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Occupational Lung

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https://www.readbyqxmd.com/read/29466814/-dgp-interstitial-lung-disease-patient-questionnaire
#1
M Kreuter, U Ochmann, D Koschel, J Behr, F Bonella, M Claussen, U Costabel, S Jungmann, M Kolb, D Nowak, F Petermann, M Pfeiffer, M Polke, A Prasse, J Schreiber, J Wälscher, H Wirtz, D Kirsten
BACKGROUND:  Interstitial lung diseases (ILD) encompass different heterogeneous, mainly chronic diseases of the pulmonary interstitium and/or alveoli with known and unknown reasons. The diagnostic of ILD is challenging and should be performed interdisciplinary. The medical history is of major importance and therefore, in German-speaking countries the Frankfurter Bogen (published in 1985) was utilised to scrutinise the medical history of the patient. This by now more than 30-years-old questionnaire requires a revision with regard to content and language...
February 21, 2018: Pneumologie
https://www.readbyqxmd.com/read/29465110/james-craufurd-gregory-19th-century-scottish-physicians-and-the-link-between-occupation-as-a-coal-miner-and-lung-disease
#2
K Donaldson, W A Wallace, T A Elliot, C Henry
By the mid-19th century about 200,000 miners were employed in a UK coal mining industry still growing with the advances of the Industrial Revolution. Coal miners were long known to suffer poor health but the link to inhaling dust in the mines had not been made. In 1813 George Pearson was the first to suggest that darkening of lungs seen in normal individuals as they aged was caused by inhaled soot from burning oil, candles and coal, which were the common domestic sources of heat and light. In 1831 Dr James Craufurd Gregory first described black pigmentation and disease in the lungs of a deceased coal miner and linked this to pulmonary accumulation of coal mine dust...
September 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29462211/lung-cancer-and-socioeconomic-status-in-a-pooled-analysis-of-case-control-studies
#3
Jan Hovanec, Jack Siemiatycki, David I Conway, Ann Olsson, Isabelle Stücker, Florence Guida, Karl-Heinz Jöckel, Hermann Pohlabeln, Wolfgang Ahrens, Irene Brüske, Heinz-Erich Wichmann, Per Gustavsson, Dario Consonni, Franco Merletti, Lorenzo Richiardi, Lorenzo Simonato, Cristina Fortes, Marie-Elise Parent, John McLaughlin, Paul Demers, Maria Teresa Landi, Neil Caporaso, Adonina Tardón, David Zaridze, Neonila Szeszenia-Dabrowska, Peter Rudnai, Jolanta Lissowska, Eleonora Fabianova, John Field, Rodica Stanescu Dumitru, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Hans Kromhout, Roel Vermeulen, Paolo Boffetta, Kurt Straif, Joachim Schüz, Benjamin Kendzia, Beate Pesch, Thomas Brüning, Thomas Behrens
BACKGROUND: An association between low socioeconomic status (SES) and lung cancer has been observed in several studies, but often without adequate control for smoking behavior. We studied the association between lung cancer and occupationally derived SES, using data from the international pooled SYNERGY study. METHODS: Twelve case-control studies from Europe and Canada were included in the analysis. Based on occupational histories of study participants we measured SES using the International Socio-Economic Index of Occupational Status (ISEI) and the European Socio-economic Classification (ESeC)...
2018: PloS One
https://www.readbyqxmd.com/read/29461276/health-surveillance-for-occupational-asthma
#4
David Fishwick, Steve Forman
PURPOSE OF REVIEW: The outcome for workers with occupational asthma is improved for those with an earlier diagnosis. Health surveillance at work is in principle designed to identify such cases, so that the risks to the individual worker, and coworkers, can be reduced. There is recent evidence to suggest that the uptake and quality of such surveillance could be improved. This review has assessed current approaches to health surveillance for occupational asthma. RECENT FINDINGS: The article covers a review of the utility of questionnaires, lung function testing, immunological investigations, and other tests, including exhaled nitric oxide, sputum eosinophilia, and exhaled breath condensate specifically in the context of workplace-based health surveillance...
February 15, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29459517/reduced-lung-function-and-cerebral-small-vessel-disease-in-japanese-men-the-shiga-epidemiological-study-of-subclinical-atherosclerosis-sessa
#5
Ruriko Seto-Yukimura, Emiko Ogawa, Takashi Hisamatsu, Sayuki Torii, Akihiko Shiino, Kazuhiko Nozaki, Akira Fujiyoshi, Katsuyuki Miura, Yasutaka Nakano, Hirotsugu Ueshima
AIM: We aimed to investigate the association between reduced lung function and cerebral small vessel diseases via cranial magnetic resonance imaging (MRI) in the cross-sectional study of the general Japanese population. METHODS: We recruited participants aged ≥40 years from the general population of a single city in Japan. We clarified the comorbidities and treatments, smoking habits, second-hand smoke exposure, current alcohol consumption, education level, exercise habits, and occupation...
February 16, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29459480/occupational-exposure-to-pesticides-is-associated-with-differential-dna-methylation
#6
Diana A van der Plaat, Kim de Jong, Maaike de Vries, Cleo C van Diemen, Ivana Nedeljković, Najaf Amin, Hans Kromhout, Roel Vermeulen, Dirkje S Postma, Cornelia M van Duijn, H Marike Boezen, Judith M Vonk
OBJECTIVES: Occupational pesticide exposure is associated with a wide range of diseases, including lung diseases, but it is largely unknown how pesticides influence airway disease pathogenesis. A potential mechanism might be through epigenetic mechanisms, like DNA methylation. Therefore, we assessed associations between occupational exposure to pesticides and genome-wide DNA methylation sites. METHODS: 1561 subjects of LifeLines were included with either no (n=1392), low (n=108) or high (n=61) exposure to any type of pesticides (estimated based on current or last held job)...
February 19, 2018: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29451776/short-term-pulmonary-toxicity-assessment-of-pre-and-post-incinerated-organomodified-nanoclay-in-mice
#7
Todd A Stueckle, Donna C Davidson, Ray Derk, Tiffany G Kornberg, Lori Battelli, Sherri Friend, Marlene Orandle, Alixandra Wagner, Cerasela Zoica Dinu, Konstantinos A Sierros, Sushant Agarwal, Rakesh K Gupta, Yon Rojanasakul, Dale W Porter, Liying Rojanasakul
Organomodified nanoclays (ONCs) are increasingly used as filler materials to improve nanocomposite strength, wettability, flammability, and durability. However, pulmonary risks associated with exposure along their chemical lifecycle are unknown. This study's objective was to compare pre- and post-incinerated forms of uncoated and organomodified nanoclays for potential pulmonary inflammation, toxicity, and systemic blood response. Mice were exposed via aspiration to low (30 µg) and high (300 µg) doses of pre-incinerated uncoated montmorillonite nanoclay (CloisNa), ONC (Clois30B), their respective incinerated forms (I-CloisNa and I-Clois30B), and crystalline silica (CS)...
February 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/29451393/cleaning-at-home-and-at-work-in-relation-to-lung-function-decline-and-airway-obstruction
#8
Øistein Svanes, Randi J Bertelsen, Stein Hl Lygre, Anne E Carsin, Josep M Antó, Bertil Forsberg, José M García-García, José A Gullón, Joachim Heinrich, Mathias Holm, Manolis Kogevinas, Isabel Urrutia, Bénédicte Leynaert, Jesús M Moratalla, Nicole Le Moual, Theodore Lytras, Dan Norbäck, Dennis Nowak, Mario Olivieri, Isabelle Pin, Nicole Probst-Hensch, Vivi Schlünssen, Torben Sigsgaard, Trude D Skorge, Simona Villani, Debbie Jarvis, Jan P Zock, Cecilie Svanes
RATIONALE: Cleaning tasks may imply exposure to chemical agents with potential harmful effects to the respiratory system, and increased risk of asthma and respiratory symptoms among professional cleaners and in persons cleaning at home has been reported. The long-term consequences of cleaning agents on respiratory health are, however, not well described. OBJECTIVES: This paper aims to investigate long-term effects of occupational cleaning and cleaning at home on lung function decline and chronic airway obstruction...
February 16, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29447338/exposure-lag-response-in-longitudinal-studies-application-of-distributed-lag-non-linear-models-in-an-occupational-cohort
#9
Andreas M Neophytou, Sally Picciotto, Daniel M Brown, Lisa E Gallagher, Harvey Checkoway, Ellen A Eisen, Sadie Costello
Prolonged exposures can have complex relationships with health outcomes, as timing, duration, and intensity of exposure are all potentially relevant. Summary measures such as cumulative exposure or average intensity of exposure may not fully capture these relationships. We applied penalized and unpenalized distributed lag non-linear models (DLNMs) with flexible exposure-response and lag-response functions in order to examine the association between crystalline silica exposure and mortality from lung cancer and non-malignant respiratory disease in a cohort study of 2,342 California diatomaceous earth workers, followed 1942-2011...
February 13, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29445634/evaluation-of-respiratory-symptoms-among-workers-in-an-automobile-manufacturing-factory-iran
#10
Bahram Harati, Seyed Jamaleddin Shahtaheri, Ali Karimi, Kamal Azam, Alireza Ahmadi, Maryam Afzali Rad, Ali Harati
Background: This study estimated the prevalence of respiratory symptoms and disorders among workers exposed to exposure to volatile organic compound (VOCs) in an automobile manufacturing factory in Tehran, Iran in 2016. Methods: Subjects of this case-control research were included 80 samples including 40 workers exposed to different level of BTEX as well as 40 unexposed individuals were considered as control group. Methods 1501 and 7602 presented by the National Institute of Occupational Safety and Health (NIOSH) were used for the sampling and analysis of compounds in the air...
February 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29445503/overview-of-occupational-cancer-in-painters-in-korea
#11
REVIEW
Jun-Pyo Myong, Younmo Cho, Min Choi, Hyoung-Ryoul Kim
Comprehensive consideration is necessary for setting guidelines to evaluate evidence of occupational cancer in painters due to work-related exposure to carcinogens in paint (a phenomenon termed herein as "work-relatedness"). The aim of the present research is to perform a comprehensive review and to suggest criteria for the provision of compensation for occupational neoplasm among painters in Korea. In order to perform a comprehensive review, this study assessed and evaluated scientific reports of carcinogenicities from the International Agency for Research on Cancer (IARC) and the Industrial Injuries Advisory Council (IIAC), as well as reviewed the existing literature about occupational exposure among painters in Korea and the epidemiologic investigations of claimed cases of cancer among painters in Korea...
2018: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29432934/alpha-1-antitrypsin-deficiency-from-the-lung-to-the-heart
#12
Ivan Curjuric, Medea Imboden, Robert Bettschart, Seraina Caviezel, Julia Dratva, Marco Pons, Thomas Rothe, Arno Schmidt-Trucksäss, Daiana Stolz, Gian Andri Thun, Arnold von Eckardstein, Florian Kronenberg, Ilaria Ferrarotti, Nicole M Probst-Hensch
BACKGROUND AND AIMS: Alpha-1 antitrypsin (A1AT) is the most abundant serine protease inhibitor in human blood and exerts important anti-inflammatory and immune-modulatory effects. In combination with smoking or other long-term noxious exposures such as occupational dust and fumes, genetic A1AT deficiency can cause chronic obstructive pulmonary disease, a condition with elevated cardiovascular risk. The effects of A1AT deficiency on cardiovascular risk have hardly been studied today. METHODS: Using data from 2614 adults from the population-based SAPALDIA cohort, we tested associations of serum A1AT and SERPINA1 mutations with carotid intima-media thickness (CIMT, measured by B-mode ultrasonography) or self-reported arterial hypertension or cardiovascular disease in multiple regression models using a Mendelian Randomization like analysis design...
January 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29429127/tissue-and-strain-specific-effects-of-a-genotoxic-carcinogen-1-3-butadiene-on-chromatin-and-transcription
#13
Jennifer W Israel, Grace A Chappell, Jeremy M Simon, Sebastian Pott, Alexias Safi, Lauren Lewis, Paul Cotney, Hala S Boulos, Wanda Bodnar, Jason D Lieb, Gregory E Crawford, Terrence S Furey, Ivan Rusyn
Epigenetic effects of environmental chemicals are under intense investigation to fill existing knowledge gaps between environmental/occupational exposures and adverse health outcomes. Chromatin accessibility is one prominent mechanism of epigenetic control of transcription, and understanding of the chemical effects on both could inform the causal role of epigenetic alterations in disease mechanisms. In this study, we hypothesized that baseline variability in chromatin organization and transcription profiles among various tissues and mouse strains influence the outcome of exposure to the DNA damaging chemical 1,3-butadiene...
February 10, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29426194/assessment-of-occupational-exposure-to-engineered-nanomaterials-in-research-laboratories-using-personal-monitors
#14
Ivo Iavicoli, Luca Fontana, Pasqualantonio Pingue, Ana Maria Todea, Christof Asbach
Exposure assessment is a key stage in the risk assessment/management of engineered nanomaterials. Although different sampling strategies and instruments have been used to define the occupational exposure to nano-scale materials, currently there is no international consensus regarding measurement strategy, metrics and limit values. In fact, the assessment of individual exposure to engineered nanomaterials remains a critical issue despite recent innovative developments in personal monitors and samplers. Hence, we used several of these instruments to evaluate the workers' personal exposure in a large research laboratory where engineered nanomaterials are produced, handled, and characterized in order to provide input data for nanomaterial exposure assessment strategies and future epidemiological studies...
January 31, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29423230/review-of-carcinogenicity-of-hexavalent-chrome-and-proposal-of-revising-approval-standards-for-an-occupational-cancers-in-korea
#15
Jungwon Kim, Sangyun Seo, Yangho Kim, Dae Hwan Kim
Background: The objective of this study is to suggest revised recognition standards for occupational disease due to chromium (VI) by reflecting recent domestic and international research works and considering domestic exposure status with respect to target organs, exposure period, and cumulative exposure dose in relation to the chromium (VI)-induced occupational disease compensation. Methods: In this study, the reports published by major international institutions such as World Health Organization (WHO) International Agency for Research on Cancer (IARC) (2012), Occupational Safety and Health Administration (OSHA) (2006), National Institute for Occupational Safety and Health (NIOSH) (2013), American Conference of Governmental Industrial Hygienists (ACGIH) (2004), National Toxicology Program (NTP) (2014), and Agency for Toxic Substances and Disease Registry (ASTDR) (2012) were reviewed and the recent research works searched by PubMed were summarized...
2018: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29423227/silica-exposure-and-work-relatedness-evaluation-for-occupational-cancer-in-korea
#16
REVIEW
Hyoung-Ryoul Kim, Boowook Kim, Bum Seak Jo, Ji-Won Lee
Crystalline silica has been classified as a definite carcinogen (Group 1) causing lung cancer by the International Agency for Research on Cancer (IARC). In Korea, crystalline silica has been the most common causal agent for workers to apply to the Korea Workers' Compensation and Welfare Service (KWCWS). We used KWCWS data to evaluate workers' crystalline silica exposure levels according to their occupations and industries, and reviewed research papers describing the dose-response relationship between cumulative exposure levels and lung cancer incidence...
2018: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29422043/respiratory-health-effects-of-exposure-to-low-levels-of-airborne-endotoxin-a-systematic-review
#17
REVIEW
Azadèh Farokhi, Dick Heederik, Lidwien A M Smit
BACKGROUND: Elevated endotoxin levels have been measured in ambient air around livestock farms, which is a cause of concern for neighbouring residents. There is clear evidence that occupational exposure to high concentrations of airborne endotoxin causes respiratory inflammation, respiratory symptoms and lung function decline. However, health effects of exposure to low levels of endotoxin are less well described. The aim of this systematic review is to summarize published associations between exposure to relatively low levels of airborne endotoxin and respiratory health endpoints...
February 8, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29417838/lung-cancer-a-brief-review-of-epidemiology-and-screening
#18
Cláudia Gouvinhas, Ramon Andrade De Mello, Daniela Oliveira, José Manuel Castro-Lopes, Pedro Castelo-Branco, Ricardo Sales Dos Santos, Venceslau Hespanhol, Daniel Humberto Pozza
The global burden of lung cancer has been increasing over the past years, and is still a major threat to public health worldwide, leading to disabilities and premature mortality. Despite multifactorial cause, smoking remains as the major etiological factor, followed by occupational exposure to carcinogens, genetic predisposition and other concomitant diseases. In order to reduce the individual and social burden due to the direct and indirect costs related to the lung cancer treatment, accurate methods of screening are needed...
February 8, 2018: Future Oncology
https://www.readbyqxmd.com/read/29413507/respiratory-effects-of-trichloroethylene
#19
REVIEW
Orianne Dumas, Thomas Despreaux, Frédéric Perros, Edmund Lau, Pascal Andujar, Marc Humbert, David Montani, Alexis Descatha
Trichloroethylene (TCE) is a chlorinated solvent that has been used widely around the world in the twentieth century for metal degreasing and dry cleaning. Although TCE displays general toxicity and is classified as a human carcinogen, the association between TCE exposure and respiratory disorders are conflicting. In this review we aimed to systematically evaluate the current evidence for the respiratory effects of TCE exposure and the implications for the practicing clinician. There is limited evidence of an increased risk of lung cancer associated with TCE exposure based on animal and human data...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29400899/mild-cough-%C3%A2-wheezing-%C3%A2-loud-heart-sounds-%C3%A2-dx
#20
Arneh Babakhani, Robert N Clapp, William B Warner
A 25-year-old man, who was an active duty US Navy sailor, went to his ship's medical department complaining of a mild cough that he'd had for 2 days. He denied having any fevers, chills, night sweats, angina, or dyspnea. He said he hadn't experienced any exertional fatigue or difficulty completing the rigorous physical tasks of his occupation as an engineman on the ship. The patient had no medical or surgical history of significance, and he wasn't taking any medications or supplements. On exam, he was not in acute distress and his vital signs were within normal limits...
February 2018: Journal of Family Practice
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