge-coupling devices) and over large arrays. They have seen substantial progress over the last 15 years, increasing their spatial resolution, timing accuracy, and sensitivity while reducing spurious signals such as afterpulsing and dark counts...
May 9, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29752321/redefining-quality-measurement-in-cancer-care
#13
Elizabeth A Nardi, James McCanney, Katy Winckworth-Prejsnar, Alyssa A Schatz, Kerin Adelson, Marcus Neubauer, Mary Lou Smith, Ronald Walters, Robert W Carlson
Quality measurement in oncology is increasing in significance as payment schemes shift from volume to value. As demand for quality measures increases, challenges in the development of quality measures, standardization across measures, and the limitations of health information technology have become apparent. Moreover, the time and financial burden associated with developing, tracking, and reporting quality measures are substantial. Despite these challenges, best practices and leaders in the field of quality measurement in oncology have emerged...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29750398/body-composition-fatigue-and-exercise-in-patients-with-prostate-cancer-undergoing-androgen-deprivation-therapy
#14
Robert U Newton, Emily Jeffery, Daniel A Galvão, Carolyn McIntyre, Nigel Spry, David Joseph, Jim Denham, Dennis R Taaffe
OBJECTIVES: To investigate the association between lean mass (LM) and fat mass (FM) with fatigue and vitality before and following exercise in patients with prostate cancer already undergoing androgen deprivation therapy (ADT). SUBJECTS AND METHODS: Cross-sectional associations between lean and fat mass with fatigue and/or vitality measures were examined in 229 patients (43-90 years). Prospective analysis was undertaken in 129 patients who underwent 3-6 months exercise (predominantly resistance + aerobic)...
May 11, 2018: BJU International
https://www.readbyqxmd.com/read/29749760/plant-dipeptidyl-peptidase-iv-inhibitors-as-antidiabetic-agents-a-brief-review
#15
Gulmira Turdu, Hongwei Gao, Yingying Jiang, Madina Kabas
Diabetes mellitus is an increasing public health problem in the world. Type 2 diabetes is the most common type of diabetes whose complications contribute to its high death rate. It seriously impacts healthcare systems and patients' quality of life. Therefore, effective measures and new treatment strategies are needed to solve this increasingly serious global problem. In recent years, inhibition of dipeptidyl peptidase IV (DPP-IV) has emerged as a new treatment option for Type 2 diabetes. This article reviews various plant DPP-IV inhibitors that showed inhibition toward enzyme as a major target for the management of Type 2 diabetes...
May 11, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29748799/metal-contamination-in-quail-meat-residues-sources-molecular-biomarkers-and-human-health-risk-assessment
#16
Wageh Sobhy Darwish, Amira Samir Atia, Mariam H E Khedr, Walaa Fathy Saad Eldin
Quail meat is an emerging source of high-quality animal protein. Quails are exposed to a wide range of xenobiotics such as heavy metals. In this study, residual concentrations of four toxic metals, of significant public health importance, including cadmium (Cd), lead (Pb), arsenic (As), and nickel (Ni), were determined in edible tissues of quails. In addition, metal loads were measured in water, feed, and litter samples collected from same quail farms as possible sources for quail exposure to heavy metals. The possible use of metallothionein (MT) and heat shock protein 70 (Hsp70) as molecular biomarkers of exposure to heavy metals was further investigated...
May 10, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29748230/senior-doctor-triage-sdt-a-qualitative-study-of-clinicians-views-on-senior-doctors-involvement-in-triage-and-early-assessment-of-emergency-patients
#17
Maysam Ali Abdulwahid, Janette Turner, Suzanne M Mason
INTRODUCTION: Despite the focus during the last decade on introducing interventions such as senior doctor initial assessment or senior doctor triage (SDT) to reduce emergency department (ED) crowding, there has been little attempt to identify the views of emergency healthcare professionals on such interventions. The aim of this study was to gain an understanding of SDT from the perspective of emergency hospital staff. A secondary aim of this study was to develop a definition of SDT based on the interview findings and the available literature on this process...
May 10, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29746522/changes-in-quality-of-life-and-health-status-in-patients-with-extracorporeal-life-support-a-prospective-longitudinal-study
#18
Kang-Hua Chen, Yu-Ting Chen, Shu-Ling Yeh, Li-Chueh Weng, Feng-Chun Tsai
BACKGROUND: Extracorporeal life support (ECLS) provides emergency pulmonary and cardiac assistance for patients in respiratory or cardiac failure. Most studies evaluate the success of ECLS based on patients' survival rate. However, the trajectory of health status and quality of life (QOL) should also be important considerations. The study's aim was to explore changes in health status and QOL in adult patients weaned from ECLS who survived to hospital discharge over a one-year period. STUDY DESIGN: A prospective longitudinal study was conducted from April 2012 to September 2014...
2018: PloS One
https://www.readbyqxmd.com/read/29746359/evaluation-of-a-focused-cardiac-ultrasound-protocol-in-a-pediatric-emergency-department
#19
Antonio Riera, Bevin Weeks, Beth L Emerson, Lei Chen
OBJECTIVES: The objective of this study was to evaluate the implementation of a focused cardiac ultrasound (FoCUS) protocol in a pediatric emergency department (PED). METHODS: We conducted a cross-sectional, observational, quality improvement project in a PED of an urban tertiary care children's hospital. A FoCUS protocol was collaboratively developed by pediatric cardiology and pediatric emergency medicine. This included a reference document with definitions, indications, image acquisition guidelines, and interpretation expectations...
May 9, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29738467/pido-predictive-delay-optimization-for-intertidal-wireless-sensor-networks
#20
Xinyan Zhou, Xiaoyu Ji, Bin Wang, Yushi Cheng, Zhuoran Ma, Francis Choi, Brian Helmuth, Wenyuan Xu
Intertidal habitats are among the harshest environments on the planet, and have emerged as a model system for exploring the ecological impacts of global climate change. Deploying reliable instrumentation to measure environmental conditions such as temperature is challenging in this environment. The application of wireless sensor networks (WSNs) shows considerable promise as a means of optimizing continuous data collection, but poor link quality and unstable connections between nodes, caused by harsh physical environmental conditions, bring about a delay problem...
May 8, 2018: Sensors
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