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https://www.readbyqxmd.com/read/29344924/reliability-of-the-123i-mibg-heart-mediastinum-ratio-results-of-a-multicenter-test-retest-reproducibility-study
#1
Timothy M Bateman, Karthikeyan Ananthasubramaniam, Daniel S Berman, Myron Gerson, Robert Gropler, Milena Henzlova, Fernando Mendoza, Michael Miyamoto, Mahesh Shah, Frederick Weiland
A quantitative measurement, the Heart-to-Mediastinum (H/M) ratio of counts derived from a planar acquisition approximately 4 hours after injection of 123I-mIBG, is a strong predictor of outcomes in patients with stable class II-III heart failure and LVEF ≤ 35%. This study assessed the test-retest reproducibility of the H/M ratio in such patients. 47 subjects with class II-III systolic heart failure and LVEF ≤ 35% were tested at two time intervals separated by 5 to 14 days. Subjects were imaged twice on the same camera using the same radionuclide dose...
January 17, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29340952/rfathm6a-a-new-tool-for-predicting-m6a-sites-in-arabidopsis-thaliana
#2
Xiaofeng Wang, Renxiang Yan
We curated a reliable dataset of m6A sites in Arabidopsis thaliana, built competitive models for predicting m6A sites, extracted predominant rules from the prediction models and analyzed the most important features. In biological RNA, approximately 150 chemical modifications have been discovered, of which N6-methyladenine (m6A) is the most prevalent and abundant. This modification plays an essential role in a myriad of biological mechanisms and regulates RNA localization, nuclear export, translation, stability, alternative splicing, and other processes...
January 16, 2018: Plant Molecular Biology
https://www.readbyqxmd.com/read/29338885/concurrence-of-rheumatoid-arthritis-and-calcium-pyrophosphate-deposition-disease-a-case-collection-and-review-of-the-literature
#3
Viktoriya Sabchyshyn, Irina Konon, Lawrence M Ryan, Ann K Rosenthal
OBJECTIVE: Calcium pyrophosphate deposition disease (CPDD) is arthritis caused by calcium pyrophosphate (CPP) crystal deposition in joints. It is commonly associated with aging as well as a handful of metabolic syndromes. Recent epidemiologic studies suggest a positive association of CPDD and rheumatoid arthritis (RA). Yet how these diseases are related remains unclear. We set out to describe 21 well-characterized patients with both diagnoses. METHODS: Medical records of patients with both RA and CPDD identified at a single academic practice site were reviewed for age, gender, age of CPDD and RA onset, disease duration, joint involvement, and lab values including rheumatoid factor (RF), cyclic citrullinated peptide antibody (CCP), iron studies, and parathyroid hormone and calcium levels...
December 2, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29325818/simultaneous-determination-of-voriconazole-posaconazole-itraconazole-and-hydroxy-itraconazole-in-human-plasma-using-lcms-ms
#4
Nicole Jenkins, Marion Black, Hans G Schneider
INTRODUCTION: Invasive fungal infections are an increasing cause of mortality and morbidity in high risk patient populations such as those on immunosuppressive therapy. Triazole antifungals are recommended for the prevention and treatment of such infections. The aim of this study was to develop and validate a simple, sensitive and robust LCMS/MS method for the simultaneous analysis in human plasma of three frequently used antifungal drugs: voriconazole, posaconazole, and itraconazole...
January 8, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29325432/risk-factors-for-primary-failure-of-metallic-ureteral-stents-experience-from-a-tertiary-center
#5
Jui-Shan Hsu, Chao-Yuan Huang, Kao-Lang Liu, Po-Ming Chow
INTRODUCTION: We provide primary patency rate of metallic ureteral stents in cancer patients and investigate the factors affecting primary patency. METHODS: All cancer patients who had received metallic stents for malignant ureteral obstruction between July 2009 and November 2012 in our institute were included. No patients were excluded. Patient profiles, imaging studies, and lab data were collected. Patient profiles included age, gender, body height, body weight, body mass index, cancer types, treatment for cancer, response to cancer treatment, methods of stent insertion, and prior ordinary stents...
January 12, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29317888/antileishmanial-activity-of-lavandula-angustifolia-and-rosmarinus-officinalis-essential-oils-and-nano-emulsions-on-leishmania-major-mrho-ir-75-er
#6
Azar Shokri, Majid Saeedi, Mahdi Fakhar, Katayoun Morteza-Semnani, Masoud Keighobadi, Saeed Hosseini Teshnizi, Hamid Reza Kelidari, Siamak Sadjadi
Background: The aim of present study was to evaluate antileishmanial effects of Lavandula angustifolia (L. angustifolia) and Rosmarinus officinalis (R. officinalis) medicinal plants essential oils and nano-emulsions on Leishmania major (L. major). Methods: The present study was performed in Leishmaniasis Reference Lab at Mazandaran University of Medical Sciences, Iran during 2016-2017. The IC50 values were calculated in both the promastigote and amastigote stages in J774 macrophage in comparison with meglumine antimoniate (MA) as positive control...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29317410/derivation-of-a-system-independent-ki-for-pgp-mediated-digoxin-transport-from-system-dependent-ic50-data-by-accounting-for-the-contribution-of-additional-digoxin-transporters
#7
Aqsaa Chaudhry, Git Chung, Adam Lynn, Akshata Yalvigi, Colin Brown, Harma Ellens, Michael O'Connor, Caroline Lee, Joe Bentz
It has been previously demonstrated that IC50 values for inhibition of digoxin transport across confluent cell monolayers are system-dependent. We have applied the structural mass action kinetics model for P-glycoprotein mediated transport of digoxin across confluent cell monolayers to fit IC50 curves for inhibition of digoxin transport. The model fit digoxin IC50 data from a subset of labs participating in the P-gp IC50 Initiative (2 Caco-2 labs, 1 LLC-PK1-hMDR1-NKI lab and 2 MDCKII-hMDR1-NKI labs), as well as IC50 data for inhibition of digoxin transport through monolayers of primary human proximal tubule cells (HPTC) using eight of the same inhibitors...
January 9, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29315360/cgmanalyzer-an-r-package-for-analyzing-continuous-glucose-monitoring-studies
#8
Xiaohua Douglas Zhang, Zhaozhi Zhang, Dandan Wang
Summary: The R package CGManalyzer contains functions for analyzing data from a continuous glucose monitoring (CGM) study. It covers a wide and comprehensive range of data analysis methods including reading a series of datasets, obtaining summary statistics of glucose levels, plotting data, transforming the time stamp format, fixing missing values, evaluating the mean of daily difference (MODD) and continuous overlapping net glycemic action (CONGA), calculating multiscale sample entropy (MSE), conducting pairwise comparison, displaying results using various plots including a new type of plot called an antenna plot, etc...
January 5, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29311357/cardiovascular-risk-factors-after-adolescent-bariatric-surgery
#9
Marc P Michalsky, Thomas H Inge, Todd M Jenkins, Changchun Xie, Anita Courcoulas, Michael Helmrath, Mary L Brandt, Carroll M Harmon, Mike Chen, John B Dixon, Elaine M Urbina
BACKGROUND AND OBJECTIVES: Severely obese adolescents harbor numerous cardiovascular disease risk factors (CVD-RFs), which improve after metabolic and bariatric surgery (MBS). However, predictors of change in CVD-RFs among adolescents have not yet been reported. METHODS: The Teen-Longitudinal Assessment of Bariatric Surgery study (NCT00474318) prospectively collected anthropometric and health status data on 242 adolescents undergoing MBS at 5 centers. Predictors of change in CVD-RFs (blood pressure, lipids, glucose homeostasis, and inflammation) 3 years after Roux-en-Y gastric bypass and vertical sleeve gastrectomy were examined...
January 8, 2018: Pediatrics
https://www.readbyqxmd.com/read/29306734/establishment-of-a-reference-standard-database-for-use-in-the-qualitative-and-semi-quantitative-analysis-of-pharmaceutical-contact-materials-within-an-extractables-survey-by-gc-ms
#10
Steven A Zdravkovic, Cindy T Duong, Ashley A Hellenbrand, Steven R Duff, Alyssa L Dreger
The analysis of reference standards may be performed to enhance the qualitative and quantitative data generated by non-specific screening methods utilized in extractables studies performed on pharmaceutical contact materials. However, the establishment of a database containing relative response factor and retention index values obtained from these standards has not been published. In this study, the establishment of such a database for GC-MS, a methodology commonly included in extractables studies, on an intra-lab basis was investigated...
December 29, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29302119/teg-directed-transfusion-in-complex-cardiac-surgery-impact-on-blood-product-usage
#11
Kevin Fleming, Roberta E Redfern, Rebekah L March, Nathan Bobulski, Michael Kuehne, John T Chen, Michael Moront
Complex cardiac procedures often require blood transfusion because of surgical bleeding or coagulopathy. Thrombelastography (TEG) was introduced in our institution to direct transfusion management in cardiothoracic surgery. The goal of this study was to quantify the effect of TEG on transfusion rates peri- and postoperatively. All patients who underwent complex cardiac surgery, defined as open multiple valve repair/replacement, coronary artery bypass grafting with open valve repair/replacement, or aortic root/arch repair before and after implementation of TEG were identified and retrospectively analyzed...
December 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/29300412/the-influence-of-chemical-degradation-during-dietary-exposures-to-fish-on-biomagnification-factors-and-bioaccumulation-factors
#12
Jon A Arnot, Donald Mackay
The chemical dietary absorption efficiency (ED) quantifies the amount of chemical absorbed by an organism relative to the amount of chemical an organism is exposed to following ingestion. In particular, ED can influence the extent of bioaccumulation and biomagnification for hydrophobic chemicals. A new ED model is developed to quantify chemical process rates in the gastrointestinal tract (GIT). The new model is calibrated with critically evaluated measured ED values (n = 250) for 80 hydrophobic persistent chemicals...
January 4, 2018: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29299771/vibrio-coralliirubri-sp-nov-a-new-species-isolated-from-mucus-of-red-coral-corallium-rubrum-collected-at-procida-island-italy
#13
Annarita Poli, Ida Romano, Vincenza Mastascusa, Lorena Buono, Pierangelo Orlando, Barbara Nicolaus, Luigi Leone, Kar Wai Hong, Kok-Gan Chan, Kian Mau Goh, Javier Pascual
Strain Corallo1T was isolated from mucus of red coral (Corallium rubrum) at Punta Pizzaco (Procida island, Naples, Italy). It was characterised as a Gram-stain negative, motile, rod-shaped bacterium. Strain Corallo1T was found to show positive responses for cytochrome-c oxidase, catalase, reduction of nitrate and nitrite, β-galactosidase activity and hydrolysis of starch, xylan, peptone, Tween 40, Tween 80 and casein. Strain Corallo1T was found to be mesophilic, neutrophilic to alkalophilic and slightly halophilic...
January 3, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29299664/trends-in-urinary-diversion-after-radical-cystectomy-for-urothelial-carcinoma
#14
Kinan Bachour, Izak Faiena, Amirali Salmasi, Andrew T Lenis, David C Johnson, Aydin Pooli, Alexandra Drakaki, Allan J Pantuck, Karim Chamie
PURPOSE: To assess how trends in urinary diversion (UD) type following radical cystectomy (RC) have changed in recent years and investigate pre-operative predictors of UD type. METHODS: Data were abstracted from the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) from 2011 to 2015. We quantified the percentages of continent diversions (CD) versus incontinent diversions (ID) completed over this time frame. Using univariate and multivariable logistic regression analyses, we compared UD type across year of operation as well as predictors of type of diversion...
January 3, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29295649/is-bone-marrow-examination-always-necessary-to-establish-the-diagnosis-of-myelodysplastic-syndromes-a-proposed-non-invasive-diagnostic-model
#15
Howard S Oster, Gal Carmi, Alex Kolomansky, Erel Joffe, Irit Kaye, Ilya Kirgner, Uri Greenbaum, Doron Comaneshter, Moshe Mittelman
A non-invasive myelodysplastic syndromes (MDS) diagnostic model would allow for care while avoiding invasive bone marrow examinations (BME). BME-established MDS patients were compared to non-MDS (BME-excluded) patients. Variables (gender, age, hemoglobin (Hb), mean red blood cell corpuscular volume (MCV), platelet (PLT), and white blood cell (WBC)) were combined with multivariate logistic regression; a probability score (Y) was calculated. MDS (n = 48) and non-MDS (n = 63) patients were used to establish the model...
January 2, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29290896/prognostic-value-of-cortisol-and-thyroid-function-tests-in-poisoned-patients-admitted-to-toxicology-icu
#16
Shahin Shadnia, Nasim Zamani, Hossein Hassanian-Moghaddam, Hamed Shafaroodi, Mina Padandar, Mohammad Hasan Rezaeizadeh
BACKGROUND: Prognostic value of cortisol and thyroid function tests (TFTs) has previously been evaluated in medical ICUs. We aimed to evaluate prognostic efficacy of cortisol and TFTs in critically ill poisoned patients admitted to toxicology intensive care unit (ICU). METHODS: In a prospective study of consecutively enrolled subjects admitted to the toxicology ICU, lab analyses included TFTs (total T3 and T4 as well as TSH) and cortisol levels drawn between 8 am-10 am during period of the first 24 hours post-ingestion/exposure...
2018: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29289309/acoustofluidic-hematocrit-determination
#17
Klara Petersson, Ola Jakobsson, Pelle Ohlsson, Per Augustsson, Stefan Scheding, Johan Malm, Thomas Laurell
Hematocrit (HCT) measurements of blood from patients, blood donors and athletes are routinely performed on a daily basis. These measurements are often performed in centralized hospital labs by whole blood analyzers, which leads to long time-to-result. On site measurements, based on centrifugation can be done, but these assays require manual handling, are slow and can just measure HCT in contrast to the central lab whole blood analyzers. In this work, we present a microfluidic based method to measure HCT in blood samples by acoustic separation of whole blood into discrete regions of plasma and red blood cells...
February 13, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29288587/from-lab-to-market-an-integrated-bioprocess-design-approach-for-new-to-nature-biosurfactants-produced-by-starmerella-bombicola
#18
Lisa Van Renterghem, Sophie L K W Roelants, Niki Baccile, Katrijn Uyttersprot, Marie Claire Taelman, Bernd Everaert, Stein Mincke, Sam Ledegen, Sam Debrouwer, Kristel Scholtens, Christian Stevens, Wim Soetaert
Glycolipid microbial biosurfactants, like sophorolipids (SLs), generate high industrial interest as 100% biobased alternatives for traditional surfactants. A well-known success story is the efficient SL producer Starmerella bombicola, which reaches titers well above 200 g/L. Recent engineering attempts have enabled the production of completely new types of molecules by S. bombicola, like the 'non-symmetrical bolaform (nsBola) SLs'. As classic SLs are mostly applied in eco-friendly detergents, the possible use of these bolaform SLs in detergent applications was evaluated by scaling up the production process (150 L) and evaluating the purified product...
December 30, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29282199/comparison-of-hemoglobin-a1c-results-based-on-at-home-and-in-lab-dried-blood-spot-sampling-to-routine-venous-blood-sampling-in-lab-in-adult-patients-with-type-1-or-type-2-diabetes
#19
Thomas G Elliott, Kent C Dooley, Mira Zhang, Harlan S D Campbell, Darby J S Thompson
OBJECTIVES: Regular measurement of glycated hemoglobin (A1C) is logistically demanding. Home blotter-paper collection offers an alternative. This study tested the viability of at-home blotter-paper A1C measurement. METHODS: Objective: compare accuracy of A1C levels collected on blotter paper at home (home-blotter) and blotter-paper collection in laboratory (lab-blotter) with venous A1C (routine measurement). Agreement was assessed by Pearson correlation, Lin concordance correlation coefficient (CCC), positive and negative predictive values (PPVs, NPVs) and Bland-Altman plots and associated statistics...
December 25, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29274433/toxicity-reduction-of-ochratoxin-a-by-lactic-acid-bacteria
#20
C Luz, J Ferrer, J Mañes, G Meca
Ochratoxin A (OTA) is a mycotoxin produced by the metabolism of fungus belonging to the genus Aspergillus and Penicillium. In this paper we report, the capacity of different cultures of lactic acid bacteria (LAB) to degrade OTA present in MRS broth at both pH 3.5 and 6.5. A study of OTA reduction during gastrointestinal digestion carried out with the LAB was also performed. Taking into account the two reduction mechanisms of OTA studied in this work as the enzymatic one and the adsorption on the cell wall, as well as at pH 3...
December 20, 2017: Food and Chemical Toxicology
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