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https://www.readbyqxmd.com/read/28318006/inhibiting-the-bfrb-bfd-interaction-in-pseudomonas-aeruginosa-causes-irreversible-iron-accumulation-in-bacterioferritin-and-iron-deficiency-in-the-bacterial-cytosol
#1
Kate Eshelman, Huili Yao, Achala N D Punchi Hewage, Jacqueline J Deay, Josephine R Chandler, Mario Rivera
Iron is an essential nutrient for bacteria but the reactivity of Fe(2+) and the insolubility of Fe(3+) present significant challenges to bacterial cells. Iron storage proteins contribute to ameliorating these challenges by oxidizing Fe(2+) using O2 and H2O2 as electron acceptors, and by compartmentalizing Fe(3+). Two types of iron-storage proteins coexist in bacteria, the ferritins (Ftn) and the heme-containing bacterioferritins (Bfr), but the reasons for their coexistence are largely unknown. P. aeruginosa cells harbor two iron storage proteins (FtnA and BfrB), but nothing is known about their relative contributions to iron homeostasis...
March 20, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28317737/identification-of-the-key-excreted-molecule-by-lactobacillus-fermentum-related-to-host-iron-absorption
#2
Ana González, Natividad Gálvez, Jesús Martín, Fernando Reyes, Ignacio Pérez-Victoria, Jose M Dominguez-Vera
We have taken a vital step towards understanding why probiotic bacteria increase iron absorption in the gastrointestinal tract. We show here that Lactobacillus fermentum, one of the main probiotics of the microbiota, exhibits an extraordinary ferric-reducing activity. This activity is predominantly due to an excreted molecule: p-hydroxyphenyllactic acid (HPLA). Reduction of Fe(III) to Fe(II) is essential for iron absorption in the gastrointestinal tract. By reducing Fe(III), HPLA boosts Fe(II) absorption through the DMT1 channels of enterocytes...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28303956/inhibitory-role-of-acyl-homoserine-lactones-in-hemolytic-activity-and-viability-of-streptococcus-pyogenes-m6-s165
#3
Sunil D Saroj, Linda Holmer, Júlia M Berengueras, Ann-Beth Jonsson
Streptococcus pyogenes an adapted human pathogen asymptomatically colonizes the nasopharynx, among other polymicrobial communities. However, information on the events leading to the colonization and expression of virulence markers subject to interspecies and host-bacteria interactions are limited. The interference of acyl homoserine lactones (AHLs) with the hemolytic activity and viability of S. pyogenes M6 S165 was examined. AHLs, with fatty acid side chains ≥12 carbon atoms, inhibited hemolytic activity by downregulating the expression of the sag operon involved in the production of streptolysin S...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28300176/nanoscale-zero-valent-iron-persulfate-enhanced-upflow-anaerobic-sludge-blanket-reactor-for-dye-removal-insight-into-microbial-metabolism-and-microbial-community
#4
Fei Pan, Xiaohan Zhong, Dongsheng Xia, Xianze Yin, Fan Li, Dongye Zhao, Haodong Ji, Wen Liu
This study investigated the efficiency of nanoscale zero-valent iron combined with persulfate (NZVI/PS) for enhanced degradation of brilliant red X-3B in an upflow anaerobic sludge blanket (UASB) reactor, and examined the effects of NZVI/PS on anaerobic microbial communities during the treatment process. The addition of NZVI (0.5 g/L) greatly enhanced the decolourization rate of X-3B from 63.8% to 98.4%. The Biolog EcoPlate(TM) technique was utilized to examine microbial metabolism in the reactor, and the Illumina MiSeq high-throughput sequencing revealed 22 phyla and 88 genera of the bacteria...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28296339/controlling-the-hydrolysis-and-loss-of-nitrogen-fertilizer-urea-using-a-nanocomposite
#5
Naiqin Zhong, Linglin Zhou, Pan Zhao, Yu Chi, Dongfang Wang, Pan Wang, Ning Liu, Dongqing Cai, Zhengyan Wu
Urea tends to be hydrolyzed by urease and then migrate to the environment, resulting in low utilization efficiency and severe environmental contamination. To solve this problem, a fertilizer synergist (FS) was developed using sodium humate transported by a nanonetwork through hydrogen bonds. FS could effectively inhibit the hydrolysis, reduce the loss amount, and enhance the UE of nitrogen. Furthermore, FS exerted significant positive effects on the expression of several nitrogen uptake-related genes, ion flux in maize roots, the growth of crops and the organic matter in soil...
March 10, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28294074/probiotics-as-a-tool-to-biosynthesize-metallic-nanoparticles-research-reports-and-patents-survey
#6
Nida Ahktar, Kamla Pathak
BACKGROUND: Probiotics are the live microbes that exert beneficial effects on the health of the host cell and thus creating novel nanoformulations via probiotic bacteria have gained tremendous momentum recently. The probiotic bacteria are being employed in synthesizing or more specifically biosynthesizing several nanoparticles like metallic as well as non-metallic nanoparticles. Biosynthesis of metallic nanoparticles is currently focused of research nowadays due to several applications thereof...
March 13, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28293833/efficient-synthesis-and-biological-evaluation-of-new-benzopyran-annulated-pyrano-2-3-c-pyrazole-derivatives
#7
Balvantsingh M Labana, Gaurangkumar C Brahmbhatt, Tushar R Sutariya, Narsidas J Parmar, José M Padrón, Rajni Kant, Vivek K Gupta
A one-pot method has been described to synthesize benzopyran-annulated pyrano[2,3-c]pyrazoles, effectively by combining O-alkenyloxy/alkynyloxy-acetophenones with various pyrazolones in triethylammonium acetate (TEAA) under microwave irradiation. While combination of O-allyloxy- or O-prenyloxy-acetophenones with pyrazolones occurred efficiently, that of O-propargyloxy-acetophenones was found effective in the presence of ZnO catalyst, via a domino Knoevenagel-hetero-Diels-Alder (DKHDA) reaction. Aminobenzopyran frameworks were also synthesized, after nitro-containing products were reduced in tandem with iron(II) in an acidic medium...
March 14, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28289847/bacterial-diversity-in-fumarole-environments-of-the-paricut%C3%A3-n-volcano-michoac%C3%A3-n-mexico
#8
Miguel Medrano-Santillana, Elcia Margaret Souza-Brito, Robert Duran, Felix Gutierrez-Corona, Georgina Elena Reyna-López
Active volcanoes are among the most extreme environments on Earth. The extreme temperatures, presence of toxic heavy metals and low nutrient bioavailability favor the development of extremophiles. We characterized the physical-chemical parameters of and bacterial communities (T-RFLP and 16S rRNA gene libraries) inhabiting fumarole niches of the Paricutín volcano located in Michoacán (Mexico). This volcano, which surged in 1943, is one of the youngest volcanoes on Earth and the microbial diversity in this area is yet to be characterized...
March 13, 2017: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/28287735/targeted-antibiotic-delivery-selective-siderophore-conjugation-with-daptomycin-confers-potent-activity-against-multi-drug-resistant-acinetobacter-baumannii-both-in-vitro-and-in-vivo
#9
Manuka Ghosh, Patricia A Miller, Ute Möllmann, William D Claypool, Valerie A Schroeder, William R Wolter, Mark Suckow, Honglin Yu, Shuang Li, Weiqiang Huang, Jaroslav Zajicek, Marvin J Miller
In order to address the dire need for new antibiotics to treat specific strains of drug resistant Gram-negative bacterial infections, a mixed ligand analog of the natural Acinetobacter baumannii selective siderophore, fimsbactin, was coupled to daptomycin, a Gram-positive only antibiotic. The resulting conjugate, 11, has potent activity against multi-drug resistant strains of A. baumannii, both in vitro and in vivo. The study also indicates that conjugation of siderophores to "drugs" that are much larger than the siderophore (iron transport agent) itself facilitates active uptake that circumvents the normal permeability problems in Gram-negative bacteria...
March 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28287455/biosynthesis-of-sulfur-containing-trna-modifications-a-comparison-of-bacterial-archaeal-and-eukaryotic-pathways
#10
REVIEW
Mirela Čavužić, Yuchen Liu
Post-translational tRNA modifications have very broad diversity and are present in all domains of life. They are important for proper tRNA functions. In this review, we emphasize the recent advances on the biosynthesis of sulfur-containing tRNA nucleosides including the 2-thiouridine (s²U) derivatives, 4-thiouridine (s⁴U), 2-thiocytidine (s²C), and 2-methylthioadenosine (ms²A). Their biosynthetic pathways have two major types depending on the requirement of iron-sulfur (Fe-S) clusters. In all cases, the first step in bacteria and eukaryotes is to activate the sulfur atom of free l-cysteine by cysteine desulfurases, generating a persulfide (R-S-SH) group...
March 11, 2017: Biomolecules
https://www.readbyqxmd.com/read/28286877/il-22-controls-iron-dependent-nutritional-immunity-against-systemic-bacterial-infections
#11
Kei Sakamoto, Yun-Gi Kim, Hideki Hara, Nobuhiko Kamada, Gustavo Caballero-Flores, Emanuela Tolosano, Miguel P Soares, José L Puente, Naohiro Inohara, Gabriel Núñez
Host immunity limits iron availability to pathogenic bacteria, but whether immunity limits pathogenic bacteria from accessing host heme, the major source of iron in the body, remains unclear. Using Citrobacter rodentium, a mouse enteric pathogen and Escherichia coli, a major cause of sepsis in humans as models, we find that interleukin-22, a cytokine best known for its ability to promote epithelial barrier function, also suppresses the systemic growth of bacteria by limiting iron availability to the pathogen...
February 2017: Science Immunology
https://www.readbyqxmd.com/read/28284604/identification-of-the-ferric-iron-utilization-gene-b739_1208-and-its-role-in-the-virulence-of-r-anatipestifer-ch-1
#12
MengYi Wang, PengYun Zhang, DeKang Zhu, MingShu Wang, RenYong Jia, Shun Chen, KunFeng Sun, Qiao Yang, Ying Wu, XiaoYue Chen, Francis Biville, AnChun Cheng, MaFeng Liu
Riemerella anatipestifer is an important bacterial pathogen in ducks and causes heavy economic losses in the duck industry. However, the pathogensis of this bacterium is poorly understood. In this study, a putative outer membrane hemin receptor gene B739_1208 in R. anatipestifer CH-1 was deleted to determine the relationship between iron uptake and virulence. The R. anatipestifer CH-1ΔB739_1208 mutants grew significantly more slowly than the wild-type bacteria in TSB liquid medium. Further characterization revealed that the R...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28283524/pirated-siderophores-promote-sporulation-in-bacillus-subtilis
#13
Gabrielle M Grandchamp, Lews Caro, Elizabeth A Shank
In microbial communities bacteria chemically and physically interact with one another. Some of these interactions are mediated by secreted specialized metabolites that act as either intra- or inter-species signals to alter gene expression and change cell physiology. Bacillus subtilis is a well-characterized soil microbe that can differentiate into multiple cell types including metabolically dormant endospores. We were interested in identifying microbial interactions that affected sporulation in B. subtilis...
March 10, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28283522/use-of-bacteria-to-stabilize-archaeological-iron
#14
Lucrezia Comensoli, Julien Maillard, Monica Albini, Frederic Sandoz, Pilar Junier, Edith Joseph
Iron artifacts are common among the findings of archaeological excavations. The corrosion layer formed on these objected requires stabilization after their recovery, without which the destruction of the item due to physicochemical damage is likely. Current technologies for the stabilization of the corrosion layer are lengthy and generate hazardous waste products. There is therefore a pressing need for an alternative method to stabilize the corrosion layer on iron objects. The aim of this study was to evaluate an alternative conservation-restoration method using bacteria...
March 10, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28278106/interactive-effect-of-trivalent-iron-on-activated-sludge-digestion-and-biofilm-structure-in-attached-growth-reactor-of-waste-tyre-rubber
#15
Iqra Sharafat, Dania Khalid Saeed, Sumera Yasmin, Asma Imran, Zargona Zafar, Abdul Hameed, Naeem Ali
Waste tyre rubber (WTR) has been introduced as an alternative, novel media for biofilm development in several experimental systems including attached growth bioreactors. In this context, four laboratory scale static batch bioreactors containing WTR as a support material for biofilm development were run under anoxic condition for 90 days using waste activated sludge as an inoculum under the influence of different concentrations (2.5, 6.5, 8.5 mg/l) of trivalent ferric iron (Fe(3+)). The data revealed that activated sludge W with a Fe(3+) concentration of 8...
February 16, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28273650/bioanalysis-of-pseudomonas-aeruginosa-alkyl-quinolone-signalling-molecules-in-infected-mouse-tissue-using-lc-ms-ms-and-its-application-to-a-pharmacodynamic-evaluation-of-mvfr-inhibition
#16
Paul Turnpenny, Anthony Padfield, Patrick Barton, Joanne Teague, Laurence G Rahme, Michael J Pucci, Robert Zahler, Aileen Rubio
Alkyl quinolone molecules 2-heptyl-4-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)-quinolone (PQS) are important quorum sensing signals, which play a mediatory role in the pathogenesis of acute and chronic Pseudomonas aeruginosa infection. A targeted approach inhibiting the bacterial 'multiple virulence factor regulon' (MvfR) protein complex, offers the possibility to block the synthesis of MvfR-dependant signal molecules. Here, a high throughput bioanalytical method was developed using LC-MS/MS detection for the selective determination of HHQ and PQS in mouse tissue homogenate, over a sensitive range of 1-5000 and 10-5000pg/mL, respectively...
February 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28266718/a-preliminary-study-on-the-relationship-between-iron-and-black-extrinsic-tooth-stain-in-children
#17
Fangfei Zhang, Yue Li, Zhe Xun, Qian Zhang, He Liu, Feng Chen
Black extrinsic tooth stain, which has long troubled many people, is common among children and influences the esthetics of teeth. The pigment was proposed to be a black insoluble ferric compound, but this is controversial. To determine whether iron exists in black stain, we collected ten samples of black stain and ten samples of plaque separately from children with and without black stain using sterile titanium implant curettes, and analyzed the samples by inductively coupled plasma-mass spectrometry. Iron was present in both black stain and plaque, with concentrations ranging from 76...
March 7, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28266642/abundant-iron-and-sulfur-oxidizers-in-the-stratified-sediment-of-a-eutrophic-freshwater-reservoir-with-annual-cyanobacterial-blooms
#18
Long Jin, Chang Soo Lee, Chi-Yong Ahn, Hyung-Gwan Lee, Sanghyup Lee, Hyeon Ho Shin, Dhongil Lim, Hee-Mock Oh
The microbial community in eutrophic freshwater sediment was investigated from a 67-cm-deep sediment core collected from the Daechung Reservoir in South Korea, where cyanobacterial blooms have occurred annually for the past 30 years. The majority of core sediments were characterized by dark-grayish, fine-grained mud with abundant gas-escaped and thinly laminated layers. Intervals of summer and winter seasons were represented by periodic peaks of geochemical profiles of parameters such as grain size and relative carbon mass ratios to various nutrients such as nitrogen, sulfur, and phosphorus...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28264906/inactivation-of-nmb0419-encoding-a-sel1-like-repeat-slr-protein-in-neisseria-meningitidis-is-associated-with-differential-expression-of-genes-belonging-to-the-fur-regulon-and-reduced-intra-epithelial-replication
#19
Ming-Shi Li, Paul R Langford, J Simon Kroll
Neisseria meningitidis is a commensal microbe that colonizes the human nasopharynx but occasionally invades the bloodstream to cause life-threatening infection. N. meningitidis MC58 NMB0419 encodes a Sel1-like repeat (SLR)-containing protein, previously implicated in invasion of epithelial cells. A gene-regulatory function was revealed in Escherichia coli expressing plasmid-borne NMB0419 showing significantly increased epithelial adherence compared to wild type, due to increased expression of mannose-sensitive type 1 pili...
March 6, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28261669/environmental-viral-genomes-shed-new-light-on-virus-host-interactions-in-the-ocean
#20
Yosuke Nishimura, Hiroyasu Watai, Takashi Honda, Tomoko Mihara, Kimiho Omae, Simon Roux, Romain Blanc-Mathieu, Keigo Yamamoto, Pascal Hingamp, Yoshihiko Sako, Matthew B Sullivan, Susumu Goto, Hiroyuki Ogata, Takashi Yoshida
Metagenomics has revealed the existence of numerous uncharacterized viral lineages, which are referred to as viral "dark matter." However, our knowledge regarding viral genomes is biased toward culturable viruses. In this study, we analyzed 1,600 (1,352 nonredundant) complete double-stranded DNA viral genomes (10 to 211 kb) assembled from 52 marine viromes. Together with 244 previously reported uncultured viral genomes, a genome-wide comparison delineated 617 genus-level operational taxonomic units (OTUs) for these environmental viral genomes (EVGs)...
March 2017: MSphere
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