keyword
https://read.qxmd.com/read/38536026/pelvic-exenteration-a-retrospective-study-in-a-tertiary-referral-cancer-center-in-the-uk
#1
JOURNAL ARTICLE
Konstantinos Palaiologos, Rebecca Karkia, Zoi Nikoloudaki, Ahmed Mohamed, Rebecca Lavelle, Susanne Booth, Marina Flynn, Christopher Helbren, Matthew Simms, Theo Giannopoulos
BACKGROUND: Pelvic exenteration (PE) is an extensive surgery that is indicated in cases of recurrent advanced gynecological cancer with curative and sometimes palliative intent. The procedure is associated with both high morbidity and mortality and as such is considered a highly specialist procedure. The aim of the study was to analyze surgical outcomes in women who underwent PE for advanced gynecological malignancy in a tertiary cancer referral center over 11 years. METHODS: This is an observational retrospective single-center study...
March 27, 2024: Minerva obstetrics and gynecology
https://read.qxmd.com/read/38532591/-clinical-efficacy-of-autologous-biological-patch-in-preventing-rectovaginal-fistula-after-pelvic-exenteration
#2
JOURNAL ARTICLE
Y Wang, Q H Yan, G C Wang, T Wang, C Q Gao, L J Li, L L Ding, Z Zhang, C Wang, Y Zhang, Z C Qi
No abstract text is available yet for this article.
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38514099/rectal-sparing-in-modified-posterior-exenteration-description-of-the-technique-in-10-steps
#3
JOURNAL ARTICLE
Navid Mokarram Dorri, Guillaume Blache, Jonathan Garnier, Gilles Houvenaeghel, Houssein El Hajj, Eric Lambaudie
No abstract text is available yet for this article.
March 21, 2024: International Journal of Gynecological Cancer
https://read.qxmd.com/read/38513708/reconstruction-of-orbital-exenteration-defects-with-cross-median-forehead-flaps
#4
JOURNAL ARTICLE
Sven H Baum, Mohammad Al-Bayati, Christopher Mohr, Roman Pförtner
The aim of this study was to examine the role of forehead flaps in the reconstruction of orbital defects after exenteration. Patients undergoing orbital exenteration and reconstruction using median forehead flaps from January 2002 to August 2019 were enrolled in this retrospective study. All the patients were evaluated for wound complications, functional results, and tumor relapse. In total, 105 patients completed the study. Twenty-nine complications in 24 of these patients were assessed. The most common complications were wound dehiscence (11%), partial necrosis of the flap (6%), and bleeding (4%)...
March 21, 2024: Facial Plastic Surgery: FPS
https://read.qxmd.com/read/38505337/rare-case-of-strangulated-primary-acquired-perineal-hernia-causing-small-bowel-obstruction-requiring-emergency-operative-repair
#5
Giuleta Jamsari, Charlotte Kwik, Jenny King, Nimalan Pathma-Nathan
Primary acquired perineal hernia is rare with only 100 reported cases in the literature. Emergency presentations of intestinal obstruction secondary to perineal hernia are very rare and to-date, there are only eight cases reported in the literature. We present a case of a 74-year-old lady who presented with a small bowel obstruction secondary to strangulated perineal hernia in the absence of pelvic exenteration or abdominoperineal resection requiring operative repair via combined open transabdominal and transperineal approach...
March 2024: Journal of Surgical Case Reports
https://read.qxmd.com/read/38497054/combining-surgery-radiotherapy-and-topical-chemotherapy-to-prevent-primary-orbital-exenteration-for-atypical-caruncular-melanoma-a-case-report
#6
Cédric De Landsheer, Valentien Merlevede, Celine Jacobs, Jo Van Dorpe, Julie De Zaeytijd, Virginie G S Ninclaus, Dimitri Roels
INTRODUCTION: This case report demonstrates the possibility of successful eye and vision-sparing therapy for caruncular melanoma. CASE PRESENTATION: We present an atypical presentation of a caruncular melanoma. After excisional biopsy, residual flat conjunctival melanosis resolved using topical chemotherapy (5-fluorouracil), which was well tolerated. Relapse of the melanoma was treated with external beam radiotherapy, but the tumor grew despite treatment. Eighteen months after complete excision of the relapsed melanoma, the patient remains tumor-free while the eye and its function remain preserved...
2024: Case Reports in Ophthalmology
https://read.qxmd.com/read/38482226/retrospective-study-of-combined-pelvic-exenteration-in-the-treatment-of-primary-and-recurrent-pelvic-malignant-tumors
#7
JOURNAL ARTICLE
Changzheng Li, Zhenyu Li, Jiachen Zhang, Xijie Zhang, Gabriele Siesto, Sen Li, Pengfei Ma, Junli Zhang, Zhi Li, Yuzhou Zhao
BACKGROUND: Pelvic malignant tumors often originate in the rectum, bladder, uterus, and other organs. In patients with locally advanced tumours in the presence of direct invasion of one or more organs, negative tumor resection margin (R0) resection can be very beneficial to patient survival if it can be performed. As a multidisciplinary and high-risk surgical method, the pelvic exenteration (PE) procedure has only been reported in a few medical centres internationally. We retrospectively analyzed the clinical data of patients who had undergone PE surgery in our hospital, in order to provide ideas for the best treatment of patients with pelvic malignant tumors...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38475933/surgical-and-survival-outcomes-of-early-onset-colorectal-cancer-patients-a-single-centre-descriptive-australian-study
#8
JOURNAL ARTICLE
Celine Garrett, Daniel Steffens, Michael Solomon, Cherry Koh
BACKGROUND: Early-onset colorectal cancer (EOCRC) incidence is increasing in Australia. However, no Australian studies have reported on EOCRC patients' surgical management and survival patterns. METHODS: A retrospective study of 111 EOCRC patients treated at the Royal Prince Alfred Hospital (RPAH), Sydney, Australia between January 2013 and December 2021 was performed. RPAH is a quaternary referral centre for pelvic exenteration (PE) and cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC)...
March 12, 2024: ANZ Journal of Surgery
https://read.qxmd.com/read/38462378/-a-giant-malignant-melanoma-of-the-palpebral-conjunctiva-a-case-report
#9
JOURNAL ARTICLE
X H Zhang, Z Yang, Y Lu, Z H Feng
An 81-year-old female patient experienced a rapid increase in the volume of a rice-sized black mass on the left eye over a period of six months. The mass extended out of the eye and exhibited surface erosion with accompanying hemorrhage. Following a live tissue examination and histopathology after orbital exenteration under general anesthesia, the diagnosis of a giant malignant palpebral conjunctival melanoma of the spindle cell subtype was confirmed. The patient refused to undergo local radiation therapy or systemic chemotherapy and died from the disease six months later...
March 11, 2024: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://read.qxmd.com/read/38456677/the-empty-pelvis-syndrome-a-core-data-set-from-the-pelvex-collaborative
#10
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Empty pelvis syndrome (EPS) is a significant source of morbidity following pelvic exenteration (PE), but is undefined. EPS outcome reporting and descriptors of radicality of PE are inconsistent; therefore, the best approaches for prevention are unknown. To facilitate future research into EPS, the aim of this study is to define a measurable core outcome set, core descriptor set and written definition for EPS. Consensus on strategies to mitigate EPS was also explored. METHOD: Three-stage consensus methodology was used: longlisting with systematic review, healthcare professional event, patient engagement, and Delphi-piloting; shortlisting with two rounds of modified Delphi; and a confirmatory stage using a modified nominal group technique...
March 2, 2024: British Journal of Surgery
https://read.qxmd.com/read/38456099/advanced-periocular-basal-cell-carcinoma-with-orbital-invasion-update-on-management-and-treatment-advances
#11
JOURNAL ARTICLE
Alvaro Bengoa-González, Enrique Mencía-Gutiérrez, María Garrido, Elena Salvador, María-Dolores Lago-Llinás
PURPOSE: Basal cell carcinoma (BCC) is the most frequent malignant periocular tumor. It is associated with exposure to ultraviolet radiation, and its incidence is gradually increasing. It may occasionally display more aggressive behavior and result in orbital or intracranial invasion. Mortality from periocular BBC with orbital invasion is very low, but the associated morbidity can be significant, from disfigurement to blindness. Traditionally, these cases have been treated with orbital exenteration or with radiotherapy (RT), but in recent years, hedgehog pathway inhibitors (HPIs) have emerged, are effective in more serious cases, and are used primarily or combined with surgery, changing our perspective on the management of these patients...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38454866/clinicodemographic-profile-of-orbital-exenteration-in-a-tertiary-eye-care-center-a-20-year-experience
#12
JOURNAL ARTICLE
Rachna Meel, Neelam Pushker, Shweta Das Chaurasia, Aishwarya Rathod, Mandeep Singh Bajaj, Seema Sen, Sahil Agrawal
PURPOSE: This study aimed to determine the clinical indications for orbital exenteration, demographic profile of these patients, and clinicopathologic correlations in the current times and to compare these results with previous published data. METHODS: It was a retrospective study. All exenterations performed at a tertiary eye care center over a period of 20 years (from January 2001 to June 2020) were retrospectively evaluated. Patient records were reviewed to obtain demographic data, presenting symptoms and their duration, laterality, and clinical and histopathologic diagnosis...
March 8, 2024: Indian Journal of Ophthalmology
https://read.qxmd.com/read/38438169/trends-and-current-aspects-of-reconstructive-surgery-for-gynecological-cancers
#13
REVIEW
Matteo Loverro, Alessia Aloisi, Lucia Tortorella, Giovanni Damiano Aletti, Amanika Kumar
Gynecologic cancers can lead to gynecologic tract destruction with extension into both the gastrointestinal and urinary tracts. Recurrent disease can also affect the surrounding bony pelvis and pelvic musculature. As opposed to advanced ovarian cancer, where cytoreduction is the goal, in these scenarios, an oncologic approach to achieve negative margins is critical for benefit. Surgeries aimed at achieving a R0 resection in gynecologic oncology can have a significant impact on pelvic anatomy, and require reconstruction...
March 4, 2024: International Journal of Gynecological Cancer
https://read.qxmd.com/read/38418597/-palliative-surgery-for-metastatic-prostate-cancer
#14
REVIEW
Axel Heidenreich, Christian Bach, David Pfister
Androgen deprivation in combination with novel hormonal agents, docetaxel, or in combination with abiraterone/prednisone plus docetaxel or darolutamid plus docetaxel represent the standard therapeutic approach in metastatic hormone-sensitive prostate cancer (mHSPC). Patients with low-risk prostate cancer also benefit from additional radiation therapy or radical prostatectomy in terms of progression-free and overall survival. Despite favorable response rates, basically all patients will develop castration resistant prostate cancer (CRPC) within 2...
February 28, 2024: Urologie
https://read.qxmd.com/read/38410226/current-status-of-robot-assisted-total-pelvic-exenteration-focusing-on-the-field-of-urology-a-clinical-practice-review
#15
REVIEW
Jun Kamei, Tetsuya Fujimura
Total pelvic exenteration (TPE) is a highly invasive surgery associated with high rates of perioperative morbidity and mortality and is commonly performed for several types of locally advanced or recurrent pelvic cancers. It involves multivisceral resection, including the rectum, sigmoid colon, bladder, prostate, uterus, vagina, or ovaries, and urologists normally perform radical cystectomy or radical prostatectomy and urinary diversion in collaboration with colorectal surgeons and gynecologists. In the urological field, robot-assisted surgeries have been widely performed as one of the main minimally invasive procedures because of their superior perioperative or oncological outcomes compared to open or laparoscopic surgeries...
January 31, 2024: Translational Cancer Research
https://read.qxmd.com/read/38408876/outcomes-following-pelvic-exenteration-for-locally-recurrent-rectal-cancer-with-and-without-en-bloc-sacrectomy
#16
JOURNAL ARTICLE
Jacob H Waller, Charlotte S Van Kessel, Michael J Solomon, Peter J Lee, Kirk K S Austin, Daniel Steffens
BACKGROUND: Extended radical resection is often the only chance of cure for locally recurrent rectal cancer. Recurrence in the posterior compartment often necessitates en bloc sacrectomy as part of pelvic exenteration in order to obtain clear resection margins and provide survival benefit. OBJECTIVE: To compare oncological, morbidity and quality of life outcomes, following pelvic exenteration with and without en bloc sacrectomy for recurrent rectal cancer. DESIGN: Comparative Cohort study with retrospective analysis of prospectively collected data...
February 23, 2024: Diseases of the Colon and Rectum
https://read.qxmd.com/read/38398208/the-role-of-pelvic-exenteration-in-cervical-cancer-a-review-of-the-literature
#17
REVIEW
Ana Carla Franco Ubinha, Priscila Grecca Pedrão, Aline Cássia Tadini, Ronaldo Luis Schmidt, Marcelo Henrique Dos Santos, Carlos Eduardo Mattos da Cunha Andrade, Adhemar Longatto Filho, Ricardo Dos Reis
Pelvic exenteration represents a radical procedure aimed at achieving complete tumor resection with negative margins. Although it is the only therapeutic option for some cases of advanced tumors, it is associated with several perioperative complications. We believe that careful patient selection is related to better oncologic outcomes and lower complication rates. The objectives of this review are to identify the most current indications for this intervention, suggest criteria for case selection, evaluate recommendations for perioperative care, and review oncologic outcomes and potential associated complications...
February 18, 2024: Cancers
https://read.qxmd.com/read/38380808/impact-of-intraoperative-decision-making-on-pathological-margin-status-in-patients-undergoing-pelvic-exenteration-for-locally-recurrent-rectal-cancer
#18
JOURNAL ARTICLE
Nargus Ebrahimi, Kilian G M Brown, Kheng-Seong Ng, Michael J Solomon, Peter J Lee
BACKGROUND: A key component of preoperative preparation for pelvic exenteration surgery is development of an operative plan in a multidisciplinary setting, based on the extent of local tumor invasion on preoperative imaging. Changes to the extent of resection or operative plan may occur intraoperatively based on intraoperative findings. OBJECTIVE: To report the frequency and extent of intraoperative deviation from the planned extent of resection during pelvic exenteration for locally recurrent rectal cancer, and whether this resulted in a more or less radical resection...
February 21, 2024: Diseases of the Colon and Rectum
https://read.qxmd.com/read/38379076/comparison-of-urological-outcomes-and-quality-of-life-after-pelvic-exenteration-partial-vs-radical-cystectomy
#19
JOURNAL ARTICLE
Charlotte S van Kessel, Catalina A Palma, Michael J Solomon, Scott Leslie, Nicola Jeffery, Peter J Lee, Kirk K S Austin
OBJECTIVE: To compare perioperative morbidity, functional and quality-of-life (QoL) outcomes in patients with partial cystectomy vs radical cystectomy as part of pelvic exenteration. PATIENTS AND METHODS: Retrospective analysis of a prospectively maintained database of pelvic exenteration patients (1998-2021) was conducted in a single centre. Study outcomes included postoperative complications, quality-of-life, functional and stoma-related outcomes. The 36-item Short-Form Health Survey Physical and Mental Health Components, Functional Assessment of Cancer Therapy-Colorectal questionnaires and Distress Thermometer were available pre- and postoperatively...
February 20, 2024: BJU International
https://read.qxmd.com/read/38370592/appendiceal-ganglioneuroma-incidentally-found-during-resection-of-recurrent-rectal-cancer-case-report-and-review-of-the-literature
#20
Mauricio E Perez Pachon, Rachel Horton, Kristen K Rumer
Ganglioneuromas (GN) are benign neuroblastic tumors that arise from neural crest cells. Since they present with nonspecific symptoms, diagnosis is often incidental. We are reporting a case of an adult appendiceal GN incidentally found during rectal cancer surgery. A 42-year-old male was diagnosed with recurrent rectal cancer after experiencing urinary difficulties and buttock pain. A multiple-stage pelvic exenteration was carried out after neoadjuvant chemotherapy and chemoradiation. Prophylactic appendectomy was done during the course of surgery, and pathology reported an appendix with GN at the distal tip...
February 2024: Journal of Surgical Case Reports
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