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https://www.readbyqxmd.com/read/28351088/premature-progesterone-rise-positively-correlates-with-clinical-pregnancy-rate-in-in-vitro-fertilization-ivf-and-intracytoplasmic-sperm-injection-icsi-patients-with-good-ovarian-response
#1
Na Cui, Jie Zhang, Yueming Xu, Lei Jiang, Aimin Yang, Guimin Hao
Infertility affects millions of couples worldwide resulting in distress and depression. In the past several decades, in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) have been developed with high efficiency and success rate. The possible effects of gonadotropin administration on follicular metabolism have been discussed but the outcomes remain controversial. The aim of this study was to identify whether serum progesterone on the day of human chorionic gonadotropin (hCG) administration and the ratio of serum progesterone and the number of oocyte retrieved (P/O) had a predictive role for the outcomes of IVF/ICSI...
March 28, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28350993/convergent-strategy-for-the-synthesis-of-s-linked-oligoxylans
#2
Beatrice Bonora, Irene Boos, Mads H Clausen
Arabinoxylans (AX) are a major class of hemicellulose and an important polysaccharide component of lignocellulosic biomass. To utilize the glycan polymer effectively, it is desirable to learn more about the enzymatic hydrolysis of AXs. Well-defined glycans can help to elucidate these processes. Here, we report the efficient synthesis of a mixed O- and S-linked tetraxylan. This thio-oligosaccharide has been developed as a putative inhibitor of arabinoxylan degrading enzymes used for the saccharification of biomass...
March 21, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28350962/multi-dimensional-hybridization-of-dark-surface-plasmons
#3
Andrew B Yankovich, Ruggero Verre, Erik Olsén, Anton E O Persson, Viet Trinh, Gudrun Dovner, Mikael Käll, Eva Olsson
Synthetic three-dimensional nano-architectures are providing more control over light-matter interactions and rapidly progressing photonic based technology. These applications often utilize the strong synergy between electromagnetic fields and surface plasmons (SPs) in metallic nanostructures. However, many of the SP interactions hosted by complex 3D nanostructures are poorly understood because they involve dark hybridized states that are typically undetectable with far-field optical spectroscopy. Here, we use experimental and theoretical electron energy loss spectroscopy (EELS) to elucidate dark SPs and their interactions in layered metal-insulator-metal disc nanostructures...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28350931/retained-lumbar-catheter-tip
#4
John O DeLancey, Cynthia Barnard, Karl Y Bilimoria
No abstract text is available yet for this article.
March 28, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28350851/alcohol-related-changes-in-the-intestinal-microbiome-influence-neutrophil-infiltration-inflammation-and-steatosis-in-early-alcoholic-hepatitis-in-mice
#5
Patrick P Lowe, Benedek Gyongyosi, Abhishek Satishchandran, Arvin Iracheta-Vellve, Aditya Ambade, Karen Kodys, Donna Catalano, Doyle V Ward, Gyongyi Szabo
BACKGROUND: Alcohol-induced intestinal dysbiosis disrupts homeostatic gut-liver axis function and is essential in the development of alcoholic liver disease. Here, we investigate changes in enteric microbiome composition in a model of early alcoholic steatohepatitis and dissect the pathogenic role of intestinal microbes in alcohol-induced liver pathology. MATERIALS AND METHODS: Wild type mice received a 10-day diet that was either 5% alcohol-containing or an isocaloric control diet plus a single binge...
2017: PloS One
https://www.readbyqxmd.com/read/28350849/science-deserves-to-be-judged-by-its-contents-not-by-its-wrapping-revisiting-seglen-s-work-on-journal-impact-and-research-evaluation
#6
Lin Zhang, Ronald Rousseau, Gunnar Sivertsen
The scientific foundation for the criticism on the use of the Journal Impact Factor (JIF) in evaluations of individual researchers and their publications was laid between 1989 and 1997 in a series of articles by Per O. Seglen. His basic work has since influenced initiatives such as the San Francisco Declaration on Research Assessment (DORA), the Leiden Manifesto for research metrics, and The Metric Tide review on the role of metrics in research assessment and management. Seglen studied the publications of only 16 senior biomedical scientists...
2017: PloS One
https://www.readbyqxmd.com/read/28350828/clustering-of-four-major-lifestyle-risk-factors-among-korean-adults-with-metabolic-syndrome
#7
Shin Ha, Hui Ran Choi, Yo Han Lee
The purpose of this study was to investigate the clustering pattern of four major lifestyle risk factors-smoking, heavy drinking, poor diet, and physical inactivity-among people with metabolic syndrome in South Korea. There were 2,469 adults with metabolic syndrome aged 30 years or older available with the 5th Korean National Health and Nutrition Examination Survey dataset. We calculated the ratio of the observed to expected (O/E) prevalence for the 16 different combinations and the prevalence odds ratios (POR) of four lifestyle risk factors...
2017: PloS One
https://www.readbyqxmd.com/read/28350778/pediatric-rehabilitation-services-for-children-with-cerebral-palsy-what-can-existing-data-sources-tell-us
#8
Mary E Gannotti, Amy Bailes, Kristie Bjornson, Maggie OʼNeil, Marybeth Grant-Buettler, Stacey Dusing
Knowledge about associated service utilization patterns and positive outcomes in children with cerebral palsy (CP) of varying levels of severity is a national priority. Families, clinicians, program directors, and policy makers need this information for clinical decision-making and service planning. Existing data sources in the United States that contain information about children with CP, their health, function, well being, and utilization of health services may add to our existing knowledge. We provide a summary of fourteen national, state, and local sources' data: where the data come from, challenges and/or specific considerations when using or accessing information, and specific data elements included...
April 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28350751/time-trends-in-the-epidemiology-and-outcome-of-perianal-fistulizing-crohn-s-disease-in-a-population-based-cohort
#9
Kevin W A Göttgens, Steven F G Jeuring, Rosel Sturkenboom, Mariëlle J L Romberg-Camps, Liekele E Oostenbrug, Daisy M A E Jonkers, Laurents P S Stassen, Ad A M Masclee, Marieke J Pierik, Stéphanie O Breukink
OBJECTIVE: Perianal disease is a debilitating condition that frequently occurs in Crohn's disease (CD) patients. It is currently unknown whether its incidence has changed in the era of frequent immunomodulator use and biological availability. We studied the incidence and outcome of perianal and rectovaginal fistulas over the past two decades in our population-based Inflammatory Bowel Disease South-Limburg cohort. PATIENTS AND METHODS: All 1162 CD patients registered in the Inflammatory Bowel Disease South-Limburg registry were included...
May 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28350730/pas-in-orthopedics-in-the-vha-s-community-based-outpatient-clinics
#10
Daniel O Reed, Roderick S Hooker
In the Veterans Health Administration (VHA) system, most orthopedic care takes place in the VA medical centers (VAMCs). Because most patients receiving orthopedic care were referred by adult medicine providers, more widely deploying physician assistants (PAs) in orthopedic medicine might help offset this workload. An orthopedic medicine demonstration project recruited, trained, and positioned PAs in community-based outpatient clinics (CBOCs) to improve access to care. The project involved surgeons at the Houston VAMC instructing five newly employed PAs in a wide range of orthopedic evaluation and management strategies before their assignment to a CBOC...
April 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28350640/in-class-active-videogame-supplementation-and-adherence-to-cardiac-rehabilitation
#11
Jorge Manuel Arsénio Dos Santos Ruivo, Kay Karim, Roisin OʼShea, Rosa Celeste Santos Oliveira, Louis Keary, Claire OʼBrien, John Patrick Gormley
PURPOSE: The application of active videogames (AVGs) during cardiac rehabilitation (CR) sessions could potentially facilitate patient adherence. The feasibility, safety, and efficacy of in-class AVG supplementation as an alternative to conventional phase 2 programs were investigated. METHODS: A pilot, evaluator-blinded, intention-to-treat, randomized controlled trial recruited 32 low-moderate risk CR participants and allocated them to conventional or AVG-supplemented exercise...
March 24, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28350638/short-term-impact-of-meaningful-use-stage-1-implementation-a-comparison-of-health-outcomes-in-2-primary-care-clinics
#12
Anna M Afonso, Susana Alfonso, Toyosi O Morgan
We studied a primary care clinic transitioning to Meaningful Use stage 1 and a comparison clinic within the same health system. In the 6 months following implementation, after adjusting for confounders, mean systolic blood pressure worsened (+3.3 mm Hg; P = .004) in the intervention clinic compared with the comparison clinic. We did not see a change in the mean or proportion of patients meeting target goals for diabetes (hemoglobin A1c) or obesity (body mass index). Our findings suggest that the worsening of systolic blood pressure associated with Meaningful Use implementation is likely due to distractions of system changes negatively impacting health outcomes...
March 27, 2017: Journal of Ambulatory Care Management
https://www.readbyqxmd.com/read/28350632/30-day-readmission-after-spine-surgery-an-analysis-of-1400-consecutive-spine-surgery-patients
#13
Owoicho Adogwa, Aladine A Elsamadicy, Jing L Han, Isaac O Karikari, Joseph Cheng, Carlos A Bagley
STUDY DESIGN: Retrospective cohort review. OBJECTIVE: To identify the rates, causes, and risk factors for 30-day unplanned readmissions in after elective spine surgery at our institution. SUMMARY OF BACKGROUND DATA: Early readmission after spine surgery is being used as a proxy for quality of care. One-fifth of patients are rehospitalized within 30 days after spine surgery. Nearly 60% of these readmissions are unplanned, which translates into billions of dollars in healthcare costs...
April 1, 2017: Spine
https://www.readbyqxmd.com/read/28350568/reducing-length-of-stay-using-a-robotic-assisted-approach-for-retromuscular-ventral-hernia-repair-a-comparative-analysis-from-the-americas-hernia-society-quality-collaborative
#14
Alfredo M Carbonell, Jeremy A Warren, Ajita S Prabhu, Conrad D Ballecer, Randy J Janczyk, Javier Herrera, Li-Ching Huang, Sharon Phillips, Michael J Rosen, Benjamin K Poulose
OBJECTIVE: The aim of this study was to compare length of stay (LOS) after robotic-assisted and open retromuscular ventral hernia repair (RVHR). BACKGROUND: RVHR has traditionally been performed by open techniques. Robotic-assisted surgery enables surgeons to perform minimally invasive RVHR, but with unknown benefit. Using real-world evidence, this study compared LOS after open (o-RVHR) and robotic-assisted (r-RVHR) approach. METHODS: Multi-institutional data from patients undergoing elective RVHR in the Americas Hernia Society Quality Collaborative between 2013 and 2016 were analyzed...
March 27, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28350553/impact-of-allogeneic-hematopoietic-stem-cell-transplantation-on-the-hiv-reservoir-and-immune-response-in-three-hiv-infected-individuals
#15
K K Koelsch, T A Rasmussen, W J Hey-Nguyen, C Pearson, Y Xu, M Bailey, K H Marks, S C Sasson, M S Taylor, R Tantau, S Obeid, B Milner, C O Morrissey, A N Pinto, K Suzuki, M P Busch, S M Keating, P Kaiser, S Yukl, J K Wong, B M Hiener, S Palmer, J Zaunders, J J Post, D J Chan, S Avery, S T Milliken, A D Kelleher, S R Lewin, D A Cooper
BACKGROUND: Allogeneic hematopoietic stem cell transplantation (HSCT) can lead to significant changes to the HIV reservoir and HIV immune responses, indicating that further characterisation of HIV infected patients undergoing HSCT is warranted. METHODS: We studied three patients who underwent HSCT after either reduced intensity conditioning or myeloablative conditioning regimen. We measured HIV antigens and antibodies (Ag/Ab), HIV specific CD4+ T cell responses, HIV RNA and DNA in plasma, peripheral blood mononuclear cells (PBMCs), isolated CD4+ T cells from peripheral blood and lymph node cells...
March 24, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28350546/comparing-stochastic-proton-interactions-simulated-using-topas-nbio-to-experimental-data-from-fluorescent-nuclear-track-detectors
#16
T S A Underwood, W Sung, C H McFadden, S J McMahon, D C Hall, A L McNamara, H Paganetti, G O Sawakuchi, J Schuemann
Whilst Monte Carlo (MC) simulations of proton energy deposition have been well-validated at the macroscopic level, their microscopic validation remains lacking. Equally, no gold-standard yet exists for experimental metrology of individual proton tracks. In this work we compare the distributions of stochastic proton interactions simulated using the TOPAS-nBio MC platform against confocal microscope data for Al2O3:C,Mg fluorescent nuclear track detectors (FNTDs). We irradiated [Formula: see text] mm(3) FNTD chips inside a water phantom, positioned at seven positions along a pristine proton Bragg peak with a range in water of 12 cm...
April 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28350531/phytophthora-infestans-effectors-ipi-o1-and-ipi-o4-each-contribute-to-pathogen-virulence
#17
Yu Chen, Dennis A Halterman
Potato late blight, caused by the oomycete pathogen Phytophthora infestans, is one of the most destructive plant diseases. Despite decades of intensive breeding efforts, it remains a threat to potato production worldwide, because newly evolved pathogen strains have overcome major resistance genes quickly. The RB protein, from the diploid wild potato species Solanum bulbocastanum, confers partial resistance to most P. infestans strains through its recognition of members of the corresponding pathogen effector protein family IPI-O...
March 29, 2017: Phytopathology
https://www.readbyqxmd.com/read/28350449/long-chained-4-aminoquinolines-as-quorum-sensing-inhibitors-in-serratia-marcescens-and-pseudomonas-aeruginosa
#18
Ivana Aleksić, Sandra Šegan, Filip Andric, Mario Zlatović, Ivana Moric, Dejan M Opsenica, Lidija Senerovic
Antibiotic resistance has become serious global threat to public health; therefore, the improved strategies and structurally novel antimicrobials are urgently needed to combat infectious diseases. Here we report a new type of highly potent 4-aminoquinoline derivatives as quorum sensing inhibitors in Serratia marcescens and Pseudomonas aeruginosa, exhibiting weak bactericidal activities (MIC > 400 μM). Through detailed structure-activity study we have identified 7-Cl and 7-CF3 substituted N-dodecylamino-4-aminoquinolines (5 and 10) as biofilm formation inhibitors with 50% biofilm inhibition at 69 μM and 63 μM in S...
March 28, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28350445/structural-changes-in-an-anion-channelrhodopsin-formation-of-the-k-and-l-intermediates-at-80-k
#19
Adrian Yi, Hai Li, Natalia V Mamaeva, Roberto F de Cordoba, Johan Lugtenburg, Willem J DeGrip, John L Spudich, Kenneth J Rothschild
A recently discovered natural family of light-gated anion channelrhodopsins (ACRs) from cryptophyte algae provides an effective means of optogenetically silencing neurons. The most extensively studied ACR is from Guillardia theta (GtACR1). Earlier studies of GtACR1 have established a correlation between formation of a blue-shifted L-like intermediate and the anion channel "open" state. To study structural changes of GtACR1 in the K and L intermediates of the photocycle, a combination of low-temperature FTIR and UV-visible absorption difference spectroscopy was used along with stable-isotope retinal labeling and site-directed mutagenesis...
March 28, 2017: Biochemistry
https://www.readbyqxmd.com/read/28346994/gc-ms-analysis-and-potential-cytotoxic-activity-of-calyptranthes-grandifolia-o-berg-calyptranthes-tricona-d-legrand-and-myrciaria-plinioides-d-legrand-essential-oil-in-raw264-7-and-cho-k1-cells
#20
D Faleiro, S M Immich, F Majolo, L Mayer, E M Ethur, M I Goettert
The search for new bioactive substances derived from natural products is daily growing. Among biologically active products used in therapeutic approaches, essential oils are described with wide range of therapeutic and pharmacological potential. Plants from Myrtaceae family have the presence of essential oils in its composition. Calyptranthes grandifolia, Calyptranthes tricona and Myrciaria plinioides species belong to this family and are used by the local population. However, there are no reports in the literature describing relevant characteristics about the potential and possible activities of these species...
March 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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