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Occupational Lung

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https://www.readbyqxmd.com/read/29046510/carcinogenicity-of-multi-walled-carbon-nanotubes-challenging-issue-on-hazard-assessment
#1
Shoji Fukushima, Tatsuya Kasai, Yumi Umeda, Makoto Ohnishi, Toshiaki Sasaki, Michiharu Matsumoto
OBJECTIVES: This report reviews the carcinogenicity of multi-walled carbon nanotubes (MWCNTs) in experimental animals, concentrating on MWNT-7, a straight fibrous MWCNT. METHODS: MWCNTs were administered to mice and rats by intraperitoneal injection, intrascrotal injection, subcutaneous injection, intratracheal instillation and inhalation. RESULTS: Intraperitoneal injection of MWNT-7 induced peritoneal mesothelioma in mice and rats. Intrascrotal injection induced peritoneal mesothelioma in rats...
October 18, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/29046010/-differential-diagnosis-of-mediastinal-and-hilar-lymphadenopathy-with-focus-on-occupational-diseases
#2
H Lux, L Barreira Cavalcante, X Baur
Hilar and mediastinal lymphadenopathy may represent a diagnostic challenge in clinical practice. This article is intended to facilitate differential diagnosis by a systematic description of relevant pathologies, notably with occupational etiology. Clinical findings of relevant diseases, i. e. of tuberculosis, chronic beryllium disease, sarcoidosis, lung cancer, malignant lymphoma, Epstein-Barr virus infection, and histoplasmosis are compared.Case history, imaging and laboratory tests have important diagnostic impact...
October 18, 2017: Pneumologie
https://www.readbyqxmd.com/read/29043785/elevated-exposures-to-polycyclic-aromatic-hydrocarbons-and-other-organic-mutagens-in-ottawa-firefighters-participating-in-emergency-on-shift-fire-suppression
#3
Jennifer L A Keir, Umme S Akhtar, David M J Matschke, Tracy L Kirkham, Hing Man Chan, Pierre Ayotte, Paul A White, Jules M Blais
Occupational exposures to combustion emissions were examined in Ottawa Fire Service (OFS) firefighters. Paired urine and dermal wipe samples (i.e., pre- and post-event) as well as personal air samples and fire event questionnaires were collected from 27 male OFS firefighters. A total of 18 OFS office workers were used as additional controls. Exposures to polycyclic aromatic hydrocarbons (PAHs) and other organic mutagens were assessed by quantification of urinary PAH metabolite levels, levels of PAHs in dermal wipes and personal air samples, and urinary mutagenicity using the Salmonella mutagenicity assay (Ames test)...
October 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29039215/a-clinical-assessment-and-lung-tissue-burden-from-an-individual-who-worked-as-a-libby-vermiculite-miner
#4
Brad Black, Ronald F Dodson, James R Bruce, Lee W Poye, Claudia Henschke, Gregory Loewen
During its days of operation (1920s-1990), the world's largest source of vermiculite was extracted from a mine located near Libby, Montana. The material mined at this site was shipped for various commercial applications to numerous sites in the United States. There was a "fibrous" component with toxic potential within the vermiculite deposit that has resulted in "asbestos-like" diseases/deaths being reported in numerous studies involving miners as well as residents of the town of Libby. The present case involves the clinical assessments of an individual who worked at the mine from 1969 to 1990...
October 17, 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/29036872/factors-influencing-the-occupational-injuries-of-physical-therapists-in-taiwan-a-hierarchical-linear-model-approach
#5
Yu-Hui Tao, Yu-Lung Wu, Wan-Yun Huang
BACKGROUND: The evidence literature suggests that physical therapy practitioners are subjected to a high probability of acquiring work-related injuries, but only a few studies have specifically investigated Taiwanese physical therapy practitioners. OBJECTIVE: This study was conducted to determine the relationships among individual and group hospital-level factors that contribute to the medical expenses for the occupational injuries of physical therapy practitioners in Taiwan...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29034672/-motivations-and-obstacles-to-occupational-disease-claims-in-lung-cancer-patients-an-exploratory-psychosocial-study
#6
Manon Britel, Olivia Pérol, Stéphanie Blois Da Conceiçao, Manon Ficty, Houria Brunet, Virginie Avrillon, Barbara Charbotel, Béatrice Fervers
PURPOSE: The proportion of lung cancers with an occupational origin has been estimated to be between 10 and 20%. They are largely under-reported, as 60% are not compensated as occupational disease. Although most patients are not familiar with the process of compensation, other factors could explain this under-reporting. The aim of this study was to identify psychosocial factors that could impact patients with occupational lung cancer to claim for compensation. METHODS: We conducted a case study involving semi-structured interviews with eight lung cancer patients enrolled in a cohort designed to systematically screen occupational exposures and propose claims for compensation to work-related cancer patients...
October 2, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/29034666/-respiratory-cancers-attributable-to-occupational-exposures-what-is-the-cost-to-society-in-france
#7
Hassan Serrier, Hélène Sultan-Taïeb, Danièle Luce, Sophie Béjean
OBJECTIVE: To estimate the social cost of respiratory cancers attributable to occupational risk factors in France in 2010. METHODS: We estimated the number of cases of respiratory cancers attributable to each identified occupational risk factor according to the attributable fractions method. We also estimated direct (costs of hospital stays, drugs, outpatient care) and indirect costs (production losses) related to morbidity (absenteeism and presenteeism) and mortality (years of lost production)...
October 2, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/29025048/meta-analysis-of-occupational-exposures-in-the-rubber-manufacturing-industry-and-risk-of-cancer
#8
Mathieu Boniol, Alice Koechlin, Peter Boyle
Background: : Occupational exposures in the rubber manufacturing industry showed an increased risk of cancer and have been classified as a group 1 carcinogen, largely from studies on workers employed before 1950s. Cancer sites considered as causally associated are bladder, lung and stomach, and leukaemia. Recent studies did not report an increased risk of cancer. Methods: A meta-analysis was conducted on observational studies published until April 2016 on occupational exposures in the rubber manufacturing industry and risk of cancer...
July 26, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29023999/occupational-exposure-to-diesel-engine-exhaust-and-serum-cytokine-levels
#9
Yufei Dai, Dianzhi Ren, Bryan A Bassig, Roel Vermeulen, Wei Hu, Yong Niu, Huawei Duan, Meng Ye, Tao Meng, Jun Xu, Ping Bin, Meili Shen, Jufang Yang, Wei Fu, Kees Meliefste, Debra Silverman, Nathaniel Rothman, Qing Lan, Yuxin Zheng
The International Agency for Research on Cancer has classified diesel engine exhaust (DEE) as a human lung carcinogen. Given that inflammation is suspected to be an important underlying mechanism of lung carcinogenesis, we evaluated the relationship between DEE exposure and the inflammatory response using data from a cross-sectional molecular epidemiology study of 41 diesel engine testing workers and 46 unexposed controls. Repeated personal exposure measurements of PM2.5 and other DEE constituents were taken for the diesel engine testing workers before blood collection...
October 12, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29021634/lipopolysaccharide-accelerates-fine-particulate-matter-induced-cell-apoptosis-in-human-lung-bronchial-epithelial-cells
#10
Qin Ru, Qi Xiong, Lin Chen, Xiang Tian, Kai Yue, Baomiao Ma, Lu Liu, Rihui Wu, Congyue Xu, Mingshan Pi, Chaoying Li
OBJECTIVES: The aim of the study has been to investigate the effect of the Standard Reference Material of fine particulate matter (SRM 2786) on cytotoxicity and apoptosis in human lung bronchial epithelial cells (16HBE cells). Whether the lipopolysaccharide (LPS)-induced inflammation could further accelerate cell apoptosis induced by SRM 2786 stimulation has also been determined. MATERIAL AND METHODS: 16HBE cells were exposed to various doses of SRM 2786 with or without LPS...
October 11, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28985139/lung-cancer-risk-from-plutonium-a-pooled-analysis-of-the-mayak-and-sellafield-worker-cohorts
#11
Michael Gillies, Irina Kuznetsova, Mikhail Sokolnikov, Richard Haylock, Jackie O'Hagan, Yulia Tsareva, Elena Labutina
In this study, lung cancer risk from occupational plutonium exposure was analyzed in a pooled cohort of Mayak and Sellafield workers, two of the most informative cohorts in the world with detailed plutonium urine monitoring programs. The pooled cohort comprised 45,817 workers: 23,443 Sellafield workers first employed during 1947-2002 with follow-up until the end of 2005 and 22,374 Mayak workers first employed during 1948-1982 with follow-up until the end of 2008. In the pooled cohort 1,195 lung cancer deaths were observed (789 Mayak, 406 Sellafield) but only 893 lung cancer incidences (509 Mayak, 384 Sellafield, due to truncated follow-up in the incidence analysis)...
October 6, 2017: Radiation Research
https://www.readbyqxmd.com/read/28983782/electronic-cigarettes-their-constituents-and-potential-links-to-asthma
#12
REVIEW
Phillip W Clapp, Ilona Jaspers
PURPOSE OF REVIEW: Vaping is gaining popularity in the USA, particularly among teens and young adults. While e-cigs are commonly represented as safer alternatives to tobacco cigarettes, little is known regarding the health effects of their short- or long-term use, especially in individuals with pre-existing respiratory diseases such as asthma. Flavored e-cig liquids (e-liquids) and e-cig aerosols contain airway irritants and toxicants that have been implicated in the pathogenesis and worsening of lung diseases...
October 5, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28979357/prevalence-of-human-hydatidosis-based-on-hospital-records-in-hamadan-west-of-iran-from-2006-to-2013
#13
Nazanin Fallah, Khadijeh Rahmati, Mohammad Fallah
BACKGROUND: The reservoir and intermediate hosts of Echinococcus granulsus and human hydatidosis are more prevalent in the Alborz and Zagros Mountains slop due to rich pastures for sheep raising. Many cases of hydatid cysts operate in local hospitals annually. The present study aimed to review the epidemiologic characteristics of the hydatidosis patients. METHODS: In this descriptive study, the medical files of 182 hydatidosis patients from main public and private hospitals in Hamadan Province, western Iran from 2006 to 2013 were reviewed...
July 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28978016/epigenomic-study-identifies-a-novel-mesenchyme-homeobox2-gli1-transcription-axis-involved-in-cancer-drug-resistance-overall-survival-and-therapy-prognosis-in-lung-cancer-patients
#14
Leonel Armas-López, Patricia Piña-Sánchez, Oscar Arrieta, Enrique Guzman de Alba, Blanca Ortiz-Quintero, Patricio Santillán-Doherty, David C Christiani, Joaquín Zúñiga, Federico Ávila-Moreno
Several homeobox-related gene (HOX) transcription factors such as mesenchyme HOX-2 (MEOX2) have previously been associated with cancer drug resistance, malignant progression and/or clinical prognostic responses in lung cancer patients; however, the mechanisms involved in these responses have yet to be elucidated. Here, an epigenomic strategy was implemented to identify novel MEOX2 gene promoter transcription targets and propose a new molecular mechanism underlying lung cancer drug resistance and poor clinical prognosis...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28972600/spirometric-and-hygienic-criteria-in-recognition-of-occupational-copd-in-poland-a-retrospective-analysis-of-medical-records
#15
Aneta Kleniewska, Jolanta Walusiak-Skorupa, Agnieszka Lipińska-Ojrzanowska, Kamila Szcześniak, Marta Wiszniewska
OBJECTIVES: Chronic obstructive pulmonary disease (COPD) may be work-related. It has been estimated that 15% of the population burden of COPD is attributable to occupational exposure. However, in Poland COPD is rarely recognized as an occupational disease. The aim of the study has been to analyze the causes of the low prevalence of work-related COPD in the context of the existing criteria as well as to analyze which part of the assessment - clinical or hygienic one - is responsible for such a low rate of occupational COPD recognitions...
October 2, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28970599/lung-cancer-in-an-orthoprosthetist-using-vermiculite
#16
Quentin Durand-Moreau, Matthieu Dezutter, Gilles Quéré, Gilles Robinet, Pierre-Yves Le Roux, Brice Loddé, Jean-Dominique Dewitte
Occupational exposure to certain substances would cause cancer. Herein, we report on a case of a 58-year-old former orthoprostethist who died from a lung adenocarcinoma. He had a 3 pack-year history of smoking and a single exposure to asbestos during his professional career. Between 1979 and 2010, he used vermiculite plaques daily to build medical prostheses, using no personal protective equipment. Contamination of vermiculite with amphibole asbestos has been described in Libby, Montana. Expert opinion on this case has raised the hypothesis of the use of this kind of vermiculite during this period and the occupational etiology of this cancer...
October 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28970595/exposure-to-cooking-fumes-and-acute-reversible-decrement-in-lung-functional-capacity
#17
Masoud Neghab, Mahdieh Delikhoon, Abbas Norouzian Baghani, Jafar Hassanzadeh
BACKGROUND: Being exposed to cooking fumes, kitchen workers are occupationally at risk of multiple respiratory hazards. No conclusive evidence exists as to whether occupational exposure to these fumes is associated with acute and chronic pulmonary effects and symptoms of respiratory diseases. OBJECTIVE: To quantify the exposure levels and evaluate possible chronic and acute pulmonary effects associated with exposure to cooking fumes. METHODS: In this cross-sectional study, 60 kitchen workers exposed to cooking fumes and 60 unexposed employees were investigated...
October 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28968774/occupational-exposure-to-diesel-engine-exhaust-and-alterations-in-immune-inflammatory-markers-a-cross-sectional-molecular-epidemiology-study-in-china
#18
Bryan A Bassig, Yufei Dai, Roel Vermeulen, Dianzhi Ren, Wei Hu, Huawei Duan, Yong Niu, Jun Xu, Meredith S Shiels, Troy J Kemp, Ligia A Pinto, Wei Fu, Kees Meliefste, Baosen Zhou, Jufang Yang, Meng Ye, Xiaowei Jia, Tao Meng, Jason Y Y Wong, Ping Bin, H Dean Hosgood, Allan Hildesheim, Debra T Silverman, Nathaniel Rothman, Yuxin Zheng, Qing Lan
The relationship between diesel engine exhaust (DEE), a known lung carcinogen, and immune/inflammatory markers that have been prospectively associated with lung cancer risk is not well understood. To provide insight into these associations, we conducted a cross-sectional molecular epidemiology study of 54 males highly occupationally exposed to DEE and 55 unexposed male controls from representative workplaces in China. We measured plasma levels of 64 immune/inflammatory markers in all subjects using Luminex bead-based assays, and compared our findings to those from a nested case-control study of these markers and lung cancer risk, which had been conducted among never-smoking women in Shanghai using the same multiplex panels...
August 9, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28967432/dermal-exposure-to-toluene-diisocyanate-and-respiratory-cancer-risk
#19
REVIEW
Robyn L Prueitt, Heather N Lynch, Ke Zu, Liuhua Shi, Julie E Goodman
Human exposure to toluene diisocyanate (TDI) occurs mainly through inhalation of vapors in occupational settings where TDI is produced or used, but dermal exposure to TDI is also possible during some operations. Because of a recent epidemiology study reporting a possible association with lung cancer risk in workers with potential dermal exposure to TDI, we evaluated the evidence from epidemiological, toxicological, and toxicokinetic studies to assess whether it is likely that dermal exposure to TDI can cause human respiratory cancers...
September 27, 2017: Environment International
https://www.readbyqxmd.com/read/28963819/risk-of-depressive-disorder-among-patients-with-head-and-neck-cancer-a-nationwide-population-based-study
#20
Chao-Yueh Fan, Hsing-Lung Chao, Chun-Shu Lin, Wen-Yen Huang, Chang-Ming Chen, Kuen-Tze Lin, Cheng-Li Lin, Chia-Hung Kao
BACKGROUND: The purpose of this study was to assess the incidence and risk of depressive disorder among patients with head and neck cancer. METHODS: We identified 48 548 patients from the National Health Insurance Research Database (NHIRD) in Taiwan who were newly diagnosed with head and neck cancer between 2000 and 2010. Each patient was randomly frequency-matched with an individual without head and neck cancer, based on index year, sex, age, occupation category, urbanization level, monthly income, and comorbidities...
September 30, 2017: Head & Neck
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