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undifferentiated pleomorphic sarcoma

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https://www.readbyqxmd.com/read/27900663/mir-152-down-regulation-is-associated-with-met-up-regulation-in-leiomyosarcoma-and-undifferentiated-pleomorphic-sarcoma
#1
Laura Pazzaglia, Chiara Novello, Amalia Conti, Serena Pollino, Piero Picci, Maria Serena Benassi
PURPOSE: Highly aggressive adult soft tissue sarcomas (STS), i.e., leiomyosarcomas (LMS) and undifferentiated pleomorphic sarcomas (UPS), present complex genomic anomalies and overall 5-year survival rates of 20 to 40%. Here, we aimed to identify new biomarkers that may be employed to improve the treatment of non-translocation STS patients. We validated 12 miRNAs implicated in tumor development using primary STS samples and selected miR-152 for further analysis in STS-derived cell lines...
November 29, 2016: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/27873216/prognostic-metabolite-biomarkers-for-soft-tissue-sarcomas-discovered-by-mass-spectrometry-imaging
#2
Sha Lou, Benjamin Balluff, Arjen H G Cleven, Judith V M G Bovée, Liam A McDonnell
Metabolites can be an important read-out of disease. The identification and validation of biomarkers in the cancer metabolome that can stratify high-risk patients is one of the main current research aspects. Mass spectrometry has become the technique of choice for metabolomics studies, and mass spectrometry imaging (MSI) enables their visualization in patient tissues. In this study, we used MSI to identify prognostic metabolite biomarkers in high grade sarcomas; 33 high grade sarcoma patients, comprising osteosarcoma, leiomyosarcoma, myxofibrosarcoma, and undifferentiated pleomorphic sarcoma were analyzed...
November 21, 2016: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/27826764/clinical-features-of-soft-tissue-sarcoma-presenting-intra-tumour-haematoma-case-series-and-review-of-the-literature
#3
Manabu Hoshi, Naoto Oebisu, Makoto Ieguchi, Yoshitaka Ban, Masatsugu Takami, Hiroaki Nakamura
INTRODUCTION: Intra-tumour haematoma is an uncommon clinical presentation in malignant soft tissue tumours. This study aimed to highlight the clinical features of patients with soft tissue sarcomas with intra-tumour haematoma. METHODS: The patient group was composed of eight men and one woman aged between 29 and 83 years (mean 44.0 ± 20.8). The average follow-up was 29.8 months. Clinical information, including clinical features, radiological information and treatment course, was retrospectively investigated...
November 8, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27817254/cytohistological-and-immunohistochemical-characteristics-of-spindle-shaped-mesenchymal-neoplasms-occurring-in-the-gastrointestinal-tract
#4
Antonio Ieni, Valeria Barresi, Luca Reggiani Bonetti, Giovanni Branca, Rosario Alberto Caruso, Giovanni Tuccari
The purpose of the present review is to analyze the cytohistological and immunohistochemical characteristics of spindle-shaped mesenchymal gastrointestinal neoplams (MGNs), a group of unusual neoplastic conditions with different biological behavior. These tumors exhibit clinical pictures strictly related to the site of origin and dimensions, even if they appear generally with an intramural localization. This latter point may suggest an useful application of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), mainly followed by the cell-block procedure (CBP) in the differential diagnostic approach...
November 6, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27739400/an-epidemiological-survey-of-tumour-or-tumour-like-conditions-in-the-scapula-and-periscapular-region
#5
Zeeshan Khan, Adam M Gerrish, Robert J Grimer
INTRODUCTION: The scapula is not an uncommon site for bone and soft tissue tumours and can be difficult to delineate on examination. Furthermore, these lesions can be potentially challenging to biopsy due to its close anatomical relationship with important structures. We present an epidemiological survey of all the scapular and periscapular lesions presenting to our institution. METHODOLOGY: This was a retrospective study with data obtained from a prospectively held electronic database over a 30-year period...
2016: SICOT-J
https://www.readbyqxmd.com/read/27733900/high-nuclear-expression-of-proteasome-activator-complex-subunit-1-predicts-poor-survival-in-soft-tissue-leiomyosarcomas
#6
Sha Lou, Arjen H G Cleven, Benjamin Balluff, Marieke de Graaff, Marie Kostine, Inge Briaire-de Bruijn, Liam A McDonnell, Judith V M G Bovée
BACKGROUND: Previous studies on high grade sarcomas using mass spectrometry imaging showed proteasome activator complex subunit 1 (PSME1) to be associated with poor survival in soft tissue sarcoma patients. PSME1 is involved in immunoproteasome assembly for generating tumor antigens presented by MHC class I molecules. In this study, we aimed to validate PSME1 as a prognostic biomarker in an independent and larger series of soft tissue sarcomas by immunohistochemistry. METHODS: Tissue microarrays containing leiomyosarcomas (n = 34), myxofibrosarcomas (n = 14), undifferentiated pleomorphic sarcomas (n = 15), undifferentiated spindle cell sarcomas (n = 4), pleomorphic liposarcomas (n = 4), pleomorphic rhabdomyosarcomas (n = 2), and uterine leiomyomas (n = 7) were analyzed for protein expression of PSME1 using immunohistochemistry...
2016: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/27733375/short-full-dose-adjuvant-chemotherapy-ct-in-high-risk-adult-soft-tissue-sarcomas-sts-long-term-follow-up-of-a-randomized-clinical-trial-from-the-italian-sarcoma-group-and-the-spanish-sarcoma-group
#7
A Gronchi, S Stacchiotti, P Verderio, S Ferrari, J Martin Broto, A Lopez-Pousa, A Llombart-Bosch, A P Dei Tos, P Collini, J Cruz Jurado, A De Paoli, D M Donati, A Poveda, V Quagliuolo, A Comandone, G Grignani, C Morosi, A Messina, R De Sanctis, S Bottelli, E Palassini, P G Casali, Piero Picci
BACKGROUND: To report on long-term results of a phase 3 trial comparing three versus five cycles of adjuvant chemotherapy (CT) with full-dose epirubicin+ifosfamide in high-risk soft tissue sarcomas (STS). METHODS: Patients (pts) were randomized to receive three preoperative cycles of epirubicin 120 mg/m(2) and ifosfamide 9 g/m(2) (Arm A) or to receive the same three preoperative cycles plus two postoperative cycles (Arm B). Radiotherapy could be either delivered in the preoperative or in the postoperative setting...
October 11, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27646893/-significance-of-satb2-in-the-pathologic-diagnosis-of-osteosarcoma
#8
M Li, Y P Cai, K Y Lu, Y Chen, X Zhu, Y Yin, J Tang
Objective: To investigate the role of SATB2 in the pathological diagnosis and differential diagnosis of osteosarcoma. Methods: Immunostaining of SATB2 was performed in 47 cases of osteosarcomas, 5 osteoblastomas, 4 fibrous dysplasias, 5 myositis ossificans, 10 chondroblastomas, 8 chondrosarcomas, 5 Ewing sarcomas, 5 undifferentiated pleomorphic sarcomas, 6 fibrosarcomas and 2 leiomyosarcomas. Results: All osteoblastomas (5/5) and myositis ossificans (5/5), 83.0%(39/47) of osteosarcomas and 2/10 of chondroblastomas showed nuclear immunoreactivity for SATB2...
September 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27639272/lhrh-receptor-expression-in-sarcomas-of-bone-and-soft-tissue
#9
Chenthuran Deivaraju, H Thomas Temple, Norman Block, Philip Robinson, Andrew V Schally
AIM: Luteinizing hormone releasing hormone (LHRH) is a neurohormone, secreted by the hypothalamus, which regulates the secretion of gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the pituitary. LHRH acts by binding to receptors located in the pituitary gland. These receptors (LHRH receptors) have also been found in the cytoplasm of many tumor cells that involve both the reproductive and non-reproductive organs. These receptors have been demonstrated in prostate and breast cancers, endometrial carcinomas, renal cell carcinoma, lymphoma, carcinoma of liver, pancreas and skin...
November 1, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27604552/impact-of-disease-free-status-on-prognosis-in-metastatic-non-small-round-cell-soft-tissue-sarcomas
#10
Hiroshi Urakawa, Eiji Kozawa, Kunihiro Ikuta, Shunsuke Hamada, Naoki Ishiguro, Yoshihiro Nishida
The aim of this study is to examine the impact of disease free (DF) status on the prognosis in patients with metastatic non-small round cell soft tissue sarcoma (STS). We retrospectively reviewed 51 metastatic STS patients who were treated in Nagoya University Hospital from 2005 to 2015. The relation between various clinical factors and overall survival (OS) was analyzed. The log rank test and Cox's proportional hazards test were used to evaluate the differences between groups. p-values of <0.05 were considered to indicate significance...
December 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27600784/-lymph-node-metastasis-of-osteosarcomas
#11
N V Vasil'ev
Lymph node metastasis of osteosarcomas is a rather rare phenomenon; according to different authors, the incidence of lymph node metastasis is 4 to 11%. The detection of lymph node metastases in osteosarcoma is associated with a significant reduction in the 5-year survival of patients and allows its classification as clinical stage IV tumor. The risk factors for lymph node metastases in patients with bone sarcomas are age (≥64 years), gender (female), nosological entity (undifferentiated pleomorphic sarcoma, osteosarcoma, chondrosarcoma), tumor depth (muscle, bone), and the size of primary tumor (>5 сm)...
July 2016: Arkhiv Patologii
https://www.readbyqxmd.com/read/27600780/-a-new-who-classification-of-prostate-tumors
#12
G A Frank, Yu Yu Andreeva, L V Moskvina, G D Efremov, S I Samoilova
The paper reviews the 2016 WHO classification of prostate tumors, notes the alterations made, and describes approaches to the diagnosis of cancer types and grades. It also gives original photomicrographs from the authors' collection. The main alterations were as follows: - The types of prostate adenocarcinoma were added by pleomorphic giant-cell carcinoma; oncocytic (8290/3) and lymphoepithelial (8082/3) carcinomas were excluded. - Grade III prostatic intraepithelial neoplasia (PIN) was substituted for high grade PIN (8148/2)...
July 2016: Arkhiv Patologii
https://www.readbyqxmd.com/read/27594909/an-extremely-rare-case-of-a-high-grade-pleomorphic-cardiac-sarcoma-and-likely-cerebral-metastasis-in-a-young-patient
#13
T G Wilson, P Jenkins, A Hoschtitzky, M McCabe
To date, there have been less than a 100 confirmed case reports of primary cardiac malignant fibrous histiocytomas, a rare form of sarcoma. In this report, we discuss the case of a 15-year-old girl who initially presented with a histiocytic cerebral sarcoma that was treated with aggressive resection and chemotherapy. Three years later, the same patient developed increasing shortness of breath and was found to have a high-grade pleomorphic undifferentiated cardiac sarcoma that likely represents the primary tumour from which the cerebral lesion metastasised...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27563479/undifferentiated-pleomorphic-sarcoma-presenting-as-abdominal-pain-with-a-pulsatile-mass
#14
Arash Moradi, Abolfazl Afsharfard, Khashayar Atqiaee
Malignant fibrous histiocytoma (MFH) is a rare tumor that mostly involves adults aged 50 to 70. The most common anatomic location is the lower extremities. MFH of the retroperitoneum usually manifests late in its course and may be initially mistaken with other more common diagnosis. Here, the authors describe a 60-year-old man that was brought to the emergency department with a chief complaint of periumbilical abdominal pain. Our patient presented with symptoms consistent with a symptomatic aortic aneurysm, but a mass was encountered during surgery...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27560552/establishment-and-molecular-characterisation-of-seven-novel-soft-tissue-sarcoma-cell-lines
#15
Abdulazeez Salawu, Malee Fernando, David Hughes, Malcolm W R Reed, Penella Woll, Claire Greaves, Chris Day, Meshal Alhajimohammed, Karen Sisley
BACKGROUND: Soft-tissue sarcomas (STS) are a diverse group of malignancies that remain a diagnostic and therapeutic challenge. Relatively few reliable cell lines currently exist. Rapidly developing technology for genomic profiling with emerging insights into candidate functional (driver) aberrations raises the need for more models for in vitro functional validation of molecular targets. METHODS: Primary cell culture was performed on STS tumours utilising a differential attachment approach...
October 25, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27556665/practical-issues-for-retroperitoneal-sarcoma
#16
Vicky Pham, Evita Henderson-Jackson, Matthew P Doepker, Jamie T Caracciolo, Ricardo J Gonzalez, Mihaela Druta, Yi Ding, Marilyn M Bui
BACKGROUND: Retroperitoneal sarcoma is rare. Using initial specimens on biopsy, a definitive diagnosis of histological subtypes is ideal but not always achievable. METHODS: A retrospective institutional review was performed for all cases of adult retroperitoneal sarcoma from 1996 to 2015. A review of the literature was also performed related to the distribution of retroperitoneal sarcoma subtypes. A meta-analysis was performed. RESULTS: Liposarcoma is the most common subtype (45%), followed by leiomyosarcoma (21%), not otherwise specified (8%), and undifferentiated pleomorphic sarcoma (6%) by literature review...
July 2016: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/27503444/patterns-of-disease-relapse-in-primary-extremity-soft-tissue-sarcoma
#17
H G Smith, N Memos, J M Thomas, M J F Smith, D C Strauss, A J Hayes
BACKGROUND: Extremity soft-tissue sarcomas comprise a range of distinct histological subtypes. This study aimed to characterize the patterns of disease relapse in patients undergoing resection of primary extremity soft-tissue sarcoma. METHODS: All patients who had resection of primary extremity soft-tissue sarcoma at the Royal Marsden Hospital between January 2004 and January 2014 were identified from an institutional database. RESULTS: In the period examined, 556 patients underwent resection...
October 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27453666/high-grade-undifferentiated-pleomorphic-sarcoma-of-the-pelvis-a-case-report-and-review-of-literature
#18
Slava Agafonoff, Shrikant K Vaidya, Brian DeFade
High-grade spindle cell sarcomas are rare undifferentiated pleomorphic cancers that present a treatment challenge to urological practices, especially when they present in the pelvis. We report a 46-year-old male patient who presented to our urology clinic with urinary retention after having a Foley catheter placed at an outlying facility. A voiding trial was attempted, but the patient failed this trial. This failure resulted in cystoscopy with bilateral retrograde pyelograms, which revealed a compressed bladder due to extrinsic compression...
July 2016: Urology Annals
https://www.readbyqxmd.com/read/27446424/xenograft-models-for-undifferentiated-pleomorphic-sarcoma-not-otherwise-specified-are-essential-for-preclinical-testing-of-therapeutic-agents
#19
Marc Becker, Claudine Graf, Marcus Tonak, Markus P Radsak, Tobias Bopp, Robert Bals, Rainer M Bohle, Matthias Theobald, Pol-Maria Rommens, Dirk Proschek, Thomas C Wehler
Undifferentiated pleomorphic sarcoma not otherwise specified belongs to the heterogeneous group of soft tissue tumors. It is preferentially located in the upper and lower extremities of the body, and surgical resection remains the only curative treatment. Preclinical animal models are crucial to improve the development of novel chemotherapeutic agents for the treatment of undifferentiated pleomorphic sarcoma. However, this approach has been hampered by the lack of reproducible animal models. The present study established two xenograft animal models generated from stable non-clonal cell cultures, and investigated the difference in chemotherapeutic effects on tumor growth between undifferentiated pleomorphic sarcoma in vivo and in vitro...
August 2016: Oncology Letters
https://www.readbyqxmd.com/read/27434038/endosialin-expression-in-soft-tissue-sarcoma-as-a-potential-marker-of-undifferentiated-mesenchymal-cells
#20
Khin Thway, David Robertson, Robin L Jones, Joanna Selfe, Janet Shipley, Cyril Fisher, Clare M Isacke
BACKGROUND: Soft tissue sarcomas are a group of neoplasms with differentiation towards mesenchymal tissue, many of which are aggressive and chemotherapy resistant. Histology and immunoprofiles often overlap with neoplasms of other lineages, and establishing an accurate histopathological diagnosis is crucial for correct management, and therapeutic stratification. The endosialin cell surface glycoprotein is predominantly expressed by stromal fibroblasts and pericytes in epithelial neoplasms; however, tumour cell expression has been reported in small series of sarcomas...
August 9, 2016: British Journal of Cancer
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