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Secondary prevention MI

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https://www.readbyqxmd.com/read/29200861/statin-therapy-for-preventing-cardiovascular-diseases-in-patients-treated-with-tacrolimus-after-kidney-transplantation
#1
Nayoung Han, Seung Hee Han, Yun-Kyoung Song, Myeong Gyu Kim, Yon Su Kim, In-Wha Kim, Jung Mi Oh
Background: Lipid abnormalities are prevalent in tacrolimus-treated patients. The aim of the study was to evaluate the preventive effects of statin therapy on major adverse cardiovascular events (MACE) in patients treated with tacrolimus-based immunosuppression after kidney transplantation (KT), and to identify the risk factors. Methods: This observational cohort study included adult patients who underwent KT and were treated with tacrolimus. Patients who received any lipid-lowering agents except statins, or had a history of immunosuppressant use before transplantation were excluded...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29196298/risk-assessment-in-patients-with-diabetes-with-the-timi-risk-score-for-atherothrombotic-disease
#2
Brian A Bergmark, Deepak L Bhatt, Eugene Braunwald, David A Morrow, Ph Gabriel Steg, Yared Gurmu, Avivit Cahn, Ofri Mosenzon, Itamar Raz, Erin Bohula, Benjamin M Scirica
OBJECTIVE: Improved risk assessment for patients with type 2 diabetes and elevated cardiovascular (CV) risk is needed. The TIMI Risk Score for Secondary Prevention (TRS 2°P) predicts a gradient of risk in patients with prior myocardial infarction (MI) but has not been evaluated in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: CV event rates were compared by baseline TRS 2°P in 16,488 patients enrolled in SAVOR-TIMI 53 with type 2 diabetes and high CV risk or established CV disease...
December 1, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29176897/long-term-prognostic-impact-of-left-ventricular-remodeling-after-a-first-myocardial-infarction-in-modern-clinical-practice
#3
Christophe Bauters, Emilie Dubois, Sina Porouchani, Eric Saloux, Marie Fertin, Pascal de Groote, Nicolas Lamblin, Florence Pinet
BACKGROUND: The association of left ventricular remodeling (LVR) after myocardial infarction (MI) with the subsequent risk of heart failure (HF) and death has not been studied in patients receiving optimal secondary prevention. METHODS AND RESULTS: We performed a long-term clinical follow-up of patients included in 2 prospective multicentric studies on LVR after first anterior MI. At 1-year echocardiography, LVR (≥20% increase in end-diastolic volume from baseline to 1 year) occurred in 67/215 (31%) patients in cohort 1 and in 87/226 (38%) patients in cohort 2...
2017: PloS One
https://www.readbyqxmd.com/read/29150806/ticagrelor-a-review-in-long-term-secondary-prevention-of-cardiovascular-events
#4
Zaina T Al-Salama, Gillian M Keating, Susan J Keam
Ticagrelor (Brilique(®)) is an orally administered P2Y12 inhibitor. A long-term (maintenance) regimen of ticagrelor 60 mg twice daily is indicated in the EU for coadministration with low-dose aspirin 75-150 mg/day for the secondary prevention of atherothrombotic events in high-risk patients with a history of myocardial infarction (MI) of at least 1 year. Approval is based on the results of the PEGASUS-TIMI 54 trial that compared ticagrelor with placebo (in conjunction with low-dose aspirin) in stable patients who had had a spontaneous MI 1-3 years prior to enrolment and were at high risk of atherothrombotic events...
November 18, 2017: Drugs
https://www.readbyqxmd.com/read/29105492/real-world-cardiovascular-disease-burden-in-patients-with-atherosclerotic-cardiovascular-disease-a-comprehensive-systematic-literature-review
#5
Dasha Cherepanov, Tanya Bentley, Wendy Hsiao, Pin Xiang, Frank O'Neill, Yi Qian, Nicole Yurgin, David Beenhouwer
OBJECTIVE: Based on randomized controlled trials (RCT), non-fatal myocardial infarction (MI) rates range between 9-15 events per 1,000 person-year, ischemic stroke between 4-6 per 1,000 person-year, CHD death rates between 5-7 events per 1,000 person-year, any major vascular event between 28-53 per 1,000 person-year in patients with atherosclerotic cardiovascular disease (ASCVD). We reviewed global literature on the topic to determine if the real-world burden of secondary major adverse cardiovascular events (MACEs) is higher among ASCVD patients...
November 5, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29103068/antiplatelet-therapy-for-secondary-prevention-of-vascular-disease-complications
#6
REVIEW
Rahul R Goli, Mayur M Contractor, Ashwin Nathan, Sony Tuteja, Taisei Kobayashi, Jay Giri
PURPOSE OF REVIEW: Platelets are activated upon interaction with injured vascular endothelium to form a primary hemostatic plug. Pathogenic thrombosis driven by platelet aggregation can occur in the setting of vascular disease leading to ischemic events. The use of antiplatelet agents has become a mainstay for prevention of the secondary complications of vascular disease. This review summarizes seminal and recent literature related to this area. RECENT FINDINGS: Aspirin is a cornerstone of antiplatelet therapy for coronary artery disease and cerebrovascular disease for prevention of myocardial infarction, stroke, and vascular death...
November 4, 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29098393/intraoperative-administration-of-dexmedetomidine-reduced-the-postoperative-catheter-related-bladder-discomfort-and-pain-in-patients-undergoing-lumbar-microdiscectomy
#7
Youngsuk Kwon, Ji Su Jang, Sung Mi Hwang, Jae Jun Lee, Hyonjin Tark
PURPOSE: We aimed to evaluate the effect of the intraoperative dexmedetomidine (DEX) on the incidence and severity of catheter-related bladder discomfort (CRBD) after non-urologic surgery. The secondary aim was to find the correlation between the levels of CRBD and postoperative pain sensation. METHODS: Adult male patients undergoing lumbar microdiscectomy were enrolled. Patients were randomized into two groups. After propofol administration, group D (n = 35) received DEX at a loading dose of 1 μg/kg over 10 min, followed by a continuous infusion of 0...
November 2, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/29079906/a-summary-and-evaluation-of-current-evidence-for-myocardial-infarction-with-chinese-medicine
#8
Yue Wang, Lu Xiao, Wei Mu, Hai-Long Yu, Shuo Zhang, Gui-Hua Tian, Hong-Cai Shang
OBJECTIVE: To provide evidence-based recommendations for clinical application and provoke thoughts for future researchers by conducting a comprehensive summary and evaluation of the current evidence profifile for the role of Chinese medicine (CM) in treating myocardial infarction (MI). METHODS: Online databases including PubMed, EMBase, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Chinese Biomedical Medicine (CBM), VIP Journal Integration Platform, and Wanfang database were systematically searched for literatures on CM in treating MI...
October 27, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29046434/aristolochic-acids-and-their-derivatives-are-widely-implicated-in-liver-cancers-in-taiwan-and-throughout-asia
#9
Alvin W T Ng, Song Ling Poon, Mi Ni Huang, Jing Quan Lim, Arnoud Boot, Willie Yu, Yuka Suzuki, Saranya Thangaraju, Cedric C Y Ng, Patrick Tan, See-Tong Pang, Hao-Yi Huang, Ming-Chin Yu, Po-Huang Lee, Sen-Yung Hsieh, Alex Y Chang, Bin T Teh, Steven G Rozen
Many traditional pharmacopeias include Aristolochia and related plants, which contain nephrotoxins and mutagens in the form of aristolochic acids and similar compounds (collectively, AA). AA is implicated in multiple cancer types, sometimes with very high mutational burdens, especially in upper tract urothelial cancers (UTUCs). AA-associated kidney failure and UTUCs are prevalent in Taiwan, but AA's role in hepatocellular carcinomas (HCCs) there remains unexplored. Therefore, we sequenced the whole exomes of 98 HCCs from two hospitals in Taiwan and found that 78% showed the distinctive mutational signature of AA exposure, accounting for most of the nonsilent mutations in known cancer driver genes...
October 18, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29040269/elevated-blood-pressure-and-risk-of-mitral-regurgitation-a-longitudinal-cohort-study-of-5-5-million-united-kingdom-adults
#10
Kazem Rahimi, Hamid Mohseni, Catherine M Otto, Nathalie Conrad, Jenny Tran, Milad Nazarzadeh, Mark Woodward, Terence Dwyer, Stephen MacMahon
BACKGROUND: Mitral regurgitation in people without prior cardiac disease is considered a degenerative disease with no established risk factors for its prevention. We aimed to test the hypothesis that elevated systolic blood pressure (SBP) across its usual spectrum is associated with higher risk of mitral regurgitation. METHODS AND FINDINGS: We used linked electronic health records from the United Kingdom Clinical Practice Research Datalink (CPRD) from 1 January 1990 to 31 December 2015...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29037211/pioglitazone-and-the-secondary-prevention-of-cardiovascular-disease-a-meta-analysis-of-randomized-controlled-trials
#11
REVIEW
Marit de Jong, H Bart van der Worp, Yolanda van der Graaf, Frank L J Visseren, Jan Westerink
BACKGROUND AND AIMS: Pioglitazone targets multiple pathogenic pathways involved in the development of cardiovascular diseases (CVD). The aim of this systematic review and meta-analysis is to assess the effects of pioglitazone treatment on the secondary prevention of CVD. METHODS: Randomized-controlled trials of pioglitazone in patients with CVD were identified through PubMed, Embase, Cochrane and CINAHL, in a search up to May 2016. Studies were included if pioglitazone was compared with any control (usual care, placebo or active comparator) and if patients were previously diagnosed with CVD...
October 16, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28986358/pulmonary-vasodilation-by-phosphodiesterase-5-inhibition-is-enhanced-and-nitric-oxide-independent-in-early-pulmonary-hypertension-after-myocardial-infarction
#12
Richard W B van Duin, Birgit Houweling, Andre Uitterdijk, Dirk J Duncker, Daphne Merkus
Myocardial infarction (MI) may result in pulmonary hypertension (PH). Inhibition of phosphodiesterase 5 (PDE5), the enzyme responsible for the breakdown of cGMP in vascular smooth muscle, has become part of the contemporary therapeutic armamentarium for pulmonary arterial hypertension and may also be of benefit in PH secondary to MI. Nitric oxide (NO) is an important source of cGMP and can be enhanced in early PH and decreased in severe PH. In the present study we investigated if PDE5-inhibition ameliorates pulmonary hemodynamics in swine with PH secondary to MI and whether NO is essential...
October 6, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28975241/targeting-pioglitazone-hydrochloride-therapy-after-stroke-or-transient-ischemic-attack-according-to-pretreatment-risk-for-stroke-or-myocardial-infarction
#13
Walter N Kernan, Catherine M Viscoli, Jennifer L Dearborn, David M Kent, Robin Conwit, Pierre Fayad, Karen L Furie, Mark Gorman, Peter D Guarino, Silvio E Inzucchi, Amber Stuart, Lawrence H Young
Importance: There is growing recognition that patients may respond differently to therapy and that the average treatment effect from a clinical trial may not apply equally to all candidates for a therapy. Objective: To determine whether, among patients with an ischemic stroke or transient ischemic attack and insulin resistance, those at higher risk for future stroke or myocardial infarction (MI) derive more benefit from the insulin-sensitizing drug pioglitazone hydrochloride compared with patients at lower risk...
November 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28974634/one-year-outcomes-after-minor-stroke-or-high-risk-transient-ischemic-attack-korean-multicenter-stroke-registry-analysis
#14
MULTICENTER STUDY
Hong-Kyun Park, Beom Joon Kim, Moon-Ku Han, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Hyun-Wook Nah, Tai Hwan Park, Sang-Soon Park, Kyung Bok Lee, Jun Lee, Keun-Sik Hong, Yong-Jin Cho, Byung-Chul Lee, Kyung-Ho Yu, Mi-Sun Oh, Joon-Tae Kim, Kang-Ho Choi, Dong-Eog Kim, Wi-Sun Ryu, Jay Chol Choi, Saga Johansson, Su Jin Lee, Won Hee Lee, Ji Sung Lee, Juneyoung Lee, Hee-Joon Bae
BACKGROUND AND PURPOSE: Patients with minor ischemic stroke or transient ischemic attack are at high risk of recurrent stroke and vascular events, which are potentially disabling or fatal. This study aimed to evaluate contemporary subsequent vascular event risk after minor ischemic stroke or transient ischemic attack in Korea. METHODS: Patients with minor ischemic stroke or high-risk transient ischemic attack admitted within 7 days of symptom onset were identified from a Korean multicenter stroke registry database...
November 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28960596/psychosocial-stress-and-major-cardiovascular-events-in-patients-with-stable-coronary-heart-disease
#15
E Hagström, F Norlund, A Stebbins, P W Armstrong, K Chiswell, C B Granger, J López-Sendón, D Pella, J Soffer, R Sy, L Wallentin, H D White, R A H Stewart, C Held
OBJECTIVES: Assess the risk of ischaemic events associated with psychosocial stress in patients with stable coronary heart disease (CHD). METHODS: Psychosocial stress was assessed by a questionnaire in 14 577 patients (median age 65.0, IQR 59, 71; 81.6% males) with stable CHD on optimal secondary preventive therapy in the prospective randomized STABILITY clinical trial. Adjusted Cox regression models were used to assess associations between individual stressors, baseline cardiovascular risk factors and outcomes...
September 28, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28914638/long-term-risk-and-predictors-of-cardiovascular-death-in-stable-coronary-artery-disease-the-coronor-study
#16
Christophe Bauters, Olivier Tricot, Thibaud Meurice, Nicolas Lamblin
BACKGROUND: There is limited knowledge on the residual risk of cardiovascular death (CVD) in patients with stable coronary artery disease (CAD) who receive modern secondary prevention. Our aim was to analyze the causes of death and to determine predictors of CVD in the 5-year CORONOR registry. METHODS: We studied 4184 consecutive CAD outpatients who were free from any myocardial infarction (MI) or coronary revascularization for more than 1 year at inclusion. Antithrombotics were prescribed in 99%, statins in 92%, inhibitors of renin-angiotensin system in 82%, and β-blockers in 79%; 86% had prior coronary revascularization...
December 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28879791/incorporation-of-pcsk9-inhibitors-into-prevention-of-atherosclerotic-cardiovascular-disease
#17
Cezary Wójcik
Primary and secondary prevention of atherosclerotic cardiovascular disease (ASCVD) has become recently more complex than ever, leaving the clinicians perplexed with outdated guidelines and emerging evidence about new LDL-C lowering therapies. 2013 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines have focused on high intensity statin therapy for specific groups of patients, while abandoning long established LDL-C goals, a strategy which no longer seems valid. PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors have emerged as the add-on therapy on top of statins and/or ezetimibe for the treatment of hypercholesterolemia and ASCVD prevention...
September 14, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28861285/pattern-analysis-of-patients-with-temporomandibular-disorders-resulting-from-unilateral-mastication-due-to-chronic-periodontitis
#18
Hye-Mi Jeon, Yong-Woo Ahn, Sung-Hee Jeong, Soo-Min Ok, Jeomil Choi, Ju-Youn Lee, Ji-Young Joo, Eun-Young Kwon
PURPOSE: The purpose of the present study was to perform a pattern analysis in patients with temporomandibular disorder (TMD) resulting from unilateral mastication due to chronic periodontitis. METHODS: Thirty participants with signs or symptoms of TMD who engaged in unilateral mastication due to periodontitis-related discomfort (test group) were selected. Another 30 subjects exhibiting signs or symptoms of TMD resulting from unilateral mastication not due to chronic periodontitis (control group) were also recruited...
August 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/28842444/-1-h-mrs-metabolites-and-rate-of-%C3%AE-amyloid-accumulation-on-serial-pet-in-clinically-normal-adults
#19
Zuzana Nedelska, Scott A Przybelski, Timothy G Lesnick, Christopher G Schwarz, Val J Lowe, Mary M Machulda, Walter K Kremers, Michelle M Mielke, Rosebud O Roberts, Bradley F Boeve, David S Knopman, Ronald C Petersen, Clifford R Jack, Kejal Kantarci
OBJECTIVE: To assess whether noninvasive proton magnetic resonance spectroscopy ((1)H-MRS) tissue metabolite measurements at baseline can predict an increase in the rate of β-amyloid (Aβ) accumulation on serial PET in clinically normal (CN) older adults. METHODS: Consecutive participants aged 60 years and older (n = 594) from the Mayo Clinic Study of Aging who were CN at baseline and who underwent (1)H-MRS from the posterior cingulate voxel and longitudinal (11)C-Pittsburgh compound B (PiB)-PET were included...
September 26, 2017: Neurology
https://www.readbyqxmd.com/read/28826823/medication-use-in-long-term-survivors-from-the-monica-kora-myocardial-infarction-registry
#20
Ute Amann, Inge Kirchberger, Margit Heier, Christian Thilo, Bernhard Kuch, Christa Meisinger
BACKGROUND: Prior studies reported high guideline adherence for secondary prevention medications (SPM) at hospital discharge in patients with acute myocardial infarction (AMI). Less is known about medication use in long-term AMI survivors. METHODS: Of the 2077 registered persons with an AMI between 2000 and 2008 who responded to a postal follow-up survey in 2011, 1311 men and 356 women, aged between 34.4 and 84.9years, reported medication intake 7days prior to the survey...
August 18, 2017: European Journal of Internal Medicine
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