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Acute Kidney Injury Biomarkers

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https://www.readbyqxmd.com/read/29145491/the-urine-biomarker-panel-igfbp7-x-timp-2-nephrocheck%C3%A2-parameter-does-not-correlate-with-igfbp7-and-timp-2-gene-expression-in-urinary-sediment
#1
Daniela Knafl, Markus Müller, Sahra Pajenda, Zeynep Genc, Manfred Hecking, Ludwig Wagner
BACKGROUND: Acute kidney injury (AKI) is frequently observed in serious infections, following nephrotoxic medication, surgery and trauma. Here we tested whether the detection of two recently identified biomarkers for AKI, Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) and Insulin-Like Growth Factor Binding Protein 7 (IGFBP7), depends on the expression of these proteins in cells of the urinary sediment. METHOD: We collected urine samples of 33 kidney transplant recipients and 14 non-transplanted patients who all had AKI (stages 1-3 according to KDIGO), and measured [IGFBP7]x[TIMP-2] using the NephroCheck® Astute1 40 ™ meter...
2017: PloS One
https://www.readbyqxmd.com/read/29135142/-investigation-of-serum-cysteine-concentration-to-monitor-glomerular-filtration-rate-for-early-diagnosis-of-acute-kidney-injury-in-patients-with-combined-trauma
#2
I A Miziev, M Kh Makhov
AIM: / To determine the early diagnostic criteria for acute kidney injury in patients with combined trauma using serum cystatin C as a biomarker in the diagnostic work-up of the affected patients. MATERIALS AND METHODS: / The study comprised 42 patients who suffered combined trauma from 2015 to 2016. Cystatin C level was measured in serum. Blood sampling was done on the 1st, 3rd, 7th, 14th day of the injury. The patients were predominantly men (80%). Renal function was tested by measuring the rate of filtration and reabsorption using the Reberg-Tareev test...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29133918/fast-simultaneous-assessment-of-renal-and-liver-function-using-polymethine-dyes-in-animal-models-of-chronic-and-acute-organ-injury
#3
A T Press, M J Butans, T P Haider, C Weber, S Neugebauer, M Kiehntopf, U S Schubert, M G Clemens, M Bauer, A Kortgen
Simultaneous assessment of excretory liver and kidney function is still an unmet need in experimental stress models as well as in critical care. The aim of the study was to characterize two polymethine-dyes potentially suitable for this purpose in vivo. Plasma disappearance rate and elimination measurements of simultaneously injected fluorescent dyes DY-780 (hepato-biliary elimination) and DY-654(renal elimination) were conducted using catheter techniques and intravital microscopy in animals subjected to different organ injuries, i...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29126144/multi-scale-mathematical-model-of-drug-induced-proximal-tubule-injury-linking-urinary-biomarkers-to-epithelial-cell-injury-and-renal-dysfunction
#4
Yeshitila Gebremichael, James Lu, Harish Shankaran, Gabriel Helmlinger, Jerome Mettetal, K Melissa Hallow
Drug-induced nephrotoxicity is a major cause of acute kidney injury (AKI), and thus detecting the potential for nephrotoxicity early in the drug development process is critical. Various urinary biomarkers exhibit different patterns following drug-induced injury that may provide greater information than traditional biomarkers like serum creatinine. In this study, we developed a multi-scale quantitative systems pharmacology model relating drug exposure to proximal tubule (PT) epithelial cell injury, and subsequently to expression of multiple urinary biomarkers and organ-level functional changes...
November 6, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29119923/drug-induced-nephrotoxicity-pathogenic-mechanisms-biomarkers-and-prevention-strategies
#5
Jiaguo Huang, Huizi Wu
Overdosing of the drugs, drug-drug interaction or drug related adverse effects are the risk factors of drug-induced nephrotoxicity. Since the use of some nephrotoxic drugs is still unavoidable in clinic, to understand the pathogenic mechanisms of nephrotoxicity of these drugs is critical to decrease the incidence of kidney injury. Early detection of drug-induced nephrotoxicity and reduce the therapeutic side effects are still accessible approaches to avoid the end stage of renal failure. Therefore, the discovery or development of the early and accurate diagnostic biomarkers is an effective prevention strategy for drug-induced kidney impairment...
November 8, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29118769/clinical-usefulness-of-urinary-liver-fatty-acid-binding-protein-excretion-for-predicting-acute-kidney-injury-during-the-first-7-days-and-the-short-term-prognosis-in-acute-heart-failure-patients-with-non-chronic-kidney-disease
#6
Akihiro Shirakabe, Noritake Hata, Nobuaki Kobayashi, Hirotake Okazaki, Masato Matsushita, Yusaku Shibata, Suguru Nishigoori, Saori Uchiyama, Kuniya Asai, Wataru Shimizu
Background: The clinical significance of urinary liver fatty acid-binding protein (u-LFABP) in acute heart failure (AHF) patients remains unclear. Methods and Results: The u-LFABP levels on admission of 293 AHF patients were analyzed. The patients were divided into 2 groups according to the u-LFABP quartiles (Q1, Q2, and Q3 = low u-LFABP [L] group vs. Q4 = high u-LFABP [H] group). We evaluated the diagnostic and prognostic value of u-LFABP and compared the findings between the chronic kidney disease (CKD; n = 165) and non-CKD patients (n = 128)...
October 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29118765/urinary-liver-type-fatty-acid-binding-protein-level-as-a-predictive-biomarker-of-acute-kidney-injury-in-patients-with-acute-decompensated-heart-failure
#7
Keiichi Hishikari, Hiroyuki Hikita, Shun Nakamura, Shun Nakagama, Masahumi Mizusawa, Tasuku Yamamoto, Junichi Doi, Yosuke Hayashi, Yuya Utsugi, Makoto Araki, Yuta Sudo, Shigeki Kimura, Atsushi Takahashi, Takashi Ashikaga, Mitsuaki Isobe
Background: There are no biological markers to predict the onset of acute kidney injury (AKI) in patients with acute decompensated heart failure (ADHF). Liver-type fatty acid-binding protein (L-FABP) levels are markedly upregulated in the proximal tubules after renal ischemia. We investigated whether urinary L-FABP is a suitable marker to predict AKI in ADHF patients. Methods: We examined 281 consecutive patients with ADHF. Serum creatinine (Cr) and L-FABP levels were measured at admission and 24 and 48 h after admission...
October 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29110506/mouse-population-based-evaluation-of-urinary-protein-and-mirna-biomarker-performance-associated-with-cisplatin-renal-injury
#8
Alison H Harrill, Haixia Lin, Julia Tobacyk, John C Seely
Discovery and qualification of novel biomarkers with improved specificity and sensitivity for detection of xenobiotic-induced injuries is an area of active research across multiple sectors. However, the majority of efforts in this arena have used genetically limited rodent stocks that lack variability in xenobiotic responses inherent to genetically heterogeneous human populations. In this study, genetically diverse Diversity Outbred (DO) mice were used as a surrogate for human clinical populations to investigate performance of urinary kidney biomarkers against classical preclinical kidney injury biomarkers (blood urea nitrogen [BUN] and serum creatinine)...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29104728/oxidative-stress-and-acute-kidney-injury-in-critical-illness-pathophysiologic-mechanisms-biomarkers-interventions-and-future-perspectives
#9
REVIEW
Paraskevi Pavlakou, Vassilios Liakopoulos, Theodoros Eleftheriadis, Michael Mitsis, Evangelia Dounousi
Acute kidney injury (AKI) is a multifactorial entity that occurs in a variety of clinical settings. Although AKI is not a usual reason for intensive care unit (ICU) admission, it often complicates critically ill patients' clinical course requiring renal replacement therapy progressing sometimes to end-stage renal disease and increasing mortality. The causes of AKI in the group of ICU patients are further complicated from damaged metabolic state, systemic inflammation, sepsis, and hemodynamic dysregulations, leading to an imbalance that generates oxidative stress response...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29101178/heart-functional-and-structural-compendium-of-cardiosplenic-and-cardiorenal-networks-in-acute-and-chronic-heart-failure-pathology
#10
Ganesh V Halade, Vasundhara Kain, Kevin A Ingle
Heart failure (HF) secondary to myocardial infarction (MI) is linked to kidney complications that comprise cellular, structural, functional, and survival indicators. However, the HF research is focused on left ventricle (LV) pathology. Here, we determined the comprehensive functional analysis of LV using echocardiography in transition from acute HF (AHF) to progressive CHF pathology and develop a histological compendium of the cardiosplenic and cardiorenal networks in pathological remodeling. In surgically-induced MI using permanent coronary ligation, the LV dysfunction is pronounced, with myocardium necrosis, wall-thinning and 20-30% LV rupture events that indicated AHF and CHF pathological remodeling in C57BL/6 male mice (2-4 months old; n=50)...
November 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29100016/urinary-versus-plasma-neutrophil-gelatinase-associated-lipocalin-ngal-as-a-predictor-of-mortality-for-acute-kidney-injury-in-intensive-care-unit-patients
#11
Ata Mahmoodpoor, Hadi Hamishehkar, Vahid Fattahi, Sarvin Sanaie, Pradeep Arora, Nader D Nader
OBJECTIVE: To examine urinary and plasma neutrophil gelatinase-associated lipocalin (NGAL) levels in predicting ICU mortality. DESIGN: Prospective observational. SETTING: University Critical Care setting. PARTICIPANTS: 50 patients with acute kidney injury (AKI). INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Serial urinary and plasma concentrations of NGAL were measured...
October 26, 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29098551/ascites-neutrophil-gelatinase-associated-lipocalin-identifies-spontaneous-bacterial-peritonitis-and-predicts-mortality-in-hospitalized-patients-with-cirrhosis
#12
Giuseppe Cullaro, Grace Kim, Marcus R Pereira, Robert S Brown, Elizabeth C Verna
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) is a marker of both tissue injury and infection. Urine NGAL levels strongly predict acute kidney injury and mortality in patients with cirrhosis, but ascites NGAL is not well characterized. We hypothesized that ascites NGAL level is a marker of spontaneous bacterial peritonitis (SBP) and mortality risk in patients with cirrhosis. METHODS: Hospitalized patients with cirrhosis and ascites undergoing diagnostic paracentesis were prospectively enrolled and followed until death or discharge...
November 2, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29077618/urinary-oxygenation-as-a-surrogate-measure-of-medullary-oxygenation-during-angiotensin-ii-therapy-in-septic-acute-kidney-injury
#13
Yugeesh R Lankadeva, Junko Kosaka, Roger G Evans, Rinaldo Bellomo, Clive N May
OBJECTIVES: Angiotensin II is an emerging therapy for septic acute kidney injury, but it is unknown if its vasoconstrictor action induces renal hypoxia. We therefore examined the effects of angiotensin II on intrarenal PO2 in ovine sepsis. We also assessed the validity of urinary PO2 as a surrogate measure of medullary PO2. DESIGN: Interventional study. SETTING: Research Institute. SUBJECTS: Sixteen adult Merino ewes (n = 8/group)...
October 26, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29069419/prediction-of-contrast-induced-acute-kidney-injury-using-novel-biomarkers-following-contrast-coronary-angiography
#14
M Connolly, M Kinnin, D Mc Eneaney, I Menown, M J Kurth, J Lamont, N Morgan, M Harbinson
Background: Chronic Kidney Disease (CKD) is a risk factor for contrast induced acute kidney injury (CI-AKI). Contrast angiography in CKD patients is a common procedure. Creatinine is a delayed marker of CI-AKI and delays diagnosis which results in significant morbidity and mortality. Aim: Early diagnosis of CI-AKI requires validated novel biomarkers. Design: A prospective observation study of 301 consecutive CKD patients undergoing coronary angiography was performed...
October 23, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29058155/preoperative-levels-of-urinary-uromodulin-predict-acute-kidney-injury-after-pediatric-cardiopulmonary-bypass-surgery
#15
Michael R Bennett, Olivia Pyles, Qing Ma, Prasad Devarajan
BACKGROUND: Acute kidney injury (AKI) is a common complication of cardiopulmonary bypass surgery (CPB) in children. Several promising postoperative AKI biomarkers have been identified, but no preoperative biomarkers are available. We evaluated the association of urinary uromodulin (uUMOD) with postoperative AKI. METHODS: One hundred and one children undergoing CPB were enrolled. Urine was collected prior to CPB, and AKI was defined as ≧50% increase in serum creatinine from preoperative baseline within 48 h of surgery...
October 23, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29057384/concise-review-current-and-emerging-biomarkers-of-nephrotoxicity
#16
Elijah J Weber, Jonathan Himmelfarb, Edward J Kelly
The kidney is a primary organ for filtration of the blood and elimination of drugs and xenobiotics. These active reabsorptive and secretory processes can result in acute kidney injury as a result of these concentrative properties. Classic measures of acute kidney injury are hampered by their ability to accurately assess function before irreversible damage has occurred. This review will discuss efforts to refine the clinical utility of standard biomarkers as well as the development of novel biomarkers of nephrotoxicity...
June 2017: Current Opinion in Toxicology
https://www.readbyqxmd.com/read/29056520/characterization-of-immune-cell-endothelial-and-renal-responses-upon-experimental-human-endotoxemia
#17
Eveline P van Poelgeest, Marlous R Dillingh, Marieke de Kam, Karen E Malone, Marleen Kemper, Erik S G Stroes, Jacobus Burggraaf, Matthijs Moerland
INTRODUCTION: Although the effects of relatively high concentrations of endotoxin on endothelial activation/dysfunction and kidney markers has been described in literature, detailed insight in the LPS concentration-effect relationship, the magnitude, variability and timing of the response, and potential effects of endotoxemia on the kidneys is lacking. A study was performed to assess the effects of low- to moderate dose (0.5, 1 or 2ng/kg) endotoxemia on the endothelium and kidneys as measured by a panel of novel highly sensitive kidney injury markers...
October 19, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29056166/long-term-adverse-events-associated-with-acute-kidney-injury
#18
Manisha Singh, Nithin Karakala, Sudhir V Shah
Acute kidney injury (AKI) occurs in approximately 10% to 15% of hospital-admitted patients and is associated with in-hospital mortality of 50% in patients requiring renal replacement therapy. Recently, multiple observational studies have demonstrated that patients who survive AKI have significant long-term consequences including cardiovascular events, progression to advanced-stage chronic kidney disease (CKD), and mortality. A direct link between AKI and CKD is provided by studies that demonstrate that some patients with normal renal function who develop AKI requiring dialysis never recover...
November 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29051111/perspectives-on-using-a-multiplex-human-kidney-safety-biomarker-panel-to-detect-cisplatin-induced-tubular-toxicity-in-male-and-female-cynomolgus-monkeys
#19
Yafei Chen, J Dale Thurman, Lewis B Kinter, Russell Bialecki, J Eric McDuffie
Multiplex biomarker panel assays would enable early de-risking of discovery compound related kidney safety liabilities. The objective of this study was to evaluate the usefulness of the Myriad RBM Human KidneyMAP (Multi-Analyte Profile)® v.1.0 panel to detect experimental nephrotoxicity in Cynomolgus monkeys following a single intravenous administration of cisplatin (2.5mg/kg). Urine samples were collected at baseline on day -2; at approximately 4hr post-dose on day 1; and on days 4, 9, 15 and/or 20. Blood samples were collected at predose on day -2; at 4hr post-dose on day 1; and on days 2, 5, 10 and/or 21...
October 16, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29050002/urinary-erythrocyte-derived-mirnas-emerging-role-in-iga-nephropathy
#20
Zhi-Yu Duan, Guang-Yan Cai, Ji-Jun Li, Ru Bu, Xiang-Mei Chen
Hematuria is one of the basic clinical manifestations of IgA nephropathy (IgAN). Isolated microscopic hematuria or microscopic hematuria combined with proteinuria is risk factor for the long-term prognosis of IgAN. Current evidence of the consequences of glomerular hematuria rests on insights from basic research on the molecular mechanisms of hemoglobin and related reactive oxygen species-induced tubular injury as well as on the clinical evidence of macroscopic hematuria-associated acute kidney injury (AKI) in IgAN...
October 19, 2017: Kidney & Blood Pressure Research
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