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Local anesthetic and children and local anesthetic

https://read.qxmd.com/read/38114607/rescue-designs-in-analgesic-trials-from-0-to-2-years-of-age-scoping-review
#21
REVIEW
Kyra Haskes, Carolina Donado, Ricardo Carbajal, Charles B Berde, Joe Kossowsky
Pediatric analgesic trials are challenging, especially in newborns and infants. Following an FDA-academic consensus meeting, we analyzed pragmatic rescue designs in postoperative trials of local anesthetics, acetaminophen, opioids, and NSAIDs involving children ages 0-2 years and assessed surgical volumes to provide trial design recommendations. Searches of PubMed, Embase, CINAHL, The Cochrane Library, and Web of Science were conducted. A scoping approach identified trends in analgesic trials with an emphasis on randomized controlled trials (RCTs) utilizing immediate rescue designs...
December 19, 2023: Pediatric Research
https://read.qxmd.com/read/38078553/current-pediatric-pain-practice-in-nigeria-south-africa-uganda-and-zambia-a-prospective-survey-of-anesthetists
#22
JOURNAL ARTICLE
Anisa Bhettay, Rebecca Gray, Ibironke Desalu, Romy Parker, Salome Maswime
BACKGROUND: Children in hospital experience significant pain, either inherent with their pathology, or caused by diagnostic/therapeutic procedures. Little is known about pediatric pain practices in sub-Saharan Africa. This survey aimed to gain insight into current pain management practices among specialist physician anesthetists in four sub-Saharan African countries. METHODS: A survey was sent to 365 specialist physician anesthetists in Nigeria, South Africa, Uganda and Zambia...
December 11, 2023: Paediatric Anaesthesia
https://read.qxmd.com/read/38076506/effectiveness-of-an-extraoral-cold-and-vibrating-device-in-reducing-pain-perception-during-deposition-of-local-anesthesia-in-pediatric-patients-aged-3-12-years-a-split-mouth-crossover-study
#23
JOURNAL ARTICLE
Ashveeta Shetty, Shilpa S Naik, Rucha Bhise Patil, Parnaja Sanjay Valke, Sonal Mali, Diksha Patil
BACKGROUND: Local anesthetic injections may induce pain in children, leading to fear and anxiety during subsequent visits. Among the various approaches recommended to reduce pain, one is the use of a Buzzy Bee™ device that operates on the concept of gate control theory and distraction. The literature regarding its effectiveness during the deposition of local anesthesia remains limited; hence, the aim of the present study was to determine the efficacy of extraoral cold and vibrating devices in reducing pain perception during the deposition of local anesthesia...
December 2023: Journal of Dental Anesthesia and Pain Medicine
https://read.qxmd.com/read/38073986/recent-modalities-in-pain-control-and-local-anesthesia-in-dentistry-a-narrative-review
#24
REVIEW
Abhishek Pahade, Pavan Bajaj, Unnati Shirbhate, Hussain Ali John
Pain in the orofacial region or within the tooth is one of the most common complaints patients report to a dental office. An efficient practitioner must have adequate knowledge and tools to address and remedy the problem. Pain control in dentistry has a rich history and learning about it gives an insight into how the current modalities being used came into existence. As dentistry keeps evolving, newer and more efficient modalities have been developed for pain control. Dental pain is primarily remedied by dental practitioners and clinicians involved in emergency medicine; it may result due to various causes, mainly insulting the tooth or complications involved in and after oral surgery...
November 2023: Curēus
https://read.qxmd.com/read/38040604/efficacy-of-adjuvant-dexmedetomidine-on-penile-block-for-pediatric-hypospadias-repair
#25
JOURNAL ARTICLE
Amirali Khosravi, Simin Azemati, Golnar Gharaati, Mehdi Shirazi, Laleh Dehghanpisheh, Naeimehossadat Asmarian
INTRODUCTION: The management of postoperative pain, particularly in younger children, presents a challenge due to their limited ability to articulate the intensity of pain, lower pain threshold, and restricted availability of approved analgesics for pediatric use. Peripheral nerve blocks may be favored over neuraxial blocks because they allow quicker mobilization after surgery. OBJECTIVE: The present study aims to investigate the potential impact of adding dexmedetomidine to a local anesthetic (bupivacaine) on the analgesic efficacy in dorsal penile nerve block in hypospadias repair surgery...
November 20, 2023: Journal of Pediatric Urology
https://read.qxmd.com/read/38025549/recent-trends-in-anesthetic-agents-and-techniques-for-ophthalmic-anesthesia
#26
REVIEW
Prateek Upadhyay, Parul Ichhpujani, Abhilasha Solanki
Effective and safe ophthalmic anesthesia is essential for the delivery of ophthalmic perioperative care both for children and adults. Recent years have seen a major change in form of smaller incisions for most ophthalmic surgical techniques, thus making them less invasive. Additionally, most ophthalmic surgeries are now day-care surgeries at ambulatory surgical centers. The parallel advancements in the field of anesthesiology have boosted the standard of perioperative care. The purpose of this narrative review was to evaluate current trends in anesthetic agents and techniques for ophthalmic anesthesia primarily centered around deep sedation and general anesthesia as per the concerns of practicing anesthesiologists while briefly acquainting with local anesthesia advances...
2023: Journal of Anaesthesiology, Clinical Pharmacology
https://read.qxmd.com/read/38021496/comparative-evaluation-of-electronic-acupuncture-pen-and-2-lignocaine-gel-as-an-intraoral-topical-anesthetic-agent-in-children
#27
JOURNAL ARTICLE
Pranjali V Deulkar, Nilesh V Rathi, Nilima Thosar, Sphurti P Bane, Meghana A Deshpande
Background The most exasperating aspect for pediatric patients in a dental setup is the fear and anxiety caused by injections, called "blenophobia". There are numerous local anesthetic agents available to reduce the needle prick pain. Taking into consideration the paradigm shift, there is always a possibility for alternate treatment options. This study aimed to evaluate and compare the effectiveness of transcutaneous electrical nerve stimulation (TENS) application through an electronic acupuncture pen (Meridian Energy Acupuncture Pen W-912 GENERIC) and 2% lignocaine gel as an intraoral topical anesthetic agent in children...
October 2023: Curēus
https://read.qxmd.com/read/37997671/use-of-topical-phenol-in-awake-young-children-for-tympanostomy-tube-placement
#28
JOURNAL ARTICLE
Franklin L Rimell, Shelagh Cofer, Theodore Truitt, Grace Nimmons, Jay Raisen
Importance: Phenol kits cleared by the Food and Drug Administration (FDA) are indicated as a topical anesthetic for the tympanic membrane (TM) in adults. However, there is no existing literature that reports outcomes to support the safety and use of phenol on the TM of awake children. Objective: Determine if topical phenol is safe and at low risk for complications and therefore be used effectively in awake children to facilitate office otologic procedures as in adults. Design, Setting, and Participants: Children under 21 years of age whose parents agreed to participate in an awake office setting for tympanostomy tube (TT) placement...
November 24, 2023: Ear, Nose, & Throat Journal
https://read.qxmd.com/read/37997373/disposition-of-levobupivacaine-during-intraoperative-continuous-caudal-epidural-analgesia-in-a-preterm-neonate
#29
JOURNAL ARTICLE
Jan Sipek, Pavla Pokorna, Martin Sima, Jitka Styblova, Vladimir Mixa
BACKGROUND: Continuous caudal epidural analgesia used intraoperatively in children is an effective and safe technique. However, in preterm neonates, developmental factors may significantly affect levobupivacaine disposition, leading to variable pharmacokinetics, pharmacodynamics, and potential large-variable systemic toxicity of local anesthetics. OBJECTIVE: To our knowledge, this is the first case report describing the disposition of levobupivacaine used for intraoperative caudal epidural analgesia in a preterm neonate treated for the postoperative pain profile...
November 22, 2023: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/37997231/adverse-effects-of-articaine-versus-lidocaine-in-pediatric-dentistry-a-meta-analysis
#30
Ling Li, Da-Lei Sun
Over the last few years, numerous reports have lauded the efficacy of articaine hydrochloride as a local anesthetic (LA) in dental procedures. Numerous studies have shown that articaine outperforms lidocaine in various aspects of dental treatment, leading to its widespread adoption in both adults and children. Despite the publications of comparative studies, there remains a dearth of systematic reviews examining the adverse effects of articaine versus lidocaine in randomized controlled trials. The aim was to assess the available research on the adverse effects of articaine and lidocaine in pediatric dentistry...
November 2023: Journal of Clinical Pediatric Dentistry
https://read.qxmd.com/read/37990606/efficacy-of-eutectic-topical-anesthesia-in-stainless-steel-crown-procedures-for-primary-molars-a-randomized-controlled-trial
#31
JOURNAL ARTICLE
Arwa Soni, J Jasmin Winnier, Zaineb Haradwala, Sanjana Kodical, Amil Joshi, Ashveeta Shetty
BACKGROUND: Prior literature highlights the importance of local anesthesia (LA) for stainless steel crown (SSC) preparation and placement. Nevertheless, the effectiveness of a eutectic mixture of local anesthesia (EMLA), a topical anesthesia, for this purpose remains unexplored. AIM: The study evaluated the effectiveness of two EMLA application methods during SSC preparation and placement. DESIGN: Eighty-four children between 4 and 8 years of age were randomly allocated to three intervention groups...
November 21, 2023: International Journal of Paediatric Dentistry
https://read.qxmd.com/read/37971071/erector-spinae-plane-blocks-a-narrative-update
#32
REVIEW
Adrian Bosenberg
The erector spinae plane block (ESPB) is perhaps one of the most interesting of the tissue plane blocks described recently. There has been an exponential increase in the number of publications for both adults and children over the past 5 years. Single-shot, intermittent bolus, and continuous infusion techniques have been used effectively. Both the efficacy and safety of the procedure are widely accepted, but the exact mechanism by which the local anesthetic spreads from the tip of the transverse process to block the dorsal and ventral rami of the spinal nerves is controversial and needs clarification...
March 2024: Paediatric Anaesthesia
https://read.qxmd.com/read/37959290/hand-holding-s-effect-on-children-s-pain-perception-and-anxiety-during-dental-anesthetic-injections
#33
JOURNAL ARTICLE
Johnny Kharouba, Gal Berman, Shlomo Elbaharay, Neta Kaplan, Izabella Efremenko, Sigalit Blumer
Local anesthetic injections are an essential tool in dentistry, particularly in pediatric dentistry. The needle penetrating the tissue can cause stress, anxiety, and pain. Studies have shown that using touch may alleviate pain and reduce patient anxiety. Yet, this has not been tested in pediatric dental patients. Therefore, this study examined the effect of hand-holding on children undergoing local anesthetic injections. Its effect on children's pain perception was tested, with the hypothesis that pain perception would be lower for children whose hand was held by an assistant...
October 29, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37934911/-ultrasound-guided-caudal-block-with-ropivacaine-in-infraumbilical-surgeries-in-pediatric-patients
#34
RANDOMIZED CONTROLLED TRIAL
Karla Itzel Gutiérrez-Riveroll, Juan José Dosta-Herrera, Héctor Jorge Mejía-Picazo, Karla Guadalupe Lozada-Rosete, Martha Aránzazu Pérez-Penilla
BACKGROUND: The use of local anesthetics as part of multimodal analgesia is an attractive concept in pediatric patients, since the evaluation and management of pain is a challenge in children under 7 years of age. Despite having guidelines and multiple studies on volume calculation, no safe and effective recommendation has been issued. OBJECTIVE: To demonstrate that ultrasound-guided caudal block with a dose of 0.75 mL/kg of 0.2% ropivacaine has the same analgesic effect as a dose of 1...
October 2, 2023: Revista Médica del Instituto Mexicano del Seguro Social
https://read.qxmd.com/read/37871332/effectiveness-of-liposomal-bupivacaine-with-bupivacaine-hydrochloride-vs-bupivacaine-hydrochloride-alone-as-a-local-anesthetic-for-children-undergoing-ambulatory-urologic-surgery-the-baby-orioles-randomized-clinical-trial
#35
JOURNAL ARTICLE
Andrew T Gabrielson, Logan Galansky, Tamir Sholklapper, Chad Crigger, Hiten D Patel, Kelly Harris, Nora Haney, Yuezhou Jing, Ming-Hsien Wang, Charlotte Wu, John P Gearhart, Heather N Di Carlo
PURPOSE: We sought to determine if the addition of liposomal bupivacaine to bupivacaine hydrochloride improves opioid-free rate and postoperative pain scores among children undergoing ambulatory urologic surgery. MATERIALS AND METHODS: A prospective, phase 3, single-blinded, single-center randomized trial with superiority design was conducted in children 6-18 yr undergoing ambulatory urologic procedures between October 2021-April 2023. Patients were randomized (1:1) to receive dorsal penile nerve block (penile procedures) or incisional infiltration with spermatic cord block (inguinal/scrotal procedures) with weight-based liposomal bupivacaine plus bupivacaine hydrochloride or bupivacaine hydrochloride alone...
October 23, 2023: Journal of Urology
https://read.qxmd.com/read/37863700/transversus-abdominis-plane-block-vs-local-wound-infiltration-for-elective-minimally-invasive-cholecystectomy-in-children-a-prospective-randomized-trial
#36
JOURNAL ARTICLE
Sindhu Mannava, Niloufar Hafezi, Farheen Turk, Cameron Colgate, Johanna Askegard-Giesmann, Troy Markel, Nicole Horn, Brian Gray
BACKGROUND: The efficacy of transversus abdominis plane (TAP) block versus local anesthetic wound infiltration (LWI) in pediatric laparoscopic surgery is largely unknown. The objective of this study was to prospectively analyze this in minimally invasive cholecystectomy. We hypothesized that TAP block would be superior to LWI in terms of pain control and post-operative complications. METHODS: We conducted a prospective, randomized, single-blinded, controlled trial between 2017 and 2022 after obtaining Institutional Review Board (IRB) approval...
September 22, 2023: Journal of Pediatric Surgery
https://read.qxmd.com/read/37861636/evaluation-of-the-effectiveness-of-photobiomodulation-therapy-as-an-alternative-method-to-local-anesthesia-injection-in-pediatric-dentistry
#37
RANDOMIZED CONTROLLED TRIAL
Hajar Mahmoud Diab, Magda A El-Malt, Yomna Osama Mourad
BACKGROUND: The idea of receiving local anesthesia (LA) via an injection is a major source of dental fear and anxiety. In children, dental anxiety is considered the main reason for avoiding dental treatments. Moreover, there are potential complications during/after LA administration. Thus, it is necessary to search for painless, low-risk, and nonpharmacological anesthetic approaches. AIM: This study was performed to evaluate the effectiveness of photobiomodulation (PBM) therapy as an alternative method to LA injection for conventional restorative treatments in pediatric patients...
2023: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://read.qxmd.com/read/37841518/sucrose-solution-for-alleviating-needle-pain-during-inferior-alveolar-nerve-block-in-children-aged-7-10-years-a-randomized-clinical-trial
#38
JOURNAL ARTICLE
Supriya Thambireddy, Nirmala Svsg, Sivakumar Nuvvula
BACKGROUND: Intraoral local anesthesia is essential for delivering dental care; however, injection of this local anesthetic is perceived as the most painful and distressing agent for children, parents, and healthcare providers. Reducing pain as much as possible is essential to ensure smooth subsequent treatment procedures, especially in pediatric dentistry. In clinical practice, oral sucrose administration has been reported to decrease the pain during heel lance and cold pressor tests in neonates and children...
October 2023: Journal of Dental Anesthesia and Pain Medicine
https://read.qxmd.com/read/37818989/airway-topicalization-in-pediatric-anesthesia-an-international-cross-sectional-study
#39
JOURNAL ARTICLE
H A Iliff, A Baxter, A Chakladar, Y Endlich, B McGuire, J Peyton
BACKGROUND: There is no national or international consensus or guideline on recommended dosing of lidocaine for airway topicalization in children. Doses quoted in the literature vary substantially. AIMS: The primary aim of the study was to ascertain current international dosing practices (mg.kg-1 and concentration of solution) for lidocaine airway topicalization in children. The secondary aims included examining aftercare instructions for those receiving lidocaine airway topicalization and instances of local anesthetic systemic toxicity secondary to the use of lidocaine for airway topicalization in pediatric patients...
February 2024: Paediatric Anaesthesia
https://read.qxmd.com/read/37750429/don-t-we-overestimate-drug-allergies-in-children
#40
JOURNAL ARTICLE
Daniela Podlecka, Joanna Jerzyńska, Agnieszka Brzozowska
OBJECTIVES: On average about 10% of parents report hypersensitivity to at least 1 drug in their children. After diagnosis process a few of these reactions are being confirmed as drug hypersensitivity reactions. The aim of the study was to assess the real-life prevalence of drug hypersensitivity in children based on drug provocation tests. MATERIAL AND METHODS: The authors included 113 children, aged 4-18 years, referred to Pediatrics and Allergy Clinic in Łódź, Poland, due to incidence of adverse reaction during treatment...
September 25, 2023: International Journal of Occupational Medicine and Environmental Health
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