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https://www.readbyqxmd.com/read/27931107/a-diffusely-enlarged-pancreas-the-un-usual-suspect
#1
Pedro Magalhães-Costa, Maria José Brito, Pedro Pinto-Marques
An 81-years-old female presented with obstructive jaundice and a non-specific clinical picture of nausea and appetite loss. Labs demonstrated a conjugated hyperbilirrubinemia (7.7 mg/dL), increased aspartate aminotransferase and alanine aminotransferase (10xULN and 8xULN, respectively), increased lactate dehydrogenase (10xULN) and serum lipase (3xULN). CA 19.9 was 342 U/mL (Ref value < 37 U/mL). There was no evidence of peripheral lymphadenopathy or hepatosplenomegaly. Imaging (Figure 1A and 1B) revealed a marked homogeneous enlargement of the pancreas (without any well-defined mass), dilation of the extra and intra-hepatic bile ducts and ascites...
December 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27930838/fermentation-profile-and-identification-of-lactic-acid-bacteria-and-yeasts-of-rehydrated-corn-kernel-silage
#2
B F Carvalho, C L S Ávila, T F Bernardes, M N Pereira, C Santos, R F Schwan
AIMS: The aim of this study was to evaluate the chemical and microbiological characteristics and to identify lactic acid bacteria (LAB) and yeasts involved in rehydrated corn kernel silage. METHODS AND RESULTS: Four replicates for each fermentation time: 5, 15, 30, 60, 90, 150, 210, and 280 days were prepared. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI TOF-MS) and PCR-based identification were utilized to identify LAB and yeasts...
December 8, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27930280/development-of-electronic-medical-record-based-rounds-report-results-in-improved-resident-efficiency-more-time-for-direct-patient-care-and-education-and-less-resident-duty-hour-violations
#3
Phillip B Ham, Toby Anderton, Ryan Gallaher, Mike Hyrman, Erika Simmerman, Annamalai Ramanathan, David Fallaw, Steven Holsten, Charles Gordon Howell
Surgeons frequently report frustration and loss of efficiency with electronic medical record (EMR) systems. Together, surgery residents and a programmer at Augusta University created a rounds report (RR) summarizing 24 hours of vitals, intake/output, labs, and other values for each inpatient that were previously transcribed by hand. The objective of this study was to evaluate the RRs effect on surgery residents. Surgery residents were queried to assess the RRs impact. Outcome measures were time spent preparing for rounds, direct patient care time, educational activity time, rates of incorrect/incomplete data on rounds, and rate of duty hour violations...
September 2016: American Surgeon
https://www.readbyqxmd.com/read/27928240/color-stability-of-nanofilled-and-microhybrid-resin-based-composites-following-exposure-to-chlorhexidine-mouthrinses-an-in-vitro-study
#4
Mahmood Khosravi, Behnaz Esmaeili, Forough Nikzad, Soraya Khafri
OBJECTIVES: This study aimed to evaluate the effects of chlorhexidine mouthrinses on color stability of nanofilled and micro-hybrid resin-based composites. MATERIALS AND METHODS: In this in-vitro study, 160 disc-shaped specimens (7x2mm) were fabricated of Filtek Z250 and Filtek Z350XT Enamel (A2 shade). The samples of each group were randomly divided into eight subgroups (n=10). The specimens were incubated in artificial saliva at 37°C for 24 hours. The baseline color values (L*, a*, b*) of each specimen were measured according to CIE LAB system using a reflection spectrophotometer...
March 2016: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27928047/validating-use-of-internet-submitted-carbon-monoxide-values-by-video-to-determine-quit-status
#5
Joshua L Karelitz, Valerie C Michael, Margaret Boldry, Kenneth A Perkins
INTRODUCTION: Daily visits to biochemically verify continuous smoking abstinence via expired-air carbon monoxide (CO) may deter participation in cessation trials. One way to reduce need for daily visits while continuing to monitor abstinence success may be use of a recent procedure to verify abstinence from daily CO values via the Internet. This method requires participants submit to study staff video recordings of themselves correctly using a CO monitor. However, it has not been clearly demonstrated that those classified quit via Internet-submitted videos of CO would be reliably classified quit when assessed in-lab...
December 7, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27927518/removal-of-infected-posterior-spinal-implants-be-prepared-to-transfuse
#6
Lindsay M Andras, Elizabeth R A Joiner, Kira Skaggs, Liam R Harris, Alexander M Broom, Amy Williams, David L Skaggs
STUDY DESIGN: Single-center retrospective review of spinal deformity patients undergoing removal of infected posterior spinal fusion implants over a 10-year period. OBJECTIVE: To evaluate the intraoperative blood loss and perioperative complications of implant removal in posterior spinal fusions. SUMMARY OF BACKGROUND DATA: To our knowledge, no studies examine blood loss or complications associated with removal of infected spinal implants in spinal deformity...
July 2016: Spine Deformity
https://www.readbyqxmd.com/read/27912878/selecting-optimum-protein-nano-carriers-for-natural-polyphenols-using-chemoinformatics-tools
#7
AbdelKader A Metwally, Sherweit H El-Ahmady, Rania M Hathout
BACKGROUND: The normal fate of any natural product with a therapeutic potential is to be formulated into an effective medicine. However, the conventional methods of selecting the suitable formulations or carriers based on the formulator experiences, trials and errors as well as materials availability do not usually yield the optimal results. HYPOTHESIS: We hypothesize the possibility of the virtual optimum selection of a protein carrier for two polyphenolic compounds widely investigated for their chemopreventive effects; resveratrol and curcumin using a combination of some chemoinformatics tools...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27912192/lab-based-investigation-of-enhanced-btex-attenuation-driven-by-groundwater-table-fluctuation
#8
Y S Yang, Panpan Li, Xi Zhang, Mingjie Li, Ying Lu, Bin Xu, Tong Yu
Groundwater fluctuation is often overlooked and lack of study in the field contaminant hydrogeology. Hydraulic force from fluctuating groundwater tables leads to dissolution and subsequent enhanced advective transport of petroleum (e.g. BTEX) in contaminated subsurface system. A laboratory investigation of effect of the groundwater table fluctuation (GTF) on BTEX transport, taking toluene as a typical compound, in a typical representative model of aquifers subjected to a daily water-table fluctuation was undertaken in this work...
November 29, 2016: Chemosphere
https://www.readbyqxmd.com/read/27909613/the-novel-laparoscopic-training-3d-model-in-urology-with-surgical-anatomic-remarks-fresh-frozen-cadaveric-tissue
#9
REVIEW
Emre Huri, Mehmet Ezer, Eddie Chan
Laparoscopic surgery is routinely used to treat many urological conditions and it is the gold standard treatment option for many surgeries such as radical nephrectomy. Due to the difficulty of learning, laparoscopic training should start outside the operating room. Although it is a very different model of laparoscopic training; the aim of this review is to show the value of human cadaveric model for laparoscopic training and present our experience in this area. Fresh frozen cadaveric model in laparoscopic training, dry lab, cadaveric model, animal models and computer based simulators are the most commonly used models for laparoscopic training...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27908627/validation-of-a-two-generational-reproduction-test-in-daphnia-magna-an-interlaboratory-exercise
#10
Carlos Barata, Bruno Campos, Claudia Rivetti, Gerald A LeBlanc, Stephanie Eytcheson, Stephanie McKnight, Marysia Tobor-Kaplon, Selinda de Vries Buitenweg, Suhyon Choi, Jinhee Choi, Elena I Sarapultseva, Marie-Agnès Coutellec, Maïra Coke, Pascal Pandard, Arnaud Chaumot, Hervé Quéau, Nicolas Delorme, Olivier Geffard, Fernando Martínez-Jerónimo, Haruna Watanabe, Norihisa Tatarazako, Isabel Lopes, João L T Pestana, Amadeu M V M Soares, Cecilia Manuela Pereira, Karel De Schamphelaere
Effects observed within one generation disregard potential detrimental effects that may appear across generations. Previously we have developed a two generation Daphnia magna reproduction test using the OECD TG 211 protocol with a few amendments, including initiating the second generation with third brood neonates produced from first generation individuals. Here we showed the results of an inter-laboratory calibration exercise among 12 partners that aimed to test the robustness and consistency of a two generation Daphnia magna reproduction test...
November 28, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27904391/non-alcoholic-beverages-from-fermented-cereals-with-increased-oligosaccharide-content
#11
Loreta Basinskiene, Grazina Juodeikiene, Daiva Vidmantiene, Maija Tenkanen, Tomas Makaravicius, Elena Bartkiene
The aim of this study is to develop a new technology for making traditional Lithuanian non-alcoholic beverage kvass from fermented cereals by extending the spectrum of raw materials (extruded rye) and applying new biotechnological resources (xylanolytic enzymes and lactic acid bacteria (LAB)) to improve its functional properties. Arabinoxylans in extruded rye were very efficiently hydrolysed into oligosaccharides by xylanolytic complex Ceremix Plus MG. Using Ceremix Plus MG and LAB fermentation, the yield of arabinoxylooligosaccharides and xylooligosaccharides in beverage was increased to 300 and 1100 mg/L, respectively...
March 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27899931/melatonin-in-plants-and-plant-culture-systems-variability-stability-and-efficient-quantification
#12
Lauren A E Erland, Abhishek Chattopadhyay, Andrew Maxwell P Jones, Praveen K Saxena
Despite growing evidence of the importance of melatonin and serotonin in the plant life, there is still much debate over the stability of melatonin, with extraction and analysis methods varying greatly from lab to lab with respect to time, temperature, light levels, extraction solvents, and mechanical disruption. The variability in methodology has created conflicting results that confound the comparison of studies to determine the role of melatonin in plant physiology. We here describe a fully validated method for the quantification of melatonin, serotonin and their biosynthetic precursors: tryptophan, tryptamine and N-acetylserotonin by liquid chromatography single quadrupole mass spectrometry (LC-MS) in diverse plant species and tissues...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27897004/identifying-genetic-associations-with-variability-in-metabolic-health-and-blood-count-laboratory-values-diving-into-the-quantitative-traits-by-leveraging-longitudinal-data-from-an-ehr
#13
Shefali S Verma, Anastasia M Lucas, Daniel R Lavage, Joseph B Leader, Raghu Metpally, Sarathbabu Krishnamurthy, Frederick Dewey, Ingrid Borecki, Alexander Lopez, John Overton, John Penn, Jeffrey Reid, Sarah A Pendergrass, Gerda Breitwieser, Marylyn D Ritchie
A wide range of patient health data is recorded in Electronic Health Records (EHR). This data includes diagnosis, surgical procedures, clinical laboratory measurements, and medication information. Together this information reflects the patient's medical history. Many studies have efficiently used this data from the EHR to find associations that are clinically relevant, either by utilizing International Classification of Diseases, version 9 (ICD-9) codes or laboratory measurements, or by designing phenotype algorithms to extract case and control status with accuracy from the EHR...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27896974/learning-attributes-of-disease-progression-from-trajectories-of-sparse-lab-values
#14
Vibhu Agarwal, Nigam H Shah
There is heterogeneity in the manifestation of diseases, therefore it is essential to understand the patterns of progression of a disease in a given population for disease management as well as for clinical research. Disease status is often summarized by repeated recordings of one or more physiological measures. As a result, historical values of these physiological measures for a population sample can be used to characterize disease progression patterns. We use a method for clustering sparse functional data for identifying sub-groups within a cohort of patients with chronic kidney disease (CKD), based on the trajectories of their Creatinine measurements...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27890457/the-role-of-whole-genome-sequencing-wgs-in-antimicrobial-susceptibility-testing-of-bacteria-report-from-the-eucast-subcommittee
#15
REVIEW
Matthew J Ellington, Oskar Ekelund, Frank M Aarestrup, Rafael Canton, Michel Doumith, Christian Giske, Hajo Grundman, Henrik Hasman, Matthew Holden, Katie L Hopkins, Jon Iredell, Gunnar Kahlmeter, Claudio U Köser, Alasdair MacGowan, Dik Mevius, Mike Mulvey, Thierry Naas, Tim Peto, Jean-Marc Rolain, Ørjan Samuelsen, Neil Woodford
Whole genome sequencing (WGS) offers the potential to predict antimicrobial susceptibility from a single assay. The European Committee on Antimicrobial Susceptibility Testing (EUCAST) established a subcommittee to review the current development status of WGS for bacterial antimicrobial susceptibility testing (AST). The published evidence for using WGS as a tool to infer antimicrobial susceptibility accurately is currently either poor or non-existent and the evidence / knowledge base requires significant expansion...
November 23, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27889157/monitoring-of-wheat-lactic-acid-bacteria-from-the-field-until-the-first-step-of-dough-fermentation
#16
Antonio Alfonzo, Claudia Miceli, Anna Nasca, Elena Franciosi, Giusi Ventimiglia, Rosalia Di Gerlando, Kieran Tuohy, Nicola Francesca, Giancarlo Moschetti, Luca Settanni
The present work was carried out to retrieve the origin of lactic acid bacteria (LAB) in sourdough. To this purpose, wheat LAB were monitored from ear harvest until the first step of fermentation for sourdough development. The influence of the geographical area and variety on LAB species/strain composition was also determined. The ears of four Triticum durum varieties (Duilio, Iride, Saragolla and Simeto) were collected from several fields located within the Palermo province (Sicily, Italy) and microbiologically investigated...
April 2017: Food Microbiology
https://www.readbyqxmd.com/read/27889143/use-of-natural-antimicrobials-to-improve-the-quality-characteristics-of-fresh-phyllo-a-dough-based-wheat-product-shelf-life-assessment
#17
Maria I Tsiraki, Layal Karam, Mohamad G Abiad, Hany M Yehia, Ioannis N Savvaidis
This study explores the effects of chitosan and natamycin on the quality of fresh "Phyllo" - a dough-based wheat product, by monitoring the microbiological, physicochemical and sensory parameters. Four different lots of phyllo samples stored under aerobic packaging conditions, in the absence or presence of the aforementioned antimicrobials, were prepared and stored at 4 °C. Microbiological data suggested that, the combination of chitosan and natamycin resulted in significant reductions (1-3 log cfu/g) of the microbial species examined (mesophilic total viable counts; TVC), yeasts/molds, psychrotrophic and lactic acid bacteria (LAB), Enterobacteriaceae and coliforms) by day 10...
April 2017: Food Microbiology
https://www.readbyqxmd.com/read/27887949/pharmacological-effects-of-a-recombinant-hpth-1-34-derived-peptide-on-ovariectomized-rats
#18
Wang Chunxiao, Gu Chengying, Jin Liang, Shi Xiaoming, Guo Feng, Yuan Junting, Wu Wenhui, Wang Yu, Liu Jingjing
A recombinant peptide Pro-Pro-[Arg(11)]hPTH(1-34)-Pro-Pro, was designed, biosynthesized, and purified in our lab (generated by substituting Arg for Leu at position 11 and adding -Pro-Pro to the carboxyl terminus of hPTH(1-34)-peptide), and reported to be capable of enhancing serum calcium level in chicken. In this investigation, we studied its impact on the structure, component, and biomechanical properties of rat bones. The pharmacological effect of Pro-Pro-[Arg(11)]hPTH(1-34)-Pro-Pro was investigated to evaluate its therapeutic potential for the treatment of osteoporosis, one of the most prevalent and rapidly spreading diseases in the world...
November 23, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27884822/a-framework-for-remission-in-sle-consensus-findings-from-a-large-international-task-force-on-definitions-of-remission-in-sle-doris
#19
Ronald van Vollenhoven, Alexandre Voskuyl, George Bertsias, Cynthia Aranow, Martin Aringer, Laurent Arnaud, Anca Askanase, Petra Balážová, Eloisa Bonfa, Hendrika Bootsma, Dimitrios Boumpas, Ian Bruce, Ricard Cervera, Ann Clarke, Cindy Coney, Nathalie Costedoat-Chalumeau, László Czirják, Ronald Derksen, Andrea Doria, Thomas Dörner, Rebecca Fischer-Betz, Ruth Fritsch-Stork, Caroline Gordon, Winfried Graninger, Noémi Györi, Frédéric Houssiau, David Isenberg, Soren Jacobsen, David Jayne, Annegret Kuhn, Veronique Le Guern, Kirsten Lerstrøm, Roger Levy, Francinne Machado-Ribeiro, Xavier Mariette, Jamil Missaykeh, Eric Morand, Marta Mosca, Murat Inanc, Sandra Navarra, Irmgard Neumann, Marzena Olesinska, Michelle Petri, Anisur Rahman, Ole Petter Rekvig, Jozef Rovensky, Yehuda Shoenfeld, Josef Smolen, Angela Tincani, Murray Urowitz, Bernadette van Leeuw, Carlos Vasconcelos, Anne Voss, Victoria P Werth, Helena Zakharova, Asad Zoma, Matthias Schneider, Michael Ward
OBJECTIVES: Treat-to-target recommendations have identified 'remission' as a target in systemic lupus erythematosus (SLE), but recognise that there is no universally accepted definition for this. Therefore, we initiated a process to achieve consensus on potential definitions for remission in SLE. METHODS: An international task force of 60 specialists and patient representatives participated in preparatory exercises, a face-to-face meeting and follow-up electronic voting...
November 24, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27876978/parasitic-infection-alters-haematology-and-immunity-parameters-of-common-carp-cyprinus-carpio-linnaeus-1758
#20
Faraz Panjvini, Safoura Abarghuei, Hossein Khara, Hossein Mohammadi Parashkoh
The present study was conducted to investigate the effects of parasite infection on haematological parameters of common carp, Cyprinus carpio. To this end, fish with same age were sampled from a warm water fish farm. After fish sampling, fish were transferred to lab for parasite study. Parasite incidence percent and density were calculated for two population carps. After parasite study, to investigate the haematological parameters, the blood sampling was carried out from two group fish i.e. infected (n = 20) and non-infected fish (n = 20)...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
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