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Perianal disease

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https://www.readbyqxmd.com/read/28614205/spectrum-of-changes-in-anogenital-mammary-like-glands-in-primary-extramammary-anogenital-paget-disease-and-their-possible-role-in-the-pathogenesis-of-the-disease
#1
Anastasia M Konstantinova, Dominic V Spagnolo, Colin J R Stewart, Denisa Kacerovska, Ksenya V Shelekhova, Jose A Plaza, Saul Suster, Jiri Bouda, Liubov Kyrpychova, Michal Michal, Irena E Belousova, Katrin Kerl, Dmitry V Kazakov
To determine whether a subset of primary extramammary Paget disease (EMPD) may originate in anogenital mammary-like glands (AGMLG), the authors studied 181 specimens of EMPD, detailing alterations in AGMLG. The latter were identified in 33 specimens from 31 patients. All patients were women, ranging in age from 38 to 93 years (median, 65 y). In all cases, lesions involved the vulva and in 1 patient the perianal skin was affected. Histopathologically, AGMLG manifested changes identical to columnar cell change (CCC) (87...
June 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28611562/perianal-pagetoid-intraepithelial-carcinoma
#2
Suanga Sisodia, Robin Boushey, Goo Lee, Celia Marginean, Marcio M Gomes, Gaurav Bhattacharya, Kristopher Dennis
Extramammary Paget disease (EMPD) involving the perianal region is rare and challenging to manage. Primary EMPD involves stand-alone noninvasive lesions within the epidermis, while secondary EMPD involves phenotypically similar lesions derived from separate underlying malignancies. Differentiating between primary and secondary EMPD is challenging when no underlying malignancies are detected during workup. Continued reporting of perianal EMPD cases is encouraged so that risk stratification can be improved and patients can be managed with an appropriate level of aggressiveness...
January 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28609809/intestinal-tuberculosis-a-diagnostic-challenge
#3
J Kentley, J L Ooi, J Potter, S Tiberi, T O'Shaughnessy, L Langmead, J Chin Aleong, M A Thaha, H Kunst
OBJECTIVE: To describe characteristics, presentation, time to diagnosis and diagnostic findings of patients with intestinal tuberculosis (ITB) in a low-burden country. METHOD: Retrospective study of 61 consecutive ITB patients diagnosed between 2008-2014 at a large East London hospital. RESULTS: 40 of 61 patients were male. Mean age was 34.6 years. 93% of patients were born abroad, mostly from TB-endemic areas (Indian subcontinent: 88%, Africa: 9%)...
June 13, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28604511/incidence-and-risk-factors-for-perianal-disease-in-pediatric-crohn-s-disease-patients-followed-in-cedata-gpge-registry
#4
Annecarin Brückner, Katharina J Werkstetter, Jan de Laffolie, Claudia Wendt, Christine Prell, Tanja Weidenhausen, Klaus P Zimmer, Sibylle Koletzko
BACKGROUND AND AIMS: Perianal disease (PD) with fistula and/or abscess formation is a severe complication in Crohn's disease (CD). We examined prevalence, incidence and risk factors for PD development in a pediatric CD cohort. METHODS: CD patients from the prospective, multi-center registry for inflammatory bowel disease from Germany and Austria (CEDATA-GPGE) were included if diagnosed ≤18 years of age, registered within three months after diagnosis, and having at least two follow-up visits within the first year of registration...
June 9, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28603049/ethnicity-influences-phenotype-and-outcomes-in-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis-of-population-based-studies
#5
Haiyun Shi, Alexander N Levy, Hirsh D Trivedi, Francis Kl Chan, Siew C Ng, Ashwin N Ananthakrishnan
INTRODUCTION: Inflammatory bowel diseases (IBD; Crohn's disease (CD), ulcerative colitis (UC)) are global diseases. Similarities and differences in disease presentation and outcomes across different geographic regions and ethnic groups have not been compared previously. METHODS: We performed a systematic review and meta-analysis of population based cohort studies examining the phenotype and outcome of IBD across ethnic groups, categorized as Whites, Blacks, Hispanics and Asians...
June 8, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28601423/crohn-disease-epidemiology-diagnosis-and-management
#6
REVIEW
Joseph D Feuerstein, Adam S Cheifetz
Crohn disease is a chronic idiopathic inflammatory bowel disease condition characterized by skip lesions and transmural inflammation that can affect the entire gastrointestinal tract from the mouth to the anus. For this review article, we performed a review of articles in PubMed through February 1, 2017, by using the following Medical Subject Heading terms: crohns disease, crohn's disease, crohn disease, inflammatory bowel disease, and inflammatory bowel diseases. Presenting symptoms are often variable and may include diarrhea, abdominal pain, weight loss, nausea, vomiting, and in certain cases fevers or chills...
June 7, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28597964/interleukin-10-receptor-mutation-presenting-with-severe-nappy-ulceration-and-infantile-inflammatory-bowel-disease
#7
B S McDonald, S Narayanan, M Elawad, F Kiparissi, T Cullup, K Batta
Inflammatory bowel disease (IBD) can be divided into Crohn disease, ulcerative colitis and inflammatory bowel disease unclassified (IBDU). In most patients, these disorders present in adolescence or early adulthood. Patients with infantile IBD can have an associated underlying immunodeficiency disorder caused by a mutation in interleukin (IL)-10 or its receptor. We describe a child presenting with intractable bloody diarrhoea since 2 weeks of age and with severe nappy ulceration, who was ultimately diagnosed as having inflammatory bowel disease (IBD) due to an immunodeficiency in the IL-10 receptor...
June 9, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28594329/updating-predictors-of-endoscopic-recurrence-after-ileocolic-resection-for-crohn-disease
#8
Sara Monteiro, Tiago Cúrdia Gonçalves, Pedro Boal Carvalho, Maria João Moreira, José Cotter
BACKGROUND/AIMS: Identifying predictors of endoscopic recurrence (ER) has become very important to guide the decision of postoperative strategy. This study aimed to determine the rate of endoscopic recurrence until 12 months after ileocolic resection for Crohn disease (CD) in a cohort and identify its possible predictors. MATERIALS AND METHODS: We conducted a retrospective single-center study that included patients with CD who underwent ileocolic resection between 2003 and 2014...
June 7, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28591708/methylation-of-hpv-and-a-tumor-suppressor-gene-reveals-anal-cancer-and-precursor-lesions
#9
Attila T Lorincz, Mayura Nathan, Caroline Reuter, Rhian Warman, Mohamed A Thaha, Michael Sheaff, Natasa Vasiljevic, Amar Ahmad, Jack Cuzick, Peter Sasieni
We studied DNA methylation patterns of human papillomavirus (HPV) and tumor suppressor gene EPB41L3 in 148 anal and perianal biopsies to determine whether high levels of methylation would be associated with anal intraepithelial neoplasia (AIN). The most prevalent HPV type was HPV16, detected in 54% of the 30 benign biopsies, 33% of the 43 low-grade AIN (lgAIN), 82% of the 59 high grade AIN (hgAIN) and 4 of the 5 anal cancers. A methylation score was developed (0.561*HPV16me+0.439*EPB41L3) which had increasing values with severity of disease: the mean was 8...
May 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28590344/the-characteristics-and-long-term-outcomes-of-pediatric-crohn-s-disease-patients-with-perianal-disease
#10
Yonatan Herman, Firas Rinawi, Benjamin Rothschild, Osnat Nir, Raanan Shamir, Amit Assa
BACKGROUND: Data on the outcomes of children with perianal Crohn's disease are limited. We aimed to assess phenotypic features at diagnosis and long-term disease-specific outcomes of this phenotype. METHODS: The medical records of 296 pediatric onset patients with Crohn's disease, diagnosed from 2001 to 2015, were reviewed retrospectively. Baseline characteristics included age, sex, severity indices, laboratory data, endoscopic findings, and anthropometric measurements...
June 5, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28583256/current-management-of-perianal-crohn-s-disease
#11
Najjia N Mahmoud, Yasmin Halwani, Sandra de Montbrun, Puja M Shah, Traci L Hedrick, Farzana Rashid, David A Schwartz, Robin L Dalal, Jan P Kamiński, Karen Zaghiyan, Phillip R Fleshner, Jason M Weissler, John P Fischer
No abstract text is available yet for this article.
May 2017: Current Problems in Surgery
https://www.readbyqxmd.com/read/28583202/systematic-review-with-meta-analysis-the-efficacy-and-safety-of-stem-cell-therapy-for-crohn-s-disease
#12
REVIEW
Yun Qiu, Man-Ying Li, Ting Feng, Rui Feng, Ren Mao, Bai-Li Chen, Yao He, Zhi-Rong Zeng, Sheng-Hong Zhang, Min-Hu Chen
BACKGROUND AND AIMS: Stem cell therapy (SCT) for the treatment of Crohn's disease (CD) is still in its infancy, and whether SCT is associated with improved outcomes is unclear. We performed a meta-analysis to evaluate the efficacy and safety of patients receiving SCT. METHODS: Electronic databases were searched for studies that reported the use of stem cells for the treatment of patients with CD. Raw data from included studies were pooled for effect estimates. Subgroup analyses were performed for exploration of heterogeneity regarding all outcomes...
June 6, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28573098/axillary-reconstruction-for-hidradenitis-suppurativa-with-an-inner-arm-transposition-flap-creating-a-brachioplasty-effect
#13
Daniel L Ching, Maleeha Mughal, Athanasios Papas, Mark Soldin
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic skin condition that can affect any area with apocrine sweat glands and has the potential to involve multiple sites concurrently. Commonly affected sites include the axilla, groin, perineum and perianal areas. In this study we performed a literature review on the surgical methods for HS and describe an innovative technique for reconstructing axilla HS using an inner-arm transposition flap. METHODS: We reviewed all cases (5 cases from 4 patients) of transposition flap reconstruction performed by the senior author at a single London tertiary hospital from 2008-2013...
May 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28567691/autologous-adipose-tissue-derived-stem-cells-for-the-treatment-of-complex-perianal-fistulas-not-associated-with-crohn-s-disease-a-phase-ii-clinical-trial-for-safety-and-efficacy
#14
S Choi, S-B Ryoo, K J Park, D-S Kim, K-H Song, K H Kim, S S Chung, E J Shin, Y B Cho, S T Oh, W-K Kang, M H Kim
PURPOSE: Injection of adipose tissue-derived stem cells (ASCs) is a novel method for the treatment of complex perianal fistulas. We aimed to evaluate the safety and efficacy of ASCs in the treatment of complex anal fistulas not associated with Crohn's disease. METHODS: A phase II clinical trial was performed comparing two different doses of ASCs (group 1: 1 × 10(7) cells/mL and group 2: 2 × 10(7) cells/mL). Eligible patients were administered an amount of ASCs proportional to the length of the fistula by injection into the submucosal layer surrounding the internal opening and inside of the fistula tract...
May 31, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28567115/factors-associated-with-the-achievement-of-mucosal-healing-in-crohn-s-disease-the-benefit-of-endoscopic-monitoring-in-treating-to-target
#15
Ren Mao, Yun Qiu, Bai-Li Chen, Sheng-Hong Zhang, Rui Feng, Yao He, Zhi-Rong Zeng, Shomron Ben-Horin, Min-Hu Chen
BACKGROUND: Mucosal healing (MH), the proposed treat to target in Crohn's disease (CD), is associated with improved disease outcomes. There are still scant data on factors associated with achieving MH in clinical practice. We evaluated the probability of achieving MH and identified factors predictive of subsequent MH in patients with CD. METHODS: This was a retrospective, observational cohort study. A total of 272 patients with CD with serial endoscopy assessment and subsequent therapeutic management were reviewed...
June 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28566057/sinecatechins-and-imiquimod-as-proactive-sequential-therapy-of-external-genital-and-perianal-warts-in-adults
#16
Helmut Schöfer, Silvio Tatti, Charles W Lynde, Mihael Skerlev, Jana Hercogová, Maria Rotaru, Juan Ballesteros, Piergiacomo Calzavara-Pinton
This review about the proactive sequential therapy (PST) of external genital and perianal warts (EGW) is based on the most current available clinical literature and on the broad clinical experience of a group of international experts, physicians who are well versed in the treatment of human papillomavirus-associated diseases. It provides a practical guide for the treatment of EGW, including epidemiology, etiology, clinical appearance, and diagnostic procedures for these viral infections. Furthermore, the treatment goals and current treatment options, elucidating provider- and patient-applied therapies, and the parameters driving treatment decisions are summarized...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28562531/widely-differing-screening-and-treatment-practice-for-osteoporosis-in-patients-with-inflammatory-bowel-diseases-in-the-swiss-ibd-cohort-study
#17
Solvey Schüle, Jean-Benoît Rossel, Diana Frey, Luc Biedermann, Michael Scharl, Jonas Zeitz, Natália Freitas-Queiroz, Thomas Kuntzen, Thomas Greuter, Stephan R Vavricka, Gerhard Rogler, Benjamin Misselwitz
Low bone mineral density (BMD) and osteoporosis remain frequent problems in patients with inflammatory bowel diseases (IBDs). Several guidelines with nonidentical recommendations exist and there is no general agreement regarding the optimal approach for osteoporosis screening in IBD patients. Clinical practice of osteoporosis screening and treatment remains insufficiently investigated.In the year 2014, a chart review of 877 patients included in the Swiss IBD Cohort study was performed to assess details of osteoporosis diagnostics and treatment...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28552901/the-impact-of-obesity-on-the-clinical-course-of-inflammatory-bowel-disease-a-meta-analysis
#18
Qiongyuan Hu, Jianan Ren, Guanwei Li, Xiuwen Wu, Jieshou Li
BACKGROUND Obesity has been linked with a pro-inflammatory state and the development of inflammatory diseases, including inflammatory bowel disease (IBD). However, there is some controversy regarding whether obesity is associated with an adverse clinical course in patients with IBD. The aim of this meta-analysis was to assess the association between obesity and clinical outcomes in IBD patients. MATERIAL AND METHODS Electronic databases (PubMed, Embase, Cochrane Library, and Web of Science) were systematically searched for studies investigating the association between obesity and clinical outcomes in patients with IBD...
May 29, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28550490/the-use-of-temporary-fecal-diversion-in-colonic-and-perianal-crohn-s-disease-does-not-improve-outcomes
#19
Andrea C Bafford, Anastasiya Latushko, Natasha Hansraj, Guruprasad Jambaulikar, Leyla J Ghazi
AIMS: To determine whether temporary fecal diversion for refractory colonic and/or perianal Crohn's disease can lead to clinical remission and restoration of intestinal continuity after optimization of medical therapy. METHODS: We retrospectively reviewed our prospectively maintained database of patients treated at the University of Maryland for Crohn's disease between May 2004 and July 2014. Patients with colonic, perianal, or colonic and perianal Crohn's disease, who had fecal diversion for control of medically refractory and/or severe disease, were included...
May 26, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28547648/clinical-and-phenotypic-differences-in-inflammatory-bowel-disease-among-arab-and-jewish-children-in-israel
#20
Firas Rinawi, Amit Assa, Husam Bashir, Sarit Peleg, Raanan Shamir
BACKGROUND: Data on inflammatory bowel disease (IBD) phenotypes among the Arab population in Israel or in the neighboring Arab countries is scarce. AIM: We aimed to assess differences in disease phenotype among Arab and Jewish children living in Israel. METHODS: We performed a retrospective chart review of pediatric IBD cases, which were diagnosed at the Schneider Children's Medical Center and Ha'Emek Medical Center in Israel between 2000 and 2014...
May 25, 2017: Digestive Diseases and Sciences
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