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https://www.readbyqxmd.com/read/29776011/predicting-nonadherence-to-adjuvant-endocrine-therapy-in-women-with-early-stage-breast-cancer
#1
Arden L Corter, Reuben Broom, David Porter, Vernon Harvey, Michael Findlay
BACKGROUND: Failing to take endocrine therapy (ET) as prescribed (nonadherence) increases risk of morbidity and mortality from breast cancer recurrence. We explored predictors of nonadherence, including demographic, clinical, treatment and personal factors, among women newly prescribed ET for early stage breast cancer. We also examined predictors of their thoughts about stopping treatment (TST). METHODS: A baseline survey prior to ET assessed demographics, illness beliefs, beliefs about medicines, fear of recurrence, symptoms and negative affect...
May 18, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29775990/cox-model-with-interval-censored-covariate-in-cohort-studies
#2
Soohyun Ahn, Johan Lim, Myunghee Cho Paik, Ralph L Sacco, Mitchell S Elkind
In cohort studies the outcome is often time to a particular event, and subjects are followed at regular intervals. Periodic visits may also monitor a secondary irreversible event influencing the event of primary interest, and a significant proportion of subjects develop the secondary event over the period of follow-up. The status of the secondary event serves as a time-varying covariate, but is recorded only at the times of the scheduled visits, generating incomplete time-varying covariates. While information on a typical time-varying covariate is missing for entire follow-up period except the visiting times, the status of the secondary event are unavailable only between visits where the status has changed, thus interval-censored...
May 18, 2018: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/29775989/higher-accuracy-of-the-lactate-minimum-test-compared-to-established-threshold-concepts-to-determine-maximal-lactate-steady-state-in-running
#3
Patrick Wahl, Lukas Zwingmann, Christian Manunzio, Jacob Wolf, Wilhelm Bloch
This study evaluated the accuracy of the lactate minimum test, in comparison to a graded-exercise test and established threshold concepts (OBLA and mDmax) to determine running speed at maximal lactate steady state. Eighteen subjects performed a lactate minimum test, a graded-exercise test (2.4 m·s-1 start,+0.4 m·s-1 every 5 min) and 2 or more constant-speed tests of 30 min to determine running speed at maximal lactate steady state. The lactate minimum test consisted of an initial lactate priming segment, followed by a short recovery phase...
May 18, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29775979/-the-open-retromuscular-preperitoneal-mesh-repair-of-the-incisional-lateral-hernia-technique-and-results-of-a-prospective-cohort-study
#4
Friedrich-Eckart Isemer, Ulrich Dietz, Maximilian Ackermann
INTRODUCTION: Surgical approaches to flank hernias have been poorly standardised. The most demanding issues in intermuscular net insertion are the limited area in the dorsal direction and the difficulties in fixing the net to the costal arch or the iliac crest. This is why many different surgical procedures have been published. PATIENTS/MATERIAL AND METHODS: From August 2015 to October 2016, nine patients with a primary incisional lateral hernia received open retromuscular preperitoneal mesh repair...
May 18, 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29775913/mobile-phone-based-evaluation-of-latent-tuberculosis-infection-proof-of-concept-for-an-integrated-image-capture-and-analysis-system
#5
Safa Naraghi, Tinashe Mutsvangwa, René Goliath, Molebogeng X Rangaka, Tania S Douglas
BACKGROUND: The tuberculin skin test is the most widely used method for detecting latent tuberculosis infection in adults and active tuberculosis in children. We present the development of a mobile-phone based screening tool for measuring the tuberculin skin test induration. METHOD: The tool makes use of a mobile application developed on the Android platform to capture images of an induration, and photogrammetric reconstruction using Agisoft PhotoScan to reconstruct the induration in 3D, followed by 3D measurement of the induration with the aid of functions from the Python programming language...
May 8, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29775848/long-term-outcome-in-children-with-neonatal-seizures-a-tertiary-center-experience-in-cohort-of-168-patients
#6
Biljana Vucetic Tadic, Ruzica Kravljanac, Vlada Sretenovic, Vladislav Vukomanovic
PURPOSE: The purpose of this study was to evaluate long-term outcome and assess predictors of prognosis in children with neonatal seizures (NS). METHOD: This retrospective study includes children with NS treated at our Institute from January the 1st 2005 until December the 31st 2015. The data were collected from medical charts and the electroencephalogram (EEG) database at the Institute. The predictive value was evaluated for following parameters: (1) characteristics of the patients, such as gender, gestational age, birth body weight, Apgar score, artificial ventilation; (2) etiology; (3) characteristics of seizures such as type, time of onset, resistance to treatment; and (4) EEG background activity and paroxysmal discharges...
May 15, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29775831/an-exploratory-analysis-of-spatial-variations-in-organ-donation-registration-rates-in-wales-prior-to-the-implementation-of-the-human-transplantation-wales-act-2013
#7
Nicholas Page, Gary Higgs, Mitchel Langford
Spatial variations in rates of registered organ donors have not been studied in the UK at detailed spatial scales despite some evidence of national and regional differences. By drawing on the findings from the existing literature, this study examines associations between small-area variations in rates of new registrants to the UK organ donor register (ODR) within Wales and key demographic factors. Using map-based visualisations and statistical regression methods, spatial patterns in new registrants to the ODR are identified within Wales, a country which moved to an opt-out system of consent for organ donation following the Human Transplantation (Wales) Act 2013...
May 15, 2018: Health & Place
https://www.readbyqxmd.com/read/29775809/transient-asymptomatic-pulmonary-opacities-during-osimertinib-treatment-and-its-clinical-implication
#8
Hansang Lee, Ho Yun Lee, Jong-Mu Sun, Se-Hoon Lee, Youjin Kim, Song Ee Park, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn
INTRODUCTION: Osimertinib is an oral, potent, irreversible 3rd generation EGFR tyrosine kinase inhibitor (TKI) approved for the treatment of T790M positive non-small cell lung cancer (NSCLC) patients who failed 1st or 2nd generation EGFR TKIs. Interstitial lung disease (ILD) is a rare complication with osimertinib, occurring in 1-3%. Recently, relatively high incidence of transient asymptomatic pulmonary opacities (TAPOs) which are different from ILD has been described. However, its clinical implication has not been fully determined yet...
May 15, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29775805/new-subsolid-pulmonary-nodules-in-lung-cancer-screening-a-brief-report-of-the-nelson-trial
#9
Joan E Walter, Marjolein A Heuvelmans, Uraujh Yousaf-Khan, Monique D Dorrius, Erik Thunnissen, Anna Schermann, Harry J M Groen, Carlijn M van der Aalst, Kristiaan Nackaerts, Rozemarijn Vliegenthart, Harry J de Koning, Matthijs Oudkerk
INTRODUCTION: Low-dose computed tomography (LDCT) lung cancer screening is recommended in the United States. While new solid nodules after baseline screening have a high lung cancer probability at small size and require lower size cutoff values than baseline nodules, there only is limited evidence on management of new subsolid nodules. METHODS: Within the Dutch-Belgian randomized controlled LDCT lung cancer screening trial (NELSON), 7557 participants underwent baseline screening between April 2004 and December 2006...
May 15, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29775802/nonoperative-management-of-a-severe-proximal-rectus-femoris-musculotendinous-injury-in-a-recreational-athlete-a-case-report
#10
Park Ck, Zlomislic V, Du J, Huang Bk, Chang Ey, Chang Dg
This report describes a severe injury to the proximal rectus femoris (RF) muscle in a 37-year-old recreational athlete. This injury is a relatively rare occurrence in both the general and elite athletic populations. Acute and long-term imaging and functional outcomes are described. This athlete was able to return to full activity without surgical intervention. Follow-up imaging demonstrated gross healing of both complete (or near complete) muscle and tendon tears.
May 15, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29775792/diagnostic-yield-from-screening-asymptomatic-individuals-at-high-risk-for-pancreatic-cancer-a-meta-analysis-of-cohort-studies
#11
Juan E Corral, Karl F Mareth, Douglas L Riegert-Johnson, Ananya Das, Michael B Wallace
BACKGROUND & AIMS: There have been few studies of abdominal imaging screening of individuals at high risk for pancreatic cancer (based on family history or genetic variants). We performed a meta-analysis of prospective cohort studies to determine the diagnostic yield and outcomes of abdominal imaging screening for asymptomatic individuals at high risk. METHODS: Through a systematic review of multiple electronic databases and conference proceedings through July 2017, we identified prospective cohort studies (>20 patients) of asymptomatic adults determined to be at high-risk of pancreatic cancer (lifetime risk >5%, including specific genetic-associated conditions) who were screened by endoscopic ultrasound (EUS) and/or magnetic resonance imaging (MRI) to detect pancreatic lesions...
May 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29775769/quality-of-life-after-combined-endonasal-endoscopic-odontoidectomy-and-posterior-suboccipital-decompression-and-fusion
#12
Malte Ottenhausen, Andrew F Alalade, Kavelin Rumalla, Prakash Nair, Ali Baaj, Roger Hartl, Ashutosh Kacker, Jeffrey P Greenfield, Vijay K Anand, Theodore H Schwartz
INTRODUCTION: Basilar invagination can result from a variety of systemic diseases that can weaken the structural integrity of the craniocervical junction. Definitive treatment often requires ventral decompression along with posterior decompression and fusion. Endonasal odontoidectomy is a relatively new minimal access procedure, however, quality of life after this procedure has not been reported. METHODS: We reviewed a consecutive database of endonasal odontoidectomy patients and identified those having posterior decompression and fusion...
May 15, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29775746/anthropometric-measurements-and-mortality-in-frail-older-adults
#13
Jonathan F Easton, Christopher R Stephens, Heriberto Román-Sicilia, Matteo Cesari, Mario Ulises Pérez-Zepeda
BACKGROUND: As the number of older adults increases, so does the number of frail older adults. Although anthropometry has been widely used as a way to stratify the overall mortality risk of a person, the significance of these measurements becomes blurred in the case of frail older adults who have changes in body composition. Therefore, the aim of this study is to determine the association of anthropometric measurements (body mass index, knee-adjusted height body mass index, waist-to-hip ratio and calf circumference) with mortality risk in a group of older Mexican adults...
May 15, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29775733/association-of-childhood-adiposity-measures-with-adulthood-knee-cartilage-defects-and-bone-marrow-lesions-a-25-year-cohort-study
#14
Tao Meng, Shaun Thayer, Alison Venn, Feitong Wu, Flavia Cicuttini, Lyn March, Terence Dwyer, Andrew Halliday, Marita Cross, Laura L Laslett, Graeme Jones, Changhai Ding, Benny Antony
OBJECTIVE: To describe the associations between childhood adiposity measures and adulthood knee cartilage defects and bone marrow lesions (BMLs) measured 25 years later. METHODS: 327 participants from the Australian Schools Health and Fitness Survey of 1985 (aged 7-15 years) were followed up 25 years later (aged 31-41 years). Childhood measures (weight, height and skinfolds) were collected in 1985. Body mass index (BMI), overweight status and fat mass were calculated...
May 15, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29775677/managing-type-2-diabetes-as-a-couple-the-influence-of-partners-beliefs-on-diabetes-distress-over-time
#15
Berry Emma, Davies Mark, Dempster Martin
AIMS: Partners and spouses have an important role in supporting healthy self-care in adults with Type 2 diabetes. While evidence has shown that the beliefs held by people with diabetes influence emotional wellbeing, little is known about the long-term impact of partners' illness beliefs on diabetes distress. METHODS: Persons with Type 2 diabetes (pwt2d) and their partners completed a questionnaire at baseline (N=75 couples) and 12 months later (N=45 couples). Measures included demographic/ clinical parameters, the Revised Illness Perception questionnaire, and the Diabetes Distress Scale...
May 15, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29775566/the-challenge-of-discordant-serology-in-chagas-disease-the-role-of-two-confirmatory-techniques-in-inconclusive-cases
#16
Zaira Moure, Elena Sulleiro, Laura Iniesta, Carmen Guillen, Israel Molina, M Magdalena Alcover, Cristina Riera, Tomás Pumarola, Roser Fisa
Serodiscordance in Chagas disease (CD) remains a challenge since individuals with inconclusive results are clinically complicated to manage. This work, conducted outside the endemic area, aims to compare two different confirmatory techniques for the diagnosis of CD in individuals without a definitive diagnosis, to analyze the performance of the screening techniques in this group of patients, and to describe the serological follow-up of these subjects over time. Sera from 48 individuals with repeatedly discordant results by one recombinant enzyme immunoassay (r-ELISA) and one native ELISA (n-ELISA), were included in the study...
May 15, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29775549/growth-trajectories-of-young-children-s-objectively-determined-physical-activity-sedentary-behavior-and-body-mass-index
#17
Zan Gao
PURPOSE: This study examined trajectories in children's physical activity (PA), sedentary behavior, and body mass index (BMI) for both genders, and relationships among these trajectories, from childhood through early adolescence. METHODS: A total of 261 seconds and third-grade children (135 girls; Meanage  = 7.81; 73% White) from two U.S. elementary schools participated in this study. Their objective PA, sedentary behavior, and BMI were measured yearly from 2012 to 2015...
May 18, 2018: Childhood Obesity
https://www.readbyqxmd.com/read/29775547/acute-dietary-nitrate-supplementation-does-not-attenuate-oxidative-stress-or-the-hemodynamic-response-during-submaximal-exercise-in-hypobaric-hypoxia
#18
Colin R Carriker, Paige Rombach, Brooke M Stevens, Roger A Vaughan, Ann L Gibson
PURPOSE: To investigate changes in oxidative stress, arterial oxygen saturation (SaO2), blood pressure (BP), and heart rate (HR) while exercising in hypobaric hypoxia following acute dietary nitrate supplementation. METHODS: Nine well-trained (60.8±7.8 ml/kg/min) males (29±7 years) visited the lab on 3 occasions, each separated by 1 week. Visit 1 included a maximal aerobic cycling test (VO2max) and 5 five-minute increasing intensity exercise bouts in a normobaric environment (1600m)...
May 18, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29775491/effects-of-a-home-care-mobile-app-on-the-outcomes-of-discharged-patients-with-a-stoma-a-randomized-controlled-trial
#19
Qing-Qing Wang, Jing Zhao, Xiao-Rong Huo, Ling Wu, Li-Fang Yang, Ju-Yun Li, Jie Wang
AIMS: The aim of this study is to explore the effects of a home care mobile app on the outcomes of stoma patients who discharged from hospital. BACKGROUND: Patients with a newly formed stoma experience many difficulties after surgery. Mobile application (app) has the potential to help patients self-manage their diseases and adjust to the changes in their lives and is a convenient way to ensure the continuity of care. However, there is a lack of studies about the effects of a mobile app on the transitional care for improving discharged stoma-related health outcomes...
May 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29775461/effects-of-aerobic-training-with-and-without-weight-loss-on-insulin-sensitivity-and-lipids
#20
Damon L Swift, Joseph A Houmard, Cris A Slentz, William E Kraus
PURPOSE: The purpose of this study is to evaluate the effect of exercise training with modest or greater weight loss (≥3%) or not (<3%) on insulin sensitivity, lipoprotein concentrations, and lipoprotein particle size in overweight and obese participants. METHODS: Adults (N = 163, body mass index: 25-37 [kg/m2]) participated in 8 months of exercise training. Insulin sensitivity, lipid concentrations, lipid particle size and other cardiometabolic variables were measured at baseline and follow-up...
2018: PloS One
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