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https://www.readbyqxmd.com/read/28095368/iron-overload-and-altered-iron-metabolism-in-ovarian-cancer
#1
Stephanie Rockfield, Joseph Raffel, Radhe Mehta, Nabila Rehman, Meera Nanjundan
Iron is an essential element required for many processes within the cell. Dysregulation in iron homeostasis due to iron overload is detrimental. This nutrient is postulated to contribute to the initiation of cancer; however, the mechanisms by which this occurs remain unclear. Defining how iron promotes the development of ovarian cancers from precursor lesions is essential for developing novel therapeutic strategies. In this review, we discuss (1) how iron overload conditions may initiate ovarian cancer development, (2) dysregulated iron metabolism in cancers, (3) the interplay between bacteria, iron, and cancer, and (4) chemotherapeutic strategies targeting iron metabolism in cancer patients...
January 14, 2017: Biological Chemistry
https://www.readbyqxmd.com/read/28093197/influence-of-the-bacterial-growth-phase-on-the-magnetic-properties-of-magnetosomes-synthesized-by-magnetospirillum-gryphiswaldense
#2
L Marcano, A García-Prieto, D Muñoz, L Fernández Barquín, I Orue, J Alonso, A Muela, M L Fdez-Gubieda
BACKGROUND: The magnetosome biosynthesis is a genetically controlled process but the physical properties of the magnetosomes can be slightly tuned by modifying the bacterial growth conditions. METHODS: We designed two time-resolved experiments in which iron-starved bacteria at the mid-logarithmic phase are transferred to Fe-supplemented medium to induce the magnetosomes biogenesis along the exponential growth or at the stationary phase. We used flow cytometry to determine the cell concentration, transmission electron microscopy to image the magnetosomes, DC and AC magnetometry methods for the magnetic characterization, and X-ray absorption spectroscopy to analyze the magnetosome structure...
January 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28091535/visualization-of-the-role-of-host-heme-on-the-virulence-of-the-heme-auxotroph-streptococcus-agalactiae
#3
Laetitia Joubert, Jean-Baptiste Dagieu, Annabelle Fernandez, Aurélie Derré-Bobillot, Elise Borezée-Durant, Isabelle Fleurot, Alexandra Gruss, Delphine Lechardeur
Heme is essential for several cellular key functions but is also toxic. Whereas most bacterial pathogens utilize heme as a metabolic cofactor and iron source, the impact of host heme during bacterial infection remains elusive. The opportunist pathogen Streptococcus agalactiae does not synthesize heme but still uses it to activate a respiration metabolism. Concomitantly, heme toxicity is mainly controlled by the HrtBA efflux transporter. Here we investigate how S. agalactiae manages heme toxicity versus benefits in the living host...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28081368/smart-metal-organic-framework-coatings-triggered-anti-biofilm-compound-release
#4
Birgit Claes, Tom Boudewijns, Laurens Muchez, Geert Hooyberghs, Erik V Van der Eycken, Jozef Vanderleyden, Hans P Steenackers, Dirk E De Vos
Metal-organic frameworks (MOFs) have a large potential for delivery of active molecules. Here, a MOF coating is investigated as a smart host matrix for triggered release of anti-biofilm compounds. Besides a coating consisting of the regular Fe-terephthalate MIL-88B(Fe), a new hydrophobic MIL-88B(Fe) coating is synthesized in hydrothermal conditions using palmitic acid as a lattice terminating group. These porous materials are used as a host matrix for the anti-biofilm compound 5-(4-chlorophenyl)-N-(2-isobutyl)-2-aminoimidazole, which has a specific biofilm inhibiting effect at concentrations at which no activity against planktonic cells is detected...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28078797/in-situ-incubation-of-iron-sulfur-mineral-reveals-a-diverse-chemolithoautotrophic-community-and-a-new-biogeochemical-role-for-thiomicrospira
#5
Roman A Barco, Colleen L Hoffman, Gustavo A Ramírez, Brandy M Toner, Katrina J Edwards, Jason B Sylvan
Sulfide mineral precipitation occurs at mid-ocean ridge (MOR) spreading centers, both in the form of plume particles and seafloor massive sulfide structures. A common constituent of MOR is the iron-bearing sulfide mineral pyrrhotite, which was chosen as a substrate for in-situ incubation studies in shallow waters of Catalina Island, CA to investigate the colonization of iron-oxidizing bacteria. Microbial community datasets were obtained from in-situ incubated pyrrhotite, allowing for direct comparison to microbial communities of iron-sulfides from active and inactive chimneys in deep-sea environments...
January 12, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28077337/stress-hormone-epinephrine-adrenaline-and-norepinephrine-noradrenaline-effects-on-the-anaerobic-bacteria
#6
REVIEW
Lyudmila Boyanova
Microbial endocrinology is a relatively new research area that already encompasses the anaerobes. Stress hormones, epinephrine and norepinephrine, can affect the growth of anaerobic bacteria such as Fusobacterium nucleatum, Prevotella spp., Porhyromonas spp., Tanerella forsythia and Propionibacterium acnes and can increase virulence gene expression, iron acquisition and many virulence factors of some anaerobic species such as Clostridium perfringens, Porphyromonas gingivalis and Brachyspira pilosicoli. Epinephrine and norepinephrine effects can lead to a growth increase or decrease, or no effect on the growth of the anaerobes...
January 8, 2017: Anaerobe
https://www.readbyqxmd.com/read/28077273/reevaluating-the-mechanism-of-excitation-energy-regulation-in-iron-starved-cyanobacteria
#7
Hui-Yuan S Chen, Michelle Liberton, Himadri B Pakrasi, Dariusz M Niedzwiedzki
This paper presents spectroscopic investigations of IsiA, a chlorophyll a-binding membrane protein produced by cyanobacteria grown in iron-deficient environments. IsiA, if associated with photosystem I, supports photosystem I in light harvesting by efficiently transferring excitation energy. However, if separated from photosystem I, IsiA exhibits considerable excitation quenching observed as a substantial reduction of protein-bound chlorophyll a fluorescence lifetime. Previous spectroscopic studies suggested that carotenoids are involved in excitation energy dissipation and in addition play a second role in this antenna complex by supporting chlorophyll a in light harvesting by absorbing in the spectral range inaccessible for chlorophyll a and transferring excitation to chlorophylls...
January 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28076655/fecal-total-iron-concentration-is-inversely-associated-with-fecal-lactobacillus-in-preschool-children
#8
Sasank Kalipatnapu, Sivaraman Kuppuswamy, Giriprasad Venugopal, Venkatesh Kaliaperumal, Balamurugan Ramadass
BACKGROUND: Iron deficiency is associated with stunting and poor performance in children. Oral iron supplementation is widely promoted to correct iron deficiency. However, excess iron may be toxic to beneficial luminal gut bacteria and could support growth of pathobionts. OBJECTIVE: To analyze the fecal total iron concentration and fecal Lactobacillus levels in a cohort of stunted and normal children. DESIGN: The study was undertaken in two different locations...
January 11, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28074004/signaling-by-two-component-system-noncognate-partners-promotes-intrinsic-tolerance-to-polymyxin-b-in-uropathogenic-escherichia-coli
#9
Kirsten R Guckes, Erin J Breland, Ellisa W Zhang, Sarah C Hanks, Navleen K Gill, Holly M S Algood, Jonathan E Schmitz, Charles W Stratton, Maria Hadjifrangiskou
Bacteria use two-component systems (TCSs) to react appropriately to environmental stimuli. Typical TCSs comprise a sensor histidine kinase that acts as a receptor coupled to a partner response regulator that coordinates changes in bacterial behavior, often through its activity as a transcriptional regulator. TCS interactions are typically confined to cognate pairs of histidine kinases and response regulators. We describe two distinct TCSs in uropathogenic Escherichia coli (UPEC) that interact to mediate a response to ferric iron...
January 10, 2017: Science Signaling
https://www.readbyqxmd.com/read/28068534/potential-effects-of-loading-nano-zero-valent-iron-discharged-on-membrane-fouling-in-an-anoxic-oxic-membrane-bioreactor
#10
Lijie Zhou, Weiqin Zhuang, Xin Wang, Ke Yu, Shufang Yang, Siqing Xia
A laboratory-scale submerged anoxic-oxic membrane bioreactor for municipal wastewater was operated to investigate the potential effects of loading suspended nano zero valent iron (nZVI, 25 and 50 mg/L) discharged on the membrane fouling. nZVI transformed rapidly into Fe(n+), generated reactive oxygen species (ROS) and caused oxidative stress. This result rapidly led to the cell lysis and bacteria death, and further resulted in the decrease of biomass and extracellular polymeric substances (EPS). nZVI also thinned the membrane fouling layer...
January 3, 2017: Water Research
https://www.readbyqxmd.com/read/28067656/magnetite-nanoparticles-influence-the-ammonium-oxidizing-bacteria-activity-during-nitritation-process
#11
Simone Perazzoli, Camila Michels, Hugo M Soares
With nanotechnology dissemination, nanomaterials' (NMs) release into the environment is inevitable and may adversely affect the wastewater treatment processes. Among the NMs, the iron oxide nanoparticles have a considerable commercial potential, mainly because their magnetic properties, high catalytic ability and antimicrobial activity. However, few studies have examined their potential effect on the biological wastewater treatment. In this process, ammonium-oxidizing bacteria (AOB) are sensitive to the presence of inhibitory compounds and are useful as biosensors to assess contaminant toxicity information...
January 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28063654/biochar-decreases-nitrogen-oxide-and-enhances-methane-emissions-via-altering-microbial-community-composition-of-anaerobic-paddy-soil
#12
Ning Wang, Zhi-Zhou Chang, Xi-Mei Xue, Jian-Guang Yu, Xiao-Xia Shi, Lena Q Ma, Hong-Bo Li
Biochar application to agricultural soil is an appealing approach to mitigate nitrous oxide (N2O) and methane (CH4) emissions. However, the underlying microbial mechanisms are unclear. In this study, a paddy soil slurry was incubated anaerobically for 14d with biochar amendments produced from rice straw at 300, 500, or 700°C (B300, B500, and B700) to study their influences on greenhouse gas emissions. Illumina sequencing was used to characterize shift of soil bacterial and archaeal community composition. After peaking at day 1, N2O emission then sharply decreased to low levels while CH4 started to emit at day 3 then continually increased with incubation...
January 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28062866/-bovine-lactoferrin-decreases-the-invasion-of-salmonella-enterica-to-hep-2-cells
#13
Liz J Barreto Arce, Carmen A Contreras García, David Durand Vara, Theresa Ochoa Woodell
OBJECTIVE: To assess the effect of bovine lactoferrin (bLf) on the invasion of Salmonella enterica ser. Typhimurium to HEp-2 cells. MATERIALS AND METHODS: HEp-2 monolayers were infected with 106 colony forming unit (CFU) of bacteria in the absence and presence of 1 and 10 mg/mL of bLf (iron-saturated) and incubated 1.5 hours at 37°C. Two treatments were evaluated: pre- infection (HEp-2 cells were incubated with bLf one hour prior to infection with Salmonella) and post-infection (bLf was added 15 minutes after the infection)...
October 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28061804/the-extracellular-proteome-of-two-bifidobacterium-species-reveals-different-adaptation-strategies-to-low-iron-conditions
#14
Pamela Vazquez-Gutierrez, Marc J A Stevens, Peter Gehrig, Simon Barkow-Oesterreicher, Christophe Lacroix, Christophe Chassard
BACKGROUND: Bifidobacteria are among the first anaerobic bacteria colonizing the gut. Bifidobacteria require iron for growth and their iron-sequestration mechanisms are important for their fitness and possibly inhibit enteropathogens. Here we used combined genomic and proteomic analyses to characterize adaptations to low iron conditions of B. kashiwanohense PV20-2 and B. pseudolongum PV8-2, 2 strains isolated from the feces of iron-deficient African infants and selected for their high iron-sequestering ability...
January 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28052950/sepsis-and-siderosis-yersinia-enterocolitica-and-hereditary-haemochromatosis
#15
Phoebe A Thwaites, Marion L Woods
A 60-year-old woman was admitted with sepsis, relative bradycardia, CT evidence of numerous small liver abscesses and 'skin bronzing' consistent with hereditary haemochromatosis (HH). Yersinia enterocolitica O:9 infection was confirmed by serology specimens taken 10 days apart. Iron overload was detected, and homozygous C282Y gene mutation confirmed HH. Liver biopsy revealed grade IV siderosis with micronodular cirrhosis. Haemochromatosis is a common, inherited disorder leading to iron overload that can produce end-organ damage from excess iron deposition...
January 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28050858/thermophilic-bacteria-are-potential-sources-of-novel-rieske-non-heme-iron-oxygenases
#16
Joydeep Chakraborty, Chiho Suzuki-Minakuchi, Kazunori Okada, Hideaki Nojiri
Rieske non-heme iron oxygenases, which have a Rieske-type [2Fe-2S] cluster and a non-heme catalytic iron center, are an important family of oxidoreductases involved mainly in regio- and stereoselective transformation of a wide array of aromatic hydrocarbons. Though present in all domains of life, the most widely studied Rieske non-heme iron oxygenases are found in mesophilic bacteria. The present study explores the potential for isolating novel Rieske non-heme iron oxygenases from thermophilic sources. Browsing the entire bacterial genome database led to the identification of 45 homologs from thermophilic bacteria distributed mainly among Chloroflexi, Deinococcus-Thermus and Firmicutes...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28050844/microbial-nitrate-removal-by-waste-iron-shavings-from-the-biological-and-catalytic-ozonation-treated-dyeing-and-finishing-wastewater
#17
Jieting Ma, Yunlu Chen, Gang Luo, Jianxin Nie, Zhigang Guo, Yan Liu, Luming Ma
The concentration of total nitrogen (TN) (between 40 and 60 mg/L, mainly nitrate) in the biological and catalytic ozonation treated dyeing and finishing wastewater needs to be reduced before discharge. The present study investigated the feasibility of using waste iron shavings as electron donor for nitrogen removal by biological denitrification. Two anoxic sequencing batch reactors (AnSBR) were continuously operated for more than 100 days. The results showed that the TN removal efficiency increased from 12% in the control reactor (AnSBR-C) to 20% in the reactor with waste iron shavings (AnSBR-Fe)...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28049145/the-fumarate-reductase-of-bacteroides-thetaiotaomicron-unlike-that-of-escherichia-coli-is-configured-so-that-it-does-not-generate-reactive-oxygen-species
#18
Zheng Lu, James A Imlay
: The impact of oxidative stress upon organismal fitness is most apparent in the phenomenon of obligate anaerobiosis. The root cause may be multifaceted, but the intracellular generation of reactive oxygen species (ROS) likely plays a key role. ROS are formed when redox enzymes accidentally transfer electrons to oxygen rather than to their physiological substrates. In this study, we confirm that the predominant intestinal anaerobe Bacteroides thetaiotaomicron generates intracellular ROS at a very high rate when it is aerated...
January 3, 2017: MBio
https://www.readbyqxmd.com/read/28043205/heavy-metal-bioleaching-and-sludge-stabilization-in-a-single-stage-reactor-using-indigenous-acidophilic-heterotrophs
#19
Akanksha Mehrotra, T R Sreekrishnan
Simultaneous sludge digestion and metal leaching (SSDML) have been reported at mesophilic temperature. It is generally perceived that while sludge stabilization is effected by heterotrophs at neutral pH, metal bioleaching is done by acidophilic autotrophs. However, little information is available on the microbial communities involved in the process. This study carried out SSDML in a single stage reactor using sludge indigenous microorganisms and looked at the bacterial communities responsible for the process...
January 3, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28042698/geochemically-distinct-carbon-isotope-distributions-in-allochromatium-vinosum-dsm-180-t-grown-photoautotrophically-and-photoheterotrophically
#20
T Tang, W Mohr, S R Sattin, D R Rogers, P R Girguis, A Pearson
Anoxygenic, photosynthetic bacteria are common at redox boundaries. They are of interest in microbial ecology and geosciences through their role in linking the carbon, sulfur, and iron cycles, yet much remains unknown about how their flexible carbon metabolism-permitting either autotrophic or heterotrophic growth-is recorded in the bulk sedimentary and lipid biomarker records. Here, we investigated patterns of carbon isotope fractionation in a model photosynthetic sulfur-oxidizing bacterium, Allochromatium vinosum DSM180(T) ...
January 1, 2017: Geobiology
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