keyword
https://read.qxmd.com/read/38478584/loxapine-inhibits-replication-of-hepatitis-a-virus-in-vitro-and-in-vivo-by-targeting-viral-protein-2c
#1
JOURNAL ARTICLE
Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani, Michiyo Kataoka, Xin Zheng, Daisuke Yamane, Masaru Yokoyama, Koji Ishii, Masamichi Muramatsu, Ryosuke Suzuki
No antiviral drugs currently are available for treatment of infection by hepatitis A virus (HAV), a causative agent of acute hepatitis, a potentially life-threatening disease. Chemical screening of a small-compound library using nanoluciferase-expressing HAV identified loxapine succinate, a selective dopamine receptor D2 antagonist, as a potent inhibitor of HAV propagation in vitro. Loxapine succinate did not inhibit viral entry nor internal ribosome entry site (IRES)-dependent translation, but exhibited strong inhibition of viral RNA replication...
March 13, 2024: PLoS Pathogens
https://read.qxmd.com/read/38445139/a-naturalistic-non-interventional-investigation-of-the-clinical-and-sociodemographic-characteristics-and-prescription-patterns-in-patients-with-psychotic-disorders-at-a-tertiary-care-facility-in-south-asia
#2
JOURNAL ARTICLE
Zarrin Ansari, Abhilasha Rashmi, Sudhir Pawar
OBJECTIVES:  This study aimed to evaluate the trends in the sociodemographic, clinical, and prescription characteristics of patients with psychotic illnesses seen in the outpatient psychiatry department of a tertiary care facility. METHODS:  Between March 2021 and April 2022, a cross-sectional, prospective, observational, naturalistic, non-interventional study was conducted. A total of two hundred prescriptions were analyzed. To assess the rationality of prescriptions, World Health Organization (WHO) indicators were also computed...
February 2024: Curēus
https://read.qxmd.com/read/38350720/discovery-of-a-small-molecule-activator-of-slack-kcnt1-potassium-channels-that-significantly-reduces-scratching-in-mouse-models-of-histamine-independent-and-chronic-itch
#3
JOURNAL ARTICLE
Annika Balzulat, W Felix Zhu, Cathrin Flauaus, Victor Hernandez-Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark, Ewgenij Proschak, Achim Schmidtko
Various disorders are accompanied by histamine-independent itching, which is often resistant to the currently available therapies. Here, it is reported that the pharmacological activation of Slack (Kcnt1, KNa 1.1), a potassium channel highly expressed in itch-sensitive sensory neurons, has therapeutic potential for the treatment of itching. Based on the Slack-activating antipsychotic drug, loxapine, a series of new derivatives with improved pharmacodynamic and pharmacokinetic profiles is designed that enables to validate Slack as a pharmacological target in vivo...
February 13, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38315306/first-generation-antipsychotic-associated-serious-adverse-events-in-women-a-retrospective-analysis-of-a-pharmacovigilance-database
#4
JOURNAL ARTICLE
Kenneth L McCall, Bennett J Doughty, Brian J Piper, Heeral Naik, Seraphine Bange, Emily E Leppien
BACKGROUND: Women have been under-represented in trials of antipsychotic medications. AIM: Our primary objective was to evaluate five adverse events (AE) associated with first-generation antipsychotics (FGAs) among women relative to men through an analysis of the FDA Adverse Event Reporting System (FAERS). METHOD: We queried 24.6 million AE reports from 2000 to 2023 involving FGAs. The study cohort consisted of chlorpromazine (n = 3317), fluphenazine (n = 1124), haloperidol (n = 16,709), loxapine (n = 3151), perphenazine (n = 816), thioridazine (n = 665), thiothixene (n = 244), and trifluoperazine (n = 360)...
February 5, 2024: International Journal of Clinical Pharmacy
https://read.qxmd.com/read/38301034/alternative-approaches-for-addressing-acute-agitation-in-schizophrenia-and-bipolar-disorder
#5
REVIEW
Leslie Citrome, Christoph U Correll, Luis San, Scott L Zeller, Stuart Madden, Juan Gutierrez, Miguel Lopez-Toledano, Sunita N Misra, Enrique Carrazana, Adrian L Rabinowicz
Importance: The prompt effective treatment of acute agitation among patients with schizophrenia or bipolar disorder can alleviate distressing symptoms for the patient and decrease the risk of escalation to aggression and the potential for serious harm to the patient, health care providers, and others. Observations: A commonly used approach for the management of acute agitation has been the intramuscular administration of antipsychotic medications and/or benzodiazepines. However, US Food and Drug Administration-approved treatments with alternative routes of delivery now include inhaled loxapine powder and, more recently, dexmedetomidine sublingual film...
January 30, 2024: Primary Care Companion to CNS Disorders
https://read.qxmd.com/read/38134395/efficacy-and-safety-of-loxapine-in-acute-agitation-a-systematic-review-of-interventional-studies
#6
JOURNAL ARTICLE
Camille Lebel, Francky Teddy Endomba, Guillaume Chabridon, Jean-Christophe Chauvet-Gélinier
Objective: To assess the efficacy and safety of loxapine in acute agitation. Data Sources: PubMed, Cochrane database, EMBASE, PsycINFO, and ClinicalTrials.gov were searched to identify relevant articles published in English or French from inception to March 15, 2022. The term "Loxap*" was searched in titles and abstracts. Study Selection and Data Extraction: Interventional studies that compared the effectiveness of loxapine to any other intervention (including another administration route or dosage of loxapine, other drugs, and placebo) in acute agitation were included...
December 19, 2023: Primary Care Companion to CNS Disorders
https://read.qxmd.com/read/38097097/clinical-effectiveness-of-pharmacological-and-non-pharmacological-treatments-for-the-management-of-anxiety-in-community-dwelling-people-living-with-dementia-a-systematic-review-and-meta-analysis
#7
REVIEW
Danielle Nimmons, Narin Aker, Alice Burnand, Kelvin P Jordan, Claudia Cooper, Nathan Davies, Jill Manthorpe, Carolyn A Chew-Graham, Tom Kingstone, Irene Petersen, Kate Walters
People living with dementia commonly experience anxiety, which is often challenging to manage. We investigated the effectiveness of treatments for the management of anxiety in this population. We conducted a systematic review and meta-analysis of randomised controlled trials, and searched EMBASE, CINAHL, MEDLINE and PsycInfo. We estimated standardised mean differences at follow-up between treatments relative to control groups and pooled these across studies using random-effects models where feasible. Thirty-one studies were identified...
February 2024: Neuroscience and Biobehavioral Reviews
https://read.qxmd.com/read/38014294/the-parkinson-s-drug-entacapone-disrupts-gut-microbiome-homeostasis-via-iron-sequestration
#8
Fátima C Pereira, Xiaowei Ge, Jannie Munk Kristensen, Rasmus H Kirkegaard, Klara Maritsch, Yifan Zhu, Marie Decorte, Bela Hausmann, David Berry, Kenneth Wasmund, Arno Schintlmeister, Thomas Boettcher, Ji-Xin Cheng, Michael Wagner
Increasing evidence shows that many human-targeted drugs alter the gut microbiome, leading to implications for host health. However, much less is known about the mechanisms by which drugs target the microbiome and how drugs affect microbial function. Here we combined quantitative microbiome profiling, long-read metagenomics, stable isotope probing and single cell chemical imaging to investigate the impact of two widely prescribed nervous system targeted drugs on the gut microbiome. Ex vivo supplementation of physiologically relevant concentrations of entacapone or loxapine succinate to faecal samples significantly impacted the abundance of up to one third of the microbial species present...
November 13, 2023: bioRxiv
https://read.qxmd.com/read/37990777/dress-to-loxapine-and-avoidable-recurrence-with-clozapine
#9
Ilaria Matei, Amandine Weill, Kamar Bel Hareth, Saskia Ingen-Housz-Oro, Haudrey Assier
No abstract text is available yet for this article.
November 21, 2023: Contact Dermatitis
https://read.qxmd.com/read/37713738/antipsychotic-use-and-28-day-mortality-in-patients-hospitalized-with-covid-19-a-multicenter-observational-retrospective-study
#10
JOURNAL ARTICLE
Marina Sánchez-Rico, Alejandro Edán-Sánchez, Mark Olfson, Jesús M Alvarado, Guillaume Airagnes, Katayoun Rezaei, Aude Delcuze, Hugo Peyre, Frédéric Limosin, Nicolas Hoertel
Prior research has yielded conflicting results about the potential influence of antipsychotics in patients with COVID-19. In this multicenter retrospective study, we examined the association of antipsychotic use at admission with 28-day all-cause mortality in a sample of 59,021 adult patients hospitalized with COVID-19 from January 2020 to November 2021. In a 1:1 ratio matched analytic sample (N=1,454) accounting for age, sex, hospital, hospitalization period, the Elixhauser Comorbidity Index, other psychotropic medications, medications prescribed according to compassionate use or as part of a clinical trial, current diagnoses of psychiatric disorders, and clinical and biological markers of COVID-19 severity, antipsychotic use was not associated with 28-day mortality [23...
June 16, 2023: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/37581475/improving-the-pharmacotherapeutic-treatment-of-agitation-associated-with-bipolar-disorder
#11
REVIEW
Justin Faden, Joseph F Goldberg, Leslie Citrome
INTRODUCTION: Agitation is commonly encountered in people with bipolar disorder, particularly when experiencing a manic episode. The number of approved pharmacological agents to manage acute episodes of agitation in this population is limited. AREAS COVERED: A search was conducted using the US National Library of Medicine PubMed.gov resource for English-language papers of clinical trials and reviews/meta-analyses, using the text words 'bipolar disorder' AND 'agitation,' as well as any papers with both two text words in the title, without any date restrictions...
2023: Expert Opinion on Pharmacotherapy
https://read.qxmd.com/read/37383284/pharmacotherapy-in-autism-spectrum-disorders-including-promising-older-drugs-warranting-trials
#12
REVIEW
Jessica Hellings
Available pharmacotherapies for autism spectrum disorders (ASD) are reviewed based on clinical and research experience, highlighting some older drugs with emerging evidence. Several medications show efficacy in ASD, though controlled studies in ASD are largely lacking. Only risperidone and aripiprazole have Federal Drug Administration approval in the United States. Methylphenidate (MPH) studies showed lower efficacy and tolerability for attention deficit hyperactivity disorder (ADHD) than in the typically developing (TD) population; atomoxetine demonstrated lower efficacy but comparable tolerability to TD outcomes...
June 19, 2023: World Journal of Psychiatry
https://read.qxmd.com/read/37332889/loxapine-in-the-treatment-of-manic-and-psychotic-symptoms-in-an-individual-intolerant-to-multiple-mood-stabilizing-and-antipsychotic-medications
#13
David S Im, Marina Capitanov, Amy M VandenBerg
First-line treatments for schizophrenia and schizoaffective disorder include antipsychotics and mood stabilizers, but their use may at times be limited due to severe adverse events. This case describes a 41-year-old male with a history of schizoaffective disorder and polysubstance use who was admitted to an inpatient psychiatry unit for acute manic and psychotic symptoms in the setting of absconding from his residential home and noncompliance with prescribed psychiatric medications. During his inpatient psychiatric hospitalization, he experienced DRESS (drug reaction with eosinophilia and systemic symptoms) with valproate, nephrogenic diabetes insipidus with lithium, potential neuroleptic malignant syndrome with risperidone, and orthostasis/tachycardia with clozapine...
2023: Case Reports in Psychiatry
https://read.qxmd.com/read/37062836/kcnt2-related-disorders-phenotypes-functional-and-pharmacological-properties
#14
JOURNAL ARTICLE
Maria Cristina Cioclu, Ilaria Mosca, Paolo Ambrosino, Deborah Puzo, Allan Bayat, Saskia B Wortmann, Johannes Koch, Vincent Strehlow, Kentaro Shirai, Naomichi Matsumoto, Stephan J Sanders, Vincent Michaud, Marine Legendre, Antonella Riva, Pasquale Striano, Hiltrud Muhle, Manuela Pendziwiat, Gaetan Lesca, Giuseppe Donato Mangano, Rosaria Nardello, Johannes R Lemke, Rikke S Møller, Maria Virginia Soldovieri, Guido Rubboli, Maurizio Taglialatela
OBJECTIVE: Pathogenic variants in KCNT2 are rare causes of developmental epileptic encephalopathy (DEE). We herein describe the phenotypic and genetic features of patients with KCNT2-related DEE, and the in vitro functional and pharmacological properties of KCNT2 channels carrying 14 novel or previously untested variants. METHODS: Twenty-five patients harboring KCNT2 variants were investigated: 12 were identified through an international collaborative network, 13 were retrieved from the literature...
August 2023: Annals of Neurology
https://read.qxmd.com/read/36542347/dexmedetomidine-sublingual-film-igalmi-for-acute-agitation
#15
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
December 26, 2022: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/36439974/discovery-of-antipsychotic-loxapine-derivatives-against-intracellular-multidrug-resistant-bacteria
#16
JOURNAL ARTICLE
Hsueh-Chun Lin, Yi-Lun Wu, Cheng-Yun Hsu, Man-Yi Lin, Ling-Han Chen, Chung-Wai Shiau, Hao-Chieh Chiu
The emergence and spread of multidrug-resistant bacteria highlight the need for new antibacterial interventions. A screening of 24 newly synthesized dibenzoxazepines identified a small molecule compound, SW14, with potent inhibitory activity against intracellular multidrug-resistant and fluoroquinolone-resistant strains of S. typhimurium in macrophages and epithelial cells. Moreover, intra-macrophagic Salmonella typhi , Yersinia enterocolitica , and Listeria monocytogenes and methicillin-resistant Staphylococcus aureus are also susceptible to SW14...
November 16, 2022: RSC medicinal chemistry
https://read.qxmd.com/read/36231571/actionable-predictive-factors-of-homelessness-in-a-psychiatric-population-results-from-the-rehabase-cohort-using-a-machine-learning-approach
#17
JOURNAL ARTICLE
Guillaume Lio, Malek Ghazzai, Frédéric Haesebaert, Julien Dubreucq, Hélène Verdoux, Clélia Quiles, Nemat Jaafari, Isabelle Chéreau-Boudet, Emilie Legros-Lafarge, Nathalie Guillard-Bouhet, Catherine Massoubre, Benjamin Gouache, Julien Plasse, Guillaume Barbalat, Nicolas Franck, Caroline Demily
BACKGROUND: There is a lack of knowledge regarding the actionable key predictive factors of homelessness in psychiatric populations. Therefore, we used a machine learning model to explore the REHABase database (for rehabilitation database- n = 3416), which is a cohort of users referred to French psychosocial rehabilitation centers in France. METHODS: First, we analyzed whether the different risk factors previously associated with homelessness in mental health were also significant risk factors in the REHABase...
September 27, 2022: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/36180017/antipsychotic-safety-in-liver-disease-a-narrative-review-and-practical-guide-for-the-clinician
#18
REVIEW
Matthew Gunther, Julie A Dopheide
BACKGROUND: Clinicians treating psychiatric disorders in medically ill patients need a comprehensive resource for comparing the risk and types of liver injury associated with antipsychotic therapy. OBJECTIVE: We conducted a narrative review aimed at developing a comprehensive resource comparing antipsychotics with regard to risk of inducing or worsening liver injuries, types of liver injury, associated pharmacokinetic changes, dosing, monitoring, and patient counseling recommendations...
2023: Journal of the Academy of Consultation—Liaison Psychiatry
https://read.qxmd.com/read/36002244/visual-compatibility-and-particle-counter-evaluations-of-syringes-of-intramuscular-psychotropic-coadministered-solutions
#19
JOURNAL ARTICLE
Lydia Djerroud, Gregoire Leclair, Thomas Sullivan, Vincent Dagenais-Beaulé
BACKGROUND: Patients in the acute phase of agitation can require the administration of multiple drugs by intramuscular injection in order to temporarily stabilise their condition. Administration of multiple psychotropic medications in a single syringe can be beneficial to both the patient and healthcare professionals. However, there are very little data in the literature regarding psychotropic drug compatibility in syringes for acute agitation. OBJECTIVE: The aim of this study was to assess the visual compatibility of various combinations of 12 intramuscular psychotropic medications in syringes, and to validate compatibility with the use of a particle counter...
August 24, 2022: European Journal of Hospital Pharmacy. Science and Practice
https://read.qxmd.com/read/35913401/fifty-years-of-experience-with-loxapine-for-the-rapid-non-coercive-tranquilization-of-acute-behavioral-disturbances-in-schizophrenia-patients-and-beyond
#20
JOURNAL ARTICLE
Philippe Nuss, Emmanuelle Corruble, Emmanuelle Baloche, Ricardo P Garay, Pierre-Michel Llorca
INTRODUCTION: Acute behavioral disturbances in psychosis, including agitation, comprise a heterogeneous group of manifestations varying in intensity and duration they last for. They require rapid, non-coercive treatments ranging from verbal de-escalation to the calming effect of pharmacological agents. The treatment goals are reduction of patient suffering and prevention of disease deterioration. Stabilizing rather than sedating is preferred to ensure improved compliance and a stronger therapeutic alliance...
August 10, 2022: Expert Review of Neurotherapeutics
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