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Occupational Lung

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https://www.readbyqxmd.com/read/29222577/occupational-prestige-trajectory-and-the-risk-of-lung-and-head-and-neck-cancer-among-men-and-women-in-france
#1
Gwenn Menvielle, Julien Dugas, Jeanna-Eve Franck, Matthieu Carton, Brigitte Trétarre, Isabelle Stücker, Danièle Luce
OBJECTIVES: This study aimed at investigating the associations between occupational prestige trajectories and lung and head and neck (HN) cancer risk and to assess to what extent smoking, alcohol drinking, and occupational exposures contribute to these associations. METHODS: Using data from the ICARE case-control study (controls (2676 men/715 women), lung cancers (2019 men/558 women), HN cancers (1793 men/305 women), we defined occupational prestige trajectories using group-based modeling of longitudinal data...
December 9, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/29217870/temporal-prediction-of-future-state-occupation-in-a-multistate-model-from-high-dimensional-baseline-covariates-via-pseudo-value-regression
#2
Sandipan Dutta, Susmita Datta, Somnath Datta
In many complex diseases such as cancer, a patient undergoes various disease stages before reaching a terminal state (say disease free or death). This fits a multistate model framework where a prognosis may be equivalent to predicting the state occupation at a future time t. With the advent of high throughput genomic and proteomic assays, a clinician may intent to use such high dimensional covariates in making better prediction of state occupation. In this article, we offer a practical solution to this problem by combining a useful technique, called pseudo value regression, with a latent factor or a penalized regression method such as the partial least squares (PLS) or the least absolute shrinkage and selection operator (LASSO), or their variants...
2017: Journal of Statistical Computation and Simulation
https://www.readbyqxmd.com/read/29216763/upregulated-mir-29c-suppresses-silica-induced-lung-fibrosis-through-the-wnt-%C3%AE-catenin-pathway-in-mice
#3
X Wang, K Xu, X Y Yang, J Liu, Q Zeng, F S Wang
Silicosis is an irreversible lung disease resulting from long-term inhalation of occupational dust containing silicon dioxide. However, the pathogenesis of silicosis has not been clearly understood yet. Accumulating evidence suggests that miR-29 may have a significant anti-fibrotic capacity, meanwhile it may relate to Wnt/β-catenin pathway. The purpose of this study was to discuss the role of miR-29 in the progression of silicosis. A lentiviral vector was constructed, named Lv-miR-29c, which was overexpressing miR-29c...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29216202/composition-and-variation-of-respiratory-microbiota-in-healthy-military-personnel
#4
Jun Hang, Nela Zavaljevski, Yu Yang, Valmik Desai, Richard C Ruck, Louis R Macareo, Richard G Jarman, Jaques Reifman, Robert A Kuschner, Paul B Keiser
Certain occupational and geographical exposures have been associated with an increased risk of lung disease. As a baseline for future studies, we sought to characterize the upper respiratory microbiomes of healthy military personnel in a garrison environment. Nasal, oropharyngeal, and nasopharyngeal swabs were collected from 50 healthy active duty volunteers eight times over the course of one year (1107 swabs, completion rate = 92.25%) and subjected to pyrosequencing of the V1-V3 region of 16S rDNA. Respiratory bacterial taxa were characterized at the genus level, using QIIME 1...
2017: PloS One
https://www.readbyqxmd.com/read/29215915/perspectives-on-the-relevance-of-the-circadian-time-structure-to-workplace-threshold-limit-values-and-employee-biological-monitoring
#5
Michael H Smolensky, Alain E Reinberg, Linda Sackett-Lundeen
The circadian time structure (CTS) and its disruption by rotating and nightshift schedules relative to work performance, accident risk, and health/wellbeing have long been areas of occupational medicine research. Yet, there has been little exploration of the relevance of the CTS to setting short-term, time-weighted, and ceiling threshold limit values (TLVs); conducting employee biological monitoring (BM); and establishing normative reference biological exposure indices (BEIs). Numerous publications during the past six decades document the CTS substantially affects the disposition - absorption, distribution, metabolism, and elimination - and effects of medications...
December 7, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29211772/occupational-endotoxin-exposure-in-association-with-atopic-sensitization-and-respiratory-health-in-adults-results-of-a-5-year-follow-up
#6
Elisabeth A J Spierenburg, Lidwien A M Smit, Esmeralda J M Krop, Dick Heederik, Machteld N Hylkema, Inge M Wouters
The objective of the present longitudinal study was to investigate the effects of occupational endotoxin exposure on respiratory health and atopic sensitization in adults. Health outcomes and personal endotoxin exposure estimates were determined for 234 farmers and agricultural workers both at baseline and 5 years later. A questionnaire was used to assess respiratory symptoms, spirometry tests were performed and total and specific IgE levels were measured in serum. A twofold increase in personal endotoxin exposure was associated with less hay fever (OR 0...
2017: PloS One
https://www.readbyqxmd.com/read/29200134/medical-monitoring-for-occupational-asthma-among-toluene-diisocyanate-production-workers-in-the-united-states
#7
Laura D Cassidy, Brent Doney, Mei Lin Wang, Laura Kurth, Patrick R Conner, James J Collins, Michael Carson, Don Molenaar, Carrie A Redlich, Eileen Storey
OBJECTIVE: The aim of this study was to describe a study of medical monitoring methods and lessons learned in detecting health outcomes in U.S. plants producing toluene diisocyanate (TDI). METHODS: A multidisciplinary team implemented a medical and environmental monitoring program in three TDI plants. RESULTS: Of 269 eligible workers, 197 (73%) participated and 42 (21%) met symptom and/or lung function criteria that would trigger evaluation for possible asthma over 5 years of data collection...
December 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29199263/determination-of-crystalline-silica-in-respirable-dust-upon-occupational-exposure-for-egyptian-workers
#8
Sabrein H Mohamed, Aida L El-Ansary, Eman M Abd El-Aziz
Crystalline free silica is considered as a lung carcinogen and the occupational exposure to its dust is a health hazard to workers employed in industries that involve ores of mineral dust. In Egypt, thousands of people work under conditions of silica dust exposure exceeding the occupational exposure limit, as a result the monitoring of this occupational exposure to crystalline silica dust is required by government legislation. The assessment of the later is a multi-phase process, depend on workplace measurements, quantitative analyses of samples, and comparison of results with the permissible limits...
December 2, 2017: Industrial Health
https://www.readbyqxmd.com/read/29191587/phenotypes-of-lung-cancer-and-statistical-interactions-between-tobacco-smoking-and-occupational-exposure-to-asbestos-and-crystalline-silica-from-a-large-case-only-study-the-capromat-study
#9
Mohamad El Zoghbi, Pascale Salameh, Isabelle Stücker, Christophe Paris, Jean Claude Pairon, Antoine Gislard, Jack Siemiatycki, Vincent Bonneterre, Bénédicte Clin, Patrick Brochard, Fleur Delva, Aude Lacourt
OBJECTIVES: The aim of this study was to assess the effect modification of the association between tobacco smoking and phenotypes of lung cancer (histological type, tumor location, and age at diagnosis) by occupational exposure to asbestos or to crystalline silica. MATERIALS AND METHODS: The CaProMat study is a pooled case-only study including 7256 male lung cancer cases recruited between 1996 and 2011 in France and Canada. Two job-exposure matrices (JEMs) were used to assess occupational exposure to asbestos and crystalline silica...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29187476/a-case-of-the-resected-lymphohistiocytoid-mesothelioma-bap1-is-a-key-of-accurate-diagnosis
#10
Taichi Matsubara, Gouji Toyokawa, Yuichi Yamada, Kazuki Nabeshima, Naoki Haratake, Yuka Kozuma, Takaki Akamine, Shinkichi Takamori, Fumihiro Shoji, Tatsuro Okamoto, Yoshihiko Maehara
BACKGROUND: Malignant mesothelioma (MM) is a well-known malignant tumor that occurs in the pleura and is histopathologically classified into three subtypes. Lymphohistiocytoid mesothelioma (LHM) is considered a variant of epithelioid MM, and few cases have been reported. First case of LHM was reported by Henderson et al. in 1988. It is difficult to precisely diagnose LHM, and it is often misdiagnosed as reactive mesothelial cell proliferation. CASE REPORT: An 82-year-old man, with the smoking history of nine pack-years, was referred to our Department due to an abnormal shadow and pleural effusion in the left lung field on the chest X-ray imaging...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29186624/local-and-systemic-inflammation-may-mediate-diesel-engine-exhaust-induced-lung-function-impairment-in-a-chinese-occupational-cohort
#11
Haitao Wang, Huawei Duan, Tao Meng, Mo Yang, Lianhua Cui, Ping Bin, Yufei Dai, Yong Niu, Meili Shen, Liping Zhang, Yuxin Zheng, Shuguang Leng
Diesel exhaust (DE) as the major source of vehicle-emitted particle matter in ambient air impairs lung function. The objectives were to assess the contribution of local (e.g., the fraction of exhaled nitric oxide [FeNO] and serum Club cell secretory protein [CC16]) and systemic (e.g., serum C-reaction protein [CRP] and interleukin-6 [IL-6]) inflammation to DE induced lung function impairment using a unique cohort of diesel engine testers (DET, n = 137) and non-DETs (n = 127), made up of current and non-current smokers...
November 23, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29185785/functional-outcomes-of-motor-vehicle-crash-thoracic-injuries-in-pediatric-and-adult-occupants
#12
Samantha L Schoell, Ashley A Weaver, Jennifer W Talton, Ryan T Barnard, Gretchen Baker, Joel D Stitzel, Mark R Zonfrillo
OBJECTIVE: Characterization of the severity of injury should account for both mortality and disability. The objective of this study was to develop a disability metric for thoracic injuries in motor vehicle crashes (MVCs), and compare the functional outcomes between the pediatric and adult populations. METHODS: Disability risk (DR) was quantified using Functional Independence Measure (FIM) scores within the National Trauma Data Bank for the most frequently occurring Abbreviated Injury Scale (AIS) 2-5 thoracic injuries...
November 29, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29179515/characteristics-survival-and-risk-factors-of-chinese-young-lung-cancer-patients-the-experience-from-two-institutions
#13
Jianjie Li, Fan Yang, Xiao Li, Min Zhang, Ruozi Fu, Xiaodan Yin, Jun Wang
Limited data is available regarding lung cancer in Chinese young adults. This study was aimed to determine the characteristics, survival, and prognostic factors of young lung cancer patients in China. We reviewed demographic and clinical data, and survival information of 420 young patients (20-45 years old) diagnosed with lung cancer in two Chinese hospitals between 2000 and 2013. The results showed that lung cancer occurred more frequently (70%) and affected more males than females (43.8% vs 26.7%) in patients older than 36; whereas, more females were affected under age 35 (16...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29170806/environmentally-prevalent-polycyclic-aromatic-hydrocarbons-can-elicit-co-carcinogenic-properties-in-an-in-vitro-murine-lung-epithelial-cell-model
#14
Alison K Bauer, Kalpana Velmurugan, Sabine Plöttner, Katelyn J Siegrist, Deedee Romo, Peter Welge, Thomas Brüning, Ka-Na Xiong, Heiko U Käfferlein
Low molecular weight (LMW) polycyclic aromatic hydrocarbons (PAH) are the most abundant PAHs environmentally, occupationally, and are in cigarette smoke; however, little is known about their carcinogenic potential. We hypothesized that LMW PAHs act as co-carcinogens in the presence of a known carcinogen (benzo[a]pyrene (B[a]P)) in a mouse non-tumorigenic type II cell line (C10 cells). Gap junctions are commonly suppressed and inflammation induced during tumor promotion, while DNA-adduct formation is observed during the initiation stage of cancer...
November 23, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29167298/prevalence-and-burden-of-chronic-bronchitis-symptoms-results-from-the-bold-study
#15
Filip Mejza, Louisa Gnatiuc, A Sonia Buist, William M Vollmer, Bernd Lamprecht, Daniel O Obaseki, Pawel Nastalek, Ewa Nizankowska-Mogilnicka, Peter G J Burney
We studied the prevalence, burden and potential risk factors for chronic bronchitis symptoms in the Burden of Obstructive Lung Disease study.Representative population-based samples of adults aged ≥40 years were selected in participating sites. Participants completed questionnaires and spirometry. Chronic bronchitis symptoms were defined as chronic cough and phlegm on most days for ≥3 months each year for ≥2 years.Data from 24 855 subjects from 33 sites in 29 countries were analysed. There were significant differences in the prevalence of self-reported symptoms meeting our definition of chronic bronchitis across sites, from 10...
November 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29166147/preliminary-results-of-lung-cancer-screening-in-a-socioeconomically-disadvantaged-population
#16
Phillip L Guichet, Beringia Y Liu, Bhushan Desai, Zul Surani, Steven Y Cen, Christopher Lee
OBJECTIVE: The objective of our study was to describe the preliminary results of our clinical low-dose CT (LDCT) lung cancer screening program targeting a minority, socioeconomically disadvantaged, high-risk population different from that studied in the National Lung Screening Trial (NLST). MATERIALS AND METHODS: Community partner clinics in an underserved region of south Los Angeles County referred interested candidates to our program. All patients met National Comprehensive Cancer Network eligibility criteria for lung cancer screening...
November 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29165683/systematic-review-occupational-illness-in-the-waste-and-recycling-sector
#17
C J M Poole, S Basu
Background: The waste and recycling sector is a growing part of industry. Whether health surveillance is indicated and how it should be undertaken is unclear. Aims: To undertake a review of the literature to identify hazards to health, biological effects and occupational illnesses for workers in the sector. Methods: A systematic review of the published literature and two UK databases. Results: Rates of fatal, non-fatal injuries and self-reported work-related illness were found to be higher in the waste and recycling sector than in UK industry as a whole...
November 20, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29165430/subcutaneous-administration-of-infliximab-attenuated-silica-induced-lung-fibrosis
#18
Hua Zhang, Jun-Na Sui, Lei Gao, Jian Guo
OBJECTIVES: To investigate the influence of the anti-tumor necrosis factor-α infliximab (IFX) in the case of rats with silicosis. MATERIAL AND METHODS: Forty-eight Wistar rats were randomly divided into 3 groups. The study group (N = 16) - silicosis was induced by intratracheal instillation of 50 mg silica on day 1, and IFX was subcutaneously administered at a dose of 15 mg/kg of body weight from day 2 to day 6, the vehicle group (N = 16) - silica used as the study group but without IFX, the sham group (N = 16) - 1 ml of saline was intratracheal-used...
November 21, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/29165103/occupation-exposed-to-road-traffic-emissions-and-respiratory-health-among-congolese-transit-workers-particularly-bus-conductors-in-kinshasa-a-cross-sectional-study
#19
Etongola Papy Mbelambela, Ryoji Hirota, Masamitsu Eitoku, Sifa Marie Joelle Muchanga, Hidenori Kiyosawa, Kahoko Yasumitsu-Lovell, Ontshick Leader Lawanga, Narufumi Suganuma
OBJECTIVES: Road-traffic emissions (RTE) induce adverse health effects, notably respiratory symptoms and respiratory diseases, as a result of pollutants deposited into the respiratory tract. The aim of this study was to evaluate the association between occupation groups of Congolese transit workers exposed to RTE, particularly bus conductors and respiratory health, in Kinshasa. METHODS: A cross-sectional study was conducted from 2015 April 20(th) to May 14(th), whose participants were bus conductors (n = 110), bus drivers (n = 107), taxi-motorcyclists (n = 102) and high school teachers (control group; n = 106)...
March 20, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29160385/usual-interstitial-pneumonia-typical-possible-and-inconsistent-patterns
#20
Pedro Paulo Teixeira E Silva Torres, Marcelo Fouad Rabahi, Maria Auxiliadora Carmo Moreira, Gustavo de Souza Portes Meirelles, Edson Marchiori
Idiopathic pulmonary fibrosis is a severe and progressive chronic fibrosing interstitial lung disease, a definitive diagnosis being established by specific combinations of clinical, radiological, and pathological findings. According to current international guidelines, HRCT plays a key role in establishing a diagnosis of usual interstitial pneumonia (UIP). Current guidelines describe three UIP patterns based on HRCT findings: a typical UIP pattern; a pattern designated "possible UIP"; and a pattern designated "inconsistent with UIP", each pattern having important diagnostic implications...
September 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
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