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https://www.readbyqxmd.com/read/28049075/abnormal-brain-oscillations-persist-after-recovery-from-bipolar-depression
#1
P Canali, S Casarotto, M Rosanova, G Sferrazza-Papa, A G Casali, O Gosseries, M Massimini, E Smeraldi, C Colombo, F Benedetti
When directly perturbed in healthy subjects, premotor cortical areas generate electrical oscillations in the beta range (20-40Hz). In schizophrenia, major depressive disorder and bipolar disorder (BD), these oscillations are markedly reduced, in terms of amplitude and frequency. However, it still remains unclear whether these abnormalities can be modulated over time, or if they can be still observed after treatment. Here, we employed transcranial magnetic stimulation (TMS) combined with EEG to assess the frontal oscillatory activity in eighteen BD patients before/after antidepressant treatments (sleep deprivation and light therapy), relative to nine healthy controls...
December 27, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28008690/heavy-alcohol-use-in-adolescence-is-associated-with-altered-cortical-activity-a-combined-tms-eeg-study
#2
Outi Kaarre, Elisa Kallioniemi, Mervi Könönen, Tommi Tolmunen, Virve Kekkonen, Petri Kivimäki, Noora Heikkinen, Florinda Ferreri, Eila Laukkanen, Sara Määttä
Long-term alcohol use affects cognitive and neurophysiological functioning as well as structural brain development. Combining simultaneous electroencephalogram (EEG) recording with transcranial magnetic stimulation (TMS) enables direct, in vivo exploration of cortical excitability and assessment of effective and functional connectivity. In the central nervous system, the effects of alcohol are particularly mediated by alterations in gamma-aminobutyric acid (GABA)ergic neurotransmission, and TMS-evoked potentials (TEPs) N45 and N100 in EEG are known to reflect GABAergic function...
December 23, 2016: Addiction Biology
https://www.readbyqxmd.com/read/28007469/tms-combined-with-eeg-in-genetic-generalized-epilepsy-a-phase-ii-diagnostic-accuracy-study
#3
Vasilios K Kimiskidis, Alkiviadis Tsimpiris, Philippe Ryvlin, Reetta Kalviainen, Michalis Koutroumanidis, Antonio Valentin, Nikolaos Laskaris, Dimitris Kugiumtzis
OBJECTIVES: (A) To develop a TMS-EEG stimulation and data analysis protocol in genetic generalized epilepsy (GGE). (B) To investigate the diagnostic accuracy of TMS-EEG in GGE. METHODS: Pilot experiments resulted in the development and optimization of a paired-pulse TMS-EEG protocol at rest, during hyperventilation (HV), and post-HV combined with multi-level data analysis. This protocol was applied in 11 controls (C) and 25 GGE patients (P), further dichotomized into responders to antiepileptic drugs (R, n=13) and non-responders (n-R, n=12)...
November 24, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27965543/controllable-pulse-parameter-tms-and-tms-eeg-as-novel-approaches-to-improve-neural-targeting-with-rtms-in-human-cerebral-cortex
#4
Ricci Hannah, Lorenzo Rocchi, Sara Tremblay, John C Rothwell
No abstract text is available yet for this article.
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27927951/effects-of-the-selective-%C3%AE-5-gabaar-antagonist-s44819-on-excitability-in-the-human-brain-a-tms-emg-and-tms-eeg-phase-i-study
#5
Ghazaleh Darmani, Carl M Zipser, Gabriele M Böhmer, Karine Deschet, Florian Müller-Dahlhaus, Paolo Belardinelli, Matthias Schwab, Ulf Ziemann
: Alpha-5 gamma-aminobutyric acid type A receptors (α5-GABAARs) are located extrasynaptically, regulate neuronal excitability through tonic inhibition, and are fundamentally important for processes such as plasticity and learning. For example, pharmacological blockade of α5-GABAAR in mice with ischemic stroke improved recovery of function by normalizing exaggerated perilesional α5-GABAAR-dependent tonic inhibition. S44819 is a novel competitive selective antagonist of the α5-GABAAR at the GABA-binding site...
December 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27812319/evaluating-the-effect-of-repetitive-transcranial-magnetic-stimulation-on-disorders-of-consciousness-by-using-tms-eeg
#6
Yang Bai, Xiaoyu Xia, Jiannan Kang, Xiaoxiao Yin, Yi Yang, Jianghong He, Xiaoli Li
Background: The modulation efficacy of Transcranial magnetic stimulation (TMS) on consciousness improvement of patient with disorder of consciousness (DOC) has not been definitely confirmed. Objective: This study proposes TMS-EEG to assess effects of repetitive TMS (rTMS) on brain modulation of DOC. Methods: Twenty sessions of 10 Hz rTMS were applied over the dorsolateral prefrontal cortex for a patient with DOC. Measures of Coma Recovery Scale-Revised (CRS-R) score, TMS-evoked potential (TEP), perturbation complexity index (PCI), and global mean field power (GMFP) were used to evaluate the consciousness level of the patient at three intervals: before the rTMS protocol (T0), immediately after one session rTMS (T1), and immediately after 20 sessions (T2)...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27808418/lamotrigine-and-levetiracetam-exert-a-similar-modulation-of-tms-evoked-eeg-potentials
#7
Isabella Premoli, Andrea Biondi, Sara Carlesso, Davide Rivolta, Mark P Richardson
OBJECTIVE: Antiepileptic drug (AED) treatment failures may occur because there is insufficient drug in the brain or because of a lack of relevant therapeutic response. Until now it has not been possible to measure these factors. It has been recently shown that the combination of transcranial magnetic stimulation and electroencephalography (TMS-EEG) can measure the effects of drugs in healthy volunteers. TMS-evoked EEG potentials (TEPs) comprise a series of positive and negative deflections that can be specifically modulated by drugs with a well-known mode of action targeting inhibitory neurotransmission...
January 2017: Epilepsia
https://www.readbyqxmd.com/read/27789211/corrigendum-to-brain-activity-underlying-visual-perception-and-attention-as-inferred-from-tms-eeg-a-review-brain-stimulation-5-2012-124-129
#8
Paul C Taylor, Gregor Thut
No abstract text is available yet for this article.
October 17, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27788128/reduction-hybrid-artifacts-of-emg-eog-in-electroencephalography-evoked-by-prefrontal-transcranial-magnetic-stimulation
#9
Yang Bai, Xiaohong Wan, Ke Zeng, Yinmei Ni, Lirong Qiu, Xiaoli Li
OBJECTIVE: When prefrontal-transcranial magnetic stimulation (p-TMS) performed, it may evoke hybrid artifact mixed with muscle activity and blink activity in EEG recordings. Reducing this kind of hybrid artifact challenges the traditional preprocessing methods. We aim to explore method for the p-TMS evoked hybrid artifact removal. APPROACH: We propose a novel method used as independent component analysis (ICA) post processing to reduce the p-TMS evoked hybrid artifact...
December 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27774054/tmseeg-a-matlab-based-graphical-user-interface-for-processing-electrophysiological-signals-during-transcranial-magnetic-stimulation
#10
Sravya Atluri, Matthew Frehlich, Ye Mei, Luis Garcia Dominguez, Nigel C Rogasch, Willy Wong, Zafiris J Daskalakis, Faranak Farzan
Concurrent recording of electroencephalography (EEG) during transcranial magnetic stimulation (TMS) is an emerging and powerful tool for studying brain health and function. Despite a growing interest in adaptation of TMS-EEG across neuroscience disciplines, its widespread utility is limited by signal processing challenges. These challenges arise due to the nature of TMS and the sensitivity of EEG to artifacts that often mask TMS-evoked potentials (TEP)s. With an increase in the complexity of data processing methods and a growing interest in multi-site data integration, analysis of TMS-EEG data requires the development of a standardized method to recover TEPs from various sources of artifacts...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27771347/analysing-concurrent-transcranial-magnetic-stimulation-and-electroencephalographic-data-a-review-and-introduction-to-the-open-source-tesa-software
#11
Nigel C Rogasch, Caley Sullivan, Richard H Thomson, Nathan S Rose, Neil W Bailey, Paul B Fitzgerald, Faranak Farzan, Julio C Hernandez-Pavon
The concurrent use of transcranial magnetic stimulation with electroencephalography (TMS-EEG) is growing in popularity as a method for assessing various cortical properties such as excitability, oscillations and connectivity. However, this combination of methods is technically challenging, resulting in artifacts both during recording and following typical EEG analysis methods, which can distort the underlying neural signal. In this article, we review the causes of artifacts in EEG recordings resulting from TMS, as well as artifacts introduced during analysis (e...
October 19, 2016: NeuroImage
https://www.readbyqxmd.com/read/27769831/corrigendum-to-the-right-angular-gyrus-combines-perceptual-and-response-related-expectancies-in-visual-search-tms-eeg-evidence-brain-stimulation-8-2015-816-22
#12
Francesca Bocca, Thomas Töllner, Hermann J Müller, Paul C Taylor
No abstract text is available yet for this article.
October 14, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27713691/characterizing-and-modulating-brain-circuitry-through-transcranial-magnetic-stimulation-combined-with-electroencephalography
#13
Faranak Farzan, Marine Vernet, Mouhsin M D Shafi, Alexander Rotenberg, Zafiris J Daskalakis, Alvaro Pascual-Leone
The concurrent combination of transcranial magnetic stimulation (TMS) with electroencephalography (TMS-EEG) is a powerful technology for characterizing and modulating brain networks across developmental, behavioral, and disease states. Given the global initiatives in mapping the human brain, recognition of the utility of this technique is growing across neuroscience disciplines. Importantly, TMS-EEG offers translational biomarkers that can be applied in health and disease, across the lifespan, and in humans and animals, bridging the gap between animal models and human studies...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27660540/exploring-cortical-plasticity-and-oscillatory-brain-dynamics-via-transcranial-magnetic-stimulation-and-resting-state-electroencephalogram
#14
REVIEW
Nor Azila Noh
Transcranial magnetic stimulation (TMS) is a non-invasive, non-pharmacological technique that is able to modulate cortical activity beyond the stimulation period. The residual aftereffects are akin to the plasticity mechanism of the brain and suggest the potential use of TMS for therapy. For years, TMS has been shown to transiently improve symptoms of neuropsychiatric disorders, but the underlying neural correlates remain elusive. Recently, there is evidence that altered connectivity of brain network dynamics is the mechanism underlying symptoms of various neuropsychiatric illnesses...
July 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/27570187/investigating-tms-eeg-indices-of-long-interval-intracortical-inhibition-at-different-interstimulus-intervals
#15
George M Opie, Nigel C Rogasch, Mitchell R Goldsworthy, Michael C Ridding, John G Semmler
BACKGROUND: Long-interval intracortical inhibition (LICI) is a transcranial magnetic stimulation (TMS) paradigm that uses paired magnetic stimuli separated by 100-200 ms to investigate the activity of cortical GABAergic interneurons. While commonly applied, the mechanisms contributing to LICI are not well understood, and growing evidence suggests that inhibition observed at different interstimulus intervals (ISI) may involve non-identical processes. OBJECTIVE: This study aims to utilise combined TMS-EEG to more thoroughly characterise LICI at different ISIs, as the TMS-evoked EEG potential (TEP) can provide more direct insight into the cortical response to stimulation that is not subject to variations in spinal cord excitability that can confound the motor evoked potential (MEP)...
August 8, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27529410/fractionation-of-parietal-function-in-bistable-perception-probed-with-concurrent-tms-eeg
#16
Georg Schauer, Acer Chang, David Schwartzman, Charlotte L Rae, Heather Iriye, Anil K Seth, Ryota Kanai
When visual input has conflicting interpretations, conscious perception can alternate spontaneously between these possible interpretations. This is called bistable perception. Previous neuroimaging studies have indicated the involvement of two right parietal areas in resolving perceptual ambiguity (ant-SPLr and post-SPLr). Transcranial magnetic stimulation (TMS) studies that selectively interfered with the normal function of these regions suggest that they play opposing roles in this type of perceptual switch...
August 16, 2016: Scientific Data
https://www.readbyqxmd.com/read/27491799/consciousness-and-cortical-responsiveness-a-within-state-study-during-non-rapid-eye-movement-sleep
#17
Jaakko O Nieminen, Olivia Gosseries, Marcello Massimini, Elyana Saad, Andrew D Sheldon, Melanie Boly, Francesca Siclari, Bradley R Postle, Giulio Tononi
When subjects become unconscious, there is a characteristic change in the way the cerebral cortex responds to perturbations, as can be assessed using transcranial magnetic stimulation and electroencephalography (TMS-EEG). For instance, compared to wakefulness, during non-rapid eye movement (NREM) sleep TMS elicits a larger positive-negative wave, fewer phase-locked oscillations, and an overall simpler response. However, many physiological variables also change when subjects go from wake to sleep, anesthesia, or coma...
August 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27488504/resting-state-brain-dynamics-and-its-transients-a-combined-tms-eeg-study
#18
Mireille Bonnard, Sophie Chen, Jérôme Gaychet, Marcel Carrere, Marmaduke Woodman, Bernard Giusiano, Viktor Jirsa
The brain at rest exhibits a spatio-temporally rich dynamics which adheres to systematic behaviours that persist in task paradigms but appear altered in disease. Despite this hypothesis, many rest state paradigms do not act directly upon the rest state and therefore cannot confirm hypotheses about its mechanisms. To address this challenge, we combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to study brain's relaxation toward rest following a transient perturbation. Specifically, TMS targeted either the medial prefrontal cortex (MPFC), i...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27461082/characterization-of-glutamatergic-and-gabaa-mediated-neurotransmission-in-motor-and-dorsolateral-prefrontal-cortex-using-paired-pulse-tms-eeg
#19
Robin F H Cash, Yoshihiro Noda, Reza Zomorrodi, Natasha Radhu, Faranak Farzan, Tarek K Rajji, Paul B Fitzgerald, Robert Chen, Zafiris J Daskalakis, Daniel M Blumberger
Short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) are noninvasive transcranial magnetic stimulation (TMS) measures of GABAA receptor-mediated inhibition and glutamatergic excitatory transmission, respectively. Conventionally these measures have been restricted to the motor cortex. We investigated whether SICI and ICF could be recorded from the dorsolateral prefrontal cortex (DLPFC) using combined TMS and electroencephalography (TMS-EEG). We first characterized the neural signature of SICI and ICF in M1 in terms of TMS-evoked potentials (TEPs) and spectral power modulation...
January 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27291496/recovering-tms-evoked-eeg-responses-masked-by-muscle-artifacts
#20
Tuomas P Mutanen, Matleena Kukkonen, Jaakko O Nieminen, Matti Stenroos, Jukka Sarvas, Risto J Ilmoniemi
Combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) often suffers from large muscle artifacts. Muscle artifacts can be removed using signal-space projection (SSP), but this can make the visual interpretation of the remaining EEG data difficult. We suggest to use an additional step after SSP that we call source-informed reconstruction (SIR). SSP-SIR improves substantially the signal quality of artifactual TMS-EEG data, causing minimal distortion in the neuronal signal components...
June 9, 2016: NeuroImage
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