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https://www.readbyqxmd.com/read/29455251/establishing-and-characterizing-lacrispheres-from-human-lacrimal-gland-for-potential-clinical-application
#1
Shubha Tiwari, Rohini M Nair, Praseeda Vamadevan, Mohammad Javed Ali, Milind N Naik, Santosh G Honavar, Geeta K Vemuganti
PURPOSE: Lacrimal gland (LG) dysfunction leading to dry eye syndrome (DES) is an important cause of ocular morbidity. One of the potential and promising long-term management therapies for restoration of LG function could be transplantation of autologous ex vivo expanded stem cells. The present study was aimed at exploring the 2D and 3D cultures of human LG, identifying inherent stem cells and evaluating their secretory potential. METHODS: Fresh human lacrimal gland (HuLG) (n = 5) from patients undergoing therapeutic exenteration was harvested after ethical approval and informed consent...
February 17, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29452599/feasibility-and-acceptability-of-pre-operative-physical-activity-to-improve-patient-outcomes-after-major-cancer-surgery-study-protocol-for-a-pilot-randomised-controlled-trial-pepa-trial
#2
Daniel Steffens, Jane Young, Paula R Beckenkamp, James Ratcliffe, Freya Rubie, Nabila Ansari, Neil Pillinger, Michael Solomon
BACKGROUND: There is a need for evidence of the effectiveness of pre-operative exercise for patients undergoing major cancer surgery; however, recruitment to such trials can be challenging. The PrE-operative Physical Activity (PEPA) Trial will establish the feasibility and acceptability of a pre-operative exercise programme aimed to improve patient outcomes after cytoreductive surgery and pelvic exenteration. The secondary aim is to obtain pilot data on the likely difference in key outcomes (post-operative complications, length of hospital stay, post-operative functional capacity and quality of life) to inform the sample size calculation for the substantive randomised clinical trial...
February 17, 2018: Trials
https://www.readbyqxmd.com/read/29423837/analysis-of-hedgehog-signaling-in-periocular-sebaceous-carcinoma
#3
John C Bladen, Mariya Moosajee, Dhani Tracey-White, Michèle Beaconsfield, Edel A O'Toole, Michael P Philpott
PURPOSE: Sebaceous carcinoma (SC) is a clinical masquerader of benign conditions resulting in significant eye morbidity, sometimes leading to extensive surgical treatment including exenteration, and even mortality. Little is known about the genetic or molecular basis of SC. This study identifies the involvement of Hedgehog (Hh) signaling in periocular SC. METHODS: Fifteen patients with periocular SC patients were compared to 15 patients with eyelid nodular basal cell carcinoma (nBCC; a known Hh tumor), alongside four normal individuals as a control for physiological Hh expression...
February 8, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29420427/the-price-we-pay-for-radical-curative-pelvic-exenterations-prevalence-and-management-of-pain
#4
Jessica Shao-Yeung Lim, Cherry E Koh, Hannah Liu, Michael J Solomon, Charlotte S H Johnstone
BACKGROUND: Pelvic exenterations are extensive surgical procedures for locally advanced or recurrent malignancies of the pelvis. However, this is often at the cost of significant morbidity due to perioperative pain, which has been poorly studied. OBJECTIVE: This study aims to review perioperative pain management in patients undergoing pelvic exenteration. DESIGN: This is a retrospective review of patients undergoing pelvic exenteration between January 2013 and December 2014...
March 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29420418/pain-management-in-patients-undergoing-radical-pelvic-exenteration-surgery-opioid-stewardship-and-the-development-of-evidence-based-alternatives
#5
Sandra L Kopp, William L Lanier
No abstract text is available yet for this article.
March 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29403596/primary-atypical-lipomatous-tumor-of-the-orbit-a-case-report
#6
Douglas P Dworak, Shyam A Patel, Rohini Chennuri, Daniel Falco
Purpose: To describe a case of primary atypical orbital lipomatous tumor (ALT). Case Report: A 35-year-old man presented with a two-month history of left eye proptosis and vertical diplopia. His visual acuity was 20/30 OD and 20/60 OS. External examination showed proptosis and downward displacement of the left eye with mild lid erythema. Extraocular movements were reduced in the left eye, with 10% and 70% motility in upgaze and abduction/adduction, respectively...
January 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29394768/-a-case-report-of-post-radiochemotherapy-perineum-abscess-concurrent-with-recurrence-of-vaginal-cancer-for-which-total-pelvic-exenteration-was-performed
#7
Hiroki Imamura, Kohei Murata, Yoshinori Kagawa, Rieko Okubo, Takuya Sakamoto, Atsushi Naito, Kohei Murakami, Yoshiteru Katsura, Yoshiaki Ohmura, Atsushi Takeno, Shinichi Nakatsuka, Kimihiko Ito, Yutaka Takeda, Takeshi Kato, Shigeyuki Tamura
We report a case of a woman who was suffering from post-radiochemotherapy perineum abscess concurrent with the recurrence of vaginal cancer for which total pelvic exenteration was performed. A 66-year-oldwoman presentedat our hospital with irregular genital bleeding in November 2014. A series of examinations showedthat she was suffering from vaginal cancer(cT2N0M0, cStage II ). A radiochemotherapy regimen(external irradiation 45 Gy/25 Fr, CDDP 40mg/m2, 5 course)was commencedin January 2015. In the meantime, MRI revealedsome therapeutic effect, but in October 2015, MRI indicated the enlargement of the primary tumor(PD)...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394675/-a-case-of-locally-advanced-rectal-cancer-with-abscess-and-rectovesical-fistula-curatively-resected-following-preoperative-chemotherapy
#8
Tatsuya Matsumoto, Masayoshi Nakanishi, Mahito Miyamae, Koji Takao, Tomohiko Fukunaga, Eigo Otsuji
A 63-year-old man with bloody stools, anal incompetence, and feeling of fatigue was diagnosed as having a RAS mutanttype rectal cancer with abscess and rectovesical fistula. Computed tomography revealed that the tumor had invaded the seminal vesicle, prostate, and bladder and formed an abscess. In addition, his general condition was poor. Thus, we evaluated the lesion as unresectable. His nutritional status improved, and the infection was controlled after colostomy. Then, we performed chemotherapy with 5-fluorouracil, Leucovorin, and oxaliplatin(FOLFOX)plus bevacizumab...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394612/-utility-of-preoperative-chemotherapy-for-locally-advanced-colorectal-cancer
#9
Nobuhiro Takiguchi, Hiroaki Soda, Toru Tonooka, Atsushi Ikeda, Yoshihiro Nabeya, Isamu Hoshino, Ryotaro Teranaka, Tadamichi Denda
Preoperative chemotherapy has been performed for locally advanced colorectal cancer, to achieve cytoreduction, local control, and prevention of distant metastasis. The regimens of mFOLFOX6/XELOX plus bevacizumab for 3 months have been adopted to succeed curative resection for borderline resectable colorectal cancer. We examined treatment results for locally advanced colorectal cancer without distant metastasis. Thirty-four patients were examined and the mean age was 62.7 years old. The cohort comprised of 23 cases of rectal cancer and 11 of sigmoid colon cancer...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394463/primary-orbital-melanoma-treated-with-orbital-exenteration-and-postoperative-radiotherapy-a-case-report-and-review-of-the-literature
#10
Christopher P Haskins, Sommer Nurkic, Kristianna M Fredenburg, Peter T Dziegielewski, William M Mendenhall
BACKGROUND: We report on a patient with human immunodeficiency virus (HIV)-positive disease with a primary orbital melanoma treated with surgery and adjuvant radiation. METHODS: A 53-year-old woman with HIV-positive disease presented with left-sided progressive ipsilateral vision loss and proptosis. An MRI scan revealed a mass-enhancing lesion measuring 2.1 × 2.6 × 2.5 cm abutting the optic nerve. The patient underwent left orbital exenteration with temporalis flap reconstruction, pathology revealing malignant melanoma, stage T1N0M0...
February 2, 2018: Head & Neck
https://www.readbyqxmd.com/read/29388848/primary-orbital-melanoma-a-case-series-and-literature-review
#11
Edwin Figueira, Saul Rajak, Penny McKelvie, George Kalantzsis, Azzam Ismail, Michael Gonzales, Craig James, Alan McNab, Selva Dinesh
Primary orbital melanoma (POM) is a very rare condition. We report further four cases and review all previously reported cases. We present a multicentre retrospective review of patients with POM. Clinical, radiological, surgical, histological, and follow-up data is presented. Four patients with POM were identified between 2000 and 2013. All presented with proptosis and diplopia without reduced vision. Two had known pre-existing blue cell naevi. All were stage T1N0M0. All underwent exenteration with adjuvant radiotherapy...
February 1, 2018: Orbit
https://www.readbyqxmd.com/read/29387558/anterior-perineal-hernia-after-anterior-exenteration
#12
Ka Wing Wong, Terence Chun-Ting Lai, Ada Tsui-Lin Ng, Brian Sze-Ho Ho, James Hok-Leung Tsu, Chiu Fung Tsang, W K Ma, Ming Kwong Yiu
Perineal hernia is a rare complication of anterior exenteration. We reported this complication after an anterior exenteration for bladder cancer with bleeding complication requiring packing and second-look laparotomy. Perineal approach is a simple and effective method for repair of perineal hernia.
October 2017: Asian Journal of Urology
https://www.readbyqxmd.com/read/29380518/ocular-anatomy-of-the-black-pacu-colossoma-macropomum-gross-histologic-and-diagnostic-imaging
#13
Kate A Gustavsen, Joanne R Paul-Murphy, Ernest Scott Weber, Allison L Zwingenberger, Freeland H Dunker, Richard R Dubielzig, Christopher M Reilly, Christopher J Murphy
OBJECTIVE: To describe the ocular anatomy of the black pacu (Colossoma macropomum), a freshwater teleost fish of the Amazon River basin, including an unusual choroid laden with adipose tissue. PROCEDURES: Three adult black pacu were anesthetized and examined clinically and with ocular ultrasonography, then euthanized. Three fish were euthanized and their heads imaged immediately postmortem using computed tomography. One fish was euthanized and its exenterated eyes imaged by high-resolution magnetic resonance imaging...
January 30, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29380107/prognostic-role-of-mesenteric-lymph-nodes-involvement-in-patients-undergoing-posterior-pelvic-exenteration-during-radical-or-supra-radical-surgery-for-advanced-ovarian-cancer
#14
Roberto Berretta, Vito Andrea Capozzi, Giulio Sozzi, Lavinia Volpi, Valentina Ceni, Mauro Melpignano, Giovanna Giordano, Federico Marchesi, Michela Monica, Maurizio Di Serio, Matteo Riccò, Marcello Ceccaroni
PURPOSE: The aim of this retrospective study is to analyze the prognostic role and the practical implication of mesenteric lymph nodes (MLN) involvements in advanced ovarian cancer (AOC). METHODS: A total of 429 patients with AOC underwent surgery between December 2007 and May 2017. We included in the study 83 patients who had primary (PDS) or interval debulking surgery (IDS) for AOC with bowel resection. Numbers, characteristics and surgical implication of MLN involvement were considered...
January 27, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29362344/-a-case-of-rectal-cancer-with-multiple-pulmonary-and-liver-metastases-could-be-resected-through-chemotherapy
#15
Masatoshi Nomura, Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Taishi Hata, Chu Matsuda, Hirofumi Yamamoto, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori
The patient was a 47-year-old man, whose chief complaint was melena. He visited a nearby hospital, and further evaluation showed rectal cancer invading the prostate, with multiple lung and liver metastases. The clinical diagnosis was cT4b(prostate), cN1, cM1b(H2, PUL2), cStage IV . We performed colostomy in the transverse colon prior to chemotherapy. He was administered 1 course of mFOLFOX6 plus bevacizumab and 7 courses of FOLFOXIRI plus bevacizumab. The primary tumor showed PR. The liver metastases were localized and shrunken, while the lung metastases disappeared...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29348987/rhino-orbital-cerebral-mucormycosis-a-fatal-complication-of-uncontrolled-diabetes-mellitus
#16
Purva Bavikar, Varshil Mehta
Mucormycosis is a progressively invasive disease, with a fatal outcome, on late presentation. A 38-year-old female presented with diabetic ketoacidosis with right eye ptosis and a frozen globe without any signs of inflammation, externally. She underwent transnasal endoscopic debridement of paranasal sinuses and exenteration of the right eye. The histopathology specimen revealed the growth of mucormycosis. She was treated with intravenous (IV) amphotericin B, IV insulin, and extensive debridement surgery, but had an unfavorable outcome due to rapid mucor invasion to the brain...
November 13, 2017: Curēus
https://www.readbyqxmd.com/read/29344484/adenocarcinoma-of-the-retinal-pigment-epithelium-arising-in-conjunction-with-late-recurrence-and-systemic-metastasis-of-retinoblastoma
#17
Kelsey Roelofs, Femida Kherani, Laurie Russell, J Godfrey Heathcote, Ezekiel Weis
In 1974, an 8-month-old male was diagnosed with bilateral retinoblastoma. His left eye was enucleated, while the right eye was salvaged with a combination of external beam radiotherapy (4,000 cGy total, divided in 20 fractions) and retinal laser treatment. Thirty-nine years later, he developed intraocular recurrence of retinoblastoma with extrascleral spread. Histopathological examination also identified a second distinct malignancy, retinal pigment epithelium adenocarcinoma, arising in continuity with the retinoblastoma...
November 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344479/mechanisms-of-optic-nerve-invasion-in-primary-choroidal-melanoma
#18
Eszter Szalai, Jill R Wells, Hans E Grossniklaus
Aim: The aim of this study was to assess morphological risk factors associated with optic nerve invasion of choroidal melanoma and to identify possible mechanisms of optic nerve invasion. Methods: Medical charts and histology slides of patients with primary choroidal melanoma who were treated by enucleation/exenteration and whose pathology showed optic nerve invasion were reviewed. Results: Twenty-one patients (mean age: 65.67 ± 14.72 years) with primary uveal melanoma arising from the choroid were included in this analysis...
November 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29341035/when-an-unexpected-diagnosis-occurs-a-vaginal-premenopausal-sarcoma
#19
Pedro Marcos-Figueiredo, Diana de Sousa da Costa Moreira, Manuel Gonçalves Morim, Júlia Leite Pereira, Lurdes Silva Salgado
Vaginal cancer is a rare entity. The evidence on its management resides mostly in clinical cases or small case series. Of the histological types, the most frequent is the squamous cell carcinoma, followed by adenocarcinoma. But what to do when identifying an even more infrequent sarcoma in a premenopausal woman? In this study, we describe the case of a 53-year-old woman presenting with metrorrhagia for two months, who was evaluated after an intense episode. A necrotic and ulcerative vaginal swelling was documented and then submitted to biopsy, which revealed a vaginal sarcoma...
January 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29337772/salvage-surgery-for-locoregional-failure-in-anal-squamous-cell-carcinoma
#20
Glen R Guerra, Joseph C Kong, Maria-Pia Bernardi, Robert G Ramsay, Wayne A Phillips, Satish K Warrier, A Craig Lynch, Samuel Y Ngan, Alexander G Heriot
BACKGROUND: Anal squamous cell carcinoma is a rare cancer with a high cure rate, making research into the treatment of locoregional failure difficult. OBJECTIVE: The purpose of this study was to examine factors related to local treatment failure and determine the outcomes of patients undergoing local salvage resection. DESIGN: This was a retrospective cohort study. SETTING: This study was conducted at a quaternary referral center...
February 2018: Diseases of the Colon and Rectum
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