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Praneeth Juvvi, A Chakkaravarthi, Sukumar Debnath
In the present work, the processing variables were optimized to retain betalain compound and their effect on quality attributes (oil content, breaking force and color) of fried beetroot chips. The beetroot slices were fried in lab scale vacuum fryer. Experimental design with temperature (86-153 °C), absolute pressure (1.3-9.7 kPa) and frying time (2.6-9.4 min) as independent variables which produced 20 different combinations, were studied using response surface methodology to study the effect of these variables on product responses...
September 2016: Journal of Food Science and Technology
Melanie E M Stamp, Anna M Jötten, Patrick W Kudella, Dominik Breyer, Florian G Strobl, Thomas M Geislinger, Achim Wixforth, Christoph Westerhausen
Cell adhesion processes are of ubiquitous importance for biomedical applications such as optimization of implant materials. Here, not only physiological conditions such as temperature or pH, but also topographical structures play crucial roles, as inflammatory reactions after surgery can diminish osseointegration. In this study, we systematically investigate cell adhesion under static, dynamic and physiologically relevant conditions employing a lab-on-a-chip system. We screen adhesion of the bone osteosarcoma cell line SaOs-2 on a titanium implant material for pH and temperature values in the physiological range and beyond, to explore the limits of cell adhesion, e...
October 21, 2016: Diagnostics
Beth Williamson, Claire Wilson, Gayle Dagnell, Robert J Riley
INTRODUCTION: Prediction of human pharmacokinetics from in vitro assays and pre-clinical data is an integral part of drug discovery. In vitro stability metabolic studies can provide an estimate of in vivo hepatic intrinsic clearance through inclusion of biological scaling factors. Many labs have personalised stability protocols including marker compounds and have adopted QC criteria and assay limits to ensure data integrity. Contract research organisations (CRO's) provide integrated drug discovery support to academic and pharmaceutical/biotechnology institutions to progress their in-house projects...
October 20, 2016: Journal of Pharmacological and Toxicological Methods
Ipsita Chakravarty, Subir Kundu
The increased threat of drug resistance has challenged the existence of several conventional and non-conventional antibiotics in the recent times. Daptomycin is a novel cyclic-lipopeptide antibiotic produced by Streptomyces roseosporus that has progressed as a significant anti-MRSA (methicillin-resistant Staphylococcus aureus) antibiotic. But, the economic practicality of this highly valued secondary metabolite is deterred by its poor production and tedious processing methodology. The present study aims at strategic improvement of Daptomycin production through morphological variations of S...
December 2016: AMB Express
Doğu Ömür Dede, Gözlem Ceylan, Burak Yilmaz
STATEMENT OF PROBLEM: Resin cements are available in various shades from different manufacturers. However, there is no standard for the optical properties of these cements, which may result in differences in the color of translucent ceramic restorations. PURPOSE: The purpose of this in vitro study was to evaluate the effects of different shades and brands of resin cements on the color of a lithium disilicate ceramic. MATERIALS AND METHODS: Ten ceramic disks (11×1...
October 17, 2016: Journal of Prosthetic Dentistry
James Gardiner, Nuwan Gunarathne, David Howard, Laurence Kenney
Collecting large datasets of amputee gait data is notoriously difficult. Additionally, collecting data on less prevalent amputations or on gait activities other than level walking and running on hard surfaces is rarely attempted. However, with the wealth of user-generated content on the Internet, the scope for collecting amputee gait data from alternative sources other than traditional gait labs is intriguing. Here we investigate the potential of YouTube videos to provide gait data on amputee walking. We use an example dataset of trans-femoral amputees level walking at self-selected speeds to collect temporal gait parameters and calculate gait asymmetry...
2016: PloS One
Saad Mohammed Dahlawi, Samreen Siddiqui
Easy availability, preparation technique, and economic value make calcium polysulphide (CaS x ) a very useful inorganic chemical for various field and industrial applications. In this article, disparate applications of CaS x solution have been reviewed to suggest potential and future consolidation. This article also encompasses the physiochemical properties and production of CaS x solution, with critical appraisal on research focusing on CaS x application in agriculture industries and removal of potentially toxic elements (PTEs) from the environment...
October 19, 2016: Environmental Science and Pollution Research International
Molly Howard, Andrew Lipshutz, Breanne Roess, Emily Hawes, Zachariah Deyo, Jena Ivey Burkhart, Stephan Moll, Betsy Bryant Shilliday
Direct Oral Anticoagulants (DOACs) require specific dosing and monitoring to ensure safe and appropriate use. The purpose of this evaluation was to identify patient- and process-related factors that correlate with increased risk of inappropriate prescribing of DOACs. A retrospective chart review was conducted in three outpatient clinics within an academic medical center to identify patients started on DOAC therapy and evaluate the appropriateness of DOAC initiation. Data collected included patient demographics, DOAC medication initiated, dose, indication, baseline laboratory values, concomitant medications, type and specialty of prescriber, and initiation setting...
October 18, 2016: Journal of Thrombosis and Thrombolysis
Shoubing Wang, Ziran Xu
Increased eutrophication in the recent years has resulted in considerable research focus on identification of methods for preventing cyanobacterial blooms that are rapid and efficient. The objectives of this study were to investigate the effects of dihydroartemisinin and artemether on the growth of Microcystis aeruginosa and to elucidate its mode of action. Variations in cell density, chlorophyll a, soluble protein, malondialdehyde, extracellular alkaline phosphatase activity (APA), and chlorophyll fluorescence parameters (Fv/Fm, ΦPSII, ETR, rapid light curves, fast chlorophyll fluorescence curves on fluorescence intensity, and relative variable fluorescence) were evaluated by lab-cultured experiments...
2016: PloS One
Matthew J Budoff, Nove Kalia, Jason Cole, Rine Nakanishi, Negin Nezarat, Joseph L Thomas
BACKGROUND: Although several studies have shown promise for noninvasive angiography by coronary computed tomographic angiography (CCTA), few prospective multicenter trials have been conducted. This study evaluated the diagnostic accuracy of Visipaque enhanced CCTA to detect obstructive coronary stenosis compared with quantitative coronary angiography (QCA). PATIENTS AND METHODS: Three sites prospectively enrolled 77 patients (58.1% men, 54 years) with chest pain referred for invasive coronary angiography (ICA)...
October 14, 2016: Coronary Artery Disease
Sanjay Kumar Dey, Pankaj Prabhakar, Manisha Saini, Toyanji Joseph, B K Thelma, Subir K Maulik, Suman Kundu
OBJECTIVE: To identify novel inhibitors of dopamine beta hydroxylase (DBH) and evaluate their antihypertensive properties in L-NAME induced hypertensive rat model. DESIGN AND METHOD: An experimentally validated computational model for hDBH, built in our lab, was used for structure-based, rational drug-design. The three-dimensional model was used for virtual-screening against small molecule databases from NCI, USA and elsewhere. Identified top hits were then tested in vitro against DBH with known inhibitors nepicastat and disulfiram as controls...
September 2016: Journal of Hypertension
Massimo Salvetti, Anna Paini, Claudia Agabiti Rosei, Deborah Stassaldi, Fabio Bertacchini, Giulia Rubagotti, Giulia Maruelli, Laura Verzeri, Carlotta Donini, Maria Lorenza Muiesan, Enrico Agabiti Rosei
OBJECTIVE: The recent results of the SPRINT study suggest that "intensive" reduction of systolic blood pressure (BP) (to less than 120 mmHg) might provide greater cardiovascular protection as compared to less intensive (< 140 mmHg) reduction of BP, at least in some subsets of patients. Only few studies, have investigated the possible effect of tight blood pressure control on indices of left ventricular hypertrophy, and have been mainly based on electrocardiography. Aim of our study was to evaluate cardiac organ damage according to "on treatment" blood pressure values in a large cohort of hypertensive patients undergoing echocardiography (2D, M-mode with conventional and tissue Doppler analysis)at the echo-lab of an ESH Excellence Centre in Italy...
September 2016: Journal of Hypertension
Yun Li, Alexandros N Vgontzas, Julio Fernandez-Mendoza, Ilia Kritikou, Maria Basta, Slobodanka Pejovic, Jordan Gaines, Edward O Bixler
STUDY OBJECTIVES: Objective and subjective measures of excessive daytime sleepiness (EDS) are only weakly associated. No study, however, has examined whether these two measures of EDS differ in terms of underlying mechanisms and prognostic value. Pro-inflammatory cytokines, i.e., interleukin-6 (IL-6) appear to promote sleepiness/fatigue, while the stress hormone cortisol promotes vigilance. We hypothesized that objective sleepiness is associated with increased levels of IL-6 and decreased levels of cortisol...
October 10, 2016: Sleep
C Aeberhard, C Steuer, C Saxer, A Huber, Z Stanga, S Mühlebach
BACKGROUND: Parenteral antiepileptic drugs are frequently used in critically ill patients for seizure control therapy or prevention. Many of these patients require additional parenteral nutrition (PN). Therefore, a parallel infusion of the frequently used antiepileptic drug levetiracetam (LEV) is interesting in terms of the restricted i.v. lines (e.g., neonates). The potential interactions of the complex PN admixture with the drug product and the appropriate admixing of a drug at effective dosages require physicochemical lab assessments to obtain specific and reliable pharmaceutical documentation for the intended admixing...
October 11, 2016: European Journal of Pharmaceutical Sciences
Jayanta Kumar Patra, Gitishree Das, Spiros Paramithiotis, Han-Seung Shin
Different types of fermented foods such as chongkukjang, doenjang, ganjang, gochujang, and kimchi are plentifully available and widely consumed in north eastern Asian countries including Korea. Among them, kimchi is one of the most popular Korean traditional food. It is prepared by fermenting the baechu cabbage together with other vegetables and lactic acid bacteria (LAB) with functional potential. Many types of ingredients are added to kimchi to enhance its taste, flavor, nutritional value, texture etc. A number of bacteria are involved in the fermentation of kimchi, but LAB are the dominant species in the fermentation process...
2016: Frontiers in Microbiology
Hafiz Azhar Ali Khan, Waseem Akram
Developing resistance management strategies for eco-friendly insecticides is essential for the management of insect pests without harming the environment. Cyromazine is a biorational insecticide with very low mammalian toxicity. Resistance to cyromazine has recently been reported in house flies from Punjab, Pakistan. In order to propose a resistance management strategy for cyromazine, experiments were planned to study risk for resistance development, possibility of cross-resistance and bio-chemical mechanisms...
October 8, 2016: Chemosphere
Alessandra Durazzo, Silvia Lisciani, Emanuela Camilli, Paolo Gabrielli, Stefania Marconi, Loretta Gambelli, Altero Aguzzi, Massimo Lucarini, Giuseppe Maiani, Gaetana Casale, Luisa Marletta
This work aims at evaluating the main nutrients (proximate, minerals), their contribution for Dietary Reference Values in Italian population, and the antioxidant properties of some popular dishes prepared in a dedicated lab-kitchen: spaghetti alle vongole, pomodori al riso, gateau di patate, carciofi alla romana, pan di Spagna. Results showed that nutrient contents and energy value varied extensively because of the variety and the nature of ingredients in the analyzed dishes, and thus defined different daily nutrient intakes and their association with health effects...
March 1, 2017: Food Chemistry
Panayiotis Pafilis, Petros Lymberakis, Kostas Sagonas, Efstratios Valakos
Environmental temperatures considerably affect the reptilian ability for thermoregulation and harsh climatic conditions may impose a highly effective body temperature regulation to lizards. Such demanding conditions are more common to extreme mainland habitats (e.g. deserts or mountains). To the contrary, islands have more benign climate conditions thanks to the thermal buffering effect of the surrounding sea. However, this favorable effect may be eliminated in small size islets where the scarcity of thermal shelters and exposure to high winds create challenging conditions...
October 2016: Journal of Thermal Biology
Jacques Theitler, Daniella Dassa, Revital Gandelman-Marton
BACKGROUND: The electroencephalogram (EEG) can support the diagnosis of epilepsy, diagnose nonconvulsive status epilepticus, and aid in the classification of epileptic seizures. Its contribution to the diagnosis of other medical conditions or to decision making in other clinical situations was not established. Practically, EEG labs frequently encounter EEG referrals that are not based on current recommendations. OBJECTIVES: To assess the value of inpatient EEG in medical decision making...
October 6, 2016: European Journal of Clinical Investigation
Jose V Venero, Mark Doyle, Moneal Shah, Vikas K Rathi, June A Yamrozik, Ronald B Williams, Diane A Vido, Geetha Rayarao, Raymond Benza, Srinivas Murali, Jerry Glass, Peter Olson, George Sokos, Robert W W Biederman
BACKGROUND: Patients with newly diagnosed dilated cardiomyopathy (DCM) and advanced heart failure have a very high morbidity and mortality with an unpredictable clinical course. We investigated the role of cardiovascular magnetic resonance (CMR) imaging using late gadolinium enhancement (LGE) in this cohort of high-risk patients. We hypothesized that LGE has high prognostic value in primary DCM patients referred for possible transplantation/left ventricular assist device (LVAD) consideration...
December 2015: ESC Heart Failure
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