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Total electric energy delivered brain

P Rebelo, A L Green, T Z Aziz, A Kent, D Schafer, L Venkatesan, B Cheeran
BACKGROUND: Directional Deep Brain Stimulation (D-DBS) allows axially asymmetric electrical field shaping, away from structures causing side-effects. However, concerns regarding the impact on device lifespan and complexity of the monopolar survey have contributed to sparing use of these features. OBJECTIVE: To investigate whether chronically implanted D-DBS systems can improve the therapeutic window, without a negative impact on device lifespan, in thalamic deep brain stimulation (DBS)...
May 2018: Brain Stimulation
Ann-Kristin Helmers, Isabel Lübbing, Günther Deuschl, Karsten Witt, Michael Synowitz, Hubertus Maximilian Mehdorn, Daniela Falk
OBJECTIVE: Nonrechargeable deep brain stimulation (DBS) generators must be replaced when the battery capacity is exhausted. Battery life depends on many factors and differs between generator models. A new nonrechargeable generator model replaced the previous model in 2008. Our clinical impression is that the earlier model had a longer battery life than the new one. We conducted this study to substantiate this. METHODS: We determined the battery life of every DBS generator that had been implanted between 2005 and 2012 in our department for the treatment of Parkinson's disease, and compared the battery lives of the both devices...
November 3, 2017: Neuromodulation: Journal of the International Neuromodulation Society
Tao Xie, Mahesh Padmanaban, Lisa Bloom, Ellen MacCracken, Breanna Bertacchi, Abraham Dachman, Peter Warnke
Some studies have shown that low frequency stimulation (LFS, most commonly 60 Hz), compared to high frequency stimulation (HFS, most commonly 130 Hz), has beneficial effects, short-term or even long-term, on improving freezing of gait (FOG) and other axial symptoms, including speech and swallowing function, in Parkinson disease (PD) patients with bilateral subthalamic nucleus deep brain stimulation (STN DBS). However, other studies failed to confirm this. It seems not clear what determines the difference in response to LFS...
2017: Translational Neurodegeneration
Christoph van Riesen, Georg Tsironis, Doreen Gruber, Fabian Klostermann, Patricia Krause, Gerd Helge Schneider, Andreas Kupsch
Deep brain stimulation (DBS) represents an established and internationally approved therapy for movement disorders. In the present retrospective analysis, we evaluated disease-specific longevity of dual channel impulse generators (IPG) used in different movement disorders. We correlated the battery lifetime with electrical stimulation settings, "total electrical energy delivered" (TEED), stimulation modi (monopolar, double monopolar and bipolar) and targets. Specifically, we reviewed the longevity and stimulation settings of 464 IPGs implanted between 1996 until 2011 in a single university center...
June 2016: Journal of Neural Transmission
Song Luan, Timothy G Constandinou
Electrical neural stimulation is the technique used to modulate neural activity by inducing an instantaneous charge imbalance. This is typically achieved by injecting a constant current and controlling the stimulation time. However, constant voltage stimulation is found to be more energy-efficient although it is challenging to control the amount of charge delivered. This paper presents a novel, fully integrated circuit for facilitating charge-metering in constant voltage stimulation. It utilises two complementary stimulation paths...
March 15, 2014: Journal of Neuroscience Methods
Anwen M Harries, Shannon Major, Mandeep Sandhu, Christopher R Honey
INTRODUCTION: With the advent of rechargeable internal neural stimulators (rINS) for deep brain stimulation, our aim was to survey patient satisfaction and clinical efficacy in an early cohort of patients receiving this new technology. METHODS: This is an observational study on nine patients with rINS. All patients had initially received non-rechargeable INS with established efficacy of their deep brain stimulation system for either dystonia or pain. Patient satisfaction and efficacy with their rINS were established by completion of a questionnaire, a quality of life assessment (SF-36), and calculation of the total electrical energy delivered (TEED) by the rINS...
May 2012: Neuromodulation: Journal of the International Neuromodulation Society
C Blahak, H-H Capelle, H Baezner, T M Kinfe, M G Hennerici, J K Krauss
BACKGROUND AND PURPOSE: The aim of the study was to analyse the lifetime of Soletra implantable pulse generators (IPG) in deep brain stimulation (DBS) of the globus pallidus internus (GPi) for dystonia, depending on stimulation parameters and the total electrical energy delivered (TEED) by the IPG. METHODS: In a prospective series of 20 patients with GPi DBS for dystonia, we recorded IPG longevity and stimulation parameters over time. An evaluation of the TEED was performed using the previously suggested equation [(voltage(2) × pulse width × frequency)/impedance] × 1 s...
June 2011: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Ioannis U Isaias, Ron L Alterman, Michele Tagliati
BACKGROUND: Pallidal deep brain stimulation (DBS) is the best therapeutic option for patients with disabling primary generalized dystonia (PGD) that is refractory to medications. However, little is known about its long-term effects. OBJECTIVE: To describe long-term clinical outcomes in patients with PGD who underwent pallidal DBS. DESIGN: Case series. SETTING: University hospital. PATIENTS: Thirty consecutive patients with at least 2 years' follow-up after pallidal DBS for intractable PGD...
April 2009: Archives of Neurology
Luigi M Romito, Maria Fiorella Contarino, Nicola Vanacore, Anna Rita Bentivoglio, Massimo Scerrati, Alberto Albanese
Stimulation of the subthalamic nucleus (STN) is an effective treatment for advanced Parkinson's disease (PD), but the medication requirements after implant are poorly known. We performed a long-term prospective evaluation of 20 patients maintained at stable dopaminergic therapy for 5 years after bilateral STN implants, who were evaluated 6 months, 1 year, 3 years, and 5 years after surgery. We measured, during the entire observation period, the effect of deep brain stimulation on motor and functional outcome measures, the levodopa equivalent daily dose and the total electrical energy delivered...
March 15, 2009: Movement Disorders: Official Journal of the Movement Disorder Society
Alfonso Fasano, Paolo Mazzone, Carla Piano, Davide Quaranta, Francesco Soleti, Anna Rita Bentivoglio
Huntington's disease (HD) produces debilitating motor abnormalities that are poorly responsive to medical therapy. Deep brain stimulation (DBS) of the posteroventral globus pallidus internus (GPi) may offer a treatment option for patients with diskinetic phenotype and minimal cognitive impairment, but its role in the management of HD remains unclear and to date only two cases have been reported. We report the outcome of GPi-DBS in a 72-year-old man with HD. Stimulation at 130 Hz caused a rapid amelioration of chorea producing the worsening of bradykinesia, whereas 40 Hz stimulation (maintaining constant the total electrical energy delivered) improved chorea while preserving the ability to walk...
July 15, 2008: Movement Disorders: Official Journal of the Movement Disorder Society
Mathieu Anheim, Valérie Fraix, Stéphan Chabardès, Paul Krack, Alim-Louis Benabid, Pierre Pollak
The efficacy of bilateral subthalamic nucleus (STN) stimulation in Parkinson's disease (PD) is well-established but little is known about the lifetime of implanted pulse generators (IPG). To investigate the lifetime of the bilaterally implanted Itrel II(R) (Medtronic, Minneapolis) pulse generator, the first 49 consecutive patients with PD having been operated on at our center for bilateral STN chronic stimulation were reviewed with noting of the stimulation parameters in use prior to IPG replacement. The mean electrical voltage was 3...
December 2007: Movement Disorders: Official Journal of the Movement Disorder Society
R Esteller, J Echauz, T Tcheng
This study aims to determine whether there are any statistically significant effects in the intracranial EEG signal due to brain electrical stimulation that can be quantified by comparing the line length value computed in windows positioned before and after stimulated abnormal events versus windows before and after non-stimulated abnormal events. The line length feature has been previously demonstrated to preserve waveform dimensionality changes as the ones estimated by Katz's fractal dimension and is a measure sensitive to variations in signal amplitude and frequency, equivalent in some ways to Teager's energy...
2004: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Mohammed Bin-Mahfoodh, Clement Hamani, Elspeth Sime, Andres M Lozano
The longevity of batteries in internal pulse generators (IPGs) used clinically for deep brain stimulation is not known. We conducted a study to assess the life span of these batteries. From 1993 to 2000, 163 single-channel batteries were surgically implanted in our institution. The electrical settings utilized in patients who had battery failures were assessed and the total electrical energy delivered (TEED) was calculated and correlated with battery longevity. Fourteen IPGs had battery failure requiring replacement...
2003: Stereotactic and Functional Neurosurgery
E Moro, R J A Esselink, J Xie, M Hommel, A L Benabid, P Pollak
BACKGROUND: The main advantage of deep brain stimulation (DBS) in the treatment of PD is that the electrical settings can be adjusted to optimize benefits and minimize adverse effects. The main objective of this study was to discover how varying these electrical parameters impacted on parkinsonian motor signs. METHODS: Twelve patients with PD with chronic bilateral subthalamic nucleus (STN) stimulation were selected. The authors evaluated the effects of a variation in the voltages, frequencies, and pulse widths on tremor, bradykinesia, and rigidity using two different paradigms: one in which the total electrical energy delivered was held constant, and one in which this was varied...
September 10, 2002: Neurology
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