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Secondary prevention MI

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https://www.readbyqxmd.com/read/27894896/systematic-review-and-meta-analysis-of-dual-versus-single-antiplatelet-therapy-in-carotid-interventions
#1
REVIEW
M Barkat, S Hajibandeh, S Hajibandeh, F Torella, G A Antoniou
BACKGROUND: The importance of antiplatelet therapy for the management and prevention of ischaemic stroke cannot be overstated. Despite the established guidelines, there is no clear consensus on how to manage antiplatelet therapy during and after carotid interventions. OBJECTIVE: The objective was to undertake a systematic literature review and perform a meta-analysis to assess the effects of dual antiplatelet therapy in carotid endarterectomy (CEA) and stenting (CAS)...
November 26, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27886815/antiplatelet-therapy-for-secondary-prevention-after-acute-myocardial-infarction
#2
REVIEW
Ilaria Cavallari, Marc P Bonaca
Patients with prior myocardial infarction (MI) are at long-term heightened risk for recurrent ischemic events. Several large randomized controlled trials have demonstrated the benefit of more intensive antiplatelet strategies for long-term secondary prevention of cardiovascular death, recurrent MI, and stroke in patients with a history of MI at a cost of increased bleeding. The bleeding risk associated with long-term intensive antiplatelet strategies requires careful patient selection and involvement of patients in shared decision making regarding risks and benefits of therapy...
January 2017: Interventional cardiology clinics
https://www.readbyqxmd.com/read/27863358/temporal-trends-and-long-term-follow-up-of-implantable-cardioverter-defibrillator-therapy-for-secondary-prevention-a-15-year-single-centre-experience
#3
Maria Luce Caputo, François Regoli, Giulio Conte, Boris Adjibodou, Stefano Svab, Alessandro Del Bufalo, Tiziano Moccetti, Moreno Curti, Catherine Klersy, Angelo Auricchio
BACKGROUND: The aim of this study was to determine overall and aetiology-related incidence of secondary prevention ICD implantation over the last 15years in Canton Ticino and to assess clinical outcome according to time period of implantation. METHODS AND RESULTS: Consecutive patients treated by implantation of an ICD for secondary prevention from 2000 to 2015 were included in the current study and compared between 5-year cohorts (2000/2004; 2005/2009; 2010/2015)...
November 10, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27823691/the-prevalence-and-prognostic-importance-of-possible-familial-hypercholesterolemia-in-patients-with-myocardial-infarction
#4
Sofie Aagaard Rerup, Lia E Bang, Ulrik M Mogensen, Thomas Engstrøm, Erik Jørgensen, Frants Pedersen, Christian Torp-Pedersen, Gunnar Gislason, Stefan James, Emil Hagström, Lars Køber, Emil L Fosbøl
AIMS: Familial hypercholesterolemia (FH) is a common genetic disorder causing accelerated atherosclerosis and premature cardiovascular disease. The aim of this study was to examine the prevalence and prognostic significance of possible FH in patients with myocardial infarction (MI). METHODS AND RESULTS: By individual-level linkage of data from the Eastern Danish Heart Registry and national administrative registries, a study population of patients referred for coronary angiography due to MI was selected...
November 2016: American Heart Journal
https://www.readbyqxmd.com/read/27810296/safety-and-efficacy-of-vorapaxar-in-secondary-prevention-of-atherosclerotic-disease-a-meta-analysis-of-randomized-control-trials
#5
Abhishek Sharma, Gérard Helft, Aakash Garg, Sahil Agrawal, Saurav Chatterjee, Carl J Lavie, Sunny Goel, Debabrata Mukherjee, Jonathan D Marmur
OBJECTIVE: To study the cumulative evidence for vorapaxar use in patients with atherosclerotic cardiovascular disease. METHODS: A systematic review of randomized control trials in MEDLINE, EMBASE, EBSCO, CINAHL, Web of Science and Cochrane databases comparing vorapaxar with placebo was performed. Pre-specified efficacy endpoints were all-cause mortality, CV mortality, myocardial infarction (MI), ischemic stroke and repeat revascularization. The pre-specified safety endpoint was intracranial hemorrhage (ICH) and a composite of TIMI major and minor bleeding...
October 29, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27801991/short-to-midterm-effectiveness-of-a-brief-motivational-intervention-to-reduce-alcohol-use-and-related-problems-for-alcohol-intoxicated-children-and-adolescents-in-pediatric-emergency-departments-a-randomized-controlled-trial
#6
Nicolas Arnaud, Silke Diestelkamp, Lutz Wartberg, Peter-Michael Sack, Anne Daubmann, Rainer Thomasius
OBJECTIVES: The proportion of children and adolescents receiving emergency care for acute alcohol intoxication (AAI) in Germany has sharply increased over the past years. Despite this, no randomized controlled trials (RCTs) have studied guideline- and evidence-based interventions to prevent future alcohol misuse within this population. The objective of our investigation was to evaluate the effectiveness of a brief motivational intervention (b-MI) to reduce drinking and associated problems within pediatric emergency departments (PED) in Hamburg, Germany...
November 1, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/27784731/predictors-and-impact-of-in-hospital-recurrent-myocardial-infarction-in-patients-with-acute-coronary-syndrome-findings-from-gulf-race-2
#7
Abdullah S Al Saleh, Khalid F Alhabib, Alawi A Alsheik-Ali, Khadim Sulaiman, Hussam Alfaleh, Shukri Alsaif, Wael Al Mahmeed, Nidal Asaad, Haiham Amin, Ahmed Al-Motarreb, Jassim Al Suwaidi, Ahmad S Hersi
BACKGROUND: Little is known about the predictors and prognostic impact of recurrent in-hospital ischemia and infarction in patients with acute coronary syndrome (ACS). Our objectives were to determine the baseline characteristics, risk factors, and long-term outcomes of patients with recurrent myocardial infarction (Re-MI). METHODS: We evaluated patients with ACS who were enrolled in the second Gulf Registry of Acute Coronary Events from October 2008 to June 2009...
October 26, 2016: Angiology
https://www.readbyqxmd.com/read/27753982/sy-08-2-hypertension-management-for-secondary-prevention-of-stroke
#8
Kazuyuki Shimada
Stroke is known to frequently recur in patients with a history of cerebrovascular disease, and the control of hypertension is extremely important for the treatment of those patients. The robust relationship between the recurrent cerebrovascular disease and blood pressure control has been demonstrated in large-scale clinical studies. The antihypertensive drug therapy significantly reduces the recurrence rate of all types of cerebrovascular disease, incidences of myocardial infarction and all vascular events...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27744207/prevalence-and-incidence-of-q-wave-unrecognized-myocardial-infarction-in-general-population-diagnostic-value-of-the-electrocardiogram-the-regicor-study
#9
Rafel Ramos, Xavier Albert, Joan Sala, Maria Garcia-Gil, Roberto Elosua, Jaume Marrugat, Anna Ponjoan, María Grau, Manel Morales, Antoni Rubió, Pedro Ortuño, Lia Alves-Cabratosa, Ruth Martí-Lluch
BACKGROUND: Diagnosis of unrecognized myocardial infarction (UMI) remains an open question in epidemiological and clinical studies, inhibiting effective secondary prevention of myocardial infarction. We aimed to determine the prevalence and incidence of Q-wave UMI in asymptomatic individuals aged 35 to 74years, and to ascertain the positive predictive value (PPV) of asymptomatic Q-wave to diagnose UMI. METHODS: Two population-based cross-sectional studies were conducted, in 2000 (with 10-year follow-up) and in 2005...
October 5, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27673306/association-between-lowering-ldl-c-and-cardiovascular-risk-reduction-among-different-therapeutic-interventions-a-systematic-review-and-meta-analysis
#10
Michael G Silverman, Brian A Ference, Kyungah Im, Stephen D Wiviott, Robert P Giugliano, Scott M Grundy, Eugene Braunwald, Marc S Sabatine
IMPORTANCE: The comparative clinical benefit of nonstatin therapies that reduce low-density lipoprotein cholesterol (LDL-C) remains uncertain. OBJECTIVE: To evaluate the association between lowering LDL-C and relative cardiovascular risk reduction across different statin and nonstatin therapies. DATA SOURCES AND STUDY SELECTION: The MEDLINE and EMBASE databases were searched (1966-July 2016). The key inclusion criteria were that the study was a randomized clinical trial and the reported clinical outcomes included myocardial infarction (MI)...
September 27, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27662521/patterns-of-antiplatelet-drug-use-after-a-first-myocardial-infarction-during-a-10-year-period
#11
Alfi Yasmina, Anthonius de Boer, Vera H M Deneer, Patrick C Souverein, Olaf H Klungel
AIMS: The aims of the present study were to assess antiplatelet drug use patterns after a first myocardial infarction (MI) and to evaluate the determinants of antiplatelet nonpersistence. METHODS: The present study was conducted in 4690 patients from the Utrecht Cardiovascular Pharmacogenetics cohort with a first MI between 1986 and 2010, who were followed for a maximum of 10 years. Medication use and event diagnosis were obtained from the Dutch PHARMO Record Linkage System...
September 23, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27659349/blood-lead-concentrations-and-attention-deficit-hyperactivity-disorder-in-korean-children-a-hospital-based-case-control-study
#12
Jae Hong Park, Ju-Hee Seo, Young-Seoub Hong, Yu-Mi Kim, Je-Wook Kang, Jae-Ho Yoo, Hee Won Chueh, Jung Hyun Lee, Min Jung Kwak, Jeongseon Kim, Hae Dong Woo, Dong Woo Kim, Young Rong Bang, Byeong Moo Choe
BACKGROUND: Because the developing brain of a child is vulnerable to environmental toxins, even very low concentration of neurotoxin can affect children's neurodevelopment. Lead is a neurotoxic heavy metal which has the harmful effect on the striatal-frontal circuit of brain. This area of the brain is known to be closely related to attention deficit hyperactivity disorder (ADHD) pathophysiology. The primary objective of the present study was to investigate whether elevated blood lead concentration is a risk factor for ADHD...
September 22, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27642893/sy-08-2-hypertension-management-for-secondary-prevention-of-stroke
#13
Kazuyuki Shimada
Stroke is known to frequently recur in patients with a history of cerebrovascular disease, and the control of hypertension is extremely important for the treatment of those patients. The robust relationship between the recurrent cerebrovascular disease and blood pressure control has been demonstrated in large-scale clinical studies. The antihypertensive drug therapy significantly reduces the recurrence rate of all types of cerebrovascular disease, incidences of myocardial infarction and all vascular events...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27588731/residual-ischemic-risk-and-its-determinants-in-patients-with-previous-myocardial-infarction-and-without-prior-stroke-or-tia-insights-from-the-reach-registry
#14
Jérémie Abtan, Deepak L Bhatt, Yedid Elbez, Emmanuel Sorbets, Kim Eagle, Yasuo Ikeda, David Wu, Mary E Hanson, Hakima Hannachi, Puneet K Singhal, Philippe Gabriel Steg, Gregory Ducrocq
BACKGROUND: Although the rate of in-hospital ischemic events after myocardial infarction (MI) has dramatically decreased, long-term residual risk may remain substantial. However, most of the information on current residual risk is derived from highly selected randomized trials. HYPOTHESIS: In patients with previous MI and no prior ischemic stroke/transient ischemic attack (TIA), residual ischemic risk increases over time. METHODS: Using the international Reduction of Atherothrombosis for Continued Health (REACH) registry, we analyzed baseline characteristics and 4-year follow-up of patients with previous MI and no history of stroke/TIA to describe annual rates of recurrent ischemic events globally and by geography...
September 2, 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/27576777/prasugrel-versus-ticagrelor-in-patients-with-acute-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention-multicenter-randomized-prague-18-study
#15
Zuzana Motovska, Ota Hlinomaz, Roman Miklik, Milan Hromadka, Ivo Varvarovsky, Jaroslav Dusek, Jiri Knot, Jiri Jarkovsky, Petr Kala, Richard Rokyta, Frantisek Tousek, Petra Kramarikova, Bohumil Majtan, Stanislav Simek, Marian Branny, Jan Mrozek, Pavel Cervinka, Jiri Ostransky, Petr Widimsky
BACKGROUND: No randomized "head-to-head" comparison of the efficacy and safety of ticagrelor vs. prasugrel has been published in the seven years since the higher efficacy of these newer P2Y12 inhibitors were first demonstrated relative to clopidogrel. METHODS: This academic study was designed to compare the efficacy and safety of prasugrel and ticagrelor in acute myocardial infarction (AMI) treated with primary or immediate percutaneous coronary intervention (PCI)...
August 30, 2016: Circulation
https://www.readbyqxmd.com/read/27567497/does-the-quality-of-safetalk-motivational-interviewing-counseling-predict-sexual-behavior-outcomes-among-people-living-with-hiv
#16
Catherine Grodensky, Carol Golin, Megha A Parikh, Rebecca Ochtera, Carlye Kincaid, Jennifer Groves, Laura Widman, Chirayath Suchindran, Camille McGirt, Kemi Amola, Steven Bradley-Bull
OBJECTIVE: Although past research has demonstrated a link between the quality of motivational interviewing (MI) counseling and client behavior change, this relationship has not been examined in the context of sexual risk behavior among people living with HIV/AIDS. We studied MI quality and unprotected anal/vaginal intercourse (UAVI) in the context of SafeTalk, an evidence-based secondary HIV prevention intervention. METHODS: We used a structured instrument (the MISC 2...
August 13, 2016: Patient Education and Counseling
https://www.readbyqxmd.com/read/27564212/clinical-and-economic-outcomes-among-elderly-myocardial-infarction-survivors-in-the-united-states
#17
Erru Yang, Michael Stokes, Saga Johansson, Carl Mellström, Elizabeth Magnuson, David J Cohen, Phillip Hunt
OBJECTIVES: Longitudinal data are limited regarding outcomes and costs beyond 1 year after acute myocardial infarction (MI) among elderly (≥65 years old) US patients. This study examined long-term outcomes and healthcare costs among elderly MI survivors. METHODS: Retrospective analysis of 2002-2009 Medicare healthcare claims (5% random sample). Patients were ≥65 years old and survived ≥1 year without recurrent MI after MI hospitalization. Mortality, incidence of hospitalizations for stroke, major bleeding, MI, a composite endpoint (death, MI, or stroke), and nonpharmacy healthcare costs were determined...
December 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27558904/is-the-incidence-of-heart-attack-still-decreasing-in-australia-developing-reliable-methods-for-monitoring-trends-in-myocardial-infarction-and-coronary-heart-disease-aus-mocha-a-study-protocol
#18
Lee Nedkoff, Matthew Knuiman, Michael S T Hobbs, Joseph Hung, Sushma Mathur, John Beilby, Anna Reynolds, Tom G Briffa, Derrick Lopez, Frank M Sanfilippo
INTRODUCTION: Accurate monitoring of acute coronary heart disease (CHD) is essential for understanding the effects of primary and secondary prevention and for planning of healthcare services. The ability to reliably monitor acute CHD has been affected by new diagnostic tests for myocardial infarction (MI) and changing clinical classifications and management of CHD. Our study will develop new and reliable methods for monitoring population trends in incidence, outcomes and health service usage for acute CHD and chest pain...
August 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27541822/treatment-outcomes-and-adherence-to-medication-regimens-among-dual-medicare-medicaid-eligible-adults-with-myocardial-infarction
#19
Jacob A Doll, Anne S Hellkamp, Abhinav Goyal, Nadia R Sutton, Eric D Peterson, Tracy Y Wang
Importance: Patients with dual Medicare-Medicaid eligibility have a higher burden of chronic disease conditions and increased health care utilization compared with patients with Medicare coverage alone, but the treatment patterns and outcomes of dual-eligible patients with myocardial infarction (MI) are unknown. Objective: To examine the association of dual-eligible status with clinical outcomes and adherence to medication regimens (hereinafter "medication adherence") among older adults after MI...
August 17, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27539884/haptoglobin-2-2-genotype-and-the-risk-of-coronary-artery-disease-in-the-diabetes-control-and-complications-trial-epidemiology-of-diabetes-interventions-and-complications-study-dcct-edic
#20
Trevor J Orchard, Jye-Yu C Backlund, Tina Costacou, Patricia Cleary, Maria Lopes-Virella, Andrew P Levy, John M Lachin
AIMS/HYPOTHESIS: Haptoglobin(Hp) 2-2 genotype has been shown to increase coronary artery disease (CAD) risk in numerous type 2 diabetes studies but in only one type 1 diabetes cohort. We assessed the association of Hp2-2 with incident CAD over 26years of follow-up in 1303 Caucasian participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. METHODS: DCCT randomized volunteers with type 1 diabetes to intensive versus conventional therapy within two cohorts: 'primary prevention' with 1-5years diabetes duration and 'secondary intervention' with 1-15years diabetes duration and early retinopathy, with or without albuminuria, but no advanced complications...
November 2016: Journal of Diabetes and its Complications
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