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Occupational Lung

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https://www.readbyqxmd.com/read/28204826/pathway-deviation-based-biomarker-and-multi-effect-target-identification-in-asbestos-related-squamous-cell-carcinoma-of-the-lung
#1
Jiang Du, Lin Zhang
Asbestos-related lung carcinoma is one of the most devastating occupational cancers, and effective techniques for early diagnosis are still lacking. In the present study, a systematic approach was applied to detect a potential biomarker for asbestos-related lung cancer (ARLC); in particular asbestos-related squamous cell carcinoma (ARLC-SCC). Microarray data (GSE23822) were retrieved from the Gene Expression Omnibus database, including 26 ARLC-SCCs and 30 non-asbestos-related squamous cell lung carcinomas (NARLC-SCCs)...
March 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28195659/silica-exposure-and-disease-in-semi-precious-stone-craftsmen-minas-gerais-brazil
#2
Ana Paula S Carneiro, Nayara F T Braz, Eduardo Algranti, Olivia M P A Bezerra, Natália P S Araujo, Lênio S Amaral Eng Hyg, Jean L Edmé, Annie Sobaszek, Nathalie Chérot-Kornobis
BACKGROUND: Brazil is an exporter of precious stones and craftsmen often work in poor conditions. We assessed silica-related diseases among crystal craftsmen and the complexity of its control. METHODS: Case-series including 118 subjects evaluated from 2006 to 2015, based on medical interviews, chest X-rays, spirometry, and respirable silica samples. RESULTS: Median age and length of exposure were 32 and 13 years, respectively. Silicosis, with 1/0 as a threshold, was diagnosed radiologically in 57 individuals (48...
March 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28194087/occupational-bronchiolitis-induced-by-cotton-dust-exposure-in-a-nonsmoker
#3
Richa Mittal, Pawan Gupta, Sunil K Chhabra
The most well-known disease caused by cotton dust is byssinosis though it is also associated with chronic obstructive airways disease, and very rarely, interstitial lung disease. Obliterative bronchiolitis has never been reported in this setting. We report a 63-year-old, nonsmoker male, who presented with complaints of cough and exertional dyspnoea for 10 years. He had worked in textile industry for 35 years and symptoms had persisted even after quitting. Examination revealed prolonged expiration with expiratory wheeze, and pulmonary function tests revealed severe airflow limitation with air trapping and impaired diffusion capacity...
May 2016: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28194086/silicosis-in-the-form-of-progressive-massive-fibrosis-a-diagnostic-challenge
#4
Somnath Bhattacharya, Atin Dey, Amitava Pal, Saurav Kar, Sayantan Saha
Silicosis is a major occupational lung disease with a relatively fatal and irreversible outcome. Early diagnosis for shifting the potential candidates to safe modes of workplace as well as for prevention of further progression is the cornerstone of management. Here, we present a complicated case of silicosis in the form of progressive massive fibrosis, which was initially interpreted as tuberculosis; radiological images had resemblance with tuberculosis and cryptogenic organizing pneumonia. Radiology-guided trucut biopsy was imperative to confirm the diagnosis...
May 2016: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28183200/spirometry-a-predictor-of-lung-cancer-among-asbestos-workers
#5
Beata Świątkowska, Neonila Szeszenia-Dąbrowska
OBJECTIVE: The significance of lung function as an independent risk factor for lung cancer remains unclear. The objective of the study is to answer the question if spirometry can identify patients at risk for lung cancer among people occupationally exposed to asbestos dust in the past. METHODS: In order to identify a group of individuals with the highest risk of lung cancer incidence based on lung function levels of FEV1% predicted value, we examined 6882 subjects enrolled in the health surveillance program for asbestos related diseases over the years 2000-2014...
January 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28177603/pro-inflammatory-and-pro-fibrogenic-effects-of-ionic-and-particulate-arsenide-and-indium-containing-semiconductor-materials-in-the-murine-lung
#6
Wen Jiang, Xiang Wang, Olivia J Osborne, Yingjie Du, Chong Hyun Chang, Yu-Pei Liao, Bingbing Sun, Jinhong Jiang, Zhaoxia Ji, Ruibin Li, Xiangsheng Liu, Jianqin Lu, Sijie Lin, Huan Meng, Tian Xia, André E Nel
We have recently shown that the toxicological potential of GaAs and InAs particulates in cells is size- and dissolution-dependent, tending to be more pronounced for nano- vs micron-sized particles. Whether the size-dependent dissolution and shedding of ionic III-V materials also apply to pulmonary exposure is unclear. While it has been demonstrated that micron-sized III-V particles, such as GaAs and InAs, are capable of inducing hazardous pulmonary effects in an occupational setting as well as in animal studies, the effect of submicron particles (e...
February 8, 2017: ACS Nano
https://www.readbyqxmd.com/read/28168324/pulmonary-innate-inflammatory-responses-to-agricultural-occupational-contaminants
#7
REVIEW
Ram S Sethi, David Schneberger, Chandrashekhar Charavaryamath, Baljit Singh
Agricultural workers are exposed to many contaminants and suffer from respiratory and other symptoms. Dusts, gases, microbial products and pesticide residues from farms have been linked to effects on the health of agricultural workers. Growing sets of data from in vitro and in vivo models demonstrate the role of the innate immune system, especially Toll-like receptor 4 (TLR4) and TLR9, in lung inflammation induced following exposure to contaminants in agricultural environments. Interestingly, inflammation and lung function changes appear to be discordant indicating the complexity of inflammatory responses to exposures...
February 6, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28166467/mortality-among-coast-guard-shipyard-workers-a-retrospective-cohort-study-of-specific-exposures
#8
Jennifer Rusiecki, Patricia Stewart, Dara Lee, Melannie Alexander, Srmena Krstev, Debra Silverman, Aaron Blair
In a previous analysis of a cohort of shipyard workers, we found excess mortality from all causes, lung cancer, and mesothelioma for longer work durations and in specific occupations. Here, we expand the previous analyses by evaluating mortality associated with five chemical exposures: asbestos, solvents, lead, oils/greases, and wood dust. Data were gathered retrospectively for 4,702 workers employed at the Coast Guard Shipyard, Baltimore, MD (1950-1964). The cohort was traced through 2001 for vital status...
February 6, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/28163602/differential-pattern-of-deposition-of-nanoparticles-in-the-airways-of-exposed-workers
#9
Elizabeth Fireman, Rinat Edelheit, Moshe Stark, Amir Bar Shai
Ultrafine particles (UFP) have been postulated to significantly contribute to the adverse health effects associated with exposure to particulate matter (PM). Due to their extremely small size (aerodynamic diameter <100 nm), UFP are able to deposit deep within the lung after inhalation and evade many mechanisms responsible for the clearance of larger particles. There is a lack of biologically relevant personal exposure metrics for exposure to occupational- and environmental-related micro- and nano-sized PM...
2017: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
https://www.readbyqxmd.com/read/28162043/chest-ultrasonography-in-health-surveillance-of-asbestos-related-lung-diseases
#10
Andrea Smargiassi, Giuliana Pasciuto, Ilaria Pedicelli, Erminia Lo Greco, Mariarosaria Calvello, Riccardo Inchingolo, Gioacchino Schifino, Patrizio Capoluongo, Pasquale Patriciello, Maurizio Manno, Alfonso Cirillo, Giuseppe Maria Corbo, Gino Soldati, Ivo Iavicoli
OBJECTIVES: Exposure to asbestos fibers can lead to different lung diseases, such as pleural thickening and effusion, asbestosis, mesothelioma, and lung cancer. These diseases are expected to peak in the next few years. The aim of the study was to validate ultrasonography (US) as a diagnostic tool in the management of lung diseases in subjects with a history of occupational exposure to asbestos. METHODS: Fifty-nine retired male workers previously exposed to asbestos were enrolled in the study...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28159026/design-and-validation-of-a-self-administered-questionnaire-as-an-aid-to-detection-of-occupational-exposure-to-lung-carcinogens
#11
C Pélissier, V Dutertre, P Fournel, I Gendre, J Michel Vergnon, J Kalecinski, F Tinquaut, L Fontana, F Chauvin
OBJECTIVE: Ten to thirty percent of lung cancer is thought to be of occupational origin. Lung cancer is under-declared as an occupational disease in Europe, and most declarations of occupational disease concern asbestos. The purpose of this study was to design and validate a short, sensitive self-administered questionnaire, as an aid for physicians in detecting occupational exposure to asbestos and other lung carcinogens in order to remedy occupational lung cancer under-declaration. STUDY DESIGN: Cross-sectional study...
February 2017: Public Health
https://www.readbyqxmd.com/read/28157764/reanalysis-of-reported-associations-of-beryllium-and-lung-cancer-in-a-large-occupational-cohort
#12
Paul L Mosquin, Kenneth J Rothman
OBJECTIVE: The aim of this study was to verify and extend reported associations of beryllium exposure and lung cancer by reanalyzing data from a large occupational cohort at three beryllium processing plants. METHODS: We used standardization and Poisson regression to evaluate the effect of cumulative and maximum exposure, unlagged, and lagged 10 years, adjusting for plant, employment tenure, and date of hire. Exposure was modeled either categorically or continuously using splines...
February 2, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28155007/adjustment-for-tobacco-smoking-and-alcohol-consumption-by-simultaneous-analysis-of-several-types-of-cancer
#13
Tor Haldorsen, Jan Ivar Martinsen, Kristina Kjærheim, Tom K Grimsrud
PURPOSE: Tobacco smoking and alcohol consumption are risk factors for several types of cancer and may act as confounders in aetiological studies. Large register-based cohorts often lack data on tobacco and alcohol. We present a method for computing estimates of cancer risk adjusted for tobacco and alcohol without exposure information. METHODS: We propose the use of confirmatory factor analysis models for simultaneous analysis of several cancer sites related to tobacco and alcohol...
February 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28153749/energy-landscape-of-a-gstp1-polymorph-linked-with-cytological-function-decay-in-response-to-chemical-stressors
#14
Zarrin Basharat, Azra Yasmin
Gene polymorphisms lead to varied structure and functional properties. A single nucleotide polymorphism (SNP) i.e. Ile105Val (rs1695) in glutathione S-transferase P1 (GSTP1) gene influences cytological toxicity and modulates the risk to occupational diseases. Apart from this, cancer, neuropathy, NOx, SOx and ozone mediated respiratory function decline including lung inflammation, asthma, allergy etc., have been reported in people with this missense mutation. Here, the functional properties of rs1695 polymorph are revisited through a computational approach...
April 20, 2017: Gene
https://www.readbyqxmd.com/read/28152992/absence-of-multiplicative-interactions-between-occupational-lung-carcinogens-and-tobacco-smoking-a-systematic-review-involving-asbestos-crystalline-silica-and-diesel-engine-exhaust-emissions
#15
Mohamad El Zoghbi, Pascale Salameh, Isabelle Stücker, Patrick Brochard, Fleur Delva, Aude Lacourt
BACKGROUND: Tobacco smoking is the main cause of lung cancer, but it is not the sole causal factor. Significant proportions of workers are smokers and exposed to occupational lung carcinogens. This study aims to systematically review the statistical interaction between occupational lung carcinogens and tobacco smoking, in particular asbestos, crystalline silica and diesel engine exhaust emissions. METHODS: Articles were identified using Scopus, PubMed, and Web of Science, and were limited to those published in English or French, without limitation of time...
February 2, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28149975/two-men-with-dyspnea-enlarged-lymph-nodes-%C3%A2-dx
#16
Ali Abdul-Hai, David Ergas, Miriam Katz, Stephen Dh Malnick
Systolic heart failure has been previously recognized as a cause of reversible mediastinal lymphadenopathy (MLN). Other causes of MLN include sarcoidosis, various malignancies, pulmonary infections, and occupational lung diseases. There are, however, no reports of MLN in patients with diastolic heart failure.
December 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/28144970/pulmonary-adenocarcinoma-with-epidermal-growth-factor-receptor-mutations-in-asbestos-exposed-non-smokers-a-case-series
#17
Richard L Kradin, John Iafrate, David C Christiani
BACKGROUND: Cigarette smoke and asbestos are recognized causes of lung carcinoma and together promote carcinogenesis. Adenocarcinoma is currently the most common cause of lung cancer in the USA and it has been linked to both smoking and asbestos exposure. Mutations in the epidermal growth factor gene receptor (EGFR) occur predominantly in non-smokers with adenocarcinoma. Methods Mutations in the EGFR gene were investigated using next-generation sequencing. RESULTS: We report the presence of EGFR exon point mutations in the pulmonary adenocarcinomas of three never-smokers occupationally exposed to asbestos...
February 1, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28142300/dose-dependent-immunomodulating-effects-of-endotoxin-in-allergic-airway-inflammation
#18
Sudhir Kumar, Atin Adhikari
How very high exposure levels to endotoxin in a farming environment provide protection against respiratory allergic symptoms and low-to-moderate levels of endotoxin in urban homes promote allergic response is unclear. Dose-specific bacterial endotoxin or LPS-induced tolerance mechanisms can affect lung inflammations, coupled with the Th2 immune responses. Here, we explored the effects of intranasal exposure of LPS at two different doses (based on occupational exposures during handling of agricultural wastes) in OVA-sensitized allergic wild type (WT) and TLR4-KO mice, particularly, with respect to Th2 cytokines and Tregs level...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/28141674/exposure-response-analyses-of-asbestos-and-lung-cancer-subtypes-in-a-pooled-analysis-of-case-control-studies
#19
Ann C Olsson, Roel Vermeulen, Joachim Schüz, Hans Kromhout, Beate Pesch, Susan Peters, Thomas Behrens, Lützen Portengen, Dario Mirabelli, Per Gustavsson, Benjamin Kendzia, Josue Almansa, Veronique Luzon, Jelle Vlaanderen, Isabelle Stücker, Florence Guida, Dario Consonni, Neil Caporaso, Maria Teresa Landi, John Field, Irene Brüske, Heinz-Erich Wichmann, Jack Siemiatycki, Marie-Elise Parent, Lorenzo Richiardi, Franco Merletti, Karl-Heinz Jöckel, Wolfgang Ahrens, Hermann Pohlabeln, Nils Plato, Adonina Tardón, David Zaridze, John McLaughlin, Paul Demers, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Rodica Stanescu Dumitru, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Paolo Boffetta, Bas Bueno-de-Mesquita, Francesco Forastiere, Thomas Brüning, Kurt Straif
BACKGROUND: Evidence is limited regarding risk and the shape of the exposure-response curve at low asbestos exposure levels. We estimated the exposure-response for occupational asbestos exposure and assessed the joint effect of asbestos exposure and smoking by sex and lung cancer subtype in general population studies. METHODS: We pooled 14 case-control studies conducted in 1985-2010 in Europe and Canada, including 17,705 lung cancer cases and 21,813 controls with detailed information on tobacco habits and lifetime occupations...
March 2017: Epidemiology
https://www.readbyqxmd.com/read/28141625/social-media-use-for-occupational-lung-disease
#20
Philip Harber, Gondy Leroy
PURPOSE OF REVIEW: Social media have great impact on all aspects of life throughout the world. The utilization of social media for occupational lung disease, however, has been much more limited. This article summarizes recent literature concerning social media for occupational lung disease and identifies areas for additional use. RECENT FINDINGS: Social media are used in six relevant areas: information dissemination, peer-to-peer communication, survey research data collection, participatory research and exposome data acquisition, assessing public concerns, and knowledge generation...
January 30, 2017: Current Opinion in Allergy and Clinical Immunology
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