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Perianal disease

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https://www.readbyqxmd.com/read/28223835/perianal-crohn-s-disease-challenges-and-solutions
#1
REVIEW
Katherine A Kelley, Taranjeet Kaur, Vassiliki L Tsikitis
Perianal Crohn's disease affects a significant number of patients with Crohn's disease and is associated with poor quality of life. The nature of the disease, compounded by presentation of various disease severities, has made the treatment of perianal Crohn's disease difficult. The field continues to evolve with the use of both historical and contemporary solutions to address the challenges associated with it. The goal of this article is to review current literature regarding medical and surgical treatment, as well as the future directions of therapy...
2017: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/28218881/mr-imaging-of-perianal-crohn-disease
#2
Shannon P Sheedy, David H Bruining, Eric J Dozois, William A Faubion, Joel G Fletcher
Pelvic magnetic resonance (MR) imaging is currently the standard for imaging perianal Crohn disease. Perianal fistulas are a leading cause of patient morbidity because closure often requires multimodality treatments over a prolonged period of time. This review summarizes clinically relevant anal sphincter anatomy, imaging methods, classification systems, and treatment objectives. In addition, the MR appearance of healing perianal fistulas and fistula complications is described. Difficult imaging tasks including the assessment of rectovaginal fistulas and ileoanal anastomoses are highlighted, along with illustrative cases...
March 2017: Radiology
https://www.readbyqxmd.com/read/28216137/low-predictive-value-of-histopathological-scoring-system-for-complications-development-in-children-with-crohn-s-disease
#3
Ondrej Fabian, Ondrej Hradsky, Kristyna Potuznikova, Alena Kalfusova, Lenka Krskova, Ludmila Hornofova, Josef Zamecnik, Jiri Bronsky
OBJECTIVES: In pediatric Crohn's disease (PCD), the benefit of microscopy in disease activity assessment and prediction of clinical outcome is, due to the focality and transmurality of the inflammation, disputable. We investigated whether histopathological scoring system predicts complications in pediatric CD and correlates with endoscopical and clinical scores. METHODS: We performed a retrospective study on 63 patients. Endoscopy in the time of diagnosis was evaluated using the Simple Endoscopic Score (SES) and histopathology with the Global Histology Activity Score, both in its original version (GHAS) and its modification (modGHAS)...
January 15, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28214210/pathologic-features-of-colorectal-carcinomas-associated-with-crohn-s-disease-in-korean-population
#4
Jiyoon Kim, Ho-Su Lee, Sang Hyoung Park, Suk-Kyun Yang, Byong Duk Ye, Dong-Hoon Yang, Kyung-Jo Kim, Jeong-Sik Byeon, Yong Sik Yoon, Chang Sik Yu, Jihun Kim
BACKGROUND: Colorectal cancer (CRC) has been known to complicate Crohn's disease (CD). Several reports in Western population revealed that CRC in CD were characterized by much younger onset and equal distribution of tumors along the entire colon. However, clinicopathologic features of CD-associated CRC in Korean population have not been well documented yet. METHODS: Among 2968 Korean CD patients, 16 patients (0.54%) were found to develop CRC during follow up. We reviewed clinicopathologic features of the 16 CRC patients...
December 21, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28211593/higher-infliximab-trough-levels-are-associated-with-perianal-fistula-healing-in-patients-with-crohn-s-disease
#5
A J Yarur, V Kanagala, D J Stein, F Czul, M A Quintero, D Agrawal, A Patel, K Best, C Fox, K Idstein, M T Abreu
BACKGROUND: Infliximab has been found to be efficacious in the treatment of fistulas in the setting of Crohn's disease, even though some patients do not benefit from therapy. AIM: To assess the correlation between perianal fistula healing and trough levels of infliximab. METHODS: In this cross-sectional study, we identified patients with Crohn's disease who had perianal fistulas and were treated with infliximab for at least 24 weeks. We excluded patients who underwent a faecal diversion procedure or proctectomy...
February 17, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28198748/time-trends-in-the-epidemiology-and-outcome-of-perianal-fistulizing-crohn-s-disease-in-a-population-based-cohort
#6
Kevin W A Göttgens, Steven F G Jeuring, Rosel Sturkenboom, Mariëlle J L Romberg-Camps, Liekele E Oostenbrug, Daisy M A E Jonkers, Laurents P S Stassen, Ad A M Masclee, Marieke J Pierik, Stéphanie O Breukink
OBJECTIVE: Perianal disease is a debilitating condition that frequently occurs in Crohn's disease (CD) patients. It is currently unknown whether its incidence has changed in the era of frequent immunomodulator use and biological availability. We studied the incidence and outcome of perianal and rectovaginal fistulas over the past two decades in our population-based Inflammatory Bowel Disease South-Limburg cohort. PATIENTS AND METHODS: All 1162 CD patients registered in the Inflammatory Bowel Disease South-Limburg registry were included...
February 14, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28194515/genital-and-reproductive-organ-complications-of-crohn-disease-technical-considerations-as-it-relates-to-perianal-disease-imaging-features-and-implications-on-management
#7
REVIEW
Steven Kammann, Christine Menias, Amy Hara, Mariam Moshiri, Cary Siegel, Bashar Safar, Steven Brandes, Akram Shaaban, Kumar Sandrasegaran
OBJECTIVE: A relatively large proportion of patients with Crohn disease (CD) develop complications including abscess formation, stricture, and penetrating disease. A subset of patients will have genital and reproductive organ involvement of CD, resulting in significant morbidity. These special circumstances create unique management challenges that must be tailored to the activity, location, and extent of disease. Familiarity with the epidemiology, pathogenesis, imaging features, and treatment strategies for patients with genital CD can aid imaging diagnoses and guide appropriate patient management...
February 13, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28185631/single-stage-transanal-endorectal-pull-through-procedure-for-correction-of-hirschsprung-disease-in-neonates-and-nonneonates-a-multicenter-study
#8
Changgui Lu, Guangjun Hou, Chunyi Liu, Qiming Geng, Xiaoqun Xu, Jie Zhang, Huan Chen, Weibing Tang
PURPOSE: The outcomes of single-stage transanal endorectal pull-through (SSTEPT) for Hirschsprung disease (HSCR) in young patients are favorable; however, reports have shown that diagnosis and surgery at young ages increase the risk for postoperative enterocolitis and slows postoperative recovery. The present study was primarily designed to evaluate the outcomes of SSTEPT in a multi-institutional cohort of neonates and nonneonates with HSCR. METHODS: Between August 2005 and May 2012, a total of 650 children with HSCR were divided into the following two groups: group A (neonatal group, operative age<28days [n=186]); and group B (nonneonatal group, operative age>28days [n=464])...
February 2, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28175223/n802-improving-care-for-patients-with-perianal-crohn-s-disease-review-of-a-perianal-virtual-clinic
#9
H Yarrow, P Irving, A Williams, F Hibberts, I Koumoutsos, A Darakhshan, E Westcott, J Duncan
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175162/p553-long-term-outcomes-of-seton-drainage-for-perianal-fistulizing-crohn-s-disease
#10
E Banayan, K Zagihyan, P Fleshner
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175158/p626-ustekinumab-for-the-treatment-of-perianal-fistulas-in-patients-with-crohn-s-disease
#11
R Battat, T Bessissow, M Strohl, U Kopylov, A Bitton, A Cohen, E Seidman, W Afif
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175104/p494-multicentre-cohort-study-to-evaluate-the-need-for-re-intervention-following-multimodal-treatment-in-crohn-s-disease-with-perianal-fistula
#12
S Sebastian, C Black, D Pugliese, A Armuzzi, K Sahnan, S M Elkady, K H Katsanos, D K Christodoulou, C Selinger, G Maconi, G Fiorino, U Kopylov, Y Davidov, M M Bosca-Watts, P Ellul, M Muscat, K Karmiris, N S Fearnhead, V Allgar, A L Hart, S Ben-Horin, S Danese
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175031/p221-natural-history-of-perianal-crohn-s-disease-in-patients-with-elderly-onset-disease-a%C3%A2-population-based-study
#13
M Danielou, C Mamona, M Barthoulot, B Pariente, M Fumery, H Sarter, C Charpentier, J-L Dupas, G Savoye, C Gower-Rousseau
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175027/p211-differences-in-therapeutic-approaches-and-outcomes-in-paediatric-and-adult-onset-crohn-s-disease-with-perianal-fistula-comparison-of-2-multicentre-fistula-cohorts
#14
S Sebastian, C Black, M V Nair, T Drskova, O Hradsky, C Tzivinikos, K Sahnan, R Muhammed, D Devadason, R S Parmar, K Crook, A Akbar, M Thomson, D Pugliese, A Armuzzi, K H Katsanos, D K Christodoulou, C Selinger, G Maconi, G Fiorino, U Kopylov, M M Bosca-Watts, K Karmiris, P Ellul, S Ben-Horin, S Danese, A L Hart
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175006/dop057-perianal-pediatric-crohn-s-disease-is-associated-with-a-distinct-phenotype-and-greater-inflammatory-burden
#15
A Assa, M Amitai, M-L Greer, D Castro, R Cytter Kuint, M Martínez-Leόn, I Herman-Sucharska, E Coppenrath, S Anupindi, A Towbin, D Moote, O Konen, L-T Pratt, A Grifitths, D Turner
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175004/p153-role-of-3d-endoanal-ultrasound-in-perianal-fistulising-crohns-s-disease-preliminary-results
#16
G Luglio, M C Giglio, A Rispo, N Imperatore, V Sollazzo, R Peltrini, M Sacco, F Castiglione, G D De Palma, L Bucci
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175000/p245-a-systematic-review-of-outcomes-reported-in-studies-on-fistulising-perianal-crohn-s-disease
#17
K Sahnan, S O Adegbola, P J Tozer, B S R Allin, M J Lee, N Heywood, A G K McNair, A J Lobo, S R Brown, S Sebastian, R K Phillips, P F Lung, O D Faiz, S Blackwell, A Verjee, N S Fearnhead, A L Hart
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174984/p126-experience-of-3d-modelling-in-perianal-fistula-disease-and-survey-of-international-surgical-interest
#18
K Sahnan, S O Adegbola, P J Tozer, D Burling, J Warusavitarne, O D Faiz, R K Phillips, A L Hart, P F Lung
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174981/op008-an-innovative-treatment-for-refractory-perianal-fistulas-in-crohn-s-disease-local-micro-reinjection-of-autologous-fat-and-adipose-derived-stromal-vascular-fraction
#19
M Serrero, C Philandrianos, C Visee, J Veran, P Orsoni, F Sabatier, J-C Grimaud
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174947/dop056-pathophysiology-of-perianal-fistulising-disease
#20
B Siegmund, R M Feakins, G Barmias, J Coelho Ludvig, F Vieira Teixeira, G Rogler, M Scharl
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
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