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JOURNAL ARTICLE
Jyoti Sharma, Surya V S Deo, Sunil Kumar, Sandeep Bhoriwal, Madhabananda Kar, Adarsh W Barwad, Sanjay Thulkar, Sameer Bakhshi, D N Sharma
BACKGROUND: Adult soft tissue sarcomas (STS) are rare and diverse. Current management is based on limited literature from the West. Therefore, data from different geographical regions is required, including the low-middle-income countries. This is our experience managing adult sarcomas in the tertiary cancer center of North India. MATERIALS AND METHODS: This is a retrospective analysis of the structured sarcoma database of patients treated in the surgical oncology department between 1992 and 2020...
February 21, 2024: Asia-Pacific Journal of Clinical Oncology
#22
JOURNAL ARTICLE
Erik A Williams, Isabella Vegas, Fardous F El-Senduny, Jessica Zhang, Douglas A Mata, Matthew C Hiemenz, Sarah R Hughes, Brianna C Sa, Garrett P Kraft, Nicole Gorbatov, Kathleen Foley-Peres, Edward Z Sanchez, Clara Milikowski, Kevin Jon Williams, Jeffrey S Ross, Razelle Kurzrock, Elizabeth A Montgomery, David B Lombard, Surinder Kumar
Myxofibrosarcoma (MFS) is a common soft tissue sarcoma of the elderly that typically shows low tumor mutational burden, with mutations in TP53 and in genes associated with cell cycle checkpoints (RB1, CDKN2A). Unfortunately, no alterations or markers specific to MFS have been identified and, as a consequence, there are no effective targeted therapies. The receptor tyrosine kinase AXL, which drives cellular proliferation, is targetable by new antibody-based therapeutics. Expression of AXL messenger RNA is elevated in a variety of sarcoma types, with the highest levels reported in MFS, but the pathogenic significance of this finding remains unknown...
February 19, 2024: American Journal of Surgical Pathology
#23
JOURNAL ARTICLE
Christina L Roland, Elise F Nassif Haddad, Emily Z Keung, Wei-Lien Wang, Alexander J Lazar, Heather Lin, Manoj Chelvanambi, Edwin R Parra, Khalida Wani, B Ashleigh Guadagnolo, Andrew J Bishop, Elizabeth M Burton, Kelly K Hunt, Keila E Torres, Barry W Feig, Christopher P Scally, Valerae O Lewis, Justin E Bird, Ravin Ratan, Dejka Araujo, M Alexandra Zarzour, Shreyaskumar Patel, Robert Benjamin, Anthony P Conley, J Andrew Livingston, Vinod Ravi, Hussein A Tawbi, Patrick P Lin, Bryan S Moon, Robert L Satcher, Bilal Mujtaba, Russell G Witt, Raymond S Traweek, Brandon Cope, Rossana Lazcano, Chia-Chin Wu, Xiao Zhou, Mohammad M Mohammad, Randy A Chu, Jianhua Zhang, Ashish Damania, Pranoti Sahasrabhojane, Taylor Tate, Kate Callahan, Sa Nguyen, Davis Ingram, Rohini Morey, Shadarra Crosby, Grace Mathew, Sheila Duncan, Cibelle F Lima, Jean-Yves Blay, Wolf Herman Fridman, Kenna Shaw, Ignacio Wistuba, Andrew Futreal, Nadim Ajami, Jennifer A Wargo, Neeta Somaiah
Based on the demonstrated clinical activity of immune-checkpoint blockade (ICB) in advanced dedifferentiated liposarcoma (DDLPS) and undifferentiated pleomorphic sarcoma (UPS), we conducted a randomized, non-comparative phase 2 trial ( NCT03307616 ) of neoadjuvant nivolumab or nivolumab/ipilimumab in patients with resectable retroperitoneal DDLPS (n = 17) and extremity/truncal UPS (+ concurrent nivolumab/radiation therapy; n = 10). The primary end point of pathologic response (percent hyalinization) was a median of 8...
February 13, 2024: Nature Cancer
#24
Xuyang Zhang, Yan Sun
Undifferentiated pleomorphic sarcoma is an extremely rare malignant thyroid tumor. Thyroid sarcoma differs from common malignant thyroid tumors, such as thyroid follicular cell carcinoma. It is usually highly malignant, progresses rapidly, and is prone to remote metastasis. Currently, there is no standard protocol for the treatment of thyroid sarcomas, and most treatment effects are unsatisfactory. Argon-helium cryoablation is an important method of local treatment that is widely used in patients with unresectable advanced tumors...
November 2023: J Interv Med
#25
Makishi Nakamura, Kazuaki Yamanaka, Taigo Kato, Koji Hatano, Yoichi Kakuta, Atsunari Kawashima, Shinichiro Fukuhara, Norio Nonomura
A 52-year-old male had pain in the right back and right hypochondrium, and an abdominal CT scan revealed a 49-mm tumor in the right upper perirenal space. Additional MRI and PET-CT suggested that the tumor may be a primary adrenal carcinoma and could invade the liver and diaphragmatic leg. The tumor was completely removed by laparotomy and histopathologically diagnosed as retroperitoneal primary undifferentiated pleomorphic sarcoma. The patient has remained recurrence-free for 1.5 years after the surgery.
March 2024: Urology Case Reports
#26
JOURNAL ARTICLE
W N Wang, X T Liu, Y M Liang
Objective: To investigate the clinicopathological characteristics of SMARCA4-deficient thoracic undifferentiated tumors, and the diagnostic value of the cells in serous effusion. Methods: Eleven cases of SMARCA4-deficient tumor were collected from the Affiliated Hospital of Hebei University, China from January 2018 to July 2023, which were diagnosed using cell block of serous effusion. The clinical, histopathological, immunohistochemical and molecular genetic features were reviewed, along with related literature...
February 8, 2024: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
#27
REVIEW
Jasmine S Saleh, Carli P Whittington, Scott C Bresler, Rajiv M Patel
Pleomorphic dermal sarcoma (PDS) is a rare cutaneous/subcutaneous neoplasm of purported mesenchymal differentiation that exists along a clinicopathologic spectrum with atypical fibroxanthoma (AFX). While PDS and AFX share histopathologic and immunohistochemical features, PDS exhibits deeper tissue invasion and has a higher rate of metastasis and local recurrence than AFX. Given its aggressive clinical course, early recognition and clinical management of PDS are essential for optimizing patient outcomes. This review aims to provide a brief overview of the clinicopathologic and molecular features, prognosis, and treatment of PDS...
March 2024: Surgical Pathology Clinics
#28
JOURNAL ARTICLE
Suyeon Kim, Hyunsik Bae, Hyun-Soo Kim
Dedifferentiation is a very rare phenomenon in uterine leiomyosarcoma (LMS). The aim of this study was to comprehensively analyze the clinicopathological characteristics of uterine dedifferentiated LMS (DDLMS). We reviewed electronic medical records and pathology slides from five patients with uterine DDLMS and performed immunostaining. The mean age of the patients was 56 years. Two patients presented with abdominal discomfort, while in three cases the uterine tumors were detected on routine medical examination...
January 10, 2024: Diagnostics
#29
JOURNAL ARTICLE
Candace L Haddox, Michael J Nathenson, Emanuele Mazzola, Jia-Ren Lin, Joanna Baginska, Allison Nau, Jason L Weirather, Edwin Choy, Adrian Marino-Enriquez, Jeffrey A Morgan, Gregory M Cote, Priscilla Merriam, Andrew J Wagner, Peter K Sorger, Sandro Santagata, Suzanne George
PURPOSE: Eribulin modulates the tumor-immune microenvironment via cGAS-STING signaling in preclinical models. This non-randomized phase II trial evaluated the combination of eribulin and pembrolizumab in patients with soft tissue sarcomas (STS). PATIENTS AND METHODS: Patients enrolled in one of three cohorts: leiomyosarcoma (LMS), liposarcomas (LPS), or other STS that may benefit from PD-1 inhibitors, including undifferentiated pleomorphic sarcoma (UPS). Eribulin was administered at 1...
January 18, 2024: Clinical Cancer Research
#30
REVIEW
Valentina Sala, Giuliana Di Simone, Chiara Lubrano, Aida Quarenghi, Roberta Simona Rossi, Manuela Nebuloni, Irene Cetin
Soft tissue sarcomas accounts for 1-2% of adult malignancies. Undifferentiated pleomorphic sarcoma (UPS) is a rare subtype that lack immunohistochemical markers for a specific definition. About 18% of sarcomas are at a locally advanced stage, often requiring several cycles of chemotherapy and radiotherapy, in addition to surgery. For a young woman, this can mean delaying pregnancies with a high risk of therapy-induced ovarian damage. For this reason, proper counseling on fertility preservation plays a key role...
March 2024: European journal of obstetrics & gynecology and reproductive biology: X
#31
JOURNAL ARTICLE
Sintawat Wangsiricharoen, Davis R Ingram, Rohini R Morey, Khalida Wani, Alexander J Lazar, Wei-Lien Wang
Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors that express smooth muscle and melanocytic makers. Diagnosis of PEComas can be challenging due to focal or lost expression of traditional immunohistochemical markers, limited availability of molecular testing, and morphological overlap with much more common smooth muscle tumors. This study evaluates the use of glycoprotein nonmetastatic melanoma protein B (GPNMB) immunohistochemical staining as a surrogate marker for TSC1/2/MTOR alteration or TFE3 rearrangement to differentiate PEComas from other mesenchymal tumors...
January 12, 2024: Modern Pathology
#32
JOURNAL ARTICLE
Charles Gusho, Rachel Phillips, James Cook, Andrea Evenski
BACKGROUND: Negative wound pressure therapy (NWPT) may reduce the wound complication (WC) risk in soft tissue sarcoma (STS) and is often utilized for large and/or irradiated wounds, extensive dissections, or wounds at risk of impaired drainage. However, data on WCs after NWPT in STS are lacking. This study systematically reviewed the available literature on NWPT in STS. METHODS: A query of the Cochrane Central Register of Controlled Trials (1976-2022), Cochrane Database of Systematic Reviews, MEDLINE (1946-2022), Scopus, and PubMed (1964-2022) was performed...
December 2023: Iowa Orthopaedic Journal
#33
REVIEW
M Anastasiou, A Kyriazoglou, I Kotsantis, P Economopoulou, M Kyrkasiadou, A Giannopoulou, A Kosmidou, D Smerdi, M Moutafi, N Gavrielatou, A Psyrri
Sarcomas are tumors that originate from mesenchymal cells. The variety of sarcomas' response to chemotherapy and the wide range of prognosis reflect their heterogeneity. In order to improve the rates of response, the research has been orientated toward other forms of therapy, such as targeted therapies and immunotherapy or toward combinations of them. Immune checkpoint inhibitors (ICIs) have been the highlight of immunotherapy in the last decade. Although ICIs are already included in the guidelines of different malignancies, their clinical benefit in sarcomas is still under study...
December 2023: Immunooncol Technol
#34
Yusuke Utsunomiya, Kanae K Miyake, Satsuki Fukushima, Hideyuki Kinoshita, Yoshihiko Ikeda, Manabu Matsumoto, Kinta Hatakeyama, Takao Kato, Masahide Kawatou, Kenji Minatoya, Yuji Nakamoto
UNLABELLED: Primary cardiac sarcomas are rare and sometimes difficult to discern from benign tumors and intracardiac thrombi. We describe the ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), and 18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography (PET)/CT findings in a case of left atrial undifferentiated pleomorphic sarcoma with osteosarcomatous differentiation, presenting with severe mitral regurgitation and pulmonary hypertension. The tumor presented as a broad-base mass protruding into the cardiac lumen, accompanied by punctate calcification-like high attenuation on CT...
January 2024: Journal of Cardiology Cases
#35
JOURNAL ARTICLE
Elvis Duran Sierra, Raul Valenzuela, Mathew A Canjirathinkal, Colleen M Costelloe, Heerod Moradi, John E Madewell, William A Murphy, Behrang Amini
PURPOSE: Limitations from commercial software applications prevent the implementation of a robust and cost-efficient high-throughput cancer imaging radiomic feature extraction and perfusion analysis workflow. This study aimed to develop and validate a cancer research computational solution using open-source software for vendor- and sequence-neutral high-throughput image processing and feature extraction. METHODS: The Cancer Radiomic and Perfusion Imaging (CARPI) automated framework is a Python-based software application that is vendor- and sequence-neutral...
January 2024: JCO Clinical Cancer Informatics
#36
Ala S Abu-Dayeh, Khaled A Murshed, Adham Ammar, Mahir Petkar
Primary laryngeal sarcomas are rare. Their nomenclature and classification are similar to soft tissue counterparts; however, there are notable differences between clinical presentation, behavior, treatment, and follow-up. There is sparse information regarding the clinical features, biologic behavior, and treatment modalities of laryngeal sarcomas. To increase our understanding about these tumors, we describe herein an additional series of four cases of different pathologic types of laryngeal sarcomas, including low-grade chondrosarcoma, leiomyosarcoma, well-differentiated liposarcoma, and undifferentiated pleomorphic sarcoma...
October 2023: Avicenna Journal of Medicine
#37
JOURNAL ARTICLE
Hsin-Yi Chang, Josephine Dermawan, Aarti Sharma, Brendan Dickson, Gulisa Turashvili, Dianne Torrence, Marisa Nucci, Sarah Chiang, Esther Oliva, Martina Kirchner, Albrecht Stenzinger, Gunhild Mechtersheimer, Cristina Antonescu
RAD51B-rearranged sarcomas are rare neoplasms that exhibit a heterogeneous morphology. To date, 6 cases have been reported, all involving the uterus, including 4 perivascular epithelioid cell tumors (PEComas) and 2 leiomyosarcomas (LMS). In this study, we describe the morphologic, immunohistochemical, and molecular features of 8 additional sarcomas with RAD51B rearrangement, including the first extrauterine example. All patients were women with a median age of 57 years at presentation. Seven tumors originated in the uterus, and one in the lower extremity soft tissue, with a median tumor size of 12 cm...
February 2024: Modern Pathology
#38
JOURNAL ARTICLE
Savaş Yıldırım, Mert Çiftdemir, Fethi Emre Ustabaşıoğlu, Funda Üstün, Ufuk Usta
OBJECTIVES: The aim of this study was to evaluate the factors affecting local recurrence and survival in patients with soft-tissue sarcomas located in the thigh. PATIENTS AND METHODS: This retrospective cross-sectional study evaluated 41 soft tissue sarcoma patients (21 males, 20 females; mean age: 57.9±13.7 years; range, 18 to 90 years) with thigh involvement between January 2010 and December 2020. All surgical intervention was performed by one surgeon with an experience of 15 years in orthopedic oncologic surgery...
January 1, 2024: Joint diseases and related surgery
#39
JOURNAL ARTICLE
Cade Bennett, Sandeep Bharadwaj, Andrew Arndt, Akhil Chawla
BACKGROUND: Undifferentiated pleomorphic sarcoma (UPS) accounts for approximately 15% of all softtissue sarcoma (STS) cases and have a 5-year survival prognosis of around 60%. Due to its complexity, tumors are often identified by clinical and pathological exclusion. UPS is commonly found in the extremities, so finding them in the trunk and chest wall is rare. The primary objectives of this systematic review are: (I) identifying patient characteristics with lesion; (II) compiling patient outcomes following surgery; (III) identifying best therapy modalities; (IV) characterizing reported lesion histology; (V) assessing current surgical recommendations for resection; (VI) classifying lesions and their association with radiation...
November 28, 2023: Chinese Clinical Oncology
#40
REVIEW
Maria L Inchaustegui, Kelly Kon-Liao, Kim Ruiz-Arellanos, George Aquilino E Silva, Marcos R Gonzalez, Juan Pretell-Mazzini
INTRODUCTION: Radiation-induced soft tissue sarcomas (RISs) are rare secondary malignancies with a dire prognosis. The literature on the management of these tumors remains scarce due to their low incidence. Our systematic review sought to assess the treatment alternatives and outcomes of patients with RIS. METHODS: A systematic review was conducted following the PRISMA guidelines. Our study was registered in PROSPERO (ID: CRD42023438415). Quality assessment was performed using the STROBE checklist...
November 25, 2023: Cancers
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