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Secondary prevention MI

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https://www.readbyqxmd.com/read/28986358/pulmonary-vasodilation-by-phosphodiesterase-5-inhibition-is-enhanced-and-nitric-oxide-independent-in-early-pulmonary-hypertension-after-myocardial-infarction
#1
Richard W B van Duin, Birgit Houweling, Andre Uitterdijk, Dirk J Duncker, Daphne Merkus
Myocardial infarction (MI) may result in pulmonary hypertension (PH). Inhibition of phosphodiesterase 5 (PDE5), the enzyme responsible for the breakdown of cGMP in vascular smooth muscle, has become part of the contemporary therapeutic armamentarium for pulmonary arterial hypertension and may also be of benefit in PH secondary to MI. Nitric oxide (NO) is an important source of cGMP and can be enhanced in early PH and decreased in severe PH. In the present study we investigated if PDE5-inhibition ameliorates pulmonary hemodynamics in swine with PH secondary to MI and whether NO is essential...
October 6, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28975241/targeting-pioglitazone-hydrochloride-therapy-after-stroke-or-transient-ischemic-attack-according-to-pretreatment-risk-for-stroke-or-myocardial-infarction
#2
Walter N Kernan, Catherine M Viscoli, Jennifer L Dearborn, David M Kent, Robin Conwit, Pierre Fayad, Karen L Furie, Mark Gorman, Peter D Guarino, Silvio E Inzucchi, Amber Stuart, Lawrence H Young
Importance: There is growing recognition that patients may respond differently to therapy and that the average treatment effect from a clinical trial may not apply equally to all candidates for a therapy. Objective: To determine whether, among patients with an ischemic stroke or transient ischemic attack and insulin resistance, those at higher risk for future stroke or myocardial infarction (MI) derive more benefit from the insulin-sensitizing drug pioglitazone hydrochloride compared with patients at lower risk...
September 18, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28974634/one-year-outcomes-after-minor-stroke-or-high-risk-transient-ischemic-attack-korean-multicenter-stroke-registry-analysis
#3
Hong-Kyun Park, Beom Joon Kim, Moon-Ku Han, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Hyun-Wook Nah, Tai Hwan Park, Sang-Soon Park, Kyung Bok Lee, Jun Lee, Keun-Sik Hong, Yong-Jin Cho, Byung-Chul Lee, Kyung-Ho Yu, Mi-Sun Oh, Joon-Tae Kim, Kang-Ho Choi, Dong-Eog Kim, Wi-Sun Ryu, Jay Chol Choi, Saga Johansson, Su Jin Lee, Won Hee Lee, Ji Sung Lee, Juneyoung Lee, Hee-Joon Bae
BACKGROUND AND PURPOSE: Patients with minor ischemic stroke or transient ischemic attack are at high risk of recurrent stroke and vascular events, which are potentially disabling or fatal. This study aimed to evaluate contemporary subsequent vascular event risk after minor ischemic stroke or transient ischemic attack in Korea. METHODS: Patients with minor ischemic stroke or high-risk transient ischemic attack admitted within 7 days of symptom onset were identified from a Korean multicenter stroke registry database...
October 3, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28960596/psychosocial-stress-and-major-cardiovascular-events-in-patients-with-stable-coronary-heart-disease
#4
Emil Hagström, Fredrika Norlund, Amanda Stebbins, Paul W Armstrong, Karen Chiswell, Christopher B Granger, José López-Sendón, Daniel Pella, Joseph Soffer, Rody Sy, Lars Wallentin, Harvey D White, Ralph A H Stewart, Claes Held
OBJECTIVES: Assess the risk of ischemic events associated with psychosocial stress in patients with stable coronary heart disease (CHD). METHODS: Psychosocial stress was assessed by a questionnaire in 14,577 patients (median age 65.0, IQR 59, 71; 81.6% males) with stable CHD on optimal secondary preventive therapy in the prospective randomised STABILITY clinical trial. Adjusted Cox regression models were used to assess associations between individual stressors, baseline cardiovascular risk factors, and outcomes...
September 28, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28914638/long-term-risk-and-predictors-of-cardiovascular-death-in-stable-coronary-artery-disease-the-coronor-study
#5
Christophe Bauters, Olivier Tricot, Thibaud Meurice, Nicolas Lamblin
BACKGROUND: There is limited knowledge on the residual risk of cardiovascular death (CVD) in patients with stable coronary artery disease (CAD) who receive modern secondary prevention. Our aim was to analyze the causes of death and to determine predictors of CVD in the 5-year CORONOR registry. METHODS: We studied 4184 consecutive CAD outpatients who were free from any myocardial infarction (MI) or coronary revascularization for more than 1 year at inclusion. Antithrombotics were prescribed in 99%, statins in 92%, inhibitors of renin-angiotensin system in 82%, and β-blockers in 79%; 86% had prior coronary revascularization...
September 13, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28879791/incorporation-of-pcsk9-inhibitors-into-prevention-of-atherosclerotic-cardiovascular-disease
#6
Cezary Wójcik
Primary and secondary prevention of atherosclerotic cardiovascular disease (ASCVD) has become recently more complex than ever, leaving the clinicians perplexed with outdated guidelines and emerging evidence about new LDL-C lowering therapies. 2013 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines have focused on high intensity statin therapy for specific groups of patients, while abandoning long established LDL-C goals, a strategy which no longer seems valid. PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors have emerged as the add-on therapy on top of statins and/or ezetimibe for the treatment of hypercholesterolemia and ASCVD prevention...
September 7, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28861285/pattern-analysis-of-patients-with-temporomandibular-disorders-resulting-from-unilateral-mastication-due-to-chronic-periodontitis
#7
Hye-Mi Jeon, Yong-Woo Ahn, Sung-Hee Jeong, Soo-Min Ok, Jeomil Choi, Ju-Youn Lee, Ji-Young Joo, Eun-Young Kwon
PURPOSE: The purpose of the present study was to perform a pattern analysis in patients with temporomandibular disorder (TMD) resulting from unilateral mastication due to chronic periodontitis. METHODS: Thirty participants with signs or symptoms of TMD who engaged in unilateral mastication due to periodontitis-related discomfort (test group) were selected. Another 30 subjects exhibiting signs or symptoms of TMD resulting from unilateral mastication not due to chronic periodontitis (control group) were also recruited...
August 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/28842444/-1-h-mrs-metabolites-and-rate-of-%C3%AE-amyloid-accumulation-on-serial-pet-in-clinically-normal-adults
#8
Zuzana Nedelska, Scott A Przybelski, Timothy G Lesnick, Christopher G Schwarz, Val J Lowe, Mary M Machulda, Walter K Kremers, Michelle M Mielke, Rosebud O Roberts, Bradley F Boeve, David S Knopman, Ronald C Petersen, Clifford R Jack, Kejal Kantarci
OBJECTIVE: To assess whether noninvasive proton magnetic resonance spectroscopy ((1)H-MRS) tissue metabolite measurements at baseline can predict an increase in the rate of β-amyloid (Aβ) accumulation on serial PET in clinically normal (CN) older adults. METHODS: Consecutive participants aged 60 years and older (n = 594) from the Mayo Clinic Study of Aging who were CN at baseline and who underwent (1)H-MRS from the posterior cingulate voxel and longitudinal (11)C-Pittsburgh compound B (PiB)-PET were included...
September 26, 2017: Neurology
https://www.readbyqxmd.com/read/28826823/medication-use-in-long-term-survivors-from-the-monica-kora-myocardial-infarction-registry
#9
Ute Amann, Inge Kirchberger, Margit Heier, Christian Thilo, Bernhard Kuch, Christa Meisinger
BACKGROUND: Prior studies reported high guideline adherence for secondary prevention medications (SPM) at hospital discharge in patients with acute myocardial infarction (AMI). Less is known about medication use in long-term AMI survivors. METHODS: Of the 2077 registered persons with an AMI between 2000 and 2008 who responded to a postal follow-up survey in 2011, 1311 men and 356 women, aged between 34.4 and 84.9years, reported medication intake 7days prior to the survey...
August 18, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28814290/predicted-impact-of-lipid-lowering-therapy-on-cardiovascular-and-economic-outcomes-of-swedish-atherosclerotic-cardiovascular-disease-guideline
#10
Gunilla Journath, Kristina Hambraeus, Emil Hagström, Billie Pettersson, Mickael Löthgren
BACKGROUND: The effects on cardiovascular disease (CVD) by treatment recommendations on prevention of atherosclerotic CVD remain to be evaluated. The objectives were to assess treatment gap for low density lipoprotein cholesterol (LDL-C) according to guidelines, potential impact on CVD outcomes, and possible avoided economic costs, in post myocardial infarction (MI) patients, if target LDL-C levels of ≤1.8 mmol/L would be achieved. METHODS: All patients registered in the Swedish Secondary Prevention after Heart Intensive care Admission register, with one-year post-MI follow-up during 2013 were selected...
August 16, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28801383/long-term-outcomes-after-acute-myocardial-infarction-in-countries-with-different-socioeconomic-environments-an-international-prospective-cohort-study
#11
Judith Kämpfer, Andriy Yagensky, Tomasz Zdrojewski, Stephan Windecker, Bernhard Meier, Mykhailo Pavelko, Iryna Sichkaruk, Piotr Kasprzyk, Marzin Gruchala, Mikael Giacomini, Lukas Räber, Hugo Saner
BACKGROUND: Hospital-based data on the impact of socioeconomic environment on long-term survival after myocardial infarction (MI) are lacking. We compared outcome and quality of secondary prevention in patients after MI living in three different socioeconomic environments including patients from three tertiary-care teaching hospitals with similar service population size in Switzerland, Poland and Ukraine. METHODS: This is a prospective cohort study of patients with a first MI in three different tertiary-care teaching hospitals in Bern (Switzerland), Gdansk (Poland) and Lutsk (Ukraine) during the acute phase in the year 2010 and follow-up of these patients with a questionnaire and, if necessary, telephone interviews 3...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28760215/interventions-supporting-long-term-adherence-and-decreasing-cardiovascular-events-island-pragmatic-randomized-trial-protocol
#12
RANDOMIZED CONTROLLED TRIAL
Noah Ivers, J-D Schwalm, Holly O Witteman, Justin Presseau, Monica Taljaard, Tara McCready, Beth Bosiak, Jennifer Cunningham, Shelley Smarz, Laura Desveaux, Jack V Tu, Clare Atzema, Garth Oakes, Wanrudee Isaranuwatchai, Sherry L Grace, R Sacha Bhatia, Madhu Natarajan, Jeremy M Grimshaw
BACKGROUND: Guidelines recommend cardiac rehabilitation and long-term use of cardiac medications for most patients who have had a myocardial infarction (MI), but adherence to these secondary prevention treatments is suboptimal. METHODS: This is a multicenter, pragmatic, 3-arm randomized trial. Eligible patients (n = 2,742) with obstructive coronary artery disease are randomized post-MI to usual care or 1 of 2 intervention arms. Patients in the first intervention arm receive mail-outs sent on behalf of their cardiologist at 4, 8, 20, 32, and 44 weeks post-MI; content is designed to address determinants of adherence and facilitate discussion between the patient and their health care team...
August 2017: American Heart Journal
https://www.readbyqxmd.com/read/28735954/endarterectomy-achieves-lower-stroke-and-death-rates-compared-with-stenting-in-patients-with-asymptomatic-carotid-stenosis
#13
REVIEW
Stavros K Kakkos, Ioannis Kakisis, Ioannis A Tsolakis, George Geroulakos
BACKGROUND: It is currently unclear if carotid artery stenting (CAS) is as safe as carotid endarterectomy (CEA) for patients with significant asymptomatic stenosis. The aim of our study was to perform a systematic review and meta-analysis of trials comparing CAS with CEA. METHODS: On March 17, 2017, a search for randomized controlled trials was performed in MEDLINE and Scopus databases with no time limits. We performed meta-analyses with Peto odds ratios (ORs) and 95% confidence intervals (CIs)...
August 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28712194/blocked-coronary-artery-due-to-coronary-spasm-treated-with-stent-insertion-a-sub-optimal-result
#14
Habib Rehman Khan, Sajid Aslam
Myocardial infarction (MI) is an extremely common cause of chest pain. MI can be acute with ST elevation (STEMI) or non-STEMI (NSTEMI). Coronary artery spasm can be severe enough to cause occlusion of the coronary arteries particularly with an exaggerated response in regions of coronary atheroma and plaque ulceration. It is not uncommon for coronary spasm to be mistaken with acute thrombotic occlusion of the coronary artery. We describe a case of a 42-year old man with known cardiac risk factors presents with chest pain for few hours to a tertiary centre hospital...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28682918/a-randomized-controlled-trial-of-acupressure-as-an-adjunctive-therapy-to-sodium-valproate-on-the-prevention-of-chronic-migraine-with-aura
#15
RANDOMIZED CONTROLLED TRIAL
Ji-Hua Xu, He-Yin Mi
BACKGROUND: The primary objective of the present study was to evaluate the efficacy and safety of using acupressure as an adjunctive therapy to sodium valproate (SV) combined with acupressure (ASV) on the prevention of chronic migraine with aura (CMA). METHODS: A total of 98 patients with CMA were randomly divided into an intervention group and a control group, with 49 patients in each group. The patients in the intervention group received ASV, while the participants in the control group received SV alone...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28680717/effect-of-a-proton-pump-inhibitor-on-tumor-bleeding-prevention-in-unresectable-gastric-cancer-patients-a-double-blind-randomized-placebo-controlled-trial
#16
Young-Il Kim, Mi-Jung Kim, Sook Ryun Park, Hark Kyun Kim, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Gwang Ha Kim, Moo In Park, Byung-Ho Nam, Young Iee Park, Il Ju Choi
PURPOSE: Tumor bleeding is a major complication in inoperable gastric cancer. The study aim was to investigate the effects of proton pump inhibitor (PPI) treatment for the prevention of gastric tumor bleeding. MATERIALS AND METHODS: This study was a prospective double-blind, randomized, placebo-controlled trial. Patients with inoperable gastric cancer were randomly assigned to receive oral lansoprazole (30 mg) or placebo daily. The primary endpoint was the occurrence of tumor bleeding, and the secondary endpoints were transfusion requirement and overall survival (OS)...
June 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28625438/efficacy-of-prophylactic-doses-of-intravenous-nitroglycerin-in-preventing-myocardial-ischemia-under-general-anesthesia-a-systematic-review-and-meta-analysis-with-trial-sequential-analysis
#17
REVIEW
Hiroshi Hoshijima, Yohei Denawa, Takahiro Mihara, Risa Takeuchi, Norifumi Kuratani, Tsutomu Mieda, Yoshinori Iwase, Toshiya Shiga, Zen'ichiro Wajima, Hiroshi Nagasaka
STUDY OBJECTIVE: To evaluate the efficacy of intravenous nitroglycerin (TNG) in preventing intraoperative myocardial ischemia (MI) under general anesthesia. Moreover, we analyzed the hemodynamic changes in heart rate (HR), mean blood pressure (MBP), and pulmonary capillary wedge pressure (PCWP) associated with TNG administration both before and after the induction of anesthesia. DESIGN: Meta-analysis. SETTING: Operating room, cardiac surgery or non-cardiac surgery, all surgeries were elective measurements...
August 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28604119/vorapaxar-in-secondary-prevention-where-we-stand
#18
Anastazia Kei, Moses Elisaf
No abstract text is available yet for this article.
July 6, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28581997/optimal-antiplatelet-therapy-in-st-segment-elevation-myocardial-infarction
#19
REVIEW
Rafael Harari, Usman Baber
Cardiovascular disease is the leading cause of death worldwide. Case-fatality rates for myocardial infarction (MI) in the United States have decreased over the past decades, in large part due to advances in the treatment of acute MI and secondary preventive therapy after MI. Antiplatelet therapy remains the cornerstone of treatment of MI. This article reviews the current state of antiplatelet therapy in ST-segment elevation MI.
October 2016: Interventional cardiology clinics
https://www.readbyqxmd.com/read/28549748/prevalence-of-electrocardiographic-unrecognized-myocardial-infarction-and-its-association-with-mortality
#20
M Yldau van der Ende, Minke H T Hartman, Remco A J Schurer, Hindrik W van der Werf, Erik Lipsic, Harold Snieder, Pim van der Harst
BACKGROUND: Identifying unrecognized myocardial infarction (MI) is important for secondary prevention. The aim of this study is to determine the prevalence and correlates of unrecognized MI and the association with mortality in the general population. METHODS: All participants ≥18years participating in the Lifelines population, a three-generation Cohort Study and Biobank, were included (n=152,180). Participants with unrecognized MI were matched with controls without MI (1:2) based on age and gender...
September 15, 2017: International Journal of Cardiology
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