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Occupational Lung

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https://www.readbyqxmd.com/read/28446737/pleural-mesothelioma-in-doll-manufacture-possible-asbestos-exposure
#1
Pietro Gino Barbieri, Anna Benedetta Somigliana, Sandra Lombardi, Roberto Festa, Roberto Girelli, Michela Sarnico
BACKGROUND: The occurrence of malignant mesothelioma is almost always causally associated to asbestos exposure but, considering women occurrences, this association is often difficult to demonstrate and consequently the asbestos exposure is defined as 'unknown'. OBJECTIVES: To describe the working activity and to give occupational asbestos exposure probability estimation related to an uncommon and poorly investigated productive sector: doll manufacture. METHODS: From the Province of Brescia Mesothelioma Registry, established in 1993 on population-based criteria, we have extracted the certified mesothelioma diagnosis cases, related to patients who were employed for some time in doll manufacture...
April 21, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28444932/the-association-of-lamb1-polymorphism-and-expression-changes-with-the-risk-of-coal-workers-pneumoconiosis
#2
Xiaoming Ji, Baiqun Wu, Ruhui Han, Jingjin Yang, Esther Ayaaba, Ting Wang, Lei Han, Chunhui Ni
BACKGROUND: Pneumoconiosis is a serious occupational disease worldwide, which is characterized by irreversible and diffuse lung fibrotic lesions. Laminin beta 1(LAMB1) is widely expressed in tissues and it is crucial for both lung morphogenesis and physiological function. In this study, we explored the association between LAMB1 rs4320486 and risk of pneumoconiosis in a Chinese population, as well as its mechanisms. METHODS: In this case-control study, 600 CWP patients and 605 controls were genotyped for the LAMB1 rs4320486 polymorphism using TaqMan methods...
April 26, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28443582/high-resolution-computed-tomography-and-pulmonary-function-findings-of-occupational-arsenic-exposure-in-workers
#3
Recai Ergün, Ender Evcik, Dilek Ergün, Begüm Ergan, Esin Özkan, Özge Gündüz
BACKGROUND: The number of studies where non-malignant pulmonary diseases are evaluated after occupational arsenic exposure are very few. AIMS: The aim of this study is to show the effects of occupational arsenic exposure on the lung by high-resolution computed tomography (HRCT) and pulmonary function tests (PFTs). STUDY DESIGN: Retrospective cross-sectional study. METHODS: In this study 256 workers who were suspected respiratory occupational arsenic exposure are included, having average age 32...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28440535/socioeconomic-status-and-its-relationship-to-chronic-respiratory-disease
#4
Sonu Sahni, Ankoor Talwar, Sameer Khanijo, Arunabh Talwar
Socioeconomic status (SES) is defined as an individual's social or economic standing, and is a measure of an individual's or family's social or economic position or rank in a social group. It is a composite of several measures including income, education, occupation, location of residence or housing. Studies have found a lower SES has been linked to disproportionate access to health care in many diseases. There is emerging data in pulmonary diseases such as COPD, asthma, cystic fibrosis, pulmonary hypertension and other chronic respiratory conditions that allude to a similar observation noted in other chronic diseases...
2017: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/28439933/effect-of-anti-ige-in-occupational-asthma-caused-by-exposure-to-low-molecular-weight-agents
#5
M Ollé-Monge, M J Cruz, S Gomez-Ollés, I Ojanguren, J Vanoirbeek, X Muñoz
BACKGROUND: The role of immunoglobulin (Ig)-E in occupational asthma (OA) due to low molecular weight (LMW) agents is not well established compared to classical atopic asthma. In the present study we evaluate whether anti-IgE monoclonal antibody (mAb) has an effect in a mouse model of OA, using persulfate salts. METHODS: On days 1 and 8, BALB/C mice were dermally sensitized with 5% ammonium persulfate (AP) or dimethyl sulfoxide (DMSO). On days 15, 18 and 21 animals were injected intraperitoneally with anti-IgE mAb or PBS 6 hours before challenge with AP or saline...
April 25, 2017: Allergy
https://www.readbyqxmd.com/read/28434983/future-perspective-of-butter-flavorings-related-occupational-lung-disease
#6
EDITORIAL
Kendall B Wallace
No abstract text is available yet for this article.
April 20, 2017: Toxicology
https://www.readbyqxmd.com/read/28433707/genetic-susceptibility-to-toxicologic-lung-responses-among-inbred-mouse-strains-following-exposure-to-carbon-nanotubes-and-profiling-of-underlying-gene-networks
#7
Evan A Frank, Vinicius S Carreira, Kumar Shanmukhappa, Mario Medvedovic, Daniel R Prows, Jagjit S Yadav
The risk of human exposure to fiber nanoparticles has risen in recent years due to increases in the manufacture and utilization of carbon nanotubes (CNTs). CNTs are present as airborne particulates in occupational settings and their hazard potential has been demonstrated in experimental lung exposure studies using inbred mouse strains. However, it is not known whether different inbred strains differ in lung responses to CNTs by virtue of their genetics. In this work, common inbred strains (BALB/c, C57Bl/6, DBA/2, and C3H/He) were exposed to CNTs via oropharyngeal aspiration and lung histology and bronchoalveolar lavage (BAL) samples were evaluated over 28days with the objective of evaluating sensitivity/resistance among strains...
April 19, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28432368/indoor-radon-in-micro-geological-setting-of-an-indigenous-community-in-canada-a-pilot-study-for-hazard-identification
#8
Atanu Sarkar, Derek Hc Wilton, Erica Fitzgerald
BACKGROUND: Radon is the second leading cause of lung cancer after smoking. In Canada, the health authorities have no access to comprehensive profile of the communities built over uranium-rich micro-geological settings. The present indoor radon monitoring guideline is unable to provide an accurate identification of health hazards due to discounting several parameters of housing characteristics. OBJECTIVE: To explore indoor radon levels in a micro-geological setting known for high uranium in bedrock and to develop a theoretical model for a revised radon testing protocol...
April 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28431523/the-utility-of-electron-microscopy-in-detecting-asbestos-fibers-and-particles-in-balf-in-diffuse-lung-diseases
#9
Takashi Kido, Yasuo Morimoto, Kazuhiro Yatera, Hiroshi Ishimoto, Takaaki Ogoshi, Keishi Oda, Kei Yamasaki, Toshinori Kawanami, Shohei Shimajiri, Hiroshi Mukae
BACKGROUND: In patients with diffuse lung diseases, differentiating occupational lung diseases from other diseases is clinically important. However, the value of assessing asbestos and particles in bronchoalveolar lavage fluid (BALF) in diffuse lung diseases by electron microscopy (EM) remains unclear. We evaluated the utility of EM in detecting asbestos fibers and particles in patients with diffuse lung diseases. METHODS: The BALF specimens of 107 patients with diffuse lung diseases were evaluated...
April 21, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28429752/lncrna-hit-promotes-cell-proliferation-of-non-small-cell-lung-cancer-by-association-with-e2f1
#10
L Yu, F Fang, S Lu, X Li, Y Yang, Z Wang
Lung cancer is the leading cause of cancer-related death around the world. Long noncoding RNA (lncRNA) has pivotal roles in cancer occurrence and development. However, only a few lncRNAs have been functionally characterized. In the present study, we investigated the effects of lncRNA-HIT (HOXA transcript induced by TGFβ) expression on non-small cell lung cancer (NSCLC) cell phenotype with the gain-of-function and loss-of-function assays. We found that ectopic expression or knockdown of lncRNA-HIT markedly increased or decreased NSCLC cell proliferation, respectively...
April 21, 2017: Cancer Gene Therapy
https://www.readbyqxmd.com/read/28428789/il-10-producing-b-cells-regulate-t-helper-cell-immune-responses-during-1-3-%C3%AE-glucan-induced-lung-inflammation
#11
Fangwei Liu, Xiaowei Lu, Wujing Dai, Yiping Lu, Chao Li, Sitong Du, Ying Chen, Dong Weng, Jie Chen
With the rapid development of industry and farm, fungi contamination widely exists in occupational environment. Inhalation of fungi-contaminated organic dust results in hypersensitivity pneumonitis. 1,3-β-Glucan is a major cell wall component of fungus and is considered as a biomarker of fungi exposure. Current studies showed that 1,3-β-glucan exposure induced lung inflammation, which involved uncontrolled T helper (Th) cell immune responses, such as Th1, Th2, Th17, and regulatory T cell (Treg). A recently identified IL-10-producing B cells (B10) was reported in regulating immune homeostasis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28427549/lung-diseases-associated-with-hydrocarbon-exposure
#12
REVIEW
Stephen J Connellan
The human race has been exposed to the potential toxicity of hydrocarbons, whether by the inhaled or ingested route, for thousands of years and the consequent inflammatory reaction in the lungs depends on the degree of exposure, volatility and viscosity of the particular hydrocarbon in question. Heating, lighting, transportation, industry and nature all provide the potential for both inhalation and/or ingestion of hydrocarbons. Some forms, such as those related to petroleum products, e.g. diesel exhaust particles (DEP) and polycyclic aromatic hydrocarbons (PAH) have been shown to cause both malignant and non-malignant respiratory diseases...
May 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28425826/lung-function-and-prevalence-of-respiratory-symptoms-in-norwegian-crab-processing-workers
#13
Marte R Thomassen, Lisbeth Aasmoe, Berit E Bang, Tonje Braaten
BACKGROUND: Seafood processing workers have an increased risk of developing occupational asthma. This has not been studied among Norwegian crab processing workers, nor has the respiratory health of exposed workers been compared to a control group. OBJECTIVES: Assessing the impact of working in the crab processing industry on workers' respiratory health. DESIGN: A cross-sectional study of the respiratory health in two types of crab processing workers compared to a control group...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/28425640/profiling-of-the-silica-induced-molecular-events-in-lung-epithelial-cells-using-the-rna-seq-approach
#14
Judy Y W Chan, Joseph C C Tsui, Patrick T W Law, Winnie K W So, Doris Y P Leung, Michael M K Sham, Stephen K W Tsui, Carmen W H Chan
Silicosis is a prolonged, irreversible and incurable occupational disease, and there is a significant number of newly diagnosed cases every year in Hong Kong. Due to the long latency of the disease, the diagnosis can be missed until detailed clinical examination at a later stage. For a better control of this deadly disease, detailing the pro-inflammatory and fibrotic events in the macrophage would be instrumental in understanding the pathogenesis of the disease and essential for the significant biomarkers discovery...
April 20, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28418689/an-official-american-thoracic-society-workshop-report-chemical-inhalational-disasters-biology-of-lung-injury-development-of-novel-therapeutics-and-medical-preparedness
#15
Eleanor M Summerhill, Gary W Hoyle, Sven-Eric Jordt, Bronwen J Jugg, James G Martin, Sadis Matalon, Steven E Patterson, David J Prezant, Alfred M Sciuto, Erik R Svendsen, Carl W White, Livia A Veress
This report is based upon the proceedings from the Inhalational Lung Injury Workshop jointly sponsored by the American Thoracic Society (ATS) and the National Institute of Health (NIH)/National Institute of Neurologic Disorders and Stroke (NINDS) Countermeasures Against Chemical Threats (CounterACT) program on May 21, 2013 in Philadelphia, PA. The CounterACT program facilitates research leading to the development of new and improved medical countermeasures for chemical threat agents. The workshop was initiated by the Terrorism and Inhalational Disasters (TID) Section of the Environmental, Occupational, and Population Health Assembly (EOPH) of the ATS...
April 18, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28417309/effects-of-nano-zinc-on-biochemical-parameters-in-cadmium-exposed-rats
#16
Marzie Hejazy, Mohammad Kazem Koohi
Cadmium (Cd) is a toxic environmental and occupational pollutant with reported toxic effects on the kidneys, liver, lungs, bones, and the immunity system. Based on its physicochemical similarity to cadmium, zinc (Zn) shows protective effects against cadmium toxicity and cadmium accumulation in the body. Nano-zinc and nano-zinc oxide (ZnO), recently used in foods and pharmaceutical products, can release a great amount of Zn(2+) in their environment. This research was carried out to investigate the more potent properties of the metal zinc among sub-acute cadmium intoxicated rats...
April 17, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28416642/estimating-the-burden-of-occupational-cancer-assessing-bias-and-uncertainty
#17
Sally Hutchings, Lesley Rushton
BACKGROUND AND OBJECTIVES: We aimed to estimate credibility intervals for the British occupational cancer burden to account for bias uncertainty, using a method adapted from Greenland's Monte Carlo sensitivity analysis. METHODS: The attributable fraction (AF) methodology used for our cancer burden estimates requires risk estimates and population proportions exposed for each agent/cancer pair. Sources of bias operating on AF estimator components include non-portability of risk estimates, inadequate models, inaccurate data including unknown cancer latency and employment turnover and compromises in using the available estimators...
April 17, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28415992/women-epidemiology-lung-cancer-welca-study-reproductive-hormonal-occupational-risk-factors-and-biobank
#18
MULTICENTER STUDY
Isabelle Stücker, Diane Martin, Monica Neri, Pierre Laurent-Puig, Hélène Blons, Martine Antoine, Anne Guiochon-Mantel, Sylvie Brailly-Tabard, Marianne Canonico, Marie Wislez, Jean Trédaniel
BACKGROUND: Lung cancer aetiology and clinical aspects have been mainly studied in men, although specific risk factors probably exist in women. Here we present the rationale, design and organization of the WELCA study (Women Epidemiology Lung CAncer) that has been launched to investigate lung cancer in women, focusing particularly on hormonal and occupational factors. METHODS/DESIGN: WELCA is a population based case-control study and planned to recruit 1000 cases and 1000 controls in three years, based on study power calculation...
April 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28413169/respiratory-effects-of-simultaneous-exposure-to-respirable-crystalline-silica-dust-formaldehyde-and-triethylamine-of-a-group-of-foundry-workers
#19
Fatemeh Zarei, Mansour Rezazadeh Azari, Sousan Salehpour, Soheila Khodakarim, Leila Omidi, Elahe Tavakol
BACKGROUND: Foundry workers are occupationally exposed to hazardous substances such as silica dusts and toxic gases. The aim of this study was to examine the effects of simultaneous exposure to complex mixtures of silica dust, formaldehyde, and triethylamine on lung function parameters. STUDY DESIGN: A cross-sectional study. METHODS: This study was conducted on 55 male workers of core making unit of a foundry plant (the case group) and 55 workers in a food industry were enrolled as a control group in 2015...
March 4, 2017: Journal of Research in Health Sciences
https://www.readbyqxmd.com/read/28409224/occupational-exposure-to-respirable-crystalline-silica-and-chronic-non-malignant-renal-disease-systematic-review-and-meta-analysis
#20
REVIEW
Matthias Möhner, Anne Pohrt, Johannes Gellissen
BACKGROUND: While occupational exposure to respirable silica is known to lead to lung disease, most notably silicosis, its association with chronic kidney disease is unclear. OBJECTIVES: This review explores the association between occupational exposure to respirable silica and chronic non-malignant renal disease such as glomerulonephritis. The evidence has been collected and compiled. Possible sources of bias are thoroughly discussed. METHODS: Cohort studies with silica exposure and case-control studies of renal disease were searched in PubMed until January 2015...
April 13, 2017: International Archives of Occupational and Environmental Health
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