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https://www.readbyqxmd.com/read/28931170/strengthening-teachers-abilities-to-implement-a-vision-health-program-in-taiwanese-schools
#1
L C Chang, L L Liao, M I Chen, Y Z Niu, P L Hsieh
We designed a school-based, nationwide program called the 'New Era in Eye Health' to strengthen teacher training and to examine whether the existence of a government vision care policy influenced teachers' vision care knowledge and students' behavior. Baseline data and 3-month follow-up data were compared. A random sample of teachers (n = 660) from school vision health clusters in 22 cities/counties in Taiwan were invited to participate in our study and 436 agreed to participate (response rate = 66.1%). The mean age of participant teachers was 41...
October 1, 2017: Health Education Research
https://www.readbyqxmd.com/read/28931158/new-mitogenomes-of-two-chinese-stag-beetles-coleoptera-lucanidae-and-their-implications-for-systematics
#2
Zi-Qi Lin, Fan Song, Teng Li, Yuan-Yuan Wu, Xia Wan
Although conspicuous and well-studied, stag beetles have been slow to join the genomic era. In this study, mitochondrial genomes of two stag beetles, Sinodendron yunnanense and Prosopocoilus confucius, are sequenced for the first time. Both of their genomes consisted of 13 protein-coding genes (PCGs), 22 transfer RNA genes (tRNAs), 2 ribosomal RNAs (rRNAs), and a control region. The mitogenome of S. yunnanense was 16,921 bp in length, and P. confucius was 16,951 bp. The location of the gene trnL(UUR), between the A + T-rich and control region in S...
January 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28930992/a-cell-culture-model-of-resistance-arteries
#3
Lauren A Biwer, Christophe Lechauve, Sheri Vanhoose, Mitchell J Weiss, Brant E Isakson
The myoendothelial junction (MEJ), a unique signaling microdomain in small diameter resistance arteries, exhibits localization of specific proteins and signaling processes that can control vascular tone and blood pressure. As it is a projection from either the endothelial or smooth muscle cell, and due to its small size (on average, an area of ~1 µm(2)), the MEJ is difficult to study in isolation. However, we have developed a cell culture model called the vascular cell co-culture (VCCC) that allows for in vitro MEJ formation, endothelial cell polarization, and dissection of signaling proteins and processes in the vascular wall of resistance arteries...
September 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28930774/high-levels-of-cerebrospinal-fluid-chemokines-point-to-the-presence-of-neuroinflammation-in-peripheral-neuropathic-pain-a-cross-sectional-study-of-two-cohorts-of-patients-compared-to-healthy-controls
#4
Emmanuel Bäckryd, Anne-Li Lind, Måns Thulin, Anders Larsson, Björn Gerdle, Torsten Gordh
Animal models suggest that chemokines are important mediators in the pathophysiology of neuropathic pain. Indeed, these substances have been called "gliotransmitters", a term that illustrates the close interplay between glial cells and neurons in the context of neuroinflammation and pain. However, evidence in humans is scarce. The aim of the study was to determine a comprehensive cerebrospinal fluid (CSF) inflammatory profile for neuropathic pain patients. Our hypothesis was that we would thereby find indications of a postulated on-going process of central neuroinflammation...
September 18, 2017: Pain
https://www.readbyqxmd.com/read/28930762/competency-based-medical-education-in-the-internal-medicine-clerkship-a-report-from-the-alliance-for-academic-internal-medicine-undergraduate-medical-education-task-force
#5
Sara B Fazio, Cynthia H Ledford, Paul B Aronowitz, Shobhina G Chheda, John H Choe, Stephanie A Call, Scott D Gitlin, Marty Muntz, L James Nixon, Anne G Pereira, John W Ragsdale, Emily A Stewart, Karen E Hauer
As medical educators continue to redefine learning and assessment across the continuum, implementation of competency-based medical education in the undergraduate setting has become a focus of many medical schools. While standards of competency have been defined for the graduating student, there is no uniform approach for defining competency expectations for students during their core clerkship year. The authors describe the process by which an Alliance for Academic Internal Medicine task force developed a paradigm for competency-based assessment of students during their inpatient internal medicine (IM) clerkship...
September 14, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28930704/holding-ashley-x-bestowing-identity-through-caregiving-in-profound-intellectual-disability
#6
Lisa Freitag, Joan Liaschenko
The controversy over the so-called Ashley Treatment (AT), a series of medical procedures that inhibited both growth and sexual development in the body of a profoundly intellectually impaired girl, usually centers either on Ashley's rights, including a right to an intact, unaltered body, or on Ashley's parents' rights to make decisions for her. The claim made by her parents, that the procedure would improve their ability to care for her, is often dismissed as inappropriate or, at best, irrelevant. We argue, however, that caregiving is a central issue in the controversy, as Ashley's need for caregiving is a defining characteristic of her life...
2017: Journal of Clinical Ethics
https://www.readbyqxmd.com/read/28930561/immune-ligands-for-cytotoxic-t-lymphocytes-ctls-in-cancer-stem-cells-cscs
#7
Ioannis A Voutsadakis
   The immune system has come to the forefront of cancer therapeutics in recent years with the success of immune blockade inhibitors in a variety of cancers whose list is increasing with a quick pace. Despite the efficacy of these drugs across a significant part of the cancer spectrum, responses are still seen only in a minority of patients, that implies that most patients are refractory or promptly develop resistance to these agents. Mechanisms of this resistance are important to decipher as this knowledge may lead to the introduction of additional therapies or manipulations to modulate resistance...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930535/leader-sequences-of-coronavirus-are-altered-during-infection
#8
Li Liu, Wei Chen
The life cycle of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) involves a unique process called discontinuous transcription by which a set of 3' coterminal subgenomic mRNAs (sgmRNA) with identical 5' leader sequences can be generated. The current study demonstrates that the replication intermediates of minus strand of subgenomic RNA (sgRNA) can be readily recovered from SARS-CoV infected cells. A novel sgmRNA (M-1) was identified as a short version of membrane (M) gene. Transcriptional regulatory sequences (TRS) of SARS-CoV and Mouse Hepatitis Virus (MHV) sgmRNAs contain a species specific core element (CE)...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930498/molecular-and-morphological-characterization-of-a-brazilian-lineage-of-plasmodium-novyella-unalis-in-turdus-spp-passeriformes-of-the-atlantic-forest-with-remarks-on-new-hosts-and-high-genetic-variation
#9
Raquel Tostes, Roberto Júnio Pedroso Dias, Luísa de Oliveira, Marcus Vinicius Xavier Senra, Carlos Luiz Massard, Marta D'Agosto
Plasmodium spp. are haemosporidian protozoans that alternate their live cycles between bloodsucking Culicidae dipterans and vertebrate hosts (mammals, reptiles and birds). In birds, these parasites are the causative agents of the so called avian malaria, a disease associated with considerable declines and extinctions in the avifauna in different geographical regions. In this work, we applied a multidisciplinary approach, light microscopy and cytochrome oxidase b (cyt b) gene sequence analysis for characterization of Plasmodium found in association with wild birds of the genus Turdus, collected in Atlantic forest fragments of southeastern Brazil...
September 20, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28930154/autophagy-and-inflammatory-response-in-the-tumor-microenvironment
#10
REVIEW
Daniel Ngabire, Gun-Do Kim
Cell death is the last fate of the life cycle of cells. Different pathways involved in cell death are known to date, and are mostly represented by apoptosis, necrosis, and autophagy. Autophagy is one of the most preserved cell death pathways, characterized by the elimination of large parts of cytoplasmic components after being consumed by a double-membraned vesicle called an autophagosome. The formed autophagosome then fuses with a lysosome containing degrading enzymes and leads to the digestion of the autophagosome content...
September 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28930140/identification-of-phlogacantholide-c-as-a-novel-adam10-enhancer-from-traditional-chinese-medicinal-plants
#11
Myriam Meineck, Florian Schuck, Sara Abdelfatah, Thomas Efferth, Kristina Endres
Background: Alzheimer's disease is one of the most prevalent dementias in the elderly population with increasing numbers of patients. One pivotal hallmark of this disorder is the deposition of protein aggregates stemming from neurotoxic amyloid-beta peptides. Synthesis of those peptides has been efficiently prevented in AD model mice by activation of an enzyme called alpha-secretase. Therefore, drugs with the capability to increase the expression of this enzyme, named ADAM10, have been suggested as a valuable therapeutic medication...
December 5, 2016: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28929970/bayesian-unidimensional-scaling-for-visualizing-uncertainty-in-high-dimensional-datasets-with-latent-ordering-of-observations
#12
Lan Huong Nguyen, Susan Holmes
BACKGROUND: Detecting patterns in high-dimensional multivariate datasets is non-trivial. Clustering and dimensionality reduction techniques often help in discerning inherent structures. In biological datasets such as microbial community composition or gene expression data, observations can be generated from a continuous process, often unknown. Estimating data points' 'natural ordering' and their corresponding uncertainties can help researchers draw insights about the mechanisms involved...
September 13, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28929934/call-for-papers-special-issue-on-mental-health-in-the-nordic-countries
#13
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28929862/the-accuracy-of-the-computed-tomography-diagnosis-of-acute-appendicitis-does-the-experience-of-the-radiologist-matter
#14
E Lietzén, P Salminen, I Rinta-Kiikka, H Paajanen, T Rautio, P Nordström, M Aarnio, T Rantanen, J Sand, J-P Mecklin, A Jartti, J Virtanen, P Ohtonen, N Ånäs, J M Grönroos
BACKGROUND AND AIMS: To assess the accuracy of computed tomography in diagnosing acute appendicitis with a special reference to radiologist experience. MATERIAL AND METHODS: Data were collected prospectively in our randomized controlled trial comparing surgery and antibiotic treatment for uncomplicated acute appendicitis (APPAC trial, NCT01022567). We evaluated 1065 patients who underwent computed tomography for suspected appendicitis. The on-call radiologist preoperatively analyzed these computed tomography images...
September 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/28929852/the-ethics-of-genome-editing-in-the-clinic-a-dose-of-realism-for-healthcare-leaders
#15
Tania Bubela, Yael Mansour, Dianne Nicol
Genome editing technologies promise therapeutic advances for genetic diseases. We discuss the ethical and societal issues raised by these technologies, including their use in preclinical research, their potential to address mutations in somatic cells, and their potential to make germ line alterations that may be passed to subsequent generations. We call for a proportionate response from health leaders based on a realistic assessment of benefits, risks, and timelines for clinical translation.
May 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28929837/a-review-of-the-historical-criminological-and-theoretical-understandings-of-the-cambodian-american-population-a-call-for-more-comprehensive-research
#16
Dany Chheang, Eric J Connolly
The collective view of Asian Americans as model minorities is evident with the extensive amount of statistical data showing support for the academic and socioeconomic success of Asian Americans in the United States. This perception, however, often presents an inaccurate portrayal of Asian Americans, in general, as it overlooks many of the difficulties and hardships experienced by Asian American ethnic groups such as Southeast Asians. Within this group, Cambodian Americans are at the highest risk for experiencing socioeconomic hardships, behavioral health problems, substance use disorders, and contact with the criminal justice system, with deportation also being a prevailing issue...
September 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/28929815/the-challenge-of-curbing-aminoglycoside-resistance-can-antimicrobial-stewardship-programs-play-a-critical-role
#17
Vassiliki Pitiriga, Evangelia Dimitroulia, George Saroglou, Athanassios Tsakris
Aminoglycosides are useful antimicrobials, primarily for serious infections involving aerobic gram-negative pathogens. The inevitable increase in aminoglycoside resistance has led to calls for reducing levels of inappropriate aminoglycoside prescribing through the implementation of various antibiotic stewardship programs (ASPs). These programs mainly include restriction policies and aminoglycoside cycling. Although aminoglycoside resistance rates appear essential for measuring effectiveness of these interventions, most studies have focused on economic outcomes or clinical efficacy and toxicities...
September 20, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28929742/beta-hemolytic-bacteria-selectively-trigger-liposome-lysis-enabling-rapid-and-accurate-pathogen-detection
#18
Rongji Sum, Muthukaruppan Swaminathan, Sahil Kumar Rastogi, Obdulio Piloto, Ian Cheong
For more than a century, blood agar plates have been the only test for beta-hemolysis. Although blood agar cultures are highly predictive for bacterial pathogens, they are too slow to yield actionable information. Here, we show that beta-hemolytic pathogens are able to lyse and release fluorophores encapsulated in sterically stabilized liposomes whereas alpha and gamma-hemolytic bacteria have no effect. By analyzing fluorescence kinetics, beta-hemolytic colonies cultured on agar could be distinguished in real time with 100% accuracy within 6 h...
September 20, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28929726/-factors-associated-to-medical-visits-comparison-among-italians-and-immigrants-resident-in-italy
#19
Anteo Di Napoli, Monica Perez, Alessandra Rossi, Daniele Spizzichino, Laura Iannucci, Lidia Gargiulo, Daniela Panaccione, Concetta Mirisola, Alessio Petrelli
OBJECTIVES: to evaluate the role of factors potentially associated with the use of medical visits by the immigrant population living in Italy, making a comparison with the Italian population. DESIGN: cross-sectional study based on the representative sample of the population residing in Italy considered in the Survey "Health and use of health services" conducted by the Italian National Institute of Statistics (Istat) in 2013. SETTING AND PARTICIPANTS: the study was conducted on a sample of citizens aged 18-64 years (72,476 individuals) representing a population of 37,290,440 residents in Italy (33...
May 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28929549/uplc-qtof-ms-e-based-diagnostic-product-ion-filtering-to-unveil-unstable-c6-c2-glucoside-conjugates-in-forsythia-suspensa
#20
Yong-Gang Xia, Jun Liang, Xin-Dong Guo, Hui-Min Sun, Hai-Xue Kuang
Forsythia suspensa contains C6 -C2 glucoside conjugates (CCGCs) that are chemically unstable, thereby hindering their isolation and purification. In the present study, ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF) was utilized to screen and identify unstable CCGCs in the fruits and leaves of F. suspensa without any tedious isolation and purified process based on independent information acquisition (also called MS(E) ) and individual MS/MS experiments. Diagnostic product ion filtering (DPIF) was further applied to mine unknown analogs in MS(E) high energy levels based on characteristic m/z of key substructures...
September 20, 2017: Journal of Mass Spectrometry: JMS
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